{"id":2147,"date":"2013-01-31T09:12:48","date_gmt":"2013-01-31T00:12:48","guid":{"rendered":"\/sawamura\/?p=2147"},"modified":"2022-09-10T09:09:54","modified_gmt":"2022-09-10T00:09:54","slug":"astroblastoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/astroblastoma\/","title":{"rendered":"\u661f\u82bd\u816b\uff08\u661f\u82bd\u7d30\u80de\u816b\uff09 astroblastoma MN1-altered"},"content":{"rendered":"<h1>\u30a2\u30b9\u30c8\u30ed\u30d6\u30e9\u30b9\u30c8\u30fc\u30de\u00a0WHO \u30b0\u30ec\u30fc\u30c9\u4e0d\u660e<\/h1>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">\u30a2\u30b9\u30c8\u30ed\u30d6\u30e9\u30b9\u30c8\u30fc\u30de<\/span><\/strong>\u3068\u547c\u3070\u308c\u308b\u306e\u304c\u666e\u901a\u3067\u3059<\/li>\n<li><strong style=\"color: #000080;\">\u3068\u3066\u3082\u307e\u308c\u306a\u816b\u760d<\/strong>\u3067\uff0c\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u3042\u307e\u308a\u306a\u3044\u306e\u3067\uff0c\u6cbb\u7642\u6cd5\u3084\u4e88\u5f8c\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u305b\u3093<\/li>\n<li><span style=\"color: #000080;\"><strong>\u82e5\u3044\u6210\u4eba\u3068\u5b50\u3069\u3082\u306b<\/strong><\/span>\u307f\u3089\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u5973\u6027\u306b\u591a\u3044<\/strong><\/span>\u816b\u760d\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u5927\u304d\u306a\u816b\u760d<\/strong><\/span>\u306b\u306a\u3063\u3066\u304b\u3089\u767a\u898b\u3055\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u982d\u75db\u3084\u5410\u304d\u6c17<\/strong><\/span>\uff0c\u5455\u5410\u304c\u75c7\u72b6\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6cbb\u7642\u306f\uff0c\u624b\u8853\u3067\u5168\u90e8\u3068\u308b<\/strong><\/span>\u3053\u3068\u3067\u3059<\/li>\n<li>\u5927\u8133\u534a\u7403\u306b\u767a\u751f\u3059\u308b\u3082\u306e\u3067\u3059<\/li>\n<li>\u816b\u760d\u306f\u5927\u8133\u306b\u98df\u3044\u8fbc\u3093\u3067\u5927\u304d\u3044\u306e\u3067\u3059\u304c\uff0c\u304f\u308a\u3093\u3068\u3057\u305f\u56fa\u307e\u308a\u3067\u5168\u90e8\u3068\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059<\/li>\n<li>\u5206\u5316\u578b\u3067\u75c5\u7406\u5b66\u7684\u306b\u826f\u6027\u306e\u3082\u306e\u306f\uff0c\u3046\u308c\u3057\u3044\u3053\u3068\u306b<span style=\"color: #000080;\"><strong>\u624b\u8853\u3060\u3051\u3067\u6cbb\u308b\u816b\u760d<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u9ad8\u5ea6\u306e\u75c5\u7406\u5b66\u7684\u60aa\u6027\u50cf\u3092\u793a\u3059\u3082\u306e\u306e\u4e88\u5f8c\u306f\u4e0d\u826f\u3067\u3059<\/li>\n<li>\u624b\u8853\u3067\u53d6\u308a\u6b8b\u3057\u305f\u816b\u760d\u306b<span style=\"color: #000080;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u3066\u3082\u6709\u52b9\u6027\u306f\u4f4e\u3044<\/strong><\/span>\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u75c5\u7406\u8a3a\u65ad\u3067\u306f\uff0c\u300c\u5927\u8133\u306e\u4e0a\u8863\u816b\u300d\u3068\u8aa4\u8a3a\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<\/ul>\n<h4>\u75c7\u72b6<\/h4>\n<ul>\n<li>\u9589\u585e\u6027\u6c34\u982d\u75c7\u306b\u3088\u308b\u982d\u84cb\u5185\u5727\u4ea2\u9032\u306e\u305f\u3081\u306e\u982d\u75db\u3068\u5614\u5410\u3067\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u816b\u760d\u306e\u767a\u751f\u90e8\u4f4d\u306b\u5fdc\u3058\u305f\u5927\u8133\u75c7\u72b6\u304c\u307f\u3089\u308c\u307e\u3059<\/li>\n<\/ul>\n<h4>\u767a\u751f\u90e8\u4f4d<\/h4>\n<p>\u5927\u8133\u306b\u767a\u751f\u3057\uff0c\u524d\u982d\u8449\uff0c\u982d\u9802\u8449\uff0c\u5074\u982d\u8449\u306b\u591a\u304f\uff0c\u6975\u3081\u3066\u307e\u308c\u306b\uff0c\u5c0f\u8133\uff0c\u8996\u5e8a\u4e0b\u90e8\uff0c\u8133\u5e79\u90e8\uff0c\u8996\u795e\u7d4c\u306a\u3069\u306e\u767a\u751f\u4f8b\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059<\/p>\n<h4>\u8a3a\u65ad<\/h4>\n<ul>\n<li>\u5927\u8133\u8868\u5728\u6027\u306e\u3082\u306e\u304c\u591a\u304f\uff0c\u7d50\u7bc0\u69d8\u3067\u306e\u3046\u80de\u6027\u3068\u8868\u73fe\u3055\u308c\u307e\u3059<\/li>\n<li>\u816b\u760d\u5883\u754c demarcation \u304c\u660e\u77ad\u3067\u6d78\u6f64\u50cf\u3092\u793a\u3055\u306a\u3044\u306e\u304c\u7279\u5fb4\u3067\u3059<\/li>\n<li>\u534a\u6570\u4ee5\u4e0a\u306b\u816b\u760d\u5185\u306e\u3046\u80de\u304c\u307f\u3089\u308c\uff0cmulticystic bubbly appearance\u3068\u547c\u3070\u308c\u307e\u3059<\/li>\n<li>\u816b\u760d\u5468\u8fba\u6d6e\u816b\u306e\u7a0b\u5ea6\u306f\u3055\u307e\u3056\u307e\u3067\u3059<\/li>\n<li>\u816b\u760d\u5468\u56f2\u304c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5f37\u304f\u5897\u5f37\u3055\u307e\u3059\u304c\uff0cheterogenous enhancement\u3067\u3059<\/li>\n<li>\u307e\u308c\u306b\uff0c\u816b\u760d\u5185\u51fa\u8840\u306b\u3088\u308a\u306e\u3046\u80de\u5185\u306b\u4e8c\u30dc\u30fc fluid-fluid level\u304c\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>\u8133\u5ba4\u5185\u306b\u7a81\u51fa\u3059\u308b\u3088\u3046\u306b\u5897\u5927\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u786c\u819c\u306b\u63a5\u3057\u6d78\u6f64\u3059\u308b\u3082\u306e\u3067\u306f dural tails\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\uff0c\u306e\u3046\u80de\u6027\u9ac4\u819c\u816b\u3068\u898b\u9593\u9055\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-20275 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-550x552.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-768x771.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast-1530x1536.jpg 1530w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/astroblast.jpg 1666w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u5883\u754c\u660e\u77ad\u306a\u816b\u760d\u3067\uff0c\u816b\u760d\u5185\u306b\u306e\u3046\u80de\u5f62\u6210\u3057\uff0c\u816b\u760d\u5b9f\u8cea\u306f\u5f37\u304f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u6df1\u90e8\u3067\u3059\u304c\uff0c\u8133\u8868\u767a\u751f\u306e\u3082\u306e\u306e\u65b9\u304c\u591a\u3044\u3067\u3059\u3002\u4ed6\u306e\u5c0f\u5150\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u3068\u753b\u50cf\u3067\u306f\u9451\u5225\u3067\u304d\u307e\u305b\u3093\u3002\u9000\u5f62\u6210\u6027\u4e0a\u8863\u816b\u3084\u65e7\u6765\u306ePNET\u3068\u547c\u79f0\u3055\u308c\u305f\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u3068\u306e\u753b\u50cf\u985e\u4f3c\u6027\u306f\u5f37\u3044\u3067\u3059\u3002<\/p>\n<h4>\u6cbb\u7642<\/h4>\n<ul>\n<li>\u624b\u8853\u6458\u51fa\u306e\u307f\u304c\u6cbb\u7642\u6cd5\u3067\u3059<\/li>\n<li>\u75c5\u7406\u5b66\u7684\u306b\u60aa\u6027\u5ea6\u304c\u5f37\u3044astroblastoma\u3067\u3082\uff0c\u624b\u8853\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\u9577\u671f\u4e88\u5f8c\u304c\u826f\u3044\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306f\u4e0d\u660e\u3067\u3059<\/li>\n<\/ul>\n<h4>\u4e88\u5f8c<\/h4>\n<ul>\n<li>2017\u5e74\u306eWHO\u5206\u985e\u3067\u306f\uff0c\u75c7\u4f8b\u306b\u3088\u3063\u3066\u4e88\u5f8c\u304c\u3055\u307e\u3056\u307e\u3067\u60aa\u6027\u5ea6\u306b\u95a2\u3059\u308b\u30b0\u30ec\u30fc\u30c9\u304c\u6c7a\u3081\u3089\u308c\u306a\u3044\u3068\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u3057\u304b\u3057\uff0c\u4e88\u5f8c\u304c\u826f\u3044\u3082\u306e\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>Sughrue\u3089\u306e\u6587\u732e\u4e0a\u306e116\u4f8b\u306ereview\u306b\u3088\u308c\u3070\uff0c5\u5e74\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408 5-year PFS\u306f\uff0c\u5168\u6458\u51fa gross total resection\u306783\uff05\uff0c\u90e8\u5206\u6458\u51fa subtotal resection\u306755%\u3067\u3059<\/li>\n<li>2021\u5e74WHO\u5206\u985e\u3067\u306f\uff0c<em>MN-1<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u3068\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n<h4>\u75c5\u7406<\/h4>\n<ul>\n<li>\u4e2d\u5fc3\u8840\u7ba1\u306e\u5468\u56f2\u306eastroblastic pseudorosettes \u304c\u7279\u5fb4\u7684\u3067\u3059<\/li>\n<li>\u3053\u306e\u69cb\u9020\u3092\u6709\u3057\u306a\u3044\u3082\u306e\u306fastroblastoma\u3068\u547c\u3073\u307e\u305b\u3093<\/li>\n<li>\u4e0a\u8863\u816b\u306b\u8fd1\u4f3c\u3059\u308b\u521d\u898b\u306a\u306e\u3067\u9451\u5225\u306f\u3068\u3066\u3082\u614e\u91cd\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>vimentin, S-100, GFAP\u304c\u5f37\u967d\u6027\u3067\u3059<\/li>\n<li>perivascular-hialinization\u3082\u7279\u5fb4\u3068\u3044\u3048\u307e\u3059<\/li>\n<li>\u661f\u7d30\u80de\u816b\u3084\u4e0a\u8863\u816b\u3092astroblastoma\u3068\u8a3a\u65ad\u3059\u308b\u3053\u3068\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u75c5\u7406\u8a3a\u65ad\u3067\u30b0\u30ec\u30fc\u30c9\u306f\u3064\u3051\u3089\u308c\u306a\u3044\u3068WHO\u306f\u5b9a\u7fa9\u3057\u3066\u3044\u307e\u3059<\/li>\n<li>\u3067\u3082\uff0c\u6587\u732e\u4e0a\u306f\uff0c\u9ad8\u5206\u5316\u578b well-differentiated \u3068\u9000\u5f62\u6210\u6027\u304c\u3042\u308b\u60aa\u6027\u578b malignant (anaplastic) \u306b\u5206\u3051\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u3082\u306e\u3067\u306f\uff0c\u9ad8\u3044\u5206\u88c2\u80fd MIB\u306e\u9ad8\u5024\uff0c\u9ad8\u3044\u7d30\u80de\u5bc6\u5ea6\uff0c\u6838\u7570\u578b\u6027\uff0c\u8840\u7ba1\u5185\u76ae\u5897\u751f\uff0c\u7d22\u72b6\u58ca\u6b7b\u306a\u3069\u304c\u307f\u3089\u308c\u307e\u3059<\/li>\n<\/ul>\n<h5>\u6587\u732e<\/h5>\n<ul>\n<li>Bell JW, et al.: Neuroradiologic characteristics of astroblastoma.\u00a0Neuroradiology. 49:203-209, 2007<\/li>\n<li>Sughrue ME, et al.: Clinical features and post-surgical outcome of patients with astroblastoma. J Clin Neurosci 18: 750-754, 2011<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30a2\u30b9\u30c8\u30ed\u30d6\u30e9\u30b9\u30c8\u30fc\u30de\u00a0WHO \u30b0\u30ec\u30fc\u30c9\u4e0d\u660e \u30a2\u30b9\u30c8\u30ed\u30d6\u30e9\u30b9\u30c8\u30fc\u30de\u3068\u547c\u3070\u308c\u308b\u306e\u304c\u666e\u901a\u3067\u3059 \u3068\u3066\u3082\u307e\u308c\u306a\u816b\u760d\u3067\uff0c\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u3042\u307e\u308a\u306a\u3044\u306e\u3067\uff0c\u6cbb\u7642\u6cd5\u3084\u4e88\u5f8c\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u305b\u3093 \u82e5\u3044\u6210\u4eba\u3068\u5b50\u3069\u3082\u306b\u307f\u3089\u308c\u307e\u3059 \u5973\u6027\u306b\u591a\u3044\u816b\u760d\u3067\u3059 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