{"id":6025,"date":"2014-07-14T09:23:05","date_gmt":"2014-07-14T00:23:05","guid":{"rendered":"\/sawamura\/?p=6025"},"modified":"2025-01-28T11:18:34","modified_gmt":"2025-01-28T02:18:34","slug":"opticpathwaypil","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/pediattumor\/opticpathwaypil\/","title":{"rendered":"\u8996\u795e\u7d4c\u81a0\u816b\uff0c\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff0c\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b optic glioma, optic pathway glioma, hypothalamic\/optic pathway pilocytic astrocytoma"},"content":{"rendered":"<ul>\n<li>\u4e00\u822c\u7684\u306b\u306f\u5358\u7d14\u306b\u8996\u795e\u7d4c\u81a0\u816b <span style=\"color: #000080;\"><strong>optic glioma<\/strong><\/span>\u3068\u547c\u3070\u308c\u307e\u3059<\/li>\n<li>\u8996\u795e\u7d4c\uff0c\u8996\u4ea4\u53c9\uff0c\u8996\u5e8a\u4e0b\u90e8\uff0c\u8996\u7d22\u3001\u5185\u5305\uff0c\u8996\u653e\u7dda\u307e\u3067\u3092\u4fb5\u3059\u816b\u760d\u3067\u3059<\/li>\n<li>\u6b63\u78ba\u306b\u306f<span style=\"color: #000080;\"><strong>\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/strong><\/span> <strong><span style=\"color: #000080;\">hypothalamic\/optic pathway pilocytic astrocytoma<\/span><\/strong>\u3068\u3044\u3046\u3082\u306e\u3067\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u6d78\u6f64\u3068\u8996\u5e8a\u4e0b\u90e8\u75c7\u72b6\u3092\u5408\u4f75\u3059\u308b\u3082\u306e\u304c\u591a\u3044\u304b\u3089\u3067\u3059<\/li>\n<li><span style=\"color: #000000;\"><span style=\"color: #ff0000;\"><strong>\u8d64\u3061\u3083\u3093\u304b\u3089\u5c0f\u3055\u3044\u5b50\u3069\u3082<\/strong><\/span>\u306b\u591a\u3044\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #000000;\">\u7247\u773c\u306e<\/span><strong>\u8996\u529b\u304c\u60aa\u304f\u306a\u308b<\/strong><\/span>\u3053\u3068\u3067\u6c17\u3065\u304b\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000000;\">\u4e21\u76ee\u304c\u4fb5\u3055\u308c\u308b\u3053\u3068\u3082<\/span>\u3042\u308a\u307e\u3059<\/li>\n<li>\u8d64\u3061\u3083\u3093\u3060\u3068\uff0c<strong><span style=\"color: #000080;\">\u773c\u304c\u63fa\u308c\u308b<\/span><\/strong> pendular nystagmus \u3068\u3044\u3046\u75c7\u72b6\u3067\u3059\u304c\uff0c\u305d\u306e\u6642\u306b\u306f\u3082\u3046\u304b\u306a\u308a\u8996\u529b\u304c\u60aa\u304f\u306a\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #333333;\">\u4e73\u5e7c\u5150\u3067\u8996\u5e8a\u4e0b\u90e8\u306b\u3053\u306e\u816b\u760d\u304c\u3042\u308b\u3068\uff0c\u30ac\u30ea\u30ac\u30ea\u306b\u75e9\u305b\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff08\u9593\u8133\u75c7\u5019\u7fa4\uff09<\/span><\/li>\n<li><strong><span style=\"color: #000080;\">MRI<\/span><span style=\"color: #000080;\">\u3060\u3051\u3067\u8a3a\u65ad\u304c\u3064\u304d\u307e\u3059<\/span><\/strong><\/li>\n<li><span style=\"color: #333333;\">\u624b\u8853\u3067\u3061\u3087\u3063\u3068\u816b\u760d\u3092\u53d6\u3063\u3066\u75c5\u7406\u3092\u78ba\u304b\u3081\u308b\u3068\u3044\u3046\uff0c<\/span><span style=\"color: #ff0000;\"><strong>\u751f\u691c\u8853\u306f\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li><span style=\"color: #000080;\"><strong>\u75c5\u7406\u8a3a\u65ad\u306e\u305f\u3081\u306b\u624b\u8853\u3092\u52e7\u3081\u308b\u533b\u5e2b\u306f\u3053\u306e\u75c5\u6c17\u306e\u3053\u3068\u3092\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u3068\u601d\u3044\u307e\u3059<\/strong><\/span><\/li>\n<li>\u75c5\u7406\u306f\uff0c\u5c0f\u3055\u3044\u5b50\u3069\u3082\u3067\u306f<a href=\"\/sawamura\/pediattumor\/pilos\/\"><span style=\"color: #000080;\"><strong>\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c91<\/strong>\u00a0pilomyxoid astrocytoma<\/span><\/a> \u3067\u3059<\/li>\n<li>\u5e74\u9577\u3055\u3093\u304b\u3089\u601d\u6625\u671f\u306f\uff0c<a href=\"\/sawamura\/pediattumor\/pilos\/\"><span style=\"color: #000080;\"><strong>\u6bdb\u69d8\u7d30\u80de\u6027<\/strong><strong>\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c91<\/strong>\u00a0pilocytic astrocytomad<\/span><\/a><span style=\"color: #000080;\">\u3067\u3059<\/span><\/li>\n<li><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u795e\u7d4c\u7dda\u7dad\u816b\u75c7 NF-1, NF-2\" href=\"\/sawamura\/braintumors\/neurofibromatosis\/\"><span style=\"color: #000080;\">\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\uff11\u578b NF-1<\/span><\/a><\/span><\/strong>\u306b\u3067\u304d\u308b\u3082\u306e\u306f\uff0c\u6cbb\u7642\u3057\u306a\u304f\u3066\u3082\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u3082\u306e\u304c\u591a\u3044\u306e\u3067\u6c17\u3092\u3064\u3051\u3066\u304f\u3060\u3055\u3044<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6210\u4eba\u306b\u306a\u3063\u3066\u767a\u898b\u3055\u308c\u8996\u91ce\u6b20\u640d\u304c\u3042\u308b\u3082\u306e\u306f<\/strong><\/span>\uff0c\u5168\u304f\u5897\u5927\u3057\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u306e\u3067\uff0c\u5b89\u6613\u306b\u958b\u982d\u624b\u8853\u3067\u751f\u691c\u306a\u3069\u306f\u3057\u306a\u3044\u3067\u3059\uff0c\u7d4c\u904e\u89b3\u5bdf\u306e\u307f\u3067\u6e08\u3080\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u6cbb\u7642\u306f\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\uff09\u304c\u4e2d\u5fc3<\/strong><\/span>\u306b\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n<h4>\u753b\u50cf\u306e\u7279\u5fb4<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/654b9e772af6a7b785e068077ef23263.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7806\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/654b9e772af6a7b785e068077ef23263-200x200.jpg\" alt=\"\u6e15\u91ce06.7.3T2axi\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/44c3d7fc317c9d1d600e2913ab487a79.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7807\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/44c3d7fc317c9d1d600e2913ab487a79-200x200.jpg\" alt=\"\u6e15\u91ce06.7.3T1axi\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/05d4f2b5f311ff7b7c79c18ebe88dd99.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7808\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/05d4f2b5f311ff7b7c79c18ebe88dd99-200x200.jpg\" alt=\"\u6e15\u91ce06.7.3T1sag\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/05d4f2b5f311ff7b7c79c18ebe88dd99-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/05d4f2b5f311ff7b7c79c18ebe88dd99-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/05d4f2b5f311ff7b7c79c18ebe88dd99.jpg 352w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>\u5e7c\u5150\u306e\u8996\u8def\u306e\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\u3067\u3059\u3002T2\u5f37\u8abf\u753b\u50cf\uff08\u5de6\u5074\uff09\u3067\u767d\u304f\u9ad8\u4fe1\u53f7\u306b\u5199\u308b\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3067\u306f\u307e\u3060\u3089\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\uff0c\u5747\u4e00\u306b\u771f\u3063\u767d\u306b\u9ad8\u4fe1\u53f7\u306b\u306a\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3059\u3002\u4e73\u5e7c\u5150\u306e\u3082\u306e\u306f\uff0c\u30c9\u30ed\u30c9\u30ed\u306b\u67d4\u3089\u304b\u3044\u816b\u760d\u3067\u3059\u3002<\/p>\n<h4>\u8996\u8def optic pathway\u306e\u89e3\u5256\u5b66<\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/opticpath-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-21597\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/opticpath-1-550x579.jpg\" alt=\"\" width=\"550\" height=\"579\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/opticpath-1-550x579.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/opticpath-1-285x300.jpg 285w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/opticpath-1.jpg 709w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<ol>\n<li>\u8996\u899a\u60c5\u5831\u306f\uff0c\u773c\u7403\u7db2\u819c\u306b\u5165\u3063\u3066\uff0c<span style=\"color: #000080;\"><strong>\u773c\u7aa9\u5185\u306e\u8996\u795e\u7d4c<\/strong><\/span>\u3092\u901a\u3063\u3066\uff0c\u982d\u84cb\u5185\u306b\u5165\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u982d\u84cb\u5185\u8996\u795e\u7d4c<\/span><\/strong>\u306f\u3068\u3066\u3082\u77ed\u3044\u3067\u3059<\/li>\n<li>\u4e21\u5074\u306e\u8996\u795e\u7d4c\u304c\u4ea4\u308f\u308b\u6240\u3092<span style=\"color: #000080;\"><strong>\u8996\u4ea4\u5dee<\/strong><\/span>\u3068\u3088\u3073\u307e\u3059<\/li>\n<li>\u8996\u4ea4\u5dee\u304b\u3089\u307e\u305f\u5de6\u53f3\u306b\u5206\u304b\u308c\u3066\uff0c<span style=\"color: #000080;\"><strong>\u8996\u7d22<\/strong><\/span>\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u8996\u7d22\u306f<span style=\"color: #000080;\"><strong>\u5916\u5074\u819d\u72b6\u4f53<\/strong><\/span>\u3068\u3044\u3046\u3068\u3053\u308d\u3067\u8133\u306e\u4e2d\u306b\u5165\u308a\u307e\u3059<\/li>\n<li>\u305d\u3053\u304b\u3089\u306f<strong><span style=\"color: #000080;\">\u5185\u5305\u5f8c\u811a<\/span><\/strong>\uff0c<strong><span style=\"color: #000080;\">\u8996\u653e\u7dda<\/span><\/strong>\u3092\u4f1d\u308f\u3063\u3066\uff0c<strong><span style=\"color: #000080;\">\u5f8c\u982d\u8449<\/span><\/strong>\u307e\u3067\u884c\u304d\u307e\u3059<\/li>\n<li>\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\u4e0a\u8a18\u306e\u3069\u3053\u3067\u3082\u767a\u751f\u3057\u307e\u3059<\/li>\n<li>\u3053\u306e<span style=\"color: #000080;\"><strong>\u8996\u8def\u306b\u6cbf\u3063\u3066\u6d78\u6f64\u3057\u3066\u5e83\u304c\u308a\u307e\u3059<\/strong><\/span><\/li>\n<\/ol>\n<h4>\u75c7\u72b6<\/h4>\n<ul>\n<li>\u4e73\u5e7c\u5150\u306f\u8996\u529b\u306e\u4f4e\u4e0b\u3092\u8a34\u3048\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u305b\u3093\uff0c\u3067\u3059\u304b\u3089\u304b\u306a\u308a\u8996\u529b\u304c\u60aa\u304f\u306a\u3063\u3066\u304b\u3089\u6c17\u3065\u304b\u308c\u307e\u3059<\/li>\n<li>5\u6b73\u5150\u304f\u3089\u3044\u3067\u3082\u898b\u3048\u306a\u304f\u306a\u308b\u5bf8\u524d\u307e\u3067\u8a00\u308f\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u5e7c\u7a1a\u5712\u3084\u5c0f\u5b66\u6821\u306e\u691c\u8a3a\u3067\u8996\u529b\u304c\u60aa\u3044\u3053\u3068\u3092\u6307\u6458\u3055\u308c\u307e\u3059<\/li>\n<li>\u4e73\u5e7c\u5150\u3067\u306f\u659c\u8996\u3068\u8a3a\u65ad\u3055\u308c\u308b\u306e\u3067\u3059\u304c\uff0c\u4e21\u5074\u306e\u8996\u529b\u304c\u60aa\u304f\u306a\u308b\u3068<span style=\"color: #000080;\"><strong>\u659c\u8996<\/strong><\/span>\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u8996\u529b\u304c\u304b\u306a\u308a\u4f4e\u4e0b\u3059\u308b\u3068\u773c\u304c\u63fa\u308c\u308b\u3088\u3046\u306a\u52d5\u304d\u3092\u3057\u307e\u3059 (<span style=\"color: #000080;\"><strong>\u632f\u308a\u5b50\u69d8\u773c\u632f pendular nystagmus<\/strong><\/span>)<\/li>\n<li>\u5168\u76f2\u5bf8\u524d\u3067\u767a\u898b\u3055\u308c\u308b\u3053\u3068\u3082\u591a\u3044\u306e\u3067\u6cbb\u7642\u3092\u6025\u304e\u307e\u3059<\/li>\n<li>\u958b\u982d\u624b\u8853\u3067\u4f59\u5206\u306a\u90e8\u5206\u6458\u51fa\u306a\u3069\u3057\u3066\u3044\u308b\u3068\uff0c\u6642\u9593\u3092\u5931\u3044\uff0c\u5168\u76f2\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059<\/li>\n<li>\u5927\u304d\u306a\u816b\u760d\u3067\u306f\uff0c\u7b2c\uff13\u8133\u5ba4\u4e0a\u90e8\u306e\u30e2\u30f3\u30ed\u30fc\u5b54\u306e\u9589\u585e\u306e\u305f\u3081\u306b<span style=\"color: #000080;\"><strong>\u9589\u585e\u6027\u6c34\u982d\u75c7<\/strong><\/span>\u3068\u306a\u308a<span style=\"color: #000080;\"><strong>\u5614\u5410\u3084\u610f\u8b58\u969c\u5bb3<\/strong><\/span>\u3067\u767a\u75c7\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u3053\u306e\u6642\u306f\uff0c\u900f\u660e\u4e2d\u6838\u3092\u958b\u7a93\u3057\u3066\u30b7\u30e3\u30f3\u30c8\u624b\u8853\u3092\u3057\u3066\u304b\u3089\uff0c\u5316\u5b66\u7642\u6cd5\u306b\u304b\u304b\u308a\u307e\u3059<\/li>\n<li>\u4e73\u5150\u3067\u306f\u30ac\u30ea\u30ac\u30ea\u306b\u75e9\u305b\u308b\u3068\u3044\u3046\u75c7\u72b6\u3067\u767a\u898b\u3055\u308c\u307e\u3059\uff0c\u3053\u308c\u3092<span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/hypothdysfunction\/\"><strong><span style=\"color: #000080;\">\u9593\u8133\u75c7\u5019\u7fa4 diencephalic syndrome<\/span>\u00a0<\/strong><span style=\"color: #333333;\">\u3068\u3044\u3044\u307e\u3059\uff08\u5225\u306a\u30da\u30fc\u30b8\u306b\u8a73\u3057\u304f\u66f8\u3044\u3066\u3042\u308b\u306e\u3067\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/span><\/a><\/span><\/li>\n<\/ul>\n<h4><strong>\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u90e8\u4f4d\u5206\u985e<br \/>\n<\/strong>\u3053\u308c\u3067\u6cbb\u7642\u306e\u65b9\u5411\u6027\u304c\u6c7a\u307e\u308a\u307e\u3059<\/h4>\n<h5>1.\u3000\u773c\u7aa9\u5185\u8996\u795e\u7d4c\u81a0\u816b intraorbital optic glioma<\/h5>\n<p>\u7247\u65b9\u306e\u8996\u795e\u7d4c\u304b\u3089\u3067\u308b\u3082\u306e\u3067\uff0c\u773c\u7aa9\u5185\u3067\u5897\u5927\u3057\u307e\u3059\u304b\u3089\uff0c\u624b\u8853\u6458\u51fa\u3067\u6cbb\u308a\u307e\u3059\u304c\u7247\u773c\u306e\u8996\u529b\u3092\u5931\u3044\u307e\u3059\u3002\u5316\u5b66\u7642\u6cd5\u304c\u3042\u307e\u308a\u52b9\u304d\u307e\u305b\u3093\u3002\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306b\u591a\u3044\u30bf\u30a4\u30d7\u3067\u3059\u3002<\/p>\n<p><span style=\"color: #000080;\"><strong>\u773c\u7aa9\u5185\u5358\u8996\u795e\u7d4c\u81a0\u816b<\/strong><\/span><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21606\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop-300x298.jpg\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop-550x546.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop-768x763.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpreop.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21607\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop-300x288.jpg\" alt=\"\" width=\"300\" height=\"288\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop-300x288.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop-550x528.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop-768x737.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkpostop.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>1\u6b73\u5150\u306e\u5de6\u773c\u7aa9\u5185\u5358\u8996\u795e\u7d4c\u81a0\u816b\u3067\u3059\u3002\u5de6\u76ee\u306f\u624b\u52d5\u5f01\u7a0b\u5ea6\u3067\u3059\u304b\u3089\uff0c\u5168\u6458\u51fa\u3057\u307e\u3057\u305f\u3002\u307e\u3076\u305f\u306e\u52d5\u304d\u3068\u773c\u7403\u904b\u52d5\u306f\u6e29\u5b58\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u4f8b\u306b\u4f55\u5e74\u3082\u5316\u5b66\u7642\u6cd5\u3092\u7d9a\u3051\u308b\u306e\u306f\u99ac\u9e7f\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21608\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital-300x281.jpg\" alt=\"\" width=\"300\" height=\"281\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital-300x281.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital-550x515.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital-768x719.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintraorbital.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a> <a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21609\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial-300x275.jpg\" alt=\"\" width=\"300\" height=\"275\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial-300x275.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial-550x503.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial-768x703.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilotkintracranial.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u5de6\u306e\u5199\u771f\u306f\uff0c\u5de6\u773c\u7aa9\u5185\u816b\u760d\uff0c\u53f3\u306e\u5199\u771f\u306f\uff0c\u982d\u84cb\u5185\u306e\u6b63\u5e38\u5de6\u8996\u795e\u7d4c\u3067\u3059\u3002<\/p>\n<h5>2.\u3000\u5358\u795e\u7d4c\u8996\u795e\u7d4c\u81a0\u816b single optic nerve glioma<\/h5>\n<p>\u982d\u84cb\u5185\u3067\u3057\u3070\u3057\u3070\u5de8\u5927\u306a\u816b\u760d\u3068\u306a\u308a\u8996\u4ea4\u53c9\u306b\u5c11\u3057\u5165\u308a\u307e\u3059<br \/>\n\u5927\u304d\u304f\u306a\u308b\u3068\u753b\u50cf\u8a3a\u65ad\u304c\u96e3\u3057\u304f\uff0c\u8996\u4ea4\u53c9\u3082\u4fb5\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u307f\u3048\u307e\u3059\u304c\uff0c\u8996\u91ce\u691c\u67fb\u304c\u8a3a\u65ad\u3092\u88dc\u52a9\u3057\u307e\u3059\u304b\u3089\uff0c\u5e7c\u5150\u3067\u3082\u304c\u3093\u3070\u3063\u3066\u8996\u91ce\u691c\u67fb\u3057\u307e\u3059<br \/>\n\u773c\u7aa9\u5185\u3068\u982d\u84cb\u5185\u306b\u3042\u308a\u307e\u3059\u304c\u7247\u65b9\u306e\u8996\u795e\u7d4c\u3060\u3051\u3092\u4fb5\u3057\u307e\u3059\u304b\u3089\uff0c<strong><span style=\"color: #ff0000;\">\u624b\u8853\u6458\u51fa\u3067\u304d\u308b\u3082\u306e<\/span><\/strong>\u3067\u3059<\/p>\n<p><strong><span style=\"color: #000080;\">\u982d\u84cb\u5185\u5358\u8996\u795e\u7d4c\u81a0\u816b<\/span><\/strong><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21601\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4-300x291.jpg\" alt=\"\" width=\"300\" height=\"291\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4-300x291.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4-550x533.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4-768x744.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosilefteye08.4.jpg 984w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21602\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10-300x293.jpg\" alt=\"\" width=\"300\" height=\"293\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10-300x293.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10-550x537.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10-768x750.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosirighteye08.10.jpg 984w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><span style=\"color: #333333;\">2\u6b73\u306e\u3068\u304d\u53f3\u773c\u306e\u5931\u660e\u3067\u767a\u75c7\u3057\u5316\u5b66\u7642\u6cd5\u304c\u7d99\u7d9a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f8\u6b73\u306e\u6642\u306e\u8996\u91ce\u691c\u67fb\u3067\u3059\u3002\u6570\u30f6\u6708\u306e\u7d4c\u904e\u3067\u5de6\u773c\u3082\u8033\u5074\u534a\u76f2\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u624b\u8853\u524d\u306e\u8996\u91ce\u691c\u67fb\u3067\uff0c\u3053\u306e\u816b\u760d\u304c\u53f3\u8996\u795e\u7d4c\u304b\u3089\u767a\u751f\u3057\uff0c\u5de6\u773c\u306f\u816b\u760d\u306b\u4fb5\u3055\u308c\u305a\uff0c\u305f\u3093\u306b\u5727\u8feb\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u5358\u8996\u795e\u7d4c\u81a0\u816b\u3067\u3059\u3002<\/span><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21603\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1-300x291.jpg\" alt=\"\" width=\"300\" height=\"291\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1-300x291.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1-550x533.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1-768x745.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosmpre1.jpg 1112w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-21604\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost-287x300.jpg\" alt=\"\" width=\"287\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost-287x300.jpg 287w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost-550x575.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost-768x802.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosipost.jpg 1073w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/a><\/p>\n<p>\u5316\u5b66\u7642\u6cd5\u3092\u9577\u304f\u53d7\u3051\u305f\u816b\u760d\u306f\u5de8\u5927\u3067\u3057\u305f\u3002\u3053\u306e\u816b\u760d\u3092\u4e9c\u5168\u6458\u51fa\u3057\u307e\u3057\u305f\u3002\u5e78\u3044\u5de6\u773c\u306e\u8996\u91ce\u306f\u6539\u5584\u3057\u3066\u8996\u5e8a\u4e0b\u90e8\u4e0b\u5782\u4f53\u969c\u5bb3\u3082\u3067\u307e\u305b\u3093\u3067\u3057\u305f\u30022\u6b73\u306e\u6642\u306b\u958b\u982d\u624b\u8853\u3067\u5168\u6458\u51fa\u3059\u308b\u3079\u304d\u3082\u306e\u3067\u3057\u305f\u3002<\/p>\n<h5>3.\u3000\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b optic pathway \/ hypothalamic pilocytic astrocytoma<\/h5>\n<p>\u6700\u3082\u591a\u3044\u91cd\u8981\u306a\u30bf\u30a4\u30d7\u3067\uff0c\u4e3b\u3068\u3057\u3066\u8996\u4ea4\u53c9\u304b\u3089\u8996\u5e8a\u4e0b\u90e8\u3078\u3082\u6d78\u6f64\u3059\u308b\u3082\u306e\u3067\u3059<br \/>\n<strong><span style=\"color: #ff0000;\">\u5316\u5b66\u7642\u6cd5\u304c\u6cbb\u7642\u624b\u6bb5<\/span><\/strong>\u306e\u4e2d\u5fc3\u3067\u3059<br \/>\n\u5316\u5b66\u7642\u6cd5\u62b5\u6297\u6027\uff0c\u3042\u308b\u3044\u306f\u306e\u3046\u80de\u6027\u62e1\u5927\u306a\u3069\u306e\u5834\u5408\u306b\u3088\u3063\u3066\uff0c\u6e1b\u8377\u624b\u8853 debulking surgery \u306e\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u96e3\u3057\u3044\u3082\u306e\u3067\u3059<\/p>\n<h5>4.\u3000\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b hypothalamic pilocytic astrocytoma<\/h5>\n<p>\u8996\u4ea4\u53c9\u306e\u5f8c\u4e0a\u90e8\u304b\u3089\u767a\u751f\u3057\u307e\u3059\u304c\uff0c\u4e3b\u3068\u3057\u3066\u8996\u5e8a\u4e0b\u90e8\u3092\u4fb5\u3057\u3066\u7b2c\uff13\u8133\u5ba4\u816b\u760d\u3068\u3057\u3066\u9593\u8133\u75c7\u5019\u7fa4\u3067\u767a\u75c7\u3057\u307e\u3059\uff0c\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3068\u540c\u3058\u8003\u3048\u65b9\u3067\u6cbb\u7642\u3057\u307e\u3059<br \/>\n\u7b2c\uff13\u8133\u5ba4\u816b\u760d\u3068\u3057\u3066\u5897\u5927\u3057\u305f\u3082\u306e\u306f\uff0c1\u5ea6\u306e\u958b\u982d\u624b\u8853\u6458\u51fa\u3060\u3051\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff0c\u305f\u3060\u3057\u8907\u6570\u56de\u624b\u8853\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/p>\n<h5>5.\u3000\u8996\u7d22\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b optic-tract pilocytic astrocytoma<\/h5>\n<p>\u7247\u5074\u306e\u8996\u7d22\u306b\u9650\u5c40\u3057\u3066\u767a\u751f\u5897\u5927\u3059\u308b\u3082\u306e\u3067\u3059<br \/>\n\u540c\u540d\u534a\u76f2\u3068\u3044\u3046\u7279\u5fb4\u7684\u306a\u75c7\u72b6\u306e\u307f\u3067\u7d4c\u904e\u3057\u307e\u3059<br \/>\n\u5916\u5074\u819d\u72b6\u4f53\u306b\u53ca\u3076\u3053\u3068\u304c\u591a\u304f\uff0c\u6458\u51fa\u306f\u6975\u3081\u3066\u56f0\u96e3\u3067\u3059<br \/>\n\u5e74\u9577\u5150\u3067\u306f\u534a\u5b9a\u4f4d\u5206\u5272\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u826f\u3044\u9069\u5fdc\u3068\u306a\u308b\u3082\u306e\u3067\u3059<\/p>\n<h5>6.\u3000\u5168\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b whole\u00a0optic pathway pilocytic astrocytoma<\/h5>\n<p>\u584a\u3068\u3057\u3066\u306e\u816b\u760d\u304c\u76ee\u7acb\u305f\u306a\u3044\u306e\u306b\uff0c\u4e21\u5074\u8996\u795e\u7d4c\u304b\u3089\u8996\u4ea4\u5dee\u3001\u8996\u7d22\uff0c\u5916\u5074\u819d\u72b6\u4f53\uff0c\u5185\u5305\u5f8c\u811a\uff0c\u8996\u653e\u7dda\uff0c\u8996\u5e8a\u4e0b\u90e8\uff0c\u8996\u5e8a\u306a\u3069\u306b\u6d78\u6f64\u3059\u308b\u3082\u306e\u3067\uff0c<span style=\"color: #ff0000;\"><strong>\u5316\u5b66\u7642\u6cd5\u3060\u3051<\/strong><\/span>\u304c\u6cbb\u7642\u624b\u6bb5\u3067\u3059<\/p>\n<h5>whole optic pathway pilocytic astrocytoma\u3068\u306f<\/h5>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay9.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7925\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay9-200x200.jpg\" alt=\"piloay9\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay10.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7926\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay10-200x200.jpg\" alt=\"piloay10\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay11.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7927\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay11-200x200.jpg\" alt=\"piloay11\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay12.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7928\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay12-200x200.jpg\" alt=\"piloay12\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay13.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7929\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay13-200x200.jpg\" alt=\"piloay13\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7930\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1-200x200.jpg\" alt=\"piloay1\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1-550x552.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay1.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay6.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7931\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay6-200x200.jpg\" alt=\"piloay6\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7932\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay5-200x200.jpg\" alt=\"piloay5\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7933\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2-200x200.jpg\" alt=\"piloay2\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2-550x547.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay2.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>\u4e21\u5074\u306e\u773c\u7aa9\u5185\u8996\u795e\u7d4c\u304b\u3089\u8996\u4ea4\u53c9\u3001\u8996\u7d22\uff0c\u5916\u5074\u819d\u72b6\u4f53\uff0c\u5185\u5305\u5f8c\u811a\uff0c\u8996\u653e\u7dda\u8fd1\u4f4d\u90e8\u307e\u3067\u304c\u816b\u760d\u5316\u3057\u3066\u3044\u307e\u3059\u3002FLAIR\u3067\u9ad8\u4fe1\u53f7\u3067\uff0c\u4e0d\u898f\u5247\u306b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3092\u624b\u8853\u6458\u51fa\u3057\u305f\u308a\u751f\u691c\u3057\u305f\u308a\u3057\u3066\u3082\u7121\u99c4\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u4e0d\u53ef\u80fd\u3067\u3042\u308a<span style=\"color: #000080;\"><strong>\u6cbb\u7642\u65b9\u6cd5\u306f\u5316\u5b66\u7642\u6cd5\u306e\u307f<\/strong><\/span>\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-8250\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay21-200x200.jpg\" alt=\"piloay2\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay21-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay21-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-8251\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay14-200x200.jpg\" alt=\"piloay1\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay14-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay14-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-8252\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay3-200x200.jpg\" alt=\"piloay3\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay3-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-8253\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay4-200x200.jpg\" alt=\"piloay4\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay4-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloay4-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\n\u3053\u306e\u5b50\u306fCDDP\/VCR\u306e\u5316\u5b66\u7642\u6cd5\u304b\u3089\u958b\u59cb\u3057\u306612\u5e74\u306b\u306a\u308a\u307e\u3059\u304c\uff0c\u4eca\u306f\u7121\u6cbb\u7642\u3067\u308f\u305a\u304b\u306a\u8996\u529b\u3067\u3059\u304c\u5b66\u6821\u306b\u901a\u3063\u3066\u3044\u307e\u3059\u3002\u512a\u7b49\u751f\u3067\u3059\u3002\u81ea\u7136\u9000\u7e2e\u3092\u898b\u3066\u3044\u307e\u3059\u304c\uff0c\u4eca\u5f8c\u3082\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u306f\u3059\u3053\u3057\u6b8b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><span style=\"color: #ff0000;\">\u751f\u691c\u624b\u8853\u3092\u8a08\u753b\u3057\u306a\u3044<br \/>\n\u4e73\u5150\u306e\u3082\u306e\u306f\u5927\u304d\u304f\u306a\u308b\u306e\u304c\u65e9\u3044<\/span><\/h3>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks1.jpg\" rel=\"attachment wp-att-8741\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8741 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks1-284x300.jpg\" alt=\"piloks1\" width=\"284\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks1-284x300.jpg 284w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks1-550x580.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks1.jpg 709w\" sizes=\"auto, (max-width: 284px) 100vw, 284px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks2.jpg\" rel=\"attachment wp-att-8742\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8742 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks2-283x300.jpg\" alt=\"piloks2\" width=\"283\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks2-283x300.jpg 283w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks2-550x583.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks2.jpg 709w\" sizes=\"auto, (max-width: 283px) 100vw, 283px\" \/><\/a><\/p>\n<p>\u751f\u5f8c\uff17\u30ab\u6708\u306e\u5e7c\u5150\u3067\u3059\u3002\u76ee\u304c\u63fa\u308c\u308b\u3088\u3046\u306b\u306a\u308a\uff08\u632f\u308a\u5b50\u69d8\u773c\u632f\uff09\u773c\u79d1\u3092\u53d7\u8a3a\u3057\u3066\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u5c0f\u5150\u8133\u816b\u760d\u306e\u6cbb\u7642\u304c\u3067\u304d\u308b\u75c5\u9662\u3078\u3068\u7d39\u4ecb\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks31.jpg\" rel=\"attachment wp-att-8746\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8746 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks31-290x300.jpg\" alt=\"piloks31\" width=\"290\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks31-290x300.jpg 290w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks31-550x569.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks31.jpg 709w\" sizes=\"auto, (max-width: 290px) 100vw, 290px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks4.jpg\" rel=\"attachment wp-att-8744\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8744 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks4-282x300.jpg\" alt=\"piloks4\" width=\"282\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks4-282x300.jpg 282w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks4-550x586.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloks4.jpg 709w\" sizes=\"auto, (max-width: 282px) 100vw, 282px\" \/><\/a><\/p>\n<p>1\u30f6\u6708\u5f8c\u306b\u307e\u305fMRI\u691c\u67fb\u304c\u3055\u308c\u307e\u3057\u305f\u3002\u4e73\u5150\u3067\u3059\u304b\u3089\u691c\u67fb\u306b\u3082\u9ebb\u9154\u304c\u5fc5\u8981\u3067\u3059\u3002<strong><span style=\"color: #000080;\">\u816b\u760d\u306f\u660e\u3089\u304b\u306b\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/strong>\u5de6\u8996\u795e\u7d4c\u304b\u3089\u8996\u7d22\u306e\u816b\u760d\u5316\u304c\u8457\u3057\u3044\u306e\u3067\u53f3\u5074\u3060\u3051\u304b\u3059\u304b\u306b\u8996\u529b\u304c\u6b8b\u3063\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u8996\u529b\u306f\u660e\u304b\u308a\u304c\u308f\u304b\u308b\u7a0b\u5ea6\uff08\u660e\u6697\u5f01\uff09\u3068\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u4e3b\u6cbb\u533b\u306e\u5148\u751f\u304b\u3089\u3053\u306e\u8d64\u3061\u3083\u3093\u306e\u4e21\u89aa\u306b\u624b\u8853\u304c\u63d0\u6848\u3055\u308c\u307e\u3057\u305f\u3002\u7406\u7531\u306f\uff0c\u300c\u3068\u3063\u3066\u307f\u306a\u3051\u308c\u3070\u3069\u3093\u306a\u816b\u760d\u304b\u308f\u304b\u3089\u306a\u3044\uff0c\u75c5\u7406\u8a3a\u65ad\u304c\u3067\u304d\u306a\u3044\u3068\u5236\u764c\u5264\uff08\u5316\u5b66\u7642\u6cd5\uff09\u304c\u9078\u629e\u3067\u304d\u306a\u3044\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<br \/>\n\u3053\u3093\u306a\u3053\u3068\u3092\u66f8\u304f\u306e\u306f\u60aa\u3044\u3053\u3068\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\uff0c\u307e\u3063\u305f\u304f\u99ac\u9e7f\u3052\u305f\u63d0\u6848\u3067\u3059\u3002\u3053\u306e\u753b\u50cf\u306f\u3069\u3053\u3092\u3069\u3046\u898b\u3066\u3082\u8996\u8def\u304b\u3089\u767a\u751f\u3057\u305f\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\u3067\u3059\u3002\u753b\u50cf\u306fpathognomonic\uff08\u65e5\u672c\u8a9e\u3067\u706b\u3092\u898b\u308b\u3088\u308a\u3082\u660e\u3089\u304b\uff09\u3067\u3059\u3002\u3053\u306e\u5c0f\u3055\u306a\u5b50\u306b\uff0c\u5168\u8eab\u9ebb\u9154\u3092\u3057\u3066\u958b\u982d\u624b\u8853\u3067\u751f\u691c\u75c5\u7406\u8a3a\u65ad\u3059\u308c\u3070\uff0c\u305d\u308c\u3060\u3051\u30673\u9031\u9593\u306f\u5316\u5b66\u7642\u6cd5\u306e\u958b\u59cb\u304c\u9045\u308c\u307e\u3059\u3002\u305d\u306e\u9593\u306b\u660e\u304b\u308a\u3082\u898b\u3048\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3046\uff08\u5b8c\u5168\u5931\u660e\u3059\u308b\uff09\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3057\u3087\u3046\u30022021\u5e74\u6642\u70b9\u3067\u3082\uff0c\u958b\u982d\u624b\u8853\u306b\u3088\u308b\u751f\u691c\u8853\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u3093\u306a\u91cd\u75c5\u306e\u5c0f\u3055\u306a\u5b50\u3069\u3082\u306e\u982d\u3092\u7121\u7528\u306b\u958b\u304f\u306a\u3069\uff0c\u79c1\u306b\u306f\u3082\u3046\u7406\u89e3\u4e0d\u80fd\u3067\u3059\u3002<br \/>\n\u3053\u306e\u69d8\u306a\u5897\u6b96\u529b\u304c\u65e9\u3044\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\u306f\uff0c\u9ac4\u6db2\u64ad\u7a2e\uff08\u8133\u810a\u9ac4\u306b\u5e83\u7bc4\u56f2\u306b\u8ee2\u79fb\uff09\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u624b\u8853\u3067\u7d30\u80de\u3092\u6563\u3089\u305b\u3070\u81f4\u547d\u7684\u306a\u64ad\u7a2e\u3092\u8a98\u767a\u3059\u308b\u53ef\u80fd\u6027\u3055\u3048\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3><strong><span style=\"color: #ff0000;\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u81ea\u7136\u6b74<\/span> <span style=\"color: #000080;\">natural history\uff08<\/span><\/strong>\u5e74\u9f62\u306b\u3088\u308b\u816b\u760d\u306e\u6027\u8cea\u5909\u5316\uff09<\/h3>\n<h4><strong>in infant\u30000\u6b73\u304b\u30895\u6b73<\/strong><\/h4>\n<h5>pilomyxoid type<br \/>\nrapid tumor growth, CSF dissemination<\/h5>\n<h4><strong>in very young children\u3000\uff14\u6b73\u304b\u308910\u6b73<\/strong><\/h4>\n<h5>continuous growth of tumor<br \/>\nworsening of vision and hormonal function<\/h5>\n<h4><strong>in young children\u30008\u969b\u304b\u308916\u6b73<\/strong><\/h4>\n<h5>growth arrest and\/or regrowth<br \/>\ncystic degeneration and expansion<\/h5>\n<h4><strong>in adolescent\u300016\u6b73\u4ee5\u4e0a<\/strong><\/h4>\n<h5>spontaneous involution<\/h5>\n<h4><strong>in adult\u300020\u6b73\u4ee5\u4e0a<\/strong><\/h4>\n<h5>quiet tumor residue<\/h5>\n<p>\u5c0f\u5150\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\u4e0d\u601d\u8b70\u306a\u816b\u760d\u3067\u3059\u3002\u60a3\u5150\u306e\u8133\u306e\u6210\u9577\u3068\u3068\u3082\u306b\u5897\u5927\u3057\uff0c\u3084\u304c\u3066<span style=\"color: #ff0000;\"><strong>\u81ea\u7136\u9000\u7e2e\u3059\u308b\u6642\u671f\uff08\u307b\u3063\u3068\u3044\u3066\u3082\u6cbb\u308b\uff09<\/strong><\/span>\u304c\u304d\u307e\u3059\u3002<\/p>\n<p><span style=\"color: #000080;\"><strong>\u4e73\u5e7c\u5150\u6642\u671f<\/strong><\/span>\u306b\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u50cf\u304c\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\u3067\uff0cMRI T2\u3067\u5747\u4e00\u306a\u9ad8\u4fe1\u53f7\u306b\u306a\u308a\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5f37\u304f\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u816b\u760d\u306e\u5897\u5927\u901f\u5ea6\u306f\u901f\u304f\uff0c\u7a00\u306b\u306f\u9ac4\u6db2\u64ad\u7a2e\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u305d\u308c\u304c\u816b\u760d\u6b7b\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u594f\u52b9\u7387\u306e\u9ad8\u3044\u5316\u5b66\u7642\u6cd5\u3092\u65e9\u304f\u958b\u59cb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u5c11\u3057\u7d4c\u904e\u3057\u3066<span style=\"color: #000080;\"><strong>\u5e7c\u5150\u671f<\/strong><\/span>\u306b\u306f\uff0c\u901f\u5ea6\u306f\u843d\u3061\u308b\u304c\u3084\u306f\u308a\u816b\u760d\u306f\u5897\u5927\u50be\u5411\u3092\u305f\u3069\u308a\u816b\u760d\u5185\u306e\u3046\u80de\u5f62\u6210\u3068\u306e\u3046\u80de\u306e\u62e1\u5927\u3092\u307f\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u3053\u306e\u6642\u671f\u306b\u3082\u75c7\u72b6\u306e\u60aa\u5316\u304c\u591a\u304f\uff0c\u5316\u5b66\u7642\u6cd5\u306f\u7d99\u7d9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002pilomyxoid type\u304b\u3089juvenile type pilocytic astrocytoma\u3078\u75c5\u7406\u7d44\u7e54\u50cf\u304c\u5909\u308f\u3063\u3066\u3044\u304d\u307e\u3059\u3002<br \/>\n<span style=\"color: #000080;\"><strong>\u5b66\u7ae5\u671f<\/strong><\/span>\u3067\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u304c\u594f\u52b9\u3059\u308c\u3070\u816b\u760d\u306e\u5897\u5927\u304c\u6b62\u307e\u308b\u304b\uff0c\u3042\u308b\u3044\u306f\u307e\u305f\u3086\u3063\u304f\u308a\u3068\u518d\u5897\u5927\u3057\u307e\u3059\u3002\u305d\u308c\u3068\u306f\u5225\u306b\uff0c\u816b\u760d\u5b9f\u8cea\u304c\u5897\u5927\u305b\u305a\u306b\uff0c\u816b\u760d\u306e\u3046\u80de\u306e\u307f\u304c\u62e1\u5927\u3059\u308b\u3068\u3044\u3046\u73fe\u8c61\u304c\u751f\u3058\u307e\u3059\u3002<span style=\"color: #ff0000;\"><strong>\u306e\u3046\u80de\u62e1\u5927\u306f oncolytic cyst \u3068\u547c\u3070\u308c\u308b<\/strong><\/span>\u3088\u3046\u306a\u816b\u760d\u5909\u6027\u306b\u4f34\u3046\u3082\u306e\u3067\u3042\u308a\uff0c\u5316\u5b66\u7642\u6cd5\u3092\u884c\u306a\u3063\u3066\u3082\u306e\u3046\u80de\u62e1\u5927\u3092\u6b62\u3081\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u3067\u3059\u3002\u624b\u8853\u306b\u3088\u308b\u306e\u3046\u80de\u58c1\u90e8\u5206\u6458\u51fa\u304c\u3068\u306a\u308b\u6642\u671f\u3067\u3082\u3042\u308a\u307e\u3059\u3002<br \/>\n<span style=\"color: #000080;\"><strong>\u601d\u6625\u671f<\/strong><\/span>\u306b\u306a\u308b\u3068\uff0c\u6cbb\u7642\u3092\u52a0\u3048\u306a\u304f\u3066\u3082\u816b\u760d\u306f\u5897\u5927\u50be\u5411\u3092\u505c\u6b62\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3057\u3087\u3046\u3002\u3053\u306e\u6642\u671f\u307e\u3067\u306e\u9577\u5e74\u306b\u308f\u305f\u3063\u3066\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u3068\u306a\u308b\u3068\u8003\u3048\u3066\uff0c\u521d\u671f\u6cbb\u7642\u306b\u5f53\u305f\u308b\u3053\u3068\u304c\u809d\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u81ea\u7136\u9000\u7e2e\u3068\u3044\u3046\u816b\u760d\u306e\u7e2e\u5c0f\u50be\u5411\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u306a\u308a\u307e\u3059\u3002<br \/>\n<span style=\"color: #000080;\"><strong>\u6210\u4eba<\/strong><\/span>\u3067\u306f\uff0c\u5897\u5927\u3057\u306a\u3044mass\u3068\u3057\u3066\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u307e\u3059\u3002T2\u5f37\u8abf\u753b\u50cf\u3067\u308f\u305a\u304b\u306a\u9ad8\u4fe1\u53f7\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u307b\u3068\u3093\u3069\u5897\u5f37\u3055\u308c\u306a\u3044\uff0c\u7121\u6cbb\u7642\u3067\u7d4c\u904e\u89b3\u5bdf\u3057\u3066\u3082\u5168\u304f\u5909\u5316\u304c\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3067\u3042\u308b\u306e\u3067\uff0c\u8996\u91ce\u6b20\u640d\u306a\u3069\u306e\u75c7\u72b6\u304c\u3042\u3063\u3066\u3082\uff0c\u3053\u306e\u3088\u3046\u306a\u3082\u306e\u3092\u7591\u3048\u3070\u751f\u691c\u624b\u8853\u3082\u305b\u305a\u306b\u7d4c\u904e\u306e\u307f\u3092\u307f\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3059\u3002<\/p>\n<h1>\u6cbb\u7642\u306e\u5927\u5207\u306a\u8003\u3048\u65b9<\/h1>\n<ul>\n<li>\u9ad8\u30ea\u30b9\u30af\u624b\u8853\u3067\u5168\u6458\u51fa\u3067\u304d\u308b\u6a5f\u4f1a\u306f\u5c11\u306a\u304f\uff0c<span style=\"color: #ff0000;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u30fb\u9593\u8133\u4e0b\u5782\u4f53\u6a5f\u80fd\u4f4e\u4e0b\u306a\u3069\u306e\u91cd\u7be4\u306a\u9045\u767a\u6027\u969c\u5bb3<\/strong><\/span>\u304c\u5371\u60e7\u3055\u308c\u307e\u3059\u3002<\/li>\n<li>\u3067\u3059\u304b\u3089\u300c\u5316\u5b66\u7642\u6cd5\u3060\u3051\u3067\u306a\u3093\u3068\u304b\u3057\u3088\u3046\u300d\u3068\u3044\u3046\u306e\u304c\u5c0f\u5150\u79d1\u533b\u306e\u8003\u3048\u3067\u3059\u3002<\/li>\n<li>\u3057\u304b\u3057\uff0c\u300c<span style=\"color: #ff0000;\"><strong>\u3053\u306e\u816b\u760d\u306f\u5316\u5b66\u7642\u6cd5\u3067\u6cbb\u7652\u3059\u308b\u3053\u3068\u304c\u306a<\/strong>\u3044<\/span>\u300d\u3068\u304f\u3089\u3044\u306b\u8003\u3048\u3066\u304a\u3044\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/li>\n<li>\u521d\u671f\u6cbb\u7642\u3067\u5bdb\u89e3\u5c0e\u5165\uff0c\u7dad\u6301\u5316\u5b66\u7642\u6cd5\uff0c\u7d4c\u904e\u89b3\u5bdf\uff0c\u518d\u71c3\uff0c\u5316\u5b66\u7642\u6cd5\u518d\u958b\uff0c\u958b\u982d\u816b\u760d\u6458\u51fa\u8853&#8212;&#8211;\u3092\u969b\u9650\u306a\u304f\u7e70\u308a\u8fd4\u3057\u307e\u3059\u3002<\/li>\n<li>\u6cbb\u7642\u671f\u9593\u306f10\u5e74\u3092\u8d85\u3048\u308b\u3053\u3068\u304c\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u5341\u6570\u5e74\u3068\u601d\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n<li>\uff11\u7a2e\u985e\u306e\u5316\u5b66\u7642\u6cd5\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u6e08\u3080\u3053\u3068\u306f\u307e\u305a\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<li>\u3055\u307e\u3056\u307e\u306a\u5316\u5b66\u7642\u6cd5\u3092\u3068\u3063\u304b\u3048\u3072\u3063\u304b\u3048\u7d9a\u3051\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<li>\u601d\u6625\u671f\u3092\u8d85\u3048\uff0c\u6210\u4eba\u306b\u8fd1\u3065\u304d\u81ea\u7136\u5bdb\u89e3\u306e\u6642\u671f\u3092\u671f\u5f85\u3057\u3066\uff0c\u4f55\u5e74\u3082\u4f55\u5e74\u3082\u9811\u5f35\u308b\u306e\u3067\u3059\u304c\uff0c\u305d\u3046\u306f\u884c\u304b\u306a\u304f\u3066\uff0c\u5236\u5fa1\u304c\u304d\u304b\u305a\u816b\u760d\u5897\u5927\u3067\u6b7b\u4ea1\u3059\u308b\u5b50\u4f9b\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<li>20\u6b73\u3092\u8d85\u3048\u3066\u3082\u816b\u760d\u5897\u5927\u304c\u7d9a\u304d\uff0c\u4ea1\u304f\u306a\u308b\u60a3\u8005\u3055\u3093\u3082\u3044\u307e\u3059\u3002<\/li>\n<li>\u4e73\u5e7c\u5150\u306b\u767a\u75c7\u3057\uff0c20\u5e74\u304f\u3089\u3044\u306e\u7d4c\u904e\u3092\u898b\u306a\u3044\u3068\uff0c\u3053\u306e\u75c5\u6c17\u306e\u672c\u5f53\u306e\u985b\u672b\u3092\u7406\u89e3\u3067\u304d\u306a\u3044\u3053\u3068\u3092\u8003\u3048\u3066\u6cbb\u7642\u306b\u3042\u305f\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n<li>\u6570\u5e74\u3067\u52dd\u8ca0\u304c\u3064\u304f\u6cbb\u7642\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u907f\u3051\uff0c\u6642\u306b\u306f\u5916\u79d1\u7684\u5e72\u6e09\u3092\u8e8a\u8e87\u305b\u305a\u306b\u884c\u3044\u306a\u304c\u3089\uff0c\u5316\u5b66\u7642\u6cd5\u3092\u7d99\u7d9a\u3057\u307e\u3059\u3002<\/li>\n<li>\u5927\u304d\u306a\u816b\u760d\u3067\u306f\uff0c20%\u304f\u3089\u3044\u306e\u60a3\u5150\u306b\u6c34\u982d\u75c7\u3092\u5408\u4f75\u3057\u307e\u3059<\/li>\n<\/ul>\n<h5>\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u3068\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306e\u65e5\u672c\u3067\u306e\u6cbb\u9a13\u3068\u4f7f\u7528\uff082024\u5e74\uff09<\/h5>\n<ul>\n<li><strong><span style=\"color: #000080;\">\u5f93\u6765\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u306e\u3082\u306e\u306b\u306f\uff0cBRAF\u963b\u5bb3\u5264\u306e\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\uff08\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6)\u3068\u30e1\u30ad\u30cb\u30b9\u30c8\uff08\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff09\u306e\u4f75\u7528\u6295\u4e0e\u304c\u4fdd\u967a\u8a3a\u7642\u3067\u3067\u304d\u307e\u3059<\/span><\/strong><\/li>\n<li><span style=\"color: #333333;\">BRAF v600\u907a\u4f1d\u5b50\u306b\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\uff0c<\/span><strong><span style=\"color: #000080;\">\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\u30ab\u30d7\u30bb\u30eb\uff08<\/span><\/strong><strong style=\"color: #000080;\">\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\uff0cBRAF\u963b\u5bb3\u5264\uff09\uff0c\u30e1\u30ad\u30cb\u30b9\u30c8\u9320\uff08<\/strong><strong style=\"color: #000080;\">\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff0cMEK\u963b\u5bb3\u5264\uff09<\/strong><span style=\"color: #333333;\">\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3082\u306e\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">2023\u5e74\u6642\u70b9\u3067\u3082\u3063\u3068\u3082\u671f\u5f85\u3092\u6301\u3063\u3066\u81e8\u5e8a\u4f7f\u7528\u304c\u3055\u308c\u3066\u3044\u308b\u6a19\u7684\u6cbb\u7642\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u3067\u3082<span style=\"color: #000080;\"><strong>BRAF\u5909\u7570\u306f\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e3 &#8211; 10%\u304f\u3089\u3044\u306b\u3057\u304b\u306a\u3044<\/strong><\/span>\u3067\u3059<\/span><\/li>\n<\/ul>\n<ul>\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">BRAF v600\u5909\u7570\u304c\u3042\u308b\u816b\u760d\u3092\u6709\u3059\u308b15\u6b73\u4ee5\u4e0b\u306e\u5c0f\u5150\u306b\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u30fb\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u6295\u4e0e\u3057\u307e\u3059<\/span><\/span><\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u6cbb\u9a13\u306f\uff0c\u6749\u5c71\u672a\u5948\u5b50\u5148\u751f\u304c\u62c5\u5f53\u8005\u3067\u3059<\/span><\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/ct.ganjoho.jp\/category\/ttrial\/jRCTs011220017\">RAF V600\u5909\u7570\u967d\u6027\u5c40\u6240\u9032\u884c\u30fb\u8ee2\u79fb\u6027\u5c0f\u5150\u56fa\u5f62\u816b\u760d\u306b\u5bfe\u3059\u308b\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u30fb\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306e\u7b2cII\u76f8\u8a66\u9a13\u3000\uff08jRCTs011220017\uff09<br \/>\n\uff08\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u958b\u304d\u307e\u3059\uff09<\/a><\/span><\/h5>\n<h3><strong>\u5316\u5b66\u7642\u6cd5\u306b\u3064\u3044\u3066<\/strong><\/h3>\n<h4><strong>\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3<\/strong><\/h4>\n<p>Sawamura Y, et al.: Chemotherapy with cisplatin and vincristine for optic pathway\/hypothalamic astrocytoma in young children. Jpn J Clin Oncol 39: 277-283, 2009<br \/>\n\u5165\u9662\u304c\u5fc5\u8981\u3067\u3059\u304c\u5207\u308c\u5473\uff08\u594f\u529f\u5272\u5408 75%\uff0c\u816b\u760d\u7e2e\u5c0f\u7387\uff09\u306f\u826f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u5927\u304d\u306a\u816b\u760d\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\uff0c\u521d\u56de\u6cbb\u7642\u306b\u7528\u3044\u3066\u5408\u8a08\uff16\u30b3\u30fc\u30b9\u3057\u307e\u3059\u3002<br \/>\n\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306f\u8074\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u308b\u306e\u3067\u7981\u5fcc\u3067\u3042\u308b\u3068\u3044\u3046\u610f\u898b\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u305d\u308c\u306f\u3080\u3084\u307f\u306b\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u3092\u9ad8\u304f\u3057\u3059\u304e\u308b\u304b\u3089\u3067\u3059\uff0c\u5c11\u91cf\u9577\u6642\u9593\u6295\u4e0e\u3059\u308c\u3070\u554f\u984c\u3042\u308a\u307e\u305b\u3093\u3002\u4eca\u307e\u3067100\u4f8b\u3092\u8d85\u3048\u308b\u5b50\u4f9b\u305f\u3061\u306b\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3092\u7528\u3044\u3066\u304d\u307e\u3057\u305f\u304c\uff0c\u3042\u3063\u3066\u3082\u9ad8\u97f3\u57df\u8074\u529b\u4f4e\u4e0b\u306e\u307f\u3067\u4f1a\u8a71\u57df\u3067\u306e\u8074\u529b\u969c\u5bb3\u3092\u7d4c\u9a13\u3057\u305f\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u30021\u6b73\u3067\u3082\u983b\u56de\u306e\u8074\u529b\u691c\u67fb\u30684000Hz\u4ee5\u4e0a\u306e\u9818\u57df\u4f4e\u4e0b\u3067\u306e\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306e\u9069\u5207\u306a\u6e1b\u91cf\u3092\u884c\u3046\u3068\u3044\u3046\u614e\u91cd\u3055\u304c\u3042\u308c\u3070\u3067\u304d\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n<h5>\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3 20 mg\/m2\/day day 1-5 div<br \/>\n\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3 1.4 mg\/m2\/day days 1,8,15 iv<\/h5>\n<h5>\uff12\u6b73\u672a\u6e80\u306e\u4e73\u5e7c\u5150\u306f\u6b21\u306e\u3088\u3046\u306b\u3057\u307e\u3059<br \/>\n\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3 0.7 mg\/kg\/day day 1-5 24hr div<br \/>\n\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3 0.05 mg\/kg\/day days 1,8,15 iv<\/h5>\n<hr \/>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/34b9cf841a424bcc66eb3d256c741eef1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7811\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/34b9cf841a424bcc66eb3d256c741eef1-200x200.jpg\" alt=\"pioks1\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/8057b089da2b35261895d916a5ad5524.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7810\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/8057b089da2b35261895d916a5ad5524-200x200.jpg\" alt=\"piloks2\" width=\"200\" height=\"200\" \/><br \/>\n<\/a><\/p>\n<p>\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u306a\u306e\u306f\uff0c\u4e0a\u306e\u753b\u50cf\u306e\u3088\u3046\u306b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3067\u5f37\u304f\u5897\u5f37\u3055\u308c\u308b\u30bf\u30a4\u30d7\u3067\u3059\uff0c\u307e\u305fT2\u5f37\u8abf\u753b\u50cf\u3067\u5f37\u3044\u9ad8\u4fe1\u53f7\u306b\u306a\u308b\u3082\u306e\u307b\u3069\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3059\uff0c\u8981\u3059\u308b\u306b\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\u306e\u8981\u7d20\u306b\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7813\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/4f7b96b943ae714073696445b69b1944-200x200.jpg\" alt=\"pilonr2\" width=\"200\" height=\"200\" \/><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/83124b6b53914be512e79737b967e02b1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-7814\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/83124b6b53914be512e79737b967e02b1-200x200.jpg\" alt=\"pilonr1\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>\u3053\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u307b\u3068\u3093\u3069\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\uff08\u53f3\u5074\u306eMRI\uff09\u304b\u3089\uff0c\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u3066\u3082\u5c0f\u3055\u304f\u306a\u308a\u307e\u305b\u3093\u306e\u3067\uff0c\u624b\u8853\u6458\u51fa\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\uff0c\u5b9f\u969b\u306b\u8996\u5e8a\u4e0b\u90e8\u304b\u3089\u767a\u751f\u3057\u305f\u3082\u306e\u8996\u4ea4\u53c9\u304c\u72af\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u624b\u8853\u4e9c\u5168\u6458\u51fa\u3067\u304d\u307e\u3057\u305f<\/p>\n<h4><strong>\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3<\/strong><\/h4>\n<p>Packer RJ, et al: Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 1997;86:747\u2013754<br \/>\n<span style=\"color: #ff0000;\"><strong>\u4e16\u754c\u3067\u6700\u3082\u5e83\u304f\u521d\u671f\u6cbb\u7642\u306b\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059<\/strong><\/span>\u3002\u5165\u9662\u3057\u3066\u3059\u308b\u3053\u3068\u3082\u5916\u6765\u6295\u4e0e\u3082\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u5c0e\u5165\u5316\u5b66\u7642\u6cd5\u3067\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3 175 mg\/m2 weekly (weeks 1-4, 7-10) \u3068 \u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3 1.5 mg\/m2 weekly iv (weeks 1-10) \u309210\u9031\u9593\u4f7f\u3063\u3066\uff0c\u5f8c\u306f\u540c\u3058\u3088\u3046\u306a\u65b9\u6cd5\u30674\u9031\u9593\u6cbb\u7642\u3057\u3066\uff13\u9031\u9593\u306e\u4f11\u85ac\u671f\u9593\u3092\u304a\u3044\u3066\uff0c\u6700\u5927\u306712\u30b3\u30fc\u30b9\u307e\u3067\u6cbb\u7642\u3092\u7d9a\u3051\u308b\u3068\u3044\u3046\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n<p>\u6700\u521d\u306e\u8ad6\u6587\u3067\u306f\uff0c\u9032\u884c\u6027\u306e\u60aa\u6027\u5ea6\u306e\u4f4e\u3044\u795e\u7d4c\u81a0\u816b\u306b\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u304c\uff0c\u304b\u306a\u308a\u306e\u75c7\u4f8b\u304c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u300278\u4eba\u306e\u5b50\u4f9b\u306e\u3046\u306144\u4eba(56%)\u3067\u816b\u760d\u304c\u5ba2\u89b3\u7684\u306b\u5c0f\u3055\u304f\u306a\u3063\u305f\u3068\u3044\u3046\u6210\u7e3e\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u3053\u306e\u5316\u5b66\u7642\u6cd5\u306f\uff0c\u5916\u6765\u3067\u3067\u304d\u308b\u3057\uff0c\u6709\u52b9\u6027\uff08\u594f\u529f\u5272\u5408 60-70%\uff09\u3082\u9ad8\u304f\u3066\uff0c\u305f\u304f\u3055\u3093\u306e\u75c7\u4f8b\u3067\u8a3c\u660e\u3055\u308c\u3066\u3044\u3066\uff0c\u3044\u308d\u3044\u308d\u306a\u65bd\u8a2d\u3067\u8ffd\u8a66\u3055\u308c\u3066\u3082\u4fe1\u7528\u6027\u304c\u3042\u3063\u3066\uff0c\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u3068\u3057\u3066\u4e16\u754c\u306b\u5e83\u307e\u308a\u307e\u3057\u305f\u3002\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3092\u9577\u304f\u4f7f\u3046\u3068\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u304c\u304a\u3053\u308b\u306e\u3067\u3053\u306e\u6cbb\u7642\u3092\u5acc\u3046\u5148\u751f\u3082\u3044\u307e\u3059\u3002\u307e\u305f\uff0c\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u30a2\u30ec\u30eb\u30ae\u30fc\u304c\u751f\u3058\u3066\u4f7f\u3048\u306a\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u9577\u671f\u9593\uff08\uff12\u5e74\u304f\u3089\u3044\uff09\u4f7f\u7528\u3067\u304d\u308b\u5316\u5b66\u7642\u6cd5\u3068\u3044\u3046\u306e\u304c\u3053\u306e\u6cbb\u7642\u6cd5\u306e\u5f37\u307f\u3067\u3082\u3042\u308b\u3067\u3057\u3087\u3046\u3002\u9006\u306b<span style=\"color: #000080;\"><strong>\uff14\u5272\u8fd1\u3044\u4f8b\u304c\u3053\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3067\u3042\u308b<\/strong><\/span>\u3053\u3068\u3082\u5fd8\u308c\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u4e73\u5e7c\u5150\u306e\u5927\u304d\u306a\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3078\u306e\u5c0e\u5165\u5316\u5b66\u7642\u6cd5\u3068\u3057\u3066\u306f\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3092\u4f7f\u3063\u305f\u65b9\u304c\u594f\u529f\u7387\u306f\u9ad8\u3044\u3067\u3059\u3002<\/p>\n<h4 class=\"setumei\"><strong>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\uff08\u30a8\u30af\u30b6\u30fc\u30eb\uff09<\/strong><\/h4>\n<p>\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u306e\u521d\u671f\u5316\u5b66\u7642\u6cd5\u306e\u7d99\u7d9a\u304c\u96e3\u3057\u304f\u306a\u3063\u305f\u6642\u306b\uff0c\u30bb\u30ab\u30f3\u30c9\u30e9\u30a4\u30f3\u3068\u3057\u3066\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3 (vinca alkaloid) \u304c\u5e83\u304f\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u9031\u306b1\u56de\u306e\u6ce8\u5c04 (6 mg\/m2, once per week, over a period of 70 weeks) \u3067\u4f7f\u3044\u307e\u3059\u3002\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306a\u306e\u3067\u9577\u671f\u6295\u4e0e\u304c\u53ef\u80fd\u3067\u3059\u3002\u594f\u529f\u5272\u5408\u306f\u4e0a\u8a18\u306e\u3082\u306e\u3088\u308a\u4f4e\u304f(<span style=\"color: #000080;\"><strong>minor reponse\u4ee5\u4e0a\u306726%\u7a0b\u5ea6<\/strong><\/span>)\uff0c\u5de8\u5927\u306a\u816b\u760d\u3092\u7e2e\u5c0f\u3055\u305b\u308b\u305f\u3081\u306e\u521d\u671f\u6cbb\u7642\u306b\u306f\u9069\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u5c0f\u3055\u306a\u816b\u760d\u306e\u521d\u671f\u6cbb\u7642\u3042\u308b\u3044\u306f\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u7528\u3044\u308b\u3079\u304d\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\uff08\u597d\u4e2d\u7403\u6e1b\u5c11\uff0c\u4e0a\u6c17\u9053\u611f\u67d3\uff0c\u767a\u71b1\uff09\u3092\u898b\u3066\uff0c5 mg\/m2\uff0c4 mg\/m2\u3078\u3068\u6e1b\u91cf\u3057\u306a\u304c\u3089\u9577\u671f\u6295\u4e0e\u3057\u307e\u3059\u3002<\/p>\n<h4 class=\"setumei\"><b>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/b><\/h4>\n<p class=\"setumei\">\u6708\u306b\uff15\u65e5\u9593\u3060\u3051\u81ea\u5b85\u3067\u98f2\u307f\u307e\u3059\u3002\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u306f\u3042\u308a\u307e\u3059\u304c\uff0c\u7dad\u6301\u7642\u6cd5\u3068\u3057\u3066\u4f7f\u3046\u3079\u304d\u85ac\u5264\u3067\u3059\u3002\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u306a\u306e\u3067\u5e74\u4f59\u306e\u6295\u4e0e\u3067\u306f2\u6b21\u764c\u306e\u5fc3\u914d\u304c\u5c11\u3057\u3042\u308a\uff0c\u6295\u4e0e\u306f\u9650\u3089\u308c\u305f\u671f\u9593\u306b\u8a2d\u5b9a\u3057\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002\u3067\u3082\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3060\u3051\u3067\u6cbb\u3063\u305f\u5b50\u3082\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>\u30a2\u30d0\u30b9\u30c1\u30f3\uff08\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff09<\/strong><\/h4>\n<p>\u5f37\u304f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u30bf\u30a4\u30d7\uff08\u591a\u304f\u306fpilomyxoid type)\u306b\u6709\u52b9\u3067\u3059\u3002\u816b\u760d\u3092\u5c0f\u3055\u304f\u3059\u308b\u52b9\u679c\u306f\u9ad8\u3044\u306e\u3067\u3059\u304c\uff0c\u6295\u4e0e\u3092\u4e2d\u65ad\u3059\u308b\u3068\u307e\u305f\u816b\u760d\u306f\u5897\u5927\u3057\u307e\u3059\u3002\u6025\u3044\u3067\u816b\u760d\u3092\u53d6\u308a\u3042\u3048\u305a\u5c0f\u3055\u304f\u304f\u3057\u3066\u8996\u529b\u3092\u52a9\u3051\u305f\u3044\u6642\u306b\u306f\u6709\u529b\u3067\u3059\u3002\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u307f\u30921\u56de10mg\/kg\uff08\u4f53\u91cd\uff09\u30922\u9031\u9593\u9593\u9694\u3067\u70b9\u6ef4\u9759\u8108\u5185\u6ce8\u5c04\u3057\u307e\u3059\u3002<\/p>\n<h4><strong>\u30a2\u30d5\u30a3\u30cb\u30c8\u30fc\u30eb\uff08\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\uff09<\/strong><\/h4>\n<p>\u9577\u671f\u9593\u7d4c\u53e3\u6295\u4e0e\u3067\u304d\u308b\u85ac\u5264\u3067\u3059\u3002\u7c73\u56fd\u3067\u81e8\u5e8a\u8a66\u9a13\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u304c\uff0c\u65e5\u672c\u3067\u306f\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u7528\u3067\u304d\u306a\u3044\u306e\u3067\u85ac\u5264\u8cbb\u304c\u9ad8\u984d\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<h4><b>\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6 v<\/b>emurafenib<\/h4>\n<p>BRAF\u963b\u5bb3\u5264\u3067\u3059\u3002BRAF-V600E\u306e\u5909\u7570\u304c\u3042\u308b\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\u6709\u52b9\u3067\u3059\u3002\u307e\u3060\u6cbb\u9a13\u306e\u6bb5\u968e\u30672023\u5e74\u6642\u70b9\u3067\u65e5\u672c\u306b\u306f\u5c0e\u5165\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h4><strong>\u30bb\u30eb\u30e1\u30c6\u30a3\u30cb\u30d6 s<span class=\"highlight\">elumetinib<\/span><\/strong><\/h4>\n<p>BRAF\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3042\u308b\u4f8b\u306b\u7d4c\u53e3\u6295\u4e0e\u3055\u308c\u307e\u3059\u3002MEK\u963b\u5bb3\u5264\u3067\u3059\u30022020\u5e74\u306e\u6bb5\u968e\u3067\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4><strong>\u30d3\u30ce\u30ec\u30eb\u30d3\u30f3\uff08\u30ca\u30d9\u30eb\u30d3\u30f3\uff09<\/strong><\/h4>\n<p>\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u7cfb\u85ac\u5264\u3067\uff0c\u5916\u6765\u3067\u6ce8\u5c04\u3057\u3066\u6bd4\u8f03\u7684\u9577\u671f\u306b\u4f7f\u7528\u3057\u307e\u3059\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4e4f\u3057\u3044\u306e\u3067\u3059\u304c\uff0c\u6587\u732e\u306f\u3042\u308a\u307e\u3059\u3002\u4fdd\u967a\u9069\u5fdc\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h3>\u624b\u8853\u6cbb\u7642\u306e\u5f79\u5272<\/h3>\n<p><span style=\"color: #000080;\"><strong>Sawamura Y<\/strong><\/span>, et al.: Role of Surgery for Optic pathway \/ Hypothalamic Astrocytomas in Children. Neuro Oncol 10: 725-733, 2008<\/p>\n<ul>\n<li>\u3053\u306e\u816b\u760d\u306f\u753b\u50cf\u8a3a\u65ad\u3067\u304d\u308b\u306e\u3067\uff0c\u75c5\u7406\u8a3a\u65ad\u306e\u305f\u3081\u306e\u751f\u691c\u624b\u8853\u306f\u5fc5\u8981\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\uff0c\u8996\u795e\u7d4c\uff0c\u8996\u4ea4\u53c9\uff0c\u8996\u7d22\u3068\u3044\u3046\u6458\u51fa\u3059\u308c\u3070\u969c\u5bb3\u304c\u3067\u308b\u90e8\u4f4d\u306b\u767a\u751f\u3057\u307e\u3059\u304b\u3089\uff0c\u624b\u8853\u3092\u3059\u308b\u304b\u3069\u3046\u304b\u306e\u5224\u65ad\u306f\u6975\u3081\u3066\u96e3\u3057\u3044\u3082\u306e\u3067\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u4e73\u5e7c\u5150\uff0c\u5c0f\u3055\u3044\u5b50\u4f9b\u306e\u6cbb\u7642\u306e\u57fa\u672c\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u3067\u3042\u3063\u3066\uff0c\u624b\u8853\u6cbb\u7642\u306f\u5316\u5b66\u7642\u6cd5\u3078\u306e\u88dc\u52a9\u6cbb\u7642\u3068\u306a\u308a\u307e\u3059\u3002<\/strong><\/span><\/li>\n<li>\u5c0f\u8133\u767a\u751f\u306e\u3082\u306e\u3068\u6b63\u53cd\u5bfe\u3067\uff0c\u5358\u795e\u7d4c\u816b\u760d single optic nerve glioma\u4ee5\u5916\u306f\uff0c\u5b8c\u5168\u6458\u51fa\u306f\u3067\u304d\u307e\u305b\u3093<\/li>\n<li>\u5fc5\u8981\u3067\u3042\u308c\u3070\u90e8\u5206\u6458\u51fa\u8853\u3092\u3057\u307e\u3059\u304c\uff0c\u305d\u306e\u6642\u671f\u3068\u624b\u8853\u306e\u65b9\u6cd5\u304c\u3068\u3066\u3082\u8907\u96d1\u3067\u96e3\u3057\u3044\u3067\u3059<\/li>\n<li>\u624b\u8853\u306f<span style=\"color: #000080;\"><strong>\u6e1b\u8377\u8853 debulking surgery<\/strong><\/span>\u3068\u3044\u3044\uff0c\u3067\u304d\u308b\u3060\u3051\u305f\u304f\u3055\u3093\u306e\u91cf\u3092\u6458\u51fa\u3057\u3066\u6642\u9593\u3092\u304b\u305b\u3050\u3068\u3044\u3046\u76ee\u7684\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u306a\u305c\u306a\u3089\u5e74\u9f62\u304c\u9ad8\u304f\u306a\u308b\u3068\u3053\u306e\u816b\u760d\u306f\u5927\u304d\u304f\u306a\u3089\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\uff0c\u305d\u3053\u307e\u3067\u306e\u6642\u9593\uff08\u5e74\u6708\uff09\u3092\u304b\u305b\u3050\u306e\u3067\u3059<\/li>\n<li>\u5e74\u9577\u5150\u304b\u3089\u601d\u6625\u671f\u306b\u306a\u3063\u3066\u816b\u760d\u304c\u306e\u3046\u80de\u6027\u62e1\u5927\u3057\u3066\u304d\u305f\u3068\u304d\u306b\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u3067\u306f\u7e2e\u5c0f\u3057\u306a\u304f\u306a\u308a\u307e\u3059\u304b\u3089\uff0c\u624b\u8853\u3067\u306e\u3046\u80de\u58c1\u3092\u542b\u3081\u3066\u90e8\u5206\u6458\u51fa\u3057\u307e\u3059<\/li>\n<li>\u6c34\u982d\u75c7\u306b\u5bfe\u3057\u3066\u306f\uff0c\u5185\u8996\u93e1\u306b\u3088\u308b\u900f\u660e\u4e2d\u9694\u7a7f\u7834\u3068V-P\u30b7\u30e3\u30f3\u30c8\u3092\u3057\u307e\u3059<\/li>\n<li>\u5e74\u9577\u5150\u304b\u3089\u6210\u4eba\u671f\u306b\u5165\u308a\uff0cMRI\u3067\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u816b\u760d\u304c\u5c0f\u3055\u304f\uff0c\u305d\u306e\u90e8\u5206\u3060\u3051\u6458\u51fa\u3059\u308c\u3070\u3082\u3046\u5897\u5927\u3057\u306a\u3044\u3068\u3044\u3046\u5224\u65ad\u304c\u3042\u308c\u3070\u6458\u51fa\u3057\u307e\u3059\uff0c\u3053\u308c\u306f\u6cbb\u7652\u3092\u76ee\u6307\u3057\u305f\u624b\u8853\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u5e74\u9577\u5150\u3084\u6210\u4eba\u3067\u306f\u624b\u8853\u6cbb\u7642\u306e\u5f79\u5272\u306f\u304b\u306a\u308a\u5927\u304d\u304f\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n<h3>\u653e\u5c04\u7dda\u6cbb\u7642<\/h3>\n<ul>\n<li>\u884c\u3046\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u5c0f\u3055\u3044\u5b50\u3069\u3082\u306e\u8996\u5e8a\u4e0b\u90e8\uff0c\u5927\u8133\u57fa\u5e95\u6838\uff0c\u8996\u795e\u7d4c\u3068\u8996\u4ea4\u5dee\u3001\u8996\u7d22\uff0c\u4e73\u982d\u4f53\uff0c\u4e0b\u5782\u4f53\u306a\u3069\u304c\u88ab\u7206\u3059\u308b\u304b\u3089\u3067\u3059<\/li>\n<li>\u3053\u306e\u9818\u57df\u306e\u7167\u5c04\u306f\uff0c<span style=\"color: #ff0000;\"><strong>midline cranial irradiation\u3068\u547c\u3070\u308c\u307e\u3059\u304c\uff0c\u5c0f\u3055\u306a\u5b50\u3069\u3082\u306b\u306f\u9045\u767a\u6027\u653e\u5c04\u7dda\u969c\u5bb3\u304c\u3068\u3066\u3082\u3072\u3069\u3044\u306e\u3067\u3059<\/strong><\/span><\/li>\n<li>\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\uff08\u9ad8\u6b21\u8133\u6a5f\u80fd\u969c\u5bb3\uff09\u304c\u907f\u3051\u3089\u308c\u305a\uff0c\u8996\u529b\u969c\u5bb3\u3068\u5b66\u7fd2\u969c\u5bb3\u3067\u81ea\u7acb\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n<h4>\u8996\u8def\u30fb\u8996\u5e8a\u4e0b\u90e8\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3067\u547d\u3092\u5931\u3063\u3066\u3057\u307e\u3046\u6642<\/h4>\n<ul>\n<li><span style=\"color: #333333;\">\u3053\u306e\u816b\u760d\u3067\u547d\u3092\u5931\u3046\u5b50\u4f9b\u3084\u82e5\u8005\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093<\/span><\/li>\n<li><span style=\"color: #333333;\">\u816b\u760d\u304c\u5de8\u5927\u306b\u306a\u308b\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\uff0c\u9ac4\u6db2\u5438\u53ce\u969c\u5bb3\u30fb\u96e3\u6cbb\u6027\u6c34\u982d\u75c7\uff0c\u8133\u30d8\u30eb\u30cb\u30a2\uff0c\u9ac4\u6db2\u64ad\u7a2e\uff0c\u96e3\u6cbb\u6027\u3066\u3093\u304b\u3093\u306a\u3069\u304c\u539f\u56e0\u3067\u6b7b\u4ea1\u3057\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u4e00\u756a\u306e\u539f\u56e0\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u3067\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u3063\u305f\u6642\u306b\uff0c<span style=\"color: #000080;\"><strong>\u7d4c\u904e\u89b3\u5bdf\u3092\u3057\u3059\u304e\u3066\u816b\u760d\u3092\u5de8\u5927\u5316\u3055\u305b\u3066\u3057\u307e\u3046<\/strong><\/span>\u3053\u3068\u306b\u3088\u308a\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u5927\u304d\u306a\u8003\u3048\u9055\u3044\u306f\uff0c\u601d\u6625\u671f\u306b\u306a\u308b\u3068\u816b\u760d\u306e\u5897\u5927\u50be\u5411\u304c\u6b62\u307e\u308b\uff08\u81ea\u7136\u9000\u7e2e\uff09\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u3068\uff0c\u671f\u5f85\u3057\u3059\u304e\u3066\u816b\u760d\u3092\u307b\u3063\u3066\u304a\u304f\u3053\u3068\u306b\u3042\u308a\u307e\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u6cbb\u7642\u6cd5\u306f\uff0c\u5316\u5b66\u7642\u6cd5\uff0c\u624b\u8853\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u816b\u760d\u304c\u5de8\u5927\u5316\u3057\u3066\u3057\u307e\u3046\u524d\u306b\uff0c\u624b\u6bb5\u3092\u5c3d\u304f\u3057\u3066\u6cbb\u7642\u3092\u7d99\u7d9a\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/span><\/li>\n<li>\u7279\u306b\uff0c\u624b\u8853\u3067\u306e\u6e1b\u8377\uff08\u4e9c\u5168\u6458\u51fa\uff09\u304c\u6709\u7528\u3067\u3059\uff0c\u3067\u3082\u96e3\u6613\u5ea6\u304c\u9ad8\u3044\u3067\u3059<\/li>\n<li><span style=\"color: #333333;\">100 cm2 (ml)\u306e\u816b\u760d\u4f53\u7a4d\u3092\u8d85\u3048\u306a\u3051\u308c\u3070\u3088\u3044\u306a\u3069\u3068\u5b89\u6613\u306a\u8003\u3048\u306f\u3082\u3063\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/span><\/li>\n<\/ul>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-9441\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/solaillust1-196x300.jpg\" alt=\"solaillust1\" width=\"196\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/solaillust1-196x300.jpg 196w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/solaillust1-392x600.jpg 392w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/solaillust1.jpg 745w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/><\/p>\n<h4>\u8996\u7d22\u306b\u9650\u5c40\u3059\u308b\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13337\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy3-300x281.jpg\" alt=\"\" width=\"300\" height=\"281\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy3-300x281.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy3-550x516.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy3.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13338\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy1-300x289.jpg\" alt=\"\" width=\"300\" height=\"289\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy1-300x289.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy1-550x530.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy1.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13339\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy4-300x295.jpg\" alt=\"\" width=\"300\" height=\"295\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy4-300x295.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy4-550x541.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilocyticastroyy4.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u5de6\u306e\u8996\u7d22\u306e\u5185\u90e8\u304b\u3089\u767a\u751f\u3057\u305f\u3082\u306e\u3067\uff0c\u3053\u308c\u3082\u5358\u795e\u7d4c\u30fb\u8996\u795e\u7d4c\u81a0\u816b\u3068\u540c\u69d8\u306b\u3088\u304f\u307f\u308b\u3082\u306e\u3067\u3059\u3002\u5de6\u306e\u753b\u50cf\u3067\u8996\u795e\u7d4c\u4ea4\u53c9\u304c\u5168\u304f\u4fb5\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304c\u308f\u304b\u308a\u307e\u3059\u3002<br \/>\n\u5358\u8996\u795e\u7d4c\u81a0\u816b\u306f\u5168\u6458\u51fa\u3067\u304d\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u30bf\u30a4\u30d7\u306f\u5916\u5074\u819d\u72b6\u4f53\u3078\u53ca\u3076\u306e\u3067\u5b8c\u5168\u6458\u51fa\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u90e8\u5206\u6458\u51fa\u3068\u5b9a\u4f4d\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u9069\u5fdc\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<hr \/>\n<h5>\u00a0\u6587\u732e\u60c5\u5831<\/h5>\n<h4><i>BRAF<\/i> V600 mutation\u306e\u3042\u308b\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u3068\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u304c\u6709\u52b9<\/h4>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Bouffet E:\u00a0<\/span>Dabrafenib plus Trametinib in Pediatric Glioma with <i>BRAF<\/i> V600 Mutations. N Engl J Med 2023<br \/>\n\u4e0b\u8a18\u306e\u5b66\u4f1a\u767a\u8868\u304c\u8ad6\u6587\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u5358\u72ec\u3042\u308b\u3044\u306f\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u3067\uff0c<i>BRAF<\/i> V600 mutation\u3092\u6709\u3059\u308b\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6709\u52b9\u306a\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\/\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068CBDCA\/VCR\u306e\u52b9\u679c\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002CBDCA\/VCR\u306f\u65e7\u6765\u5c0f\u5150\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6700\u3082\u4f7f\u7528\u3055\u308c\u305f\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u3067\u3059\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\/\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306744%\uff0cCBDCA\/VCR\u306711%\u306e\u594f\u529f\u7387 (CR or PR)\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u81e8\u5e8a\u7684\u306a\u5229\u70b9\u306f\u305d\u308c\u305e\u308c86%\u306846\uff05\u3067\u3057\u305f\u3002PFS\u4e2d\u592e\u5024\u306f20\u30f6\u6708\u30687.4\u30f6\u6708\u3067\u3057\u305f\u3002<br \/>\n\u300c\u4e00\u8a00\u300fPFS\u304c20\u30f6\u6708\u3068\u3044\u3046\u3053\u3068\u306f\uff0c2\u5e74\u3092\u5f85\u305f\u305a\u306b\u518d\u71c3\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3057\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3067\u306f\uff0c\u671f\u5f85\u3067\u3059\u304c\uff0c\u6570\u5e74\u306e\u6642\u9593\u7a3c\u304e\u304c\u3067\u304d\u3066\uff0c\u305d\u306e\u5185\u306b\u518d\u5897\u5927\u3057\u306a\u3044\u816b\u760d spontaneous involution \u3068\u306a\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3082\u3046\u4e00\u3064\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306eCBDCA\/VCR\u306e\u594f\u529f\u7387\u306f11%\u3067\u306f\u306a\u304f\u3066\uff0c50\uff05\u3092\u8d85\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u3067\u3059\u304b\u3089\uff0c\u3053\u306e\u6cbb\u9a13\u3067\u306fCBDCA\/VCR\u304c\u52b9\u304d\u3065\u3089\u3044\u816b\u760d\u7fa4\u304c\u5bfe\u8c61\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u306b\u6ce8\u610f\u3067\u3059\u3002<\/p>\n<h4><i>BRAF<\/i> V600 mutation\u306e\u3042\u308b\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u3068\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u304c\u3042\u308b\u7a0b\u5ea6\u6709\u52b9<\/h4>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Hargrave DR:\u00a0<\/span>Phase II Trial of Dabrafenib Plus Trametinib in Relapsed\/Refractory <i>BRAF<\/i> V600-Mutant Pediatric High-Grade Glioma. J Clin Oncol 2023<br \/>\n<i>BRAF<\/i> V600 mutation\u306f\u5c0f\u5150\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e8-10%\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u300241\u4f8b\u306e\u518d\u767a\u3042\u308b\u3044\u306f\u6cbb\u7642\u62b5\u6297\u6027\u306e\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u5bfe\u8c61\u3067\u3059\u3002\u594f\u529f\u5272\u5408\u306f56%\uff0c\u53cd\u5fdc\u671f\u9593\u4e2d\u592e\u5024\u306f22\u30f6\u6708\u3067\u3057\u305f\u3002\u534a\u5206\u304f\u3089\u3044\u306e\u4f8b\u30672\u5e74\u5f31\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\">\u96e3\u6cbb\u4f8b\u306f\uff0c\u767a\u75c7\u5e74\u9f62\u304c\u65e9\u304f\uff0c\u7537\u5150\u306b\u591a\u304f\uff0cBRAF\u878d\u5408\u304c\u3042\u308b<\/span><\/h4>\n<p class=\"heading-title\">Li X: The clinical and molecular characteristics of progressive hypothalamic\/optic pathway pilocytic astrocytoma. Neuro 0ncol 2023<br \/>\n\u8996\u5e8a\u4e0b\u90e8\u8996\u8def\u3092\u4fb5\u3059\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\u57fa\u672c\u7684\u306b\u306f\u96e3\u6cbb\u6027\u75be\u60a3\u3067\uff0c\u521d\u671f\u6cbb\u7642\u306b\u6297\u3057\u3066\u9032\u884c\u3057\u305f\u308a\uff0c\u64ad\u7a2e\u3057\u305f\u308a\uff0c\u816b\u760d\u6b7b\u306b\u81f3\u308b\u4f8b\u304c\u3042\u308a\u307e\u3059\u300272\u4f8b\u304c\u5206\u6790\u3055\u308c\u307e\u3057\u305f\uff0c\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f12.3\u5e74\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a<span style=\"color: #000080;\"><strong>\u96e3\u6cbb\u4f8b\u306e\u7279\u5fb4\u306f\uff0c\u7537\u5973\u6bd4\u304c 2.6 : 1\uff0c\u8a3a\u65ad\u5e74\u9f62\u304c\u82e5\u304f3.2\u6b73\uff0c\u4e88\u5f8c\u826f\u597d\u4f8b\u3068\u6bd4\u8f03\u3057\u3066\uff0cKIAA1549-BRAF fusion\u304c\u975e\u5e38\u306b\u9ad8\u3044<\/strong><\/span> (81.5% vs 38.5%, P =.0032)\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<h4>NF-1 \u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306b\u3067\u304d\u308b\u96e3\u6cbb\u6027\u306e\u3082\u306e<\/h4>\n<p>Notch C: Risk Factors for Treatment Refractory and Relapsed Optic Pathway Glioma in Children with Neurofibromatosis Type 1. Neuro Oncol, 2022<br \/>\nNF-1\u306e\u5b50\u4f9b\u306b\u767a\u751f\u3059\u308b\u8996\u795e\u7d4c\u81a0\u816b\u306f\u6cbb\u7642\u306e\u5fc5\u8981\u306e\u306a\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u65b9\u3067\u4e88\u5f8c\u306e\u60aa\u3044\u6cbb\u7642\u62b5\u6297\u6027\u306e\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u4f8b\u30673\u5206\u306e\uff11\u3067\u5316\u5b66\u7642\u6cd5\u304c\u52b9\u304b\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002103\u4f8b\u3067\u5316\u5b66\u7642\u6cd5\u5f8c\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f95\u30ab\u6708\u3067\u3059\u300282%\u306e\u60a3\u5150\u304c\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3092\u57fa\u5264\u3068\u3057\u305f\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u3002<span style=\"color: #000080;\"><strong>45\u4f8b (44%)\u304c\u521d\u671f\u5316\u5b66\u7642\u6cd5\u62b5\u6297\u6027<\/strong><\/span>\u3067\u3057\u305f\u300224\u30f6\u6708\u672a\u6e80\u306e\u5b50\u4f9b\u304b\u3064\u8996\u795e\u7d4c\u3088\u308a\u5f8c\u65b9\u3078\u9032\u5c55\u3057\u305f\u4f8b\u3067\u5316\u5b66\u7642\u6cd5\u62b5\u6297\u6027\u306e\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u5f53\u305f\u308a\u524d\u306e\u3053\u3068\u3067\u3059\u304c\uff0c\u8996\u795e\u7d4c\u4e73\u982d\u306e\u7570\u5e38\u6240\u898b\uff0c\u9ad8\u5ea6\u306e\u8996\u529b\u969c\u5bb3\u3067\u767a\u75c7\u3057\u305f\u4f8b\u3067\u4e88\u5f8c\u304c\u60aa\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>\u8996\u4ea4\u53c9\u524d\u65b9\u306e\u8996\u795e\u7d4c\u3092\u4fb5\u3059\u306e\u307f\u306e\u8996\u795e\u7d4c\u816b\u760d\u306e\u6458\u51fa\u8853<\/h4>\n<p>Zipfel J: Surgical Management of Pre-Chiasmatic Intraorbital Optic\u00a0Nerve Gliomas in Children after Loss of Visual\u00a0Function\u2014Resection from Bulbus to Chiasm. Children 2022<br \/>\n\u773c\u7aa9\u306e\u306a\u304b\u306b\u3042\u3063\u3066\uff0c\u76ee\u304c\u3068\u3066\u3082\u75db\u304b\u3063\u305f\u308a\uff0c\u76ee\u304c\u816b\u760d\u306b\u62bc\u3055\u308c\u3066\u98db\u3073\u51fa\u3057\u3066\u304f\u308b\u3068\u304d\u306b\uff0c\u816b\u760d\u3092\u624b\u8853\u3067\u4e9c\u5168\u6458\u51fa\u3057\u307e\u3059\u3002\u305d\u306e\u65b9\u6cd5\u304c\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u809d\u5fc3\u306a\u306e\u306f\uff0c\u773c\u7403\u6e29\u5b58\u3068\u773c\u7403\u904b\u52d5\u306e\u6e29\u5b58\u3067\u3059\u3002\u52d5\u773c\u795e\u7d4c\u6a5f\u80fd\u3092\u4fdd\u3061\u306a\u304c\u3089\u816b\u760d\u3092\u4e9c\u5168\u6458\u51fa\u3059\u308b\u3068\u6cbb\u308a\u307e\u3059\u3002<\/p>\n<h4>\u8996\u4ea4\u53c9\u524d\u65b9\u306e\u8996\u795e\u7d4c\u3092\u4fb5\u3059\u306e\u307f\u306e\u8996\u795e\u7d4c\u816b\u760d\u306e\u6458\u51fa\u8853<\/h4>\n<p>\u6fa4\u6751\u3000\u8c4a\uff1a\u8996\u8def \u30fb \u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u624b\u8853\uff0c\u767a\u751f\u90e8\u4f4d\/\u624b\u8853\u9069\u5fdc\u3092\u6c7a\u3081\u308b\u305f\u3081\u306e\u5927\u307e\u304b\u306a\u5206\u985e\/\u624b\u8853\u9069\u5fdc\/\u5358\u8996\u795e\u7d4c\u816b\u760d\u306e\u9451\u5225\/\u624b\u8853\u306e\u76ee\u7684\/\u773c\u7aa9\u5185\u5358\u8996\u795e\u7d4c\u81a0\u816b\u306e\u624b\u8853\u624b\u6280\/\u518d\u767a\u6642\u306e\u6cbb\u7642\u65b9\u6cd5\u3002\u30b0\u30ea\u30aa\u30fc\u30de\uff0c\u30d7\u30e9\u30a4\u30e0\u8133\u795e\u7d4c\u5916\u79d14\uff0c\u9688\u90e8\u4fca\u5b8f\u7de8\u96c6<br \/>\n\u773c\u7aa9\u5185\u6bdb\u69d8\u7d30\u80de\u661f\u7d30\u80de\u816b\u306e\u6458\u51fa\u65b9\u6cd5\u304c\u753b\u50cf\u3092\u5165\u308c\u3066\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u79c1\u304c\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n<h4>\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u6709\u52b9\u3067\u3042\u3063\u305f<\/h4>\n<p class=\"heading-title\">Mustansir F: Dabrafenib in BRAFV600E mutant pilocytic astrocytoma in a pediatric patient. Childs Nerv Syst 2020<br \/>\n\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e1\u4f8b\u306b\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u6709\u52b9\u3067\u3042\u3063\u305f1\u4f8b\u5831\u544a\u3067\u3059\u3002<\/p>\n<h4>BRAF\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\u30bb\u30eb\u30e1\u30c6\u30a3\u30cb\u30d6 s<span class=\"highlight\">elumetinib<\/span>\u304c\u6709\u52b9\u3060\u3063\u305f<\/h4>\n<p>Fangusaro J:\u00a0<span class=\"highlight\">Selumetinib<\/span> in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade <span class=\"highlight\">glioma<\/span>: a multicentre, phase 2 trial.\u00a0<span role=\"menubar\">Lancet Oncol.<\/span> 2019<br \/>\nBRAF aberrations (KIAA1549-BRAF fusion or the BRAF<sup>V600E\u00a0<\/sup>mutation)\u304c\u3042\u308a\u5f93\u6765\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\uff0cMEK\u963b\u5bb3\u5264\u3067\u3042\u308b<span class=\"highlight\">selumetinib\u304c\u7d4c\u53e3\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u300225\u4f8b\u4e2d9\u4f8b 36%\u3067sustained partial response\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u300211\u4f8b\u30673\u5e74\u307b\u3069\u5897\u60aa\u304c\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<h4>V600E\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u6709\u52b9\u3060\u3063\u305f<\/h4>\n<p>Kaley T: BRAF Inhibition in BRAF<sup>V600<\/sup>-Mutant Gliomas: Results From the VE-BASKET Study.J Clin Oncol.\u00a02018<br \/>\nUpadhyaya SA: Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases.\u00a0<span lang=\"EN-US\">Childs Nerv Syst.\u00a02018<br \/>\n\u3053\u306e2\u3064\u306e\u8ad6\u6587\u306f\uff0cBRAF-V600E\u5909\u7570\u306e\u3042\u3063\u305f\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\uff0cBRAF\u963b\u5bb3\u5264 \u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u304c\u6709\u52b9\u3067\u3042\u3063\u305f\u3053\u3068\u3092\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u306f\u521d\u671f\u6cbb\u7642\u3068\u3057\u3066\u3082\u7528\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/h4>\n<p>Lassaletta A, et al.: Phase II Weekly Vinblastine for Chemotherapy-Na\u00efve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study. J Clin Oncol. 2016<br \/>\n\u30c8\u30ed\u30f3\u30c8\u5b50\u3069\u3082\u75c5\u9662\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f\u3053\u3068\u306e\u306a\u304454\u4eba\u306elow-grade glioma\uff08\u5e74\u9f62\u4e2d\u592e\u50248\u6b73\uff09\u306b\u7528\u3044\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u518555\uff05\u304c\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3067\u3059\u3002minor response\u4ee5\u4e0a\u306e\u594f\u529f\u5272\u5408\u306f25.9%\u3067\uff0c\u816b\u760d\u306e\u9032\u884c\u5897\u5927\u3092\u6b62\u3081\u308bdisease stabilization\u306f87%\u3067\u3057\u305f\u3002\u8996\u529b\u304c\u60aa\u3044\u5b50\u4f9b\u306e20%\u3067\u8996\u529b\u6539\u5584\u304c\u3042\u308a\u307e\u3057\u305f\u30025\u5e74PFS\u306f53%\u3067\uff0c<em>BRAF <\/em>mutation\u3068\u4e88\u5f8c\u306e\u95a2\u4fc2\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u30024\u5206\u306e1\u306e\u5b50\u4f9b\u304c6mg\/m2, once per week\u00a0\u306770\u9031\u9593\u306e\u6cbb\u7642\u3092\u5b8c\u9042\u3067\u304d\uff0c\u6b8b\u308a\u306e\u5b50\u306f5mg\/m2\uff0c4mg\/m2\u3078\u3068\u6e1b\u91cf\u304c\u5fc5\u8981\u3067\u3057\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u306f\uff0c\u597d\u4e2d\u7403\u6e1b\u5c11(75.9%)\uff0c\u4e0a\u6c17\u9053\u611f\u67d3 (52%)\uff0c\u767a\u71b1(43%)\u3067\u3059\u300226\u9031(\u534a\u5e74\uff09\u6295\u4e0e\u307e\u3067\u306fQOL\u306e\u4f4e\u4e0b\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4 class=\"cit\">\u30d3\u30ce\u30ec\u30eb\u30d3\u30f3 VNR \u306e\u5358\u5264\u52b9\u679c<\/h4>\n<p>Cappellano AM: Single agent <span class=\"highlight\">vinorelbine<\/span> in pediatric patients with progressive optic pathway <span class=\"highlight\">glioma<\/span>. <span role=\"menubar\">J Neurooncol.<\/span> 2015<br \/>\n\u30d3\u30f3\u30ab\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u7cfb\u85ac\u5264\u3067\u3059\u3002optic pathway glioma\u306e23\u4eba\uff08\u5e73\u5747\u5e74\u9f6269\u30f6\u6708\uff09\u306b\uff0c<span class=\"highlight\">vinorelbine<\/span> (30 mg\/m(2) days 0, 8, 22) for a total of 18 cycles \u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u6709\u52b9\u6027 ovarall objective response \u306f63%\u3067\u3057\u305f\u3002grade III\/IV\u306e\u9aa8\u9ac4\u6291\u5236\u304c4\u4eba\u306b\u751f\u3058\u307e\u3057\u305f\u30027\u4eba\u3067\u6d88\u5316\u5668\u75c7\u72b6\uff0c1\u4eba\u3067\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u4e2d\u592e\u502433\u30f6\u6708\uff0c5\u5e74PFS\u306f37%\u3067\u3057\u305f\u3002<\/p>\n<h4>\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff08\u30a2\u30d0\u30b9\u30c1\u30f3\uff09\u3067\u8996\u529b\u8996\u91ce\u304c\u56de\u5fa9\u3059\u308b<\/h4>\n<p align=\"left\">Avery RA, et al.: Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab. JAMA Ophthalmol 132:111-114, 2014<br \/>\nPacker\u5148\u751f\u306e\u65bd\u8a2d\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306e\u5b50\u3069\u30822\u4eba\u3068\u5b64\u767a\u60272\u4eba\u306e\u5b50\u3069\u3082\u304c\uff0c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306e\u6295\u4e0e\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u5b50\u305f\u3061\u306f\u3059\u3067\u306b\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u3066\u9032\u884c\u6027\u306e\u8996\u529b\u306e\u60aa\u5316\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u30024\u4eba\u5168\u54e1\u3067<span style=\"color: #000080;\"><strong>\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306e\u6295\u4e0e\u4e2d\u306b\u304b\u306a\u308a\u306e\u8996\u529b\u3042\u308b\u3044\u306f\u8996\u91ce\u306e\u6539\u5584<\/strong><\/span>\u304c\u5f97\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u901a\u5e38\u306e\u5316\u5b66\u7642\u6cd5\u306b\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u3092\u4f75\u7528\u3059\u308c\u3070\u8996\u529b\u306e\u6539\u5584\u304c\u5f97\u3089\u308c\u308b\u3068\u306e\u610f\u898b\u3067\u3059\u3002<\/p>\n<h4>\u4f4e\u7528\u91cf\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30a8\u30c8\u30dd\u30b7\u30c9\u306e\u52b9\u679c\u306f\u9ad8\u3044<\/h4>\n<p>Cardellicchio S, et al.: Low-dose cisplatin-etoposide regimen for patients with optic pathway glioma: a report of four cases and literature review. Neuropediatrics 45: 42-49, 2014<br \/>\n\uff14\u4f8b\u3060\u3051\u306e\u5831\u544a\u3067\u3059\u304c\uff0c4\u4eba\u5168\u54e1\u3067<strong><span style=\"color: #000080;\">\u8996\u6a5f\u80fd\u306e\u56de\u5fa9<\/span><\/strong>\u304c\u3042\u308a\u816b\u760d\u306e\u9032\u884c\u304c\u6b62\u307e\u3063\u305f\u307e\u307e\u306b\u306a\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>\u624b\u8853\u6cbb\u7642\u306e\u5f79\u5272<\/h4>\n<p align=\"left\">Goodden J, et al: The role of surgery in optic pathway\/hypothalamic gliomas in children.\u3000 J Neurosurg Pediatr 13:1-12, 2014<br \/>\n1998\u5e74\u304b\u30892011\u5e74\u307e\u3067\u306e13\u5e74\u9593\u306bDr. Gooden\u304c42\u4eba\u306eoptic pathway glioma\u306e\u5b50\u3069\u3082\u3092\u6cbb\u7642\u3057\u305f\u7d4c\u9a13\u304c\u8a18\u8ff0\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5e74\u9f62\u4e2d\u592e\u5024\u304c5.7\u6b73\u3067\uff0c\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306e\u60a3\u5150\u304c19\u4eba\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u8ffd\u8de1\u671f\u9593\u306f77\u30f6\u6708\u3067\uff0c<strong><span style=\"color: #000080;\">11\u4eba\u304c\u6c34\u982d\u75c7\u306b\u5bfe\u3059\u308b\u30b7\u30e3\u30f3\u30c8\u624b\u8853<\/span><\/strong>\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u300221\u4eba\u306e\u60a3\u5150\u306722\u56de\u306e\u6e1b\u8377\u8853 debulking surgery\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u300210\u4eba\u304c\u521d\u56de\u6e1b\u8377\u624b\u8853\u306e\u307f\u3067\u3042\u3068\u306f\u7d4c\u904e\u89b3\u5bdf\u3068\u306a\u308a\u307e\u3057\u305f\u30024\u4eba\u304c\u6e1b\u8377\u8853\u3068\u305d\u306e\u5f8c\u306e\u5316\u5b66\u7642\u6cd5\u3067\u3057\u305f\u30027\u4eba\u306f\u3055\u307e\u3056\u307e\u306a\u6cbb\u7642\u304c\u306a\u3055\u308c\u305f\u5f8c\u3067\u6e1b\u8377\u8853\u304c\u5fc5\u8981\u3068\u306a\u3063\u305f\u3082\u306e\u3067\u3059\u3002\u6700\u7d42\u7684\u306b3\u4eba\u304c\u6b7b\u4ea1\u3057\u3066\u3044\u307e\u3059\u304c\uff0c\u539f\u56e0\u306f\u816b\u760d\u5897\u60aa\uff0c\u751f\u691c\u6642\u306e\u611f\u67d3\uff0c\u816b\u760d\u51fa\u8840\u3067\u3057\u305f\u3002<strong><span style=\"color: #000080;\">\u9577\u671f\u4e88\u5f8c\u304c\u3088\u3044\u306e\u3067\uff0c\u5316\u5b66\u7642\u6cd5\u3084\u624b\u8853\u3067\u6cbb\u7642\u3059\u308b\u3079\u304d\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642 midline cranial irradiation\u306f\u884c\u3046\u3079\u304d\u3067\u306f\u306a\u3044<\/span><\/strong>\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300dprimary\u00a0surgical\u00a0debulking of tumor (without adjuvant therapy) is safe and effective\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u7d0d\u5f97\u3067\u304d\u307e\u305b\u3093\u3002\u624b\u8853\u81ea\u4f53\u306e\u96e3\u6613\u5ea6\u304c\u9ad8\u3044\u3057\uff0c\u4e73\u5e7c\u5150\u3067\u306f\u624b\u8853\u3057\u3066\u3082\u6b8b\u3063\u305f\u816b\u760d\u304c\u3059\u3050\u306b\u5927\u304d\u304f\u306a\u3063\u3066\u3057\u307e\u3063\u3066\uff0c\u3044\u305a\u308c\u306b\u305b\u3088\u5316\u5b66\u7642\u6cd5\u304c\u5fc5\u7528\u3068\u306a\u308b\u304b\u3089\u3067\u3059\u3002\u6e1b\u8377\u624b\u8853\u306f\u6700\u5f8c\u306e\u624b\u6bb5\u3067\u3057\u3087\u3046\u3002 \u3053\u306e\u4e2d\u306e\u534a\u6570\u304f\u3089\u3044\u304c\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306e\u60a3\u5150\u3067\u4e88\u5f8c\u304c\u3088\u304b\u3063\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u305d\u308c\u306f\u5f53\u305f\u308a\u524d\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u3068\u305d\u3046\u3067\u306a\u3044\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\uff0c\u5206\u3051\u3066\u5206\u6790\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4 align=\"left\"><strong>\u30a2\u30d0\u30b9\u30c1\u30f3<\/strong>\u304c\u518d\u767a\u4f8b\u306b\u6709\u52b9\u3067\u3042\u308b<\/h4>\n<p align=\"left\">Hwang EI, et al.: Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatr Blood Cancer 60: 776-782, 2013<br \/>\n\u3053\u306e\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u304clow-grade glioma\u306a\u306e\u3067\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u3053\u3068\u3067\u306f\u306a\u3044\u3068\u601d\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u304c\uff0c\u307b\u3068\u3093\u3069\u306e\u4f8b\u304c\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u75c7\u4f8b\u306e\u8ad6\u6587\u3067\u3059\u3002\u00a0\u521d\u671f\u6cbb\u7642\uff08\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff0c\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff09\u304c\u3046\u307e\u304f\u884c\u304b\u305a\u306b\u518d\u71c3\u3057\u305f14\u4eba\u306e\u5b50\u3069\u3082\u304c\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u30026\u4eba\u3067\u306f\u64ad\u7a2e\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u5e74\u9f62\u4e2d\u592e\u5024\u306f5\u6b73\uff0c\u30a2\u30d0\u30b9\u30c1\u30f3\u3068\u30a4\u30ea\u30ce\u30c6\u30ab\u30f3\u306e\u4f75\u7528\u6295\u4e0e\u304c\u4e3b\u305f\u308b\u6cbb\u7642\u3067\u3042\u308a\uff0c\u6cbb\u7642\u671f\u9593\u4e2d\u592e\u5024\u306f12\u30f6\u6708\u3067\u3057\u305f\u300212\u4f8b\u3067\u816b\u760d\u7e2e\u5c0f\u304c\u3042\u308a\uff0c\u6700\u5c0f\u306b\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u308b\u307e\u3067\u306e\u671f\u9593\u306f9\u9031\u9593 (7-17\u9031) \u3068\u3044\u3046\u77ed\u3044\u671f\u9593\u3067\u3057\u305f\u3002<span style=\"color: #000080;\"><strong>\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u6295\u4e0e\u3092\u4e2d\u65ad\u3057\u305f\u308914\u4eba\u4e2d13\u4eba(93%)\u3067\u816b\u760d\u306e\u518d\u5897\u5927<\/strong><\/span>\u304c\u751f\u3058\u307e\u3057\u305f\u3002\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u307f\u30921\u56de10mg\/kg\uff08\u4f53\u91cd\uff09\u30922\u9031\u9593\u9593\u9694\u3067\u70b9\u6ef4\u9759\u8108\u5185\u6ce8\u5c04\u3059\u308b\u304b\uff0c\u4f75\u7528\u3059\u308b\u6642\u306f\u30a4\u30ea\u30ce\u30c6\u30ab\u30f3 125 mg\/m2\uff08\u4f53\u8868\u9762\u7a4d\uff09\u3092\u540c\u3058\u304f2\u9031\u9593\u9694\u3067\u6295\u4e0e\u3057\u307e\u3059\u3002\u521d\u671f\u6cbb\u7642\u3068\u3057\u306612\u30f6\u6708\u307b\u3069\u3092\u6295\u4e0e\u671f\u9593\u76ee\u6a19\u3068\u3057\u307e\u3059\u3002<\/p>\n<h4 align=\"left\">\u601d\u6625\u671f\u306b\u304a\u3051\u308b\u6cbb\u7642<\/h4>\n<p align=\"left\">Chong AL, et al.: Optic pathway gliomas in adolescence&#8211;time to challenge treatment choices? Neuro Oncol 15: 391-400, 2013<br \/>\n10\u6b73\u4ee5\u4e0a33\u4eba\u306e\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u8ffd\u8de1\u8abf\u67fb\u3067\u3059\u300282%\u3067\u8996\u899a\u969c\u5bb3\u304c\u3042\u308a\u307e\u3057\u305f\u30028\u4eba (24%) \u304c\u7d4c\u904e\u89b3\u5bdf\u306e\u307f\u3067\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u300225\u4eba\u3067\u521d\u56de\u6cbb\u7642\u304c\u306a\u3055\u308c\uff0c\u518d\u6cbb\u7642\u306f\u305d\u306e\u5185\u306e9\u4f8b (36%)\u3067\u5fc5\u8981\u3067\u3057\u305f\u3002\u521d\u56de\u6cbb\u7642\u5f8c\u306ePFS\u306f47\u30f6\u6708\u3067\u3057\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\uff0c\u5316\u5b66\u7642\u6cd5\u306f10\u6b73\u4ee5\u4e0a\u306e\u601d\u6625\u671f\u306e\u60a3\u5150\u306b\u304a\u3044\u3066\u3082\u6709\u52b9\u3067\u3042\u308b\u306e\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3088\u308a\u512a\u5148\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4 align=\"left\"><strong>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u306e\u52b9\u679c<\/strong><\/h4>\n<p>Bouffet E, et al.: Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma. J Clin Oncol 30: 1358-1363, 2012<br \/>\n\u624b\u8853\uff0c\u5316\u5b66\u7642\u6cd5\uff0c\u653e\u5c04\u7dda\u3067\u6cbb\u7642\u304c\u96e3\u3057\u304b\u3063\u305f\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\uff08\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3092\u542b\u3080\uff09\u306e\u5b50\u3069\u3082\u306b\uff0c<strong><span style=\"color: #000080;\">\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3 6mg\/m2\/week\u30921\u5e74\u9593\u4f7f\u7528<\/span><\/strong>\u3057\u307e\u3057\u305f\u300251\u4eba\u306e\u5b50\u3069\u3082\u304c\u767b\u9332\u3055\u308c\u305f\u81e8\u5e8a\u7b2c\uff12\u76f8\u8a66\u9a13\u3067\u3059\u3002\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u305f\u306e\u306f18\u4eba (36% including CR, PR, and MR)\u3067\u3057\u305f\u3002\u7d4c\u904e\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502467\u30f6\u6708\u306723\u4eba\u304c\u816b\u760d\u9032\u884c progression\u306a\u3057\u306b\u7d4c\u904e\u3057\u307e\u3057\u305f\u3002\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u306e\u816b\u760d\u7e2e\u5c0f\u3068\u3044\u3046\u610f\u5473\u3067\u306e\u594f\u529f\u5272\u5408\u306f\uff13\u5272\u7a0b\u5ea6\u3068\u307f\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3<\/h4>\n<p><span style=\"color: #000000;\">Sawamura Y,\u00a0et al.: Chemotherapy with cisplatin and vincristine for optic pathway\/hypothalamic astrocytoma in young children. Jpn J Clin Oncol\u00a039: 277-283, 2009<br \/>\n<\/span><span style=\"color: #000080;\"><strong>16\u4f8b\u306e\u4e73\u5e7c\u5150\u306e\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3092\u4f7f\u7528\u3059\u308b\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u305f\u6210\u7e3e\u3067\u3059\u3002CR, PR, MR\u3092\u8db3\u3059\u306812\u4f8b\u3067\u3057\u305f\u300275%\u3067\u306f\u3063\u304d\u308a\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u3063\u305f\u3068\u8a00\u3048\u307e\u3059\u3002<\/strong><\/span>disease stabilization\uff08\u75c5\u5909\u306e\u9032\u884c\u3092\u6b62\u3081\u308b\uff09\u3068\u3044\u3046\u610f\u5473\u3067\u306f100%\u306e\u6709\u52b9\u7387\u3067\u3059\u3002 \u6709\u540d\u306aPacker\u5148\u751f\u304c\u66f8\u3044\u305f\u3044\u308d\u3093\u306a\u8ad6\u6587\u3067\u306e\u826f\u3044\u6210\u7e3e\u3092\u53d6\u3063\u3066PR\u3068MR\u306f55\u4f8b\u4e2d\u306e33\u4f8b (60%)\u3067\u3059\u304b\u3089\uff0c\u305d\u306e\u6210\u7e3e\u3088\u308a\u306f\u52dd\u3063\u3066\u3044\u307e\u3059\u3002Massimo\u306f\uff0c\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30a8\u30c8\u30dd\u30b7\u30c9\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u4f7f\u3063\u3066\uff0c34\u4f8b\u4e2d\u306e24\u4f8b (71%) \u304cPR\/MR\u3067\u3042\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002 \u3067\u3082\u3053\u306e\u8ad6\u6587\u9593\u306e\u6bd4\u8f03\u306f\u614e\u91cd\u306b\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u79c1\u306e\u6210\u7e3e\u306b\u306f\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\uff11\u578b(NF-1)\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3057\uff0c\u8996\u795e\u7d4c\u4ea4\u53c9\u304b\u3089\u8996\u5e8a\u4e0b\u90e8\u3092\u4fb5\u3059\u5927\u304d\u306a\u4e73\u5e7c\u5150\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3060\u3051\u3092\u6cbb\u7642\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u672c\u6765\u306f\u53b3\u3057\u3044\u4e88\u5f8c\u306e\u306f\u305a\u3067\u3059\u3002\u307e\u305f\uff0cPacker\u3084Massimo\u306e\u8ad6\u6587\u306e\u5bfe\u8c61\u306fNF-1\u3084\u4ed6\u306e\u90e8\u4f4d\u306e\u661f\u7d30\u80de\u816b\u3084\u5e74\u9577\u5150\u3092\u542b\u307f\u307e\u3059\u3002<\/p>\n<h4>\u8996\u795e\u7d4c\uff08\u8996\u8def\uff09\u306b\u767a\u751f\u3057\u305f\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\u5bfe\u3059\u308b<strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u52b9\u679c<\/strong><\/h4>\n<p>Gururangan S et al. Temozolomide in children with progressive low-grade glioma. Neuro-oncol 9: 161-168, 2007<br \/>\n\u3053\u306e\u8ad6\u6587\u306f\uff0c\u60aa\u6027\u5ea6\u306e\u4f4e\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u3082\u3064\u306e30\u4eba\u306e\u5b50\u4f9b\u305f\u3061\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u3063\u305f\u7d4c\u9a13\u3092\u66f8\u3044\u3066\u3044\u307e\u3059\u3002\u5e73\u5747\u5e74\u4ee410\u6b73\u3067\u3044\u305a\u308c\u3082\u75c5\u72b6\u304c\u9032\u884c\u6027\u306e\u5b50\u4f9b\u305f\u3061\u3067\u3059\u3002\u3053\u306e\u4e2d\u306e26\u4eba\u306f\u8996\u795e\u7d4c\u306b\u3067\u304d\u305f\u816b\u760d\u3067\u3042\u308b\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u5b50\u4f9b\u3067\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f200mg\/m2\u3092\uff15\u65e5\u9593\u4f7f\u3046\u666e\u901a\u306e\u65b9\u6cd5\u3067\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u300226\u4eba\u306e\u5185\u306e\uff13\u4eba\u3067\u816b\u760d\u304c\u534a\u5206\u304f\u3089\u3044\u306b\u306a\u308a(PR)\uff0c\uff11\u4eba\u3067\u816b\u760d\u304c\u307b\u3093\u306e\u5c11\u3057\u5c0f\u3055\u304f\u306a\u308a(MR)\uff0c10\u4eba\u3067\u540c\u3058\u3067\u5909\u308f\u3089\u305a(SD)\uff0c12\u4eba\u3067\u6295\u4e0e\u4e2d\u306b\u5927\u304d\u304f\u306a\u308a\u307e\u3057\u305f(PD)\u3002<strong><span style=\"color: #000080;\">54%\u306e\u5b50\u4f9b\u3067\u75c5\u72b6\u306e\u9032\u884c\u304c\u4e00\u6642\u7684\u306b\u3082\u6b62\u307e\u308a\uff0c34\u30f6\u6708\u304f\u3089\u3044\u7dad\u6301\u3067\u304d\u305f\u3068\u306e\u3053\u3068\u3067\u3059<\/span><\/strong>\u3002\u526f\u4f5c\u7528\u306f\u8efd\u5ea6\u306e\u3082\u306e\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u3044\u308d\u3044\u308d\u306a\u6cbb\u7642\u306e\u5f8c\u3067\u30c6\u30e2\u30c0\u30fc\u30eb\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u306e\u3067\uff0c\u3042\u308b\u7a0b\u5ea6\u306e\u52b9\u679c\u306f\u3042\u308b\u3068\u5224\u65ad\u3067\u304d\u308b\u6210\u7e3e\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\uff0c\u816b\u760d\u306e\u7e2e\u5c0f\u306f26\u4eba\u4e2d\u3067\uff14\u4eba\u306b\u898b\u3089\u308c\u305f\u3060\u3051\u3067\u3059\u3057\uff0c\u304a\u305d\u3089\u304f\u5f93\u6765\u306e\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3084\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3092\u4f7f\u3046\u5316\u5b66\u7642\u6cd5\u306b\u306f\u52a3\u308a\u307e\u3059\u3002\u5f93\u3063\u3066\uff0c\u305d\u308c\u3089\u306e\u85ac\u304c\u4f7f\u3048\u306a\u304f\u306a\u3063\u305f\u6642\u306e\uff13\u756a\u76ee\u304f\u3089\u3044\u306e\u5316\u5b66\u7642\u6cd5\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u3068\u8003\u3048\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4>\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3078\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u3082\u3063\u305f\u5b50\u4f9b\u306e\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3078\u306e<strong>\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u5358\u72ec\u5316\u5b66\u7642\u6cd5<\/strong>\u306e\u52b9\u679c<\/h4>\n<p>Lafay-Cousin L, et al. Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer 103: 2636-2642, 2005<br \/>\n\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3092\u542b\u3080\u60aa\u6027\u5ea6\u306e\u4f4e\u3044\u795e\u7d4c\u81a0\u816b\uff08\u30b0\u30ea\u30aa\u30fc\u30de\uff09\u3078\u306e\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\uff08\u30a8\u30af\u30b6\u30fc\u30eb\uff09\u306e\u5358\u72ec\u52b9\u679c\u3092\u898b\u305f\u3082\u306e\u3067\u3059\u3002\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3068\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u306e\u5316\u5b66\u7642\u6cd5\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u305f\u3081\u306b\u4f7f\u3048\u306a\u304f\u306a\u3063\u305f\uff19\u4eba\u306e\u5b50\u4f9b\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u9031\u306b\uff11\u56de\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u3092\u6295\u4e0e\u3059\u308b\u65b9\u6cd5\u3067\uff0c\u5916\u6765\u3067\u3067\u304d\u307e\u3059\u3002\u816b\u760d\u304c\u5b8c\u5168\u306b\u6d88\u3048\u305f\u3082\u306e(CR)\uff11\u4f8b\uff0c\u304b\u306a\u308a\u5c0f\u3055\u304f\u306a\u3063\u305f\u3082\u306e(PR)\uff11\u4f8b\uff0c\u5c11\u3057\u3067\u3082\u7e2e\u3093\u3060\u3082\u306e(OE)\uff15\u4f8b\uff0c\u5909\u308f\u3089\u306a\u304b\u3063\u305f\u3082\u306e(SD) \uff12\u4f8b\u3067\uff0c\u5168\u3066\u306e\u75c7\u4f8b\u3067\u816b\u760d\u306e\u5897\u5927\u50be\u5411\u304c\u6291\u3048\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002 \u304a\u305d\u3089\u304f\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3084\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u3088\u3046\u306a\u816b\u760d\u306b\u306f\u4f7f\u3048\u308b\u65b9\u6cd5\u3067\u3057\u3087\u3046\u3002<br \/>\n\u89e3\u8aac\uff1a\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u306f\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3068\u3066\u3082\u4f3c\u305f\u5236\u304c\u3093\u5264\u3067\u3059\u3002\u5c0f\u5150\u8133\u816b\u760d\u3092\u542b\u3081\u3066\uff0c\u795e\u7d4c\u81a0\u816b\u306b\u306f\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u306e\u65b9\u304c\u52b9\u679c\u306f\u9ad8\u3044\u3057\uff0c\u904e\u53bb\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u3057\u3063\u304b\u308a\u3057\u305f\u6210\u7e3e\u304c\u3042\u308a\u307e\u3059\u3002\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u306f\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u304c\u3042\u3063\u3066\u4f7f\u3044\u3065\u3089\u3044\u304b\u3089\uff0c\u30d3\u30f3\u30d6\u30e9\u30b9\u30c1\u30f3\u3068\u3044\u3046\u306e\u306f\u77ed\u7d61\u7684\u3059\u304e\u307e\u3059\u306e\u3067\u6c17\u3092\u3064\u3051\u307e\u3057\u3087\u3046\u3002\u3053\u306e\u5831\u544a\u306e\u5f8c\uff0c\u4e16\u754c\u4e2d\u3067\u304b\u306a\u308a\u4f7f\u7528\u3055\u308c\u305f\u3088\u3046\u3067\u3059\u304c\uff0c\u5f53\u521d\u306e\u3053\u306e\u5831\u544a\u3088\u308a\u594f\u529f\u5272\u5408\u306f\u304b\u306a\u308a\u4f4e\u3044\u3082\u306e\u3067\u3059\uff0c\u3067\u3082\u4f7f\u3048\u308b\u85ac\u5264\u3067\u3059\u3002<\/p>\n<h4><strong>\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3078\u306e\u30a2\u30ec\u30eb\u30ae\u30fc<\/strong><\/h4>\n<p>Castells MC, et al.: Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol 122: 574-580, 2008<br \/>\n\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u751f\u3058\u3084\u3059\u3044\u5236\u304c\u3093\u5264\u3067\u3059\u3002\u5c11\u91cf\u3092\u7e70\u308a\u8fd4\u3057\u6295\u4e0e\u3059\u308b\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u751f\u3058\u3084\u3059\u3044\u3068\u3082\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u306b\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u3067\u308b\u3068\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306b\u3082\u30a2\u30ec\u30eb\u30ae\u30fc\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4e21\u8005\u3068\u3082\u306b\u30d7\u30e9\u30c1\u30ca\u88fd\u5264 platinum \u3060\u304b\u3089\u3067\u3059\u3002\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u3078\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\uff0c\u3058\u3093\u307e\u75b9\u306a\u3069\u306e\u8efd\u3044\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u3002\u7e70\u308a\u8fd4\u3057\u6295\u4e0e\u3092\u3059\u308b\u3068\u7a00\u306b\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3068\u3044\u3046\u91cd\u75c7\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u3067\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u5fc5\u305a\u3057\u3082\uff0c\u30d7\u30e9\u30c1\u30ca\u88fd\u5264\u304c\u4f7f\u3048\u306a\u304f\u306a\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002desensitization \u8131\u611f\u4f5c\u3068\u3044\u3046\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002\u5c11\u91cf\u306e\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\u304b\u3089\u5897\u3084\u3057\u3066\u3044\u304f\u65b9\u6cd5\u3067\u3059\u304c\uff0c\u521d\u56de\u306f\u30b7\u30e7\u30c3\u30af\u306b\u306a\u308b\u3068\u3044\u3051\u306a\u3044\u306e\u3067ICU\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3059\u304b\u3089\uff0c\u5316\u5b66\u7642\u6cd5\u306e\u304b\u306a\u308a\u306e\u5c02\u9580\u5bb6\u306b\u3057\u304b\u3067\u304d\u307e\u305b\u3093\u3002rapid desensitization protocol \u306b\u95a2\u3057\u3066\u306f\u591a\u304f\u306e\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\u304b\u306a\u308a\u6709\u52b9\u6027\u306e\u9ad8\u3044<strong><span style=\"color: #000080;\">\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30a8\u30c8\u30dd\u30b7\u30c9<\/span><\/strong>\u3092\u4f7f\u3046\u5316\u5b66\u7642\u6cd5\u306e\u8ad6\u6587<\/h4>\n<p>Massimino M, et al.: High response rate to cisplatin\/etoposide regimen in childhood low-grade glioma. J Clin Oncol 20:4209-4216, 2002<br \/>\n34\u4eba\u306e\u3068\u3066\u3082\u5c0f\u3055\u306a\u5b50\u4f9b\u306b\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u3068\u30a8\u30c8\u30dd\u30b7\u30c9\u3092\u4f7f\u3046\u5316\u5b66\u7642\u6cd5\u304c\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u518529\u4eba\u304c\u8996\u795e\u7d4c\u306b\u816b\u760d\u3092\u6301\u3063\u3066\u3044\u3066\uff0c\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\uff11\u578b\u306e\u60a3\u5150\u306f\uff18\u4eba\u3044\u307e\u3057\u305f\u3002\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3 30mg\/m2\/day, days 1-3\uff0c\u30a8\u30c8\u30dd\u30b7\u30c9 150mg\/m2\/day, days 1-3\u3067\u3059\u3002\u3053\u308c\u30921\u6708\u306b1\u56de\u306710\u30f6\u6708\u7d9a\u3051\u307e\u3059\u3002 \u5b9f\u306b24\u4f8b(71%)\u3067\u816b\u760d\u306e\u7e2e\u5c0f objective response \u304c\u307f\u3089\u308c\uff0c\u5897\u5927\u3057\u305f\u75c7\u4f8b\u306f\u306a\u304b\u3063\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u4eca\u307e\u3067\u767a\u8868\u3055\u308c\u305f\u5316\u5b66\u7642\u6cd5\u306e\u6210\u7e3e\u3067\u306f\u6700\u3082\u6709\u52b9\u6027\uff08\u594f\u52b9\u5272\u5408\uff09\u304c\u9ad8\u3044\u3082\u306e\u3067\u3059\u3002\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306f\u4f7f\u3044\u306b\u304f\u3044\u3051\u3069\uff0c\u6709\u52b9\u6027\u306f\u9ad8\u3044\u3068\u78ba\u8a8d\u3055\u308c\u305f\u3068\u3082\u3044\u3048\u307e\u3059\u3002\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\uff11\u578b\u306e\u60a3\u8005\u3055\u3093\u306e\u5272\u5408(24%)\u304c\u9ad8\u3044\u306e\u304c\u3068\u3066\u3082\u6c17\u306b\u306a\u308a\u307e\u3059\uff08NF-1\u306e\u60a3\u8005\u3055\u3093\u306e\u8996\u795e\u7d4c\u816b\u760d\u306f\u5143\u3005\u4e88\u5f8c\u304c\u3088\u3044\u306e\u3067\u3059\uff09\u3002\u307e\u305f\u5fc3\u914d\u3055\u308c\u305f\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u306e\u8074\u529b\u969c\u5bb3\u306f\u9ad8\u97f3\u57df\u969c\u5bb3\u304c28%\u306b\u307f\u3089\u308c\u305f\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u4f1a\u8a71\u9818\u57df\u3067\u306e\u8074\u529b\u969c\u5bb3\u306f\u306a\u304b\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u3002\u8074\u529b\u306e\u30e2\u30cb\u30bf\u30fc\uff08\u8033\u97f3\u97ff\u653e\u5c04\u691c\u67fb\uff09\u3092\u3082\u3063\u3068\u983b\u56de\u306b\u3059\u308c\u3070\u3053\u306e\u9ad8\u97f3\u57df\u306e\u969c\u5bb3\u3082\u6e1b\u3089\u305b\u308b\u306f\u305a\u3067\u3059\u3002<\/p>\n<h5>\u5b9f\u4f8b<\/h5>\n<h4>NF-1\u306b\u5408\u4f75\u3057\u305f\u5de6\u8996\u795e\u7d4c\u81a0\u816b single optic nerve glioma<\/h4>\n<p>\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u3092\u6301\u3063\u3066\u3044\u308b\uff18\u6b73\u306e\u5b50\u4f9b\u306b\u5de6\u8996\u795e\u7d4c\u306e\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u982d\u84cb\u5185\u816b\u760d\u304c\u5927\u304d\u304b\u3063\u305f\u306e\u3067\uff0c\u3053\u3069\u3082\u75c5\u9662\u30679\u6b73\u306811\u6b73\u306e\u6642\u306b\u958b\u982d\u816b\u760d\u6458\u51fa\u624b\u8853\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u982d\u84cb\u5185\u306e\u90e8\u5206\u306f\u3068\u308c\u305f\u306e\u3067\u3059\u304c\uff0c\u5de6\u306e\u773c\u7aa9\u5185\u8996\u795e\u7d4c\u306b\u816b\u760d\u304c\u6b8b\u308a\u7d4c\u904e\u89b3\u5bdf\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2012.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16417\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2012-297x300.jpg\" alt=\"\" width=\"297\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2012-297x300.jpg 297w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2012-550x555.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2012.jpg 709w\" sizes=\"auto, (max-width: 297px) 100vw, 297px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16418\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-1-295x300.jpg\" alt=\"\" width=\"295\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-1-295x300.jpg 295w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-1-550x559.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-1.jpg 709w\" sizes=\"auto, (max-width: 295px) 100vw, 295px\" \/><\/a><\/p>\n<p>\u5de6\u304c16\u6b73\uff0c\u53f3\u304c23\u6b73\u306e\u6642\u306eMRI\u753b\u50cf\u3067\u3059\u3002\u592a\u304f\u898b\u3048\u305f\u8996\u795e\u7d4c\u304c\uff0c\u5927\u304d\u306a\u584a\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3067\uff0c\u816b\u760d\u306e\u5185\u90e8\u304c\u90e8\u5206\u7684\u306b\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u773c\u7403\u304c\u7a81\u51fa\u3057\u3066\u76ee\u3092\u9589\u3058\u308b\u3053\u3068\u304c\u3067\u304d\u305a\uff0c\u3080\u304d\u51fa\u3057\u306b\u306a\u308a\u307e\u3057\u305f\u30028\u6b73\u304b\u308923\u6b73\u307e\u3067\uff0c15\u5e74\u9593\u304b\u304b\u3063\u3066\u3086\u3063\u304f\u308a\u5927\u304d\u304f\u306a\u3063\u305f\u3057\u773c\u7aa9\u5185\u795e\u7d4c\u81a0\u816b\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16419\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-ct-300x284.jpg\" alt=\"\" width=\"300\" height=\"284\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-ct-300x284.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-ct-550x521.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-ct.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16420\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-2-300x295.jpg\" alt=\"\" width=\"300\" height=\"295\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-2-300x295.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-2-550x541.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-2.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16422\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-3-300x290.jpg\" alt=\"\" width=\"300\" height=\"290\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-3-300x290.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-3-550x532.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2019-3.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\nCT\u3067\u306f\u9ad8\u5ea6\u306e\u773c\u7403\u7a81\u51fa\u304c\u3042\u308a\uff0c\u816b\u760d\u306e\u8fba\u7e01\u304c\u77f3\u7070\u5316\u3057\u3066\u3044\u3066\u8996\u795e\u7d4c\u9798\u3092\u542b\u3081\u3066\u6975\u3081\u3066\u786c\u3044\u7dda\u7dad\u6027\u816b\u760d\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002T2\u5f37\u8abf\u753b\u50cf\u3067\u306f\u9ad8\u4fe1\u53f7\u3067\u816b\u760d\u304c\u5897\u5927\u50be\u5411\u3092\u793a\u3057\uff0c\u4e00\u90e8\u304c\u56a2\u80de\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u4e0b\u306eT1\u5897\u5f37\u50cf\u3067\u306f\u816b\u760d\u306e\u4e2d\u5fc3\u90e8\u5206\u306b\u5897\u5f37\u3055\u308c\u308b\u5897\u6b96\u90e8\u4f4d\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u816b\u760d\u306b\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u3067\u304d\u307e\u305b\u3093\u3057\uff0c\u5316\u5b66\u7642\u6cd5\u3082\u52b9\u304d\u307e\u305b\u3093\u3002\u624b\u8853\u3067\u6458\u51fa\u3059\u308b\u306e\u3067\u3059\u304c\uff0c\u8996\u529b\u304c\u65e2\u306b\u306a\u3044\u306e\u3067\uff0c\u6574\u5bb9\u7684\u306b\uff0c\u5de6\u773c\u7403\u3092\u6e29\u5b58\u3059\u308b\u3053\u3068\uff0c\u77bc\u3068\u773c\u7403\u904b\u52d5\u3092\u6e29\u5b58\u3059\u308b\u3053\u3068\u304c\u76ee\u7684\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u75c5\u7406\u6240\u898b\u3067\u306f\uff0c\u5e7c\u5150\u578b\u306epilomyxoid astrocytoma\u306e\u90e8\u5206\u304c\u6df7\u5728\u3057\u307e\u3059\u3002\u305d\u306e\u90e8\u5206\u304c\u5897\u6b96\u3068\u816b\u760d\u5897\u5927\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002T2\u5f37\u8abf\u753b\u50cf\u3067\u9ad8\u4fe1\u53f7\u3067\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa7-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16428\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa7-he-300x283.jpg\" alt=\"\" width=\"300\" height=\"283\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa7-he-300x283.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa7-he-550x520.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa7-he.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa8-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16432\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa8-he-300x287.jpg\" alt=\"\" width=\"300\" height=\"287\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa8-he-300x287.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa8-he-550x526.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa8-he.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16430\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2-he-300x288.jpg\" alt=\"\" width=\"300\" height=\"288\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2-he-300x288.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2-he-550x528.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa2-he.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawaki-67-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16431\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawaki-67-1-300x291.jpg\" alt=\"\" width=\"300\" height=\"291\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawaki-67-1-300x291.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawaki-67-1-550x534.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawaki-67-1.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>myxoid\u306a\u90e8\u5206\u3067\u3059\u3002\u53f3\u4e0b\u306eMIB-1\u67d3\u8272\u3067\u306f3%\u307b\u3069\u306e\u967d\u6027\u7387\u3067\u3042\u308a\uff0c\u6570\u5e74\u5358\u4f4d\u3067\u306f\u816b\u760d\u5897\u5927\u304c\u3042\u308a\u5f97\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u67d4\u3089\u304b\u304f\u51fa\u8840\u6027\u3067\u5438\u5f15\u6458\u51fa\u3067\u304d\u308b\u90e8\u5206\u306e\u816b\u760d\u3067\u3059\u3002IDH wild type, BRAFV600 wild type, H3K27 wild type, <span style=\"color: #000080;\"><strong>FGFR1 N546K mutation<\/strong><\/span>\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16435\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawagfap-2-300x279.jpg\" alt=\"\" width=\"300\" height=\"279\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawagfap-2-300x279.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawagfap-2-550x511.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawagfap-2.jpg 685w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16436\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he-300x287.jpg\" alt=\"\" width=\"300\" height=\"287\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he-300x287.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he-550x525.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he-768x734.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa1-he.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u539a\u304f\u80a5\u539a\u3057\u305f\u8996\u795e\u7d4c\u9798\u306e\u5185\u90e8\u306e\u8996\u795e\u7d4c\u7d44\u7e54\u306f\u307b\u3068\u3093\u3069\u816b\u760d\u306b\u7f6e\u304d\u63db\u308f\u3063\u3066\u3044\u3066\uff0cGFAP\u3067\u67d3\u8272\u3055\u308c\u9ad8\u5ea6\u306e\u77f3\u7070\u5316\u3092\u4f34\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u816b\u760d\u3068\u3044\u3046\u3088\u308a\u3082\u7622\u75d5\u5316\u3057\u3066\u3057\u307e\u3063\u305f\uff0cadult-type pilocytic astrocytoma\u306b\u8a8d\u3081\u3089\u308c\u308b\u6240\u898b\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16437\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he-300x298.jpg\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he-550x545.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he-768x762.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa6-he.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16438\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he-300x288.jpg\" alt=\"\" width=\"300\" height=\"288\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he-300x288.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he-550x528.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he-768x737.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa5-he.jpg 796w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Rosenthal fiber, eosinophyric granular body, psammoma body\u306a\u3069\u304c\u8a8d\u3081\u3089\u308c\uff0c\u6210\u719f\u3057\u304d\u3063\u3066\u9000\u884c\u5909\u6027\u306b\u79fb\u884c\u3059\u308bpilocytic astrocytoma\u306e\u50cf\u3067\u3059\u3002\u3053\u306e\u90e8\u5206\u306f\u5897\u5927\u3057\u307e\u305b\u3093\u3002\u7dda\u7dad\u6027\u306b\u6975\u3081\u3066\u786c\u3044\u7d44\u7e54\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16423\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20-300x286.jpg\" alt=\"\" width=\"300\" height=\"286\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20-300x286.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20-550x524.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20-768x732.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/pilosawa20.jpg 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n3\u5ea6\u76ee\u306e\u5de6\u524d\u982d\u958b\u982d\u624b\u8853\u3068\u306a\u308a\u307e\u3057\u305f\u304c\uff0c\u7121\u4e8b\u306b\u773c\u7aa9\u5185\u816b\u760d\u306f\u6458\u51fa\u3067\u304d\u3066\uff0c\u773c\u7403\u306f\u6e29\u5b58\u3067\u304d\u307e\u3057\u305f\u3002\u773c\u7403\u5f8c\u6975\u3067\u306e\u8996\u795e\u7d4c\u5207\u65ad\u304c\u3082\u3063\u3068\u3082\u96e3\u3057\u304f\uff0c\u6bdb\u69d8\u4f53\u795e\u7d4c\u3084\u773c\u7403\u306e\u6804\u990a\u52d5\u8108\u306a\u3069\u3092\u6e29\u5b58\u3057\u306a\u3044\u3068\uff0c\u3059\u3050\u306b\u773c\u7403\u840e\u7e2e\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>\u6587\u732e<\/h5>\n<ul>\n<li>Aryan HE, et al.: Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature. Childs Nerv Syst 21: 477-481,\u00a02005<\/li>\n<li>Avery RA, et al.: Marked recovery of vision in children with optic pathway gliomas treated with bevacizumab. JAMA Ophthalmol 132:111-114, 2014<\/li>\n<li>Bouffet E, et al.: Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma. J Clin Oncol 30: 1358-1363, 2012<\/li>\n<li>Cardellicchio S, et al.: Low-dose cisplatin-etoposide regimen for patients with optic pathway glioma: a report of four cases and literature review. Neuropediatrics 45: 42-49, 2014<\/li>\n<li>Castells MC, et al.: Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol 122: 574-580, 2008<\/li>\n<li>Chong AL, et al.: Optic pathway gliomas in adolescence&#8211;time to challenge treatment choices? Neuro Oncol 15: 391-400, 2013<\/li>\n<li>Goodden J, et al: The role of surgery in optic pathway\/hypothalamic gliomas in children. J Neurosurg Pediatr 13:1-12, 2014<\/li>\n<li>Gururangan S et al. Temozolomide in children with progressive low-grade glioma. Neuro-oncol 9: 161-168, 2007<\/li>\n<li>Figueiredo EG, et al.: Leptomeningeal dissemination of pilocytic astrocytoma at diagnosis in childhood: two cases report. Arq Neuropsiquiatr 61: 842-847, 2003<\/li>\n<li>Hwang EI, et al.: Long-term efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatr Blood Cancer 60: 776-782, 2013<\/li>\n<li>Lafay-Cousin L, et al. Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer 103: 2636-2642, 2005<\/li>\n<li>Lassaletta A, et al.: Phase II Weekly Vinblastine for Chemotherapy-Na\u00efve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study. J Clin Oncol. 2016<\/li>\n<li>Massimino M, et al.: High response rate to cisplatin\/etoposide regimen in childhood low-grade glioma. J Clin Oncol 20:4209-4216, 2002<\/li>\n<li>McCowage G, et al.: Successful childhood pilocytic astrocytomas metastatic tu the leptomeninges with high-dose cyclophosphamide. Med Pediatr Oncol 27: 32-39, 1996<\/li>\n<li>Sawamura Y, et al.: Chemotherapy with cisplatin and vincristine for optic pathway\/hypothalamic astrocytoma in young children. Jpn J Clin Oncol\u00a039: 277-283, 2009<\/li>\n<li>Sawamura Y, Kamada K, Kamoshima Y, Yamaguchi S, Tajima T, Tsubaki J, Fujimaki T: Role of Surgery for Optic pathway \/ Hypothalamic Astrocytomas in Children. Neuro Oncol 10: 725-733, 2008<\/li>\n<\/ul>\n<h4>\u8c46\u77e5\u8b58\uff08\u306a\u305c\u8996\u8def optic pathway\u306b\u5e83\u304c\u308b\u306e\u304b\uff09<\/h4>\n<p>\u80ce\u5150\u8133\u306b\u307f\u3089\u308c\u308b\u53cc\u6975\u6027\u306e\u7d30\u80de bipolar-shaped cells\u3092radial glial cell\u3068\u3044\u3044\uff0c\u80ce\u751f\u5f8c\u671f\u306b\u306f\u6d88\u5931\u3057\u307e\u3059\u3002radial glial cell\u306fastrocyte\u306b\u5206\u5316\u3059\u308b\u80fd\u529b\u3082\u6709\u3057\u3066\u3044\u3066\uff0cpilocytic astrocytoma\u306e\u767a\u751f\u6bcd\u5730\u3068\u306a\u308b\u7d30\u80de\u3060\u3068\u8a00\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002radial glia\u306f\uff0coptic axon (optic nerve)\u304c\uff0c\u8996\u795e\u7d4c\u4e73\u982d\u304b\u3089\u8996\u795e\u7d4c\u4ea4\u5dee\u3068\u8996\u7d22\u3092\u7d4c\u7531\u3057\u3066\uff0c\u5916\u5074\u819d\u72b6\u4f53\u3068\u524d\u8996\u84cb\u6838\u3068\u4e0a\u4e18\u306b\u9032\u5c55\u3059\u308b\u306e\u3092\u30ac\u30a4\u30c9\u3059\u308b\u50cd\u304d\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8996\u8def\u306e\u767a\u9054\u306b\u95a2\u9023\u3059\u308bradial glia\u306e\u5206\u5e03\u3068\uff0cpilocytic astrocytoma\u306e\u767a\u751f\u6bcd\u5730\u304c\u985e\u4f3c\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u8c46\u77e5\u8b58\uff08\u306a\u305c\u304b\u591a\u3044\u304f\u3082\u819c\u306e\u3046\u80de\u306e\u5408\u4f75\uff09<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10372\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-768x766.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-550x549.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2014\/07\/piloarachnoidcyst.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><br \/>\n<\/a>\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\u306f\uff0c\u5927\u304d\u306a\u304f\u3082\u819c\u306e\u3046\u80de\u304c\u51fa\u73fe\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u7406\u7531\u306f\u5168\u304f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\uff0c\u7d4c\u904e\u3092\u898b\u3066\u3044\u308b\u3068\u5f90\u3005\u306b\u5927\u304d\u304f\u306a\u3063\u3066\u304f\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u306f\u3042\u308a\u307e\u305b\u3093\u3057\uff0c\u75c7\u5019\u6027\u3068\u306a\u3063\u305f\u3082\u306e\u306f\u898b\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u822c\u7684\u306b\u306f\u5358\u7d14\u306b\u8996\u795e\u7d4c\u81a0\u816b optic glioma\u3068\u547c\u3070\u308c\u307e\u3059 \u8996\u795e\u7d4c\uff0c\u8996\u4ea4\u53c9\uff0c\u8996\u5e8a\u4e0b\u90e8\uff0c\u8996\u7d22\u3001\u5185\u5305\uff0c\u8996\u653e\u7dda\u307e\u3067\u3092\u4fb5\u3059\u816b\u760d\u3067\u3059 \u6b63\u78ba\u306b\u306f\u8996\u8def\u8996\u5e8a\u4e0b\u90e8\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b hypothalamic\/optic pathwa [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-6025","post","type-post","status-publish","format-standard","hentry","category-pediattumor"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/6025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=6025"}],"version-history":[{"count":98,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/6025\/revisions"}],"predecessor-version":[{"id":23154,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/6025\/revisions\/23154"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=6025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=6025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=6025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}