{"id":23755,"date":"2025-11-18T12:34:20","date_gmt":"2025-11-18T03:34:20","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/sawamura\/?p=23755"},"modified":"2026-01-20T11:13:43","modified_gmt":"2026-01-20T02:13:43","slug":"gliioma-voranigo","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliioma-voranigo\/","title":{"rendered":"\u30dc\u30e9\u30cb\u30b4\u9320 10mg, 40mg (\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6)"},"content":{"rendered":"<h5>2025\u5e749\u6708\u306b\u65e5\u672c\u30bb\u30eb\u30f4\u30a3\u30a8\u793e\u304c\u767a\u58f2\u3057\u307e\u3057\u305f<\/h5>\n<h5>\u9069\u5fdc\uff1a<i>IDH1<\/i>\u53c8\u306f<i>IDH2<\/i>\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u306e<a class=\"indication-block\" href=\"https:\/\/www.kegg.jp\/medicus-bin\/drug_indication?id=180\">\u795e\u7d4c\u81a0\u816b<\/a><\/h5>\n<ul>\n<li>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u3092\u6295\u4e0e\u3059\u308b\u3068\u5909\u7570\u578b\u306eIDH1\/2\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6291\u3048\u307e\u3059<\/li>\n<li>\u816b\u760d\u7d30\u80de\u5185\u306e2-HG\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068<span style=\"color: #000080;\"><strong>\u816b\u760d\u7d30\u80de\u306e\u5897\u6b96\u80fd\u304c\u4f4e\u304f\u306a\u3063\u3066\u816b\u760d\u5897\u5927\u3092\u6291\u5236\u3057\u307e\u3059<\/strong><\/span><\/li>\n<li><span style=\"color: #ff0000;\"><span style=\"color: #333333;\">\u901a\u5e38\u306e\u4f7f\u7528\u3067\u306f\uff0c<\/span><strong>\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u304b\u4e4f\u7a81\u8d77\u81a0\u816b<\/strong><\/span>\uff0cIDH1\/2\u5909\u7570\u304c\u3042\u308b\u3053\u3068<\/li>\n<li>\u624b\u8853\u5f8c\u3067\u751f\u691c\u8853\u3067\u3082\u90e8\u5206\u6458\u51fa\u3067\u3082\u5168\u6458\u51fa\u3067\u3082\u6295\u4e0e\u3067\u304d\u307e\u3059<\/li>\n<li>CYP1A2\u306b\u3088\u308a\u4ee3\u8b1d\u3055\u308c\u308b\u306e\u3067\uff0cCYP1A2\u306e\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u85ac\u5264\u3068\u306e\u4f75\u7528\u306b\u6ce8\u610f\u3057\u307e\u3059<\/li>\n<li>\u65e5\u672c\u30bb\u30eb\u30f4\u30a3\u30a8\u304c\uff0c\u300cIDH1\u53c8\u306fIDH2\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u306e\u795e\u7d4c\u81a0\u816b\u300d\u3092\u5bfe\u8c61\u75be\u60a3\u306b\u627f\u8a8d\u7533\u8acb\u3057\u305f\u306e\u3067\uff0c\u5b9f\u969b\u306b\u306f\u304b\u306a\u308a\u305f\u304f\u3055\u3093\u306e\u7d44\u7e54\u578b\u306b\u4f7f\u7528\u3055\u308c\u3066\u304f\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3042\u308b\u3044\u306f\u4ed6\u306e\u5316\u5b66\u7642\u6cd5\u5264\uff08\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9 \u306a\u3069\uff09\u304c\u512a\u5148\u3055\u308c\u308b\u3068\u5224\u65ad\u3055\u308c\u308b\u5834\u5408\u306b\u306f\u4f7f\u7528\u3059\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li><\/li>\n<\/ul>\n<h5><span style=\"color: #ff0000;\">\u6ce8\u610f\uff1a\u661f\u7d30\u80de\u816b\u3084\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u6d88\u3048\u3066\u7121\u304f\u306a\u3063\u3066\u6cbb\u3063\u3066\u3057\u307e\u3046\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/h5>\n<h5><span style=\"color: #ff0000;\">\u3042\u304f\u307e\u3067\u3082\u816b\u760d\u3092\u5c0f\u3055\u304f\u3057\u305f\u308a\u6210\u9577\u3092\u9045\u304f\u3057\u305f\u308a\u3059\u308b\u9759\u7684\u4f5c\u7528\u3067\u3059<\/span><\/h5>\n<h5><span style=\"color: #ff0000;\"><strong>\u9577\u671f\u670d\u7528\u304c\u5fc5\u8981\u306a\u306e\u3067\uff0c\u8ab0\u306b\u3044\u3064\u3069\u306e\u304f\u3089\u3044\u306e\u9577\u3055\u3067\u6295\u4e0e\u3057\u3066\u4e2d\u65ad\u3059\u308b\u304b\u3092\u6c7a\u3081\u308b\u306e\u304c\u3068\u3066\u3082\u96e3\u3057\u3044\u306e\u3067\u3059<\/strong><\/span><\/h5>\n<h2><\/h2>\n<h5>\u30dc\u30e9\u30cb\u30b4\u306e\u4f7f\u3044\u65b9\uff1a\u304a\u8179\u6e1b\u3063\u3066\u308b\u6642\u306b\u98f2\u3080<\/h5>\n<ul>\n<li>10mg\u306840mg\u306e\u9320\u5264\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u7d4c\u53e3\u6295\u4e0e\u3067\u30dc\u30e9\u30cb\u30b440mg\u3092\u6bce\u65e5\u4e00\u56de\uff0c\u6c7a\u307e\u3063\u305f\u540c\u3058\u6642\u9593\u306b\u670d\u7528\u3057\u307e\u3059<\/span><\/strong><\/li>\n<li>\u7a7a\u8179\u6642\u306b\u306e\u307f\u307e\u3059\uff0c\u671d\u98df\u5f8c\u3068\u304b\uff0c\u5915\u98df\u5f8c\u3068\u304b\u3067\u3059\u3002\u565b\u307e\u305a\u306b\u98f2\u307f\u8fbc\u307f\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\u98df\u4e8b\u304b\u3089\u306f\u304b\u306a\u308a\u6642\u9593\u3092\u7a7a\u3051\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u5bfe\u8c61\u306f\uff0c12\u6b73\u4ee5\u4e0a<\/span><\/strong><\/li>\n<li>\n<div>\u4f53\u91cd\u306f\uff0c40kg\u672a\u6e80\uff1a20mg \u00a0 \u00a040kg\u4ee5\u4e0a\uff1a40mg<\/div>\n<\/li>\n<li>\u60a3\u8005\u3055\u3093\u306e\u72b6\u614b\u3067\u9069\u5b9c\u5897\u6e1b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059<\/li>\n<li>10mg\u4ee5\u4e0b\u306e\u5bb9\u91cf\u306b\u306a\u308b\u3068\u304d\u306f\u4e2d\u6b62\u3057\u307e\u3059<\/li>\n<\/ul>\n<h5>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\uff1a\u809d\u81d3\u306b\u6ce8\u610f\uff01<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-23079\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib-235x300.png\" alt=\"\" width=\"235\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib-235x300.png 235w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib.png 434w\" sizes=\"auto, (max-width: 235px) 100vw, 235px\" \/><br \/>\n<span style=\"color: #000080;\"><strong>\u5026\u6020\u611f\uff0c\u75b2\u52b4\u611f\uff0c<\/strong><strong>\u982d\u75db\uff0c\u5614\u6c17\uff0c\u4e0b\u75e2<\/strong><\/span>\uff0c<strong><span style=\"color: #000080;\">\u98df\u6b32\u6e1b\u9000<\/span><\/strong>\uff0c\u7b4b\u8089\u75db\uff08\u9aa8\u683c\u7b4b\u75db\uff09\uff0c\u95a2\u7bc0\u75db\uff0c<strong><span style=\"color: #000080;\">\u4fbf\u79d8<\/span><\/strong>\uff0c\u98a8\u90aa\u306a\u3069\u306e\u611f\u67d3\u75c7\uff0c\u7a00\u306b\u3066\u3093\u304b\u3093\u767a\u4f5c<br \/>\n\u8840\u6db2\u691c\u67fb\u3067\u306f\uff0cALT, AST, \u03b3-GTP, ALP, \u30d3\u30ea\u30eb\u30d3\u30f3\u4e0a\u6607\uff0c\u597d\u4e2d\u7403\u6e1b\u5c11\u3067\u3059\u3002\u81d3\u5668\u969c\u5bb3\u3067\u306f\u809d\u969c\u5bb3\u304c\u3082\u3063\u3068\u3082\u983b\u5ea6\u304c\u9ad8\u3044\u3067\u3059\u3002<br \/>\n\u3072\u3069\u3044<span style=\"color: #000080;\"><strong>\u5026\u6020\u611f\u304c\u65e5\u5e38\u751f\u6d3b\u306e\u969c\u5bb3<\/strong><\/span>\u3068\u306a\u308a\u307e\u3059\u304c\uff0c\u4f53\u529b\u3092\u306a\u304f\u3055\u306a\u3044\u7a0b\u5ea6\u306b\u904b\u52d5\u3057\u3066\uff0c\u307e\u305f\u5927\u4e8b\u306a\u4ed5\u4e8b\u306e\u305f\u3081\u306b\u4f11\u61a9\u3092\u3068\u3063\u3066\u3068\u3044\u3046\u30d0\u30e9\u30f3\u30b9\u304c\u5927\u5207\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\n\u81d3\u5668\u969c\u5bb3\u3067\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u91cd\u7be4\u306a\u809d\u969c\u5bb3<\/strong><\/span>\u304c\u554f\u984c\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u6bce\u56de\u63a1\u8840\u3092\u3057\u3066\uff0c\u809d\u6a5f\u80fd\u306e\u30c1\u30a7\u30c3\u30af\u3092\u3057\u307e\u3059<br \/>\n\u5438\u6e7f\u6027\u304c\u3042\u308b\u306e\u3067\u5206\u5305\u3067\u304d\u307e\u305b\u3093\u3002\u4e0a\u306b\u3042\u308b\u3088\u3046\u306a<span style=\"color: #000080;\"><strong>\u30dc\u30c8\u30eb\u3092\u3044\u305f\u3060\u3044\u3066\u4fdd\u5b58<\/strong><\/span>\u3057\u3066\u304f\u3060\u3055\u3044<br \/>\n\u7537\u6027\u3067\u306f\uff0c\u7121\u7cbe\u5b50\u75c7\uff08\u7537\u6027\u4e0d\u598a\u75c7\uff09\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025\u5e749\u6708\u306b\u65e5\u672c\u30bb\u30eb\u30f4\u30a3\u30a8\u793e\u304c\u767a\u58f2\u3057\u307e\u3057\u305f \u9069\u5fdc\uff1aIDH1\u53c8\u306fIDH2\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u306e\u795e\u7d4c\u81a0\u816b \u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u3092\u6295\u4e0e\u3059\u308b\u3068\u5909\u7570\u578b\u306eIDH1\/2\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6291\u3048\u307e\u3059 \u816b\u760d\u7d30\u80de\u5185\u306e2-HG\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u816b\u760d\u7d30\u80de [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-23755","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/23755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=23755"}],"version-history":[{"count":2,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/23755\/revisions"}],"predecessor-version":[{"id":24000,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/23755\/revisions\/24000"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=23755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=23755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=23755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}