{"id":166,"date":"2012-04-19T02:10:47","date_gmt":"2012-04-18T17:10:47","guid":{"rendered":"\/sawamura\/wp\/?p=166"},"modified":"2019-11-24T11:53:38","modified_gmt":"2019-11-24T02:53:38","slug":"desmoinfantile","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/desmoinfantile\/","title":{"rendered":"\u7dda\u7dad\u5f62\u6210\u6027\u4e73\u5150\u661f\u7d30\u80de\u816b DIA\uff0f\u795e\u7d4c\u7bc0\u81a0\u816b DIG"},"content":{"rendered":"<h5>\u7dda\u7dad\u5f62\u6210\u6027\u4e73\u5150\u661f\u7d30\u80de\u816b\uff0f\u795e\u7d4c\u7bc0\u81a0\u816b\u306b\u3064\u3044\u3066 DIA\/DIG<br \/>\ndesmoplastic infantile astrocytoma DIA\/ ganglioglioma DIG<\/h5>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">\u4e73\u5e7c\u5150\u306b\u3067\u304d\u308b\u3068\u3066\u3082\u3081\u305a\u3089\u3057\u3044\u826f\u6027\u816b\u760d<\/span><\/strong>\u3067\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u307b\u3068\u3093\u3069\u304c2\u624d\u4ee5\u4e0b<\/strong><\/span>\u306b\u751f\u3058\u307e\u3059<\/li>\n<li>\u77ed\u671f\u9593\u306b<strong><span style=\"color: #ff0000;\">\u982d\u56f2\u304c\u7570\u5e38\u306b\u5927\u304d\u304f\u306a\u308b<\/span><\/strong>\uff0c\u5927\u6cc9\u9580\uff08\u982d\u306e\u3066\u3063\u307a\u3093\u306e\u9aa8\u306e\u306a\u3044\u3068\u3053\u308d\uff09\u304c\u81a8\u3089\u3093\u3067\u304f\u308b\u306a\u3069\u3067\u6c17\u4ed8\u304b\u308c\u307e\u3059<\/li>\n<li>\u305d\u308c\u304b\u3089\uff0c<strong><span style=\"color: #ff0000;\">\u3050\u3063\u305f\u308a\u3057\u3066\u5143\u6c17\u304c\u306a\u304f\u306a\u3063\u305f\u308a<\/span><\/strong>\uff0c\u5614\u5410\u3057\u305f\u308a\uff0c\u773c\u306e\u52d5\u304d\u304c\u60aa\u304f\u306a\u3063\u305f\u308a\uff08\u773c\u304c\u4e0b\u306e\u65b9\u306b\u5411\u304f\uff09\u306a\u3069\u3057\u307e\u3059<\/li>\n<li>\u9ebb\u75fa\u3084\u3066\u3093\u304b\u3093\u767a\u4f5c\uff08\u3051\u3044\u308c\u3093\uff09\u3092\u751f\u3058\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u5927\u8133\u306e\u8868\u9762\u306b\u3067\u304d\u3066\uff0c\u3068\u3066\u3082\u5927\u304d\u306a\u816b\u760d\u3067\uff0c\u5927\u304d\u306a\u306e\u3046\u80de\uff08\u6db2\u4f53\u304c\u305f\u307e\u308b\uff09\u3092\u4f34\u3044\u307e\u3059<\/li>\n<li>\u753b\u50cf\u304b\u3089\u306fPNET\u3068\u9593\u9055\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u6c17\u3092\u3064\u3051\u3066<\/li>\n<li>\u816b\u760d\u306e\u7279\u5fb4\u306f\uff0c<strong><span style=\"color: #ff0000;\">\u4e73\u5150\u306e\u5927\u8133\u306e\u8868\u9762\u306b\u3042\u308b\u5de8\u5927\u306a\u816b\u760d<\/span><\/strong>\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u3068\u306b\u304b\u304f\uff0c\u3068\u3066\u3082\u5927\u304d\u3044\u306e\u3067\u8133\u5916\u79d1\u306e\u5148\u751f\u3082\u3073\u3063\u304f\u308a\u3057\u307e\u3059<\/span><\/strong><\/li>\n<li>\u6db2\u4f53\u306e\u305f\u307e\u3063\u3066\u3044\u308b\u306e\u3046\u80de\u304c\u5927\u90e8\u5206\u3067\u3059<\/li>\n<li>\u4e0d\u6b63\u5f62\u306b\u9020\u5f71\u5264\u3067\u5897\u5f37\u3055\u308c\u3066\u767d\u304f\u6620\u308b\u584a\u304c\u898b\u3048\u307e\u3059\u304c\uff0c\u305d\u308c\u304c\u672c\u4f53\u3067\u3059<\/li>\n<li>\u624b\u8853\u3067\u5168\u90e8\u53d6\u308c\u308c\u3070\u6cbb\u308a\u307e\u3059\u3057\uff0c\u518d\u767a\u306e\u983b\u5ea6\u306f\u4f4e\u3044\u3067\u3059<\/li>\n<li>\u305f\u3068\u3048\u5c11\u3057\u53d6\u308a\u6b8b\u3057\u3066\u3082\uff0c\u3059\u3050\u306b\u306f\u5316\u5b66\u7642\u6cd5\uff08\u5236\u304c\u3093\u5264\uff09\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u306a\u3069\u3092\u3057\u306a\u3044\u3067\u3088\u3046\u3059\u3092\u307f\u307e\u3059<\/li>\n<li>\u53d6\u308a\u6b8b\u3057\u305f\u816b\u760d\u304c\uff0c\u307b\u3063\u3066\u304a\u3044\u3066\u3082\u81ea\u7136\u306b\u5c0f\u3055\u304f\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff08\u81ea\u7136\u9000\u7e2e\uff09<\/li>\n<li>\u6b8b\u3063\u305f\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u304f\u308b\u5834\u5408\u306b\u306f\uff0c\u307e\u305f\u958b\u982d\u624b\u8853\u3067\u6458\u51fa\u3057\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3084\u5316\u5b66\u7642\u6cd5\u306f\u3054\u304f\u9650\u3089\u308c\u305f\u4f8b\u3067\u5fc5\u7528\u3067\u3059\uff0c\u614e\u91cd\u306b\u691c\u8a0e\u3057\u307e\u3057\u3087\u3046<\/li>\n<li>\u826f\u6027\u306e\u816b\u760d\u3067<strong><span style=\"color: #ff0000;\">WHO \u30b0\u30ec\u30fc\u30c9\uff11<\/span><\/strong>\uff08\u3082\u3063\u3068\u3082\u7d4c\u904e\u306e\u826f\u3044\u816b\u760d\uff09\u3067\u3059<\/li>\n<li>\u3067\u3082\uff0c\u4e73\u5150\u306e\u5de8\u5927\u306a\u8133\u816b\u760d\u306a\u306e\u3067\u624b\u8853\u306f\u7c21\u5358\u3067\u306f\u306a\u3044\u3067\u3059\u3057\uff0c\u624b\u8853\u5408\u4f75\u75c7\uff08\u6b7b\u4ea1\u4f8b\u3084\u91cd\u3044\u8133\u640d\u50b7\uff09\u306e\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059<\/li>\n<li>\u4e73\u5150\u3067\u306f10%\u304f\u3089\u3044\u3067\u6cbb\u7642\u5408\u4f75\u75c7\u3084\u9ac4\u6db2\u64ad\u7a2e\u3067\u547d\u3092\u5931\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3068\u306e\u8a18\u8f09\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u5927\u8133\u306e\u8868\u9762\u306b\u50b7\u304c\u6b8b\u308a\u307e\u3059\u306e\u3067\uff0c<span style=\"background-color: #ffffff; color: #ff0000;\"><strong>\u75c7\u5019\u6027\u3066\u3093\u304b\u3093<\/strong><\/span>\uff08\u3051\u3044\u308c\u3093\u767a\u4f5c\uff09\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\u304c\u751f\u3058\u305f\u3089\uff0c\u5c0f\u5150\u79d1\u306e\u5148\u751f\u306b\u6297\u3066\u3093\u304b\u3093\u85ac\u3092\u51e6\u65b9\u3057\u3066\u3044\u305f\u3060\u3044\u3066\u767a\u4f5c\u3092\u6b62\u3081\u307e\u3059<\/li>\n<\/ul>\n<hr \/>\n<h4>2\u6b73\u306e\u5b50\u3069\u3082\u306e\u4f8b<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-5938\" title=\"diadigka1\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka1-298x300.jpg 298w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka1.jpg 396w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-5939\" title=\"diadigka3\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka41.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-5941\" title=\"diadigka4\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/diadigka41-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>2\u6b73\u306e\u6642\u306b\u53f3\u306e\u7247\u9ebb\u75fa\u3068\u610f\u8b58\u969c\u5bb3\u3067\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u624b\u8853\u3067\u304d\u308c\u3044\u306b\u3068\u308c\u3066\uff0c20\u5e74\u7d4c\u3061\u307e\u3059\u304c\u518d\u767a\u306f\u3042\u308a\u307e\u305b\u3093\u3057\uff0c\u904b\u52d5\u9ebb\u75fa\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u753b\u50cf\u3092\u898b\u308b\u3068\u5de6\u306e\u4e00\u6b21\u904b\u52d5\u91ce\u304c\u4fb5\u3055\u308c\u3066\u3044\u3066\uff0c\u9ebb\u75fa\u304c\u6cbb\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u4fe1\u3058\u3089\u308c\u306a\u3044\u306e\u3067\u3059\u304c\uff0c2\u6b73\u4ee5\u4e0b\u306e\u5c0f\u3055\u306a\u5b50\u3069\u3082\u306e\u9ebb\u75fa\u306f\u6cbb\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4e73\u5e7c\u5150\u306e\u3053\u306e\u816b\u760d\u306f\u7a4d\u6975\u7684\u306a\u6458\u51fa\u3092\u884c\u3063\u305f\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4>\u5c02\u9580\u7684\u77e5\u8b58<\/h4>\n<ul>\n<li>\u6025\u6fc0\u306a\u982d\u56f2\u62e1\u5927\u306a\u3069\uff0c\u4e73\u5150\u7279\u6709\u306e\u982d\u84cb\u5185\u5727\u4ea2\u9032\u75c7\u72b6\u3067\u767a\u75c7\u3057\u307e\u3059<\/li>\n<li>\u591a\u304f\u306f\u751f\u5f8c\uff16\u30f6\u6708\u4ee5\u5185\uff0c\u304a\u305d\u304f\u3068\u308236\u30f6\u6708\u3067\u767a\u75c7\u3057\u307e\u3059<\/li>\n<li>\u5927\u8133\u306e\u8868\u5728\u6027\u816b\u760d\u3067\u3059<\/li>\n<li>\u4e73\u5150\u306e\u8edf\u819c\u4e0b\u795e\u7d4c\u4e0a\u76ae\u7d30\u80de\uff08\u4e0a\u8863\u4e0b\u661f\u7d30\u80de\uff09\u304b\u3089\u767a\u751f\u3059\u3057\u307e\u3059\u304c\uff0c\u5927\u8133\u76ae\u8cea\u3068\u8edf\u819c\u8d77\u6e90\u306e\u816b\u760d\u306e\u6027\u8cea\u3092\u6709\u3059\u308b\u306e\u3067\uff0c\u786c\u819c\u306b\u3057\u3070\u3057\u3070\u7652\u7740\u3057\u307e\u3059<\/li>\n<li>\u8133\u6e9d\u3078\u3068\u6d78\u6f64\u3057\u3066\u76ae\u8cea\u52d5\u8108\u306b\u7652\u7740\u3057\u305d\u308c\u3092\u5dfb\u304d\u8fbc\u3080\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u305d\u306e\u90e8\u5206\u306f\u624b\u8853\u3067\u306f\u7121\u7406\u306b\u6458\u51fa\u3057\u307e\u305b\u3093<\/li>\n<li>\u982d\u9802\u8449\u3068\u524d\u982d\u8449\u8868\u9762\u306b\u5e83\u304c\u308a\u6570\u30bb\u30f3\u30c1\u3092\u8d8a\u3048\u308b\u5de8\u5927\u306a\u306e\u3046\u80de\u6027\u816b\u760d\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u5927\u8133\u6df1\u90e8\u65b9\u5411\u3078\u98df\u3044\u8fbc\u3080\u306e\u3046\u80de\u304c\u3042\u308a\uff0c\u56fa\u5f62\u816b\u760d\u90e8\u5206\u306f\u7d50\u7bc0\u69d8\u306b\u8868\u5728\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u77f3\u7070\u5316\u306f\u73cd\u3057\u304f\uff0c\u4e00\u90e8\u304c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u3059<\/li>\n<\/ul>\n<h4>\u75c5\u7406\u6240\u898b<\/h4>\n<ul>\n<li>mixed neuronal-glial tumor\u3068\u547c\u3070\u308c\u308b\u4e00\u7fa4\u306e\u826f\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u5c5e\u3057\u307e\u3059<\/li>\n<li>\u81a0\u7d30\u80de\uff08glia)\u306e\u307f\u3067\u816b\u760d\u7d30\u80de\u304c\u5f62\u6210\u3055\u308c\u308b\u3082\u306e (DIA) \u3068\uff0c\u795e\u7d4c\u7d30\u80de (neuron, ganglion cell)\u3092\u6df7\u3058\u308b\u3082\u306e (DIG) \u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u81e8\u5e8a\u7d4c\u904e\u306f\u540c\u3058\u3067\u3042\u308a\u4e88\u5f8c\u306f\u6975\u3081\u3066\u3088\u3044\u306e\u3067\uff0c\u4e21\u8005\u3092\u81e8\u5e8a\u7684\u306b\u533a\u5225\u3059\u308b\u5fc5\u7528\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u306b\u306f\uff0c\u975e\u5e38\u306b<span style=\"color: #000080;\"><strong>\u9855\u8457\u306adesmoplasia \u7dda\u7dad\u5f62\u6210\uff08reticulin stain\uff09\u304c\u7279\u6709<\/strong><\/span>\u306e\u6240\u898b\u3067\u3059<\/li>\n<li>\u7d30\u80de\u5bc6\u5ea6\u306f\u4e2d\u7b49\u5ea6\u306b\u9ad8\u3044\u306e\u3067\u3059\u304cMIB-1\u306e\u67d3\u8272\u7387\u306f\u4f4e\u304f\uff0c\u7de9\u5f90\u306a\u5897\u5927\u50be\u5411\u3092\u6307\u793a\u3059\u308b\u6240\u898b\u3067\u3059<\/li>\n<li>glia\u6210\u5206\u306fGFAP\u967d\u6027\u3067\u7a81\u8d77\u306e\u76ee\u7acb\u3064\u661f\u7d30\u80de\u304c\u4e3b\u4f53\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u6df7\u5728\u3059\u308b\u795e\u7d4c\u7d30\u80de (neuronal differentiation) \u306e\u5bc6\u5ea6\u306f\u3055\u307e\u3056\u307e\u3067\uff0cgemistocyte\u69d8\u306e\u661f\u7d30\u80de\u304c\u307f\u3089\u308c\uff0c\u9ac4\u819c\u306b\u8fd1\u3044\u90e8\u5206\u3067\u306f\u81a0\u539f\u7dda\u7dad\u306e\u5897\u751f\u304c\u751f\u3058\u307e\u3059<\/li>\n<li>\u5c0f\u578b\u5186\u5f62\u7d30\u80de\u304c\u5bc6\u306b\u5b58\u5728\u3059\u308b\u90e8\u5206\u50cf (poorly undefferenciated cell nest) \u3092\u307f\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u3053\u308c\u3092anaplastic astrocytoma, gliosarcoma, PNET\u306a\u3069\u306e\u6df7\u5728\u3068\u8aa4\u3063\u3066\u306f\u306a\u308a\u307e\u305b\u3093<\/li>\n<li>PNET\u3068\u985e\u4f3c\u3057\u305f\u90e8\u5206\u75c5\u7406\u50cf\u306e\u8a3a\u65ad\u306f\u7279\u306b\u6ce8\u610f\u3092\u3088\u3046\u3059\u308b\u3082\u306e\u3067\u3059<\/li>\n<li>\u3053\u306e\u90e8\u5206\u306b\u306fMIB-1\u67d3\u8272\u7387\u304c\u9ad8\u304f\u30663%\u7a0b\u5ea6\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u7a00\u306b\u9ad8\u5ea6\u306e\u5206\u88c2\u50cf\u3092\u307f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059 (Duffner 1994)<\/li>\n<li>glial cell\u306fGFAP, vimentin\u967d\u6027\u3067\uff0cneuronal cell\u306fsynaptophysin, neurofilament protein, class III beta-tublin, MAP 2\u306a\u3069\u304c\u967d\u6027\u3067\u3059<\/li>\n<\/ul>\n<h4>\u6cbb\u7642\u306e\u65b9\u91dd<\/h4>\n<ul>\n<li>desmoplasia\u306e\u7a0b\u5ea6\u304c\u4f4e\u3044\u3082\u306e\u3067\u306fganglioglioma\u3068\u75c5\u7406\u8a3a\u65ad\u3055\u308c\u308b\u306e\u3067\u3059\u304c\uff0c\u81e8\u5e8a\u50cf\u304cDIG\u3067\u3042\u308c\u3070\u4e88\u5f8c\u306fDIG\u3068\u3057\u3066\u6cbb\u7642\u3092\u8003\u3048\u305f\u65b9\u304c\u3088\u3044\u3067\u3059<\/li>\n<li>\u5de8\u5927\u306a\u306e\u3046\u80de\u3092\u4f34\u3046\u306e\u3067\uff0c\u982d\u84cb\u5185\u5727\u4ea2\u9032\u3068\u610f\u8b58\u969c\u5bb3\u304c\u5f37\u3044\u4f8b\u3067\u306f\uff0c\u307e\u305a\u306e\u3046\u80de\u7a7f\u523a\u3067\u5ec3\u6db2\u30c9\u30ec\u30ca\u30fc\u30b8\u3057\u307e\u3059<\/li>\n<li>\u610f\u8b58\u3092\u6539\u5584\u3057\u3066\u5727\u6392\u3055\u308c\u305f\u6b63\u5e38\u8133\u306e\u5909\u79fb\u3092\u623b\u3057\u3066\u304b\u3089\uff0c\uff12\u671f\u7684\u306b\u816b\u760d\u7d50\u7bc0\u5207\u9664\u3092\u3057\u307e\u3059<\/li>\n<li>\u306e\u3046\u80de\u306f\u591a\u623f\u6027\u306e\u3053\u3068\u3082\u3042\u308a\uff0c\u5185\u5bb9\u6db2\u306f\u9ec4\u8272\u900f\u660e\u306a\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u5b9f\u8cea\u6210\u5206\u306f\u8133\u8868\u306b\u5b58\u5728\u3057\u3066\u786c\u304f\uff0c\u5468\u56f2\u306e\u9ac4\u819c\u3068\u7652\u7740\u3057\u307e\u3059\u304c\uff0c\u6b63\u5e38\u8133\u3068\u306f\u5883\u754c\u304c\u660e\u77ad\u306b\u898b\u3048\u307e\u3059<\/li>\n<li>\u8840\u7ba1\u6210\u5206\u306f\u816b\u760d\u7d50\u7bc0\u90e8\u306b\u8c4a\u5bcc\u3067\u3059\u304c\uff0c\u307b\u3068\u3093\u3069\u76ae\u8cea\u52d5\u8108\u304b\u3089\u306e\u6804\u990a\u679d\u3067\u3042\u308a\uff0c\u624b\u8853\u6642\u306b\u51fa\u8840\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u306f\u5bb9\u6613\u3067\u3059<\/li>\n<li>\u786c\u819c\u306b\u5f37\u304f\u7652\u7740\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u786c\u819c\u7d44\u7e54\u306b\u6d78\u6f64\u3057\u306a\u3044\u306e\u3067\uff0c\u5fc5\u8981\u3067\u3042\u308c\u3070\u7652\u7740\u90e8\u306e\u307f\u306e\u786c\u819c\u5207\u9664\u3092\u3057\u307e\u3059<\/li>\n<li>\u591a\u304f\u306e\u5834\u5408\u306f\u5168\u6458\u51fa\u3067\u304d\u308b\u816b\u760d\u3067\u3059<\/li>\n<li>eroquent brain\u3084\u76ae\u8cea\u52d5\u8108\u640d\u50b7\u304c\u751f\u3058\u305d\u3046\u306a\u6642\u306b\u306f\u90e8\u5206\u6458\u51fa\u306b\u3068\u3069\u3081\u3066\uff0c\u8853\u5f8c\u306f\u88dc\u52a9\u7642\u6cd5\u3092\u52a0\u3048\u306a\u3044\u3067\u7d4c\u904e\u3092\u898b\u307e\u3059<\/li>\n<li>\u5de8\u5927\u306a\u4e73\u5150\u8133\u816b\u760d\u306b\u3082\u95a2\u308f\u3089\u305a\u6b7b\u4ea1\u4f8b\u306e\u5831\u544a\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u3057\u304b\u3057\uff0c\u4e73\u5150\u306e\u958b\u982d\u8853\u306a\u306e\u3067\u624b\u8853\u5408\u4f75\u75c7\u3068\u3057\u3066\u306e\u5468\u8853\u671f\u6b7b\u4ea1\u304c\u3042\u308a\u3048\u307e\u3059<\/li>\n<li>\u5316\u5b66\u7642\u6cd5\u306e\u6709\u7528\u6027\u306f\u4e0d\u660e\u3067\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u518d\u71c3\uff0f\u518d\u767a\u3092\u7e70\u308a\u8fd4\u3059\u4f8b\u4ee5\u5916\u306b\u306f\u3057\u307e\u305b\u3093<\/li>\n<li>\u6587\u732e\u4e0a\u306f\u60aa\u5316\u4f8b\u3084\u60aa\u6027\u816b\u760d\u306b\u8ee2\u5316\u3057\u305f\u4f8b\u304c\u76ee\u7acb\u3061\u307e\u3059\u304c\uff0c\u305d\u308c\u306f\u591a\u304f\u306f\u306a\u3044\u306e\u3067\u60d1\u308f\u3055\u308c\u306a\u3044\u3088\u3046\u306b\u6587\u732e\u3092\u8aad\u307e\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<\/ul>\n<h5>\u6587\u732e<\/h5>\n<div>\n<h4>\u30a8\u30c8\u30dd\u30b7\u30c9\u3067\u518d\u767a\u304c\u6291\u3048\u3089\u308c\u305f\u4f8b<\/h4>\n<p>Al-Kharazi K, et al.: Malignant desmoplastic infantile astrocytoma? a case report and review of the literature. Clin Neuropathol 32: 100-106, 2013<\/p>\n<p>\u751f\u5f8c\uff16\u9031\u9593\u3068\u3044\u3046\u65b0\u751f\u5150\u306e\u75c7\u4f8b\u5831\u544a\u3067\u3059\u3002DIA\u3092\u5168\u6458\u51fa\u3057\u305f\u306e\u3067\u3059\u304c\uff0c3\u30f6\u6708\u5f8c\u306b\u518d\u71c3\u3057\u307e\u3057\u305f\u3002\u75c5\u7406\u6240\u898b\u3067\u306f\uff0cPNET-like area\u3068spindle cell component (MIB-1 25%)\u3067\u306e\u6838\u5206\u88c2\u50cf\u304c\u76ee\u7acb\u3063\u3066\u3044\u305f\u3088\u3046\u3067\u3059\u3002VCR\/CBDCA\/TMZ\u306e\u5316\u5b66\u7642\u6cd5\u30922\u30b3\u30fc\u30b9\u884c\u3063\u305f\u306e\u3067\u3059\u304c\u816b\u760d\u306f\u5897\u5927\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\uff0c\u7d4c\u53e3VP-16\uff08\u30a8\u30c8\u30dd\u30b7\u30c9\uff09\u306e\u6295\u4e0e\u3067\u816b\u760d\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\uff19\u30f6\u6708\u9593\u7d4c\u904e\u3057\u305f\u305d\u3046\u3067\u3059\u3002\u300c\u89e3\u8aac\u300d\u305d\u306e\u5f8c\u306e\u7d4c\u904e\u306b\u95a2\u3057\u3066\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u4f8b\u306f\u751f\u5f8c\uff16\u9031\u9593\u3068\u3044\u3046DIA\u306b\u3057\u3066\u3082\u65e9\u3044\u767a\u75c7\u5e74\u9f62\u3067\u3059\u3002\u307e\u305f\u75c5\u7406\u6240\u898b\u3067spindle cell component\u306eMIB-1\u67d3\u8272\u7387\u304c25%\u306b\u3082\u9054\u3057\u3066\u3044\u3066\uff0c\u901a\u5e38\u306eDIA\u3068\u306f\u7570\u306a\u308b\u3082\u306e\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h4>\u521d\u56de\u624b\u8853\u3060\u3051\u3067\u306f\u6cbb\u3089\u306a\u3044\u4f8b\u304c\u610f\u5916\u306b\u591a\u3044?<\/h4>\n<p>Hummel TR, et al.: Clinical heterogeneity of desmoplastic infantile ganglioglioma: a case series and literature review. J Pediatr Hematol Oncol 34: e232-236, 2012<\/p>\n<p>\u904e\u53bb\u306e\u6587\u732e\u3092\u307e\u3068\u3081\u308b\u3068\uff0cDIG\u306e23%\u304c\u751f\u5f8c24\u30f6\u6708\u4ee5\u964d\u306b\u767a\u75c7\u3059\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u521d\u56de\u624b\u8853\u306e\u5f8c\u3067\uff0c\u7d0440\uff05\u3067\u8ffd\u52a0\u306e\u6cbb\u7642\u304c\u5fc5\u7528\u306b\u306a\u3063\u3066\u3044\u305f\u305d\u3046\u3067\uff0c\u518d\u624b\u8853\uff0c\u5316\u5b66\u7642\u6cd5\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306a\u3069\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u300215%\u306e\u4e73\u5150\u304c\uff0c\u9ac4\u819c\u64ad\u7a2e\u3084\u816b\u760d\u306e\u5897\u5927\u3067\u6b7b\u4ea1\u3057\u3066\u3044\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u300c\u89e3\u8aac\u300d\u3053\u308c\u306f\u904e\u53bb\u306e\u6587\u732e\u75c7\u4f8b\u5831\u544a\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002\u6587\u732e\u5831\u544a\u3068\u3044\u3046\u306e\u306f\u7a00\u306a\u4f8b\u3092\u8a18\u8f09\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\uff0c\u5f53\u305f\u308a\u524d\u306e\u3088\u3046\u306b\u521d\u56de\u624b\u8853\u3067\u6cbb\u3063\u3066\u3057\u307e\u3063\u305f\u4f8b\u306e\u5831\u544a\u983b\u5ea6\u306f\u4f4e\u3044\u3082\u306e\u3068\u60f3\u5b9a\u3055\u308c\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0cDIG\/DIA\u304c\u3053\u306e\u69d8\u306b\u60aa\u3044\u7d4c\u904e\u3092\u305f\u3069\u308b\u3068\u306f\u601d\u3048\u307e\u305b\u3093\u3002<\/p>\n<h4>\u60aa\u6027\u5316\u3057\u3066\u81a0\u82bd\u816b\u306b\u306a\u3063\u305f\u4f8b<\/h4>\n<p align=\"left\">Loh JK,et al.: Malignant transformation of a desmoplastic infantile ganglioglioma. Pediatr Neurol 45: 135-137, 2011<br \/>\nPhi JH, et al.: Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report. Childs Nerv Syst 27:2177-2181, 2011<\/p>\n<p align=\"left\">Loh\u306e\u5831\u544a\u3067\u306f\uff0c\uff15\u624d\u306e\u6642\u306bDIG\u306e\u6458\u51fa\u3092\u53d7\u3051\u30663\u5e74\u5f8c\u306b\u518d\u767a\u3057\uff0c\u81a0\u82bd\u816b\u306e\u8a3a\u65ad\u3067\u3057\u305f\u3002\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u3066\u5bdb\u89e3\u3057\uff0c11\u5e74\u9593\u751f\u5b58\u3057\u3066\u3044\u308b\u4f8b\u3092\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002Phi\u306eDIA\u5831\u544a\u4f8b\u306f\uff0c\u751f\u5f8c22\u30f6\u6708\u3067\u624b\u8853\u6458\u51fa\u3092\u53d7\u3051\u3066\uff0c8\u5e74\u5f8c\u306b\u518d\u767a\u3057\u305f\u5c0f\u5150\u4f8b\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u518d\u767a\u6642\u306e\u75c5\u7406\u7d44\u7e54\u306f\u81a0\u82bd\u816b\u3067\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u4ed6\u306b\u3082\u81a0\u82bd\u816b\u3084PNET\u306b\u5909\u5316\u3057\u3066\uff0c\u60aa\u6027\u5316\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u3042\u308a\u307e\u3059\u3002\u3067\u3082\u304d\u308f\u3081\u3066\u307e\u308c\u306a\u4e8b\u4f8b\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u6587\u732e\u4e0a\u3067\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002\u60aa\u6027\u5316\u7387\u306e\u771f\u306e\u5024\u306f\u4e0d\u660e\u3067\u3059\u3002<\/p>\n<h4 align=\"left\">\u4e73\u5e7c\u5150\u4ee5\u5916\u306e\u4f8b\u3082\u542b\u3081\u305fdesmoplastic ganglioglioma\u3068\u3044\u3046\u6982\u5ff5<\/h4>\n<p align=\"left\">Desmoplastic infantile and non-infantile ganglioglioma. Review of the literature. Neurosurg Rev 34: 151-158, 2010<\/p>\n<p align=\"left\">desmoplastic ganglioglioma\u306b\u306f\uff0cinfantile type\u3068non-infantile type\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u5074\u982d\u8449\u3068\u524d\u982d\u8449\u306e\u8868\u9762\u306b\u597d\u767a\u3057\uff0c\u8868\u5728\u6027\u306b\u816b\u760d\u7d50\u7bc0\u304c\u3042\u308a\u5185\u9762\u306b\u306f\u5927\u304d\u306a\u306e\u3046\u80de\u3092\u4f34\u3046\u3082\u306e\u3067\u3059\u30023\u7a2e\u985e\u306e\u7d30\u80de\u8d77\u6e90\u306e\u816b\u760d\u306e\u90e8\u5206\u304c\u6df7\u5728\u3057\u3066\uff0castrocytic, neuronal, and primitive neuroectodermal marker sites\u3068\u8868\u73fe\u3055\u308c\u307e\u3059\u3002\u6587\u732e\u4e0a\u3067\u5831\u544a\u3055\u308c\u305f113\u4f8b\u3067\u306f\uff0cinfantile type\u304c94\u4f8b\u3067\uff0cnoninfantile\u304c19\u4f8b\u3067\u3057\u305f\u3002\u5b8c\u5168\u6458\u51fa\u3059\u308c\u3070\u5f8c\u7642\u6cd5\uff08\u88dc\u52a9\u7642\u6cd5\uff09\u306e\u5fc5\u7528\u304c\u306a\u3044\u3068\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<h4>\u6587\u732e<\/h4>\n<ol>\n<li>Al-Kharazi K, et al.: Malignant desmoplastic infantile astrocytoma? a case report and review of the literature. Clin Neuropathol 32: 100-106, 2013<\/li>\n<li>Duffner PK et al.: Desmoplastic infantile ganglioglioma: an approach to therapy. Neurosurg 34, 583-589, 1994<\/li>\n<li>Desmoplastic infantile and non-infantile ganglioglioma. Review of the literature. Neurosurg Rev 34: 151-158, 2010<\/li>\n<li>Hummel TR, et al.: Clinical heterogeneity of desmoplastic infantile ganglioglioma: a case series and literature review. J Pediatr Hematol Oncol 34: e232-236, 2012<\/li>\n<li>Loh JK,et al.: Malignant transformation of a desmoplastic infantile ganglioglioma. Pediatr Neurol 45: 135-137, 2011<\/li>\n<li>Phi JH, et al.: Desmoplastic infantile astrocytoma: recurrence with malignant transformation into glioblastoma: a case report. Childs Nerv Syst 27:2177-2181, 2011<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Prakash%20V%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=24768217\">Prakash V<\/a>, et al.: Malignant Transformation of a Desmoplastic Infantile Ganglioglioma in an Infant Carrier of a Nonsynonymous TP53 Mutation. Pediatr Neurol, 2014 [Epub]<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7dda\u7dad\u5f62\u6210\u6027\u4e73\u5150\u661f\u7d30\u80de\u816b\uff0f\u795e\u7d4c\u7bc0\u81a0\u816b\u306b\u3064\u3044\u3066 DIA\/DIG desmoplastic infantile astrocytoma DIA\/ ganglioglioma DIG \u4e73\u5e7c\u5150\u306b\u3067\u304d\u308b\u3068\u3066\u3082\u3081\u305a\u3089\u3057\u3044\u826f\u6027\u816b\u760d\u3067\u3059  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-166","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=166"}],"version-history":[{"count":40,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/166\/revisions"}],"predecessor-version":[{"id":14449,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/166\/revisions\/14449"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}