{"id":3709,"date":"2013-09-01T11:08:59","date_gmt":"2013-09-01T02:08:59","guid":{"rendered":"\/sawamura\/?p=3709"},"modified":"2019-11-25T12:38:49","modified_gmt":"2019-11-25T03:38:49","slug":"gliomatosi","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliomatosi\/","title":{"rendered":"\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u3000\u5927\u8133\u795e\u7d4c\u81a0\u816b\u75c7 gliomatosis cerebri\uff0cIDH\u91ce\u751f\u578b\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b"},"content":{"rendered":"<h1><span style=\"color: #ff0000;\">2016\u5e74\u306eWHO\u5206\u985e\u3067\uff0c\u3053\u306e\u816b\u760d\u540d\u306f\u7121\u304f\u306a\u308a\u307e\u3057\u305f\u304c\uff0c<br \/>\n\u6982\u5ff5\u3068\u3057\u3066\u306f\u91cd\u8981\u3067\u3059<\/span><\/h1>\n<h5>IDH\u91ce\u751f\u578b\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b diffuse astrocytoma\u304c\u7570\u5e38\u306b\u5e83\u3044\u9818\u57df\u306b\u6d78\u6f64\u3057\u305f\u81e8\u5e8a\u50cf\u3068\u3055\u308c\u307e\u3059<\/h5>\n<h5>gliomatosis cerebri growth pattern of IDH-wild type diffuse astrocytoma<\/h5>\n<ul>\n<li>\u5927\u8133\u306b\u5e83\u7bc4\u56f2\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u5e83\u304c\u308b\uff08\u6d78\u6f64\u3059\u308b\uff09\u795e\u7d4c\u81a0\u816b \u30b0\u30ea\u30aa\u30fc\u30de\u3092\u793a\u3059\u53e4\u3044\u75c5\u540d\u3067\u3059<\/li>\n<li>2016\u5e74 WHO\u75c5\u7406\u5206\u985e\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>IDH-wild type\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d<\/strong><\/span>\u3068\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u6210\u4eba\u306b\u307f\u3089\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u81e8\u5e8a\u7684\u306b\u306f\u30b0\u30ec\u30fc\u30c94\u3068\u540c\u7b49\u306e\u60aa\u6027\u816b\u760d<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u521d\u767a\u75c7\u72b6\u306f\uff0c\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\uff08\u3051\u3044\u308c\u3093\u767a\u4f5c\uff09\u304c\u6700\u3082\u591a\u304f\uff0c\u9ebb\u75fa\u3084\u5931\u8a9e\u75c7\uff0c\u982d\u75db\uff0c\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306a\u3069\u3067\u3086\u3063\u304f\u308a\u60aa\u5316\u3057\u307e\u3059<\/li>\n<li>MRI\u3067\u8133\u306e\u3068\u3066\u3082\u5e83\u3044\u7bc4\u56f2\uff08\u5de6\u53f3\u306e\u5927\u8133\u304b\u3089\u8133\u5e79\u90e8\u307e\u3067\u306a\u3069\uff09\u306b\u75c5\u5909\u304c\u306b\u3058\u3080\u3088\u3046\u306b\u898b\u3048\u307e\u3059<\/li>\n<li>\u3068\u306b\u304b\u304fdiffuse and infiltrative\u3068\u3044\u3063\u3066\uff0cMRI\u3067<span style=\"color: #000080;\"><strong>\u816b\u760d\u306e\u584a\u304c\u898b\u3048\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u306e\u304c\u5b9a\u7fa9\u3067\u3059<\/li>\n<li>\u901a\u5e38\u306f\u9020\u5f71\u5264\u3067\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\u304c\uff0cMRI\u3067\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u4f8b\u306e\u65b9\u304c\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u584a\u308a\u3092\u4f5c\u3089\u306a\u3044\u3067\uff0c\u8133\u306e\u69cb\u9020\u3092\u4fdd\u3063\u305f\u307e\u307e\u816b\u760d\u7d30\u80de\u304c\u5897\u3048\u3066\u8133\u7d44\u7e54\u306b\u3057\u307f\u8fbc\u3093\u3067\u3044\u304d\u307e\u3059<\/li>\n<li>\u816b\u760d\u7d30\u80de\u304c\u8133\u306e\u4e2d\u3092\u8d70\u308a\u56de\u308b\u3088\u3046\u306b\u5e83\u304c\u3063\u3066\u5897\u3048\u3066\u3044\u304d\u307e\u3059<\/li>\n<li>\u795e\u7d4c\u7d30\u80de\u304c\u7834\u58ca\u3055\u308c\u306a\u3044\u306e\u3067\uff0c\u9ebb\u75fa\u306a\u3069\u306e\u5c40\u6240\u75c7\u72b6\u304c\u51fa\u306a\u3044\u3067\u982d\u75db\u3067\u767a\u75c7\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u624b\u8853\u306f\u751f\u691c\u8853\u3068\u3044\u3046\u8a3a\u65ad\u306e\u305f\u3081\u306b\u307b\u3093\u306e\u5c11\u3057\u816b\u760d\u3092\u3068\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u3057\u307e\u3059<\/li>\n<li>\u624b\u8853\u3067\u75c5\u7406\u8a3a\u65ad\u3092\u3057\u305f\u6642\u306b\uff0c<span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\uff08\u30b0\u30ec\u30fc\u30c92\uff09\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff08\u30b0\u30ec\u30fc\u30c93\uff09\u3042\u308b\u3044\u306f\u81a0\u82bd\u816b\uff08\u30b0\u30ec\u30fc\u30c94\uff09<\/strong><\/span>\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u3069\u306e\u3088\u3046\u306a\u75c5\u7406\u8a3a\u65ad\u304c\u51fa\u3066\u3082\uff0c\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u306e\u75c5\u614b\u3092\u793a\u305b\u3070\u4e88\u5f8c\u306f\u4e0d\u826f<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u306e\u75c5\u7406\u8a3a\u65ad\u30b0\u30ec\u30fc\u30c92\u306e\u75c7\u4f8b\u306e\u4e88\u5f8c\u306f\u30b0\u30ec\u30fc\u30c94\u3068\u3044\u3046\u3084\u3084\u3053\u3057\u3044\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #000000;\">\u307e\u308c\u306b<\/span><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\" href=\"\/sawamura\/braintumors\/olig\/\">\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d<\/a><\/span>\u306e\u75c5\u7406\u50cf\u304c\u6df7\u3058\u308b<\/strong><\/span>\u3053\u3068\u304c\u3042\u308a\uff0c\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3060\u3051\u3088\u308a\u306f\u826f\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u3084\u306f\u308a\u9577\u671f\u751f\u5b58\u306f\u671f\u5f85\u3067\u304d\u307e\u305b\u3093<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3067\u75c5\u52e2\u306e\u9032\u884c\u3092\u4e00\u6642\u7684\u306b\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u5168\u8133\u7167\u5c04<\/strong><\/span> whole brain radiation therapy \u3092\u7528\u3044\u307e\u3059<\/li>\n<li>\u3067\u3082\u5c11\u306a\u304f\u3068\u308240\u30b0\u30ec\u30a4\u4ee5\u4e0a\u306e\u5927\u304d\u306a\u7dda\u91cf\u3092\u7528\u3044\u307e\u3059\u304b\u3089\uff0c\u7167\u5c04\u5f8c\u6570\u30f6\u6708\u304f\u3089\u3044\u3067\u8a8d\u77e5\u6a5f\u80fd\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u304d\u307e\u3059<\/li>\n<li>\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\uff09\u3067\u6709\u52b9\u306a\u3082\u306e\u306f\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3068\u6570\u30f6\u6708\u9593\uff0c\u75c5\u52e2\u306e\u9032\u884c\u304c\u6291\u3048\u3089\u308c\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u3067\u306e<span style=\"color: #ff0000;\"><strong>\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f1\u5e74\u534a<\/strong><\/span>\u304f\u3089\u3044\u3067\uff0c\u81a0\u82bd\u816b\u3068\u540c\u3058\u304f\u3089\u3044\u3067\u3059<\/li>\n<li>\u7121\u6cbb\u7642\u3067\u3059\u3068\uff11\u5e74\u4ee5\u5185\u304f\u3089\u3044\u306e\u751f\u5b58\u671f\u9593\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u6b8b\u5ff5\u306a\u304c\u308910\u5e74\u3092\u8d85\u3048\u308b\u9577\u671f\u751f\u5b58\u4f8b\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<\/ul>\n<h5>\u75c5\u540d\u304c\u306a\u304f\u306a\u3063\u3066\u3082\u7279\u6b8a\u306a\u75c5\u614b\u3068\u3057\u3066\u6349\u3048\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/h5>\n<h5>gliomatosis\u306e\u75c5\u614b\u3092\u8aac\u660e\u3067\u304d\u308bIDH\u4ee5\u5916\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u77e5\u898b\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093<\/h5>\n<h4>MRI\u753b\u50cf\u6240\u898b 60\u4ee3\u3067\u56a5\u4e0b\u969c\u5bb3\u3068\u69cb\u97f3\u969c\u5bb3\u3067\u767a\u75c7\u3057\u305f\u4f8b<\/h4>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0005.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14484\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0005-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0006.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14485\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0006-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0007.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14486\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0007-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0008.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14487\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0008-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0009.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14488\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0009-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14489\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010-768x763.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010-550x547.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0010.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>\u5ef6\u9ac4\u304b\u3089\u4e2d\u8133\u307e\u3067\u816b\u760d\u304c\u3042\u3063\u3066\u8133\u5e79\u90e8\u304c\u816b\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u753b\u50cf\u3067\u3059\u3068\uff0c\u5c0f\u5150\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\uff08DIPG\uff0c\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\uff09\u306e\u3088\u3046\u306b\u898b\u3048\u307e\u3059<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0011.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14490\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0011-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14491\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012-768x772.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012-550x553.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0012.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0013.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14492\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0013-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0013-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0013-298x300.jpg 298w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0014.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14493\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0014-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0015.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14494\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktflair.0015-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktgad.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-14495\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/09\/gliomatosisktgad-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>\u4e21\u5074\u8996\u5e8a\u304b\u3089\u5927\u8133\u57fa\u5e95\u6838\uff0c\u4e21\u5074\u5927\u8133\u534a\u7403\u6df1\u90e8\u767d\u8cea\uff0c\u8133\u6881\u307e\u3067\u5e83\u7bc4\u56f2\u306b\u816b\u760d\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u3088\u3046\u306b\u307e\u3060\u3089\u306b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\u8a3a\u65ad\u3067\u6c17\u3092\u3064\u3051\u308b\u3053\u3068<\/h4>\n<p>\u4e21\u5074\u306e\u5927\u8133\u534a\u7403\u306e\u6df1\u90e8\u767d\u8cea\u306b\u8133\u6881\u3092\u8d8a\u3048\u3066\u5e83\u304c\u308b\u4e4f\u7a81\u8d77\u81a0\u816b\u3092\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u3068\u8a3a\u65ad\u3057\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u3067\u3082\uff0c\u3053\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u4e88\u5f8c\u306f\u826f\u3044\u306e\u3067\u5927\u304d\u306a\u7dda\u91cf\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002<span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\" href=\"\/sawamura\/braintumors\/olig\/\">\u5b9f\u4f8b\u304c\u4ed6\u306e\u30da\u30fc\u30b8\u306b\u3042\u308a\u307e\u3059\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09\u3002<\/a><\/span><\/p>\n<h4>\u30e1\u30a4\u30e8\u30af\u30ea\u30cb\u30c3\u30af\u304b\u3089\u306e\u5831\u544a<\/h4>\n<p>Chen S, et al.: Gliomatosis cerebri: clinical characteristics, management, and outcomes. J Neurooncol 112: 267-275, 2013<br \/>\n1991\u5e74\u304b\u30892008\u5e74\u304b\u3089\u306e54\u4f8b\u304c\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u3002\u5b9a\u7fa9\u306f\uff0c\u3073\u307e\u3093\u6027\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u75c5\u7406\u5b66\u7684\u306b\u8a3c\u660e\u3055\u308c\u3066\u3044\u3066\uff0c\u5927\u8133\uff13\u8449 three lobes\u4ee5\u4e0a\u306b\u307e\u305f\u304c\u308b\u3082\u306e\u3067\u3059\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f18.5\u30f6\u6708\u3068\u81a0\u82bd\u816b\u3068\u307b\u3068\u3093\u3069\u304b\u308f\u308a\u307e\u305b\u3093\u3002\u9ad8\u9f62\u8005\u3068\u72b6\u614b\u306e\u60aa\u3044\u60a3\u8005\u3055\u3093\u3067\u306e\u4e88\u5f8c\u304c\u60aa\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c92\u306e\u75c5\u7406\u50cf\u3092\u6709\u3059\u308b\u3082\u306e\u306734\u30f6\u6708\uff0c\u30b0\u30ec\u30fc\u30c94\u306e\u75c5\u7406\u50cf\u3092\u307f\u308b\u30688.5\u30f6\u6708\u306e\u751f\u5b58\u671f\u9593\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u304b\u3051\u305f\u7fa4\u3067\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c16.5\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3057\u306a\u304b\u3063\u305f\u7fa4\u30674.5\u30f6\u6708\u3067\u3057\u305f\u3002<\/p>\n<h4>\u5927\u304d\u306a\u7d71\u8a08<\/h4>\n<p>Taillibert S, et al.: Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol 76: 201-205, 2006<br \/>\n\u6587\u732e\u3068ANOCEF\u304b\u3089\u306e296\u4f8b\u3092\u89e3\u6790\u3057\u305f\u30d1\u30ea\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u767a\u75c7\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u306f42\u6b73<\/strong><\/span>\u3067\u3059\u3002<strong><span style=\"color: #000080;\">\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f14.5\u30f6\u6708<\/span><\/strong>\u3067\u3057\u305f\u3002\u82e5\u304f\u3066\u72b6\u614b\u304c\u826f\u304f\u3066\u75c5\u7406\u8a3a\u65ad\u3067\u30b0\u30ec\u30fc\u30c9\u304c\u4f4e\u3044\u65b9\u4e88\u5f8c\u304c\u3088\u304f\uff0c\u30b0\u30ec\u30fc\u30c92\u3067\u306f20\u30f6\u6708\uff0c\u30b0\u30ec\u30fc\u30c93\u3067\u306f11.5\u30f6\u6708\uff0c\u30b0\u30ec\u30fc\u30c94\u3067\u306f8.5\u30f6\u6708\u3067\u3059\u3002\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u306f\uff0c\u3053\u306e\u30b0\u30ec\u30fc\u30c92\u661f\u7d30\u80de\u816b\u3068\u3044\u3046\u8a3a\u65ad\u3067\u306e\u751f\u547d\u4e88\u5f8c\u304c20\u30f6\u6708\u3057\u304b\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u4e00\u65b9\u3067\uff0c\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u306a\u3044\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f4\u5e74\u3092\u8d85\u3048\u308b\u306e\u3067\u3059\u3002\u307e\u308c\u306b\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u306e\u75c5\u7406\u50cf\u306b\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u90e8\u5206\u50cf\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\uff0c\u305d\u306e\u3088\u3046\u306a\u4f8b\u3067\u306f\u5c11\u3057\u3060\u3051\u751f\u5b58\u671f\u9593\u304c\u9577\u3044\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>\u7070\u767d\u8cea\u3092\u4fb5\u3055\u306a\u3044\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u306e\u65b9\u304c\u5316\u5b66\u7642\u6cd5\u53cd\u5fdc\u6027\u304c\u826f\u3044<\/h4>\n<p align=\"left\">Kaloshi G, et al.: Gray matter involvement predicts chemosensitivity and prognosis in gliomatosis cerebri. Neurology 73: 445-449, 2009<br \/>\n\u30d5\u30e9\u30f3\u30b9\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u8133\u306b\u306f\u767d\u8cea\u3068\u7070\u767d\u8cea\u3068\u3044\u3046\u3068\u3053\u308d\u304c\u3042\u308a\u307e\u3059\u3002\u7070\u767d\u8cea\u306f\u795e\u7d4c\u7d30\u80de\u304c\u5b58\u5728\u3059\u308b\u3068\u3053\u308d\u3067\u3059\u3002\u3053\u306e\u7070\u767d\u8cea\u3092\u3088\u308a\u591a\u304f\u4fb5\u3059\uff08\u816b\u760d\u304c\u4e2d\u306b\u5165\u308a\u8fbc\u3080\uff09\u3082\u306e\u306e\u307b\u3046\u304c\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u3068\u306e\u3053\u3068\u3067\u3059\u300271\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u89e3\u6790\u3055\u308c\u305f\u3068\u3053\u308d\u3067\u306f\uff0c\u7070\u767d\u8cea\u3092\u304a\u304b\u3059\u5272\u5408\u304c\u4f4e\u3044\u4f8b\u3067\u306f\u30c6\u30e2\u30c0\u30fc\u30eb upfront chemotherapy\u3078\u306e\u53cd\u5fdc\u304c\u3088\u304f\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c56\u30f6\u6708\u3068\u975e\u5e38\u306b\u9577\u304f\uff0c1p\/19q\u6b20\u5931\u5272\u5408\u304c\u9ad8\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u306e\u6210\u5206\u304c\u591a\u3044\u8a33\u3067\u306f\u306a\u304b\u3063\u305f\u3068\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u3053\u306e\u8ad6\u6587\u306f\u6ce8\u610f\u3057\u3066\u8aad\u307e\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c56\u30f6\u6708\u306b\u3082\u53ca\u3093\u3067\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u30b0\u30ea\u30aa\u30de\u30c8\u30fc\u30b7\u30b9\u3067\u306f\u3042\u308a\u5f97\u306a\u3044\u307b\u3069\u826f\u3044\u6210\u7e3e\u3067\u3059\u3002\u4e21\u6e2c\u7bc4\u7d1a\u306b\u307e\u305f\u304c\u3063\u3066\u304a\u3068\u306a\u3057\u3044\u5e83\u7bc4\u56f2\u306e\u30b0\u30ec\u30fc\u30c92\u4e4f\u7a81\u8d77\u81a0\u816b\u3084\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3092\u75c7\u4f8b\u3068\u3057\u3066\u542b\u3093\u3067\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u7591\u308f\u308c\u307e\u3059\u3002<\/p>\n<h4>\u5c0f\u5150\u4f8b\u306e\u5831\u544a<\/h4>\n<p>Armstrong GT, et al.: Gliomatosis cerebri: 20 years of experience at the Children&#8217;s Hospital of Philadelphia. Cancer 107: 1597-606, 2006<br \/>\nLandi A, et al.: Gliomatosis cerebri in young patients&#8217; report of three cases and review of the literature. Childs Nerv Sys 27: 19-25, 2011<br \/>\n2006\u5e74\u306e\u30d5\u30a3\u30e9\u30c7\u30eb\u30d5\u30a3\u30a2\u5c0f\u5150\u75c5\u9662\u304b\u3089\u306e\u5831\u544a\u3067\uff0c\u6587\u732e\u4e0a\u306f51\u4f8b\u306e\u5c0f\u5150\u4f8b\u306e\u5831\u544a\u304c\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<strong><span style=\"color: #000080;\">2\u5e74\u5168\u751f\u5b58\u5272\u5408\u306f64%<\/span><\/strong>\u3067\u3057\u305f\u304c\uff0c10\u6b73\u4ee5\u4e0b\u306e\u65b9\u304c\u751f\u547d\u4e88\u5f8c\u306f\u7279\u306b\u77ed\u304b\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u4e00\u65b9\uff0c2011\u5e74\u306e\u30ed\u30fc\u30de\u5927\u5b66\u304b\u3089\u306e\u5831\u544a\u3067\uff0c<strong><span style=\"color: #000080;\">10\u6b73\u4ee5\u4e0b\u306e25\u4f8b\u3067\u306f\u751f\u5b58\u671f\u9593\u306f2\u5e74\u524d\u5f8c<\/span><\/strong>\u3067\u3042\u308a\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3057\u3066\u307f\u308b\u4fa1\u5024\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u3068\u653e\u5c04\u7dda\u3067\u816b\u760d\u304c\u6d88\u3048\u305f\u3068\u3044\u3046\uff11\u4f8b\u5831\u544a<\/h4>\n<p>Mattox AK, et al.: Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy. Clin Neurol Neurosurg 114: 299-306, 2012<br \/>\n\u30c7\u30e5\u30fc\u30af\u5927\u5b66\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u304b\u3089\u4fe1\u7528\u5ea6\u306f\u9ad8\u3044\u3067\u3059\u3002\u4e00\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u901a\u5e38\u91cf\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u5168\u8133\u7167\u5c04 50\u30b0\u30ec\u30a4\u306e\u6cbb\u7642\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u6cbb\u7642\u5f8c\u816b\u760d\u304c\u5b8c\u5168\u306b\u6d88\u5931\u3057\u306638\u30f6\u6708\u306e\u89b3\u5bdf\u671f\u9593\u3067\u306f\u518d\u767a\u306f\u306a\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u901a\u5e38\u306f\uff0c50\u30b0\u30ec\u30a4\u3068\u3044\u3046\u5927\u91cf\u306e\u7dda\u91cf\u3092\u5168\u90e8\u306e\u8133\u306b\u7167\u5c04\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u306a\u3055\u308c\u307e\u305b\u3093\u3002\u304b\u306a\u308a\u9ad8\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3068\u4eba\u683c\u306e\u5909\u5316\u304c\u751f\u3058\u308b\u6cbb\u7642\u7dda\u91cf\u3060\u304b\u3089\u3067\u3059\u3002<\/p>\n<h4>\u75c5\u7406\u50cf<\/h4>\n<p>\u5927\u8133\u81a0\u816b\u75c7 gliomatosis cebri \u3068\u306f\u816b\u760d\u6027\u661f\u7d30\u80de\u304c\u7d50\u7bc0 (solid mass) \u3092\u4f5c\u3089\u305a\uff0c\u3073\u307e\u3093\u6027\u306b\u767a\u80b2\u3057\u3066\u8133\u306e\u5e83\u7bc4\u306a\u90e8\u4f4d\uff0c\u6642\u3068\u3057\u3066\u306f\u5168\u8133\u306b\u304a\u3088\u3073\uff0c \u4e00\u90e8\u4f4d\u304b\u3089\u306e\u767a\u751f\u30fb\u6d78\u6f64\u3068\u306f\u8003\u3048\u3089\u308c\u306a\u3044\u3088\u3046\u306a\u3082\u306e\u3092\u6307\u3057\u307e\u3059\u3002\u58ca\u6b7b\u3084\u56a2\u80de\u5f62\u6210\u3092\u4f34\u3046\u3053\u3068\u304c\u306a\u304f\uff0c\u816b\u760d\u6027\u661f\u7d30\u80de\u306e\u5897\u52a0\u306e\u307f\u3092\u8a8d\u3081\u307e\u3059\u3002\u81e8\u5e8a\u7684\u306b\u306f\uff0c\u4eba\u683c\u306e\u5909\u5316\u3084\u75f4\u5446\u306a\u3069\u3067\u767a\u75c7\u3057\uff0c\u7d4c\u904e\u4e2d\u306b\u4e0d\u5168\u9ebb\u75fa\u306a\u3069\u306e\u5c40\u6240\u75c7\u72b6\u3084\uff0c\u75d9\u6523\uff0c\u3046\u3063\u8840\u4e73\u982d\u3082\u52a0\u308f\u3063\u3066\u304d\u307e\u3059\u3002\u81e8\u5e8a\u75c7\u72b6\u306e\u307f\u3067\u306e\u8a3a\u65ad\u306f\u56f0\u96e3\u3067\uff0c\u53e4\u304f\u306f\u5256\u691c\u306b\u3088\u3063\u3066\u306e\u307f\u78ba\u5b9a\u8a3a\u65ad\u304c\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u306f\u771f\u306egliomatosis cerebri\u3092\u898b\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u304f\uff0c\u3042\u308b\u7a2e\u306e\u661f\u7d30\u80de\u816bdiffuse astrocytoma\u306e\u5e83\u7bc4\u4f38\u5c55\u50cf\u3092gliomatosis\u3068\u8a3a\u65ad\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n<h4><strong>\u00a0\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>Armstrong GT, et al.: Gliomatosis cerebri: 20 years of experience at the Children&#8217;s Hospital of Philadelphia. Cancer 107: 1597-606, 2006<\/li>\n<li>Chen S, et al.: Gliomatosis cerebri: clinical characteristics, management, and outcomes. J Neurooncol 112: 267-275, 2013<\/li>\n<li>Elshaikh MA, et al.: Gliomatosis cerebri: treatment results with radiotherapy alone. Cancer 95:2027-2031, 2002<\/li>\n<li>Kaloshi G, et al.: Gray matter involvement predicts chemosensitivity and prognosis in gliomatosis cerebri. Neurology 73: 445-449, 2009<\/li>\n<li>Landi A, et al.: Gliomatosis cerebri in young patients&#8217; report of three cases and review of the literature. Childs Nerv Sys 27: 19-25, 2011<\/li>\n<li>Mattox AK, et al.: Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy. Clin Neurol Neurosurg 114: 299-306, 2012<\/li>\n<li>Rajz GG, et al.: Presentation patterns and outcome of gliomatosis cerebri. Oncol Lett 3: 209-213, 2012<\/li>\n<li>Taillibert S, et al.: Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol 76: 201-205, 2006<\/li>\n<li>Vates GE, et al.: Gliomatosis cerebri: a review of 22 cases. Neurosurgery 53: 261-71, 2003<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>2016\u5e74\u306eWHO\u5206\u985e\u3067\uff0c\u3053\u306e\u816b\u760d\u540d\u306f\u7121\u304f\u306a\u308a\u307e\u3057\u305f\u304c\uff0c \u6982\u5ff5\u3068\u3057\u3066\u306f\u91cd\u8981\u3067\u3059 IDH\u91ce\u751f\u578b\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b diffuse astrocytoma\u304c\u7570\u5e38\u306b\u5e83\u3044\u9818\u57df\u306b\u6d78\u6f64\u3057\u305f\u81e8\u5e8a\u50cf\u3068\u3055\u308c\u307e\u3059 gliomatosis c [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-3709","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/3709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=3709"}],"version-history":[{"count":31,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/3709\/revisions"}],"predecessor-version":[{"id":14506,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/3709\/revisions\/14506"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=3709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=3709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=3709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}