{"id":74,"date":"2012-04-17T21:52:56","date_gmt":"2012-04-17T12:52:56","guid":{"rendered":"\/sawamura\/wp\/?p=74"},"modified":"2025-01-28T12:14:51","modified_gmt":"2025-01-28T03:14:51","slug":"astrocytictumor","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/astrocytictumor\/","title":{"rendered":"\u661f\u7d30\u80de\u7cfb\u816b\u760d astrocytic tumor"},"content":{"rendered":"<div class=\"setumei\">\n<p>\u4e8c\u3064\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u3066\uff0c\u3053\u308c\u3092\u7528\u3044\u3066\u6cbb\u7642\u65b9\u6cd5\u304c\u6c7a\u307e\u308a\u307e\u3059,<br \/>\n\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u8a73\u3057\u3044\u8aac\u660e\u306b\u98db\u3073\u307e\u3059\uff0c\u305d\u3061\u3089\u3092\u8aad\u3093\u3060\u65b9\u304c\u3044\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/p>\n<h5><span style=\"color: #000080;\"><strong><a title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\"><span style=\"color: #000080;\">\u661f\u7d30\u80de\u816b <\/span><\/a><\/strong><\/span><span style=\"color: #000080;\"><strong><a title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\"><span style=\"color: #000080;\">IDH\u5909\u7570\u578b astrocytoma IDH mutant\u3000\u30b0\u30ec\u30fc\u30c92,3,4<\/span><\/a><\/strong><\/span><\/h5>\n<h5><a href=\"\/sawamura\/glioma\/glioblastom\/\"><span style=\"color: #000080;\"><strong><span style=\"color: #000080;\">\u81a0\u82bd\u816b IDH\u91ce\u751f\u578b glioblas<\/span><span style=\"color: #000080;\">toma\u00a0GBM<\/span><span style=\"color: #000080;\">\u3000\u30b0\u30ec\u30fc\u30c94<\/span><\/strong><\/span><\/a><\/h5>\n<\/div>\n<h4>\u661f\u306e\u7d30\u80de\uff1f<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-11849 size-large\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes-550x551.jpg\" alt=\"\" width=\"550\" height=\"551\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes-550x551.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytes.jpg 709w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/p>\n<p>\u661f\u7d30\u80de\u816b\u3092GFAP\u67d3\u8272\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u661f\u7d30\u80de\u306f\u8133\u306e\u795e\u7d4c\u7d30\u80de\u3092\u652f\u3048\u308b\u5f79\u5272\u3092\u3057\u307e\u3059\u3002\u5468\u56f2\u306b\u7a81\u8d77\u3092\u4f38\u3070\u3057\u305f\u816b\u760d\u7d30\u80de\uff08\u6fc3\u3044\u8336\u8272\uff09\u304c\uff0c\u5149\u306e\u3092\u653e\u3064\u30ad\u30e9\u30ad\u30e9\u661f\u306e\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u5927\u307e\u304b\u306a\u3053\u3068<\/h4>\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306f\uff0c\u795e\u7d4c\u81a0\u816b\uff08\u30b0\u30ea\u30aa\u30fc\u30de\uff09<\/strong><\/span>\u3092\u4ee3\u8868\u3059\u308b\u816b\u760d\u3067<span style=\"color: #333333;\">\u8133\u816b\u760d\u306e\u7d0420\uff05<\/span>\u3067\u3059<\/li>\n<li>\u826f\u6027\u3068\u8a00\u3048\u308b\u3082\u306e\u306f\u307b\u3068\u3093\u3069\u306a\u304f\uff0c<strong><span style=\"color: #ff0000;\">\u307b\u307c\u5168\u3066\u304c\u60aa\u6027\u816b\u760d<\/span><\/strong>\u3067\u3059<\/li>\n<li>\u8133\u306e\u4e3b\u8981\u306a\u69cb\u6210\u7d30\u80de\u3067\u3042\u308b\u661f\u7d30\u80de \u30a2\u30b9\u30c8\u30ed\u30b0\u30ea\u30a2\u304b\u3089\u767a\u751f\u3057\u307e\u3059<\/li>\n<li>\u5c0f\u5150\u306b\u306f\u60aa\u6027\u5ea6\u306e\u4f4e\u3044\u3082\u306e\uff0c\u9ad8\u9f62\u8005\u306b\u306f\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u3082\u306e\u304c\u591a\u3044\u3067\u3059<\/li>\n<li><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">\u81a0\u82bd\u816b \u30b0\u30ec\u30fc\u30c94<\/a> \u306f\u6700\u3082\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u816b\u760d<\/span><\/strong>\u3067\uff0c\u3068\u304f\u306b\u9ad8\u9f62\u8005\u306e\u5927\u8133\u534a\u7403\u306b\u3067\u304d\u307e\u3059<\/li>\n<li>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306f\uff0c\u60aa\u6027\u5ea6\u3067\u3082\u816b\u760d\u767a\u751f\u5b66\u7684\u306b\u3082\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b\u3068\u306e\u4e2d\u9593\u306b\u4f4d\u7f6e\u3057\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3067\u306f\uff0c10\u5e74\u9593\u89b3\u5bdf\u3057\u3066\u3082\u307b\u3068\u3093\u3069\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u826f\u6027\u306e\u7d4c\u904e\u3092\u305f\u3069\u308b\u3082\u306e\u304c\u7a00\u306b\u3042\u308a\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c9\u306e\u9ad8\u3044\u816b\u760d\u306f\u9032\u884c\u304c\u3068\u3066\u3082\u65e9\u3044\u306e\u3067\u3069\u3093\u3069\u3093\u75c7\u72b6\u304c\u60aa\u304f\u306a\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u3055\u307e\u3056\u307e\u306a\u5897\u5927\u901f\u5ea6\u3092\u793a\u3059<\/span><\/strong>\u306e\u3067\u305d\u308c\u3092\u4e88\u60f3\u3059\u308b\u3053\u3068\u306f\u5bb9\u6613\u306a\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u624b\u8853\u5f8c\uff13\u5e74\u306e\u6642\u70b9\u3067\u306e\u751f\u5b58\u5272\u5408\u306f\uff0c\u9000\u5f62\u6210\u6027\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c9\uff13\u306e\u60a3\u8005\u3055\u3093\u306760%\u7a0b\u5ea6\u3001\u81a0\u82bd\u816b \u30b0\u30ec\u30fc\u30c9\uff14\u3067\u306f20%\u7a0b\u5ea6\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff0c10\u5e74\u751f\u5b58\u5272\u5408\u306f\u3082\u3063\u3068\u4f4e\u304f\u306a\u308a\u307e\u3059<\/li>\n<li>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u00a0\u30b0\u30ec\u30fc\u30c92\u3068\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c93\u306f\u5b8c\u5168\u306b\u6cbb\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u75c5\u7406\u7d44\u7e54\u3092\u898b\u3066\u3082\u30b0\u30ec\u30fc\u30c9\uff12\u3068\uff13\u3001\uff13\u3068\uff14\u306e\u533a\u5225\u306f\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u304b\u3089\uff0c\u305d\u306e\u6642\u306f\uff0c\u30b0\u30ec\u30fc\u30c9\uff12\u304b\uff13\u304f\u3089\u3044\u3068\u8868\u73fe\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u8133\u306e\u3069\u3053\u304b\u3089\u3067\u3082\u767a\u751f\u3057\u3066\u3069\u306e\u5e74\u9f62\u306b\u3082\u307f\u3089\u308c\u307e\u3059\u304c\u3001<span style=\"color: #333333;\">\u6210\u4eba\u3067\u306f\u5927\u8133\u534a\u7403\u306b\u591a\u304f\u3066\u5e7c\u5c0f\u5150\u3067\u306f\u8133\u5e79\u90e8\u306b\u51fa\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/span><\/li>\n<li>\u5f37\u3044\u6d78\u6f64\u6027\u683c\u3092\u793a\u3057\u3066\uff0c<strong><span style=\"color: #ff0000;\">\u5468\u56f2\u306e\u8133\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u767a\u80b2\u3057\u307e\u3059<\/span><\/strong>\u304b\u3089\u3084\u3063\u304b\u3044\u306a\u3082\u306e\u3067\u3059<\/li>\n<li>\u7247\u65b9\u306e\u5927\u8133\u534a\u7403\u306b\u3068\u3069\u307e\u3089\u305a\uff0c\u53cd\u5bfe\u5074\u306e\u534a\u7403\u3084\u8133\u5e79\u90e8\u306b\u307e\u3067\u3057\u307f\u8fbc\u3080\u69d8\u306b\u5e83\u7bc4\u306b\u5e83\u304c\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3059<\/li>\n<li>\u8133\u5ba4\u306e\u58c1\u306b\u6cbf\u3063\u3066\u6d78\u6f64\u3057\u305f\u308a\uff0c\u304f\u3082\u819c\u4e0b\u8154\u3078\u64ad\u7a2e\u8ee2\u79fb\uff08\u3070\u3089\u307e\u304b\u308c\u308b\u3088\u3046\u306b\u5e83\u304c\u308b\uff09\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306f\uff0c\u958b\u982d\u624b\u8853\u3067\u53d6\u308a\u304d\u308c\u305a\uff0c\u624b\u8853\u3060\u3051\u3067\u306f\u6cbb\u3089\u306a\u3044\u3053\u3068\u304c\u307b\u3068\u3093\u3069\u3067\u3059<\/li>\n<li>\u60aa\u3044\u3053\u3068\u3070\u304b\u308a\u3067\u306f\u306a\u304f\u3066\uff0c\u6d78\u6f64\u3057\u3066\u5e83\u304c\u308b\u6027\u8cea\u3092\u3042\u307e\u308a\u6301\u305f\u306a\u3044<span style=\"color: #000080;\"><strong>\u9650\u5c40\u6027\u306e\u661f\u7d30\u80de\u816b<\/strong><\/span>\u304c\u3042\u308a\uff0c\u3053\u306e\u30bf\u30a4\u30d7\u306f\u624b\u8853\u3067\u304d\u3061\u3093\u3068\u53d6\u308c\u3066\uff0c\u6cbb\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u5b09\u3057\u3044\u3082\u306e\u3067\u3059<\/li>\n<li>\u3060\u304b\u3089\uff0c\u767a\u898b\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u5c0f\u3055\u306a\u661f\u7d30\u80de\u816b\u306f\u624b\u8853\u3067\u5168\u6458\u51fa\u3092\u3081\u3056\u3057\u307e\u3057\u3087\u3046<\/li>\n<li>\u4e00\u822c\u7684\u306a\u764c\u3068\u306e\u5927\u304d\u306a\u9055\u3044\u306f\uff0c<span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u7cfb\u816b\u760d\u304c\u8133\u304b\u3089\u4ed6\u306e\u81d3\u5668\u3078\u8ee2\u79fb\u3057\u306a\u3044<\/strong><\/span>\u3053\u3068\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilo\/\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff08\u30b0\u30ec\u30fc\u30c9\uff11\uff09<\/a><\/strong><\/span>\u306f\u5168\u304f\u9055\u3046\u3082\u306e\u3067\u3059\u304b\u3089\u3001\u3053\u306e\u4ef2\u9593\u306b\u5165\u308a\u307e\u305b\u3093<\/li>\n<li>\u307e\u305f\uff0c\u9727\u304c\u304b\u304b\u3063\u305f\u3088\u3046\u306b\u8133\u5168\u4f53\u306b\u5e83\u304c\u308b\u3088\u3046\u306a\u5e83\u7bc4\u56f2\u306a\u3082\u306e\u3092<span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u3000\u795e\u7d4c\u81a0\u816b\u75c7\" href=\"\/sawamura\/braintumors\/glioma\/gliomatosi\/\">\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9 \uff08\u30b0\u30ec\u30fc\u30c94\uff09<\/a><\/strong><\/span>\u3068\u3044\u3044\u3053\u308c\u30822022\u5e74\u6642\u70b9\u3067\u306f\u4ef2\u9593\u306b\u5165\u308a\u307e\u305b\u3093<\/li>\n<\/ul>\n<hr \/>\n<h3><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/contact-natsume\/\">\u590f\u76ee\u6566\u81f3\u304c\u76f8\u8ac7\u306b\u306e\u308a\u307e\u3059\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/h3>\n<p>\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u3064\u3044\u3066\u30e1\u30fc\u30eb\u3067\u76f8\u8ac7\u3067\u304d\u307e\u3059\u3002<strong><a style=\"color: #000080;\" href=\"\/sawamura\/contact-natsume\/\">\u76f8\u8ac7\u30d5\u30a9\u30fc\u30e0\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u958b\u3044\u3066\u304f\u3060\u3055\u3044\u3002<\/a><\/strong><\/p>\n<h4>\u75c7\u72b6<\/h4>\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u5c40\u6240\u75c7\u72b6<\/strong><\/span>\uff1a\u816b\u760d\u306b\u3088\u3063\u3066\u8133\u306e\u4e00\u90e8\u304c\u58ca\u3055\u308c\u305f\u308a\u8133\u304c\u5727\u8feb\u3055\u308c\u305f\u308a\u3057\u3066\u3067\u308b\u904b\u52d5\u9ebb\u75fa\uff08\u8131\u529b\uff09\u3001\u611f\u899a\u969c\u5bb3\uff08\u3057\u3073\u308c\uff09\uff0c\u5931\u8a9e\u75c7\uff08\u3046\u307e\u304f\u8a71\u305b\u306a\u3044\uff09\uff0c\u8996\u91ce\u969c\u5bb3\uff08\u307f\u305a\u3089\u3044\uff09\u3001\u77e5\u80fd\uff08\u304a\u304b\u3057\u306a\u3053\u3068\u3092\u8a00\u3046\uff0c\u8a00\u8449\u6570\u304c\u5c11\u306a\u3044\uff09\u3084\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b\uff08\u7269\u5fd8\u308c\uff09\uff0c\u6027\u683c\u5909\u5316\u306a\u3069\u3055\u307e\u3056\u307e\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/epilepsy\/\">\u75c7\u5019\u6027\u3066\u3093\u304b\u3093<\/a><\/strong><\/span>\uff1a\u3051\u3044\u308c\u3093\u767a\u4f5c\u3082\u591a\u3044\u3067\u3059\uff0c\u4f53\u306e\u4e00\u90e8\u304c\u30b1\u30a4\u30ec\u30f3\u3057\u305f\u308a\u3057\u3073\u308c\u305f\u308a\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u982d\u84cb\u5185\u5727\u4ea2\u9032\u75c7\u72b6<\/strong><\/span>\uff1a\u5927\u304d\u306a\u816b\u760d\u304c\u51fa\u3059\u75c7\u72b6\u3067\u3001\u982d\u75db\u3001\u5410\u304d\u6c17\u3001\u5614\u5410\uff0c\u610f\u8b58\u969c\u5bb3\u306a\u3069\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6c34\u982d\u75c7<\/strong><\/span>\u3068<span style=\"color: #000080;\"><strong>\u816b\u760d\u5185\u51fa\u8840<\/strong><\/span>\u306b\u3088\u308b\u6025\u306a\u610f\u8b58\u969c\u5bb3\u3084\u75c7\u72b6\u306e\u60aa\u5316\u3082\u3042\u308a\u5f97\u307e\u3059<\/li>\n<\/ul>\n<h4>\u8a3a\u65ad<\/h4>\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u8a3a\u65ad\u306fMRI<\/strong><\/span>\u3092\u4f7f\u3044\u307e\u3059<\/li>\n<li>\u30ab\u30c6\u30fc\u30c6\u30eb\u3092\u7528\u3044\u308b\u8133\u8840\u7ba1\u64ae\u5f71DSA\u306f\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093\u3057\uff0c\u5408\u4f75\u75c7\u3082\u3042\u308b\u691c\u67fb\u306a\u306e\u3067\u305f\u3068\u3048\u624b\u8853\u3092\u524d\u63d0\u3068\u3057\u3066\u3082\u884c\u308f\u306a\u3044\u3053\u3068\u306e\u65b9\u304c\u591a\u3044\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u304c\u3068\u3066\u3082\u96e3\u3057\u3044<\/strong><\/span>\u816b\u760d\u3067\u3059\u304b\u3089\uff0c\u8133\u816b\u760d\u306e\u8a3a\u65ad\u306b\u8a73\u3057\u3044\u75c5\u7406\u533b\uff08\u3042\u308b\u3044\u306f\u8133\u5916\u79d1\u533b\uff09\u306e\u5354\u529b\u3082\u6b20\u304b\u305b\u307e\u305b\u3093<\/li>\n<li><span style=\"color: #000080;\"><strong>IDH\u907a\u4f1d\u5b50\u5909\u7570\u3067\u4e88\u5f8c\uff08\u6cbb\u308b\u304b\u3069\u3046\u304b\uff09\u304c\u304b\u306a\u308a\u9055\u3044\u307e\u3059<\/strong><\/span>\u304b\u3089\uff0c\u305d\u308c\u306f\u5fc5\u305a\u898b\u307e\u3059<\/li>\n<li>2025\u5e74\u6642\u70b9\u3067\uff0cIDH\u304c\u91ce\u751f\u578b\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306f\uff0c\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c94\u3068\u3057\u3066\u6cbb\u7642\u3092\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\uff08\u304b\u306a\u308a\u7570\u8ad6\u306f\u3042\u308a\u307e\u3059\uff09<\/li>\n<\/ul>\n<h4>\u624b\u8853\u306f\uff13\u3068\u304a\u308a\u306e\u8003\u3048\u65b9\u304b\u3089\u3057\u3063\u304b\u308a\u9078\u3076<\/h4>\n<h5><span style=\"color: #000080;\"><strong>1. \u751f\u691c\u8853<\/strong><\/span> biopsy<\/h5>\n<p><span style=\"color: #333333;\">\u816b\u760d\u3092\u307b\u3093\u306e\u3061\u3087\u3063\u3068\u63a1\u53d6\u3057\u3066\u75c5\u7406\u78ba\u5b9a\u8a3a\u65ad\u3059\u308b\u3053\u3068\u3067\u3059\uff0c\u3067\u3082\u5b9a\u4f4d\u8133\u624b\u8853\u3042\u308b\u3044\u306f\u5185\u8996\u93e1\u624b\u8853\u3067\u3068\u308c\u305f\u816b\u760d\u304c\u5c0f\u3055\u3059\u304e\u308b\u3068\uff0c\u75c5\u7406\u8a3a\u65ad\u3092\u9593\u9055\u3046\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3042\u308a\u307e\u3059\uff0c\u5b89\u5168\u306b\u884c\u3048\u308b\u306e\u3067\u3042\u308c\u3070\uff0c\u751f\u691c\u8853\u3068\u3044\u3048\u3069\u3082\u5c0f\u3055\u306a\u958b\u982d\u624b\u8853\u306b\u3057\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3057\u3087\u3046\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad\u3082\u5fc5\u8981\u306a\u6642\u4ee3\u306b\u306a\u308a\u307e\u3057\u305f<\/span><\/p>\n<h5><span style=\"color: #000080;\"><strong>2. \u53ef\u53ca\u7684\u5207\u9664<span style=\"color: #000080;\">\u8853 <\/span><\/strong><span style=\"color: #333333;\"><span style=\"color: #000080;\">maximal-safe resection<\/span><br \/>\n<\/span><\/span>\u00a0 \u00a0 \u6e1b\u8377\u624b\u8853 bulk-reduction surgery<\/h5>\n<p>\u5927\u304d\u306a\u816b\u760d\u3092\u958b\u982d\u624b\u8853\u3067\u75c7\u72b6\u304c\u51fa\u306a\u3044\u7a0b\u5ea6\u306b\u3067\u304d\u308b\u3060\u3051\u7121\u7406\u3057\u306a\u3044\u7a0b\u5ea6\u306b\u5207\u9664\u3059\u308b\uff0cmaximal safe resection\u3068\u3044\u3044\u307e\u3059\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b\u306f\u307b\u3068\u3093\u3069\u3053\u306e\u624b\u8853\u306b\u306a\u308a\u307e\u3059<\/p>\n<h5><strong>3. \u7a4d\u6975\u7684\u6458\u51fa\u8853<\/strong> radical resection surgery<\/h5>\n<p>\u5b8c\u5168\u6458\u51fa complete resection \u3042\u308b\u3044\u306f\u8089\u773c\u7684\u306a\u5168\u6458\u51fa gross total removal \u3067\uff0c\u624b\u8853\u3060\u3051\u306e\u6cbb\u7652\u3092\u3081\u3056\u3057\u307e\u3059\uff0c\u3067\u3082\u73fe\u5b9f\u7684\u306b\u306f\u53d6\u308a\u5207\u308c\u308b\u30b1\u30fc\u30b9\u306f\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b IDH-mutant\u306e\u4e00\u90e8\u3067\u9650\u5c40\u6027\u306e\u3082\u306e\u3060\u3051\u3067\u3059<\/p>\n<h4>\u75c5\u7406\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u9078\u629e\u306b\u7528\u3044\u308b\u30b0\u30ec\u30fc\u30c9\u3068\u306f<\/h4>\n<p><span style=\"color: #ff0000;\"><strong>\u57fa\u672c\u7684\u306a\u30b0\u30ec\u30fc\u30c9\u306f\u5149\u9855\u6240\u898b\u3067\u306e\u7d44\u7e54\u50cf\u3067\u6c7a\u3081\u307e\u3059<\/strong><\/span><\/p>\n<h4>2022\u5e74\u6642\u70b9\u3067\u306e\u661f\u7d30\u80de\u816b\u306e\u5206\u985e\u306f\u30b0\u30ec\u30fc\u30c94\u304c\u52a0\u3048\u3089\u308c\u307e\u3059<\/h4>\n<p><span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u304b3<\/strong><\/span><br \/>\nIDH mutant, nuclear ATRX lost, CDKN2A\/B retained<br \/>\n<span style=\"color: #000080;\"><strong>\u3000(\u53e4\u3044\u5206\u985e\u3067\u306f\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92<\/strong><\/span>\u3068<strong><span style=\"color: #000080;\">\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93<\/span><\/strong><span style=\"color: #000080;\">\u3067\u3059)<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c94 \u00a0IDH\u5909\u7570\u578b (\u30b0\u30ec\u30fc\u30c9 4)<\/strong><\/span><br \/>\nIDH mutant, nuclear ATRX lost, <span style=\"color: #000080;\"><strong><em>CDKN2A\/B<\/em> homozygously deleted<br \/>\n<\/strong><span style=\"color: #333333;\">\u7d44\u7e54\u5b66\u7684\u306b\u306f\u30b0\u30ec\u30fc\u30c92\u306b\u76f8\u5f53\u3059\u308b\u6240\u898b\u304c\u3042\u308a\u307e\u3059<\/span><\/span><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/idh-mutant-astrocytoma-h3-3-g34-mutant-diffuse-hemispheric-glioma\/\"><strong style=\"color: #000080;\">H3.3 G34-mutant diffuse hemispheric glioma (\u30b0\u30ec\u30fc\u30c9 4)<\/strong><\/a><\/p>\n<p><a title=\"\u81a0\u82bd\u816b\uff08\u3053\u3046\u304c\u3057\u3085\uff09\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/glioblastom\/\"><span style=\"color: #000080;\"><strong>\u81a0\u82bd\u816b \u30b0\u30ec\u30fc\u30c9\uff14<\/strong><\/span><\/a><br \/>\nIDH wild type, nuclear ATRX retained, typical histology<br \/>\nIDH wild type, including histologically lower grade with\u00a0<em>TERT<\/em> promotor mutation or <em>EGFR<\/em> amplification or +7\/-10 copy number changes<\/p>\n<p><span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u534a\u7403\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><strong> \u30b0\u30ec\u30fc\u30c94<\/strong><\/span> H3.3 G34\u5909\u7570\u578b<br \/>\nIDH wild type, nuclear ATRX lost, H3.3 G34 mutant, age&lt;50<\/p>\n<h4>IDH mutant \u7d44\u7e54\u5b66\u7684\u306b\u30b0\u30ec\u30fc\u30c9\u304c\u4f4e\u304f\u3066\u3082\uff0c\u30b0\u30ec\u30fc\u30c9\uff14\u306e\u3088\u3046\u306a\u3082\u306e<\/h4>\n<p><span style=\"color: #000080;\">IDH mutant, amplification events involving <i>CDK4<\/i> and <i>MYC<\/i>, along with mutations in <i>PIK3R1<\/i><\/span><\/p>\n<h4>IDH-wild type\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306f\uff1f<\/h4>\n<ul>\n<li><span style=\"color: #333333;\">\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067<em>IDH<\/em> wild-type (IDH\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u306a\u3044\u91ce\u751f\u578b\uff09\u3068\u8a3a\u65ad\u3055\u308c\u305fdiffuse astrocytoma\u3067\u306f\uff0c\u7d44\u7e54\u8a3a\u65ad\u3067\u30b0\u30ec\u30fc\u30c92\u3067\u3042\u3063\u3066\u3082\u300c\u539f\u5247\u7684\u306b\u306f\u300d\u30b0\u30ec\u30fc\u30c94 \u81a0\u82bd\u816b\u3068\u3057\u3066\u6cbb\u7642\u3092\u3057\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u3057\u304b\u3057\uff0cMRI\u3067\u614e\u91cd\u306b\u7d4c\u904e\u3092\u898b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/span><\/li>\n<li>\u7279\u306b\uff0c\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u306f\u306a\u304f\uff0c\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067R132\u3092\u307f\u305f\u3060\u3051\u3067\u306f\uff0c2\u5272\u7a0b\u5ea6\u306eIDH1\u5909\u7570\u304c\u898b\u843d\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #333333;\"><span style=\"color: #000080;\"><strong>IDH wild-type diffuse astrocytoma\u3067\u3082\u4e88\u5f8c\u304c\u3068\u3066\u3082\u826f\u3044\u3082\u306e\u3082\u3042\u308a<\/strong><\/span>\u533a\u5225\u3067\u304d\u306a\u3044\u304b\u3089WHO\u306f\uff0ca broad range of clinical courses\u3068\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002\u81e8\u5e8a\u7d4c\u904e\u304b\u3089\u614e\u91cd\u306b\u5224\u65ad\u3057\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #000080;\"><strong><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliomatosi\/\"><span style=\"color: #000080;\">\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9 gliomatosis (grade 4)<\/span><\/a><\/strong><span style=\"color: #333333;\">\u3068\u3044\u3046\u975e\u5e38\u306b\u5e83\u7bc4\u56f2\u306b\u6d78\u6f64\u3059\u308b\u816b\u760d\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/span><\/span><\/li>\n<li><strong style=\"color: #000080;\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/idh-mutant-astrocytoma-h3-3-g34-mutant-diffuse-hemispheric-glioma\/\"><span style=\"color: #000080;\">IDH-mutant astrocytoma;\u00a0homozygous deletion of <i>CDKN2A\/B<\/i> locus (WHO grade<\/span><\/a>4)<\/strong><span style=\"color: #333333;\">\u306fIDH\u5909\u7570\u578b\u3067\u3059\u304c\uff0c\u81a0\u82bd\u816b\u3068\u540c\u3058\u81e8\u5e8a\u50cf\u3092\u793a\u3057\u307e\u3059<\/span><\/li>\n<li><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/idh-mutant-astrocytoma-h3-3-g34-mutant-diffuse-hemispheric-glioma\/\"><strong style=\"color: #000080;\">H3.3 G34-mutant diffuse hemispheric glioma (WHO grade 4)<\/strong><\/a><span style=\"color: #333333;\">\u306f\u5c0f\u5150\u304b\u3089\u82e5\u3044\u6210\u4eba\u306b\u767a\u751f\u3059\u308b\u5e83\u7bc4\u56f2\u306a\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3067\u30b0\u30ec\u30fc\u30c94\u3067\u3059<\/span><\/li>\n<\/ul>\n<\/div>\n<div class=\"setumei\">\n<h4>\u624b\u8853\u5f8c\u306e\u6cbb\u7642\u306e\u8003\u3048\u65b9<\/h4>\n<ul>\n<li>\u9ad8\u9f62\u8005\u306e\u81a0\u82bd\u816b\u306f\u3042\u307e\u308a\u306b\u3082\u4e88\u5f8c\u304c\u60aa\u3044\u306e\u3067\uff0c\u624b\u8853\u3092\u542b\u3081\u3066\u4e00\u5207\u306e\u6cbb\u7642\u3092\u3057\u306a\u3044\u65b9\u304c\u3044\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff08\u7de9\u548c\u30b1\u30a2\u3092\u9078\u3076\uff09<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u6cbb\u7642\u306f\u30b0\u30ec\u30fc\u30c9\u306b\u3088\u3063\u3066\u9055\u3044\u307e\u3059\u304b\u3089<\/span><\/strong>\u4e0b\u306e\u65b9\u3092\u8aad\u3093\u3067\u4e0b\u3055\u3044<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u30b0\u30ec\u30fc\u30c9\uff13\u3068\uff14\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u6b20\u304b\u305b\u307e\u305b\u3093<\/span><\/strong>\u304b\u3089\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u8a08\u753b\u3092\u307f\u3059\u3048\u3066\u624b\u8853\u8a08\u753b\u3092\u7acb\u3066\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3067\u306f\u30b5\u30a4\u30d0\u30fc\u30ca\u30a4\u30d5\u306a\u3069\u306e\u5ba3\u4f1d\u304c\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u304c\uff0c\u7167\u5c04\u88c5\u7f6e\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u306e\u751f\u5b58\u7387\u306e\u3061\u304c\u3044\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u306e\u3067\uff0c\u60d1\u308f\u3055\u308c\u306a\u3044\u3088\u3046\u306b\u3057\u307e\u3057\u3087\u3046<\/li>\n<li>\u653e\u5c04\u7dda\u306b\u3088\u308b\u8133\u969c\u5bb3\u3092\u907f\u3051\u308b\u305f\u3081\u306b\uff0c\u305d\u308c\u305e\u308c\u306e\u816b\u760d\u304c\u5468\u56f2\u306b\u5e83\u304c\u308b\u7bc4\u56f2\uff08\u6d78\u6f64\u9818\u57df\uff09\u3092\u8e0f\u307e\u3048\u3066\uff0c\u653e\u5c04\u7dda\u3092\u3042\u3066\u308b\u9818\u57df\uff08\u7167\u5c04\u91ce\uff09\u3092\u6c7a\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f<\/li>\n<li>\u816b\u760d\u304c\u6d78\u6f64\u3057\u3066\u3044\u306a\u3044\u3068\u306f\u3063\u304d\u308a\u89e3\u308b\u90e8\u5206\u306e\u8133\u306b\u306f\u4f59\u5206\u306a\u653e\u5c04\u7dda\u3092\u5f53\u3066\u306a\u3044\u3068\u3044\u3046\u8003\u3048\u65b9\u3067\uff0cIMRT\u306a\u3069\u306e\u65b9\u6cd5\u3092\u7528\u3044\u3066\u7acb\u4f53\u7684\u306a\u6cbb\u7642\u8a08\u753b\u3092\u305f\u3066\u308b\u65b9\u6cd5\u3067\u3059\u304c\uff0c\u6b8b\u5ff5\u306a\u304c\u3089\u3069\u3053\u3067\u3082\u3067\u304d\u308b\u65b9\u6cd5\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li><strong><a title=\"\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\" href=\"\/sawamura\/braintumors\/glioma\/temozolo\/\"><span style=\"color: #ff0000;\">\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\uff09\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08<\/span><span style=\"color: #ff0000;\">\u30c6\u30e2<\/span><span style=\"color: #ff0000;\">\u30c0\u30fc\u30eb\uff09<\/span><\/a><\/strong>\u3092\u4f7f\u3044\u307e\u3059<\/li>\n<li><a title=\"\u30a2\u30d0\u30b9\u30c1\u30f3\" href=\"\/sawamura\/braintumors\/glioma\/avastine\/\"><span style=\"color: #ff0000;\"><strong>\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac<\/strong><\/span>\u00a0<span style=\"color: #ff0000;\"><strong>\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff08\u30a2\u30d0\u30b9\u30c1\u30f3\uff09<\/strong><\/span><\/a>\u306f\u30b0\u30ec\u30fc\u30c9\uff13\u3068\uff14\u306e\u816b\u760d\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059<\/li>\n<li>\u6fa4\u6751\u306f\u65e5\u672c\u3067\u306e\u30c6\u30e2\u30c0\u30fc\u30eb\u3068\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u6700\u521d\u306e\u6cbb\u9a13\u306b\u53c2\u52a0\u3057\u307e\u3057\u305fo(^o^)o<\/li>\n<\/ul>\n<hr \/>\n<h3 class=\"style2\"><span style=\"color: #000080;\"><strong style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">\u3073\u307e\u3093\u6027\u661f\u7d30<span style=\"color: #000080;\">\u80de\u816b\uff08\u661f\u7d30\u80de\u816b\u30b0\u30ec<\/span><\/a><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">\u30fc\u30c9\uff12\uff09\u8a73\u3057\u304f\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/span><\/strong><\/span><\/h3>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diffuseastro1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-7027\" title=\"diffuseastro\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diffuseastro1-265x300.jpg\" alt=\"\" width=\"265\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diffuseastro1-265x300.jpg 265w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diffuseastro1-530x600.jpg 530w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diffuseastro1.jpg 851w\" sizes=\"auto, (max-width: 265px) 100vw, 265px\" \/><\/a><br \/>\n\u307c\u30fc\u3063\u3068\u767d\u304f\u307f\u3048\u308b\u306e\u304c\u661f\u7d30\u80de\u816b\u3067\u3059\u3002\u3053\u306e\u816b\u760d\u306f\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u816b\u760d\u3067\u3057\u305f\u3002\u5b9f\u969b\u306b\u306f\u3053\u306eMRI\u3067\u767d\u304f\u306b\u3058\u3093\u3067\u6620\u3063\u3066\u898b\u3048\u308b\u9818\u57df\u3088\u308a\uff0c\u816b\u760d\u306f\u3055\u3089\u306b\u5e83\u3044\u7bc4\u56f2\u306b\u6d78\u6f64\u3057\u3066\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u3059\u3054\u304f\u5927\u304d\u3044\u306e\u3067\u3059\u304c\uff0c\u3053\u308c\u3067\u3082\u7121\u75c7\u72b6\u3067\u3059\u3002\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306f\u8133\u306e\u4e2d\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u767a\u80b2\u3059\u308b\u306e\u3067\u6cbb\u7642\u304c\u96e3\u3057\u3044\u306e\u3067\u3059\u3002\u624b\u8853\u3067\u3053\u308c\u3092\u5168\u90e8\u3068\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<strong><span style=\"color: #000080;\">\u6d78\u6f64\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/span><\/strong> infiltrative glioma\u306e\u5178\u578b\u4f8b\u3067\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytomakh3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-7025\" title=\"astrocytomakh3\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytomakh3-285x300.jpg\" alt=\"\" width=\"285\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytomakh3-285x300.jpg 285w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytomakh3-550x577.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astrocytomakh3.jpg 709w\" sizes=\"auto, (max-width: 285px) 100vw, 285px\" \/><\/a><br \/>\n\u3067\u3082\u9006\u306b\uff0c\u304b\u306a\u308a\u9650\u5c40\u6027\u3067\u6b63\u5e38\u8133\u3068\u306e\u5883\u754c\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u3066\uff0c\u624b\u8853\u3067\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308b\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3082\u3042\u308a\u307e\u3059\u3002\u4e0a\u306e\u4f8b\u3068\u306f\uff0c\u75c5\u7406\u8a3a\u65ad\u304c\u540c\u3058\u3068\u306f\u601d\u3048\u306a\u3044\u304f\u3089\u3044\u3067\u3059\u3002\u3053\u3046\u3044\u3046\u306e\u3092<strong><span style=\"color: #000080;\">\u9650\u5c40\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/span><\/strong> localized glioma\u3068\u3044\u3044\u307e\u3059\u3002<\/p>\n<p><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u4e21\u8005\u3068\u3082\u306b<\/span><strong>IDH1\u5909\u7570\u306e\u3042\u308b\u4f8b<\/strong><\/span>\u3067\u3057\u305f\u3002IDH\u5909\u7570\u578b \u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c9\uff12\u3068\u3044\u3063\u3066\u3082\u304b\u306a\u308a\u81e8\u5e8a\u50cf\u3068\u6cbb\u7642\u6cd5\uff0c\u4e88\u5f8c\u306b\u7570\u306a\u308a\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4><strong>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306e\u5927\u307e\u304b\u306a\u3053\u3068<\/strong><\/h4>\n<ul>\n<li>\u307e\u305a\u6cbb\u7642\u3092\u3059\u308b\u3079\u304d\u304b\u3069\u3046\u304b\u3092\u8003\u3048\u307e\u3059<\/li>\n<li>\u4f55\u5e74\u3082\u7d4c\u904e\u3092\u898b\u3066\u3082\u307b\u3068\u3093\u3069\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059<span style=\"color: #000080;\"><strong><a title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306e\u4f8b\" href=\"\/sawamura\/braintumors\/glioma\/diffuseastrocytoma\/\">\uff08\u5b9f\u4f8b\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/strong><\/span><\/li>\n<li>\u8a3a\u65ad\u3060\u3051\u3092\u306f\u3063\u304d\u308a\u3055\u305b\u305f\u3044\u6642\u306f\uff0c\u751f\u691c\u8853\uff08\u816b\u760d\u3092\u3061\u3087\u3073\u3063\u3068\u63a1\u308b\uff09\u3092\u3057\u307e\u3059<\/li>\n<li>\u9650\u5c40\u6027\u3067\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308b\u3082\u306e\u306f\uff0c\u9811\u5f35\u3063\u3066\u5b8c\u5168\u6458\u51fa\u3057\u307e\u3059\uff0c\u305d\u308c\u3067\u5b8c\u6cbb\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u6b27\u7c73\u306e\u5927\u304d\u306a\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0c\u661f\u7d30\u80de\u816b\uff08\u30b0\u30ec\u30fc\u30c9\uff12\uff09\u306b\u5bfe\u3057\u3066\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u6709\u52b9\u6027\u306f\u306f\u3063\u304d\u308a\u3057\u307e\u305b\u3093\u3067\u3057\u305f<\/li>\n<li>\u73fe\u5728\u3067\u306f\uff0c\u624b\u8853\u5f8c\u306b\u816b\u760d\u304c\u5897\u5927\u3057\u305f\u3068\u304d\uff08\u518d\u71c3\uff09\u306b45-50\u30b0\u30ec\u30a4\u304f\u3089\u3044\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3079\u304d\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u6b8b\u5ff5\u306a\u304c\u3089\uff0c\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\uff09\u3067\u6709\u52b9\u6027\u3092\u8a3c\u660e\u3055\u308c\u305f\u3082\u306e\u306f\u3042\u308a\u307e\u305b\u3093\u3057\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3082\u540c\u69d8\u3067\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\u4e00\u822c\u7684\u306a\u6cbb\u7642\u306f\uff0c\u3082\u3057\u3067\u304d\u308c\u3070\u5168\u90e8\u6458\u51fa\u3059\u308b<\/li>\n<li>\u624b\u8853\u3067\u816b\u760d\u304c\u6b8b\u308c\u3070\u7d4c\u904e\u89b3\u5bdf\u3067\u69d8\u5b50\u3092\u898b\u308b<\/li>\n<li>\u6b8b\u3063\u305f\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u308a\u305d\u3046\u306a\u5834\u5408\u300145-50\u30b0\u30ec\u30a4\u304f\u3089\u3044\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u3057\u304b\u3057\uff0c\u624b\u8853\u3067\u6b8b\u3063\u305f\u816b\u760d\u304c\u660e\u3089\u304b\u306b\u5927\u304d\u304f\u306a\u308b\u306e\u304c\u308f\u304b\u308b\uff08\u5f37\u304f\u4e88\u60f3\u3055\u308c\u308b\uff09\u3068\u304d\u3082\u3042\u308a\u307e\u3059\u306e\u3067\uff0c\u3053\u306e\u6642\u306b\u306f\uff0c\u3057\u304b\u305f\u304c\u306a\u3044\u306e\u3067\u624b\u8853\u5f8c\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u79fb\u308a\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u3068\u3066\u3082\u5e83\u3044\u9818\u57df\u306b\u5fc5\u8981\u3068\u306a\u308b\u5834\u5408\u306b\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306b\u3086\u3063\u304f\u308a\u3067\u3059\u304c\u77e5\u80fd\uff08\u8a8d\u77e5\u6a5f\u80fd\uff09\u306e\u4f4e\u4e0b\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306f\u9577\u671f\u751f\u5b58\u3082\u671f\u5f85\u3067\u304d\u307e\u3059\u304b\u3089\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u308b\u524d\u306b\u526f\u4f5c\u7528\u3092\u3057\u3063\u304b\u308a\u805e\u304d\u307e\u3057\u3087\u3046<\/li>\n<li>\u75c5\u7406\u8a3a\u65ad\u3067<span style=\"color: #000080;\"><strong>IDH1\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u5909\u7570<\/strong><\/span>\u304c\u3042\u308b\u3068\u6cbb\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<h4><strong><a title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306e\u4f8b\" href=\"\/sawamura\/braintumors\/glioma\/diffuseastrocytoma\/\">\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306e\u4f8b\u3092\u3082\u3063\u3068\u898b\u305f\u3044\u4eba\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/strong><\/h4>\n<hr \/>\n<h3 class=\"style2\"><span style=\"color: #000080;\"><a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\">\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff08\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c9\uff13\uff09\u8a73\u3057\u304f\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/span><\/h3>\n<\/div>\n<div class=\"setumei\">\n<hr \/>\n<h3><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">\u81a0\u82bd\u816b\uff08\u30b0\u30ec\u30fc\u30c9\uff14\uff09\u8a73\u3057\u304f\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/span><\/h3>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmt2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-7110 alignnone\" title=\"gbmt2\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmt2-200x200.png\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmflare.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-7111 alignnone\" title=\"gbmflare\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmflare-200x200.png\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmgad.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-7112 alignnone\" title=\"gbmgad\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/gbmgad-200x200.png\" alt=\"\" width=\"200\" height=\"200\" \/><br \/>\n<\/a>\u5de6\u304b\u3089\u3001T2\u5f37\u8abf\u753b\u50cf\uff0cMRI\u306eFLAIR\u30d5\u30ec\u30a2\u50cf\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u50cf\u3067\u3059\u3002<\/p>\n<ul>\n<li>\u30d5\u30ec\u30a2\u3068T2\u3067\u767d\u304f\u307c\u30fc\u3063\u3068\u307f\u3048\u308b\u3068\u3053\u308d\u306f\u816b\u760d\u306e\u3042\u308b\u5834\u6240\u3067\u3059\u3002\u816b\u760d\u5468\u8fba\u306e\u8133\u6d6e\u816b\u3082\u767d\u304f\u6620\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30b0\u30ec\u30fc\u30c9\uff14\u306e\u81a0\u82bd\u816b\u3067\u306f\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3068\u3044\u3046\u9020\u5f71\u5264\u3092\u4f7f\u3046\u3068\u53f3\u5074\u306e\u5199\u771f\u306e\u3088\u3046\u306b\uff0c\u816b\u760d\u306e\u5185\u90e8\u304c\u767d\u304f\u5f37\u304f\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u30b0\u30ec\u30fc\u30c9\uff13\u3067\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5897\u5f37\u3055\u308c\u306a\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u540c\u69d8\u306b\uff0c\u5b9f\u969b\u306b\u306f\u3053\u306eMRI\u3067\u6620\u3063\u3066\u898b\u3048\u308b\u9818\u57df\u3088\u308a\u816b\u760d\u306f\u5e83\u3044\u7bc4\u56f2\u306b\u6d78\u6f64\u3057\u3066\u5e83\u304c\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/li>\n<li><span style=\"color: #333333;\"><span style=\"color: #000080;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\uff08\u5206\u5272\u7167\u5c04\uff09\u304c\u6b20\u304b\u305b\u306a\u3044\u816b\u760d<\/strong><\/span>\u3067\u3059\u304b\u3089\uff0c<span style=\"color: #000080;\"><strong>\u624b\u8853\u5f8c\u306f\uff0c\u75c5\u7406\u8a3a\u65ad\u3092\u624b\u65e9\u304f\u3057\u3066\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u8a08\u753b\u3057\u307e\u3059<\/strong><\/span>\u3002\u3050\u305a\u3050\u305a\u3057\u3066\u3044\u308b\u3068\u624b\u8853\u5f8c\u306b\u307e\u305f\u3059\u3050\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u3082\u65bd\u8a2d\u306b\u3088\u3063\u3066\u6280\u8853\u306e\u5dee\u304c\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u305d\u306e\u70b9\u3082\u3057\u3063\u304b\u308a\u8003\u3048\u307e\u3059\u3002\u307e\u305f\u5f8c\u907a\u75c7\u3092\u5c11\u306a\u304f\u3059\u308b\u305f\u3081\u306b\u306f\u4f59\u5206\u306a\u653e\u5c04\u7dda\u3092\u5f53\u3066\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3082\u5927\u5207\u3067\u3059\u304c\uff0cIMRT\u306a\u3069\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u8a08\u753b\u3092\u3067\u304d\u308b\u3068\u3053\u308d\u306f\u591a\u304f\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/span><\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u30b0\u30ec\u30fc\u30c9\uff13\u3068\uff14\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306b\u306f\uff0c\u624b\u8853\u3067\u3067\u304d\u308b\u9650\u308a\u6458\u51fa\u3057\u305f\u5f8c\u306b\uff0c<\/span><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\u30c6\u30e2\u30c0\u30fc\u30eb\uff09<\/strong><\/span>\u3092\u7528\u3044\u308b\u306e\u304c\u4e16\u754c\u306e\u6a19\u6e96\u6cbb\u7642\u3067\u3059\u3002<\/li>\n<li>\u7279\u306b\uff0c<span style=\"color: #000080;\"><strong>\u624b\u8853\u3067\u6700\u5927\u9650\u306b\u816b\u760d\u3092\u6458\u51fa\u3067\u304d\u305f\u3068\u304d\u306b\u6cbb\u308b\u78ba\u7387\u306f\u9ad8\u304f\u306a\u308a\u307e\u3059\u304c\u3001<\/strong><\/span>\u8133\u3092\u816b\u760d\u3068\u4e00\u7dd2\u306b\u53d6\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u306e\u3067<span style=\"color: #000080;\"><strong>\u3072\u3069\u3044\u5f8c\u907a\u75c7\u3092\u6b8b\u3059\u3088\u3046\u306a\u624b\u8853\u306f\u3057\u307e\u305b\u3093<\/strong><\/span>\u3002\u307e\u305f\u3069\u306e\u3088\u3046\u306a\u624b\u8853\u624b\u6bb5\uff08\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u3084\u899a\u9192\u4e0b\u624b\u8853\u3084\u8853\u4e2dMRI\uff09\u3092\u7528\u3044\u3066\u3082\uff0c\u81a0\u82bd\u816b\u304c\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u7d76\u5bfe\u306b\u3042\u308a\u5f97\u307e\u305b\u3093\u3002<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u306f\uff0c<span style=\"color: #000080;\"><strong>50-60\u30b0\u30ec\u30a4\u304f\u3089\u3044\u306e\u7dda\u91cf\u304c\u5fc5\u8981<\/strong><\/span>\u3067\u3059\u304c\u3001\u816b\u760d\u306e\u5e83\u304c\u308a\u3068\u90e8\u4f4d\u306b\u3088\u3063\u3066\u306f\u816b\u760d\u306e\u5897\u6b96\u306f\u6291\u5236\u3055\u308c\u3066\u3082\u77e5\u80fd\u306e\u4f4e\u4e0b\u306a\u3069\u306e\u653e\u5c04\u7dda\u969c\u5bb3\u304c\u51fa\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u306a\u3044\u3068\u9577\u671f\u751f\u5b58\u306f\u671f\u5f85\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n<li><strong><span style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30c0\u30fc\u30eb\uff09<\/span><\/strong>\u3068\u3044\u3046\u85ac\u5264\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u30c6\u30e2\u30c0\u30fc\u30eb\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b\u98f2\u3093\u3067\uff0c\u5165\u9662\u6cbb\u7642\u304c\u7d42\u3063\u3066\u304b\u3089\u3082\u5916\u6765\u3067\u7d9a\u3051\u3066\u98f2\u3080\u85ac\u3067\u3059\u3002<\/li>\n<li>\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c9\uff13\u3067\u306e\uff15\u5e74\u751f\u5b58\u5272\u5408\u306f40\uff05\u7a0b\u5ea6\u3067\u3059\u3002\u307e\u305f\uff0c\u81a0\u82bd\u816b\u30b0\u30ec\u30fc\u30c9\uff14\u306e\u5834\u5408\u306e\u5e73\u5747\u7684\u306a\u751f\u5b58\u671f\u9593\u306f\uff0c\u6b8b\u5ff5\u306a\u304c\u3089\u624b\u8853\u30fb\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u3057\u3066\u308215-20\u30f6\u6708\u304f\u3089\u3044\u3067\u3059\u3002\u3067\u3082\u5b9f\u969b\u306b5\u5e74\u4ee5\u4e0a\u9577\u671f\u751f\u5b58\u3057\u3066\u304a\u3089\u308c\u308b\u60a3\u8005\u3055\u3093\u3082\u3044\u307e\u3059\u304b\u3089\uff0c\u5e0c\u671b\u3092\u6301\u3063\u3066\u9069\u5207\u306a\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u3087\u3046\u3002<\/li>\n<\/ul>\n<h5>\u3053\u3053\u304b\u3089\u4e0b\u306f\u5c02\u9580\u533b\u5411\u3051<\/h5>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlbaby3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-thumbnail wp-image-10157\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlbaby3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlbaby3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlbaby3-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<h3><span style=\"color: #000080;\">\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u53e4\u3044WHO\u5206\u985e 2016\u5e74\u6642\u70b9<\/span><\/h3>\n<p align=\"left\"><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">Diffuse astrocytoma (grade II), IDH mutant\u3000\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b IDH\u5909\u7570\u3042\u308a<br \/>\n<\/a><\/strong><\/span><a href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\"><strong><span style=\"color: #000080;\">Gemistocytic astrocytoma, IDH mutant<br \/>\n<\/span><\/strong><\/a><i>Diffuse astrocytoma IDH wild-type<\/i><a href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\"><i><br \/>\n<\/i><\/a><a href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\"><span style=\"color: #000080;\"><strong>Diffuse astrocytoma<\/strong><strong>, NOS<\/strong><\/span><\/a><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">\u3000\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b<\/a><\/strong><\/span><\/p>\n<hr \/>\n<blockquote>\n<p align=\"left\"><a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\"><strong><span style=\"color: #000080;\">Anaplastic astrocytoma (grade III), IDH mutant\u3000\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b IDH\u5909\u7570\u3042\u308a<br \/>\n<\/span><\/strong><\/a><i>Anaplastic astrocytoma, IDH wild-type<a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\"><br \/>\n<\/a><\/i><a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\"><span style=\"color: #000080;\"><strong>Anaplastic astrocytoma, NOS<\/strong><\/span><\/a><strong><span style=\"color: #000080;\"><strong><a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\">\u3000<\/a><\/strong><\/span><\/strong><a href=\"\/sawamura\/glioma\/anapestic-astrocytoma\/\"><strong><span style=\"color: #000080;\">\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b<\/span><\/strong><\/a><\/p>\n<hr \/>\n<p align=\"left\"><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u81a0\u82bd\u816b\" href=\"\/sawamura\/braintumors\/glioma\/glioblastom\/\">Glioblastoma (grade IV), IDH wild-type\u3000\u81a0\u82bd\u816b\u00a0<\/a><a style=\"color: #000080;\" title=\"\u81a0\u82bd\u816b\" href=\"\/sawamura\/braintumors\/glioma\/glioblastom\/\">ID<\/a>H\u5909\u7570\u306a\u3057<br \/>\n<\/span><\/strong>\u00a0 \u00a0Giant cell glioblastoma (grade IV)\u3000\u5de8\u7d30\u80de\u6027\u81a0\u82bd\u816b<br \/>\nGliosarcoma (grade IV)\u3000\u81a0\u8089\u816b<br \/>\n<em>Epithelioid glioblastoma (grade IV)<\/em>\u3000\u985e\u4e0a\u76ae\u6027\u81a0\u82bd\u816b<br \/>\n<strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">Glioblastoma, IDH mut<\/a><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">ant\u00a0 \u81a0\u82bd\u816b IDH\u5909\u7570\u3042\u308a<\/a><br \/>\n<\/span><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">Glioblastoma, NOS<\/a><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">\u00a0 \u81a0\u82bd\u816b<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n\u661f\u7d30\u80de\u816b\u760d\u3068\u3044\u3046\u540d\u524d\u306f\u4ed8\u3044\u3066\u3044\u308b\u306e\u3067\u3059\u304c\uff0cpilocytic astrocytoma, pyromyxoid astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma\u306f\uff0c\u907a\u4f1d\u5b66\u7684\u306b\u3082\u81e8\u5e8a\u7684\u306b\u3082\u5168\u304f\u7570\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u81e8\u5e8a\u533b\u306f\u3053\u308c\u3089\u3092astrocytoma, anaplastic astrocytoma, glioblastoma\u3068\u306f\u5225\u500b\u306e\u816b\u760d\u7fa4\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<ul>\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilo\/\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u00a0<\/a><a style=\"color: #000080;\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilo\/\">pil<\/a><a style=\"color: #000080;\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilo\/\">ocytic astrocytoma<\/a><\/strong><\/span>\u00a0(WHO grade 1)<\/li>\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u4e0a\u8863\u4e0b\u5de8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/subepgiantastro\/\">\u4e0a\u8863\u4e0b\u5de8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u00a0<\/a><a style=\"color: #000080;\" title=\"\u4e0a\u8863\u4e0b\u5de8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/subepgiantastro\/\">subependymal giant cell astrocytoma<\/a><\/strong><\/span>\u00a0(WHO grade 1)<\/li>\n<li><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/braintumors\/glioma\/pleomorphicxantho\/\">\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b\u00a0p<\/a><a style=\"color: #000080;\" title=\"\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/braintumors\/glioma\/pleomorphicxantho\/\">leomorphic xanthoastrocyt<\/a><a style=\"color: #000080;\" title=\"\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/braintumors\/glioma\/pleomorphicxantho\/\">oma<\/a><\/span><\/strong>\u00a0(WHO grade 2, 3)<\/li>\n<\/ul>\n<hr \/>\n<h5><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/granularcellastrocytoma\/\">granular cell astrocytoma \u9846\u7c92\u7d30\u80de\u661f\u7d30\u80de\u816b\uff08<\/a>\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/strong><\/span><\/h5>\n<p>\u6975\u3081\u3066\u7a00\u306a\u9ad8\u60aa\u5236\u5ea6\u306e\u661f\u7d30\u80de\u7cfb\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059\uff0c\u5225\u30da\u30fc\u30b8\u306b\u3042\u308a\u307e\u3059<\/p>\n<h5><span style=\"color: #000080;\"><strong>IDH-mutant astrocytoma<br \/>\nhomozygous deletion of <i>CDKN2A\/B<\/i> locus (WHO grade 4)<\/strong><\/span><\/h5>\n<ul>\n<li>2016\u5e74\u5206\u985e\u3067\u306f\uff0cIDH\u5909\u7570\u578b\u306e\u81a0\u82bd\u816b\u3068\u547c\u3070\u308c\u305f\u3082\u306e\u3067\u3059<\/li>\n<li>\u81a0\u82bd\u816b\u3068\u540c\u3058\u6cbb\u7642\u304c\u306a\u3055\u308c\u307e\u3059\u304c\uff0c\u4e88\u5f8c\u306f\u6975\u3081\u3066\u4e0d\u826f\u3067\u3059<\/li>\n<\/ul>\n<ol>\n<li>Shirahata M: Novel, improved grading system(s) for IDH-mutant astrocytic gliomas. Acta Neuropathol\u00a02018<\/li>\n<li>Brat DJ: cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. Acta Neuropathol\u00a02020<\/li>\n<\/ol>\n<hr \/>\n<h4><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/temozolo\/\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u57fa\u672c\u7684\u306a\u8ad6\u6587<\/strong><\/a><\/span><\/h4>\n<\/div>\n<div class=\"setumei\">\n<p>New England Journal of Medicine\u3068\u3044\u3046\u3068\u3066\u3082\u6a29\u5a01\u306e\u9ad8\u3044\u96d1\u8a8c\u306b\u81a0\u82bd\u816b\u3078\u306e\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u52b9\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002Stupp R, et al. : Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005, 352: 987-996, Hegi M, et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005, 352: 997-1003<\/p>\n<p>\u30e8\u30fc\u30ed\u30c3\u30d1\u3068\u30ab\u30ca\u30c0\u3067\u884c\u308f\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3067\u3059\u3002573\u4eba\u306e\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u306f\u653e\u5c04\u7dda\u6cbb\u7642\uff0860\u30b0\u30ec\u30a4\uff09\u306e\u307f\u3068\u653e\u5c04\u7dda\u6cbb\u7642\uff0860\u30b0\u30ec\u30a4\uff09\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3059\u308b\u7fa4\u306b\u632f\u308a\u5206\u3051\u3089\u308c\u3066\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u307e\u305a75mg\/m2\u306e\u91cf\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b\u6bce\u65e5\u98f2\u3080\u3068\u3044\u3046\u65b9\u6cd5\u3067\u6295\u4e0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304b\u3089150-200mg\/m2\uff085\u65e5\u9593\u670d\u7528\uff0c28\u65e5\u5468\u671f\uff09\u30921\u30b3\u30fc\u30b9\u3068\u3057\u30666\u30b3\u30fc\u30b9\u307e\u3067\u8ffd\u52a0\u3057\u307e\u3059\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502428\u30f6\u6708\u306e\u6642\u70b9\u3067\u306e\u5168\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u7fa4\u304c12.1\u30f6\u6708\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3066\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u7fa4\u3067\u306f14.6\u30f6\u6708\u3067\u3057\u305f\u3002\u3061\u3087\u3063\u3068\u5bc2\u3057\u3044\u306e\u3067\u3059\u304c\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3059\u308b\u30682.5\u30f6\u6708\u306e\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u653e\u5c04\u7dda\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u7fa4\u3067\u306e\uff12\u5e74\u751f\u5b58\u5272\u5408\u306f26.5%\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u7fa4\u3067\u306f10.4%\u3067\u3057\u305f\u3002\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f7%\u306e\u60a3\u8005\u3055\u3093\u306b\u30b0\u30ec\u30fc\u30c93-4\u306e\u8840\u6db2\u6bd2\u6027\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u3068\u3066\u3082\u8efd\u3044\u3082\u306e\u3068\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u81a0\u82bd\u816b\u306e\u816b\u760d\u7d30\u80de\u306e\u4e2d\u306bMGMT\u3068\u3044\u3046\u907a\u4f1d\u5b50\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u5316\u5b66\u7642\u6cd5\u306e\u52b9\u679c\u3092\u6d88\u3057\u3066\u3057\u307e\u3046\u50cd\u304d\u3092\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002MGMT\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u90e8\u5206\u306b\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u81a0\u82bd\u816b\u3092\u3082\u3064\u60a3\u8005\u3055\u3093\u306e\u65b9\u304c\u751f\u547d\u4e88\u5f8c\u304c\u3088\u3044\u3053\u3068\u304c\u5224\u308a\u307e\u3057\u305f\u3002\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u81a0\u82bd\u816b\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u3063\u305f\u6cbb\u7642\u3092\u3059\u308b\u3068\uff0c\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f21.7\u30f6\u6708\u3067\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u30e1\u30c1\u30eb\u5316\u304c\u306a\u3044\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u8ffd\u52a0\u3057\u3066\u3082\u306f\u3063\u304d\u308a\u3057\u305f\u52b9\u679c\u304c\u306a\u3044\u3088\u3046\u3067\u3042\u308b\u3068\u3082\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e8b\u5b9f\u306f\uff0c\u30e1\u30c1\u30eb\u5316\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u65b9\u304c\u826f\u3044\u304b\u3069\u3046\u304b\u304c\u3042\u3089\u304b\u3058\u3081\u5224\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\uff12\u3064\u306e\u8ad6\u6587\u306f\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\u3068\uff14\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d\uff08\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b\uff09\u306b\u5bfe\u3057\u3066\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u304c\u4e16\u754c\u7684\u306a\u6a19\u6e96\u7684\u6cbb\u7642\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u3044\u3046\u30a4\u30f3\u30d1\u30af\u30c8\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u6cbb\u7642\u306f\u30b0\u30ec\u30fc\u30c9\uff14\u306b\u6e96\u3058\u308b\u306e\u3067\u305d\u3046\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3082\u3061\u308d\u3093\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u670d\u7528\u3067\u5f97\u3089\u308c\u308b\u52b9\u679c\u306f\u5927\u304d\u306a\u3082\u306e\u3067\u306f\u306a\u304f\u3066\uff0c\u3053\u306e\uff12\u3064\u306e\u816b\u760d\u578b\u306e\u6b7b\u4ea1\u7387\u304c\u3068\u3066\u3082\u9ad8\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3092\u8986\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\uff0c\u3053\u306e30\u5e74\u304f\u3089\u3044\u306e\u9593\u306b\u307b\u3068\u3093\u3069\u4f55\u306e\u9032\u6b69\u3082\u306a\u304b\u3063\u305f\u60aa\u6027\u661f\u7d30\u80de\u816b\u306e\u5316\u5b66\u7642\u6cd5\u306b\u5927\u304d\u306a\u8ee2\u6a5f\u3092\u3082\u305f\u3089\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u306b\u306f\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u304b\u306a\u3044\u304b\u3092\u8abf\u3079\u308b\u65b9\u6cd5\u306f\u96e3\u3057\u3044\u3057\uff0c\u30e1\u30c1\u30eb\u5316\u304c\u306a\u3044\u304b\u3089\u3068\u3044\u3063\u3066\u30c6\u30e2\u30c0\u30fc\u30eb\u306b\u304b\u308f\u308b\u5316\u5b66\u7642\u6cd5\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\uff0c\u3053\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u3088\u308b\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u304c\u3055\u308c\u308b\u306e\u306f\u307e\u3060\u5c06\u6765\u306e\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\"><strong>\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac<\/strong><\/span><\/h4>\n<p><span style=\"color: #333333;\">1995\u5e74\u304f\u3089\u3044\u304b\u3089\uff0c\u60aa\u6027\u795e\u7d4c\u81a0\u816b\uff08\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\uff09\u304c\u6210\u9577\u3059\u308b\u305f\u3081\u306b\u5fc5\u7528\u3068\u3059\u308b\u5206\u5b50\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u53d7\u5bb9\u4f53\uff09\u304c\u305f\u304f\u3055\u3093\u77e5\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u307e\u3067\u306f\u5b9f\u9a13\u5ba4\u306e\u4e2d\u3067\u306e\u304a\u8a71\u3067\u3057\u305f\u304c\uff0c\u4eca\u306f\u305f\u304f\u3055\u3093\u306e\u85ac\uff08\u5316\u5b66\u7642\u6cd5\u5264\u3084\u6297\u4f53\uff09\u304c\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u81e8\u5e8a\u8a66\u9a13\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u307b\u3068\u3093\u3069\u306f\u6b27\u7c73\u3067\u306e\u304a\u8a71\u3067\u3042\u308a\uff0c\u65e5\u672c\u3067\u306f\u6cbb\u9a13\u3082\u59cb\u307e\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"color: #333333;\">\u305f\u3068\u3048\u3070VEGF\u3068\u3044\u3046\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u306e\u50cd\u304d\u3092\u6291\u3048\u308b<\/span><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/avastine\/\"><span style=\"color: #000080;\"><strong>\u30a2\u30d0\u30b9\u30c1\u30f3 (avastin, \u30d9\u30d0\u30b7\u30ba\u30de\u30d6, bevacizumab)<\/strong><\/span><\/a> <span style=\"color: #333333;\">\u3068\u3044\u3046\u6297\u4f53\u3067\u3059\u3002\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306e\u6700\u3082\u5927\u304d\u306a\u554f\u984c\u306f\uff0c<\/span><strong><span style=\"color: #ff0000;\">\u65b0\u305f\u306b\u958b\u767a\u3055\u308c\u308b\u85ac\u5264\u306e\u5024\u6bb5\u304c\u3068\u3093\u3067\u3082\u306a\u304f\u9ad8\u3044<\/span><\/strong>\u3053<span style=\"color: #333333;\">\u3068\u3067\u3059\u3002\u30c6\u30e2\u30c0\u30fc\u30eb\u3067\u3082\u9ad8\u984d\u3067\u4f7f\u3048\u306a\u3044\u60a3\u8005\u3055\u3093\u304c\u3044\u308b\u306e\u306b\uff0c\u3069\u3046\u306a\u308b\u304b\u60f3\u50cf\u304c\u3064\u304b\u306a\u3044\u304f\u3089\u3044\u306e\u533b\u7642\u8cbb\u304c\u304b\u304b\u308b\u6cbb\u7642\u6cd5\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/span><\/p>\n<p><span style=\"color: #333333;\">\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3067\u306f\uff0c\u816b\u760d\u7d30\u80de\u304cEGFR\uff08\u4e0a\u76ae\u7d30\u80de\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff09\u3068\u3044\u3046\u306e\u3092\u3082\u3063\u3066\u3044\u308b\u3068\u6210\u9577\u304c\u65e9\u304f\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306eEGFR\u3092\u6291\u3048\u308b\u3053\u3068\u3067\uff0c\u816b\u760d\u306e\u5897\u5927\u3092\u59a8\u3052\u3088\u3046\u3068\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u8a66\u307f\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u304f\u3055\u3093\u306e\u6cbb\u9a13 cetuximab, panitumumab, matuzumab, MDX-447, nimotuzumab, mAb806, erlotinib, gefitinib, EKB-569, lapatinib (GW572016), PKI-166, canertinib (CI-1033) \u304c\u3055\u308c\u307e\u3057\u305f\u304c\uff0c2018\u5e74\u306e\u6bb5\u968e\u3067\u306f\uff0c\u306f\u3063\u304d\u308a\u6709\u52b9\u6027\u304c\u78ba\u304b\u3081\u3089\u308c\u3066\u3053\u308c\u306f\u4f7f\u3048\u308b\u305e\u3068\u3044\u3046\u5370\u8c61\u306e\u3082\u306e\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u90e8\u3067\u56fd\u5916\u6cbb\u9a13\u306b\u53c2\u52a0\u3067\u304d\u308b\u3088\u3046\u3067\u3059\u304c\u3042\u307e\u308a\u304a\u52e7\u3081\u3067\u304d\u306a\u3044\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"color: #000080;\"><strong>IDH\u5909\u7570\u306e\u3042\u308b\u661f\u7d30\u80de\u816b\u306b\u306f\uff0c\u671f\u5f85\u306e\u65b0\u85ac\u304c\u767b\u5834\u3057\u307e\u3057\u305f\u3002<\/strong><\/span><span style=\"color: #000080;\"><strong>2023\u5e74\u306b\uff0c\u5909\u7570\u578bIDH\u963b\u5bb3\u5264\uff0c<span style=\"color: #ff0000;\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib\uff08\u98f2\u307f\u85ac\uff09<\/span>\u306e\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\uff0c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577<\/strong><\/span>\u304c\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\uff0c2025\u5e74\u306b\u306f\u65e5\u672c\u3067\u3082\u81e8\u5e8a\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059<\/p>\n<h5>\u6587\u732e<\/h5>\n<h4>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u81e8\u5e8a\u8a66\u9a13\u8ffd\u52a0\u5831\u544a<\/h4>\n<p>2024\u5e74\u672b\u306b\u7c73\u56fd\u8133\u816b\u760d\u5b66\u4f1aSNO\u3067\u767a\u8868\u304c\u3042\u308a\u307e\u3057\u305f\u3002INDIGO\u3068\u3044\u3046\u7b2c3\u76f8\u8a66\u9a13\u306e\u8ffd\u52a0\u3067\u3059\u3002\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u8ffd\u52a0\u52b9\u679c\u3068\u3057\u3066\uff0c\u6295\u4e0e\u3059\u308b\u3068\u60a3\u8005\u3055\u3093\u304c\u3066\u3093\u304b\u3093\u767a\u4f5c\u3092\u751f\u3058\u308b\u78ba\u7387\u304c\u4e0b\u304c\u308b\u305d\u3046\u3067\u3059\u3002\u307e\u305f\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u308b\u3068\u3044\u3046\u52b9\u679c\u3082\u3084\u306f\u308a\u306f\u3063\u304d\u308a\u898b\u3048\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u306e\u7d50\u679c\u3067\u3059\u3002<\/p>\n<h4><span class=\"title_default\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib\u306f\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u3068\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\uff1a\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c<\/span><\/h4>\n<p>Mellinghoff IK:\u00a0<span class=\"title_default\">Vorasidenib in IDH1- or IDH2-mutant low-Grade glioma. New Engl J Med 2023<br \/>\nvorasidenib\u306f\u3001\u5909\u7570\u578bIDH1\/2\u9175\u7d20\u306e\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3001\u816b\u760d\u306e2-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b0\u30eb\u30bf\u30eb\u9178\uff082-HG\uff09\u309290\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u7d4c\u53e3\u85ac\u3067\u3059\u304c\u8133\u5185\u79fb\u884c\u304c\u3088\u3044\u85ac\u5264\u3067\u3059\u3002\u8853\u5f8c\u306e\u6b8b\u5b58\u816b\u760d\u3042\u308b\u3044\u306f\u518d\u71c3 168\u4f8b\u306bvorasidenib (40 mg once daily) \u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502414.2\u30f6\u6708\u306e\u6642\u70b9\u3067\uff0c7\u5272\u306e\u60a3\u8005\u3055\u3093\u304cvorasidenib\u3042\u308b\u3044\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u7d99\u7d9a\u670d\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002PFS\u4e2d\u592e\u5024\u306f\uff0cvorasidenib\u306727.7\u30f6\u6708\uff0c\u30d7\u30e9\u30bb\u30dc\u306711.1\u30f6\u6708\u3067\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6709\u5bb3\u4e8b\u8c61\u306f22.8%\u3067\u307f\u3089\u308c\uff0cALT\u306e\u4e0a\u6607\u304c\u76ee\u7acb\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u4e2d\u6b62\u306f3.6%\u3067\u3057\u305f\u3002<\/span><\/p>\n<h4>DNA\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u3088\u308b\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u7fa4\u5225<\/h4>\n<p>Ceccarelli MMolecular Profiling Reveals Biologically Discrete Subsets and\u00a0Pathways\u00a0of\u00a0Progression\u00a0in\u00a0DiffuseGlioma.Cell.\u00a02016<br \/>\nIDH\u91ce\u751f\u578b\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de IDH-wild-type diffuse glioma \u306f\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b grade II \u3084\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b grade III \u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3084\u81a0\u82bd\u816b\u306b\u306e\u3053\u3068\u3082\u3042\u308a\u5f97\u307e\u3059\u3002\u3067\u3082\uff0c\u591a\u304f\u306f\u81a0\u82bd\u816b\u3068\u306a\u308b\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>\u3069\u3046\u3057\u305f\u3089\u6cbb\u305b\u308b\u304b\u5c06\u6765\u306e\u65b9\u5411\u306f\uff1f<\/h4>\n<p>Osswald M, et al.: Brain tumour cells interconnect to a functional and resistant network. Nature 528:93-98, 2015<br \/>\nNature\u8a8c\u3078\u306e\u5831\u544a\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u6700\u5927\u306e\u7279\u5fb4\u306f\u6d78\u6f64\u5897\u6b96\u80fd<\/strong><\/span> diffusely infiltrative growth \u3067\u3059\u3002\u816b\u760d\u5316\u3057\u305f\u661f\u7d30\u80de\u306f\u3068\u3066\u3082\u9577\u3044\u7d30\u80de\u819c\u7a81\u8d77\u3092\u4f38\u3070\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7279\u6709\u306e<strong><span style=\"color: #000080;\">\u9577\u3044\u30de\u30a4\u30af\u30ed\u30c1\u30e5\u30fc\u30d6\u3092\u4f7f\u3063\u3066\u816b\u760d\u7d30\u80de\u306f\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5f62\u6210<\/span><\/strong>\u3057\u3066\uff0c\u5897\u6b96\u3057\u3066\u6d78\u6f64\u3057\u3066\uff0c\u9060\u304f\u96e2\u308c\u305f\u816b\u760d\u7d30\u80de\u9593\u3067\u3082\u76f8\u4e92\u306b\u9023\u7d61\u3057\u307e\u3059\u3002\u30de\u30a4\u30af\u30ed\u30c1\u30e5\u30fc\u30d6\u3067\u9023\u7d50\u3055\u308c\u305f\u7d30\u80de\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u3088\u308b\u7d30\u80de\u6b7b\u306b\u62b5\u6297\u3057\u3066\u7d30\u80de\u4fee\u5fa9\u3059\u308b\u80fd\u529b\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002<span style=\"color: #000080;\"><strong>neuronal growth-associated protein 43<\/strong><\/span>\u3068\u3044\u3046\u86cb\u767d\u304c\u30de\u30a4\u30af\u30ed\u30c1\u30e5\u30fc\u30d6\u306e\u5f62\u6210\u3068\u6a5f\u80fd\u5236\u5fa1\uff0c\u6d78\u6f64\uff0c\u5897\u6b96\uff0c\u7d30\u80de\u9593\u9023\u7d61\uff0c\u653e\u5c04\u7dda\u62b5\u6297\u6027\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u89e3\u3063\u305f\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3059\u3002\u661f\u7d30\u80de\u3068\u306f\u7570\u306a\u308a\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u3067\u306f\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u30de\u30a4\u30af\u30ed\u30c1\u30e5\u30fc\u30d6\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h4><span class=\"style1 style2\" style=\"color: #000080;\">IDH\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u4e88\u5f8c\u304c\u826f\u3044<\/span><\/h4>\n<p>Yan H, et al.: DIH1 and IDH2 mutations in gliomas. N Engl J Med 360: 765-773, 2009<br \/>\nIDH (isocitrate dehydrogenase)\u3068\u3044\u3046\u9175\u7d20\u306e\u907a\u4f1d\u5b50\uff0cIDH1 (amino acid 132) \u3068IDH2 (aminoacid R172) \u304c\u591a\u304f\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u5909\u7570\u3092\u751f\u3058\u3066\u3044\u308b\u3068\u3044\u3046\u8ad6\u6587\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c9\uff12\u3068\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u661f\u7d30\u80de\u816b\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306770\uff05\u304f\u3089\u3044\u306b\u3042\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3067\u3042\u308a\uff0c\u30b0\u30ec\u30fc\u30c9\uff14\u306e\u81a0\u82bd\u816b\u3067\u306f\u30b0\u30ec\u30fc\u30c9\u306e\u4f4e\u3044\u661f\u7d30\u80de\u816b\u304b\u3089\u60aa\u6027\u5316\u3057\u305fsecondary glioblastoma\u306e\u307f\u306b\u898b\u3089\u308c\u307e\u3059\u3002 IDH\u5909\u7570\u306e\u3042\u308b\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b38\u4f8b\u3067\u306f\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c65\u30f6\u6708\uff0cIDH\u5909\u7570\u306e\u306a\u3044(wild type)\u3082\u306e14\u4f8b\u3067\u306f20\u30f6\u6708\u3068\u304b\u306a\u308a\u5927\u304d\u306a\u958b\u304d\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\n\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u4e88\u5f8c\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u6ce8\u76ee\u3059\u308b\u3079\u304d\u7d50\u679c\u3067\u3059\u3002\u9006\u306b\u907a\u4f1d\u5b50\u5909\u7570\u306e\u306a\u3044\u3082\u306e\u3067\u306f\u81a0\u82bd\u816b\u3068\u540c\u3058\u304f\u3089\u3044\u306e\u60aa\u6027\u5ea6\u306b\u306a\u308a\u307e\u3059\u304b\u3089\uff0c\u5c06\u6765\u7684\u306b\u306f\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u30b0\u30ec\u30fc\u30c9\u3092\u6c7a\u3081\u308b\u306e\u306b\u4f7f\u7528\u3055\u308c\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002Duke\u5927\u5b66\u304c\u4e2d\u5fc3\u3068\u306a\u3063\u305f\u7814\u7a76\u6210\u679c\u3067\u3059\u304c\uff0c\u672c\u5f53\u306b\u3053\u308c\u307b\u3069\u5927\u304d\u306a\u5dee\u304c\u3042\u308b\u306e\u304b\u3069\u3046\u304b\u78ba\u8a8d\u3055\u308c\u308b\u305f\u3081\u306b\u306f\u307e\u3060\u6642\u9593\u304c\u304b\u304b\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4><span class=\"style1 style2\" style=\"color: #000080;\">\u624b\u8853\u306b\u3088\u308b\u5b8c\u5168\u6458\u51fa ? \u304c\u81a0\u82bd\u816b\u306e\u751f\u5b58\u671f\u9593\u3092\u5ef6\u3070\u3059<\/span><\/h4>\n<p>Stummer W, et al. Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery 62: 1025-1034, 2008, Pichlmeier U, et al. Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol 10: 1025-1034, 2008\u3000\uff08\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306e\uff12\u3064\u306e\u8ad6\u6587\u3067\u3059\uff09<br \/>\n\u624b\u8853\u524d\u306eMRI\u3067\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u306e\u816b\u760d\u304c\u307b\u307c\u6458\u51fa\u3067\u304d\u308b\u3067\u3042\u308d\u3046\u3068\u8003\u3048\u3089\u308c\u305f243\u4eba\u306e\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u304c\u5bfe\u8c61\u3067\u3059\u3002122\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u5b8c\u5168\u6458\u51fa\uff08\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u306e\u5165\u308b\u767d\u3044\u90e8\u5206\u3060\u3051\u3067\u3059\uff09\u304c\u306a\u3055\u308c\u3066\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f16.7\u30f6\u6708\uff0c121\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u4e0d\u5b8c\u5168\u6458\u51fa\u306711.8\u30f6\u6708\u3067\u3057\u305f\u3002\u8457\u8005\u306fOxford Center EBM\u306e\u30ec\u30d9\u30eb2b\u306e\u7cbe\u5ea6\u3067\uff0c \u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u306e\u81a0\u82bd\u816b\u306e\u5b8c\u5168\u6458\u51fa\u304c\uff0c\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\uff0cRTOG-RPA\uff08\u5e74\u9f62\uff0cKPS\uff08\u4e00\u822c\u72b6\u614b\uff09\uff0c\u795e\u7d4c\u75c7\u72b6\uff0c\u8a8d\u77e5\u6a5f\u80fd\u306e\u8a55\u4fa1\u304b\u3089\u8a08\u7b97\u3055\u308c\u308b\u5206\u985e\uff09\u306e\u30af\u30e9\u30b9\uff14\u3068\uff15\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u5b8c\u5168\u6458\u51fa\u304c\u751f\u5b58\u671f\u9593\u3092\u660e\u3089\u304b\u306b\u5ef6\u9577\u3059\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e\u6cbb\u7642\u306f\uff0c\u3067\u304d\u308b\u9650\u308a\u305f\u304f\u3055\u3093\u306e\u816b\u760d\u3092\u5207\u9664\u3059\u308b (cytoreductive surgery, bulk-reduction surgery) \u3068\u3044\u3046\u958b\u982d\u624b\u8853\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002\u3067\u3082\u81a0\u82bd\u816b\u3092\u3069\u306e\u304f\u3089\u3044\u306e\u7a0b\u5ea6\u6458\u51fa\u3057\u305f\u3089\u751f\u5b58\u671f\u9593\u304c\u306f\u3063\u304d\u308a\u4f38\u3073\u308b\u304b\u3068\u3044\u3046\u3053\u3068\u306b\u306f\u79d1\u5b66\u7684\u306a\u7d50\u8ad6\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u8ad6\u6587\u3067\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u306e\u75c5\u5909\u3092\u78ba\u5b9f\u306b\u5207\u9664\u3059\u308b\u3068\uff0c\u751f\u5b58\u671f\u9593\u304c\uff15\u30f6\u6708\u7a0b\u5ef6\u3070\u305b\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3092\u793a\u3057\u3066\u307e\u3059\u3002<br \/>\n\u3068\u3066\u3082\u6ce8\u610f\u3057\u3066\u8aad\u307e\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u8ad6\u6587\u3067\u3059\u3002\u304a\u305d\u3089\u304f\u7d50\u8ad6\u304c\u62e1\u5927\u89e3\u91c8\u3055\u308c\u3066\u6b69\u304d\u56de\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\u5229\u76ca\u3092\u5f97\u3089\u308c\u305f\u60a3\u8005\u3055\u3093\u306f\u81a0\u82bd\u816bRTOG-RPA\u30af\u30e9\u30b9\uff14\u304b\uff15\u3067\uff0c\u624b\u8853\u524d\u306eMRI\u304b\u3089\u5b8c\u5168\u6458\u51fa\uff08\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u90e8\u5206\u306e\u307f\uff09\u304c\u3067\u304d\u308b\u3067\u3042\u308d\u3046\u3068\u4e88\u6e2c\u3055\u308c\uff0c\u91cd\u7be4\u306a\u75c7\u72b6\u3092\u51fa\u3055\u306a\u3044\u3067\u305d\u308c\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u6761\u4ef6\u3092\u3082\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u6761\u4ef6\u3092\u6e80\u305f\u3057\u305f\u4eba\u306e\u307f\u306b\u3053\u306e\u7d50\u8ad6\u304c\u9069\u5fdc\u3055\u308c\u5f97\u308b\u306e\u3067\u3059\u3002\u3053\u306e\u6761\u4ef6\u3092\u6e80\u305f\u3059\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u306f\u591a\u3044\u3068\u306f\u3044\u3048\u307e\u305b\u3093\u3002\u3067\u3059\u304b\u3089\uff0c\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306f\u624b\u8853\u3067\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\u3088\u308a\u751f\u5b58\u671f\u9593\u304c\u4f38\u3073\u308b\uff0c\u3068\u3044\u3046\u5927\u307e\u304b\u306a\u8a00\u8449\u306b\u5165\u308c\u66ff\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u6050\u308c\u307e\u3059\u3002<br \/>\n\u672c\u6765\uff0c\u81a0\u82bd\u816b\u3068\u3044\u3046\u816b\u760d\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u767d\u3044\u90e8\u5206\u3088\u308a\u306f\u308b\u304b\u306b\u5e83\u304f\u6d78\u6f64\u3057\u3066\u308b\u3082\u306e\u3067\u3059\u3002\u816b\u760d\u5916\u79d1\u5b66\u3067\u4f7f\u7528\u3055\u308c\u308b\u5b8c\u5168\u6458\u51fa complete removal \u3068\u3044\u3046\u8a00\u8449\u306f\u816b\u760d\u306e\u3059\u3079\u3066\u304c\u53d6\u308a\u9664\u304b\u308c\u308b\u3068\u8a00\u3046\u3053\u3068\u306a\u306e\u3067\uff0c\u6b63\u3057\u3044\u610f\u5473\u3067\u306f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u751f\u5b58\u671f\u9593\u306e\u6570\u30f6\u6708\u306e\u5ef6\u9577\u306f\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304c\uff0c\u6cbb\u7652\uff08\u6cbb\u308b\uff09\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u6709\u610f\u5dee\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u3002<br \/>\nKPS\uff08\u4e00\u822c\u72b6\u614b\uff09\u306e\u60aa\u3044\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u3068\u3044\u3046\u3053\u3068\u3082\u306f\u3063\u304d\u308a\u3057\u305f\u4e8b\u5b9f\u3067\u3059\u3002\u81a0\u82bd\u816b\u306e\u624b\u8853\u3067\u6700\u3082\u5927\u5207\u306a\u3053\u3068\u306f\uff0c\u6cbb\u308b\u898b\u8fbc\u307f\u304c\u3068\u3066\u3082\u4f4e\u3044\u304b\u3089\u3053\u305d\uff0c\u751f\u5b58\u306e\u8cea\u3092\u843d\u3068\u3055\u306a\u3044\u3088\u3046\u306a\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3067\u3059\u3002\u3067\u304d\u308b\u9650\u308a\u305f\u304f\u3055\u3093\u6458\u51fa\u3059\u308b\u3068\u3044\u3063\u3066\u3082\uff0c\u60a3\u8005\u3055\u3093\u306e\u72b6\u614b\uff08\u9ebb\u75fa\u3084\u8a8d\u77e5\u6a5f\u80fd\uff09\u3092\u60aa\u304f\u3059\u308b\u3088\u3046\u306a\u624b\u8853\u306f\u3057\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u771f\u306e\u610f\u5473\u3067\u306e\uff0c\u81a0\u82bd\u816b\u306e\u5b8c\u5168\u6458\u51fa\u306f\u4e0d\u53ef\u80fd\u306a\u306e\u3067\u3059\u304b\u3089\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h4>\u30b0\u30ea\u30d9\u30c3\u30af Gleevec, imatinib \u306b\u3064\u3044\u3066<\/h4>\n<p>Reardon DA , et al. : Phase II study of imatinib mesylate plus hydroxyurea in adult with recurrent glioblastoma multiforme. J Clin Oncol 23: 9359-9368, 2005<br \/>\n\u30c7\u30e5\u30fc\u30af\u5927\u5b66\u304c\u884c\u3063\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u5831\u544a\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u3063\u3066\uff0c\u3055\u3089\u306b\u518d\u767a\u3057\u3066\u3057\u307e\u3063\u305f\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u309333\u4eba\u306b\u30b0\u30ea\u30d9\u30c3\u30af\u304c\u4f7f\u308f\u308c\u307e\u3057\u305f\u3002\u30b0\u30ea\u30d9\u30c3\u30af400mg\uff08\u4e00\u65e5\uff11\u56de\uff09\u3068\u30cf\u30a4\u30c9\u30ec\u30a2500mg\uff08\u4e00\u65e5\uff12\u56de\uff09\u3092\u98f2\u3080\u6cbb\u7642\u3067\u3059\u3002\u3066\u3093\u304b\u3093\u3092\u6b62\u3081\u308b\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u3068\u30b0\u30ea\u30d9\u30c3\u30af\u306e\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u3067\uff0c\u305d\u306e\u3088\u3046\u306a\u60a3\u8005\u3055\u3093\u306f\u30b0\u30ea\u30d9\u30c3\u30af500mg\u3092\u4e00\u65e5\uff12\u56de\u98f2\u307f\u307e\u3057\u305f\u3002\u3053\u306e\u6cbb\u7642\u306f\u5916\u6765\u3067\u3067\u304d\u307e\u3059\u3057\uff0c\u526f\u4f5c\u7528\u306f\u6bd4\u8f03\u7684\u8efd\u3044\u9aa8\u9ac4\u6291\u5236\uff08\u767d\u8840\u7403\u3084\u8840\u5c0f\u677f\u306e\u6570\u304c\u6e1b\u308b\uff09\u3067\u3059\u3002\u8133\u306e\u6d6e\u816b\u304c\u60aa\u5316\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u7d50\u679c\u306f\uff0c\uff13\u4eba(9%)\u306e\u60a3\u8005\u3055\u3093\u3067\u816b\u760d\u304c\u7e2e\u5c0f\u3057\uff0c14\u4eba(42%)\u306e\u60a3\u8005\u3055\u3093\u3067\u816b\u760d\u306e\u5927\u304d\u304f\u306a\u308b\u306e\u304c\u4e00\u6642\u7684\u306b\u6b62\u307e\u308a\u307e\u3057\u305f\u300227%\u306e\u60a3\u8005\u3055\u3093\u3067\uff16\u30f6\u6708\u9593\u306f\u816b\u760d\u304c\u9032\u884c\u3059\u308b\u3053\u3068\u3092\u6b62\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u751f\u5b58\u7387\u306e\u4e2d\u592e\u5024\u306f49\u9031\u9593\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u534a\u5206\u306e\u60a3\u8005\u3055\u3093\u304c\uff11\u5e74\u304f\u3089\u3044\u306f\u751f\u5b58\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\n\u3053\u308c\u306f\u518d\u767a\u306e\u81a0\u82bd\u816b\u306e\u6cbb\u7642\u3068\u3057\u3066\u306f\u3068\u3066\u3082\u826f\u3044\u6210\u7e3e\u306a\u306e\u3067\u3059\u3002\u3067\u3082\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\uff0c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u5e74\u9f62\uff08\u4e2d\u592e\u5024\uff09\u304c52\u6b73\u3068\u82e5\u3044\u3053\u3068\u3068\u75c7\u72b6\u304c\u6bd4\u8f03\u7684\u8efd\u3044\u60a3\u8005\u3055\u3093\u3067\u3042\u3063\u305f\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u5bfe\u8c61\u7fa4\u3067\u306f\u6210\u7e3e\u306f\u5c11\u3057\u826f\u304f\u306a\u308b\u306e\u304c\u666e\u901a\u3067\u3059\u3002<br \/>\n<span style=\"color: #ff0000;\"><strong>\u305d\u306e\u5f8c\u306e\u5927\u304d\u306a\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u671f\u5f85\u3055\u308c\u305f\u52b9\u679c\u306f\u306a\u304b\u3063\u305f\u3088\u3046\u3067\u3059\u3002<\/strong><\/span><\/p>\n<h4>\u653e\u5c04\u6027\u7269\u8cea\u3092\u3064\u3051\u305f\u6297\u30c6\u30ca\u30b7\u30f3\u30fb\u30e2\u30ce\u30af\u30ed\u30ca\u30fc\u30eb\u6297\u4f53\u306b\u3064\u3044\u3066<\/h4>\n<p>Reardon DA et al.: Salvage Radioimmunotherapy with Murine Iodine-131-Labeled Antitenascin Monoclonal Antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. J Clin Oncol 24: 115-122, 2006<br \/>\n\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306ftenascin \u30c6\u30ca\u30b7\u30f3 \u3068\u3044\u3046\u7d44\u7e54\u9593\u8cea\u86cb\u767d\u3092\u3082\u3063\u3066\u3044\u3066\u305d\u308c\u304c81C6\u3068\u3044\u3046\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u8a8d\u8b58\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u305a\u3044\u3076\u3093\u524d\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u6297\u4f53\u306b\u653e\u5c04\u6027\u30e8\u30fc\u30c9\u3092\u304f\u3063\u3064\u3051\u3066\uff0c\u518d\u767a\u8133\u816b\u760d\u3092\u624b\u8853\u3057\u3066\u305d\u306e\u6458\u51fa\u8154\u306e\u4e2d\u306b\u6297\u4f53\u3092\u3044\u308c\u3066\u6cbb\u7642\u3092\u3057\u3088\u3046\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u6cbb\u7642\u306e\u5f8c\u3067\u6297\u304c\u3093\u5264\u304c\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u8ffd\u52a0\u3055\u308c\u3066\u3044\u307e\u3059\u3002Duke\u5927\u5b66\u3067\u518d\u767a\u3057\u305f43\u4eba\u306e\u60aa\u6027\u8133\u816b\u760d\u306e\u60a3\u8005\u3055\u3093\u3067\u306e\u6210\u7e3e\u3067\u3059\u3002\u81a0\u82bd\u816b\uff08\u30b0\u30ec\u30fc\u30c9\uff14\uff09\u306e\u60a3\u8005\u3055\u3093\u3067\uff11\u5e74\u751f\u5b58\u5272\u5408\u306f63%\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u60a3\u8005\u3055\u3093\u306759%\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\u305d\u308c\u305e\u308c64\u9031\u306899\u9031\u3068\u3044\u3046\uff0c\u3061\u3087\u3063\u3068\u9a5a\u304f\u3088\u3046\u306a\u826f\u3044\u6210\u7e3e\u3067\u3059\u3002<br \/>\n2006\u5e74\u306e\u8133\u816b\u760d\u306e\u56fd\u969b\u5b66\u4f1a\u3067\u4f1a\u3063\u305f\u6642\uff0c\u3053\u306e\u7814\u7a76\u306e\u4e2d\u5fc3\u306b\u306a\u3063\u3066\u3044\u308bBigner\u5148\u751f\u306f\u3068\u3066\u3082\u671f\u5f85\u3092\u3082\u3063\u3066\u3044\u308b\u3068\u8a71\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u7b2c\uff12\u5c64\u8a66\u9a13\u3084\u7b2c\uff13\u5c64\u8a66\u9a13\u304c\u8a08\u753b\u3055\u308c\u3066\u3044\u304f\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002<\/p>\n<h4>erlotinib Tarceva\u30bf\u30eb\u30bb\u30d0\u306b\u3064\u3044\u3066<\/h4>\n<p>Cloughesy A et al.: J Clin Oncol, 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement), 2005: 1507<br \/>\n\u518d\u767a\u81a0\u82bd\u816b\u306e41\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u4f7f\u7528\u3057\u30668.4%\u306b\u816b\u760d\u306e\u7e2e\u5c0f (CR+PR) \u304c\u3042\u3063\u305f\u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u60aa\u6027\u795e\u7d4c\u81a0\u816b\uff08\u7279\u306b\u81a0\u82bd\u816b\uff09\u306fEGFR\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u3092\u7d30\u80de\u8868\u9762\u306b\u3082\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u3092\u4ecb\u3057\u3066\u816b\u760d\u306e\u5897\u6b96\u304c\u65fa\u76db\u306b\u306a\u308b\u306e\u3067\u3059\u3002EGFR\u907a\u4f1d\u5b50\u306e\u5897\u5e45\uff0cEGFR\u86cb\u767d\u306e\u7523\u751f\u304c\u591a\u3044\uff0cpPKB?Akt\u306e\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\u306a\u3069\u306e\u81a0\u82bd\u816b\u3067\u306f\uff0cerlotinib\u304c\u6709\u52b9\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u63a8\u6e2c\u304c\u3042\u308a\u307e\u3059\u3002\u3067\u3082\u86cb\u767d\u3084\u907a\u4f1d\u5b50\u89e3\u6790\u3092\u3057\u3066\u3082\u81e8\u5e8a\u7684\u52b9\u679c\u306b\u306f\u3042\u307e\u308a\u306f\u3063\u304d\u308a\u3057\u305f\u5dee\u304c\u51fa\u3066\u3044\u307e\u305b\u3093\u3002erlotinib\u306f\u80ba\u304c\u3093\uff08\u975e\u5c0f\u7d30\u80de\u6027\uff09\u306e\u9818\u57df\u3067\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u308b\u5236\u764c\u5264\u3067\u3059\u3002\u80ba\u304c\u3093\u306b\u6709\u540d\u306agefitinib (\u30a4\u30ec\u30c3\u30b5\uff09\u3082\u540c\u69d8\u306a\u8003\u3048\u65b9\u3067\u4f7f\u308f\u308c\u308b\u5236\u764c\u5264\u3067\u3059\u3002<br \/>\n\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3067\u306e\u306f\u3063\u304d\u308a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u6210\u679c\u306f\u307e\u3060\u51fa\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h4>CPT-11 irinotecan\u306b\u3064\u3044\u3066<\/h4>\n<p>\u30a4\u30ea\u30ce\u30c6\u30ab\u30f3\u306f\u30ab\u30f3\u30d7\u30c8\u3068\u30c8\u30dd\u30c6\u30b7\u30f3\u3068\u3044\u3046\u5546\u54c1\u540d\u306e\u5236\u764c\u5264\u3067\u3059<br \/>\nPrados MD, et al: A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant gliomas: a North American Brain Tumor Consortium study. Neuro-oncol 8: 189-193, 2006<br \/>\n51\u4eba\u306e\u518d\u767a\u3057\u305f\u81a0\u82bd\u816b\u3042\u308b\u3044\u306f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002350mg\/m2\uff08\u3066\u3093\u304b\u3093\u306e\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u4eba\u306f750mg\/m2\uff09\u3092\uff13\u9031\u9593\u306b\u4e00\u5ea6\u9759\u8108\u5185\u6295\u4e0e\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u4e0b\u75e2\u3068\u9aa8\u9ac4\u6291\u5236\u304c\u6709\u5bb3\u4e8b\u8c61\u3067\u3057\u305f\u3002\u3053\u306e\u4f7f\u7528\u65b9\u6cd5\u3067\u7528\u3044\u305f\u9650\u308a\u3067\u306fCPT-11\u306f\u6709\u52b9\u3067\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3059\u3002<\/p>\n<h4>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u3068\u30a2\u30d0\u30b9\u30c1\u30f3\u306b\u3064\u3044\u3066<\/h4>\n<p>\u30b5\u30ea\u30c9\u30de\u30a4\u30c9 (thalidomide) \u3084\u30a2\u30d0\u30b9\u30c1\u30f3 (avastin, bevacizumab) \u306f\u60aa\u6027\u8133\u816b\u760d\u304c\u8840\u7ba1\u3092\u4f5c\u308b\u306e\u3092\u59a8\u3052\u3066\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u308b\u306e\u3092\u9632\u3054\u3046\u3068\u3044\u3046\u76ee\u7684\u3067\u4f7f\u308f\u308c\u308b\u5236\u764c\u5264\u3067\u3059\u3002\u30b5\u30ea\u30c9\u30de\u30a4\u30c9\u306f\u3082\u3068\u3082\u3068\u7761\u7720\u85ac\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u305f\u85ac\u3067\uff0cIGF\u3068\u304b\u3044\u308d\u3044\u308d\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u6291\u5236\u3057\u3066\u816b\u760d\u306e\u8840\u7ba1\u304c\u5897\u3048\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002\u30a2\u30d0\u30b9\u30c1\u30f3\u306fVEGF\uff08\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff09\u3068\u3044\u3046\u7269\u8cea\u306e\u50cd\u304d\u3092\u6291\u3048\u308b\u6297\u4f53\uff08\u666e\u901a\u306e\u85ac\u3068\u306f\u3061\u3087\u3063\u3068\u9055\u3046\u3082\u306e\uff09\u3067\u3059\u3002<br \/>\n\u4e21\u8005\u3068\u3082\u306b\u307e\u3060\u4fe1\u983c\u6027\u306e\u3042\u308b\u81e8\u5e8a\u7814\u7a76\u306e\u7d50\u679c\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u60a3\u8005\u3055\u3093\u500b\u4eba\u304c\u30cd\u30c3\u30c8\u3067\u8cfc\u5165\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u304a\u8a71\u3082\u805e\u304d\u307e\u3059\u304c\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u5358\u72ec\u3067\u518d\u767a\u3057\u305f\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306b\u6709\u52b9\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u306e\u3067\u6ce8\u610f\u3057\u3066\u4e0b\u3055\u3044\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/feeding.jpg\" rel=\"attachment wp-att-8504\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-8504\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/feeding-238x300.jpg\" alt=\"feeding\" width=\"238\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/feeding-238x300.jpg 238w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/feeding-477x600.jpg 477w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/feeding.jpg 566w\" sizes=\"auto, (max-width: 238px) 100vw, 238px\" \/><\/a><\/p>\n<h4 class=\"style2\"><strong><span style=\"color: #ff0000;\">\u91cd\u8981\u306a\u8c46\u77e5\u8b58\uff08generous local field)<\/span><\/strong><\/h4>\n<p>\u6d78\u6f64\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u306f\u753b\u50cf\u3067\u816b\u760d\u304c\u898b\u3048\u308b\u90e8\u4f4d\u3088\u308a\uff0c\u3060\u3044\u305f\u304420 mm\u304f\u3089\u3044\u5916\u5074\u307e\u3067\u30ab\u30d0\u30fc\u3059\u308b\u3088\u3046\u306a\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u306a\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3092generous local field\u3068\u3044\u3044\u307e\u3059\u304c\uff0c\u9069\u5207\u306a\u65e5\u672c\u8a9e\u3092\u601d\u3044\u3064\u304d\u307e\u305b\u3093\u30021980\u5e74\u306bHochberg\u5148\u751f\u304c\u6709\u540d\u306a\u8ad6\u6587\u3092\u66f8\u3044\u305f\u3053\u3068\u306b\u306f\u3058\u307e\u308a\u307e\u3059\u3002\u305d\u308c\u307e\u3067\u306f\u5168\u8133\u7167\u5c0440\u30b0\u30ec\u30a4\u3068\u3044\u3046\u6cbb\u7642\u304canaplastic astrocytoma\u3068glioblastoma\u306b\u306f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\uff0c\u3053\u308c\u3089\u306e\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e\u518d\u71c3 relapse\u306f\u816b\u760d\u306e\u5b58\u5728\u90e8\u4f4d\u304b\u308920 mm\u4ee5\u5185\u3067\u8d77\u3053\u308b\u306e\u3067\uff0c\u5168\u8133\u7167\u5c04\u306f\u5fc5\u8981\u306a\u3044\u3068\u8ad6\u3058\u305f\u306e\u3067\u3059\u3002<br \/>\n\u9006\u306b\u6016\u3044\u3053\u3068\u306b\u306f\uff0c\u3053\u306e\u8ad6\u6587\u3068\u6709\u540d\u306aWalker\u5148\u751f\u306e\u8ad6\u6587\u4ee5\u6765\uff0c\u5c40\u6240\u7167\u5c04\u306e\u8003\u3048\u65b9\u306b\u969b\u7acb\u3063\u305f\u9032\u6b69\u304c\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u73fe\u5728\u306f3\u6b21\u5143\u539f\u4f53\u7167\u5c04\uff08\u5f37\u5ea6\u5909\u8abf\u653e\u5c04\u7dda\u6cbb\u7642\u306a\u3069\uff09\u304c\u53ef\u80fd\u306a\u6642\u4ee3\u3067\u3059\u3002\u660e\u3089\u304b\u306b\u305d\u3053\u306b\u306f\u816b\u760d\u6d78\u6f64\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u6b63\u5e38\u8133\u3078\u306f\u7167\u5c04\u3092\u907f\u3051\u308b\u6280\u8853\u304c\u3042\u308b\u306e\u306b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u306a\u3044\u304b\u3089\u3068\u8a00\u3046\u3053\u3068\u3067\u4f7f\u7528\u3055\u308c\u306a\u3044\u77db\u76fe\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>Hochberg FH, Pruitt A. Assumptions in the radiotherapy of glioblastoma. Neurology 30: 907-11, 1980<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e8c\u3064\u306b\u5206\u985e\u3055\u308c\u3066\u3044\u3066\uff0c\u3053\u308c\u3092\u7528\u3044\u3066\u6cbb\u7642\u65b9\u6cd5\u304c\u6c7a\u307e\u308a\u307e\u3059, \u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u8a73\u3057\u3044\u8aac\u660e\u306b\u98db\u3073\u307e\u3059\uff0c\u305d\u3061\u3089\u3092\u8aad\u3093\u3060\u65b9\u304c\u3044\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093 \u661f\u7d30\u80de\u816b IDH\u5909\u7570\u578b astrocytoma IDH mutant\u3000\u30b0\u30ec\u30fc\u30c92,3,4 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-74","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/74","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=74"}],"version-history":[{"count":171,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/74\/revisions"}],"predecessor-version":[{"id":23155,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/74\/revisions\/23155"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=74"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=74"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=74"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}