{"id":191,"date":"2012-04-19T02:45:30","date_gmt":"2012-04-18T17:45:30","guid":{"rendered":"\/sawamura\/wp\/?p=191"},"modified":"2020-09-08T08:46:50","modified_gmt":"2020-09-07T23:46:50","slug":"neurocognition","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/pediattumor\/neurocognition\/","title":{"rendered":"\u5c0f\u5150\u306e\u8a8d\u77e5\u6a5f\u80fd\uff08\u77e5\u80fd\uff09 neurocognition"},"content":{"rendered":"
\n
\u6cbb\u7642\u304c\u6210\u529f\u3057\u3066\u751f\u304d\u6b8b\u3063\u305f\u767d\u8840\u75c5\u306e\u3053\u3069\u3082\u305f\u3061\u3068\u306e\u5927\u304d\u306a\u9055\u3044\u306f\uff0c\u8133\u816b\u760d\u306e\u3053\u3069\u3082\u306b\u91cd\u3044\u5f8c\u907a\u75c7\u304c\u591a\u3044\u3053\u3068\u3067\u3059<\/h5>\n
\u306a\u304b\u3067\u3082\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3 cognitive dysfunction\u304c\u554f\u984c\u3068\u306a\u308a\u307e\u3059
\n\u9ad8\u6b21\u8133\u6a5f\u80fd\u969c\u5bb3\uff0c\u5b66\u7fd2\u969c\u5bb3\uff0c\u6ce8\u610f\u6b20\u9665\u969c\u5bb3\u3068\u3082\u8868\u73fe\u3055\u308c\u307e\u3059<\/h5>\n

\u5b50\u4f9b\u306e\u8133\u7d44\u7e54\u306e\u767a\u9054<\/h4>\n

\u795e\u7d4c\u7d30\u80de\u306e\u767a\u9054\u306f\uff14\u6b73\u304f\u3089\u3044\u307e\u3067<\/span><\/strong>\uff1a\u3000100\u5104\u500b\u304f\u3089\u3044\u306e\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306f\u598a\u5a20\u5f8c\u671f\u306b\u306f\u305d\u308d\u3063\u3066\u3044\u307e\u3059\u3002\u751f\u307e\u308c\u3066\u304b\u3089\uff14\u6b73\u304f\u3089\u3044\u307e\u3067\u306b\u7070\u767d\u8cea\u306e\u4f53\u7a4d\u304c\u5927\u304d\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\uff0c\u7070\u767d\u8cea\u306b\u3042\u308b\u795e\u7d4c\u7d30\u80de\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\uff09\u306e\u4f53\u7a4d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\uff0c\u6a39\u72b6\u7a81\u8d77\u306e\u5206\u679d (dendric arbolization)\u304c\u751f\u3058\u3066\uff0c\u65b0\u3057\u3044\u30b7\u30ca\u30d7\u30b9\u304c\u3067\u304d\u308b\u304b\u3089\u3067\u3059\u3002\u5e73\u305f\u304f\u3044\u3046\u3068\uff0c\u795e\u7d4c\u7d30\u80de\u306e\u9593\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304c\u5f62\u6210\u3055\u308c\u3066\u5f35\u308a\u3081\u3050\u3055\u308c\u308b\u5927\u5207\u306a\u6642\u671f\u306a\u306e\u3067\u3059\u3002\u305d\u306e\u5f8c\u306b\uff0c\u4e0d\u8981\u306a\u795e\u7d4c\u7d30\u80de\u304c\u6b7b\u3093\u3067\u3044\u3063\u3066\u7070\u767d\u8cea\u306f\u5c11\u3057\u5c0f\u3055\u304f\u306a\u308a\u7121\u99c4\u306e\u306a\u3044\u8133\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u304c\u5b8c\u6210\u3055\u308c\u307e\u3059\u3002\u7cbe\u795e\u767a\u9054\u9045\u5ef6\u306e\u3053\u3069\u3082\u3067\u8133\u306e\u5bb9\u7a4d\u304c\u3068\u3066\u3082\u5927\u304d\u3044\u5b50\u304c\u3044\u307e\u3059\u304c\uff0c\u3053\u306e\u904e\u7a0b\u304c\u3046\u307e\u304f\u884c\u304b\u306a\u304b\u3063\u305f\u306e\u3060\u3068\u60f3\u50cf\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u6642\u671f\u306b\u8133\u795e\u7d4c\u7d30\u80de\u306b\u6bd2\u6027\u306e\u3042\u308b\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308c\u3070\uff0c\u795e\u7d4c\u7d30\u80de\u305d\u306e\u3082\u306e\u306e\u6210\u9577\u304c\u59a8\u3052\u3089\u308c\u307e\u3059\u3002
\n\u9ac4\u9798\u306e\u767a\u9054\u306f20\u6b73\u304f\u3089\u3044\u307e\u3067<\/span><\/strong>\uff1a\u3000\u795e\u7d4c\u7d30\u80de\u306e\u9593\u3092\u3064\u306a\u3050\u914d\u7dda\u306e\u3088\u3046\u306a\u3082\u306e\u3092\u8ef8\u7d22 (axon) \u3068\u3044\u3044\u307e\u3059\u3002\u8133\u795e\u7d4c\u7d30\u80de\u306f\u3082\u306e\u3059\u3054\u304f\u8907\u96d1\u306a\u8ef8\u7d22\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3067\u3064\u306a\u304c\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8ef8\u7d22\u3092\u5b88\u3063\u3066\u50cd\u304d\u3092\u52a9\u3051\u308b\u305f\u3081\u306b\u8ef8\u7d22\u306e\u5468\u308a\u306f\u9ac4\u9798\uff08\u30df\u30a8\u30ea\u30f3\uff09\u3068\u3044\u3046\u9798\uff08\u819c\uff09\u3067\u4fdd\u8b77\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5bb6\u5ead\u306b\u3042\u308b\u96fb\u7dda\u3068\u540c\u3058\u69cb\u9020\u3067\u3059\u3002 \u3053\u306e\u9ac4\u9798\u306f\u80ce\u5150\u306e\u6642\u304b\u308920\u6b73\u304f\u3089\u3044\u307e\u3067\u5897\u3048\u3066\u3044\u3063\u3066\uff08\u767d\u8cea\u306e\u5897\u5927\uff09\uff0c\u6210\u4eba\u306b\u306a\u3063\u3066\u304b\u3089\u5168\u90e8\u306e\u8ef8\u7d22\u304c\u9ac4\u9798\u3067\u8986\u308f\u308c\u307e\u3059\u3002\u9ac4\u9798\u306f\u8133\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u901f\u5ea6\u3092\u3042\u3052\u3066\u52b9\u7387\u3092\u5897\u3057\u307e\u3059\u3002\u9ac4\u9798\u306e\u767a\u9054\u306f\uff0c\u3053\u3069\u3082\u304c\u5b66\u7fd2\u3092\u3057\u3066\u9ad8\u5ea6\u306a\u8133\u306e\u80fd\u529b\uff08\u9ad8\u6b21\u8133\u6a5f\u80fd\uff09\u3084\u77e5\u80fd\uff08\u9ad8\u3044\u8a8d\u77e5\u80fd\u529b\uff09\u3092\u7372\u5f97\u3059\u308b\u306e\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c20\u6b73\u4ee5\u4e0b\u306e\u3053\u3069\u3082\u306e\u8133\u306f\uff0c\u9ac4\u9798\u5f62\u6210\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3042\u308b\u3044\u306f\u9ac4\u9798\u3092\u58ca\u3059\u795e\u7d4c\u6bd2\uff08\u653e\u5c04\u7dda\u3084\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306a\u3069\u306e\u5236\u304c\u3093\u5264<\/strong><\/span>\uff09\u306b\u3068\u3066\u3082\u5f31\u3044\u306e\u3067\u3059\u3002\u969c\u5bb3\u3092\u53d7\u3051\u305f\u8133\u306e\u767d\u8cea\u306e\u5bb9\u7a4d\u304c\u6e1b\u308b\u306e\u306f\u9ac4\u9798\u5f62\u6210\u304c\u59a8\u3052\u3089\u308c\u308b\u304b\u3089\u3067\uff0c\u5b66\u7fd2\u7372\u5f97\u80fd\u529b\u306e\u4f4e\u4e0b\u3068\u8a8d\u77e5\u969c\u5bb3\u3092\u751f\u3058\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1aMoore III BD: Neurocognitive outcomes in survivors of childhood cacer. J Pediatr Psy 30, 2005 \u3092\u8981\u7d04\u3057\u3066\u89e3\u8aac\u3057\u305f\u3082\u306e\u3067\u3059<\/p>\n

\u5e74\u9f62\u3068\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\uff08\u7279\u306b\u624b\u8853\u3068\u5408\u4f75\u75c7\uff09<\/h4>\n

\u3088\u304f\u77e5\u3089\u308c\u305f\u3053\u3068\u3067\u3059\u304c\uff0c\u5c0f\u3055\u3044\u5b50\u4f9b\u307b\u3069\u816b\u760d\u3084\u6cbb\u7642\u306b\u3088\u3063\u3066\uff0c\u8a8d\u77e5\u6a5f\u80fd\u306e\u767a\u9054\u3092\u59a8\u3052\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3060\u3051\u3067\u306f\u306a\u304f\u69d8\u3005\u306a\u8981\u7d20\u304c\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u816b\u760d\u306e\u767a\u751f\u90e8\u4f4d\uff0c\u767a\u75c7\u6642\u306e\u610f\u8b58\u969c\u5bb3\uff0c\u624b\u8853\u306e\u65b9\u6cd5\u3068\u56de\u6570\uff0c\u5316\u5b66\u7642\u6cd5\uff0c\u6c34\u982d\u75c7\uff0c\u30b7\u30e3\u30f3\u30c8\u624b\u8853\uff0c\u9ac4\u819c\u708e\u306a\u3069\u306e\u5408\u4f75\u75c7\u306a\u3069\uff0c\u3069\u308c\u3092\u3068\u3063\u3066\u3082\u5e74\u9577\u5150\u3088\u308a\u5c0f\u3055\u306a\u3053\u3069\u3082\u306e\u65b9\u304c\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u3069\u3093\u306a\u6cbb\u7642\u306b\u3057\u3066\u3082\u5c0f\u3055\u3044\u5b50\u4f9b\u306e\u65b9\u304c\u96e3\u3057\u3044\u3057\uff0c\u3088\u308a\u614e\u91cd\u306b\u3057\u306a\u3044\u3068IQ\u306e\u4f4e\u4e0b\u3084\u8a8d\u77e5\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/span>
\n \u7279\u306b\uff0c<\/span>\u624b\u8853\u306e\u5f71\u97ff\u304c\u5927\u304d\u3044<\/span><\/strong>\u306e\u3067\u3059\u304c\uff0c\u5c0f\u3055\u3044\u5b50\u4f9b\u3067\u306f\u8a8d\u77e5\u6a5f\u80fd\u306e\u691c\u67fb\u304c\u3057\u306b\u304f\u3044\u3057\uff0c\u307e\u305f\u624b\u8853\u306e\u76f4\u5f8c\u306b\u306f\u300c\u9ebb\u75fa\u3082\u306a\u3044\u3057\u5143\u6c17\u305d\u3046\u3060\u306d\u300f\u3068\u3044\u3046\u8a55\u4fa1\u3067\u904e\u304e\u3066\u3057\u307e\u3044\u307e\u3059\u306e\u3067\uff0c\u4f55\u5e74\u3082\u305f\u3063\u3066\u304b\u3089\u8a8d\u77e5\u6a5f\u80fd\u767a\u9054\u306e\u9045\u308c\u304c\u76ee\u7acb\u3063\u3066\u304d\u3066\u3082\uff0c\u624b\u8853\u306e\u305f\u3081\u3060\u3068\u306f\u8ab0\u3082\u601d\u308f\u306a\u3044\u306e\u3067\u3059\u3002\u3060\u3044\u305f\u3044<\/span>\u307b\u3068\u3093\u3069\u306e\u8133\u5916\u79d1\u533b\u304c\u3053\u306e\u4e8b\u5b9f\u3092\u77e5\u308a\u307e\u305b\u3093<\/span><\/strong>\u3002<\/p>\n

\u5c0f\u8133\u3068\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u30fb\u5f8c\u982d\u7aa9\u75c7\u5019\u7fa4<\/h4>\n

\u5c0f\u8133\u306f\u904b\u52d5\u306e\u5354\u8abf\u6027\u3092\u4fdd\u3064\u50cd\u304d\u3092\u3059\u308b\u306e\u3067\uff0c\u816b\u760d\u3084\u5916\u79d1\u624b\u8853\u3067\u5c0f\u8133\u3092\u640d\u50b7\u3059\u308b\u3068\u904b\u52d5\u5931\u8abf\u3060\u3051\u304c\u751f\u3058\u308b\u3068\u9577\u3044\u9593\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\uff0c\u5c0f\u8133\u6a5f\u80fd\u306e\u969c\u5bb3\u304c\u8a8d\u77e5\u969c\u5bb3 (neurocognitive decline, deficit of higher order cognitive skills) \u3092\u751f\u3058\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u751f\u7406\u5b66\u7684\u306b\u306f\u5c0f\u8133\u3068\u524d\u982d\u8449\u306e\u9593\u306e\u60c5\u5831\u51e6\u7406\u7d4c\u8def\u304c\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002<\/span>\u5c0f\u8133\u306b\u4f9d\u5b58\u3059\u308b\u6ce8\u610f\u529b\u3068\u60c5\u5831\u51e6\u7406\u901f\u5ea6\u306e<\/span>\u4f4e\u4e0b<\/span><\/strong>\u304c\u751f\u3058\u308b\u305f\u3081\u3067\u3059\u3002<\/span><\/p>\n

\u8853\u5f8c\u306e\u4e00\u6642\u7684\u306a<\/span>\u5c0f\u8133\u6027\u7121\u8a00\u75c7<\/span><\/strong> (cerebellar mutism) \u3060\u3051\u3067\u306f\u306a\u304f\u3066\uff0c\u6ce8\u610f\u529b\uff0c\u8a18\u61b6\uff0c\u51e6\u7406\u901f\u5ea6\uff0c\u60c5\u7dd2\u969c\u5bb3\u3001\u8996\u899a\u69cb\u6210 (visual constructive copying)\u306a\u3069\u306b\u5f71\u97ff\u304c\u3042\u308b\u3068\u3055\u308c\u307e\u3059\u304c\uff0c\u5168\u822c\u7684\u306a\u77e5\u80fd (full scale IQ) \u306b\u306f\u5927\u304d\u306a\u5f71\u97ff\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u9ac4\u82bd\u816b\uff0c\u4e0a\u8863\u816b\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306a\u3069\u306e\u30c6\u30f3\u30c8\u4e0b\u816b\u760d\u3067\u5f8c\u982d\u7aa9\u75c7\u5019\u7fa4 (<\/span>posterior fossa syndrome<\/span><\/strong>) \u3042\u308b\u3044\u306f\u5c0f\u8133\u8a8d\u77e5\u30fb\u60c5\u7dd2\u75c7\u5019\u7fa4 (<\/span>cerebellar cognitive affective syndrome: CCAS<\/span><\/strong>) \u3068\u3057\u3066\u77e5\u3089\u308c\u307e\u3059\u3002\u539f\u56e0\u3068\u3057\u3066\u306f\u3001\u624b\u8853\u6642\u306b\u5c0f\u8133\u4e2d\u90e8\u3001\u5c0f\u8133\u6df1\u90e8\u767d\u8cea\u3001\u6b6f\u72b6\u6838\u306e\u640d\u50b7\u304c\u5927\u304d\u3044\u305f\u3081\u306b\u751f\u3058\u307e\u3059\u304b\u3089\u3001\u7b2c4\u8133\u5ba4\u816b\u760d\u3092\u6458\u51fa\u3059\u308b\u3068\u304d\u306b\u5c0f\u8133\u4e2d\u90e8\u5207\u958b\u3092\u6700\u5c0f\u9650\u306b\u3059\u308b\u3053\u3068\u3067\u907f\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5f8c\u907a\u75c7\u3067\u3059\u3002\u3082\u3061\u308d\u3093\u5c0f\u8133\u8133\u5e79\u90e8\u3078\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3082\u5c0f\u8133\u6a5f\u80fd\u4f4e\u4e0b\u3092\u62db\u304f\u306e\u3067\u540c\u69d8\u306e\u75c7\u72b6\u304c\u51fa\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n

\u6ce8\u610f\u6b20\u9665\u969c\u5bb3\u30fb\u591a\u52d5\u6027\u969c\u5bb3 ADHD\u306e\u5408\u4f75<\/h4>\n

\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u5b66\u7fd2\u3084\u793e\u4f1a\u751f\u6d3b\u306b\u56f0\u96e3\u3092\u751f\u3058\u307e\u3059\u3002\u3067\u3082\u3053\u308c\u306f\u77e5\u80fd\u3068\u3044\u3046\u5074\u9762\u3060\u3051\u306e\u554f\u984c\u3067\u306f\u308a\u307e\u305b\u3093\u3002\u60c5\u7dd2\u884c\u52d5\u306b\u3082\u969c\u5bb3\u304c\u3042\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u8133\u816b\u760d\u306e\u9577\u671f\u751f\u5b58\u8005\u306b\u306f\uff0cADHD\uff08\u6ce8\u610f\u6b20\u9665\u30fb\u591a\u52d5\u6027\u969c\u5bb3\uff09\u306e\u5b50\u3069\u3082\u9054\u306b\u5fdc\u7528\u3055\u308c\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3057\u3070\u3057\u3070\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u6ce8\u610f\u969c\u5bb3\u306e\u3042\u308b\u8133\u816b\u760d\u751f\u5b58\u8005\u306e4\u4eba\u306b1\u4eba\u304cAD\/HD\u3068\u540c\u3058\u75c7\u5019\u3092\u5448\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u6ce8\u610f\u6b20\u9665\u969c\u5bb3\u3092\u6709\u3059\u308b\u5b50\u3069\u3082\u306f\uff0c\u4ed6\u306e\u8133\u816b\u760d\u751f\u5b58\u8005\u3088\u308a\u3082\u3055\u3089\u306b\u5b66\u7fd2\u304c\u56f0\u96e3\u306a\u72b6\u6cc1\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002
\nHardy KK: Attention-mediated\u00a0neurocognitive\u00a0profiles\u00a0in\u00a0survivors\u00a0of pediatric brain tumors: comparison to children with neurodevelopment ADHD.\u00a0Neuro Oncol.\u00a02018<\/p>\n

\u5316\u5b66\u7642\u6cd5\u3068\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3<\/h4>\n

\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u3042\u3068\u3067\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u3092\u4f7f\u3063\u305f\u5316\u5b66\u7642\u6cd5\u3092\u3059\u308b\u3068\uff0c\u3072\u3069\u3044\u4e9c\u6025\u6027\u306e<\/span>\u767d\u8cea\u8133\u75c7<\/span><\/strong> (subacute leukoencephalopathy) \u304c\u751f\u3058\u3066\u9ad8\u5ea6\u306e\u8a8d\u77e5\u969c\u5bb3\u306b\u306a\u308b\u3053\u3068\u306f\uff0c40\u5e74\u4ee5\u4e0a\u524d\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3067\u3059\u304b\u3089\uff0c\u8133\u816b\u760d\u306b\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\uff08\u9759\u6ce8\uff0c\u9ac4\u6ce8\uff09 \u3092\u4f7f\u3046\u5834\u5408\u306b\u306f\uff0c\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u3092\u4f7f\u7528\u3057\u3066\u304b\u3089\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002 \u305d\u308c\u3067\u3082\u6295\u4e0e\u91cf\u306b\u3088\u3063\u3066\u306f\u767d\u8cea\u8133\u75c7\u306f\u8d77\u3053\u308a\u307e\u3059\u3002<\/span><\/p>\n

Iuvone\u3068\u3044\u3046\u30ed\u30fc\u30de\u306e\u5c0f\u5150\u795e\u7d4c\u79d1\u533b\u304c\u9577\u671f\u751f\u5b58\u3057\u305f\u6025\u6027\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u767d\u8840\u75c5 (ALL) \u306e\u5b50\u4f9b\u305f\u3061\u3092\u8abf\u67fb\u3057\u305f\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u767d\u8840\u75c5\u306f\u8133\uff08\u9ac4\u8154\uff09\u306b\u8ee2\u79fb\u3057\u3084\u3059\u3044\u306e\u3067\uff0c\u5168\u8133\u810a\u9ac4\u7167\u5c0418-24\u30b0\u30ec\u30a4\u3068\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306e\u9ac4\u6db2\u5185\u6295\u4e0e (IT) \u3067\u6cbb\u7642\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/span>\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306e\u9ac4\u6ce8<\/span><\/strong>\u306e\u56de\u6570\u304c\uff0c\u8133\u306e\u77f3\u7070\u5316\uff08\u767d\u8cea\u5909\u6027\uff09\u3068\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306b\u6df1\u3044\u95a2\u4fc2\u304c\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u4e00\u65b9\u4e88\u60f3\u306b\u53cd\u3057\u3066\uff0c18\u30b0\u30ec\u30a4\u306824\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u91cf\u3067\u306f\u8a8d\u77e5\u6a5f\u80fd\u306b\u5dee\u304c\u306a\u304b\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306b\u95a2\u3057\u3066\u306f\uff0c\u540c\u69d8\u306bALL\u3067\u30d7\u30ec\u30c9\u30cb\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff0c\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\uff0c\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306e\u5316\u5b66\u7642\u6cd5\u3060\u3051\u3067\u6cbb\u7642\u3055\u308c\u305f\u3053\u3069\u3082\u306b\u8133\u767d\u8cea\u306e\u7570\u5e38\u304c\u898b\u3089\u308c\u305f\u3068\u3044\u3046\u5831\u544a\u306a\u3069\u3044\u308d\u3044\u308d\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u4e00\u822c\u7684\u306b\u306f\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u5358\u72ec\u3067\u306f\u554f\u984c\u306f\u5c0f\u3055\u304f\uff0c\u8133\u7167\u5c04\u3068\u4f75\u7528\u3055\u308c\u305f\u6642\u306b\u969c\u5bb3\u304c\u5927\u304d\u304f\u306a\u308b\u3068\u8003\u3048\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3002<\/span>
\n Iuvone L et al.: Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for atute lymphoblastic leukemia. Cancer 95: 2562-2570, 2003<\/span><\/p>\n

\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3092\u9632\u3050\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u306f\uff0c\u767a\u9054\u904e\u7a0b\u306b\u3042\u308b\u9ac4\u9798\u306b\u6bd2\u6027\u3092\u6709\u3059\u308bMTX \u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306e\u9ac4\u6ce8\u3092\u3057\u306a\u3044\u3088\u3046\u306b\u52aa\u3081\u307e\u3059\u3002\u8133\u816b\u760d\u306e\u5b50\u3069\u3082\u9054\u306f\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3067\u82e6\u3057\u3080\u3053\u3068\u306f\u8ab0\u3067\u3082\u77e5\u3063\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u304b\u3089\uff0c\u53ef\u80fd\u3067\u3042\u308c\u3070\u305d\u308c\u3092\u751f\u3058\u308b\u304b\u3082\u3057\u308c\u306a\u3044MTX\u306f\u6975\u529b\u907f\u3051\u3066\u6cbb\u7642\u3092\u884c\u3046\u3068\u3044\u3046\u3053\u3068\u306f\u5f53\u305f\u308a\u524d\u306e\u8ad6\u7406\u3067\u3059\u3002<\/span><\/p>\n

\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3<\/h4>\n

\u653e\u5c04\u7dda\u6cbb\u7642\u76f4\u5f8c\u3084\uff13\u30f6\u6708\u5f8c\u304f\u3089\u3044\u306b\u6025\u6027\u3042\u308b\u3044\u306f\u4e9c\u6025\u6027\u653e\u5c04\u7dda\u8133\u969c\u5bb3\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u539f\u56e0\u306f\uff0c\u5168\u8133\u7167\u5c04\u306e\u7dda\u91cf\uff0c\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\uff0c\u30a4\u30d5\u30a9\u30de\u30a4\u30c9\uff0c\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\uff0c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u306a\u3069\u306e\u85ac\u5264\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u7d44\u307f\u5408\u308f\u305b\u306a\u3069\u3067\u3059\u3002\u4e00\u6642\u7684\u306a\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u9ad8\u9f62\u8005\u3067\u306f\u56de\u5fa9\u3057\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u5e7c\u5150\u3067\u3082\u4e9c\u6025\u6027\u306e\u653e\u5c04\u7dda\u8133\u969c\u5bb3\u306b\u3088\u308b\u9ad8\u5ea6\u306e\u8133\u840e\u7e2e\u304c\u56de\u5fa9\u3057\u306a\u3044\u3053\u3068\u304c\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3082\u3063\u3068\u3082\u554f\u984c\u3067\u9ad8\u983b\u5ea6\u306b\u898b\u3089\u308c\u308b\u306e\u304c\uff0c\u9045\u767a\u6027\u306e\u653e\u5c04\u7dda\u8133\u969c\u5bb3<\/span><\/strong>\u3067\u3059\u3002\u3053\u308c\u306f\uff0c\u4f55\u5e74\u3082\u304b\u304b\u3063\u3066\u3086\u3063\u304f\u308a\u60aa\u5316\u3059\u308b\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3067\u3059\u3002\u3053\u308c\u306f\u4e0a\u306e\u65b9\u306b\u66f8\u3044\u305f\u8133\u7d44\u7e54\u306e\u767a\u9054\uff0c\u7279\u306b\u767d\u8cea\u306e\u9ac4\u9798\u5f62\u6210\u3068\u6df1\u304f\u95a2\u4fc2\u3059\u308b\u3082\u306e\u3067\uff0c\u5c0f\u5150\u8133\u816b\u760d\u6cbb\u7642\u306b\u304a\u3051\u308b\u6700\u3082\u5927\u304d\u306a\u554f\u984c<\/span><\/strong>\u3067\u3059\u3002\u4f7f\u3046\u653e\u5c04\u7dda\u91cf (dose)\uff0c\u3042\u3066\u308b\u5834\u6240 (region)\uff0c\u3042\u3066\u308b\u5e83\u3055\uff08field volume)\uff0c\u60a3\u5150\u306e\u5e74\u9f62 (age) \u3067\u969c\u5bb3\u306e\u91cd\u3055\u304c\u6c7a\u307e\u308a\u307e\u3059\u3002\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3068\u3044\u3063\u3066\u3082\uff0c\u8a00\u8449\u306e\u767a\u9054 (verval IQ) \u306a\u3069\u306f\u6bd4\u8f03\u7684\u826f\u3044\u306e\u3067\u3059\u304c\uff0c\u65b0\u3057\u3044\u3053\u3068\u3092\u5b66\u3076\u3053\u3068\u304c\u4e0d\u5f97\u610f\uff08\u5b66\u7fd2\u7372\u5f97\u80fd\u529b\u306e\u4f4e\u4e0b\uff09\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002\u7167\u5c04\u3092\u53d7\u3051\u305f\u5b50\u3069\u3082\u3067\u306f\u524d\u982d\u8449\u3068\u5074\u982d\u8449\u306e\u4f53\u7a4d\u304c\u5897\u52a0\u3059\u308b\u306e\u304c\u9045\u308c\uff0c\u540c\u6642\u306b\u8a9e\u5f59\u00a0vocabulary \u306e\u767a\u9054\u304c\u9045\u308c\u307e\u3059\u3002<\/p>\n

\u3067\u304d\u308b\u3053\u3068\u306a\u3089\u3070\uff0c\uff14\u6b73\u3092\u3053\u3048\u308b\u307e\u3067\u306f\u5168\u8133\u7167\u5c04\u3092\u3057\u306a\u3044\u65b9\u304c\u3044\u3044\u306e\u3067\u3059\u304c\uff0c\uff13\u6b73\u3092\u8d85\u3048\u3066\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u660e\u3089\u304b\u306b\u751f\u5b58\u5272\u5408\u3068\u3044\u3046\u610f\u5473\u3067\u306e\u6cbb\u7642\u6210\u7e3e\u3092\u826f\u304f\u3059\u308b\u3068\u4e88\u6e2c\u3067\u304d\u308c\u3070\uff0c\u5168\u8133\u7167\u5c04\u306f\u9078\u629e\u3055\u308c\u307e\u3059\u3002\u5927\u8133\u816b\u760d\u306e\u5b50\u4f9b\u306e\u65b9\u304c\u5c0f\u8133\u306e\u816b\u760d\u3088\u308a\u3082\uff0c\u8133\u7167\u5c04\u3067\u3088\u308a\u5927\u304d\u306a\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n

\u816b\u760d\u3092\u6cbb\u7652\u306b\u5c0e\u304f\u305f\u3081\u306b\u4e0d\u53ef\u907f\u3068\u8003\u3048\u3089\u308c\u308b\u5168\u8133\u7167\u5c04\u306e\u7dda\u91cf\u306b\u95a2\u3057\u3066\uff0c\u73fe\u6642\u70b9\u3067\u6b21\u306e\u3088\u3046\u306a\u539f\u5247\u304c\u3042\u308a\u307e\u3059\u3002\u3082\u3061\u308d\u3093\uff0c\u8ffd\u52a0\u306e\u5c40\u6240\u7167\u5c04\u306f\uff0c\u500b\u3005\u306e\u75c7\u4f8b\u306b\u3088\u3063\u3066\u304b\u306a\u308a\u5909\u308f\u308a\u307e\u3059\u3057\uff0c\u4f8b\u5916\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

0\u6b73\u304b\u30893\u6b73 \u00a0 \u00a0 \u00a0 \u00a0\u884c\u308f\u306a\u3044
\n4\u6b73\u304b\u30896\u6b73\u307e\u3067 \u00a0 \u00a018\u30b0\u30ec\u30a4\/10\u5206\u5272
\n6\u6b73\u4ee5\u4e0a \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 23.4\u30b0\u30ec\u30a4\/13\u5206\u5272\uff0c25.2\u30b0\u30ec\u30a4\/14\u5206\u5272
\n\u64ad\u7a2e\u306e\u3042\u308b\u4f8b \u00a0 \u00a0 \u00a0\u8a8d\u77e5\u6a5f\u80fd\u4e88\u5f8c\u3088\u308a\u6551\u547d\u76ee\u7684\u3068\u306a\u308a\u307e\u3059<\/h5>\n
\n

\u30e1\u30c8\u30db\u30eb\u30df\u30f3 metformin \u304c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e\u8a8d\u77e5\u6a5f\u80fd\u306e\u56de\u5fa9\u306b\u6709\u52b9\u304b\u3082\u3057\u308c\u306a\u3044<\/h4>\n

Ayoub R:\u00a0<\/span>Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin. Nat Med 2020
\n\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u7cfb\u306e2\u578b\u7cd6\u5c3f\u75c5\u306e\u7d4c\u53e3\u6cbb\u7642\u85ac\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e\u5c0f\u5150\u306e\u8a8d\u77e5\u6a5f\u80fd\u306e\u6539\u5584\u306b\u6709\u7528\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u5831\u544a\u3067\u3059\u3002\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f\uff0c\u795e\u7d4c\u524d\u99c6\u7d30\u80de neuronal precursor cells \u306e\u6210\u9577\u3092\u4fc3\u3059 neurogenesis\u3068\u3044\u3046\u4f5c\u7528\u3092\u6709\u3057\u3066\u3044\u308b\u304b\u3089\u3060\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5973\u5150\u306b\u304a\u3044\u3066\u52b9\u679c\u304c\u306f\u3063\u304d\u308a\u8a8d\u3081\u3089\u308c\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u982d\u84cb\u7167\u5c04\u3092\u53d7\u3051\u305f\u5c0f\u5150\u8133\u816b\u760d\u60a3\u800524\u4eba\u3067\u306epilot trial \u306a\u306e\u3067\uff0c\u4eca\u5f8c\u306e\u3088\u308a\u5927\u304d\u306a\u81e8\u5e8a\u8a66\u9a13\u3067\u8ffd\u8a66\u3055\u308c\u306a\u3044\u3068\u306a\u3093\u3068\u3082\u8a00\u3048\u306a\u3044\u3067\u3059\u3002<\/p>\n<\/div>\n

\u8133\u816b\u760d\u304c\u6cbb\u3063\u305f\u5b50\u4f9b\u305f\u3061\u306e\u8a8d\u77e5\u6a5f\u80fd<\/h4>\n

Brinkman TM, et al.: Long-Term Neurocognitive Functioning and Social Attainment in Adult Survivors of Pediatric CNS Tumors: Results From the St Jude Lifetime Cohort Study. J Clin Oncol 34:1358-67, 2016
\nSt. Jude\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002224\u4eba\u306e\u8133\u816b\u760d\u306e\u5b50\u3069\u3082\u305f\u3061\u304c\u6210\u4eba\u306b\u306a\u3063\u3066\u304b\u3089\uff0c\u8a8d\u77e5\u6a5f\u80fd\u691c\u67fb\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u6cbb\u7642\u5f8c\u4e2d\u592e\u5024\u306718\u5e74\u3067\u3059\u3002\u8133\u810a\u9ac4\u7167\u5c04\u3092\u3057\u3066\u3044\u308b\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u5834\u5408\u306b\u6bd4\u3079\u3066\uff0c1.5\u500d\u304b\u30893\u500d\u304f\u3089\u3044\u9ad8\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3066\u3093\u304b\u3093\u304c\u3042\u308b\u3068\u5b66\u6821\u3067\u306e\u6210\u7e3e\u304c\u60aa\u3044\uff0c\u6c34\u982d\u75c7\u3067\u30b7\u30e3\u30f3\u30c8\u3092\u53d7\u3051\u3066\u3044\u308b\u5b50\u4f9b\u306f\u77e5\u80fd\u6307\u6570\u304c\u4f4e\u3044\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u305f\u3068\u3048\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u306a\u304f\u3066\u3082\uff0c\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306e\u305f\u3081\u306b\uff0c\u6559\u80b2\u30ec\u30d9\u30eb\u304c\u4f4e\u3044\uff0c\u5c31\u8077\u3067\u304d\u306a\u3044\uff0c\u81ea\u7acb\u3057\u3066\u751f\u6d3b\u3067\u304d\u306a\u3044\u5b50\u4f9b\u304c\u591a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

\n

\u9ac4\u82bd\u816b\u306e\u751f\u5b58\u8005\u3092\u63f4\u52a9\u3059\u308b\uff0c\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u50be\u5411\u306f5\u5e74\u7d9a\u304f<\/strong><\/h4>\n

Sands SA: Helping survivors of medulloblastoma learn from what we learn. J Clin Oncol 31:3480-3482, 2013
\nPalmer SL, et al.: Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol 31: 3494-3500, 2013
\n3\u6b73\u304b\u308921\u6b73\uff0c\u4e2d\u592e\u50249.8\u969b\u306e\u9ac4\u82bd\u816b\u306e\u5b50\u3069\u3082126\u4eba\u304c\uff0c\u8133\u810a\u9ac4\u7167\u5c04\u3068\u5c40\u6240\u7167\u5c04\u3068\u5316\u5b66\u7642\u6cd5\u3067\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u9ad8\u30ea\u30b9\u30af\u7fa4\u306b\u306f\u8133\u810a\u9ac4\u7167\u5c0436\u30b0\u30ec\u30a4\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u82f1\u8a9e\u306a\u306e\u3067\u6b63\u78ba\u306b\u8a33\u305b\u307e\u305b\u3093\u304c\uff0c\u8a8d\u77e5\u6a5f\u80fd\u3092processing speed (PS), broad attention (BA), and working memory (WM)\u3067\u8ffd\u8de1\u8abf\u67fb\u3055\u308c\u307e\u3057\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\u5927\u5207\u306a\u3053\u3068\u306f\uff0c\u4f4e\u5e74\u9f62\u304c\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u3068\u306a\u308b\u3068\u3044\u3046\u5f53\u305f\u308a\u524d\u306e\u3053\u3068\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u4e3b\u306b\u7167\u5c04\u306e\u5f71\u97ff\u306a\u306e\u3067\u3059\u304c\uff0cPS\uff08\u30d1\u30fc\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u30fb\u30b9\u30c6\u30a4\u30bf\u30b9\uff0c\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\u306e\u30ec\u30d9\u30eb\uff09\u3068processing speed \u306f\uff15\u5e74\u3067\u6700\u4f4e\u30ec\u30d9\u30eb\u306b\u9054\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u6cbb\u7642\u304c\u7d42\u308f\u3063\u3066\u5b66\u6821\u306b\u623b\u3063\u3066\u3082\uff0c\u6570\u5e74\u9593\u306f\u6210\u7e3e\u304c\u843d\u3061\u3066\u3044\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u30af\u30e9\u30b9\u304b\u3089\u8131\u843d\u3059\u308b\u306e\u3067\u3059\u3002\u3053\u306e\u9593\u306e\u5b50\u3069\u3082\u305f\u3061\u306e\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u50be\u5411\u3078\u306e\u7406\u89e3\u304c\u5fc5\u7528\u3060\u3068\u89e3\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u4e21\u89aa\u3042\u308b\u3044\u306f\u751f\u5b58\u8005\u306e\u6559\u80b2\u3068\u30ea\u30cf\u30d3\u30ea\u306e\u62c5\u5f53\u3059\u308b\u4eba\u304c\uff0c\u8a3a\u65ad\u5f8c5\u5e74\u307e\u3067\u306fPS\u304c\u4f4e\u4e0b\u3057\u7d9a\u3051\u308b\u3068\u3044\u3046\u6307\u6a19\u3092\u308f\u304d\u307e\u3048\u3066\u5bfe\u5fdc\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002
\nPalmer\u306e\u8ad6\u6587\u3067\u306f\uff0c\u6cbb\u7642\u3092\u53d7\u3051\u305f318\u4eba\u306e\u9ac4\u82bd\u816b\u306e\u5b50\u3069\u3082\u306e\u3046\u306175\u4eba\u306bposterior fossa syndrome\u304c\u751f\u3058\u3066\u3044\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u5c0f\u8133\u6027\u7121\u8a00\u75c7\u304c\u5b9f\u306b25%\u306e\u5b50\u3069\u3082\u306b\u8d77\u3053\u3063\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u5f8c\u308d\u306e\u65b9\u306e2006\u5e74 Robertson\u306e\u8ad6\u6587\u306b\u308224%\u3068\u66f8\u304b\u308c\u3066\u3044\u308b\u306e\u3067\u9a5a\u304d\u3067\u3059\u30024\u4eba\u306b\uff11\u4eba\u306f\u5c0f\u8133\u866b\u90e8\u3092\u5927\u304d\u304f\u5207\u958b\u3057\u3066\u9ac4\u82bd\u816b\u304c\u6458\u51fa\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3042\u308b\u8208\u5473\u6df1\u3044speculation\u304c\u3042\u308a\uff0c\u3082\u3068\u3082\u3068\u77e5\u80fd\u306e\u9ad8\u3044\u5b50\u3069\u3082\u307b\u3069\u653e\u5c04\u7dda\u6bd2\u6027\u3092\u53d7\u3051\u3084\u3059\u304f\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u5272\u5408\u304c\u9ad8\u3044\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n<\/div>\n

\n

\u8a8d\u77e5\u969c\u5bb3\u306e\u6cbb\u7642\u3068\u5c06\u6765\u306e\u65b9\u5411<\/h4>\n

\"\"<\/a>\u3055\u307e\u3056\u307e\u306a\u30bf\u30a4\u30d7\u306e\u8a8d\u77e5\u969c\u5bb3\u304c\u751f\u3058\u307e\u3059\u306e\u3067\uff0c\u6cbb\u7642\u3068\u3044\u3063\u3066\u3082\u3068\u3066\u3082\u8907\u96d1\u3067\u3059\u3002\u307e\u305f\u969c\u5bb3\u306e\u7a0b\u5ea6\u3082\u8efd\u3044\u3082\u306e\u304b\u3089\u91cd\u5ea6\u306e\u3082\u306e\u307e\u3067\uff0c\u4e00\u5b9a\u306e\u50be\u5411\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5c0f\u5150\u306e\u767a\u9054\u306b\u8a73\u3057\u3044\u5c0f\u5150\u79d1\u306e\u5148\u751f\u306e\u8a55\u4fa1\u6307\u5c0e\u3068\u3068\u3082\u306b\uff0c\u5b66\u7fd2\u80fd\u529b\u306e\u4f4e\u4e0b\u306a\u3069\u306b\u5bfe\u5fdc\u3059\u308b\u305f\u3081\u306b\u306f\u7279\u5225\u306a\u5b66\u6821\u3084\u6307\u5c0e\u304c\u5fc5\u8981\u3067\u3059\u3002\u4e0d\u767b\u6821\u306b\u306a\u308b\u3053\u3069\u3082\u3084\u81ea\u9589\u75c7\u3082\u591a\u3044\u3067\u3059\u3002\u9577\u671f\u751f\u5b58\u3057\u3066ADHD\uff08\u6ce8\u610f\u6b20\u9665\u591a\u52d5\u6027\u969c\u5bb3\uff09\u306b\u306a\u3063\u305f\u8133\u816b\u760d\u306e\u3053\u3069\u3082\u306b\u30ea\u30bf\u30ea\u30f3\u306a\u3069\u306e\u85ac\u5264\u304c\u6709\u52b9\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u8a8d\u77e5\u969c\u5bb3\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u3053\u3068\u306f\uff0c\u6700\u521d\u304b\u3089\u7cbe\u5ea6\u306e\u9ad8\u3044\u6cbb\u7642<\/span><\/strong>\u3092\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u6b63\u78ba\u306a\u8a3a\u65ad\u3067\u6700\u4f4e\u9650\u306e\u4fb5\u8972\u306e\u6cbb\u7642\u6cd5\u3092\u9078\u3076<\/span><\/strong>\u3053\u3068\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002\u624b\u8853\u306e\u512a\u52a3<\/span><\/strong>\u3082\u60a3\u5150\u306e\u4e88\u5f8c\u3092\u5927\u304d\u304f\u5de6\u53f3\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\uff0c\u677e\u679c\u4f53\u306e\u816b\u760d\u306a\u3069\u3067\u8996\u5e8a\u306e\u640d\u50b7\u306a\u3069\u3092\u751f\u3058\u308c\u3070\u305d\u308c\u3060\u3051\u3067\u9ad8\u6b21\u8133\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u751f\u3058\u307e\u3059\u3002\u9ac4\u819c\u708e\u306a\u3069\u306e\u5408\u4f75\u75c7\u3092\u907f\u3051\u308b<\/span><\/strong>\u3053\u3068\u3082\u5927\u5207\u3067\u3059\u3002\u5316\u5b66\u7642\u6cd5\u5264\u306f\u795e\u7d4c\u6bd2\u6027\u306e\u306a\u3044\u5236\u304c\u3093\u5264<\/span><\/strong>\u3092\u9078\u3093\u3060\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3082\u3063\u3068\u3082\u554f\u984c\u306b\u306a\u308b\u8133\u7167\u5c04\u306f\uff0c\u6b21\u7b2c\u306b\u4f4e\u7dda\u91cf<\/span><\/strong>\u3068\u306a\u308b\u65b9\u5411\u3078\u5411\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u5fd8\u308c\u3066\u3044\u3051\u306a\u3044\u3053\u3068\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u3042\u308b\u304b\u3089\u6cbb\u308b\u816b\u760d\u3082\u591a\u3044\u3053\u3068\u3067\uff0c\u3044\u305f\u305a\u3089\u306b\u7dda\u91cf\u3084\u7167\u5c04\u91ce\u3092\u5c0f\u3055\u304f\u3059\u308c\u3070\u547d\u3092\u5931\u3046\u7d50\u679c\u306b\u306a\u308a\u304b\u306d\u307e\u305b\u3093\u3002\u5b9a\u4f4d\u653e\u5c04\u7dda\u6cbb\u7642\uff08\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u3084\u30b5\u30a4\u30d0\u30fc\u30ca\u30a4\u30d5\uff09\u3042\u308b\u3044\u306f\u967d\u5b50\u7dda\u6cbb\u7642\u304c\uff0c\u6b63\u5e38\u306e\u8133\u306b\u653e\u5c04\u7dda\u3092\u304b\u3051\u306a\u3044\u3067\u816b\u760d\u3060\u3051\u306b\u304b\u3051\u3089\u308c\u308b\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u5c0f\u5150\u306e\u8133\u816b\u760d\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u7406\u7531\u306f\uff0c\u816b\u760d\u304c\u8133\u306b\u6d78\u6f64\u3059\u308b\u3053\u3068\u3068\u9ac4\u6db2\u64ad\u7a2e\u3092\u3059\u308b\u305f\u3081\u3060\u304b\u3089\u3067\u3059\u3002\u4f8b\u3048\u3070\uff0c\u3082\u3068\u3088\u308a\u6d78\u6f64\u6027\u306e\u30b8\u30e3\u30fc\u30df\u30ce\u30fc\u30de\u306b\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u3084\u967d\u5b50\u7dda\u3067\u5c40\u6240\u7167\u5c04\u3092\u3059\u308c\u3070\u518d\u767a\u3057\u3066\uff0c\u6b21\u306e\u6cbb\u7642\u304c\u306a\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u5b9a\u4f4d\u7167\u5c04\u3084\u967d\u5b50\u7dda\u3092\uff0c\u64ad\u7a2e\u306e\u4e88\u9632\u3042\u308b\u3044\u306f\u6cbb\u7642\u306b\u306f\u4f7f\u3048\u306a\u3044\u3053\u3068\u3082\u5fd8\u308c\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u624b\u8853\u3067\u816b\u760d\u306e\u64ad\u7a2e\u3092\u62db\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u816b\u760d\u3092\u6458\u51fa\u3057\u306a\u304c\u3089\u816b\u760d\u7d30\u80de\u3092\u9ac4\u6db2\u306e\u4e2d\u306b\u307e\u304d\u6563\u3089\u3059\u306e\u3067\u3059\u3002\u3082\u3057\u3053\u308c\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3089\uff0c\u5c06\u6765\u306fM0\uff08\u8ee2\u79fb\u306e\u306a\u3044\u60aa\u6027\u816b\u760d\uff09\u306b\u5168\u8133\u7167\u5c04\u3092\u3057\u306a\u304f\u3066\u826f\u3044\u6642\u304c\u6765\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6cbb\u7642\u304c\u6210\u529f\u3057\u3066\u751f\u304d\u6b8b\u3063\u305f\u767d\u8840\u75c5\u306e\u3053\u3069\u3082\u305f\u3061\u3068\u306e\u5927\u304d\u306a\u9055\u3044\u306f\uff0c\u8133\u816b\u760d\u306e\u3053\u3069\u3082\u306b\u91cd\u3044\u5f8c\u907a\u75c7\u304c\u591a\u3044\u3053\u3068\u3067\u3059 \u306a\u304b\u3067\u3082\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3 cognitive dysfunction\u304c\u554f\u984c\u3068\u306a\u308a\u307e\u3059 \u9ad8\u6b21\u8133\u6a5f\u80fd\u969c\u5bb3\uff0c\u5b66\u7fd2\u969c\u5bb3\uff0c\u6ce8\u610f\u6b20\u9665\u969c […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-191","post","type-post","status-publish","format-standard","hentry","category-pediattumor"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=191"}],"version-history":[{"count":20,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/191\/revisions"}],"predecessor-version":[{"id":16238,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/191\/revisions\/16238"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}