{"id":1794,"date":"2013-01-30T08:03:54","date_gmt":"2013-01-29T23:03:54","guid":{"rendered":"\/sawamura\/?p=1794"},"modified":"2026-01-15T16:05:40","modified_gmt":"2026-01-15T07:05:40","slug":"sum","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/sum\/","title":{"rendered":"\u30b0\u30ea\u30aa\u30fc\u30de glioma \u795e\u7d4c\u81a0\u816b (\u3057\u3093\u3051\u3044\u3053\u3046\u3057\u3085)"},"content":{"rendered":"\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\">\u6ce8\u610f\uff01<br>\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b \u3057\u3093\u3051\u3044\u3053\u3046\u3057\u3085\uff09\u306f\u75c5\u540d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"color: #ff0000;\"><span style=\"color: #000000;\">\u30b0\u30ea\u30aa\u30fc\u30de\u306f<\/span><\/span><span style=\"color: #000080;\"><strong>\u8133\u816b\u760d\u306e\uff12\u5272<\/strong><\/span>\u304f\u3089\u3044\u3092\u5360\u3081\u308b\u816b\u760d\u3067\u3059<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3063\u3066\u3082<strong><span style=\"color: #ff0000;\">\u4f55\u5341\u7a2e\u985e\u3082\u3042\u308a\u307e\u3059<\/span><\/strong><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u306e\u306f<\/span><strong><span style=\"color: #ff0000;\">\u6cbb\u7642\u3092\u6c7a\u3081\u308b\u8a3a\u65ad\u540d\u3067\u306f\u306a\u3044<\/span><\/strong>\u306e\u3067\u3059<\/li>\n\n\n\n<li>\u3069\u306e\u56fd\u3067\u3082\uff0c10\u4e07\u4eba\u306b6\u4eba\u7a0b\u5ea6\u306e\u767a\u751f\u7387\u3067\uff0c\u7537\u6027\u306f\u5973\u6027\u306e1.6\u500d\u3067\u3059<\/li>\n\n\n\n<li><span style=\"color: #333333;\"><span style=\"color: #000080;\"><strong>\u60aa\u6027\u816b\u760d\u304c\u591a\u3044<\/strong><\/span>\u3067\u3059<\/span><\/li>\n\n\n\n<li>\u8133\u306e\u795e\u7d4c\u7d30\u80de\u306e\u50cd\u304d\u3092\u52a9\u3051\u308b\u5f79\u76ee\u306e\u7d30\u80de\uff08\u30b0\u30ea\u30a2\uff09\u304c\u816b\u760d\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u3082\u306e\u3067\u3059<\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u3067\u3059\u304b\u3089\uff0c<\/span><strong><span style=\"color: #ff0000;\">\u8133\u306e\u4e2d\u306b\u3057\u307f\u8fbc\u3080<\/span><\/strong>\u3088\u3046\u306b\u767a\u80b2\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u3067\u3059\u304b\u3089\uff0c<strong><span style=\"color: #ff0000;\">\u624b\u8853\u3067\u306f\u7c21\u5358\u306b\u3068\u308c\u307e\u305b\u3093<\/span><\/strong><\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u8a00\u308f\u308c\u305f\u3089<strong><span style=\"color: #ff0000;\">\u547d\u304c\u5371\u306a\u3044\u304b\u3082<\/span><\/strong>\u3068\u8003\u3048\u3066\u304f\u3060\u3055\u3044<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>\u534a\u5e74\u304f\u3089\u3044\u3067\u547d\u3092\u5931\u3046\u3053\u3068\u3082\uff0c30\u5e74\u7d4c\u3063\u3066\u3082\u4f55\u3067\u3082\u306a\u3044<\/strong><\/span>\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">\u6700\u5927\u306e\u7279\u5fb4\u306f\u8133\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u5e83\u304c\u308b\u3053\u3068\u3067\u3059<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3-300x300.jpg\" alt=\"\" class=\"wp-image-23036\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3-550x549.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3-768x767.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt2-3.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"271\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1-300x271.jpg\" alt=\"\" class=\"wp-image-23038\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1-300x271.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1-550x497.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1-768x694.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/diffuseastroyt1-1.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<p>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u306e\u7d44\u7e54\u50cf\u3067\u3059\u3002\u9ec4\u8272\u3044\u77e2\u5370\u306f\u795e\u7d4c\u7d30\u80de\u3067\u5927\u578b\u3067\u3059\u3002\u70b9\u306e\u3088\u3046\u306b\u898b\u3048\u308b\u306e\u304c\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u3067\u3059\u3002\u5de6\u306e\u753b\u50cf\u306e\u88ab\u6bbb\u3068\u3044\u3046\u795e\u7d4c\u7d30\u80de (spindle \/ large round neuron) \u306e\u3042\u308b\u3068\u3053\u308d\uff0c\u53f3\u753b\u50cf\u306e\u767d\u8cea\u3068\u3044\u3046\u3068\u3053\u308d\u306f\uff0c\u816b\u760d\u306b\u4fb5\u3055\u308c\u3066\u3044\u3066\u3082\u306a\u304a\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\u8133\u3067\u3059\u3002\u3053\u3053\u306b\u3042\u308b<span style=\"color: #ff0000;\"><strong>\u816b\u760d\u7d30\u80de\u3092\u624b\u8853\u3067\u5168\u90e8\u3068\u308d\u3046\u3068\u3059\u308c\u3070\uff0c\u3053\u306e\u50cd\u3044\u3066\u3044\u308b\u8133\uff08\u795e\u7d4c\u7d30\u80de\u3068\u795e\u7d4c\u7dda\u7dad\uff09\u3082\u3044\u3063\u3057\u3087\u306b\u53d6\u3063\u3066\u3057\u307e\u3046<\/strong><\/span>\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u5168\u90e8\u53d6\u308c\u306a\u3044\u306e\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u624b\u8853\u3060\u3051\u3067\u306f\u6cbb\u3089\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044<\/strong><\/span>\u3068\u8003\u3048\u3066\u4e0b\u3055\u3044\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8133\u795e\u7d4c\u5916\u79d1\u533b\u306f\u65e5\u5e38\u4f1a\u8a71\u3067\uff0c&#8221;<span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de diffuse glioma<\/strong><\/span>\u201d (\u3073\u307e\u3093\u6027\u795e\u7d4c\u81a0\u816b) \u3092\u300e\u30b0\u30ea\u30aa\u30fc\u30de\u300f\u3068\u3044\u3044\u307e\u3059\u304c\u8aa4\u308a\u3067\u3059<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u89e3\u6c7a\u304c\u3064\u304b\u306a\u3044\u306e\u3067\uff0c<span style=\"color: #000080;\"><strong>\u306a\u3093\u3068\u8a00\u3046\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u4e88\u60f3\u3055\u308c\u308b\u304b<\/strong><\/span><span style=\"color: #000000;\">\u8cea\u554f<\/span>\u3057\u3066\u304f\u3060\u3055\u3044<\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/pediattumor\/pilo\/\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/a><\/span>\uff08\u751f\u547d\u3092\u5931\u3046\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u3044\uff09<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">\u661f\u7d30\u80de\u816b IDH\u5909\u7570\u578b<\/a><\/span><\/span><span style=\"color: #000000;\">\uff081\u5e74\u304b\u308960\u5e74\u306e\u751f\u5b58\u671f\u9593\uff09<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/olig\/\" title=\"\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\">\u4e4f\u7a81\u8d77\u81a0\u816b<\/a><\/span>\uff085\u5e74\u304b\u308960\u5e74\u306e\u751f\u5b58\u671f\u9593\uff09<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/glioma\/glioblastom\/\" title=\"\u81a0\u82bd\u816b\uff08\u3053\u3046\u304c\u3057\u3085\uff09\">\u81a0\u82bd\u816b<\/a><\/span>\uff083\u30f6\u6708\u304b\u30895\u5e74\u306e\u751f\u5b58\u671f\u9593\uff09<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000000;\">\u306a\u3069\u306a\u3069\uff0c\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3060\u3051\u3067\u3082\u3067\u304d\u308b\u90e8\u4f4d\u3068\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u4e88\u5f8c\u306e\u9055\u3044\u304c\u5927\u304d\u3044\u3067\u3059<\/span><\/span><\/li>\n\n\n\n<li>\u7d44\u7e54\u8a3a\u65ad\u3067\u306f\u306a\u304f\u3066<span style=\"color: #000080;\"><strong>\u907a\u4f1d\u5b50\u8a3a\u65ad\u3082\u5fc5\u8981<\/strong><\/span>\u306b\u306a\u308a\u307e\u3057\u305f<\/li>\n\n\n\n<li>\u305f\u3068\u3048\u3070\uff0c\u7b2c1\u67d3\u8272\u4f53\u3068\u7b2c19\u67d3\u8272\u4f53\u306b\u6b20\u5931\u304c\u3042\u308b\u3082\u306e\u3060\u3051\u3092\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3057\u3066\u6cbb\u7642\u3059\u308b<\/li>\n\n\n\n<li>IDH\u907a\u4f1d\u5b50\u306b\u5909\u7570\u306e\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u3001\u653e\u5c04\u7dda\u3084\u5316\u5b66\u7642\u6cd5\u306b\u671f\u5f85\u304c\u6301\u3066\u308b\u306a\u3069\u3067\u3059<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u3067\u3082\uff0c<span style=\"color: #000080;\"><strong>\u540c\u3058<\/strong><\/span><\/span><strong>\u5206\u5b50\u8a3a\u65ad\u3067\u3082\uff0cMRI\u306b\u3088\u308b\u816b\u760d\u5897\u5927\u901f\u5ea6\u306e\u628a\u63e1 radiological growth rate \u306e\u65b9\u304c\u751f\u5b58\u671f\u9593\u3092\u6b63\u78ba\u306b\u4e88\u60f3\u3067\u304d\u307e\u3059<\/strong><\/span>\u306e\u3067\uff0c\u751f\u5b58\u671f\u9593\u306e\u4e88\u60f3\u306b\u306f\u75c5\u7406\u8a3a\u65ad\u306b\u753b\u50cf\u5909\u5316\u3092\u52a0\u3048\u3066\u8aac\u660e\u3092\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u6cbb\u7642\u306e\u6700\u512a\u5148\u76ee\u7684 high priority \u306f\uff0c\u751f\u6d3b\u306e\u8cea QOL \u3092\u4fdd\u3063\u3066\u751f\u5b58\u3059\u308b\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u793e\u4f1a\u5fa9\u5e30\u3092\u76ee\u6307\u3059\u306e\u3067\u3042\u3063\u3066\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u6839\u7d76\u3059\u308b\u3053\u3068\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>2023\u5e74\uff0c\u3044\u307e\u307e\u3067\u6709\u52b9\u306a\u6cbb\u7642\u85ac\u304c\u306a\u304b\u3063\u305f<span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b<\/strong><\/span>\u306b\uff0c<strong><span style=\"color: #ff0000;\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u00a0vorasidenib<\/span><\/strong>\u3068\u3044\u3046\u7d4c\u53e3\u85ac\u304c\u767b\u5834\u3057\u307e\u3057\u305f\u3000\u30fe(^\u25bd^)\u30ce<\/li>\n\n\n\n<li><span style=\"color: #ff0000;\"><strong>\u3082\u3061\u308d\u3093\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3082\u6cbb\u3063\u3066\u3057\u307e\u3046\u60a3\u8005\u3055\u3093\u306f\u305f\u304f\u3055\u3093\u3044\u308b\u306e\u3067\uff0c\u8a3a\u65ad\u3068\u6cbb\u7642\u3092\u614e\u91cd\u306b\u9078\u629e\u3057\u307e\u3057\u3087\u3046<\/strong><\/span><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong>low-grade glioma \u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u7528\u8a9e\u306f\u6cbb\u7642\u9078\u629e\u3067\u4f7f\u308f\u306a\u3044<\/strong><\/span><\/h4>\n\n\n\n<p>\u6587\u732e\u3092\u8aad\u3080\u3068 LGG low-grade glioma\u3068\u3044\u3046\u8a00\u8449\u304c\u5c71\u307b\u3069\u3067\u3066\u304d\u307e\u3059\u3002\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u3082\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c92\u3082LGG\u3067\u3059\u3002\u521d\u671f\u753b\u50cf\u8a3a\u65ad\u6642\u306b\u306f\u7528\u3044\u3066\u3082\u826f\u3044\u306e\u3067\u3059\u304c\uff0c\u4e21\u8005\u306f\u4e88\u5f8c\u3068\u6cbb\u7642\u65b9\u6cd5\u304c\u5168\u304f\u7570\u306a\u308b\u306e\u3067\uff0c\u81e8\u5e8a\u533b\u306f\u6cbb\u7642\u9078\u629e\u6642\u306b\u306f\u3053\u306e\u8a00\u8449\u306b\u5f93\u3063\u305f\u8003\u3048\u3092\u6368\u3066\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/contact-natsume\/\">\u590f\u76ee\u6566\u81f3\u5148\u751f\u304c\u76f8\u8ac7\u306b\u306e\u308a\u307e\u3059\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/h3>\n\n\n\n<p>\u590f\u76ee \u6566\u81f3\uff08\u306a\u3064\u3081 \u3042\u3064\u3057\uff09<br>\u3000\u6cb3\u6751\u75c5\u9662\u3000\u8133\u795e\u7d4c\u5916\u79d1\u90e8\u9577<\/p>\n\n\n\n<p>\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u3064\u3044\u3066\u30e1\u30fc\u30eb\u3067\u76f8\u8ac7\u3067\u304d\u307e\u3059\u3002<strong><a style=\"color: #000080;\" href=\"\/sawamura\/contact-natsume\/\">\u76f8\u8ac7\u30d5\u30a9\u30fc\u30e0\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u958b\u3044\u3066\u304f\u3060\u3055\u3044\u3002<\/a><\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h5 class=\"wp-block-heading\">\u6210\u4eba\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\uff0c\u3073\u307e\u3093\u6027\u795e\u7d4c\u81a0\u816b\uff0cdiffuse glioma<\/h5>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u8133\u5916\u79d1\u533b\u304c\u4f1a\u8a71\u3068\u8aac\u660e\u3067\u4f7f\u3046\u30b0\u30ea\u30aa\u30fc\u30de<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8133\u795e\u7d4c\u5916\u79d1\u533b\u306f\u65e5\u5e38\u4f1a\u8a71\u3067\uff0c&#8221;<span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de diffuse glioma<\/strong><\/span>\u201d (\u3073\u307e\u3093\u6027\u795e\u7d4c\u81a0\u816b) \u3092\u300e\u30b0\u30ea\u30aa\u30fc\u30de\u300f\u3068\u3044\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u6163\u7fd2\u3068\u3057\u3066\u6b21\u306e\uff0c3\u3064\u306e\u816b\u760d\u304c\u3075\u304f\u307e\u308c\u307e\u3059<\/li>\n\n\n\n<li>\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u3068\u4e4f\u7a81\u8d77\u81a0\u816b\u3092\uff0c<span style=\"color: #000080;\"><strong>low-grade glioma LGG \u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u6b63\u78ba\u306a\u7528\u8a9e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u306e\u3067\uff0c\u306a\u308b\u3079\u304f\u4f7f\u308f\u306a\u3044<\/li>\n\n\n\n<li>\u307e\u3060\u7d30\u5206\u985e\u3082\u3042\u308a\u307e\u3059\u306e\u304c\uff0c\u77e5\u308a\u305f\u3044\u65b9\u306f\u30af\u30ea\u30c3\u30af\u3057\u3066\u5404\u9805\u76ee\u3092\u958b\u3044\u3066\u8aad\u3093\u3067\u304f\u3060\u3055\u3044<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\">1. <a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffuseastrocytoma\/\">\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c9 2, 3, 4<\/a><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\">2. <span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"\/sawamura\/glioma\/olig\/\"><span style=\"color: #000080;\">\u4e4f\u7a81\u8d77\u81a0\u816b \u30b0\u30ec\u30fc\u30c9 2, 3<\/span><\/a><\/span><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\">3. <\/span><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/glioblastom\/\">\u81a0\u82bd\u816b \u30b0\u30ec\u30fc\u30c9 4<\/a><\/span><\/h5>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #ff0000;\"><strong>\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e1\u5e74\u751f\u5b58\u5272\u5408<\/strong><\/span>\uff08\u7c73\u56fd\u306e8,651\u4f8b\u306e\u89e3\u6790\uff09<\/h4>\n\n\n\n<p class=\"heading-title\">Ostrom QT: National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States. Neuro Oncol 2023<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"color: #000080;\"><strong>98.0%<\/strong><\/span> :\u00a0WHO grade 2 IDH-mutant \u661f\u7d30\u80de\u816b<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>92.4%<\/strong><\/span> : WHO grade 3 IDH-mutant \u661f\u7d30\u80de\u816b<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>76.3%<\/strong><\/span> : WHO grade 4 IDH-mutant \u661f\u7d30\u80de\u816b<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>97.9%<\/strong><\/span> : WHO grade 2 IDH-mutant 1p\/19q-codeleted \u4e4f\u7a81\u8d77\u81a0\u816b<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>94.4%<\/strong><\/span> : WHO grade 3 IDH-mutant 1p\/19q-codeleted \u4e4f\u7a81\u8d77\u81a0\u816b<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>55.9%<\/strong><\/span> : H3 K27M-mutant diffuse midline gliomas\uff08\u3053\u308c\u306f\u4e3b\u3068\u3057\u3066\u5c0f\u5150\u816b\u760d\u3067\u3059\uff09<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>53.7%<\/strong><\/span> : WHO grade 4 IDH-wildtype \u81a0\u82bd\u816b<\/li>\n<\/ul>\n\n\n\n<p>\u540c\u3058\u30b0\u30ec\u30fc\u30c94\u3067\u3082\uff0c\u81a0\u82bd\u816b\u3088\u308a\u661f\u7d30\u80de\u816b\u306e\u751f\u5b58\u5272\u5408\u306f\u9ad8\u3044\u3067\u3059<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h5 class=\"wp-block-heading\">\u8a3a\u65ad\u306b\u306f\u753b\u50cf\u8a3a\u65ad\u3068\u75c5\u7406\u8a3a\u65ad\u304c\u3042\u308a\u307e\u3059<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u753b\u50cf\u8a3a\u65ad\u3067\u4e88\u60f3\u3092\u6df1\u3081\u308c\u3070\uff0c\u6cbb\u7642\u306e\u65b9\u5411\u6027\u306f\u3060\u3044\u305f\u3044\u4e88\u60f3\u3067\u304d\u307e\u3059<\/li>\n\n\n\n<li>\u75c5\u7406\u8a3a\u65ad\u3067\u78ba\u5b9a\u3059\u308c\u3070\uff0c\u6cbb\u7642\u306e\u65b9\u5411\u6027\u304c\u6c7a\u307e\u308a\u307e\u3059<\/li>\n\n\n\n<li><span style=\"color: #ff0000;\"><strong>2021\u5e74\u306eWHO\u5206\u985e\u3067\u306f<\/strong><\/span><span style=\"color: #ff0000;\"><strong>\u540c\u3058\u8a3a\u65ad\u540d\u3067\u3082\uff0c\u7d44\u7e54\u5b66\u7684\u306a\u60aa\u6027\u5ea6\u304c\u7570\u306a\u308b\u3068\u9055\u3063\u305f\u6cbb\u7642\u6cd5\u306b\u306a\u308b\u306e\u3067\u3068\u3066\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059! \u00a0 \u661f\u7d30\u80de\u816b\u306f\u30b0\u30ec\u30fc\u30c92\u304b\u30894\u307e\u3067\u3042\u308a\u307e\u3059\u3002<\/strong><\/span><\/li>\n\n\n\n<li>\u533b\u5e2b\u304b\u3089\u306e\uff0c\u300c\u624b\u8853\u3057\u3066\u75c5\u7406\u3092\u898b\u306a\u3051\u308c\u3070\u826f\u6027\u304b\u60aa\u6027\u304b\u308f\u304b\u3089\u306a\u3044\u300d\u3068\u3044\u3046\u8aac\u660e\u306f\u4e71\u66b4\u3067\uff0c\u753b\u50cf\u8a3a\u65ad\u3067\u3082\u307b\u3068\u3093\u3069\u306e\u3053\u3068\u306f\u5206\u304b\u308b\u3082\u306e\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u753b\u50cf\u8a3a\u65ad<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>MRI\u3068CT\u3092\u7528\u3044\u307e\u3059<\/li>\n\n\n\n<li>MRI\u3067\u306f\u7279\u306b\uff0c T2\u5f37\u8abf\u753b\u50cf\uff0cFLAIR\u753b\u50cf\uff0cT1\u5f37\u8abf\u3068\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u306e\u8ef8\u9762\uff0c\u51a0\u72b6\u65ad\uff0c\u77e2\u72b6\u65ad\u3092\u64ae\u5f71\u3057\u307e\u3059 golden standard\u3068\u3055\u308c\u307e\u3059<\/li>\n\n\n\n<li>\u751f\u691c\u8853\u3092\u884c\u3046\u6642\u306b\u306f\uff0cperfusion MRI\u3084\u30e1\u30c1\u30aa\u30cb\u30f3\u30da\u30c3\u30c8\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7d5e\u308b\u306e\u306b\u6709\u52b9\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><span style=\"color: #000080;\">\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b\uff09\u3068\u8a00\u308f\u308c\u3066\u307e\u305a\u6700\u521d\u306b\u805e\u304b\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068<\/span><\/strong><\/h4>\n\n\n\n<div>\n<ul>\n<li>\u30b0\u30ea\u30aa\u30fc\u30de \u795e\u7d4c\u81a0\u816b\u3068\u3044\u3046\u306e\u306f\u8133\u304b\u3089\u767a\u751f\u3059\u308b\u816b\u760d\u306e\u7dcf\u79f0\u3067\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u3060\u304b\u3089\u3068\u3044\u3063\u3066\u3082\u4f55\u304c\u306a\u3093\u3060\u304b\u308f\u304b\u308a\u307e\u305b\u3093\u3057\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u3060\u304b\u3089\u624b\u8853\u3059\u308b\u3068\u304b\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u5fc5\u8981\u3060\u3068\u304b\u3044\u3046\u8aac\u660e\u306f\u901a\u3058\u307e\u305b\u3093<\/li>\n<li>MRI\u6240\u898b\u304b\u3089\u3069\u306e\u3088\u3046\u306a\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b\uff09\u3067\u3059\u304b\u3068\u8cea\u554f\u3057\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u4e88\u60f3\u3055\u308c\u308b\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad<\/span><\/strong>\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3068\u8a00\u3044\u307e\u3059<\/li>\n<li>\u305d\u3053\u3067\u7b54\u3048\u3089\u308c\u306a\u3044\u306a\u3089\uff0c\u5225\u306a\u8133\u795e\u7d4c\u5916\u79d1\u533b\u3092\u9078\u3073\u307e\u3059<\/li>\n<li>\u305d\u3046\u3057\u306a\u3044\u3068<span style=\"color: #ff0000;\"><strong>\u547d\u304c\u5371\u306a\u3044\u75c5\u6c17\u3067\u3059<\/strong><\/span><\/li>\n<\/ul>\n<figure><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13307\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1-300x296.jpg\" alt=\"\" width=\"300\" height=\"296\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1-300x296.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1-768x758.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1-550x543.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder1.jpg 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure><figure><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-13308\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2-300x292.jpg\" alt=\"\" width=\"300\" height=\"292\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2-300x292.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2-768x747.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2-550x535.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/glioblastomaelder2.jpg 945w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure><p><\/p>\n<p>\u9ad8\u9f62\u8005\u306b\u767a\u751f\u3057\u305f\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059\u3002\u5de6\u306f\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37MRI\u3068\u3044\u3044\u307e\u3059\u3002\u816b\u760d\u306e\u5468\u56f2\u304c\u767d\u304f\u7e01\u53d6\u3089\u308c\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002\u3067\u3082\uff0c\u53f3\u5074\u306eT2\u5f37\u8abf\u753b\u50cf\u3067\u306f\uff0c\u767d\u304f\u6ef2\u3080\u90e8\u5206\u304c\u5468\u56f2\u306b\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30b0\u30ec\u30fc\u30c93\uff08\u304b\u3064\u3066\u306e\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff09\u304b\u30b0\u30ec\u30fc\u30c94\uff08\u81a0\u82bd\u816b\uff09\uff0c\u304a\u305d\u3089\u304f\u81a0\u82bd\u816b\u3068\u300c\u4e88\u60f3\u300d\u3067\u304d\u308b\u753b\u50cf\u3067\u3059\u3002\u78ba\u5b9f\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u4e88\u60f3\u306f\u6cbb\u7642\u8a08\u753b\u306e\u4e0a\u3067\u91cd\u8981\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4><a href=\"\/sawamura\/glioma\/gliomamoleculardiag\/\"><span style=\"color: #000080;\">\u75c5\u7406\u8a3a\u65ad\u3067\u306f\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u304f\u306a\u3063\u305f\u3053\u3068<\/span><\/a><\/h4>\n<p>\u307e\u305a\u75c5\u7406\u7d44\u7e54\u50cf\u3067\u8a3a\u65ad\u540d\u304c\u3064\u304d\u307e\u3059\u3002\u305d\u308c\u304b\u3089\uff0cIDH\u3068\u3044\u3046\u907a\u4f1d\u5b50\u3068\uff0c1p\/19q\u3068\u3044\u3046\u67d3\u8272\u4f53\uff08FISH\u3068\u3044\u3046\u691c\u67fb\uff09\u3067\u307f\u306a\u3051\u308c\u3070\uff0c\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u78ba\u5b9a\u8a3a\u65ad\u306f\u3064\u3051\u3089\u308c\u306a\u3044\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h5>\u6210\u4eba\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u30002021\u5e74\u306e\u5206\u985e\u306f3\u7a2e\u985e<\/h5>\n<\/div>\n\n\n\n<p><a title=\"\u661f\u7d30\u80de\u816b IDH\u5909\u7570\u578b astroytoma IDH-mutant WHO grade 2, 3, 4\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b diffuse astrocytoma WHO grade 2\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/diffuseastrocytoma\/\"><span style=\"color: #000080;\"><strong>\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c92\u304b3\u304b4\uff08\u6cbb\u7642\u65b9\u6cd5\u304c\u30b0\u30ec\u30fc\u30c9\u3067\u7570\u306a\u308a\u307e\u3059\uff09<\/strong><\/span><\/a><br>Astrocytoma, <strong><span style=\"color: #ff0000;\">IDH mutant<\/span><\/strong>, <strong><span style=\"color: #ff0000;\">nuclear ATRX lost<\/span><\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/olig\/\"><span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u816b \u30b0\u30ec\u30fc\u30c92\u304b3\uff08\u6cbb\u7642\u65b9\u6cd5\u304c\u30b0\u30ec\u30fc\u30c9\u3067\u7570\u306a\u308a\u307e\u3059\uff09<\/strong><\/span><\/a><br>Oligodendroglioma, <span style=\"color: #ff0000;\"><strong>IDH mutant<\/strong><\/span>, nuclear ATRX retained, <span style=\"color: #ff0000;\">1p\/19q codeleted<\/span><\/p>\n\n\n\n<p><a title=\"\u81a0\u82bd\u816b\uff08\u3053\u3046\u304c\u3057\u3085\uff09\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/glioblastom\/\"><span style=\"color: #000080;\"><strong>\u81a0\u82bd\u816b \u30b0\u30ec\u30fc\u30c94<\/strong><\/span><\/a><br>Glioblastoma, <span style=\"color: #ff0000;\"><strong>IDH wildtype<\/strong><\/span>, nuclear ATRX retained, typical histology or TERT, EGFR, +7\/-10<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u5c0f\u5150\u30bf\u30a4\u30d7\u306e\u3073\u307e\u3093\u6027\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u30002021\u5e74\u306e\u5206\u985e\u306f4\u7a2e\u985e<br>Pediatric-type diffuse low-grade gliomas<\/h5>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b,&nbsp;<em>MYB<\/em>\u3042\u308b\u3044\u306f<em>MYBL1&nbsp;<\/em>\u907a\u4f1d\u5b50\u7570\u5e38&nbsp;&nbsp;(\u30b0\u30ec\u30fc\u30c91)<\/strong><\/span><br><span style=\"color: #000080;\"><strong>Diffuse astrocytoma, <em>MYB<\/em> or <em>MYBL1<\/em>-altered<\/strong><\/span><\/p>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/pediattumor\/hamartomas\/\"><span style=\"color: #000080;\"><strong>\u8840\u7ba1\u4e2d\u5fc3\u6027\u81a0\u816b \u30a2\u30f3\u30b8\u30aa\u30bb\u30f3\u30c8\u30ea\u30c3\u30af\u30fb\u30b0\u30ea\u30aa\u30fc\u30de&nbsp; (\u30b0\u30ec\u30fc\u30c91)<\/strong><\/span><\/a><br><span style=\"color: #000080;\"><strong>Angiocentric glioma<\/strong><\/span><\/p>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/pediattumor\/hamartomas\/\"><strong><span style=\"color: #000080;\">Polymorphous low-grade neuroepithelial tumor of the young&nbsp; (\u30b0\u30ec\u30fc\u30c91)<\/span><\/strong><\/a><\/p>\n\n\n\n<p><strong><span style=\"color: #000080;\">MAPK pathway\u306b\u7570\u5e38\u304c\u3042\u308b\u3073\u307e\u3093\u6027\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de<br>Diffuse low-grade glioma, MAPK pathway-altered<\/span><\/strong><\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/pediatricdiffusehighgrageglioma\/\">\u5c0f<span style=\"color: #000080;\">\u5150\u30bf\u30a4\u30d7\u306e\u3073\u307e\u3093\u6027\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de<\/span><\/a><span style=\"color: #000080;\">\u30002021\u5e74\u306e\u5206\u985e\u306f4\u7a2e<\/span><br><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/pediatricdiffusehighgrageglioma\/\">Pediatric-type diffuse high-grade gliomas<\/a><\/span><\/h5>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/diffusemidlineglioma\/\"><strong><span style=\"color: #000080;\">\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de&nbsp; H3 K27\u907a\u4f1d\u5b50\u7570\u5e38<\/span><\/strong><\/a>&nbsp;(\u30b0\u30ec\u30fc\u30c94)<br><span style=\"color: #000080;\"><strong>Diffuse midline glioma<\/strong><\/span>, <span style=\"color: #000080;\"><strong>H3 K27-altered,&nbsp;<\/strong><\/span>IDH wildtype, nuclear ATRX retained<\/p>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u534a\u7403\u6027\u30b0\u30ea\u30aa\u30fc\u30de&nbsp;H3.3 G34\u5909\u7570\u578b<\/strong><\/span>&nbsp;(\u30b0\u30ec\u30fc\u30c94)<br><strong><span style=\"color: #000080;\">Diffuse hemispheric&nbsp;<\/span><\/strong><span style=\"color: #000080;\"><span style=\"caret-color: #000080;\"><b>glioma<\/b><\/span><\/span>, <span style=\"color: #000080;\"><strong>H3.3 G34 mutant,&nbsp;<\/strong><\/span>IDH wildtype, nuclear ATRX lost, age&lt;50<\/p>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u5c0f\u5150\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de&nbsp;(\u30b0\u30ec\u30fc\u30c94)<\/strong><\/span><br><span style=\"color: #000080;\"><strong>Diffuse pediatric-type high-grade glioma, &nbsp;H3-wildtype and IDH-wildtype<\/strong><\/span><\/p>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u4e73\u5150\u534a\u7403\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span><br><span style=\"color: #000080;\"><strong>Infant-type hemispheric glioma<\/strong><\/span><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u5883\u754c\u660e\u77ad\u306a\u661f\u7d30\u80de\u7cfb\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u3073\u307e\u3093\u6027\u3067\u306f\u306a\u3044\uff09<\/h5>\n\n\n\n<p><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilo\/\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/a><br>Pilocytic astrocytoma (\u30b0\u30ec\u30fc\u30c91)\u3000<\/span><\/strong><\/p>\n\n\n\n<p><strong><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/pilo\/\"><span style=\"color: #000080;\"><span style=\"caret-color: #000080;\">piloid-features\u3092\u542b\u3080\u9ad8\u60aa\u6027\u5ea6\u661f\u7d30\u80de\u816b (\u30b0\u30ec\u30fc\u30c94)<\/span><\/span><\/a><br><span style=\"color: #000080;\">High-grade astrocytoma with piloid features<\/span><\/strong><\/p>\n\n\n\n<p><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/glioma\/pleomorphicxantho\/\">\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b<\/a><\/strong><\/span><br><span style=\"color: #000080;\"><strong>Pleomorphic xanthoastrocytoma (\u30b0\u30ec\u30fc\u30c9 2, 3)<\/strong><\/span><\/p>\n\n\n\n<p><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/pediattumor\/subepgiantastro\/\">\u4e0a\u8863\u4e0b\u5de8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b (\u30b0\u30ec\u30fc\u30c91)<\/a><\/strong><\/span><br><span style=\"color: #000080;\"><strong>Subependymal &nbsp;giant cell astrocytoma SEGA<\/strong><\/span><\/p>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/chordoidglioma\/\"><span style=\"color: #000080;\"><strong>\u810a\u7d22\u816b\u69d8\u81a0\u816b \u30b3\u30eb\u30c9\u30a4\u30c9\u30fb\u30b0\u30ea\u30aa\u30fc\u30de (\u30b0\u30ec\u30fc\u30c91)<\/strong><\/span><\/a><br><span style=\"color: #000080;\"><strong>Chordoid glioma<\/strong><\/span><\/p>\n\n\n\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/astroblastoma\/\"><span style=\"color: #000080;\"><strong>\u661f\u82bd\u816b, <em>MN1<\/em>-\u907a\u4f1d\u5b50\u7570\u5e38<\/strong><\/span><\/a><br><span style=\"color: #000080;\"><strong>Astroblastoma, <em>MN1<\/em>-altered<\/strong><\/span><\/p>\n\n\n\n<div><hr>\n<h5><a href=\"\/sawamura\/braintumors\/malignancy\/\"><strong><span style=\"color: #000080;\">\u60aa\u6027\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f<\/span><\/strong><span style=\"color: #000080;\">\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/span><\/a><\/h5>\n<p>\u305d\u308c\u305e\u308c\u306e\u8133\u816b\u760d\u304c\u6cbb\u308a\u3084\u3059\u3044\u304b\u6cbb\u308a\u306b\u304f\u3044\u304b\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c9\uff11\uff0c\u30b0\u30ec\u30fc\u30c92\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\uff0c\u30b0\u30ec\u30fc\u30c9\uff14\u304c\u3042\u308a\u307e\u3059\u3002\u60a3\u8005\u3055\u3093\u5074\u306e\u89b3\u70b9\u304b\u3089\u306f\u30b0\u30ec\u30fc\u30c9\uff11\u3060\u3051\u304c\u826f\u6027\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u60aa\u6027\u5ea6\u306f\u5f93\u6765\u3069\u304a\u308a\u306e\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306b\u307b\u307c\u4f9d\u5b58\u3057\u307e\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c92\u304b3\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3082\uff0c\u6cbb\u7642\u306f\u5f93\u6765\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u6e96\u305a\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059<\/p>\n<h1><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/2016who\/\">\u4ed6\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u306e WHO 2021\u5e74\u5206\u985e\u306f \u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/span><\/h1>\n<h1><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/2016who\/\">\u3044\u308d\u3044\u308d\u306a\u73cd\u3057\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u75c5\u540d\u3068\u8a73\u7d30\u306a\u8a18\u8ff0\u306b\u5165\u308c\u307e\u3059<\/a><\/span><\/h1>\n<hr>\n<h5>\u624b\u8853\u6cbb\u7642<\/h5>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u4e16\u754c\u306e\u5e38\u8b58&nbsp;Most diffuse gliomas are not cured by surgery!<\/strong><\/h4>\n\n\n\n<p>cure\u3068\u3044\u3046\u306e\u306f\u65e5\u672c\u8a9e\u306b\u8a33\u3059\u3068\u300c\u5b8c\u6cbb\u305b\u3057\u3081\u308b\u300d\u3068\u8a00\u3046\u610f\u5473\u3067\u3059<\/p>\n\n\n\n<div><hr>\n<h4><strong><span style=\"color: #000080;\">\u6ce8\u610f\uff01\u3000\u300c\u30cd\u30c3\u30c8\u3084\u96d1\u8a8c\u306e\u5ba3\u4f1d\u300d\u306b\u60d1\u308f\u3055\u308c\u3066\u306f\u3044\u3051\u306a\u3044<\/span><\/strong><\/h4>\n<\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><span style=\"color: #ff0000;\"><strong>\u3042\u308b\u7a0b\u5ea6\uff0c\u3042\u308b\u5834\u5408\u306b\u306f\uff0c\u6709\u52b9\u304b\u3082\u3057\u308c\u306a\u3044\u3051\u308c\u3069\uff0c\u79d1\u5b66\u7684\u306b\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3082\u306e\u304c\u591a\u3044\u3067\u3059<\/strong><\/span><\/strong><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u5b66\u4f1a\u306a\u3069\u3067\u767a\u8868\u3055\u308c\u3066\uff0c\u6700\u65b0\u3042\u308b\u3044\u306f\u5fc5\u9808\u306e\u6cbb\u7642\u6cd5\uff0c\u5148\u9032\u533b\u7642\u306e\u3088\u3046\u306b\u5ba3\u4f1d\u3055\u308c\u307e\u3059\u304c\uff0c\u5b9f\u969b\u306e\u3068\u3053\u308d\u306f\u9577\u671f\u751f\u5b58\u5272\u5408\u306b\u306f\u5927\u304d\u304f\u5f71\u97ff\u3057\u306a\u3044\u3082\u306e\u3067\u3059<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\">\u300c<span style=\"color: #000080;\"><strong>\u3057\u3063\u304b\u308a\u3057\u305f\u82f1\u8a9e\u306e\u8ad6\u6587\u3067\u30ec\u30d9\u30eb\u306e\u9ad8\u3044\u5b66\u8853\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u305f\u4fe1\u983c\u3059\u308b\u306b\u8db3\u308b<\/strong><\/span><\/span><span style=\"color: #000000;\"><span style=\"color: #000080;\"><strong>\u79d1\u5b66\u7684\u306a\u5b9f\u7e3e<\/strong><\/span>\u300d\u306f\u306a\u304f\u3066\uff0c\u60a3\u8005\u3055\u3093\u3092\u5f15\u304d\u3064\u3051\u308b\u305f\u3081\u306e\u5ba3\u4f1d\u304c\u591a\u3044\u3068\u8003\u3048\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\">\u3053\u306e\u3088\u3046\u306a\u79d1\u5b66\u7684\u6839\u62e0\u3068\u3044\u3046\u3082\u306e\u306f<span style=\"color: #ff0000;\"><strong>\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb<\/strong><span style=\"color: #333333;\">\u3068\u3044\u3046\u3082\u306e\u3067\u8a55\u4fa1<\/span><\/span>\u3055\u308c\u307e\u3059\u304b\u3089\uff0c\u300c<span style=\"color: #000080;\"><strong>\u65e5\u672c\u8a9e\u3067\u81ea\u524d\u306e\u826f\u3044\u6210\u7e3e<\/strong><\/span>\u300d\u304c\u66f8\u304b\u308c\u3066\u3044\u3066\u3082\u4f55\u306e\u8a3c\u660e\u306b\u3082\u306a\u308a\u307e\u305b\u3093<\/span><\/li>\n\n\n\n<li><span style=\"color: #000000;\">\u3082\u3061\u308d\u3093\uff0c\u75c5\u9662\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306b\u81ea\u66f8\u3067\u8f09\u305b\u3066\u3042\u308b\u6210\u7e3e\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093<\/span><\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\uff0c<span style=\"color: #000080;\"><strong>\u30a2\u30df\u30ce\u30ec\u30d6\u30f3\u30ea\u30f3\u9178(ALA)\u3092\u4f7f\u3046\u3053\u3068\u3067\uff0c\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6458\u51fa\u7387\u304c\u5411\u4e0a<\/strong><\/span>\u3059\u308b\u3068\u3044\u3046\u306e\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\uff0c\u8a71\u304c\u96e3\u3057\u3044\u306e\u3067\u3059\u304c\u6458\u51fa\u7387\u3068\u751f\u5b58\u671f\u9593\u3068\u3044\u3046\u306e\u306f\u4e00\u81f4\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u6fa4\u6751\u306fALA\u3092\u4f7f\u7528\u3057\u3066\u624b\u8853\u3057\u3066\u3044\u307e\u3059\uff0c\u3067\u3082\u60a3\u8005\u3055\u3093\u306b\u306f\uff0c\u305d\u308c\u306b\u3088\u3063\u3066\u5ef6\u547d\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3068\u306f\u8aac\u660e\u3057\u307e\u305b\u3093<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>\u899a\u9192\u4e0b\u624b\u8853\u306f\u304b\u306a\u308a\u9650\u3089\u308c\u305f\u6761\u4ef6<\/strong><\/span>\u3067\u3057\u304b\u884c\u3046\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff0c\u307b\u3068\u3093\u3069\u306e\u624b\u8853\u3067\u306f\u7121\u7528\u306a\u3082\u306e\u3067\u3059<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>\u30aa\u30d7\u30c1\u30e5\u30fc\u30f3 NovoTTF\u306f\uff0c\u81a0\u82bd\u816b\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u3092\u5ef6\u9577\u3057\u307e\u3059<\/strong><\/span>\u304c\uff0c\u304b\u306a\u308a\u9650\u3089\u308c\u305f\u6761\u4ef6\u3067\u306e\u4f7f\u7528\u3068\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/intraoperativeimaging\/\">\u30a4\u30e1\u30fc\u30b8\u30fb\u30ac\u30a4\u30c9\u624b\u8853\uff1a<\/a><\/span><\/h5>\n\n\n\n<p><strong><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/intraoperativemri\/\">\u8853\u4e2dMRI<\/a>\uff0c<a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/aminolevulinicacid\/\">ALA\uff08\u30a2\u30e9\u30d9\u30eb\uff09\u306b\u3088\u308b\u53ef\u8996\u5316<\/a><\/strong>\uff0c\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u306a\u3069\u3092\uff0c\u8853\u4e2d\u30a4\u30e1\u30fc\u30b8\u30fb\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3068\u3044\u3044\u307e\u3059<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong>\u899a\u9192\u4e0b\u624b\u8853<\/strong><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/immunotherap\/\">\u514d\u75ab\u6cbb\u7642\uff08\u81ea\u5df1\u6a39\u72b6\u7a81\u8d77\u7d30\u80de\uff0c\u30ef\u30af\u30c1\u30f3\u6cbb\u7642\uff0c\u30ea\u30f3\u30d1\u7403\u6d3b\u6027\u5316\u6cbb\u7642\uff09<\/a><\/strong><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/home\/aminolevulinicacid\/\">\u30a2\u30df\u30ce\u30ec\u30d6\u30ea\u30f3\u9178(ALA)\u306b\u3088\u308b\u53ef\u8996\u5316\u3068\u5149\u7dda\u529b\u5b66\u6cbb\u7642(PDT)<\/a><\/strong><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/braintumors\/particleprotonbeam\/\"><strong>\u91cd\u7c92\u5b50\u7642\u6cd5\uff0c\u4e2d\u6027\u5b50\u88dc\u8db3\u7642\u6cd5<\/strong><\/a><\/span><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"NovoTTF tumor treatment field\" href=\"\/sawamura\/braintumors\/glioma\/novottf\/\">NovoTTF\uff08\u30aa\u30d7\u30c1\u30e5\u30fc\u30f3\uff09<\/a><\/strong><\/span><\/h5>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h5 class=\"wp-block-heading\">\u7d44\u7e54\u8a3a\u65ad\uff0c\u5f62\u614b\u7684\u8a3a\u65ad histological&nbsp;phenotypic diagnosis<br>\u5206\u5b50\u8a3a\u65ad\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad molecular genetic diagnosis<\/h5>\n\n\n\n<p>2016\u5e74\u307e\u3067\u306f\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u75c5\u7406\u8a3a\u65ad\u533b\u304c\uff0c\u9855\u5fae\u93e1\u3092\u8997\u3044\u3066\u8a3a\u65ad\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3092\u7d44\u7e54\u8a3a\u65ad\uff08\u5f62\u614b\u5b66\u7684\u8a3a\u65ad\uff09\u3068\u3044\u3044\u307e\u3059\u3002\u3067\u3082\u3053\u308c\u304b\u3089\u306f\uff0c\u5206\u5b50\u89e3\u6790\u306b\u3088\u308b\u907a\u4f1d\u5b50\u8a3a\u65ad\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/2016who\/\">WHO 2016\u5e74\u5206\u985e<\/a>\u306b\u3088\u308b\u5927\u6df7\u4e71<\/strong><\/span><\/h4>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e00\u756a\u306e\u7406\u7531\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u3053\u306e\u6570\u5341\u5e74\u9593\u7a4d\u307f\u91cd\u306a\u3063\u3066\u304d\u305f\u4e16\u754c\u306e\u8133\u816b\u760d\u306e\u6cbb\u7642\u30c7\u30fc\u30bf\u304c\u898b\u3048\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3046<\/strong><\/span>\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li><span style=\"color: #333333;\"><a style=\"color: #333333;\" href=\"\/sawamura\/braintumors\/2016who\/\">\u65b0\u3057\u3044\u5206\u985e\u306f\u4ed6\u306e\u30da\u30fc\u30b8\u306b\u66f8\u3044\u3066\u3042\u308b\u306e\u3067\u898b\u3066\u304f\u3060\u3055\u3044\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/li>\n\n\n\n<li>\u3053\u308c\u307e\u3067\u3082\u591a\u5c11\u306e\u75c5\u7406\u8a3a\u65ad\u306e\u5b9a\u7fa9\u306e\u5909\u5316\u306f\u3042\u3063\u305f\u306e\u3067\u3059\u304c\uff0c\u4eca\u56de\u306f\u3042\u307e\u308a\u306b\u6fc0\u5909 drastic change \u3067\u3057\u305f<\/li>\n\n\n\n<li>\u305f\u3068\u3048\u3070\uff0c\u9855\u5fae\u93e1\u3067\u8997\u3044\u3066\u300c\u4e4f\u7a81\u8d77\u81a0\u816b\u300d\u3068\u8a3a\u65ad\u3057\u3066\u3044\u305f\u3082\u306e\u304c\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad\u3057\u306a\u304a\u3059\u3068\u300c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u300d\u306b\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u514d\u75ab\u7d44\u7e54\u8a3a\u65ad\u3067\u300c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u300d\u3067\u3042\u3063\u305f\u3082\u306e\u304c\uff0c FISH\u3067\u300c\u81a0\u82bd\u816b\u300d\u306b\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u3053\u3068\u3082\u983b\u5ea6\u3068\u3057\u3066\u306f\u9ad8\u3044\u3067\u3057\u3087\u3046<\/li>\n\n\n\n<li>\u305d\u306e\u9006\u3082\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u6587\u732e\u3067\u8abf\u3079\u3066\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u81e8\u5e8a\u6210\u7e3e\u3068\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u306b\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3084\u81a0\u82bd\u816b\u304c\u5927\u91cf\u306b\u6df7\u3058\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u65b0\u3057\u3044\u5206\u985e\u3092\u63a1\u7528\u3059\u308b\u3068\uff0c\u904e\u53bb\u306e\u6587\u732e\u306e\u30c7\u30fc\u30bf\u306b\u3088\u308b\u6839\u62e0\u306b\u57fa\u3065\u304f\u533b\u7642 EBM\u304c\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u3067\u306f\u3069\u3053\u306b\uff0c\u305d\u306e\u816b\u760d\u306e\u3053\u3068\u304c\u66f8\u3044\u3066\u3042\u308b\u304b\u3068\u3044\u3048\u3070\uff0c\u82f1\u8a9e\u3067\u4e16\u754c\u306e\u6587\u732e\u60c5\u5831\u3092\u63a2\u3063\u3066\u3082\u4f55\u306b\u3082\u51fa\u3066\u304d\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u306a\u305c\u306a\u3089\uff0c\u3053\u306e\u5206\u985e\u306b\u3088\u308b\u6cbb\u7642\u6210\u7e3e\u3084\u60a3\u8005\u3055\u3093\u306e\u4e88\u5f8c\u306f\uff0c\u4eca\u5f8c20\u5e74\u304f\u3089\u3044\u304b\u304b\u3063\u3066\u5f90\u3005\u306b\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304f\u308b\u304b\u3089\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><span style=\"color: #ff0000;\">\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6839\u62e0\u306a\u304d\u6cbb\u7642 non-EBM \u304c\u59cb\u307e\u308a\u307e\u3059<\/span><\/h5>\n\n\n\n<h4 class=\"wp-block-heading\">\u308f\u304b\u308a\u306b\u304f\u3044\u306e\u3067\u4f8b\u3092\u3042\u3052\u307e\u3057\u3087\u3046<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b \u30b0\u30ec\u30fc\u30c9\uff13\u3092\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u898b\u76f4\u3057\u3066\u307f\u305f\u3089<\/h4>\n\n\n\n<p>Dubbink HJ, et al.: Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial. Neuro Oncol 18:388-400, 2015<\/p>\n\n\n\n<p>\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u884c\u308f\u308c\u305f\u5927\u304d\u306a\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\uff08EORTC 26951\uff09\u3092\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u518d\u5206\u6790\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4 AO, AOA\u3068\u8a3a\u65ad\u3055\u308c\u3066\u81e8\u5e8a\u8a66\u9a13\u3055\u308c\u305f126\u4f8b\u3092\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u898b\u76f4\u3057\u305f\u3089\uff0c20\u4f8b\u304c I<span class=\"highlight\">DH<\/span>&nbsp;mutation, \u201c<span class=\"highlight\">astrocytoma<\/span>\u201c\uff0c49\u4f8b\u304c1p\/19q codeletion, \u201coligodendroglioma\u201d\uff0c55\u4f8b\u304c7+\/10q- or TERTmut and 1p\/19q intact, \u201cglioblastoma\u201d\u3060\u3063\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002<br>\u306a\u3093\u306e\u3053\u3063\u3061\u3083!!<br>\u7d50\u8ad6\u306f\u540c\u3058\u3067\uff0cPCV\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u304b\u5426\u304b\u306f\u3084\u306f\u308aMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u6c7a\u307e\u308b\u305d\u3046\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306e\u534a\u6570\u8fd1\u304f\u304c\uff0c\u5206\u5b50\u8a3a\u65ad\u3067\u81a0\u82bd\u816b\u306b\u5909\u308f\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3057\u3087\u3046\u304b\u3002\u3053\u308c\u304b\u3089\u306f<span style=\"color: #ff0000;\"><strong>\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306a\u3093\u3066\uff0c\u5168\u304f\u4e0d\u8981?<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u306b\u7d50\u8ad6\u3055\u308c\u307e\u3059\u3002<br>\u3058\u3083\u3042\u4eca\u307e\u3067\u306e\u306f\u4f55\u3060\u3093\u3063\u305f\u3093\u3060\uff08\uff1b_\uff1b\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u82f1\u8a9e\u306e\u8ad6\u6587\u3092\u8aad\u3080\u306e\u306b\u3055\u3089\u306b\u6df1\u3044\u77e5\u8b58\u3068\u6ce8\u610f\u529b\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\">\u65e5\u672c\u306b\u304a\u3044\u3066\u306e\u73fe\u5b9f\u554f\u984c<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u907a\u4f1d\u5b50\u8a3a\u65ad\u306f\u65e5\u672c\u3067\u3082\u53ef\u80fd\u3067\u3059<\/li>\n\n\n\n<li>\u3067\u3082\uff0c\u666e\u901a\u306e\u8133\u795e\u7d4c\u5916\u79d1\u533b\u306f\uff0c\u3069\u3053\u3067\u3053\u3093\u306a\u8a3a\u65ad\u3092\u3057\u3066\u3044\u308b\u306e\u304b\u308f\u304b\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u5c02\u9580\u5bb6\u3068\u3044\u3046\u306e\u306f\u6570\u5c11\u306a\u3044\u3057\uff0c\u305d\u3053\u306b\u60a3\u8005\u3055\u3093\u304c\u96c6\u307e\u308b\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u4fdd\u967a\u8a3a\u7642\u3067\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u306e\u3067\uff0c\u60a3\u8005\u3055\u3093\u306b\u6570\u4e07\u5186\u4ee5\u4e0a\u306e\u81ea\u8cbb\u304c\u304b\u304b\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u5165\u9662\u3057\u3066\u624b\u8853\u3057\u3066\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3057\u3066\u3082\uff0c\u81ea\u5df1\u8ca0\u62c5\u306f\u666e\u901a\u306e\u4eba\u30671\u30f6\u6708\u3042\u305f\u308a9\u4e07\u5186\u5f31\u3067\u3059<\/li>\n\n\n\n<li>\u305d\u3053\u306b\u4f59\u5206\u306b\u6570\u4e07\u5186\u4ee5\u4e0a\u306e\u533b\u7642\u8cbb\u304c\u91cd\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u306a\u305c\u52dd\u624b\u306a\u6cbb\u7642\uff0c\u6839\u62e0\u306a\u304d\u6cbb\u7642\u304c\u59cb\u307e\u308b\u306e\u304b<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u3069\u3053\u306b\u3082\u30c7\u30fc\u30bf\u304c\u306a\u3044\u306e\u3067\uff0c\u57fa\u3065\u304f\u6839\u62e0\u306a\u3057<\/li>\n\n\n\n<li>\u3053\u308c\u304b\u3089\u30b9\u30bf\u30fc\u30c8\u3068\u3044\u3046\u308f\u3051\u3067\u3059<\/li>\n\n\n\n<li>\u3060\u304b\u3089\u907a\u4f1d\u5b50\u8a3a\u65ad\uff08\u5206\u5b50\u8a3a\u65ad\uff09\u306b\u57fa\u3065\u3044\u3066\u79c1\u306e\u5927\u5b66\u306f\u3053\u306e\u65b9\u91dd\u3067\u6cbb\u7642\u3092\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u8aac\u660e\u304c\u306a\u3055\u308c\u307e\u3059<\/li>\n\n\n\n<li>\u3082\u3046\u3059\u3067\u306b\u304b\u306a\u308a\u591a\u304f\u306e\u65e5\u672c\u306e\u65bd\u8a2d\u3067\u3053\u306e\u3088\u3046\u306a\u6cbb\u7642\u65b9\u91dd\u304c\u59cb\u307e\u3063\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u73fe\u72b6\u3067\u907a\u4f1d\u8a3a\u65ad\u3092\u3057\u3066\u3082\u60a3\u8005\u3055\u3093\u306b\u30e1\u30ea\u30c3\u30c8\u304c\u5c11\u306a\u3044\u308f\u3051<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6697\u3044\u8a71\u3092\u3059\u308b\u3088\u3046\u3067\u7533\u3057\u8a33\u3042\u308a\u307e\u305b\u3093\u304c\uff0c\u9078\u629e\u80a2\u3068\u306a\u308b\u6cbb\u7642\u65b9\u6cd5\u304c\u306a\u3044\u304b\u3089\u3067\u3059<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u4f7f\u7528\u3067\u304d\u308b\u4fe1\u983c\u3067\u304d\u308b\u6cbb\u7642\u6cd5\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30c0\u30fc\u30eb\u5316\u5b66\u7642\u6cd5\u306e\u307f\u3067\u3059<\/li>\n\n\n\n<li>2014\u5e74\u306b\u30a2\u30d0\u30b9\u30c1\u30f3\u306f\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u3055\u3048\u3067\u304d\u306a\u3044\u3068\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3057\u305f<\/li>\n\n\n\n<li>\u3082\u3061\u308d\u3093\uff0c\u3068\u3066\u3082\u7d30\u304b\u3044\u5fae\u8abf\u6574\u306f\u3067\u304d\u307e\u3059<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u8a3a\u65ad\u306b\u57fa\u3065\u304f\u816b\u760d\u306e\u6cbb\u308a\u3084\u3059\u3055\u306b\u5fdc\u3058\u3066\uff0c\u653e\u5c04\u7dda\u306e\u7167\u5c04\u7bc4\u56f2\u3068\u7dda\u91cf\u3092\u5897\u6e1b\u3057\u305f\u308a\u3059\u308b\u5fae\u8abf\u6574\u3067\u3059<\/li>\n\n\n\n<li>\u307e\u305f\u816b\u760d\u306b\u3088\u3063\u3066\u306f\u30a2\u30d0\u30b9\u30c1\u30f3\u3067\u816b\u760d\u4f53\u7a4d\u3092\u5927\u304d\u304f\u6e1b\u3089\u3059\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b0\u30ea\u30aa\u30fc\u30de\u6cbb\u7642\u306e\u767d\u7d19\u59d4\u4efb\u72b6 <em>carte blanche<\/em> application<\/strong><\/h4>\n\n\n\n<p><em>carte blanche<\/em>\u306f\u30d5\u30e9\u30f3\u30b9\u8a9e\u3067\uff0c\u81ea\u7531\u88c1\u91cf\u3068\u304b\u767d\u7d19\u59d4\u4efb\u72b6\u3068\u304b\u8a33\u3055\u308c\u307e\u3059\u3002\u533b\u5e2b\u6cd5\u306e\u7bc4\u7587\u3067\u306f\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u306f\u8133\u5916\u79d1\u533b\u306b\u767d\u7d19\u59d4\u4efb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u79d1\u5b66\u7684\u306b\u6709\u52b9\u6027\u304c\u8a3c\u660e\u3067\u304d\u3066\u3044\u306a\u3044\u5916\u79d1\u6cbb\u7642\u3082\u533b\u5e2b\u306e\u81ea\u7531\u88c1\u91cf\u3067\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>de Leeuw CN: Supratotal&nbsp;Resection&nbsp;in&nbsp;Glioma: A&nbsp;Systematic&nbsp;Review.&nbsp;Neuro Oncol.&nbsp;2018<br>de Leeuw\u306e\u6279\u8a55\u7684\u306a\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u6d78\u6f64\u6027\u306a\u306e\u3067MRI\u753b\u50cf\u3067\u307f\u3048\u3066\u3044\u308b\u816b\u760d\u3088\u308a\u5e83\u3044\u7bc4\u56f2\u306e\u8133\u307e\u3067\u5207\u9664\u3057\u3066\u3057\u307e\u3048\u3070\uff0c\u518d\u767a\u3059\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u305d\u308c\u3092<span style=\"color: #000080;\"><strong> &#8220;supratotal resection&#8221;<\/strong> <\/span>(\u5468\u308a\u306e\u6b63\u5e38\u306b\u898b\u3048\u308b\u8133\u3082\u5c11\u3057\u53d6\u308b\uff09\u3068\u3044\u3044\u307e\u3059\u3002\u3053\u306e\u8003\u3048\u3067\u624b\u8853\u3092\u3059\u308b\u306e\u306b\uff0c\u899a\u9192\u4e0b\u624b\u8853\uff0cALA\uff0c\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\uff0c\u8853\u4e2dMRI \u306a\u3069\u304c\u5fdc\u7528\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\uff0c\u6700\u65b0\u306e\u8133\u5916\u79d1\u6280\u8853\u3092\u7528\u3044\u3066\u816b\u760d\u304c\u305f\u304f\u3055\u3093\u53d6\u308c\u308b\u3068\u6cbb\u308b\uff08PFS, OS\u306e\u5ef6\u9577\uff09\u3068\u306e\u8ad6\u6587\u3084\u5b66\u4f1a\u767a\u8868\u304c\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u305d\u308c\u3089\u306f\u672c\u5f53\u306b\u6b63\u3057\u3044\u306e\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3059\u3002\u524d\u65b9\u8996\u7684\u306a\u81e8\u5e8a\u8a66\u9a13\u3067\u306a\u3051\u308c\u3070\u8a3c\u660e\u3067\u304d\u306a\u3044\u3053\u3068\u3067\u3059\u3002<br>\u8133\u5916\u79d1\u533b\u3082\u60a3\u8005\u3055\u3093\u3082\uff0c&#8221;supratotal resection&#8221; \u3067\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u6cbb\u305b\u308b\u3068\u4fe1\u3058\u305f\u3044\uff0c\u3068\u3044\u3046\u5e0c\u671b\u306f\u7406\u89e3\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u30e1\u30c1\u30aa\u30cb\u30f3\u30da\u30c3\u30c8 Met-PET<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/metpet.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/metpet-200x200.jpg\" alt=\"\" class=\"wp-image-12762\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/metpet-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/metpet-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><br>11C-\u30e1\u30c1\u30aa\u30cb\u30f3\u3068\u3044\u3046\u653e\u5c04\u6027\u7269\u8cea\u3092\u9759\u8108\u304b\u3089\u6ce8\u5c04\u3057\u3066\uff0c\u8133\u306ePET\uff08\u30dd\u30b8\u30c8\u30ed\u30f3\u65ad\u5c64\u64ae\u5f71\uff09\u3092\u3057\u307e\u3059\u3002\u30e1\u30c1\u30aa\u30cb\u30f3\u306e\u53d6\u308a\u8fbc\u307f\u304c\u9ad8\u3044\u3068\u3053\u308d\u304c\u8d64\u304f\u63cf\u51fa\u3055\u308c\u307e\u3059\u3002\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u708e\u75c7\u6027\u75be\u60a3\u3084\u58ca\u6b7b\u306a\u3069\u3068\u306e\u9451\u5225\u306b\u8ff7\u3063\u305f\u6642\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\uff0c\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u3082\u306e\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u53d6\u308a\u8fbc\u307f\u304c\u9ad8\u304f\u898b\u3089\u308c\u307e\u3059\u304c\uff0c\u75c5\u7406\u8a3a\u65ad\u3092\u8d85\u3048\u308b\u4fa1\u5024\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3092\u898b\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u65b9\u6cd5\u304c\u5909\u308f\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3089\uff0c\u4fdd\u967a\u8a3a\u7642\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u81ea\u5df1\u8ca0\u62c5\u3067\uff16\u4e07\u5186\u4ee5\u4e0a\u306f\u304b\u304b\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u751f\u691c\u8853\uff08\u305b\u3044\u3051\u3093\u3058\u3085\u3064\uff09\u3068\u306f<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u751f\u691c\u8853\u3068\u3044\u3046\u306e\u306f\u816b\u760d\u306e\u307b\u3093\u306e\u4e00\u90e8\u3092\u3061\u3087\u3073\u3063\u3068\u53d6\u3063\u3066\uff0c\u75c5\u7406\u8a3a\u65ad\u3059\u308b\u3053\u3068\u3092\u3044\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u5b9a\u4f4d\u751f\u691c\u8853\u306f\uff0c\u816b\u760d\u306b\u8fd1\u3044\u3068\u3053\u308d\u306e\u982d\u84cb\u9aa8\u306b12mm\u304f\u3089\u3044\u306e\u7a74\u3092\u958b\u3051\u3066\uff0c\u305d\u3053\u304b\u3089\u592a\u3044\u91dd\u307f\u305f\u3044\u306a\u3082\u306e\uff08\u920d\u91dd\uff09\u3092\u8133\u306e\u4e2d\u306b\u305a\u30fc\u3068\u3086\u3063\u304f\u308a\u5dee\u3057\u8fbc\u3093\u3067\uff0c\u816b\u760d\u306e\u304b\u3051\u3089\u3092\u63a1\u3063\u3066\u304f\u308b\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>CT\u3068\u304bMRI\u306e\u753b\u50cf\u3092\u3082\u3068\u306b\u3057\u3066\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u30fb\u30ac\u30a4\u30c9\u3067\u3059\u308b\u306e\u3067\u5834\u6240\u306f\u9593\u9055\u308f\u306a\u3044\u3067\u3059\uff08<span style=\"color: #000080;\"><strong>\u5b9a\u4f4d\u751f\u691c\u8853<\/strong><\/span>\u3068\u3044\u3044\u307e\u3059\uff09<\/li>\n\n\n\n<li>\u8133\u5ba4\u5185\u306b\u7a81\u51fa\u3059\u308b\u816b\u760d\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>\u795e\u7d4c\u5185\u8996\u93e1\u3092\u4f7f\u7528\u3059\u308b\u751f\u691c\u8853 endoscopic biopsy\u00a0<\/strong><\/span>\u3082\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u7c21\u5358\u306a\u5168\u8eab\u9ebb\u9154\u4f75\u7528\u306e\u5c40\u6240\u9ebb\u9154\u3067\u3082\u3067\u304d\u307e\u3059\u304b\u3089\uff0c\u7720\u3063\u3066\u3044\u308b\u3046\u3061\u306b\u77ed\u6642\u9593\u3067\u7d42\u308f\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u3067\u3082\u3057\u304b\u3057\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u75c5\u7406\u8a3a\u65ad\u3092\u9593\u9055\u3044\u3084\u3059\u3044\u306e\u3067\uff0c\u3054\u304f\u5c0f\u3055\u306a\u816b\u760d\u7247\u3060\u3068\u8aa4\u8a3a\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u3067\u3059\u304b\u3089\u9006\u306b\uff0c\u5c0f\u3055\u306a\u958b\u982d\u624b\u8853\u3067\uff0c\u591a\u3081\u306e\u816b\u760d\u7d44\u7e54\u3092\u63a1\u53d6\u3059\u308b\u3068\u3044\u3046\u751f\u691c\u8853\u306e\u65b9\u304c\u8a3a\u65ad\u306f\u6b63\u78ba\u3067\u3059\uff08<strong><span style=\"color: #000080;\">\u958b\u982d\u751f\u691c\u8853<\/span><\/strong>\u3068\u3044\u3044\u307e\u3059\uff09<\/li>\n\n\n\n<li>\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u5fc5\u8981\u3068\u306a\u308a\uff0c\u6df1\u90e8\u306e\u3082\u306e\u3092\u9664\u3051\u3070\uff0c\u958b\u982d\u751f\u691c\u8853\u306e\u307b\u3046\u304c\u591a\u304f\u884c\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u958b\u982d\u751f\u691c\u8853\u306e\u6b20\u70b9\u306f\uff0c\u624b\u8853\u6642\u9593\u304c\u304b\u304b\u308b\u3053\u3068\u3068\uff0c\u50b7\u3092\u5927\u304d\u304f\u3057\u3066\u3057\u307e\u3046\u3068\u6cbb\u308b\u306e\u306b\u6642\u9593\u304c\u304b\u304b\u3063\u3066\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306a\u3069\u306e\u958b\u59cb\u6642\u671f\u304c\u9045\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3053\u3068\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b0\u30ea\u30aa\u30fc\u30de\u6458\u51fa\u624b\u8853\u306e\u539f\u5247\uff1a<\/strong><strong>2017\u5e74\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/strong><\/h4>\n\n\n\n<p>The goal of surgery is to remove as much of the tumour as safely possible to improve neurological function.&nbsp;The prevention of new, permanent neurological deficits is more important than extent of resection as gliomas are not cured by surgery, because tumour cells infiltrate far beyond the lesion and demonstrate network-like growth, both of which are hallmarks of diffuse gliomas.&nbsp;It remains uncertain whether extent of resection truly matters.<br>\u65e5\u672c\u8a9e\u8a33\uff1a\u76ee\u7684\u306f<span style=\"color: #000080;\"><strong>\u8133\u795e\u7d4c\u6a5f\u80fd\u3092\u56de\u5fa9\u3055\u305b\u308b\u305f\u3081\u306b<\/strong><\/span>\uff0c<strong><span style=\"color: #000080;\">\u5b89\u5168\u6027\u3092\u78ba\u4fdd\u3057\u306a\u304c\u3089<\/span><\/strong>\uff0c\u3088\u308a\u591a\u304f\u306e\u816b\u760d\u3092\u6458\u51fa\u3059\u308b\u3053\u3068\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u65b0\u305f\u306a\u3042\u308b\u3044\u306f\u56de\u5fa9\u3057\u306a\u3044\u795e\u7d4c\u8131\u843d\u75c7\u72b6\u3092\u51fa\u3055\u306a\u3044\u3088\u3046\u306b\u624b\u8853\u3059\u308b\u3053\u3068\u304c\uff0c\u3088\u308a\u591a\u304f\u306e\u816b\u760d\u3092\u6458\u51fa\u3059\u308b\u3088\u308a\u3082\u91cd\u8981\u306a\u3053\u3068<\/strong><\/span>\u3067\u3059\u3002\u306a\u305c\u306a\u3089\uff0c\u591a\u304f\u306e<span style=\"color: #000080;\"><strong>\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u5916\u79d1\u624b\u8853\u3060\u3051\u3067\u306f\u6cbb\u3089\u306a\u3044\u75c5\u6c17<\/strong><\/span>\u3060\u304b\u3089\u3067\u3059\u3002\u816b\u760d\u7d30\u80de\u306fMRI\u3067\u307f\u3048\u308b\u9818\u57df\u3092\u8d85\u3048\u3066\u6d78\u6f64\u3057\u3066\u3044\u307e\u3059\u3057\uff0c\u7db2\u306e\u76ee\u306e\u3088\u3046\u306b\u5897\u6b96\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u624b\u8853\u6458\u51fa\u306e\u7a0b\u5ea6\u304c\u771f\u306b\u554f\u984c\u304b\u3069\u3046\u304b\u306f\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3082\u3061\u308d\u3093\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u5148\u9032\u56fd\u3067\uff0c\u4e0b\u306b\u66f8\u3044\u3066\u3042\u308b\u3088\u3046\u306a\u6700\u65b0\u306e\u5916\u79d1\u6280\u8853\u3092\u99c6\u4f7f\u3057\u305f\u4e0a\u3067\uff0c\u3055\u3089\u306b\u91cd\u8981\u306a\u539f\u5247\u3068\u3057\u3066\u8a18\u8ff0\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u624b\u8853\u3067\u7528\u3044\u3089\u308c\u308b\u3082\u306e<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e00\u822c\u7684\u306b\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u624b\u8853\u3067\u5b8c\u5168\u6458\u51fa\u3059\u308c\u3070\u6cbb\u308b\u3068\u3044\u3046\u539f\u5247\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u3067\u3082\u5b8c\u5168\u6458\u51fa\u3092\u3067\u304d\u308b\u4f8b\u306f\u591a\u304f\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u5c11\u3057\u3067\u3082\u591a\u304f\u6458\u51fa\u3057\u305f\u307b\u3046\u304c\uff0c\u5143\u6c17\u306b\u66ae\u3089\u305b\u308b\u671f\u9593\u304c\u9577\u304f\u306a\u308b PFS\uff0c\u751f\u5b58\u671f\u9593\u304c\u9577\u304f\u306a\u308b OS\u3068\u3044\u3046\u539f\u5247\u3082\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u3067\u3082\u624b\u8853\u3060\u3051\u3067\u6cbb\u3089\u306a\u3044\u3082\u306e\u3082\u305f\u304f\u3055\u3093\u3042\u308b\u306e\u3067\uff0c\u969c\u5bb3\u3092\u51fa\u3057\u3066\u307e\u3067\u7121\u7406\u3057\u3066\u6458\u51fa\u3057\u306a\u3044\u3068\u3044\u3046\u65b9\u91dd\u304c\u9078\u629e\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3057\u3087\u3046<\/li>\n\n\n\n<li><span style=\"color: #000000;\">\u624b\u8853\u3067\u7528\u3044\u3089\u308c\u308b<\/span>\u3082\u3063\u3068\u91cd\u8981\u306a\u624b\u6cd5\u3068\u3057\u3066\uff0c<span style=\"color: #ff0000;\"><strong>\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\uff0c\u8853\u4e2d iMRI\uff0cMEP\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff0c\u6a5f\u80fd\u7684MRI\u753b\u50cf (functional MRI)\u306b\u3088\u308b\u904b\u52d5\u91ce\u30fb\u8a00\u8a9e\u91ce\u306e\u540c\u5b9a\uff0cDTI-FT\u306b\u3088\u308b\u9310\u4f53\u8def\u30fb\u8996\u8def\u306e\u540c\u5b9a\uff0cMEG\u306b\u3088\u308b\u512a\u4f4d\u534a\u7403\u6c7a\u5b9a\uff0cSEP\u306b\u3088\u308b\u4e00\u6b21\u611f\u899a\u91ce\u30fb\u4e2d\u5fc3\u6e9d\u540c\u5b9a\uff0c\u899a\u9192\u4e0b\u624b\u8853<\/strong><\/span>\u306a\u3069\u3044\u308d\u3044\u308d\u306a\u6280\u8853\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u3067\u3082\u3053\u308c\u3089\u3082\u5e38\u6642\u3067\u306f\u306a\u304f\uff0c\u3042\u304f\u307e\u3067\u3082<span style=\"color: #000080;\"><strong>\u6642\u306b\u306f\u6709\u7528<\/strong><\/span>\u3068\u3044\u3046\u3082\u306e\u3067\u3059<\/span><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u3044\u305a\u308c\u3082\u5168\u304f\u975e\u4fb5\u8972\u7684\uff08\u884c\u3046\u3053\u3068\u306b\u3088\u3063\u3066\u5bb3\u304c\u306a\u3044\uff09\u3068\u3044\u3046\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u305d\u308c\u305e\u308c\u306b\u526f\u4f5c\u7528\uff08\u5408\u4f75\u75c7\uff09\u3082\u3042\u308a\uff0c\u304a\u91d1\u3082\u304b\u304b\u308a\uff0c\u8853\u524d\u691c\u67fb\u3068\u624b\u8853\u6642\u9593\u304c\u9577\u304f\u306a\u308a\uff0c\u3055\u307e\u3056\u307e\u306a\u554f\u984c\u304c\u3042\u308b\u3082\u306e\u3067\u3059<\/span><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u7279\u306b\u554f\u984c\u304c\u591a\u3044\u306e\u306f\u899a\u9192\u4e0b\u624b\u8853\u3067\u3059\uff0c\u3042\u307e\u308a\u306b\u3082\u6839\u62e0\u306a\u3044\u4f8b\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059<\/span><\/li>\n\n\n\n<li>\u5de6\u524d\u982d\u8449\u306e\u8a00\u8a9e\u91ce\u306a\u3069\uff0c\u899a\u9192\u4e0b\u624b\u8853\u306e\u5229\u70b9\u304c\u304b\u306a\u308a\u671f\u5f85\u3067\u304d\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u9650\u5b9a\u7684\u306b\u7528\u3044\u3089\u308c\u308b\u3079\u304d\u3067\u3059<\/li>\n\n\n\n<li>\u899a\u9192\u4e0b\u624b\u8853\u3067\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306e20%\u304f\u3089\u3044\u3092\u6458\u51fa\u3055\u308c\u3066\u3044\u308b\u8853\u5f8c\u306e\u60a3\u8005\u3055\u3093\u3092\u307f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u306a\u3093\u306e\u305f\u3081\u306b\u899a\u9192\u4e0b\u624b\u8853\u3092\u3057\u305f\u306e\u304b\u3055\u3063\u3071\u308a\u7406\u89e3\u304c\u3067\u304d\u307e\u305b\u3093<\/li>\n\n\n\n<li><span style=\"color: #000000;\"><span style=\"color: #000080;\"><strong>\u5c0f\u5150\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u899a\u9192\u4e0b\u624b\u8853\u3092\u7a4d\u6975\u7684\u306b\u884c\u3046\u3068\u3044\u3046\u3053\u3068\u306b\u306f\uff0c\u502b\u7406\u7684\u306a\u554f\u984c<\/strong><\/span>\u3082\u3042\u308a\u307e\u3059<\/span><\/li>\n\n\n\n<li>\u3066\u3093\u304b\u3093\u306e\u7126\u70b9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u3044\u3046\u76ee\u7684\u3067\u306e\uff0c<span style=\"color: #000080;\"><strong>\u786c\u819c\u5916\u96fb\u6975\u306e\u57cb\u3081\u8fbc\u307f\u306e\u305f\u3081\u306b\u958b\u982d\u624b\u8853<\/strong><\/span>\u3092\u52e7\u3081\u3089\u308c\u305f\u6642\u3082\u62d2\u5426\u3057\u305f\u65b9\u304c\u3044\u3044\u3067\u3059\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u3068\u306f\u306a\u3093\u306e\u95a2\u308f\u308a\u3082\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u57f7\u5200\u533b\u306e\u7d4c\u9a13\u3068\u6280\u8853\u306b\u88cf\u6253\u3061\u3055\u308c\u3066\u3044\u3066\uff0c\u4f7f\u7528\u3057\u306a\u3044\u3067\u6e08\u3080\u306e\u3067\u3042\u308c\u3070\u305d\u306e\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/span><\/li>\n\n\n\n<li><span style=\"color: #333333;\">\u305d\u3082\u305d\u3082\u89e3\u5256\u751f\u7406\u5b66\u7684\u306b\u53d6\u308c\u306a\u3044\u4f4d\u7f6e\u306b\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u306f\uff0c\u899a\u9192\u4e0b\u624b\u8853\u3067\u3082\uff0c\u8853\u4e2dMRI\u3067\u3082ALA\u3067\u53ef\u8996\u5316\u3067\u304d\u3066\u3082\uff0c\u751f\u7406\u5b66\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u3057\u3066\u3082\u6458\u51fa\u3067\u304d\u307e\u305b\u3093<\/span><\/li>\n\n\n\n<li>\u3061\u306a\u307f\u306b\u79c1\u306f\uff0cALA\u3082\u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u3082\u4f7f\u7528\u3057\u3066\u3044\u307e\u3059\u3057\uff0c\u899a\u9192\u4e0b\u624b\u8853\u3082\u7d4c\u9a13\u3057\u3066\u3044\u307e\u3059\uff0cMEP\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff0c\u6a5f\u80fd\u7684MRI\u753b\u50cf\u306b\u3088\u308b\u904b\u52d5\u91ce\u30fb\u8a00\u8a9e\u91ce\u306e\u540c\u5b9a\uff0cDTI-FT\u306b\u3088\u308b\u9310\u4f53\u8def\u30fb\u8996\u8def\u306e\u540c\u5b9a\uff0cMEG\u306b\u3088\u308b\u512a\u4f4d\u534a\u7403\u6c7a\u5b9a\uff0cSEP\u306b\u3088\u308b\u4e00\u6b21\u611f\u899a\u91ce\u30fb\u4e2d\u5fc3\u6e9d\u540c\u5b9a\uff0c\u8853\u4e2d\u306e\u8868\u9762\u6df1\u90e8\u8133\u6ce2\u30e2\u30cb\u30bf\u30fc\u3082\u5168\u90e8\u3057\u305f\u3053\u3068\u3042\u308a\u307e\u3059\u3000o(^o^)o<\/li>\n\n\n\n<li>\u5fdc\u7528\u3067\u304d\u3066\u4fa1\u5024\u306e\u3042\u308b\u624b\u6bb5\u306f\u5229\u7528\u3057\u307e\u3059\u304c\uff0c\u3053\u308c\u304c\u3042\u308c\u3070\u751f\u5b58\u7387\u304c\u4e0a\u304c\u308b\u3068\u3044\u3046\u8003\u3048\u65b9\u306f\u3057\u307e\u305b\u3093<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u624b\u8853\u5f8c\u306eMRI\u8a55\u4fa1<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6458\u51fa\u3092\u6b63\u78ba\u306b\u628a\u63e1\u3059\u308b\u305f\u3081\u306b\u306f\uff0c\u624b\u8853\u5f8c\u3067\u304d\u305f\u308924\u6642\u9593\u3082\u3057\u304f\u306f48\u6642\u9593\u4ee5\u5185\u306bMRI\u3092\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u5fc5\u8981\u304c\u3042\u308c\u3070\u30ac\u30c9\u30ea\u30cb\u30e0\u5897\u5f37MRI\u3068\u62e1\u6563\u5f37\u8abf\u753b\u50cf DWI\u3092\u64ae\u5f71\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u4e3b\u305f\u308b\u7406\u7531\u306f\uff0c\u6b8b\u5b58\u816b\u760d\u306e\u5927\u304d\u3055\u3068\uff0c\u624b\u8853\u306b\u3088\u308b\u6458\u51fa\u8154\u5468\u56f2\u306e\u865a\u8840\u75c5\u5de3\u306e\u5e83\u304c\u308a\u3092\u628a\u63e1\u3057\u3066\u304a\u304f\u305f\u3081\u3067\u3059<\/li>\n\n\n\n<li>\u624b\u8853\u304c\u5348\u5f8c\u306b\u7d42\u308f\u308b\u6642\u304c\u591a\u3044\u306e\u3067\uff0c\u7fcc\u65e5\u306e\u5348\u5f8c\u306bMRI\u3092\u3059\u308b\u304b\uff0c2\u65e5\u5f8c\u306bMRI\u3092\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #000080;\"><a href=\"\/sawamura\/braintumors\/radiation\/\">\u653e\u5c04\u7dda\u6cbb\u7642\uff08\u8a73\u3057\u3044\u5185\u5bb9\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u76ee\u7684\u306f\uff0c\u751f\u6d3b\u306e\u8cea\u3092\u4fdd\u3063\u3066\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u3044\u3064\u884c\u3046\u304b timing\uff0c\u3069\u306e\u7a0b\u5ea6\u306e\u7dda\u91cf\u3092\u4f7f\u3046\u304b dosing\uff0c\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb scheduling\u3092\u6c7a\u3081\u307e\u3059<\/li>\n\n\n\n<li>\u75c5\u7406\u8a3a\u65ad\uff0c\u4e88\u5f8c\u63a8\u5b9a\uff0c\u5e74\u9f62\uff0cKPS\uff08\u4e00\u822c\u72b6\u614b\uff09\uff0c\u5916\u79d1\u6458\u51fa\u5ea6\u304c\u5224\u65ad\u57fa\u6e96\u3068\u306a\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u624b\u8853\u5f8c\u306b\u884c\u3046\u5834\u5408\u306f3\u22125\u9031\u9593\u4ee5\u5185\u306b\u958b\u59cb\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u6a19\u6e96\u7684\u306b\u306f\uff0c\u5c40\u6240\u7167\u5c04\u306750-60\u30b0\u30ec\u30a4\uff0c1\u65e5\u7dda\u91cf 1.8-2.0\u30b0\u30ec\u30a4\u3067\u3059<\/li>\n\n\n\n<li>\u4e88\u5f8c\u306e\u60aa\u3044\u60a3\u8005\u3055\u3093\u3084\u9ad8\u9f62\u8005\u306b\u306f\uff0c\u56de\u6570\u3092\u5c11\u306a\u304f\u3057\u3066\u7dda\u91cf\u3092\u3042\u3052\u308b\u4f4e\u5206\u5272\u7167\u5c04\u304c\u7528\u3044\u3089\u308c\u307e\u3059\uff0c\u305f\u3068\u3048\u30701\u65e52.67\u30b0\u30ec\u30a4\u309215\u56de\u306b\u5206\u3051\u3066\u6cbb\u7642\u3059\u308b\u306a\u3069\u3067\u3059<\/li>\n\n\n\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u6d78\u6f64\u6027\u306e\u816b\u760d\u3067\u3059\u304b\u3089\uff0cMRI T2\/FLAIR \u3067\u307f\u3048\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u75c5\u5909\u304b\u30891cm\u3042\u308b\u3044\u306f2.5cm\u304f\u3089\u3044\u96e2\u308c\u305f\u3068\u3053\u308d\u307e\u3067\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u7bc4\u56f2 CTV clinical target volume \u306b\u542b\u3081\u307e\u3059<\/li>\n\n\n\n<li>\u3069\u306e\u304f\u3089\u3044\u96e2\u308c\u305f\u3068\u3053\u308d\u307e\u3067\u7167\u5c04\u9818\u57df\u306b\u542b\u3081\u308b\u304b\u3068\u3044\u3046\u3053\u3068\u306f\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60aa\u6027\u5ea6\u3068\u75c5\u7406\u8a3a\u65ad\u3092\u8e0f\u307e\u3048\u3066\u6c7a\u3081\u307e\u3059\uff0c\u81a0\u82bd\u816b\u3067\u3042\u308c\u30702.5cm\u306f\u6b32\u3057\u3044<\/li>\n\n\n\n<li>\u30de\u30fc\u30b8\u30f3\u3092\u542b\u3081\u308b\u3068\u3044\u3046\u306e\u3067\u3059\u304c\uff0c\u6cbb\u7642\u8a08\u753b\u3059\u308b\u3068\u3053\u308c\u304c\u304b\u306a\u308a\u5e83\u3044\u7bc4\u56f2\u306b\u306a\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u8a08\u753b\u306f\u3068\u3066\u3082\u8907\u96d1\u3067\u96e3\u3057\u3044\u306e\u3067\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u306b\u6163\u308c\u305f\u653e\u5c04\u7dda\u6cbb\u7642\u533b\u304c\u884c\u3044\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u85ac<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong><span style=\"color: #000080;\"><a href=\"\/sawamura\/braintumors\/glioma\/temozolo\/\" title=\"\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff09\">\u30c6\u30e2\u30c0\u30fc\u30eb\uff08\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff09<\/a>\uff0c<a href=\"\/sawamura\/braintumors\/glioma\/avastine\/\" title=\"\u30a2\u30d0\u30b9\u30c1\u30f3\">\u30a2\u30d0\u30b9\u30c1\u30f3\uff08\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff09<\/a>\uff0c<a href=\"\/sawamura\/braintumors\/glioma\/gliadel\/\" title=\"\u30ae\u30ea\u30a2\u30c7\u30eb\">\u30ae\u30ea\u30a2\u30c7\u30eb\uff08\u30b0\u30ea\u30a2\u30c7\u30eb<\/a><\/span><a href=\"\/sawamura\/braintumors\/glioma\/gliadel\/\" title=\"\u30ae\u30ea\u30a2\u30c7\u30eb\">\uff09<\/a><\/strong>\u306a\u3069\u306e\u6297\u304c\u3093\u5264\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u540d\u524d\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u898b\u308c\u307e\u3059\uff09<\/li>\n\n\n\n<li><strong><span style=\"color: #000080;\">\u6700\u3082\u6709\u52b9\u6027\u304c\u9ad8\u3044\u306e\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u7d4c\u53e3\u85ac\uff09<\/span><\/strong><span style=\"color: #333333;\">\u3067\u3059<\/span><\/li>\n\n\n\n<li>2023\u5e74\u306b\uff0c<span style=\"color: #000080;\"><strong>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u00a0vorasidenib\uff08\u7d4c\u53e3\u85ac\uff09<\/strong><\/span>\u306eIDH\u5909\u7570\u578b\u30b0\u30ea\u30aa\u30fc\u30de\u3078\u306e\u6709\u52b9\u6027\u304c\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u3067\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f<\/li>\n\n\n\n<li>CCNU\uff08\u30ed\u30e0\u30b9\u30c1\u30f3\uff09\uff0cACNU\uff08\u30cb\u30c9\u30e9\u30f3\uff0c\u30cb\u30e0\u30b9\u30c1\u30f3\uff09\uff0cBCNU\uff08\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3\uff09\uff0cFTM\uff08\u30d5\u30a9\u30c6\u30e0\u30b9\u30c1\u30f3\uff09\u306a\u3069\u306e\u30cb\u30c8\u30ed\u30bd\u30a6\u30ec\u30a2\u7cfb\u85ac\u5264\u306f\u30bb\u30ab\u30f3\u30c9\u30e9\u30a4\u30f3\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u307e\u3059<\/li>\n\n\n\n<li>\u65e5\u672c\u3067\u306f\u30cb\u30c9\u30e9\u30f3\u3060\u3051\u304c\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u3048\u307e\u3059<\/li>\n\n\n\n<li>\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306f\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u5168\u822c\u306bPCV\u5316\u5b66\u7642\u6cd5\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u304c\uff0c\u65e5\u672c\u3067\u306f\u4f7f\u3048\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u30ed\u30e0\u30b9\u30c1\u30f3\u306f\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6709\u52b9\u3067\u3059\u304c\u30cd\u30c3\u30c8\u901a\u8ca9\u3067\u8cb7\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\uff0c\u4f7f\u7528\u306f\u6df7\u5408\u8a3a\u7642\u3068\u306a\u308b\u306e\u3067\u533b\u5e2b\u306e\u5354\u529b\u304c\u5f97\u3089\u308c\u305a\uff0c\u73fe\u5b9f\u7684\u306b\u306f\u4f7f\u3048\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u30aa\u30d6\u30b8\u30fc\u30dc\uff08\u30cb\u30dc\u30eb\u30de\u30d6\uff09\u306f\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\u52b9\u304d\u307e\u305b\u3093\uff0c\u3057\u304b\u3082\u5e74\u9593\u30672000\u4e07\u5186\u304f\u3089\u3044\u304b\u304b\u308a\u307e\u3059\u304b\u3089\u4f7f\u308f\u306a\u3044<\/li>\n\n\n\n<li><strong><span style=\"color: #000080;\">BRAF\u963b\u5bb3\u5264\u306e\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\uff08\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6)\u3068\u30e1\u30ad\u30cb\u30b9\u30c8\uff08\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff09\u306e\u4f75\u7528\u6295\u4e0e\u304c\u4fdd\u967a\u8a3a\u7642\u3067\u3067\u304d\u307e\u3059<\/span><\/strong><\/li>\n\n\n\n<li><span style=\"color: #333333;\">BRAF v600\u907a\u4f1d\u5b50\u306b\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\u5f93\u6765\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u306e\u3082\u306e\u306b\uff0c<\/span><strong><span style=\"color: #000080;\">\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\u30ab\u30d7\u30bb\u30eb\uff08<\/span><\/strong><strong style=\"color: #000080;\">\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\uff0cBRAF\u963b\u5bb3\u5264\uff09\uff0c\u30e1\u30ad\u30cb\u30b9\u30c8\u9320\uff08<\/strong><strong style=\"color: #000080;\">\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff0cMEK\u963b\u5bb3\u5264\uff09<\/strong><span style=\"color: #333333;\">\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3082\u306e\u3067\u3059<\/span><\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\">\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60aa\u6027\u8ee2\u5316 malignant transformation<br>\u30bb\u30ab\u30f3\u30c0\u30ea\u30fc\u30fb\u30b0\u30ea\u30aa\u30d6\u30e9\u30b9\u30c8\u30fc\u30de<\/h1>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3057\u3066\u518d\u71c3\uff08\u518d\u767a\uff09\u3059\u308b\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u60aa\u6027\u8ee2\u5316\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3082\u3068\u3082\u3068\u30b0\u30ec\u30fc\u30c92\u3067\u3082\u60aa\u6027\u816b\u760d\u306a\u306e\u3067\uff0c\u826f\u6027\u306e\u3082\u306e\u304c\u60aa\u6027\u306b\u306a\u3063\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u5358\u306b\u518d\u71c3\u6642\u306b\u30b0\u30ec\u30fc\u30c9\u304c\u4e0a\u304c\u308b\u3068\u7406\u89e3\u3057\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n\n\n\n<li>\u75c5\u7406\u5b66\u7684\u306b\u306f\uff0c\u3082\u3068\u3082\u3068\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u304c\uff0c\u521d\u56de\u8a3a\u65ad\u3067\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3057\u3066\u8aa4\u8a3a\u3055\u308c\u305f\u306e\u307f\u3067\uff0c\u7279\u306b\u907a\u4f1d\u5b50\u5909\u7570 transformation \u3057\u305f\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u7406\u89e3\u3055\u308c\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3059<\/li>\n\n\n\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3068\u816b\u760d\u304c\u60aa\u6027\u5316\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u3088\u304f\u8a00\u308f\u308c\u307e\u3059\u304c\uff0c\u305d\u3046\u3067\u306f\u306a\u3044\u5834\u5408\u304c\u307b\u3068\u3093\u3069\u3067\u3059<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u3044\u304f\u3064\u304b\u306e\u4ee3\u8868\u7684\u306a\u518d\u767a\u30d1\u30bf\u30fc\u30f3\u304c\u3042\u308a\u307e\u3059<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u30b0\u30ec\u30fc\u30c92\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u304c\uff0c\u77ed\u671f\u9593\u306e\u9593\u306b\u30b0\u30ec\u30fc\u30c94\u81a0\u82bd\u816b\u3068\u3057\u3066\u518d\u767a\u3059\u308b<\/li>\n\n\n\n<li>\u30b0\u30ec\u30fc\u30c93\u306e\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u304c\uff0c\u4f55\u5e74\u304b\u5f8c\u306b\u30b0\u30ec\u30fc\u30c94\u306e\u81a0\u82bd\u816b\u3068\u3057\u3066\u518d\u767a\u3059\u308b<\/li>\n\n\n\n<li>\u30b0\u30ec\u30fc\u30c92\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\uff0c\u4f55\u5e74\u3082\u5f8c\u3067\u30b0\u30ec\u30fc\u30c93\u306e\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3057\u3066\u518d\u767a\u3059\u308b<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\">\u3082\u3063\u3068\u3082\u6c17\u3092\u3064\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u5206\u5b50\u8a3a\u65ad<\/h4>\n\n\n\n<p><span style=\"color: #000080;\"><strong>IDH wild-type \u91ce\u751f\u578b\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c92\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408<\/strong><\/span>\u3067\u3059\uff0c\u3053\u306e\u30bf\u30a4\u30d7\u306f\uff0c\u65e9\u671f\u306b\u81a0\u82bd\u816b\u3068\u3057\u3066\u518d\u71c3\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c93\u306e\u81a0\u82bd\u816b\u3068\u3057\u3066\u306e\u518d\u767a\u4f8b<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1-300x300.jpg\" alt=\"\" class=\"wp-image-10986\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1-550x552.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk1.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk2.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"294\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk2-294x300.jpg\" alt=\"\" class=\"wp-image-10987\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk2-294x300.jpg 294w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk2-550x562.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk2.jpg 709w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<p>\u5de6\u4e0a\u524d\u982d\u56de\u306e\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de diffuse glioma \u3067\u3059\u3002\u624b\u8853\u3067\u307b\u307c\u5168\u6458 gross total removal\u3057\u306654\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u3092\u3057\u307e\u3057\u305f\u3002\u75c5\u7406\u8a3a\u65ad\u306f\uff0coilg 2\u967d\u6027\uff0c<span style=\"color: #000080;\"><strong>1p\/19q\u67d3\u8272\u4f53\u306e\u6b20\u5931\u306f\u306a\u3044<\/strong><strong>\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c93<\/strong><\/span>\u3068\u3055\u308c\u307e\u3057\u305f\u3002\u5168\u4f53\u7684\u306b\u306f\u30b0\u30ec\u30fc\u30c92\u3067\u3042\u308b\u3068\u306e\u75c5\u7406\u533b\u306e\u610f\u898b\u3082\u3042\u308a\u307e\u3057\u305f\u3057\uff0c\u5f53\u6642\u306f\u5317\u5927\u75c5\u9662\u3067\u3082IDH\u306e\u6b63\u78ba\u306a\u5206\u5b50\u75c5\u7406\u8a3a\u65ad\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"285\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk3-285x300.jpg\" alt=\"\" class=\"wp-image-10988\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk3-285x300.jpg 285w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk3-550x579.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk3.jpg 709w\" sizes=\"auto, (max-width: 285px) 100vw, 285px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk4.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"280\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk4-280x300.jpg\" alt=\"\" class=\"wp-image-10989\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk4-280x300.jpg 280w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk4-550x589.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk4.jpg 709w\" sizes=\"auto, (max-width: 280px) 100vw, 280px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<p>5\u5e74\u5f8c\u3067\u3059\u3002\u4e0a\u524d\u982d\u56de\u306e\u75c5\u5de3\u306f\u843d\u3061\u7740\u3044\u3066\u3044\u307e\u3057\u305f\u304c\uff0c\u521d\u56de\u306b\u306f\u306a\u304b\u3063\u305f\u306f\u305a\u306e\u5834\u6240\uff0c\u8133\u6881\u524d\u65b9\u306b\u6025\u6fc0\u306a\u518d\u767a\u5897\u5927\u3092\u751f\u3058\u307e\u3057\u305f\u3002\u307e\u305f\u624b\u8853\u3067\u5168\u6458\u51fa gross total removal\u3057\u3066\uff0c\u304b\u306a\u308a\u7d5e\u3063\u305f\u9818\u57df\u306b60\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff0c\u30a2\u30d0\u30b9\u30c1\u30f3\u306e\u6295\u4e0e\u3092\u3057\u307e\u3057\u305f\u3002\u75c5\u7406\u8a3a\u65ad\u306f\uff0c<span style=\"color: #000080;\"><strong>IDH wild-tpye, 1p\/19q non-codel, &nbsp;MIB 40%, ATRX positive, MGMT negative\u306e\u81a0\u82bd\u816b<\/strong><\/span>\u3067\u3057\u305f\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6-300x300.jpg\" alt=\"\" class=\"wp-image-10991\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6-550x551.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk6.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk5.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"286\" height=\"300\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk5-286x300.jpg\" alt=\"\" class=\"wp-image-10990\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk5-286x300.jpg 286w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk5-550x578.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2018\/06\/transformnk5.jpg 709w\" sizes=\"auto, (max-width: 286px) 100vw, 286px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u306e\u5f8c\u307e\u305f\u3057\u3070\u3089\u304f\u5bdb\u89e3\u7d99\u7d9a\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u3068\u4e0d\u660e\u306a\u3053\u3068<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>oligo\u3068\u3057\u3066\u306e\u5206\u5316\u50cf\u3092\u542b\u3080AA anaplastic astrocytoma\u304c\uff0c\u518d\u767a\u6642\u306bGBM\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u4e8b\u5b9f\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u3053\u308c\u306f\u6700\u521d\u304b\u3089\u5358\u306a\u308bGBM\u3067\u3042\u3063\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>oligo\u306e\u90e8\u5206\u50cf\u3092\u304b\u306a\u308a\u542b\u3080\uff0c\u30b0\u30ec\u30fc\u30c93\u3042\u308b\u3044\u306f2\u306e diffuse glioma\u3067\u3057\u305f\u304c\uff0c1p\/19q\u306e\u6b20\u5931\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f<\/li>\n\n\n\n<li>secondary GBM\u306e\u3088\u3046\u306b\uff0c\u6cbb\u7642\u53cd\u5fdc\u6027\u304c\u3088\u3044\u3082\u306e\u3067\u3057\u305f\u304c\uff0c\u518d\u767a\u6642\u306b\u306fIDH\u306fwild type\u3067\u3057\u305f<\/li>\n\n\n\n<li>\u518d\u767a\u306f\u521d\u767a\u90e8\u4f4d\u3068\u306f\u304b\u306a\u308a\u96e2\u308c\u305f\u90e8\u4f4d\u3067\uff0c\u653e\u5c04\u7dda\u7dda\u91cf\u304c\u307b\u3068\u3093\u3069\u5165\u3063\u3066\u3044\u306a\u3044\u90e8\u4f4d\u3067\u3057\u305f<\/li>\n\n\n\n<li>\u3053\u308c\u3092\u653e\u5c04\u7dda\u8a98\u767aGBM\u3068\u3057\u3066\u6349\u3048\u308b\u306e\u304b\u3069\u3046\u304b\u4e0d\u660e\u3067\u3059<\/li>\n\n\n\n<li>\u9006\u306b\uff0cCTV\u306f\u304b\u306a\u308a\u5e83\u304f\u3068\u3066\u3042\u3063\u305f\u306e\u3067\u653e\u5c04\u7dda\u306e\u639b\u3051\u640d\u306a\u3044\u3067\u306e\u518d\u767a\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u4e88\u60f3\u4ee5\u4e0a\u306b\u304b\u306a\u308a\u5e83\u304f\u6d78\u6f64\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\">\u3053\u3053\u304b\u3089\u4e0b\u306f\u96e3\u3057\u3044\u3067\u3059<\/h1>\n\n\n\n<h4 class=\"wp-block-heading\"><a href=\"\/sawamura\/glioma\/gliomamoleculardiag\/\">\u81e8\u5e8a\u533b\u306e\u305f\u3081\u306e\u5206\u304b\u308a\u3084\u3059\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u907a\u4f1d\u5b50\u8a3a\u65ad\uff1a\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><br>\uff082021\u5e74\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u57fa\u6e96\uff09<\/h4>\n\n\n\n<div style=\"padding-left: 30px;\"><hr><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #003366;\"><strong>\u767a\u751f\u90e8\u4f4d\u306b\u3088\u3063\u3066\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u308b\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/pediattumor\/brainstemglioma\/\" title=\"\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\uff0c\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\uff0c\u6a4b\u81a0\u816b\uff09\">\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de brainstem glioma<\/a><\/strong><\/span><\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/pediattumor\/opticpathwaypil\/\" title=\"\u8996\u795e\u7d4c\u81a0\u816b\uff0c\u8996\u8def\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b optic pathway glioma\">\u8996\u795e\u7d4c\u81a0\u816b optic glioma<\/a><\/strong><\/span><\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/tectal-glioma\/\" title=\"\u4e2d\u8133\u8996\u84cb\u30b0\u30ea\u30aa\u30fc\u30de tectal glioma, tectal plate glioma\">\u4e2d\u8133\u8996\u84cb\u30b0\u30ea\u30aa\u30fc\u30de tectal plate glioma<\/a><\/strong><\/span><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #000080;\"><strong>\u8a3a\u65ad\u3067\u306f\uff0cLow-grade glioma<\/strong>\u3068\u3044\u3046\u8a00\u8449\u306f\u306a\u308b\u3079\u304f\u4f7f\u308f\u306a\u3044<\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de low-grade glioma\u3068\u3044\u3046\u7528\u8a9e\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3084\u661f\u7d30\u80de\u816b\u3084\u4e4f\u7a81\u8d77\u81a0\u816b\u306a\u3069\u306e\u30b0\u30ec\u30fc\u30c91\u3068\u30b0\u30ec\u30fc\u30c92\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u793a\u3057\u307e\u3059\u304c\uff0c\u3053\u308c\u3082\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u7528\u8a9e\u3068\u540c\u3058\u3067\u610f\u5473\u3092\u306a\u3057\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u8a3a\u65ad\u6642\u306blow-grade glioma\u3092\u7591\u3046\u3068\u3044\u3046\u30b3\u30e1\u30f3\u30c8\u306f\u4f7f\u7528\u3057\u3066\u3088\u3044\u3067\u3057\u3087\u3046\uff0c\u3057\u304b\u3057\uff0c\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u3081\u308b\u6642\u306b\u306f\u4f7f\u7528\u3057\u3066\u306f\u306a\u308a\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u4f55\u6545\u306a\u3089\u3001\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c9\uff12\u3068\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3067\u306f\u6cbb\u7642\u65b9\u91dd\u304c\u5168\u304f\u7570\u306a\u308b\u304b\u3089\u3067\u3059<\/li>\n\n\n\n<li>\u3053\u308c\u3089\u3092\u4e00\u7dd2\u304f\u305f\u306b\u3057\u3066\uff0c\u6642\u306b\u306f\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u3082\u542b\u3081\u3066low-grade glioma\u3068\u3057\u3066\u6cbb\u7642\u3057\u3066\u3044\u308b\u5c0f\u5150\u79d1\u306e\u5148\u751f\u304c\u3044\u307e\u3059\u304c\uff0c\u305d\u308c\u306f\u5927\u304d\u306a\u8aa4\u308a\u3067\u3059<\/li>\n\n\n\n<li>\u75c5\u7406\u7d44\u7e54\u304c\u5206\u985e\u3055\u308c\u3066\u3044\u306a\u3044low-grade glioma\u306e\u624b\u8853\u6210\u7e3e\u3084\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u306e\u8ad6\u6587\u5831\u544a\u3082\u8aad\u307e\u306a\u3044\u65b9\u304c\u3088\u3044\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u306f\u751f\u5b58\u671f\u9593\u3060\u3051\u3067\u306f\u306a\u3044<br>\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u6cbb\u7642\u306e&nbsp;<span style=\"color: #ff0000;\">oncofunctional balance<\/span><\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\uff0c\u751f\u5b58\u671f\u9593\u306e\u512a\u52a3\u306e\u307f\u3067\u6cbb\u7642\u65b9\u6cd5\u3092\u9078\u629e\u3057\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/li>\n\n\n\n<li>\u300c\u547d\u6c38\u3089\u3048\u308b\u3053\u3068\u300d\u3068\u300c\u6cbb\u7642\u5f8c\u306e\u751f\u6d3b\u306e\u8cea QOL\u300d\u306f\u540c\u7b49\u306b\u91cd\u8981\u306a\u5224\u65ad\u6750\u6599\u3067\u3059<\/li>\n\n\n\n<li>QOL\u306f\u624b\u8db3\u306e\u9ebb\u75fa\u306a\u3069\u304c\u91cd\u8981\u8996\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u7279\u306b\u91cd\u8981\u306a\u306e\u306f\uff0c\u8a8d\u77e5\u6a5f\u80fd\uff08\u77e5\u80fd\uff0c\u4eba\u683c\u306a\u3069\uff09\u3092\u60aa\u304f\u3057\u306a\u3044\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u5f8c\u306b\uff0c\u300c<span style=\"color: #000080;\"><strong>\u793e\u4f1a\u5fa9\u5e30\u3067\u304d\u308b\u7a0b\u5ea6\u306e\u6cbb\u7642\u4fb5\u8972<\/strong><\/span>\u300d\u306e\u307f\u304c\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u9078\u629e\u80a2\u3068\u306a\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u5b66\u6821\u3084\u8077\u5834\u306b\u623b\u308c\u306a\u3044\u3088\u3046\u306a\uff0c\u7a4d\u6975\u7684\u306a\u624b\u8853\u3084\u5f37\u3044\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u3057\u307e\u305b\u3093<\/li>\n\n\n\n<li><span style=\"color: #000080;\"><strong>\u5206\u5b50\u8a3a\u65ad\u3088\u308a\u3082\uff0c\u753b\u50cf\u6240\u898b\u306b\u3088\u308b\u816b\u760d\u5897\u5927\u901f\u5ea6\u306e\u628a\u63e1 radiological growth rate \u306e\u65b9\u304c\u751f\u5b58\u671f\u9593\u3092\u6b63\u78ba\u306b\u4e88\u60f3\u3067\u304d\u308b<\/strong><\/span>\u306e\u3067\uff0c\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u306e\u4e88\u60f3\u306b\u306f\u753b\u50cf\u5909\u5316\u3092\u52a0\u3048\u3066\u8aac\u660e\u3092\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u305d\u306e\u4e0a\u3067\u6cbb\u7642\u9078\u629e\u80a2\u3092\u63d0\u793a\u3057\u307e\u3059<\/li>\n\n\n\n<li>\u3066\u3093\u304b\u3093\u767a\u4f5c\uff0c\u8a8d\u77e5\u6a5f\u80fd\uff0c\u60a3\u8005\u3055\u3093\u306e\u5e0c\u671b\uff0c\u7d4c\u6e08\u72b6\u614b\uff0c\u5bb6\u65cf\u69cb\u6210\u306a\u3069\u3092\u3088\u304f\u3088\u304f\u8003\u3048\u3066\u6cbb\u7642\u65b9\u91dd\u3092\u6c7a\u3081\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span style=\"color: #ff0000;\"><strong>\u5206\u5b50\u8a3a\u65ad\u3067\u306e\u6cbb\u7642\u9078\u629e<\/strong><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span style=\"color: #333333;\"><a href=\"\/sawamura\/glioma\/astrocytictumor\/\"><span style=\"color: #000080;\"><strong>\u661f\u7d30<\/strong><strong>\u80de\u7cfb\u816b\u760d<\/strong><\/span><\/a>\u3068<a href=\"\/sawamura\/glioma\/olig\/\"><strong><span style=\"color: #000080;\">\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb<\/span><span style=\"color: #000080;\">\u816b\u760d<\/span><\/strong><\/a>\u3067\u306f\uff0c\u65e7\u6765\u306e\u7d44\u7e54\u8a3a\u65ad\u304c\u540c\u3058\u3067\u3082\u304b\u306a\u308a\u9055\u3063\u305f\u4e88\u5f8c\u306b\u306a\u308a\u307e\u3059<\/span><\/li>\n\n\n\n<li>\u6cbb\u308b\u304b\u6cbb\u3089\u306a\u3044\u304b\uff0c\u540c\u3058\u8a3a\u65ad\u540d\u3067\u3070\u3089\u3064\u304d\u304c\u5927\u304d\u304b\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059<\/li>\n\n\n\n<li>\u6700\u8fd1\u306f\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad molecular diagnosis \u304c\u305d\u308c\u3092\u88dc\u3044\u307e\u3059<\/li>\n\n\n\n<li>2021\u5e74\u6642\u70b9\u3067\u91cd\u8981\u306a\u3082\u306e\u306b\u306f\u6b21\u306e\uff13\u3064\u306e\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>\u3082\u3063\u3068\u3082<span style=\"color: #000080;\"><strong>\u91cd\u8981\u306a\u30de\u30fc\u30ab\u30fc\u306fIDH\u3068\u3044\u3046\u907a\u4f1d\u5b50<\/strong><\/span>\u3067\u3059<\/li>\n\n\n\n<li>\u3053\u308c\u3089\u304c\u691c\u51fa\u3055\u308c\u308b\u3068\u6cbb\u7642\u304c\u52b9\u304d\u3084\u3059\u304f\u6bd4\u8f03\u7684\u306b\u4e88\u5f8c\u304c\u826f\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n\n\n\n<li>\u4f8b\u3048\u3070\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\uff08\u30b0\u30ec\u30fc\u30c9\uff13\uff09\u3067<span style=\"color: #000080;\"><strong>1p\/19q\u306e\u5171\u6b20\u5931<\/strong><\/span>\u304c\u3042\u308a\uff0c<strong><span style=\"color: #000080;\">MGMT\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3<\/span><\/strong>\u304c\u3042\u308a\uff0cIDH1\/2\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308c\u3070\uff0c\u6cbb\u308b\u671f\u5f85\u304c\u3082\u3066\u307e\u3059<\/li>\n\n\n\n<li>\u3053\u308c\u3089\u306e\u30de\u30fc\u30ab\u30fc\u3092\u7528\u3044\u3066\u6cbb\u7642\u65b9\u6cd5\u3092\u9078\u629e\u3057\u3088\u3046\u3068\u3044\u3046\u610f\u898b\u306f\uff0c2005\u5e74\u3053\u308d\u304b\u3089\u3042\u308b\u306e\u3067\u3059\u304c\u4e00\u822c\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f<\/li>\n\n\n\n<li>\u691c\u67fb\u304c\u9762\u5012\u3067\u3057\u3070\u3057\u3070\u4fe1\u983c\u6027\u306b\u6b20\u3051\u308b\u3068\u3044\u3046\u3053\u3068\u3082\u539f\u56e0\u3067\u3059<\/li>\n\n\n\n<li>\u3082\u3046\u4e00\u3064\u306e\u5927\u304d\u306a\u7406\u7531\u306b\uff0c2022\u5e74\u6642\u70b9\u3067\u3082\u6709\u52b9\u6027\u304c\u3042\u308b<span style=\"color: #000080;\"><strong>\u5316\u5b66\u7642\u6cd5\u5264\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3057\u304b\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u4e8b\u5b9f\u304c\u3042\u308a\u307e\u3059<\/li>\n\n\n\n<li>MGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u306a\u3044\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u52b9\u6027\u306f\u4f4e\u3044\u306e\u3067\u3059\u304c\uff0c\u3060\u304b\u3089\u3068\u3044\u3063\u3066\u4ed6\u306b\u4f55\u304b\u9078\u629e\u80a2\u304c\u3042\u308b\u304b\u3068\u3044\u3046\u3068\uff0c\u7121\u3044\u306e\u3067\uff0c\u7d50\u679c\u7684\u306b\u4f7f\u7528\u3059\u308b\u5236\u304c\u3093\u5264\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306a\u3089\uff0c\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u304c\u306a\u3093\u3067\u3042\u308c\u540c\u3058\u6cbb\u7642\u9078\u629e\u3068\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">mutations of isocitrate dehydrogenase (IDH) 1 and 2<\/h2>\n\n\n\n<p>IDH1 codon 132, IDH2 codon 172 missense mutation\u3092\u307f\u307e\u3059\u3002\u65b9\u6cd5\u3068\u3057\u3066\uff0cIDH1 R132H \u6297\u4f53\u306b\u3088\u308b\u514d\u75ab\u67d3\u8272\u304bIDH1\/2 mutation hotspot sequencing\u3092\u3057\u307e\u3059\u3002<span style=\"color: #000080;\"><strong>IDH\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u7d44\u7e54\u578b\u306b\u3088\u3089\u305a\u4e88\u5f8c\u304c\u826f\u3044<\/strong><\/span>\uff08\u6cbb\u308a\u3084\u3059\u3044\uff09\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002MRS\u3068\u3044\u3046\u691c\u67fb\u3067\u3053\u306e\u5909\u7570\u306e\u6709\u7121\u304c\u4e88\u6e2c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002IDH\u5909\u7570\u304c\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u624b\u8853\u3067\u6458\u51fa\u3067\u304d\u308b\u78ba\u7387\u304c\u4e0a\u304c\u308a\u307e\u3059\u3002<span style=\"color: #000080;\"><strong>2023\u5e746\u6708\u306b\uff0c\u5909\u7570\u578bIDH\u963b\u5bb3\u5264\uff0c<span style=\"color: #ff0000;\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib\uff08\u98f2\u307f\u85ac\uff09<\/span>\u306e\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\uff0c\u30b0\u30ec\u30fc\u30c9\uff12\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577<\/strong><\/span>\u304c\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\uff0c\u3082\u3046\u3059\u3050\u65e5\u672c\u3067\u3082\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u306e\u3067\u3057\u3087\u3046<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1p\/19q chromosomal codel<span style=\"color: #000080;\">etio<\/span>n<\/h2>\n\n\n\n<p><span style=\"color: #000080;\"><span style=\"color: #000080;\"><a title=\"\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\" href=\"\/sawamura\/braintumors\/olig\/\"><span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d<\/strong><\/span><\/a>\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3059<\/span><\/span>\uff0c\u7b2c1\u67d3\u8272\u4f53\u5358\u8155\u3068\u7b2c19\u67d3\u8272\u4f53\u9577\u8155\u306e\u5171\u6b20\u5931\u304c\u3042\u308b\u3082\u306e\u306b\u306f\u5316\u5b66\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u826f\u304f\u52b9\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">O(6)-MGMT promoter methylation<\/h2>\n\n\n\n<p>MGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308b\u3068\u30c6\u30e2\u30c0\u30fc\u30eb\u306a\u3069\u306e\u5316\u5b66\u7642\u6cd5\u5264\u304c\u52b9\u304f\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u306a\u3044\u4f8b\u3067\u306f\u9006\u306b\u85ac\u5264\u304c\u52b9\u304d\u307e\u305b\u3093\u3002\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u6709\u7121\u306e\u5224\u5b9a\u306f\u96e3\u3057\u304f\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067\u306e\u4fe1\u983c\u6027\u306f\u4f4e\u3044\u3067\u3059\u304c\uff0c\u65e5\u672c\u3067\u306f\u307b\u3068\u3093\u3069\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u306b\u983c\u3063\u3066\u3044\u307e\u3059\u3002IDH\u5909\u7570\u306e\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u306e80%\u304f\u3089\u3044\u306b\uff0cMGMT\u306e\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u9f62\u8005\u3067\u306f\u7279\u306b\u91cd\u8981\u306a\u6307\u6a19\u3067\u3042\u308a\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3059\u308b\u304b\u3069\u3046\u304b\u306e\u5224\u65ad\u306e\u57fa\u6e96\u3068\u3057\u307e\u3059\u3002\u305f\u3060\u30572022\u5e74\u6642\u70b9\u3067\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306fMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u691c\u67fb\u3059\u308b\u81e8\u5e8a\u7684\u610f\u7fa9\u306f\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">loss of nuclear ATRX expression<\/h2>\n\n\n\n<p>\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067\u5224\u5b9a\u3067\u304d\u307e\u3059\u3002\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306b\u7279\u5fb4\u7684\u3067\u3059\u304b\u3089\uff0cIDH\u5909\u7570\u304c\u3042\u3063\u3066\u3053\u306e\u6b20\u640d\u304c\u8a8d\u3081\u3089\u308c\u308c\u30701p\/19q\u306e\u67d3\u8272\u4f53\u691c\u67fb\u3092\u3057\u306a\u304f\u3066\u3082<span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/astrocytictumor\/\">\u661f\u7d30\u80de\u7cfb\u816b\u760d astrocytic lineage tumor <\/a>\u3068\u5224\u5b9a\u3067\u304d\u307e\u3059<\/strong><\/span>\u3002\u9006\u306b\uff0c\u3084\u3084\u6cbb\u308a\u306b\u304f\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6307\u6a19\u3068\u3082\u8a00\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CDKN2A\/CDKN2B&nbsp;homozygous deletion<\/h2>\n\n\n\n<p>\u7279\u306b\u30b0\u30ec\u30fc\u30c93\u306e\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\uff09\u306e\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50\u306e\u4e00\u3064\u3068\u3055\u308c\u307e\u3057\u305f\u30022021\u5e74\u6642\u70b9\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>CDKN2A\u5171\u6b20\u5931\u304c\u3042\u308b\u3068IDH\u5909\u7570\u304c\u3042\u3063\u3066\u3082\u4e88\u5f8c\u4e0d\u826f<\/strong><strong>\u3067\u30b0\u30ec\u30fc\u30c9\uff14<\/strong><\/span>\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Histone K27M mutation<\/h2>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u306e\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c94\u3067\u4e88\u5f8c\u4e0d\u826f\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Histone H3.3 G34 mutation<\/h2>\n\n\n\n<p><span style=\"color: #000080;\"><strong>\u5927\u8133\u534a\u7403\u3073\u307e\u3093\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u3067\uff0cWHO \u30b0\u30ec\u30fc\u30c94\u306b\u76f8\u5f53\u3057\u307e\u3059<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><i>EGFR&nbsp;<\/i>amplification<\/h2>\n\n\n\n<p>\u81a0\u82bd\u816b\u306e\u534a\u6570\u304f\u3089\u3044\u3067\u8a8d\u3081\u3089\u308c\u307e\u3059<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><i>TERT<\/i> promotor mutation<\/h2>\n\n\n\n<p>\u307b\u3068\u3093\u3069\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\uff0c7\u5272\u304f\u3089\u3044\u306e\u81a0\u82bd\u816b\u3067\u5909\u7570\u304c\u3042\u308a\u307e\u3059<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><i>BRAF<\/i><sup>V600E&nbsp;<\/sup>mutation<\/h2>\n\n\n\n<p>\u6210\u4eba\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u307e\u308c\u3067\uff0c\u5c0f\u5150\u306ePXA\u3084ganglioglioma\u306a\u3069\u3067\u5909\u7570\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u60a3\u8005\u3055\u3093\u306e\u5168\u8eab\u72b6\u614b\u306e\u6307\u6a19 Performance Status (PS)<\/strong><\/h4>\n\n\n\n<p>\u3053\u306e\u6307\u6a19\u5024\u304c\u9ad8\u3044\u3068\u7a4d\u6975\u7684\u306a\u6cbb\u7642\u3092\u3057\u306a\u3044\uff0c\u4f4e\u3051\u308c\u3070\u5f37\u3044\u5316\u5b66\u7642\u6cd5\u3082\u884c\u3046\u3068\u3044\u3046\u5224\u65ad\u57fa\u6e96\u306b\u306a\u308a\u307e\u3059\u3002PS 3\u4ee5\u4e0a\u3067\u306f\u6cbb\u7642\u3057\u306a\u3044\u3068\u304b\uff0cKPS 70\u4ee5\u4e0a\u3067\u3053\u306e\u6cbb\u7642\u3092\u884c\u3046\u3068\u304b\u8a18\u8ff0\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8133\u816b\u760d\u306e\u9818\u57df\u3067\u306f\uff0cECOG\u3068\u3044\u3046\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u6307\u6a19\u304c\u3088\u304f\u7528\u3044\u3089\u308c\u307e\u3059\uff08<a href=\"http:\/\/www.ecog.org\/general\/perf_stat.html\">\u539f\u5178\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a>\uff09<span style=\"text-decoration: underline;\"><span style=\"color: #000080; text-decoration: underline;\"><strong>Zubrod scale<\/strong><\/span><\/span><span style=\"color: #333333;\">\u3068\u3044\u3044\u307e\u3059\u3002<\/span><br><em><span style=\"text-decoration: underline;\"><span style=\"color: #ff0000; text-decoration: underline;\"><strong>0<\/strong><\/span><\/span><\/em>&nbsp; \u554f\u984c\u306a\u304f\u793e\u4f1a\u6d3b\u52d5\u3067\u304d\u308b\u3002 \u767a\u75c5\u524d\u3068\u540c\u3058\u751f\u6d3b\u304c\u5236\u9650\u306a\u304f\u884c\u3048\u308b\u3002<br><span style=\"text-decoration: underline;\"><em><strong><span style=\"color: #ff0000; text-decoration: underline;\">1<\/span><\/strong><\/em><\/span>&nbsp; \u8efd\u5ea6\u306e\u75c7\u72b6\u304c\u3042\u308a\uff0c\u8089\u4f53\u7684\u306b\u6fc0\u3057\u3044\u6d3b\u52d5\u306f\u5236\u9650\u3055\u308c\u308b\u304c\u3001\u6b69\u884c\u3001\u8efd\u4f5c\u696d\uff0c\u5ea7\u3063\u3066\u306e\u4f5c\u696d\u306f \u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4f8b\u3048\u3070\u8efd\u3044\u5bb6\u4e8b\u3001\u4e8b\u52d9\u3002<br><em><strong><span style=\"color: #ff0000;\">2<\/span><\/strong><\/em> &nbsp;\u6b69\u884c\u304c\u3067\u304d\uff0c\u81ea\u5206\u306e\u8eab\u306e\u56de\u308a\u306e\u3053\u3068\u3067\u304d\u308b\u304c\uff0c\u8efd\u4f5c\u696d\u304c\u3067\u304d\u306a\u3044\u3002\u65e5\u4e2d\u306e50%\u4ee5\u4e0a\u306f\u8d77\u5e8a\u3057\u3066\u904e\u3054\u3059\u3002<br><span style=\"text-decoration: underline;\"><em><strong><span style=\"color: #ff0000; text-decoration: underline;\">3<\/span><\/strong><\/em><\/span>&nbsp; \u81ea\u5206\u306e\u8eab\u306e\u56de\u308a\u306e\u3042\u308b\u7a0b\u5ea6\u306e\u3053\u3068\u3057\u304b\u3067\u304d\u305a\uff0c\u3057\u3070\u3057\u3070\u4ecb\u52a9\u304c\u5fc5\u8981\u3002\u65e5\u4e2d\u306e50%\u4ee5\u4e0a\u3092\u30d9\u30c3\u30c9\u304b\u6905\u5b50\u3067\u904e\u3054\u3059\u3002<br><span style=\"text-decoration: underline;\"><strong><em><span style=\"color: #ff0000; text-decoration: underline;\">4<\/span><\/em><\/strong><\/span>&nbsp; \u307b\u3069\u3093\u3069\u52d5\u304f\u3053\u3068\u304c\u3067\u304d\u305a\uff0c \u81ea\u5206\u306e\u8eab\u306e\u56de\u308a\u306e\u3053\u3068\u306f\u5168\u304f\u3067\u304d\u306a\u3044\u3002\u7d42\u65e5\u30d9\u30c3\u30c8\u304b\u6905\u5b50\u3067\u904e\u3054\u3059\u3002<\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"color: #000080; text-decoration: underline;\"><strong>KPS&nbsp; (\u30ab\u30eb\u30ce\u30d5\u30b9\u30ad\u30fc\u30fb\u30d1\u30fc\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u30fb\u30b9\u30c6\u30a4\u30bf\u30b9\uff09<\/strong><\/span><br><\/span>\u30ab\u30eb\u30ce\u30d5\u30b9\u30ad\u30fc\u306e\u4e00\u822c\u5168\u8eab\u72b6\u614b\u30b9\u30b3\u30a2\u3068\u306f\uff0c<span style=\"color: #ff0000;\"><span style=\"color: #333333;\">PS\u309210\u6bb5\u968e\u306b\u5206\u3051\u308b\u30b9\u30b1\u30fc\u30eb\u3067\u3059<\/span><\/span><br><strong><span style=\"color: #ff0000;\">100&nbsp;<\/span><\/strong>\u6b63\u5e38&nbsp;<strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><span style=\"color: #333333;\"><strong><span style=\"color: #ff0000;\">90 &nbsp;<\/span><\/strong>\u8efd\u3044\u81e8\u5e8a\u75c7\u72b6\u306f\u3042\u308b\u304c\u6b63\u5e38\u6d3b\u52d5\u53ef\u80fd<\/span><strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><span style=\"color: #ff0000;\"><span style=\"color: #333333;\"><strong><span style=\"color: #ff0000;\">80<\/span> &nbsp;<\/strong>\u304b\u306a\u308a\u81e8\u5e8a\u75c7\u72b6\u304c\u3042\u308b\u304c\uff0c\u52aa\u529b\u3057\u3066\u6b63\u5e38\u306e\u6d3b\u52d5\u53ef\u80fd<\/span><\/span><strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><strong><span style=\"color: #ff0000;\">70 &nbsp;<\/span><\/strong>\u52b4\u50cd\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044&nbsp;<strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><span style=\"color: #333333;\"><strong><span style=\"color: #ff0000;\">60 &nbsp;<\/span><\/strong>\u81ea\u5206\u306b\u5fc5\u8981\u306a\u3053\u3068\u306f\u3067\u304d\u308b\u304c\uff0c\u3068\u304d\u3069\u304d\u4ecb\u52a9\u304c\u5fc5\u8981<\/span><strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><span style=\"color: #ff0000;\"><span style=\"color: #333333;\"><strong><span style=\"color: #ff0000;\">50<\/span> &nbsp;<\/strong>\u75c5\u72b6\u3092\u8003\u616e\u3057\u305f\u770b\u8b77\u304a\u3088\u3073\u5b9a\u671f\u7684\u306a\u533b\u7642\u884c\u70ba\u304c\u5fc5\u8981<\/span><\/span><strong><span style=\"color: #ff0000;\"><br><\/span><\/strong><span style=\"color: #ff0000;\"><strong>40 &nbsp;<\/strong><\/span>\u52d5\u3051\u306a\u304f\u3066\u4ecb\u8b77\u3084\u533b\u7642\u304c\u5fc5\u8981\u306a\u72b6\u614b&nbsp;<span style=\"color: #ff0000;\"><span style=\"color: #333333;\"><br><strong><span style=\"color: #ff0000;\">0<\/span> &nbsp;&nbsp;<\/strong>\u6b7b\u4ea1&nbsp;<\/span><\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u30b0\u30ea\u30aa\u30fc\u30de\u6cbb\u7642\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb<\/strong><\/h4>\n\n\n\n<p>\u3044\u308d\u3093\u306a\u60c5\u5831\u304c\u3069\u3053\u307e\u3067\u4fe1\u3058\u3089\u308c\u308b\u304b\u3092\u30ec\u30d9\u30eb\u306b\u8868\u3057\u305f\u3082\u306e\u3067\u3059\u30021\u301c4\u3068\u304b1\u301c6\u3068\u304b\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002\u5c02\u9580\u5bb6\u500b\u4eba\u306e\u610f\u898b\u306e\u610f\u898b\u3067\u306f\u306a\u304f\uff0c\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u5ba2\u89b3\u7684\u306a\u6cbb\u7642\u3092\u9078\u3076\u305f\u3081\u306e\u6307\u91dd\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u4f8b\u3048\u3070\uff0c\u514d\u75ab\u6cbb\u7642\uff0c\u30a6\u30a3\u30eb\u30b9\u6cbb\u7642\uff0c\u30ef\u30af\u30c1\u30f3\u3067\u60aa\u6027\u8133\u816b\u760d\u304c\u6cbb\u308b\u3068\u3044\u3046\u306e\u306f\uff0c\u30ec\u30d9\u30eb5\u3067\uff0c\u6700\u4f4e\u30e9\u30f3\u30af\u306e\u60c5\u5831<\/strong><\/span>\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/immunotherap\/\">\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u514d\u75ab\u6cbb\u7642\uff08\u8a73\u3057\u304f\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/span><\/h3>\n\n\n\n<p>&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/owlglioma1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"591\" height=\"491\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/owlglioma1.jpg\" alt=\"\" class=\"wp-image-1941\" title=\"owlglioma\"\/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center\"><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u3053\u3053\u304b\u3089\u4e0b\u306f\u5c02\u9580\u5bb6\u3080\u3051<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u6cbb\u7642\u52b9\u679c\u306e\u5224\u5b9a\u3092\u3069\u3046\u3059\u308b\u304b RANO criteria<\/strong><\/h4>\n\n\n\n<p><span style=\"color: #000080;\"><strong>MacDonald criteria<\/strong><\/span>\u3068\u3044\u3046\u5224\u5b9a\u6cd5\u304c\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002MRI\u3067\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u306e\u816b\u760d\u3092\u4ea4\u5dee\u3059\u308b2\u3064\u306e\u9577\u5f84\u3067\u6e2c\u5b9a\u3059\u308b\u65b9\u6cd5\u3067\u3059\u300225%\u4ee5\u4e0a\u306e\u5897\u5927\u3067\u816b\u760d\u9032\u884c PD\u3068\u3057\u307e\u3059\u3002\u305d\u308c\u306b\u81e8\u5e8a\u75c7\u72b6\u3068\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u4f7f\u7528\u91cf\u3092\u52a0\u5473\u3057\u3066\u8a55\u4fa1\u3057\u307e\u3059<\/p>\n\n\n\n<p>\u3057\u304b\u3057\uff0c\u3053\u306e\u8a55\u4fa1\u65b9\u6cd5\u304c\u901a\u7528\u3057\u306a\u304f\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7406\u7531\u306f\uff12\u3064\u3042\u308a\u307e\u3059\u3002\u7b2c1\u306b\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u884c\u306a\u3046\u3068\uff0c3\u30f6\u6708\u4ee5\u5185\u304f\u3089\u3044\u306b\u4e00\u898b\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u305f\u3088\u3046\u306b\u898b\u3048\u308b<span style=\"color: #000080;\"><strong><a title=\"pseudoprogression\" href=\"\/sawamura\/braintumors\/pseudoprogression\/\">\u30b9\u30fc\u30c9\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30e7\u30f3<\/a><\/strong><\/span>\u3068\u3044\u3046\u73fe\u8c61\u304c\uff12\u2212\uff13\u5272\u3067\u751f\u3058\u308b\u3053\u3068\u3067\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u75c5\u5909\u304c\u62e1\u5927\u3057\u307e\u3059\u3002 \u3057\u304b\u3057\uff0c\u3053\u306e\u75c5\u5909\u62e1\u5927\u306f\u81ea\u7136\u306b\u6539\u5584\u3057\u307e\u3059\u3002\u7b2c2\u306b\uff0c\u30a2\u30d0\u30b9\u30c1\u30f3 (antiangiogenetic agent) \u3092\u4f7f\u7528\u3059\u308b\u3068\uff0c\u6295\u4e0e\u6570\u65e5\u4ee5\u5185\u306b\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u75c5\u5909\u304c\u7e2e\u5c0f\u3057\u3066\uff0c\u4e00\u898b\u6cbb\u7642\u304c\u3068\u3066\u3082\u6709\u52b9\u306a\u3088\u3046\u306b\u307f\u3048\u308b\u3053\u3068\u3067\u3059\u3002\u3067\u3082\u816b\u760d\u304c\u60aa\u5316\u3057\u3066\u3044\u308b\u3068\uff0cT2\/FLAIR\u3067\u9ad8\u4fe1\u53f7\u306b\u306a\u308b\u75c5\u5909\u3060\u3051\u306f\u62e1\u5927\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u8840\u6db2\u8133\u95a2\u9580\u306e\u900f\u904e\u6027\u304c\u4e0b\u304c\u3063\u3066\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u304c\u816b\u760d\u7d44\u7e54\u5185\u306b\u6f0f\u51fa\u3067\u304d\u306a\u304f\u306a\u308b\u3068\u3044\u3046\u73fe\u8c61\u3092\u307f\u3066\u3044\u308b\u3060\u3051\u306a\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>MacDonard criteria\u3092\u6539\u5909\u3057\u305f<a href=\"http:\/\/www.iconplc.com\/jp\/our-services\/imaging\/central-imaging-core-lab-\/regulatory-expertise\/IMI-RANO-Critieria-Booklet-Nov-2011.pdf\"><strong><span style=\"color: #000080;\">RANO (Response Assessment in Neuro-Oncology) criteria<\/span><\/strong><\/a>\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u6cbb\u7642\u7d42\u4e8612\u9031\u9593\u4ee5\u5185\u3067\u306f\uff0c80% isodose line\u3092\u8d8a\u3048\u305f\u65b0\u5897\u5f37\u75c5\u5909\u306e\u51fa\u73fe\u304b\u518d\u624b\u8853\u306b\u3088\u3063\u3066\u75c5\u7406\u8a3a\u65ad\u3055\u308c\u306a\u3051\u308c\u3070\u816b\u760d\u9032\u884c PD\u3068\u306f\u3044\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u5f8c\u306b\u306f\uff0c25%\u4ee5\u4e0a\u306e\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u75c5\u5909\u306e\u5897\u5927\uff0c\u65b0\u75c5\u5909\u306e\u51fa\u73fe\uff0c\u81e8\u5e8a\u75c7\u72b6\u306e\u660e\u3089\u304b\u306a\u60aa\u5316\uff0cantiangiogenic agent\u306e\u4f7f\u7528\u306b\u3082\u95a2\u308f\u3089\u305aT2\/FLAIR\u75c5\u5de3\u304c\u62e1\u5927\u3059\u308b\u3053\u3068\u306a\u3069\u3067\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">RANO criteria<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"550\" height=\"332\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ranocriteria-550x332.png\" alt=\"ranocriteria\" class=\"wp-image-9608\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ranocriteria-550x332.png 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ranocriteria-300x181.png 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ranocriteria-768x463.png 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/ranocriteria.png 902w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>patient-reported outcome (PRO)<\/strong><\/h4>\n\n\n\n<p>\u6700\u8fd1\u306e\u6cbb\u7642\u6cd5\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u4e00\u3064\u306e\u5927\u304d\u306a\u57fa\u6e96\u3067\u3059\u3002\u533b\u5e2b\u306f5\u5e74\u751f\u5b58\u7387\u304c\u6539\u5584\u3059\u308c\u3070\uff0c\u305d\u306e\u6cbb\u7642\u304c\u826f\u3044\u6cbb\u7642\u3060\u3068\u8a00\u3044\u307e\u3059\u3002\u3067\u3082\uff0c\u60a3\u8005\u3055\u3093\u306f\u6cbb\u7642\u3092\u53d7\u3051\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5358\u306b\u547d\u304c\u6570\u30f6\u6708\u4f38\u3073\u3066\uff0c\u751f\u6d3b\u304c\u3059\u3054\u304f\u82e6\u3057\u304f\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<span style=\"color: #000080;\"><strong>\u60a3\u8005\u3055\u3093\u5074\u304b\u3089\u306e\u8a55\u4fa1 PRO<\/strong><\/span>\u3067\u305d\u306e\u6cbb\u7642\u6cd5\u304c\u6709\u76ca\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u3068\u3044\u3046\u57fa\u6e96\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u5206\u5b50\u8a3a\u65ad\u3088\u308a\u753b\u50cf\u8a3a\u65ad\u306e\u65b9\u304c\u4e88\u5f8c\u304c\u826f\u304f\u308f\u304b\u308b<\/h4>\n\n\n\n<p><span class=\"refAuthors\">Goz\u00e9, C, Blonski, M, Le Maistre, G et al. <\/span><span class=\"refTitle\">Imaging growth and isocitrate dehydrogenase 1 mutation are independent predictors for diffuse low-grade gliomas. <\/span><span class=\"refSeriesTitle\">Neuro Oncol 16,<\/span>&nbsp;<span class=\"refSeriesDate\">2014<br>131\u4eba\u306e\u7d44\u7e54\u5b66\u7684\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u3093\u306e\u4e88\u5f8c\u89e3\u6790\u3067\u3059\u3002107\u4eba\u306bIDH1\u306e\u5909\u7570\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u753b\u50cf\u8a3a\u65ad\u3067\u306f5.4mm\/\u5e74\u306e\u5e73\u5747\u5897\u5927\u901f\u5ea6\u3067\u3057\u305f\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593 PFS\u306f\uff0c<br>IDH1\u5909\u7570\u304c\u3042\u308b\u3068\u4e88\u5f8c\u304c\u826f\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5168\u4f53\u3067\u898b\u308b\u3068\uff0c\u60aa\u6027\u9032\u884c\u306e\u306a\u3044PFS\u306f\u753b\u50cf\u4e0a\u3067\u3086\u3063\u304f\u308a\u3057\u305f\u5897\u5927\u901f\u5ea6\u3092\u793a\u3057\u305f\u3082\u306e\u3067149\u30f6\u6708\uff0cIDH1\u5909\u7570\u306e\u3042\u3063\u305f\u3082\u306e\u3067100\u30f6\u6708\u3067\u3059\u3002IDH1\u306e\u5909\u7570\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\uff0c\u753b\u50cf\u4e0a\u3067\u5897\u5927\u901f\u5ea6\u306e\u9045\u3044\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u4e88\u5f8c\u306f\u826f\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<br>\u300c\u89e3\u8aac\u300dIDH1\u5909\u7570\u304c\u306a\u3044\u3068\u81a0\u82bd\u816b\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\uff0c\u304b\u306a\u308a\u7a4d\u6975\u7684\u306a\u6cbb\u7642\u3092\u884c\u3046\u3068\u3044\u3046\u98a8\u6f6e\u306b\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u3057\u3070\u3089\u304f\u7d4c\u904e\u3092\u898b\u3066\u3044\u3066MRI\u3067\u304b\u306a\u308a\u3086\u3063\u304f\u308a\u3057\u304b\u5897\u5927\u3057\u306a\u3044\u3082\u306e\u306e\u4e88\u5f8c\u306f\uff0c\u5206\u5b50\u8a3a\u65ad\u3067\u4e88\u60f3\u3059\u308b\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u826f\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">MRI\u753b\u50cf\u8a3a\u65ad\u3067\u898b\u3048\u308b\u4e88\u5f8c<\/h4>\n\n\n\n<p>Pallud, J, Blonski, M, Mandonnet, E et al.&nbsp;Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas.&nbsp;Neuro Oncol 15, 2013<span class=\"refSeriesDate\"><br>407\u4eba\u306e\u6210\u4eba\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u3093\u306e\u4e88\u5f8c\u89e3\u6790\u3067\u3059\u3002\u753b\u50cf\u8a3a\u65ad\u3067\u306f5.8mm\/\u5e74\u306e\u5e73\u5747\u5897\u5927\u901f\u5ea6\u3067\u3057\u305f\u30027\u5e74\u4f59\u308a\u306e\u8ffd\u8de1\u671f\u9593\u3067209\u4eba\u306b\u60aa\u6027\u8ee2\u5316 malignant transformation\u304c\u751f\u3058\u307e\u3057\u305f\u3002\u6cbb\u7642\u524d\u306eMRI\u4e0a\u3067\u306e\u5897\u5927\u901f\u5ea6\u306e\u3086\u3063\u304f\u308a\u3057\u305f\u3082\u306e\u306f\uff0c\u751f\u5b58\u671f\u9593\u304c\u9577\u3044\u3068\u3044\u3046\u306f\u3063\u304d\u308a\u3057\u305f\u7d50\u679c\u304c\u51fa\u305f\u305d\u3046\u3067\u3059\u3002\u5206\u5b50\u8a3a\u65ad\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u6cbb\u7642\u524d\u306e\u816b\u760d\u5897\u5927\u901f\u5ea6\u3092\u898b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u5b58\u671f\u9593\u306e\u4e88\u6e2c\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u518d\u8a8d\u8b58\u3059\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3002<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u60aa\u6027\u5ea6\u306e\u3082\u3046\u4e00\u3064\u306e\u6307\u6a19\uff1a\u30df\u30d6 MIB<\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"225\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/aamib-300x225.jpg\" alt=\"\" class=\"wp-image-11981\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/aamib-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/aamib-768x576.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/aamib-550x413.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/aamib.jpg 1280w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n<p><br>\u7d44\u7e54\u8a3a\u65ad\u3059\u308b\u3068Ki-67\u3068\u3044\u3046\u6297\u4f53\u3067\u300cMIB-1\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u300d\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306eMIB-1 (Ki-67) \u67d3\u8272\u7387\u3092labling index\u3068\u3044\u3044\u307e\u3059\u3002\u9ed2\u3063\u307d\u304f\u67d3\u307e\u3063\u3066\u3044\u308b\u306e\u304c\u967d\u6027\u7d30\u80de\uff0c\u8584\u3044\u9752\u304c\u9670\u6027\u7d30\u80de\u3067\u3059\u3002\u3053\u306e\u4f8b\u3067\u306f20%\u304f\u3089\u3044\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u30b0\u30ec\u30fc\u30c9\u8a3a\u65ad\uff0c\u5206\u5b50\u8a3a\u65ad\u3068\u3068\u3082\u306b\uff0c\u60a3\u8005\u3055\u3093\u306e\u4e88\u5f8c\u3092\u6c7a\u3081\u308b\u5927\u304d\u306a\u56e0\u5b50\u3067\u3059\u3002\u816b\u760d\u306e\u5897\u6b96\u901f\u5ea6\u304c\u9045\u3044\u30b0\u30ec\u30fc\u30c91\u306f1%\uff0c\u30b0\u30ec\u30fc\u30c92\u30672-5%\u304f\u3089\u3044\u3067\u3059\u3002\u81a0\u82bd\u816b\u3067\u306f20%\u3092\u8d85\u3048\u308b\u5024\u306b\u3082\u306a\u308a\uff0c\u305d\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u306f\uff11\u9031\u9593\u5358\u4f4d\u3067\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u8c46\u77e5\u8b58\u3000\u30b0\u30ea\u30a2<\/h5>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"290\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/astroglia-300x290.jpg\" alt=\"\" class=\"wp-image-11847\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/astroglia-300x290.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/astroglia-550x532.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/astroglia.jpg 709w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n\n\n<p><br>\u30b0\u30ea\u30a2 glia, glial\u306f\uff0c\u30ae\u30ea\u30b7\u30e3\u8a9e\u306e&#8221;glue&#8221;\u306b\u7531\u6765\u3057\u307e\u3059\u3002\u7c98\u3063\u3068\u3057\u305f\u3082\u306e\u3068\u3044\u3046\u610f\u5473\u3067\u3059\u3002\u82f1\u8a9e\u306e glue \u306f\u7cca\uff08\u30ce\u30ea\uff09\u3067\u3059\u3002\u5b9f\u969b\u306b\u624b\u8853\u3067\u6458\u51fa\u3057\u3088\u3046\u3068\u3059\u308b\u3068\u3061\u3087\u3063\u3068\u306d\u3070\u3063\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u308f\u305a\u304b\u306a\u7c98\u308a\uff0c\u786c\u3044\u7c98\u6db2\u306e\u3088\u3046\u306a\u611f\u89e6\u3092\u624b\u639b\u308a\u306b\u816b\u760d\u6458\u51fa\u3092\u3057\u307e\u3059\u3002\u65e5\u672c\u8a9e\u3067\u306e\u81a0\u7d30\u80de\uff0c\u81a0\u816b\u306e\u300c\u81a0 \u306b\u304b\u308f\u300d\u3068\u3044\u3046\u8a33\u306f\u3042\u307e\u308a\u3044\u305f\u3060\u3051\u307e\u305b\u3093\u3002\u81a0\u307b\u3069\u306b\u306f\u7c98\u6027\u306e\u5f37\u3044\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br>\u5de6\u306e\u5199\u771f\u306f\u9577\u3044\u7a81\u8d77\u3092\u56db\u65b9\u306b\u4f38\u3070\u3059\u30a2\u30b9\u30c8\u30ed\u30b0\u30ea\u30a2\u3067\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u8c46\u77e5\u8b58\u3000\u907a\u4f1d\u3059\u308b\u30b0\u30ea\u30aa\u30fc\u30de<\/h5>\n\n\n\n<p>\u907a\u4f1d\u6027\u306b\u767a\u751f\u3059\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u3042\u308a\u307e\u3059\u3002\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b (NF-1)\uff0c\u30bf\u30fc\u30b3\u30c3\u30c8\u75c7\u5019\u7fa4 (Turcot syndrome)\uff0c\u30ea\u30fb\u30d5\u30e9\u30a6\u30e1\u30ea\u75c7\u5019\u7fa4 (Li Fraumeni syndrome)\u3067\u3059\u3002<br>NF-1\u4ee5\u5916\u306f\u6975\u3081\u3066\u7a00\u306a\u3082\u306e\u3067\u3059\u3002\u3067\u3059\u304b\u3089\uff0cNF-1\u3092\u6301\u3063\u3066\u3044\u308b\u5bb6\u7cfb\u3067\u306a\u3051\u308c\u3070\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u907a\u4f1d\u3057\u306a\u3044\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">\u6587\u732e\u60c5\u5831<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\"><i>BRAF<\/i> V600 mutation\u306e\u3042\u308b\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u3068\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u304c\u6709\u52b9<\/h4>\n\n\n\n<p class=\"heading-title\"><span class=\"authors-list-item \">Bouffet E:&nbsp;<\/span>Dabrafenib plus Trametinib in Pediatric Glioma with <i>BRAF<\/i> V600 Mutations. N Engl J Med 2023<br>\u4e0b\u8a18\u306e\u5b66\u4f1a\u767a\u8868\u304c\u8ad6\u6587\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u5358\u72ec\u3042\u308b\u3044\u306f\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u3067\uff0c<i>BRAF<\/i> V600 mutation\u3092\u6709\u3059\u308b\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6709\u52b9\u306a\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\/\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068CBDCA\/VCR\u306e\u52b9\u679c\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002CBDCA\/VCR\u306f\u65e7\u6765\u5c0f\u5150\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6700\u3082\u4f7f\u7528\u3055\u308c\u305f\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u3067\u3059\u3002\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\/\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306744%\uff0cCBDCA\/VCR\u306711%\u306e\u594f\u529f\u7387 (CR or PR)\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u81e8\u5e8a\u7684\u306a\u5229\u70b9\u306f\u305d\u308c\u305e\u308c86%\u306846\uff05\u3067\u3057\u305f\u3002PFS\u4e2d\u592e\u5024\u306f20\u30f6\u6708\u30687.4\u30f6\u6708\u3067\u3057\u305f\u3002<br>\u300c\u4e00\u8a00\u300fPFS\u304c20\u30f6\u6708\u3068\u3044\u3046\u3053\u3068\u306f\uff0c2\u5e74\u3092\u5f85\u305f\u305a\u306b\u518d\u71c3\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><i>BRAF<\/i> V600 mutation\u306e\u3042\u308b\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u3068\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u3068\u306e\u4f75\u7528\u304c\u3042\u308b\u7a0b\u5ea6\u6709\u52b9<\/h4>\n\n\n\n<p class=\"heading-title\"><span class=\"authors-list-item \">Hargrave DR:&nbsp;<\/span>Phase II Trial of Dabrafenib Plus Trametinib in Relapsed\/Refractory <i>BRAF<\/i> V600-Mutant Pediatric High-Grade Glioma. J Clin Oncol 2023<br><i>BRAF<\/i> V600 mutation\u306f\u5c0f\u5150\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e8-10%\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u300241\u4f8b\u306e\u518d\u767a\u3042\u308b\u3044\u306f\u6cbb\u7642\u62b5\u6297\u6027\u306e\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u5bfe\u8c61\u3067\u3059\u3002\u594f\u529f\u5272\u5408\u306f56%\uff0c\u53cd\u5fdc\u671f\u9593\u4e2d\u592e\u5024\u306f22\u30f6\u6708\u3067\u3057\u305f\u3002\u534a\u5206\u304f\u3089\u3044\u306e\u4f8b\u30672\u5e74\u5f31\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"title_default\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib\u306f\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u3068\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\uff1a\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c<\/span><\/h4>\n\n\n\n<p>Mellinghoff IK:&nbsp;<span class=\"title_default\">Vorasidenib in IDH1- or IDH2-mutant low-Grade glioma. New Engl J Med 2023<br>vorasidenib\u306f\u3001\u5909\u7570\u578bIDH1\/2\u9175\u7d20\u306e\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3001\u816b\u760d\u306e2-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b0\u30eb\u30bf\u30eb\u9178\uff082-HG\uff09\u309290\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u7d4c\u53e3\u85ac\u3067\u3059\u304c\u8133\u5185\u79fb\u884c\u304c\u3088\u3044\u85ac\u5264\u3067\u3059\u3002\u8853\u5f8c\u306e\u6b8b\u5b58\u816b\u760d\u3042\u308b\u3044\u306f\u518d\u71c3 168\u4f8b\u306bvorasidenib (40 mg once daily) \u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502414.2\u30f6\u6708\u306e\u6642\u70b9\u3067\uff0c7\u5272\u306e\u60a3\u8005\u3055\u3093\u304cvorasidenib\u3042\u308b\u3044\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u7d99\u7d9a\u670d\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002PFS\u4e2d\u592e\u5024\u306f\uff0cvorasidenib\u306727.7\u30f6\u6708\uff0c\u30d7\u30e9\u30bb\u30dc\u306711.1\u30f6\u6708\u3067\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6709\u5bb3\u4e8b\u8c61\u306f22.8%\u3067\u307f\u3089\u308c\uff0cALT\u306e\u4e0a\u6607\u304c\u76ee\u7acb\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u4e2d\u6b62\u306f3.6%\u3067\u3057\u305f\u3002<\/span><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>BRAF v600\u5909\u7570\u306e\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u305d\u306e\u6bd4\u7387<\/strong><\/h4>\n\n\n\n<p>Andrews LJ: Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review. Neuro Oncol 2022<\/p>\n\n\n\n<p>1. epithelioid glioblastoma (eGBM) : 69%<br>2. <span style=\"color: #000080;\"><strong>pleomorphic xanthoastrocytoma (PXA) : 56%<\/strong><\/span><br>3. <span style=\"color: #000080;\"><strong>anaplastic pleomorphic xanthoastrocytoma (aPXA) : 38%<\/strong><\/span><br>4. <span style=\"color: #000080;\"><strong>ganglioglioma (GG) : 40%<\/strong><\/span><br>5. <strong><span style=\"color: #000080;\">anaplastic ganglioglioma (aGG) : 46%<\/span><\/strong><br>6. Prevalence in astroblastoma : 24%<br>7. desmoplastic infantile astrocytoma (DIA) : 16%<br>9. subependymal giant cell astrocytoma (SEGA) : 8%<br>10 dysembryoplastic neuroepithelial tumor (DNET): 3%<br>11 diffuse astrocytoma (DA) : 3%<br>12 pilocytic astrocytoma (PA) : 3%<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>circumscribed gliomas, glioneuronal and neuronal tumors\u306e\u6cbb\u7642\u6307\u91dd<\/strong><\/h4>\n\n\n\n<div class=\"title-wrap\">\n<p class=\"wi-article-title article-title-main accessible-content-title at-articleTitle\"><span class=\"al-author-name js-flyout-wrap\">Rud\u00e0 R:&nbsp;<\/span>EANO &#8211; EURACAN &#8211; SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors. Neuro Oncol 2022<br>\u3053\u308c\u3089\u306e\u816b\u760d\u306f\u5c0f\u5150\u304b\u3089\u82e5\u5e74\u6210\u4eba\u306b\u767a\u751f\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u816b\u760d\u3067\u306f\uff0c\u8089\u773c\u7684\u306a\u5168\u6458\u51fa\u304c\u3067\u304d\u308c\u3070\uff0c\u751f\u5b58\u671f\u9593\u3084\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\u306e\u9577\u671f\u4e88\u5f8c\u304c\u3088\u3044\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u3068\u5168\u6458\u51fa\u3067\u304d\u306a\u304b\u3063\u305f\u30b0\u30ec\u30fc\u30c92\u306b\u306f\u539f\u4f53\u7167\u5c04 conformal radiaiton therapy\u3092\u52a0\u3048\u307e\u3059\u3002\u518d\u767a\u306b\u5bfe\u3057\u3066\u306f\uff0c\u518d\u624b\u8853\u3068\u5b9a\u4f4d\u7167\u5c04\u3092\u7528\u3044\u305f\u518d\u7167\u5c04\u3092\u884c\u3044\u307e\u3059\u3002BRAF\u3068MEK\u963b\u5bb3\u5264\u304c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff0c\u591a\u578b\u9ec4\u8272\u661f\u7d30\u80de\u816b\uff0c\u795e\u7d4c\u7bc0\u81a0\u816b\u306b\u7528\u3044\u3089\u308c\uff0cmTOR\u963b\u5bb3\u5264\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306f\u4e0a\u8863\u4e0b\u5de8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306b\u6709\u52b9\u306a\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<br>\u300c\u89e3\u8aac\u300d\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3068\u306f\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u304c\uff0c\u3042\u307e\u308a\u306b\u591a\u304f\u306e\u7d44\u7e54\u578b\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u306e\u3067\uff0c\u96d1\u306a\u8ad6\u6587\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">\u5e83\u7bc4\u56f2\u6458\u51fa supratotal resection \u306f\uff0cIDH\u5909\u7570\u578b\u30b0\u30ea\u30aa\u30fc\u30de\u306eFPS\u3068OS\u3092\u304b\u306a\u308a\u5ef6\u9577\u3059\u308b<\/h4>\n\n\n\n<p class=\"heading-title\">Rossi M: Association of Supratotal Resection with Progression-Free Survival, Malignant Transformation, and Overall Survival in Lower-Grade Gliomas. Neuro Oncol 2020<br>319\u4f8b\u306eIDH\u5909\u7570\u578b\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u661f\u7d30\u80de\u816b\u3082\u4e4f\u7a81\u8d77\u81a0\u816b\u306a\u3069\u3082\u542b\u3080\uff09\u306b\u7a4d\u6975\u7684\u306a\u6458\u51fa\u8853\u304c\u8a66\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f6.8\u5e74\u3067190\u4f8b (60%)\u3067progression \u518d\u71c3\u304c\u751f\u3058\u307e\u3057\u305f\u300235%\u306e\u60a3\u8005\u3055\u3093\u3067supratotal resection\u304c\u3067\u304dprogression\u306f6\u4f8b (5.4%\uff09\u3067\u3057\u305f\u3002\u4e00\u65b9\u3067\uff0c\u90e8\u5206\u6458\u51fa\u3084\u4e9c\u5168\u6458\u51fa\u306e\u60a3\u8005\u3055\u3093\u3067\u306f82%\u306bprogression\u304c\u751f\u3058\u307e\u3057\u305f\u3002supratotal resection\u306e\u60a3\u8005\u3055\u3093\u3067\u306f92\u30f6\u6708\u306e\u6642\u70b9\u3067PFS 94%\u3067\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306fIDH\u4ee5\u5916\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3084\u816b\u760d\u30b0\u30ec\u30fc\u30c9\u306b\u306f\u512a\u4f4d\u306a\u95a2\u9023\u6027\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u8853\u5f8c\u8a55\u4fa1\u306eMRI\u306f48\u6642\u9593\u4ee5\u5185\u306b\u3059\u308b<\/h4>\n\n\n\n<p>Bette S: Patterns and time dependence of unspecific enhancement in postoperative magnetic resonance imaging after glioblastoma resection. World Neurosurg. 2016.<br>\u624b\u8853\u5f8c45\u6642\u9593\u4ee5\u5185\u3067\u306f\u865a\u8840\u3042\u308b\u3044\u306f\u624b\u8853\u53cd\u5fdc\u6027\u306e\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u6240\u898b\u306f17.9%\u306b\u8a8d\u3081\u3089\u308c\uff0c45\u6642\u9593\u5f8c\u3060\u306834.1%\u306b\u5897\u3048\u307e\u3059\u3002\u7dda\u72b6\u306e\u5897\u5f37\u50cf\u306f\u624b\u8853\u53cd\u5fdc\u6027\u306e\u3082\u306e\u3060\u3068\u308f\u304b\u308a\u6b8b\u5b58\u816b\u760d\u3068\u306e\u533a\u5225\u304c\u53ef\u80fd\u3067\u3059\u3002\u6b8b\u5b58\u816b\u760d\u306e\u8a55\u4fa1\u306f\u624b\u8853\u5f8c\u306e\u65e9\u3044\u6642\u671f\u306bMRI\u3092\u884c\u3063\u305f\u65b9\u304c\u6b63\u78ba\u306b\u5224\u65ad\u3067\u304d\u308b\u3068\u3044\u3046\u7d50\u8ad6\u3067\u3059\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u6587\u732e<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"refAuthors\">Ellingson BM, et al.\u00a0<\/span><span class=\"refTitle\">Consensus recommendations for a standardized brain tumor imaging protocol in clinical trials.\u00a0<\/span><span class=\"refSeriesTitle\">Neuro Oncol<\/span>\u00a0<span class=\"refSeriesVolume\">17<\/span>:\u00a0<span class=\"refPages\">1188\u20131198, 2015<\/span><\/li>\n\n\n\n<li><span class=\"refAuthors\">Goz\u00e9, C, Blonski, M, Le Maistre, G et al. <\/span><span class=\"refTitle\">Imaging growth and isocitrate dehydrogenase 1 mutation are independent predictors for diffuse low-grade gliomas. <\/span><span class=\"refSeriesTitle\">Neuro Oncol 16,<\/span>\u00a0<span class=\"refSeriesDate\">2014<\/span><\/li>\n\n\n\n<li>Mitchell DA, et al.: Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature 519: 366\u2013369, 2015<\/li>\n\n\n\n<li>Mohammadi AM, et al.: Use of high-field intraoperative magnetic resonance imaging to enhance the extent of resection of enhancing and nonenhancing gliomas. Neurosurgery 74: 339-348, 2014<\/li>\n\n\n\n<li>Pallud, J, Blonski, M, Mandonnet, E et al.\u00a0Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas.\u00a0<em>Neuro Oncol<\/em> <strong>15<\/strong>, 2013<\/li>\n\n\n\n<li>Pichlmeier U, et al. ALA Glioma Study Group: Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients. Neuro Oncol. 10:1025-1034, 2008<\/li>\n\n\n\n<li>Wen PY, et al.: Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28: 1963\u20131972, 2010<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6ce8\u610f\uff01\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b \u3057\u3093\u3051\u3044\u3053\u3046\u3057\u3085\uff09\u306f\u75c5\u540d\u3067\u306f\u3042\u308a\u307e\u305b\u3093 \u6700\u5927\u306e\u7279\u5fb4\u306f\u8133\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u5e83\u304c\u308b\u3053\u3068\u3067\u3059 \u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c92\u306e\u7d44\u7e54\u50cf\u3067\u3059\u3002\u9ec4\u8272\u3044\u77e2\u5370\u306f\u795e\u7d4c\u7d30\u80de\u3067\u5927\u578b\u3067\u3059\u3002\u70b9\u306e\u3088\u3046\u306b\u898b\u3048\u308b\u306e\u304c\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u30b0\u30ea\u30aa\u30fc [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1794","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=1794"}],"version-history":[{"count":249,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1794\/revisions"}],"predecessor-version":[{"id":23960,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1794\/revisions\/23960"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=1794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=1794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=1794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}