{"id":1673,"date":"2013-01-04T16:48:23","date_gmt":"2013-01-04T07:48:23","guid":{"rendered":"\/sawamura\/?p=1673"},"modified":"2023-05-08T09:33:48","modified_gmt":"2023-05-08T00:33:48","slug":"gliadel","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliadel\/","title":{"rendered":"\u30ae\u30ea\u30a2\u30c7\u30eb\uff0c\u30b0\u30ea\u30a2\u30c7\u30eb\u30fb\u30a6\u30a7\u30d5\u30a1\u30fc"},"content":{"rendered":"<h5>GLIADEL carmustine wafer (BCNU wefer)<\/h5>\n<ul>\n<li>\u30ae\u30ea\u30a2\u30c7\u30eb\u306f\u65e5\u672c\u3067\u306e\u5546\u54c1\u540d\u3067\uff0c\u82f1\u8a9e\u3067\u306fgliadel wafer <strong><span style=\"color: #ff0000;\">\u30b0\u30ea\u30a2\u30c7\u30eb\u30fb\u30a6\u30a7\u30d5\u30a1\u30fc<\/span><\/strong>\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>2013\u5e74\u306b\u65e5\u672c\u3067\u4fdd\u967a\u8a3a\u7642\u9069\u5fdc\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u304c\uff0c\u305d\u306e\u6642\u70b9\u3067\u958b\u767a\u3057\u305f\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306e\u4f7f\u7528\u306f\u3059\u3067\u306b\u4e0b\u706b\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f<\/li>\n<li><span style=\"color: #000080;\"><strong>\u60aa\u6027\u8133\u816b\u760d\u306e\u624b\u8853\u4e2d<\/strong><\/span>\u306b\u4f7f\u3044\u307e\u3059<\/li>\n<li>\u624b\u8853\u4e2d\u306b\uff0c\u816b\u760d\u3092\u3068\u3063\u305f\u5f8c\u306e\u8133\u306e\u4e2d\u306b\u7f6e\u3044\u3066\u304f\u308b\u3068\uff0c\u30ae\u30ea\u30a2\u30c7\u30eb\u304c\u53d6\u308a\u6b8b\u3057\u305f\u60aa\u6027\u7d30\u80de\u3092\u6bba\u3059\u529b\u304c\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3<strong><span style=\"color: #ff0000;\">\u8133\u5185\u7559\u7f6e\u7528\u5264 interstitial chemotherapy\u00a0<\/span>\u3068\u3044\u3044\u307e\u3059<\/strong><\/li>\n<li>\u958b\u982d\u624b\u8853\u3067\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u6458\u51fa\u3057\u3066\uff0c\u305d\u306e\u7a74\uff08\u6458\u51fa\u8154\uff09\u306b\u8cbc\u4ed8\u3051\u3066\u7f6e\u3044\u3066\u304f\u308b\u3068\u3044\u3046\u4f7f\u3044\u65b9\u3092\u3057\u307e\u3059<\/li>\n<li>\u7c73\u56fd\u30671970\u5e74\u4ee3\u304b\u3089\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u30cb\u30c8\u30ed\u30bd\u30a6\u30ec\u30a2\u7cfb\u306e<span style=\"color: #000080;\"><strong>BCNU\uff08\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3 carmustine\uff09\u3068\u3044\u3046\u3082\u306e\u3067\u65b0\u3057\u3044\u85ac\u5264\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\">\u30dc\u30ea\u30d5\u30a7\u30d7\u30ed\u30b5\u30f3\u3068\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3\u3092\u6df7\u305c\u3066\u3042\u308b\u306e\u3067\uff0c\u816b\u760d\uff08\u30b0\u30ea\u30aa\u30fc\u30de\uff09\u306e\u4e2d\u306b\u7f6e\u3044\u3066\u304f\u308b\u3068<span style=\"color: #000080;\"><strong>\u3086\u3063\u304f\u308a\u6eb6\u3051\u3066\u9577\u3044\u9593\u306b\u308f\u305f\u3063\u3066\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee<\/strong><\/span>\u3059\u308b\u3068\u3044\u3046\u7406\u8ad6\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #000080;\"><strong>\u9069\u5fdc\u75c7\u306f\u60aa\u6027\u795e\u7d4c\u81a0\u816b\uff08\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\uff09<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u521d\u56de\u624b\u8853\u306b\u4f7f\u3046\u5834\u5408\u306b\u306f\uff0c\u624b\u8853\u4e2d\u75c5\u7406\u8a3a\u65ad\uff08\u8fc5\u901f\u75c5\u7406\u8a3a\u65ad\uff09\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u624b\u8853\u4e2d\u306b<a title=\"\u30b0\u30ec\u30fc\u30c9 \u60aa\u6027\u5ea6\u3068\u306f\" href=\"\/sawamura\/braintumors\/malignancy\/\">\u30b0\u30ec\u30fc\u30c9\uff13\u304b\uff14\u306e\u30b0\u30ea\u30aa\u30fc\u30de<\/a>\u304c\u7591\u308f\u308c\u308c\u3070\u4f7f\u7528\u53ef\u80fd\u3068\u3044\u3046\u3053\u3068\u3067\u3059<\/strong><\/span><\/li>\n<li>\u6b8b\u5ff5\u306a\u304c\u3089\uff0c\u30ae\u30ea\u30a2\u30c7\u30eb\u5358\u72ec\u3067\u60aa\u6027\u816b\u760d\u304c\u6cbb\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u307e\u305a\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u624b\u8853\u4e2d\u306b\u307b\u307c\u5168\u3066\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u6458\u51fa\u3067\u304d\u305f gross total removal \u3068\u5224\u65ad\u3055\u308c\u305f\u6642\u306b\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<li>\u898b\u305f\u76ee\u3067\u660e\u3089\u304b\u306b\u816b\u760d\u304c\u6b8b\u3063\u3066\u3044\u308b\u72b6\u614b\u3067\u306f\u52b9\u679c\u306f\u671f\u5f85\u3067\u304d\u307e\u305b\u3093<\/li>\n<li>\u521d\u767a\u306e\u5834\u5408\u3082\u518d\u767a\u306e\u5834\u5408\u3082\uff0c\u751f\u5b58\u671f\u9593\u306e2\u30f6\u6708\u307b\u3069\u306e\u5ef6\u9577\u52b9\u679c\u304c\u3042\u308b\u3068\u3044\u3046\u3068\u3053\u308d\u3067\u3057\u3087\u3046\u304b<\/li>\n<li>\u81a0\u82bd\u816b\u3067\u306f\uff0c\u307b\u307c\u5168\u6458\u51fa\u3067\u304d\u305f\u3068\u3044\u3046\u72b6\u614b\u3067\u4f7f\u7528\u3057\u306a\u3044\u3068\u6709\u52b9\u6027\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u85ac\u4fa1\u306f\u4e00\u679a7.7mg\u306715\u4e076400\u5186\u3067\u3059\u304b\u3089\uff0c\uff11\u624b\u8853\u3042\u305f\u308a8\u679a\u3067\u304a\u3088\u305d124\u4e07\u5186\u3067\u3059<\/li>\n<\/ul>\n<h5>2017\u5e74\u6642\u70b9\u3067\u306f\u3042\u307e\u308a\u4f7f\u7528\u3055\u308c\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/h5>\n<h5>\u7406\u7531\u306f\uff0c\u3042\u307e\u308a\u52b9\u679c\u304c\u306a\u3044\u3068\u81e8\u5e8a\u533b\u304c\u8003\u3048\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002\u307e\u305f\u4ed6\u306e\u85ac\u5264\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u306e\u5b89\u5168\u6027\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u4ed6\u306b\u5316\u5b66\u7642\u6cd5\u304c\u4f7f\u7528\u3067\u304d\u306a\u3044\u60a3\u8005\u3055\u3093\u306a\u3069\u3067\u4f7f\u308f\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/h5>\n<h4>\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09<\/h4>\n<p>\u91cd\u5927\u306a\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u3051\u3044\u308c\u3093\u767a\u4f5c\uff0c\u8133\u6d6e\u816b<\/strong><\/span>\uff0c\u982d\u84cb\u5185\u5727\u4e0a\u6607\uff0c\u6c34\u982d\u75c7\uff0c\u8133\u30d8\u30eb\u30cb\u30a2\uff0c\u5275\u50b7\u6cbb\u7652\u4e0d\u826f\uff08\u9ac4\u6db2\u6f0f\uff09\uff0c\u611f\u67d3\u75c7\uff0c\u8840\u6813\u585e\u6813\u75c7\uff0c\u51fa\u8840\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3044\u305a\u308c\u3082\u983b\u5ea6\u306f\u3068\u3066\u3082\u4f4e\u3044\u3082\u306e\u3067\u3059\u3057\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u3068\u624b\u8853\u306b\u8a73\u3057\u3044\u8133\u5916\u79d1\u533b\u3067\u3042\u308c\u3070\u4e88\u60f3\u3068\u5bfe\u51e6\u304c\u3067\u304d\u308b\u7a0b\u5ea6\u306e\u3082\u306e\u3067\u3059\u3002\u30ae\u30ea\u30a2\u30c7\u30eb\u3092\u7559\u7f6e\u3057\u305f\u8133\u306e\u5468\u56f2\u304c\u6d6e\u816b\u3067\u816b\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30ae\u30ea\u30a2\u30c7\u30eb\u304c\u76ae\u819a\u306b\u89e6\u308c\u308b\u3068\u71b1\u50b7\u3068\u8272\u7d20\u6c88\u7740\u3092\u751f\u3058\u308b\u304f\u3089\u3044\u3067\u3059\u304b\u3089\uff0c<span style=\"color: #000080;\"><strong>\u5c40\u6240\u8133\u6d6e\u816b\u304c\u5897\u60aa\u3059\u308b<\/strong><\/span>\u53ef\u80fd\u6027\u3092\u77e5\u3063\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h4>\u30ae\u30ea\u30a2\u30c7\u30eb\u306e\u4f7f\u3044\u65b9<\/h4>\n<p>\u30de\u30a4\u30ca\u30b915\u2103\u4ee5\u4e0b\u3067\u4fdd\u5b58\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5ba4\u6e29\u306b\u7f6e\u3044\u305f\u3089\uff16\u6642\u9593\u4ee5\u5185\u306b\u4f7f\u7528\u3067\u3059\u304b\u3089\uff0c\u51b7\u6e29\u4fdd\u5b58\u304c\u3067\u304d\u306a\u3044\u75c5\u9662\u3067\u306f\u4f7f\u7528\u304c\u3067\u304d\u307e\u305b\u3093\u3002<br \/>\n\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u624b\u8853\u6458\u51fa\u3057\u3066\uff0c\u5207\u9664\u9762\u3092\u8986\u3046\u3088\u3046\u306b\u30ae\u30ea\u30a2\u30c7\u30eb\u3092\u6577\u304d\u3064\u3081\u307e\u3059\u3002 \u4e00\u888b\u306b8\u679a\u306e\u5186\u76e4\u72b6\u306e\u30ae\u30ea\u30a2\u30c7\u30eb\uff08\uff11\u679a\u306b\u3064\u3044\u3066\u30ab\u30eb\u30e0\u30b9\u30c1\u30f37.7mg\uff09\u304c\u5165\u3063\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u4f7f\u7528\u679a\u6570\u306f\u6700\u5927\u3067\uff18\u679a\u3067\u3059\u3002<\/p>\n<h5>\u6587\u732e<\/h5>\n<h4><span class=\"text surname\">\u5973\u6027\u3068\u82e5\u5e74\u8005\u306b\u6709\u52b9\u6027\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b<\/span><\/h4>\n<p><span class=\"text surname\">Champeaux-Depond C:\u00a0<\/span><span class=\"title-text\">Newly Diagnosed High-Grade Glioma Surgery with Carmustine Wafers Implantation. A\u00a0Long-Term Nationwide Retrospective Study. World Neurosurg 2023<br \/>\n\u30d5\u30e9\u30f3\u30b9\u30671,608\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u4f7f\u7528\u3055\u308c\u305d\u306e\u89e3\u6790\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u30ae\u30ea\u30a2\u30c7\u30eb\u3092\u4f7f\u7528\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u306e5\u5e74\u5168\u751f\u5b58\u5272\u5408\u306f10.7%\u3067\u3042\u308a\uff0c\u82e5\u5e74\u8005\u3068\u5973\u6027\u306b\u3088\u308a\u6709\u52b9\u6027\u304c\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<h4 data-test=\"article-title\">\u6295\u4e0e\u5f8c\u306bFLAIR\u753b\u50cf\u3067\u4e00\u904e\u6027\u306b\u708e\u75c7\u6027\u6d6e\u816b\u50cf\u304c\u5f37\u304f\u51fa\u308b\u75c7\u4f8b\u3067\u306f\uff0c\u4e88\u5f8c\u306e\u6539\u5584\u304c\u3042\u308b<\/h4>\n<p class=\"c-article-title\" data-test=\"article-title\">Haim O: The clinical significance of radiological changes associated with gliadel implantation in patients with recurrent high grade glioma. Scientific Reports 2023<br \/>\n\u5927\u304d\u306a\u816b\u760d\uff0c\u6458\u51fa\u8154\u306e\u5927\u304d\u306a\u3082\u306e\u306b\u306f\u52b9\u304d\u3065\u3089\u3044\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u9006\u306b\uff0c\u6295\u4e0e\u5f8c\u306bFLAIR\u753b\u50cf\u3067\u4e00\u904e\u6027\u306b\u708e\u75c7\u6027\u6d6e\u816b\u50cf\u304c\u5f37\u304f\u51fa\u308b\u75c7\u4f8b\u3067\u306f\uff0c\u751f\u547d\u4e88\u5f8c\u306e\u5ef6\u9577\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\u3067\u306e\u6210\u7e3e<\/h4>\n<p align=\"left\">Duntze J, et al: Implanted carmustine wafers followed by concomitant radiochemotherapy to treat newly diagnosed malignant gliomas: Prospective,observational, multicenter study on 92cases. Ann Surg Oncol 2012<br \/>\n\u30d5\u30e9\u30f3\u30b9\u306e17\u65bd\u8a2d\u304b\u3089\u306e\u5831\u544a\u3067\uff0c92\u4eba\u306e\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u521d\u56de\u624b\u8853\u3067\u30b0\u30ea\u30a2\u30c7\u30eb\u304c\u4f7f\u7528\u3055\u308c\uff0c\u8853\u5f8c\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u30b0\u30ea\u30a2\u30c7\u30eb\u306e\u526f\u4f5c\u7528\u3068\u3057\u3066\u3068\u3089\u3048\u3089\u308c\u305f\u4f8b\u306f\uff0c5\u4f8b\u306e\u91cd\u7be4\u306a\u611f\u67d3\u75c7\u3067\u3059\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f10.5\u30f6\u6708\uff0c\u5168\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f18.8\u30f6\u6708\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u306f\u304b\u306a\u308a\u9577\u3044\u3068\u8a00\u3048\u307e\u3059\u304c\uff0c\u7121\u4f5c\u70ba\u8a66\u9a13\u3067\u306f\u306a\u3044\u306e\u3067\u8a55\u4fa1\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h4 align=\"left\">\u624b\u8853\u3067\u307b\u307c\u5168\u6458\u51fa\u3067\u304d\u3066\u3044\u306a\u3044\u3068\u52b9\u679c\u306f\u671f\u5f85\u3067\u304d\u306a\u3044<\/h4>\n<p>Stummer W, et al.: Cytoreductive\u00a0surgery\u00a0of\u00a0glioblastoma\u00a0as the\u00a0key\u00a0to\u00a0successful\u00a0adjuvant therapies: new arguments in an old discussion. Acta Neurochir (Wien).\u00a02011<br \/>\n90%\u4ee5\u4e0a\u6458\u51fa\u3067\u304d\u306a\u3044\u81a0\u82bd\u816b\u306e\u4f8b\u3067\u306f\uff0c\u30ae\u30ea\u30a2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3082\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u306f\u306a\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u9006\u306b\uff0c90\uff05\u4ee5\u4e0a\u306e\u6458\u51fa\u304c\u3067\u304d\u305f\u5834\u5408\u306b\u306f2\u30f6\u6708\u307b\u3069\u306e\u5ef6\u9577\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306f\u4f4e\u3044\u8ad6\u6587\u3067\u3059\u3002<\/p>\n<h4>\u30cf\u30f3\u30d6\u30eb\u30b0\u5927\u5b66Westphal\u5148\u751f\u306e\u6709\u540d\u306a\u8ad6\u6587<\/h4>\n<p align=\"left\">Westphal M, et al: A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma.\u00a0Neuro Oncol 5:79-88, 2003<br \/>\n240\u4eba\u306e\u521d\u767a\u795e\u7d4c\u81a0\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\u30b0\u30ea\u30a2\u30c7\u30eb\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002\u624b\u8853\u5f8c\u306b\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30b0\u30ea\u30a2\u30c7\u30eb\u3092\u521d\u56de\u624b\u8853\u306b\u4f7f\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f13.9\u30f6\u6708\uff0c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f11.6\u30f6\u6708\u3067\u3057\u305f\u3002<\/p>\n<h3>\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3 BCNU\u306e\u57fa\u790e\u77e5\u8b58<\/h3>\n<p align=\"left\">\u30ab\u30eb\u30e0\u30b9\u30c1\u30f3 BCNU \u306f\uff0c\u30cb\u30c8\u30ed\u30bd\u30a6\u30ec\u30a2\u7cfb\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3067\u3001\u7d30\u80de\u5185DNA\u3092\u30a2\u30eb\u30ad\u30eb\u5316\u3057\u6838\u9178\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5468\u671f\u306e\u505c\u6b62\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3057\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u30021979\u5e74\u306b\u6ce8\u5c04\u5264\u3068\u3057\u3066\u7c73\u56fd\u306b\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u8102\u6eb6\u6027\u3067\u8840\u6db2\u8133\u95a2\u9580\u306e\u901a\u904e\u6027\u304c\u826f\u3044\u3053\u3068\u304b\u3089\u3001\u6b27\u7c73\u3067\u306f1980\u5e74\u4ee3\u30681990\u5e74\u4ee3\u306b\uff0c\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u3067\u306f\u6700\u3082\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u85ac\u5264\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u7d30\u80de\u3092\u6b7b\u6ec5\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u9ad8\u7528\u91cf\u304c\u5fc5\u8981\u306a\u305f\u3081\u3001\u9aa8\u9ac4\u6291\u5236\u3084\u80ba\u6bd2\u6027\u306a\u3069\u306e\u5168\u8eab\u6027\u306e\u526f\u4f5c\u7528\u304c\u3042\u308a\uff0c\u8840\u4e2d\u534a\u6e1b\u671f\u304c\u7d0415\u5206\u3068\u77ed\u3044\u3053\u3068\u304c\u6b20\u70b9\u3067\u3057\u305f\u3002\u30ae\u30ea\u30a2\u30c7\u30eb\u306f\u5c40\u6240\u9ad8\u6fc3\u5ea6\u6295\u4e0e\u3067\u3053\u306e\u6b20\u70b9\u3092\u514b\u670d\u3057\u3088\u3046\u3068\u3044\u3046\u767a\u60f3\u304b\u3089\u4f5c\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n1970\u5e74\u4ee3\u5f53\u6642\u304b\u3089\u65e5\u672c\u306f\u30ac\u30e9\u30d1\u30b4\u30b9\u5316\u3057\u3066\u304a\u308a\uff0c\u985e\u4f3c\u306e\u30cb\u30c9\u30e9\u30f3 ACNU \u304c\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u306e\u3067\uff0c\u6b27\u7c73\u306e\u6210\u7e3e\u3068\u65e5\u672c\u306e\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u6210\u7e3e\u306e\u6bd4\u8f03\u691c\u8a0e\u304c\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8133\u816b\u760d\u306e\u9818\u57df\u3067\u306fBCNU\uff0cACNU\u3068\u3082\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6c4e\u7528\u5316\u3068\u3068\u3082\u306b\u9759\u8108\u6ce8\u5c04\u3067\u306f\u4f7f\u7528\u3055\u308c\u306a\u304f\u306a\u3063\u305f\u6297\u304c\u3093\u5264\u3067\u3059\u3002<\/p>\n<p style=\"text-align: center;\"><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gliadel.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1968\" title=\"gliadel\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2013\/01\/gliadel.jpg\" alt=\"\" width=\"556\" height=\"404\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLIADEL carmustine wafer (BCNU wefer) \u30ae\u30ea\u30a2\u30c7\u30eb\u306f\u65e5\u672c\u3067\u306e\u5546\u54c1\u540d\u3067\uff0c\u82f1\u8a9e\u3067\u306fgliadel wafer \u30b0\u30ea\u30a2\u30c7\u30eb\u30fb\u30a6\u30a7\u30d5\u30a1\u30fc\u3068\u3044\u3044\u307e\u3059 2013\u5e74\u306b\u65e5\u672c\u3067\u4fdd\u967a\u8a3a\u7642\u9069\u5fdc\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1673","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=1673"}],"version-history":[{"count":32,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1673\/revisions"}],"predecessor-version":[{"id":21494,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/1673\/revisions\/21494"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=1673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=1673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=1673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}