{"id":160,"date":"2012-04-19T02:03:02","date_gmt":"2012-04-18T17:03:02","guid":{"rendered":"\/sawamura\/wp\/?p=160"},"modified":"2025-09-09T18:34:58","modified_gmt":"2025-09-09T09:34:58","slug":"brainstemglioma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/brainstemglioma\/","title":{"rendered":"\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b DIPG\uff08\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\uff0c\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\uff0c\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\uff09"},"content":{"rendered":"<h5>\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u306e\u306f\u6b63\u78ba\u306a\u8a3a\u65ad\u540d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/h5>\n<div class=\"setumei\">\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u3055\u307e\u3056\u307e\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059<\/strong><\/span><\/li>\n<li>\u8133\u5e79\u90e8\u306b\u306f\u3069\u3093\u306a<span style=\"color: #000080;\"><strong><a style=\"color: #000080;\" title=\"\u30b0\u30ea\u30aa\u30fc\u30de glioma \u795e\u7d4c\u81a0\u816b\" href=\"\/sawamura\/braintumors\/glioma\/sum\/\">\u30b0\u30ea\u30aa\u30fc\u30de<\/a><\/strong><\/span>\u3067\u3082\u3067\u304d\u307e\u3059\u3057\uff0c\u305d\u308c\u305e\u308c\u3067\u6cbb\u7642\u65b9\u6cd5\u304c\u7570\u306a\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u4e2d\u306e\u3044\u3063\u305f\u3044\u4f55\u3092\u4e88\u60f3\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u805e\u3044\u3066\u304b\u3089\u6cbb\u7642<\/strong><\/span>\u3092\u53d7\u3051\u3066\u4e0b\u3055\u3044<\/li>\n<li>\u3082\u3063\u3068\u3082\u6709\u540d\u306a\u306e\u306f\uff0c<strong><span style=\"color: #ff0000;\">\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b DIPG\u00a0<\/span><\/strong>\u3067\u4e0b\u306e\u65b9\u306b\u8a73\u3057\u304f\u66f8\u3044\u3066\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3082\u4ed6\u306b\uff0c<a href=\"\/sawamura\/glioma\/pilo\/\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/a>\uff0c<a href=\"\/sawamura\/glioma\/gangliocyto\/\">\u795e\u7d4c\u7bc0\u7d30\u80de\u816b\uff0c\u795e\u7d4c\u7bc0\u81a0\u816b\uff0c\u9000\u5f62\u6210\u6027\u795e\u7d4c\u7bc0\u81a0\u816b<\/a>\uff0c<a href=\"\/sawamura\/pediattumor\/ependy\/\">\u4e0a\u8863\u816b\uff0c\u9000\u5f62\u6210\u6027\u4e0a\u8863\u816b\uff0c<\/a><a href=\"\/sawamura\/glioma\/astrocytictumor\/\">\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff0c\u81a0\u82bd\u816b<\/a>\uff0c<a href=\"\/sawamura\/glioma\/olig\/\">\u4e4f\u7a81\u8d77\u81a0\u816b\uff0c\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u816b<\/a>\uff0c<a title=\"AT\/RT\" href=\"\/sawamura\/pediattumor\/atrt\/\">AT\/RT<\/a>\uff0c<a title=\"PNET \u30d4\u30fc\u30cd\u30c3\u30c8\" href=\"\/sawamura\/pediattumor\/pnet\/\">PNET<\/a>\uff0c\u4e0a\u8863\u82bd\u816b\uff0c\u3073\u307e\u3093\u6027\u81a0\u8089\u816b\u306a\u3069\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u3067\u304d\u307e\u3059<\/li>\n<li>\u983b\u5ea6\u3067\u9806\u756a\u3092\u3064\u3051\u308b\u3068\uff0c\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u306e\u9806\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u3053\u308c\u3089\u306e\u816b\u760d\u306e\u8a3a\u65ad\u3084\u6cbb\u7642\u65b9\u6cd5\u306f\u305d\u308c\u305e\u308c\u5225\u30da\u30fc\u30b8\u306b\u66f8\u3044\u3066\u3042\u308a\u307e\u3059<\/li>\n<li>\u826f\u6027\u3067\u3059\u304c\u6cbb\u7642\u9078\u629e\u304c\u96e3\u3057\u3044\u3082\u306e\u306b\uff0c<a title=\"\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3068\u6bdb\u69d8\u7c98\u6db2\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/pediattumor\/pilos\/\">\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b<\/a>\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><a title=\"\u795e\u7d4c\u7bc0\u7d30\u80de\u816b\uff0c\u795e\u7d4c\u7bc0\u81a0\u816b\" href=\"\/sawamura\/braintumors\/glioma\/gangliocyto\/\">\u795e\u7d4c\u7bc0\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c91<\/a>\uff0c\u904e\u8aa4\u816b\uff08\u5f62\u6210\u7570\u5e38\uff0c\u7570\u6240\u6027\u7070\u767d\u8cea\uff09\u306a\u3069\u6cbb\u7642\u3057\u306a\u304f\u3066\u3082\u3088\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059<\/li>\n<li><a title=\"\u4e0a\u8863\u816b\" href=\"\/sawamura\/pediattumor\/ependy\/\">\u4e0a\u8863\u816b<\/a>\u3084<a title=\"\u9ac4\u82bd\u816b\" href=\"\/sawamura\/pediattumor\/medullo\/\">\u9ac4\u82bd\u816b<\/a>\u3084<a title=\"\u8108\u7d61\u53e2\u4e73\u982d\u816b\" href=\"\/sawamura\/pediattumor\/choroidplexus\/\">\u8108\u7d61\u53e2\u4e73\u982d\u816b<\/a>\u306f\uff0c\u8133\u5e79\u90e8\u306b\u7652\u7740\u3057\u307e\u3059\u304c\u8133\u5e79\u816b\u760d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u5c0f\u5150\u306e\u9ad8\u5ea6\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3057\u3066\uff0c\u80ce\u5150\u6027\u816b\u760d\u306e<a title=\"AT\/RT\" href=\"\/sawamura\/pediattumor\/atrt\/\">AT\/RT<\/a>\uff0c<a title=\"PNET \u30d4\u30fc\u30cd\u30c3\u30c8\" href=\"\/sawamura\/pediattumor\/pnet\/\">PNET<\/a>\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><a href=\"\/sawamura\/glioma\/tectal-glioma\/\">\u4e2d\u8133\u8996\u84cb\u30b0\u30ea\u30aa\u30fc\u30de<\/a>\u3068\u3044\u3046\u306e\u306f\u975e\u5e38\u306b\u7279\u6b8a\u306a\u30bf\u30a4\u30d7\u306e\u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059<\/li>\n<li>\u601d\u6625\u671f\u4ee5\u964d\u3084\u6210\u4eba\u306e\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306f\uff0c\u4ee5\u4e0b\u306b\u66f8\u3044\u3066\u3042\u308b\u3053\u3068\u306f\u5f53\u3066\u306f\u307e\u308a\u307e\u305b\u3093\u306e\u3067\u8aad\u307e\u306a\u3044\u3067\u4e0b\u3055\u3044<\/li>\n<\/ul>\n<h5><span style=\"color: #ff0000;\">2025\u5e748\u67086\u65e5\u7c73\u56fd\u3067 \u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u5bfe\u3057\u3066dordaviprone (ONC201) \u306e\u4f7f\u7528\u304c\u8a8d\u53ef\u3055\u308c\u307e\u3057\u305f<br \/>\n<span style=\"color: #000080;\">\u5546\u54c1\u540d \u30e2\u30c7\u30a4\u30bd\u00a0Modeyso<\/span><br \/>\n<\/span><br \/>\n1\u6b73\u4ee5\u4e0a\u3067H3K27\u5909\u7570\u304c\u3042\u308a\uff0c\u518d\u767a\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u306e\u307f\u3067\u3059\uff0c\u9031\u306b\u4e00\u56de\uff0c\uff11\u30ab\u30d7\u30bb\u30eb\u3092\u98f2\u307f\u307e\u3059<\/p>\n<p><span style=\"color: #ff0000;\">DIPG\u306e\u60a3\u8005\u3055\u3093\u306f\u9664\u5916\u3055\u308c\u3066\u3044\u307e\u3059<\/span><\/h5>\n<hr \/>\n<h1><span style=\"color: #000080;\">\u3073\u307e\u3093\u6027\u5185\u5728\u6027\u6a4b\u81a0\u816b (\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de)<br \/>\n<\/span><strong><span style=\"color: #000080;\">diffuse intrinsic pontine glioma, DIPG\u00a0<\/span><\/strong><\/h1>\n<h1><span style=\"color: #000080;\">\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<br \/>\ndiffuse midline glioma H3K27M mutant<\/span><\/h1>\n<ul>\n<li>\u540c\u3058\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u3067\u751f\u3058\u308b\u306e\u3067\uff0c2016\u5e74\u304b\u3089<span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/diffusemidlineglioma\/\"><strong>\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de diffuse midline glima DMG<\/strong><\/a><\/span>\u3068\u547c\u3076\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f<\/li>\n<li>\u3067\u3082DIPG\u3068DMG\u306f\u305a\u3044\u3076\u3093\u9055\u3063\u305f\u81e8\u5e8a\u50cf\u3092\u793a\u3057\u307e\u3059<\/li>\n<li>\u8133\u5e79\u90e8\u5185\u90e8\u306b\u767a\u751f\u3059\u308b<strong><span style=\"color: #ff0000;\">\u4e88\u5f8c\u4e0d\u826f\u306e\u5c0f\u5150\u816b\u760d<\/span><\/strong>\u3067\u3059<\/li>\n<li>\u5c0f\u5150\u8133\u816b\u760d\u306e10%\u304f\u3089\u3044\u3067\u3059<\/li>\n<li>\u5c0f\u5150\u3067\u306f<strong><span style=\"color: #ff0000;\">\uff13\u6b73\u304b\u3089\uff17\u6b73\u304f\u3089\u3044<\/span><\/strong>\u306e\u5e7c\u5150\u306b\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u307e\u308c\u306b\u82e5\u5e74\u6210\u4eba\u306b\u3082\u307f\u3089\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/anatomys\/brainstem.html\">\u8133\u5e79\u90e8<\/a><\/span>\u306f\u8133\u306e\u4e2d\u3067\u3082\u6700\u3082\u91cd\u8981\u306a\u90e8\u4f4d\u3068\u3055\u308c\uff0c\u5927\u8133\u304b\u3089\u306e\u795e\u7d4c\u7dda\u7dad\u304c\u96c6\u4e2d\u3057\u3066\u8d70\u308b\u90e8\u4f4d\u3067\u3059\u3057\uff0c\u547c\u5438\u4e2d\u67a2\u3084\u610f\u8b58\u306e\u4e2d\u67a2\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u8133\u5e79\u90e8\u306f\u4e0a\u306e\u65b9\u304b\u3089\u9806\u306b<a href=\"\/sawamura\/anatomys\/brainstem.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u4e2d\u8133\uff0c\u6a4b\uff0c\u5ef6\u9ac4<\/a>\u3068\u547c\u3070\u308c\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u307b\u3068\u3093\u3069\u306e\u4f8b\u306f\u6a4b pons \u306b\u767a\u751f\u3059\u308b<\/span><\/strong>\u306e\u3067\uff0c\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de pontine glioma \u3068\u3082\u547c\u3070\u308c\u307e\u3059<\/li>\n<li>\u3082\u3057\u4e07\u4e00\uff0c\u751f\u691c\u8853\u304c\u3055\u308c\u305f\u5834\u5408\uff0c<span style=\"color: #000080;\">\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306e\u75c5\u7406\u7d44\u7e54\u306f<a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/astrocytictumor.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u661f\u7d30\u80de\u7cfb\u816b\u760d<\/a><\/span>\u3067\u3059<\/li>\n<li>\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3068\u306f\uff0c<span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/braintumors\/astrocytictumor.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c91\u22124\uff0c\u81a0\u82bd\u816b<\/a><\/span>\u3092\u3044\u3044\u307e\u3059<\/li>\n<li>\u672b\u671f\u306b\u306a\u308b\u3068\u307b\u3068\u3093\u3069\u304c\u81a0\u82bd\u816b\u306e\u75c5\u7406\u6240\u898b\u3092\u5448\u3057\u307e\u3059\uff08\u5256\u691c\u5831\u544a\uff09<\/li>\n<li><span style=\"color: #000080;\"><strong>80%\u304f\u3089\u3044\u306e\u4f8b\u3067histone H3\u306eK27M\u907a\u4f1d\u5b50\u306b\u5909\u7570<\/strong><\/span>\u304c\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n<h5>\u75c7\u72b6<\/h5>\n<ul>\n<li>\u521d\u671f\u75c7\u72b6\u306f\uff0c\u7247\u65b9\u306e\u76ee\u304c\u5185\u5074\u306b\u3088\u308b<span style=\"color: #000080;\"><strong>\u5185\u659c\u8996<\/strong><\/span> \uff08esotropia, \u5916\u8ee2\u795e\u7d4c\u9ebb\u75fa\uff09\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u6b21\u3044\u3067\uff0c<strong><span style=\"color: #000080;\">\u3075\u3089\u3064\u3044\u3066\u6b69\u304f\u306e\u304c\u4e0d\u5b89\u5b9a<\/span><\/strong>\u306b\u306a\u308b\u3053\u3068\uff08\u5931\u8abf\u6027\u6b69\u884c\uff09\u3067\u3059<\/li>\n<li>\uff13\u30f6\u6708\u304f\u3089\u3044\u3067\u3086\u3063\u304f\u308a\u9032\u884c\u3057\u3066\u6c17\u3065\u304b\u308c\u308b\u3082\u306e\u304b\u3089\u3001\uff13\u9031\u9593\u304f\u3089\u3044\u3067\u6025\u6fc0\u306b\u3072\u3069\u3044\u75c7\u72b6\u306b\u306a\u308b\u3082\u306e\u307e\u3067\u3042\u308a\u307e\u3059<\/li>\n<li>\u9006\u306b3\u30f6\u6708\u4ee5\u4e0a\u304b\u304b\u3063\u3066\u3086\u3063\u304f\u308a\u9032\u884c\u3057\u3066\u3044\u308b\u8133\u795e\u7d4c\u9ebb\u75fa\u3084\u5931\u8abf\u75c7\u72b6\u3067\u306f\uff0c\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u4ee5\u5916\u306e\u3082\u306e\u3082\u8003\u3048\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li><span style=\"color: #000080;\"><strong>\u9854\u304c\u3086\u304c\u3080<\/strong><\/span>\uff08\u9854\u9762\u795e\u7d4c\u9ebb\u75fa\uff09\u3084<span style=\"color: #000080;\"><strong>\u773c\u306e\u4f4d\u7f6e\u304c\u304a\u304b\u3057\u3044<\/strong><\/span>\uff08\u773c\u7403\u904b\u52d5\u969c\u5bb3\uff09\u306a\u3069\u306e\u8133\u795e\u7d4c\u75c7\u72b6\u3082\u3067\u307e\u3059\u304c\uff0c\u5c0f\u5150\u306f\u81ea\u5206\u304b\u3089\u75c7\u72b6\u3092\u8a34\u3048\u308b\u3053\u3068\u304c\u5c11\u306a\u3044\u3067\u3059<\/li>\n<li>\u6c34\u982d\u75c7\u306b\u306a\u308b\u3068\uff0c<strong><span style=\"color: #000080;\">\u982d\u75db\u3084\u5614\u5410<\/span><\/strong>\u304c\u3067\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-18366\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-2.png\" alt=\"\" width=\"277\" height=\"282\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-18365\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-1-290x300.png\" alt=\"\" width=\"290\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-1-290x300.png 290w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgli-1.png 349w\" sizes=\"auto, (max-width: 290px) 100vw, 290px\" \/><\/a><\/p>\n<h5>MRI\u753b\u50cf\u8a3a\u65ad<\/h5>\n<ul>\n<li>MRI\u3067\u306f\u8133\u5e79\u90e8\uff08\u3068\u304f\u306b\u6a4b\uff09\u304c\u816b\u308c\u3066\u5927\u304d\u304f\u306a\u308a\u307e\u3059<\/li>\n<li>\u591a\u304f\u306e\u5834\u5408\u306f\u5de6\u53f3\u5bfe\u79f0\u3067\u3059\u304c\uff0c\u975e\u5bfe\u79f0\u306e\u3082\u306e\u3082\u3081\u305a\u3089\u3057\u304f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>MRI\u306eFLAIR\uff08\u30d5\u30ec\u30a2\uff09\u753b\u50cf\u3068\u304bT2\u5f37\u8abf\u753b\u50cf\u3067\uff0c\u767d\u304f\u307c\u30fc\u3063\u3068\u6ef2\u3093\u3060\u3088\u3046\u306b\u6620\u308a\u307e\u3059<\/li>\n<li>\u9ac4\u6db2\u306b\u306e\u3063\u3066\u810a\u9ac4\u306b\u8ee2\u79fb\u3059\u308b\u9ac4\u6db2\u64ad\u7a2e\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><a href=\"\/sawamura\/anatomys\/brainstem.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u8133\u5e79\u90e8\u306e\u6a4b<\/a>\u3068\u3044\u3046\u3068\u3053\u308d\u3092\u4e2d\u5fc3\u306b\u3057\u3066\u767a\u751f\u3057\uff0c\u4e0a\u65b9\u306e\u4e2d\u8133\u3084\u4e0b\u65b9\u306e\u5ef6\u9ac4\u306b\u6d78\u6f64\u3057\u3066\u4f38\u3073\u3066\u3044\u304d\u307e\u3059<\/li>\n<li>\u3053\u306e\u69d8\u306a\u5178\u578b\u7684\u306a\u3082\u306e\u3067\u306f\u624b\u8853\u3092\u3057\u306a\u304f\u3066\u3082MRI\u3067\u78ba\u5b9a\u8a3a\u65ad\u304c\u3064\u304f\u3082\u306e\u3067\u3059\u304b\u3089\uff0c\u75c5\u7406\u907a\u4f1d\u5b50\u8a3a\u65ad\u306e\u305f\u3081\u306e<span style=\"color: #ff0000;\"><strong>\u5b9a\u4f4d\u7684\u751f\u691c\u8853 stereotactic biopsy \u3084\u958b\u982d\u624b\u8853\u306f\u4f55\u306e\u5229\u76ca\u3082\u3042\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li>\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3068\u3044\u3046\u9020\u5f71\u5264\u3092\u9759\u8108\u6ce8\u5c04\u3057\u3066MRI\u3092\u3068\u308b\u3068\u4e00\u90e8\u5206\u3067\u767d\u304f\u5897\u5f37\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u30ea\u30f3\u30b0\u72b6\u306b\u5897\u5f37\u3055\u308c\u308b\u816b\u760d\u306f\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u816b\u760d\u306f\u5927\u304d\u3044\u306e\u3067\u3059\u304c\uff0c\u6c34\u982d\u75c7\u306b\u306a\u3089\u306a\u3044\u306e\u304c\u7279\u5fb4\u3067\u3059\uff08\u6c34\u982d\u75c7\u306f2\u5272\u304f\u3089\u3044\uff09<\/li>\n<li>\u4e0a\u306e\u5199\u771f\u306e\u4f8b\u3067\u306f\uff0c\u75c7\u72b6\u306f\u8efd\u304f\uff0c\u305f\u3044\u3066\u3044\u306e\u5834\u5408\u306f\u3053\u306e\u304f\u3089\u3044\u306e\u5927\u304d\u3055\u306b\u306a\u3063\u3066\u304b\u3089\u767a\u898b\u3055\u308c\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u524d\u65b9\u306e\u4e2d\u5fc3\u306b\u9ed2\u3044\u70b9\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u898b\u3048\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u8133\u5e95\u52d5\u8108\u3067\uff0c\u3053\u306e<span style=\"color: #000080;\"><strong>\u8133\u5e95\u52d5\u8108\u306e\u56f2\u3044\u8fbc\u307f engulfment<\/strong><\/span> \u306f\uff0cDIPG\u306b\u7279\u5fb4\u7684\u306a\u3082\u306e\u3068\u3044\u3048\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u4e00\u90e8\u5206\u3060\u3051\u304c\u8133\u5e79\u90e8\u304b\u3089\u7a81\u51fa\u3057\u3066\u30ad\u30ce\u30b3\u306e\u3088\u3046\u306b\u4f38\u3073\u308b\u6240\u898b <span style=\"color: #000080;\"><strong>exophytic grwoth<\/strong><\/span> \u306f2\u5272\u304f\u3089\u3044\u306b\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>\u816b\u760d\u5185\u90e8\u306b\u5c0f\u3055\u306a\u816b\u760d\u5185\u51fa\u8840\u304c\u751f\u3058\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>MRI\u3067\u306f\uff0cH3-K27M\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306f\u5224\u5225\u3067\u304d\u307e\u305b\u3093<\/li>\n<\/ul>\n<h5>\u6cbb\u7642\uff1a\u653e\u5c04\u7dda\u6cbb\u7642\u3067\u3059<\/h5>\n<ul>\n<li>\u6458\u51fa\u624b\u8853\u306f\u8133\u5e79\u90e8\u306e\u91cd\u5927\u306a\u6a5f\u80fd\u969c\u5bb3\u3092\u751f\u3058\u308b\u306e\u3067\u3067\u304d\u307e\u305b\u3093<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u624b\u8853\u3057\u3066\u3082\u4f55\u306e\u610f\u5473\u3082\u306a\u3044<\/span><\/strong>\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u958b\u982d\u624b\u8853\u3082\u3057\u304f\u306f\u5b9a\u4f4d\u8133\u624b\u8853\u3084\u5185\u8996\u93e1\u624b\u8853\u3067\uff0c\u5c11\u3057\u53d6\u3063\u3066\u75c5\u7406\u8a3a\u65ad\u3092\u3059\u308b\uff08\u751f\u691c\u8853\uff09\u3068\u63d0\u6848\u3055\u308c\u305f\u6642\u306b\u306f\uff0c\u304a\u5b50\u3055\u3093\u306b\u3068\u3063\u3066\u4f55\u306e\u5229\u76ca\u306b\u306a\u308b\u306e\u304b\u306f\u3063\u304d\u308a\u3057\u305f\u7406\u7531\u3092\u805e\u3044\u3066\u4e0b\u3055\u3044<\/li>\n<li>\u624b\u8853\u3067\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u308b\u3068\u8a00\u308f\u308c\u3066\u3082\uff0c<span style=\"color: #000080;\"><strong>H3 KM27<\/strong><strong><span style=\"color: #000080;\">\u907a\u4f1d<\/span>\u5b50\u5909\u7570\u306e\u3042\u308b\u306a\u3057\u304c\u308f\u304b\u3063\u305f\u3068\u3053\u308d\u3067\u6cbb\u305b\u308b\u6cbb\u7642\u6cd5\u306f\u5224\u660e\u3057\u3066\u3044\u307e\u305b\u3093\uff082025\u5e746\u6708\u6642\u70b9\uff09<\/strong><\/span><\/li>\n<li>\u751f\u691c\u8853\u3057\u3066H3 K27\u5909\u7570\u304c\u306a\u304f\u3066\u3082\uff0c\u7d50\u5c40DIPG\u3068\u3057\u3066\u6cbb\u7642\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u7c73\u56fd\u3067\u3082\u7814\u7a76\u4f53\u5236\u304c\u6574\u3063\u305f\u9650\u3089\u308c\u305f\u65bd\u8a2d\u3067\u3057\u304b\u751f\u691c\u8853\u306f\u8a31\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/strong><\/span>\u3057\uff0c\u65e5\u672c\u3067\u884c\u308f\u308c\u308b\u6839\u62e0\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u8ab0\u304c\u3069\u3093\u306a\u624b\u8853\u3092\u3057\u3066\u3082\u624b\u8853\u3067\u306f\u6cbb\u3089\u306a\u3044\u75c5\u6c17\u3067\u3059<\/li>\n<li>\u4e16\u754c\u6a19\u6e96\u6cbb\u7642\u306f<strong><span style=\"color: #ff0000;\">\u653e\u5c04\u7dda\u6cbb\u7642<\/span><\/strong>\u3067\u3059<\/li>\n<li>1\u56de\uff081\u65e5\uff09<strong><span style=\"color: #ff0000;\">1.6\u304b\u30892.0\u30b0\u30ec\u30a4\u3067\uff0c48\u30b0\u30ec\u30a4\u304b\u308954\u30b0\u30ec\u30a4\u306e\u7167\u5c04<\/span><\/strong>\u3092\u3057\u307e\u3059<\/li>\n<li>\u591a\u304f\u306e\u5834\u5408\uff0c<strong><span style=\"color: #ff0000;\">\u653e\u5c04\u7dda\u7167\u5c04\u306b\u3088\u308a\u4e00\u6642\u7684\u306a\u816b\u760d\u306e\u7e2e\u5c0f\u52b9\u679c\u3068\u75c7\u72b6\u306e\u6539\u5584<\/span><\/strong>\u306f\u5f97\u3089\u308c\u307e\u3059<\/li>\n<li>70%\u304f\u3089\u3044\u306e\u304a\u5b50\u3055\u3093\u3067\uff0c\u75c7\u72b6\u304c\u304b\u306a\u308a\u306f\u3063\u304d\u308a\u6539\u5584\u3057\u307e\u3059<\/li>\n<li><strong>T<span style=\"color: #000080;\">2-FLAIR mismatch sign\u306e\u3042\u308b\u3082\u306e\u306b\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u6709\u52b9\u6027\u304c\u9ad8\u3044\u3068\u3055\u308c\u307e\u3059<\/span><\/strong><\/li>\n<li>\u3057\u304b\u3057\uff0c\u9577\u671f\u306e\u6cbb\u7642\u52b9\u679c\u306f\u304d\u308f\u3081\u3066\u4e0d\u826f\u3067\u518d\u5897\u5927\uff08\u518d\u71c3\uff09\u3057\u307e\u3059<\/li>\n<li>\u4e00\u822c\u7684\u306b\u306f48-54\u30b0\u30ec\u30a4\u3068\u3044\u3046\u653e\u5c04\u7dda\u91cf\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u304c\uff0c\u3061\u3087\u3063\u3068\u591a\u3044\u304b\u3082<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u7d30\u304b\u304f\u5206\u3051\u3066\u305f\u304f\u3055\u3093\u306e\u56de\u6570\u3067\u884c\u3046\u591a\u5206\u5272\u7167\u5c04hyperfractionation\u3068\u3044\u3046\u65b9\u6cd5\u3067<span style=\"color: #ff0000;\"><strong>\u5927\u304d\u306a<\/strong><strong>\u7dda\u91cf(70\u30b0\u30ec\u30a4\u304f\u3089\u3044)\u3092\u304b\u3051\u3088\u3046\u3068\u3044\u3046\u8a66\u307f\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u304c\u5229\u70b9\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span>\u3067\u3057\u305f<\/li>\n<li>\u307e\u305f<span style=\"color: #ff0000;\"><strong>1\u65e5\u7dda\u91cf\u30922\u30b0\u30ec\u30a4\u3088\u308a\u591a\u304f\u3059\u308b\u5c0f\u5206\u5272\u7167\u5c04 hypofracitonation\u3082\u751f\u5b58\u671f\u9593\u3092\u77ed\u304f\u3057\u307e\u3059<\/strong><\/span><\/li>\n<\/ul>\n<h5>\u6cbb\u7642\uff1a\u653e\u5c04\u7dda\u4ee5\u5916\u306e\u3082\u306e<\/h5>\n<ul>\n<li>\u8133\u5e79\u90e8\u306e\u816b\u308c\u304c\u5f37\u304f\u306a\u3063\u3066\u75c7\u72b6\u304c\u60aa\u5316\u3057\u3066\u304d\u305f\u3068\u304d\u306b\u306f<span style=\"color: #000080;\"><strong>\u30b9\u30c6\u30ed\u30a4\u30c9\uff08\u30ea\u30f3\u30c7\u30ed\u30f3\u3001\u30c7\u30ab\u30c9\u30ed\u30f3\uff09\u3092\u4f7f\u3046\u3068\u4e00\u6642\u7684\u306b\u75c7\u72b6<\/strong><\/span>\u304c\u6539\u5584\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u5316\u5b66\u7642\u6cd5\u306f\u52b9\u304b\u306a\u3044\u3068\u601d\u3063\u305f\u65b9\u304c\u3044\u3044\u3067\u3059\u3057\uff0c\u5f37\u304f\u304a\u52e7\u3081\u3067\u304d\u308b\u3082\u306e\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li>\u4e16\u754c\u4e2d\u3067\uff0c\u30cb\u30c9\u30e9\u30f3\uff0c\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\uff0c\u30ab\u30eb\u30dc\u30d7\u30e9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff0c\u30a8\u30c8\u30dd\u30b7\u30c9\u3084\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\uff0c\u30b7\u30af\u30ed\u30d5\u30a9\u30b9\u30d5\u30a1\u30df\u30c9\uff0c<a href=\"\/sawamura\/braintumors\/temozolo.html\" target=\"_blank\" rel=\"noopener noreferrer\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/a>\uff0c<a href=\"\/sawamura\/glioma\/avastine\/\">\u30a2\u30d0\u30b9\u30c1\u30f3<\/a>\uff0c\u30cb\u30e2\u30c4\u30ba\u30de\u30d6\uff0c\u30b2\u30d5\u30a3\u30cb\u30c1\u30d6\uff0c\u30bf\u30eb\u30bb\u30d0\u306a\u3069\u304c\u8a66\u3055\u308c\u307e\u3057\u305f\u304c\uff0c\u5168\u3066\u7121\u52b9\u3067\u3057\u305f<\/li>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u6297\u304c\u3093\u5264\uff09\u306f10\u5e74\u4ee5\u4e0a\u524d\u304b\u3089\u8a66\u3055\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u6709\u52b9\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u7814\u7a76\u7d50\u679c\u306f\u3042\u308a\u307e\u305b\u3093\uff0c\u7121\u52b9\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u610f\u898b\u304c\u307b\u3068\u3093\u3069\u3067\u3059<\/li>\n<li>\u9006\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e\u75c7\u72b6\u306e\u60aa\u5316\u3092\u65e9\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u3066\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u3092\u3059\u308b targeted therapy\u3067\u306e\u6cbb\u7642\u6210\u529f\u4f8b\u306f\u3042\u308a\u307e\u305b\u3093\uff082025\u5e74\u6642\u70b9\uff09<\/li>\n<li>K27M\u5909\u7570\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u7d4c\u53e3\u4f4e\u5206\u5b50\u6cbb\u7642\u85ac <span style=\"color: #000080;\"><strong>ONC201<\/strong><\/span> Akt\/ERK inhibitor\u3068\u3044\u3046\u4f4e\u5206\u5b50\u85ac\u5264\u306e\u6cbb\u9a13\u3082\u3044\u307e\u3060\u6709\u52b9\u6027\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<li><span style=\"color: #000080;\"><strong>2025\u5e746\u6708\u6642\u70b9\u3067\uff0c\u4e16\u754c\u3067\u6709\u52b9\u3068\u3055\u308c\u305f\u5185\u79d1\u6cbb\u7642\u85ac\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span>\uff08no medicinal products with regulatory approval.\uff09<\/li>\n<li><span style=\"color: #000080;\"><strong>\u967d\u5b50\u7dda\u6cbb\u7642 proton therapy<\/strong><\/span>\u304c\u5f93\u6765\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3088\u308a\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u3067\u3082\uff0c\u3053\u308c\u304b\u3089\u3082\u591a\u304f\u306e\u65b0\u85ac\u306e\u6cbb\u9a13\u304c\u59cb\u307e\u308b\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n<h5>\u4e88\u5f8c<\/h5>\n<ul>\n<li>\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u5b50\u4f9b\u305f\u3061\u304c\uff11\u5e74\u304f\u3089\u3044\u306e\u3046\u3061\u306b\u6b7b\u4ea1\u3059\u308b\u78ba\u7387\u306f50%\u7a0b\u5ea6\u3067\u3059<\/li>\n<li>\u6cbb\u7642\u3057\u3066\u3082\u304a\u3088\u305d\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c10\u30f6\u6708\u304b\u30891\u5e74\u304f\u3089\u3044\u3067\u3059<\/li>\n<li>2025\u5e74\u6642\u70b9\u3067\uff0c2\u5e74\u751f\u5b58\u5272\u5408\u306f10%\u4ee5\u4e0b\u3067\u3059<\/li>\n<li>\u3067\u3082\uff0c5\u5e74\u751f\u5b58\u3057\u3066\u3044\u308b\u5b50\u3082\u3044\u307e\u3059\uff0c2%\u304f\u3089\u3044\u3067\u3059<\/li>\n<li>2020\u5e74\u306e\u6bb5\u968e\u3067\u306f\u7279\u5225\u306a\u6cbb\u7642\u6cd5\u3068\u3044\u3046\u306e\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3089\uff0c<strong><span style=\"color: #ff0000;\">\u3067\u304d\u308b\u9650\u308a\u81ea\u5b85\u306b\u8fd1\u3044\u3068\u3053\u308d\u3067\u6cbb\u7642\u3092<\/span><\/strong>\u53d7\u3051\u307e\u3057\u3087\u3046<\/li>\n<li>\u3053\u306e\u75c5\u6c17\u306e\u5834\u5408\u306f\u9060\u65b9\u306e\u7d4c\u9a13\u6570\u306e\u591a\u3044\u65bd\u8a2d\u3078\u79fb\u52d5\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3057\u306a\u3044\u65b9\u304c\u3044\u3044\u3067\u3059<\/li>\n<li>\u3073\u307e\u3093\u6027\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u306f\u9055\u3063\u3066\uff0c\u8133\u5e79\u90e8\u306e\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306f\u5316\u5b66\u7642\u6cd5\u3067\u5c0f\u3055\u304f\u306a\u308a\u307e\u3059\u3057\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u6709\u52b9\u306a\u3053\u3068\u3082\u591a\u3044\u3067\u3059<\/li>\n<li>\u5c0f\u5150\u3068\u7570\u306a\u308a\u6210\u4eba\u306e\u8133\u5e79\u90e8\u306e\u661f\u7d30\u80de\u816b\u3067\u306f\uff0c\u9577\u671f\u751f\u5b58\u4f8b\u3082\u3042\u308a\u307e\u3059\uff0c\u75c5\u7406\u8a3a\u65ad\u306f\u540c\u3058\u3067\u3082\u751f\u7269\u5b66\u7684\u306b\u306f\u7570\u306a\u3063\u305f\u7279\u6027\u3092\u6301\u3064\u3082\u306e\u3067\u3059<\/li>\n<li><a title=\"NF-1\u306b\u5408\u4f75\u3059\u308b\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\" href=\"\/sawamura\/braintumors\/glioma\/nfibrainstem\/\">\u795e\u7d4c\u7dda\u7dad\u816b\u75c7\u306e\uff11\u578b(NF-1)\u306e\u60a3\u5150\u306b\u3067\u304d\u308b\u8133\u5e79\u90e8\u81a0\u816b<\/a>\u306f\u5927\u304d\u304f\u306a\u3089\u306a\u3044\u3057\uff0c\u5927\u304d\u304f\u306a\u3063\u3066\u3082\u6cbb\u7642\u3092\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u306e\u3067\u6c17\u3092\u3064\u3051\u3066\u4e0b\u3055\u3044<\/li>\n<li>NF-1\u306e\u60a3\u8005\u3055\u3093\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u5b89\u6613\u306b\u53d7\u3051\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/li>\n<li>\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u3084<a title=\"NF-1\u306b\u5408\u4f75\u3059\u308b\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\" href=\"\/sawamura\/braintumors\/glioma\/nfibrainstem\/\">NF-1\u306b\u5408\u4f75\u3059\u308b\u8133\u5e79\u90e8\u81a0\u816b<\/a>\u3068\u306e\u9451\u5225\u8a3a\u65ad\u306f\u614e\u91cd\u306b\u3057\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u3087\u3046<\/li>\n<\/ul>\n<h5><a href=\"https:\/\/jrct.niph.go.jp\/latest-detail\/jRCT1030240186\">\u3073\u307e\u3093\u6027\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de (DIPG) \u306e\u591a\u65bd\u8a2d\u5171\u540c\u524d\u65b9\u8996\u7684\u89b3\u5bdf\u7814\u7a76<\/a><br \/>\nhttps:\/\/jrct.niph.go.jp\/latest-detail\/jRCT1030240186<\/h5>\n<ul>\n<li>2024\u5e74\u306b\u57fc\u7389\u533b\u5927\u306e\u9234\u6728\u667a\u6210\u5148\u751f\u304c\u4e2d\u5fc3\u3068\u306a\u3063\u3066\u958b\u59cb\u3055\u308c\u305f\u65e5\u672c\u3067\u306e\u5168\u56fd\u5171\u540c\u81e8\u5e8a\u7814\u7a76\u3067\u3059<\/li>\n<li>\u76ee\u7684\u306f\uff0cDIPG\u306b\u5bfe\u3059\u308b\u7de9\u548c\u30b1\u30a2\u8a3a\u7642\u306e\u5b9f\u614b\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u533b\u7642\u73fe\u5834\u306e\u6307\u91dd\u3068\u306a\u308b\u30ac\u30a4\u30c9\u3092\u4f5c\u6210\u3059\u308b\u3053\u3068\u3067\u3059<\/li>\n<li>\u767b\u9332\u3059\u308b\u65bd\u8a2d\u3067\u306f\u304d\u3081\u7d30\u304b\u306a\u8a3a\u7642\u304c\u63d0\u4f9b\u3055\u308c\u307e\u3059\u3057\uff0c\u652f\u6301\u7de9\u548c\u306b\u3082\u6ce8\u529b\u3057\u3066\u3044\u307e\u3059<\/li>\n<li>\u4f55\u304b\u3042\u308a\u307e\u3057\u305f\u3089\uff0c\u9234\u6728\u5148\u751f\u307e\u3067 (<a href=\"mailto:tmsuzuki@saitama-med.ac.jp\">tmsuzuki@saitama-med.ac.jp<\/a>) \u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044<\/li>\n<li>\u60a3\u8005\u3055\u3093\u304b\u3089\u306e\u30e1\u30fc\u30eb\u3067\u3082\u3044\u3044\u3067\u3059<\/li>\n<\/ul>\n<\/div>\n<div class=\"setumei\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-22719\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/solaillust2-2-225x300.jpg\" alt=\"\" width=\"225\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/solaillust2-2-225x300.jpg 225w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/solaillust2-2-450x600.jpg 450w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/solaillust2-2-768x1024.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/solaillust2-2.jpg 1108w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/><\/p>\n<h4 class=\"setumei\">\u3073\u307e\u3093\u6027\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de<span style=\"color: #ff0000;\">\u3067\u306f\u306a\u3044\u304b\u3082<\/span>\u3057\u308c\u306a\u3044\u6642\u3068\u3044\u3046\u306e\u306f<\/h4>\n<ul>\n<li><strong><span style=\"color: #000080;\">\u4f55\u304b\u5178\u578b\u7684\u306a\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u9055\u3046\u6642\u306b\u306f\uff0c\u5b9a\u4f4d\u8133\u624b\u8853\u3042\u308b\u3044\u306f\u958b\u982d\u624b\u8853\u306b\u3088\u308b\u751f\u691c\u8853\u3067\u306e\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u304c\u5fc5\u8981\u306a\u3068\u304d\u3082\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/span><\/strong>\uff08\u3067\u3082\u7d50\u5c40\uff0c\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3057\u304b\u306a\u3044\u306e\u3067\u5229\u76ca\u304c\u306a\u3044\u304b\u3082\uff09<\/li>\n<li>\u75c7\u72b6\u304c\u51fa\u3066\u304b\u3089\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u308b\u307e\u3067\uff16\u30f6\u6708\u4ee5\u4e0a\u7d4c\u904e\u3057\u3066\u3044\u308b\u3068\u304d\u306f\uff0c\u4f55\u304b\u304c\u3061\u304c\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u601d\u6625\u671f\u4ee5\u964d\u306e\u3082\u306e\u3067\u306f\u9577\u671f\u751f\u5b58\u304c\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u5e74\u9f62\u304c\u9ad8\u3044\u5834\u5408\u306f\u9055\u3063\u305f\u6cbb\u7642\u3068\u4e88\u5f8c\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u9006\u306b\uff0c\uff13\u6b73\u672a\u6e80\u3067\u306f\u307e\u308c\u306b\u9577\u671f\u751f\u5b58\u4f8b\u304c\u3042\u308a\u307e\u3059\uff08\u3057\u304b\u3057\u8aa4\u8a3a\uff0c\u751f\u691c\u304c\u306a\u3055\u308c\u306a\u3044\u306e\u3067\u75c5\u7406\u7d44\u7e54\u304c\u9055\u3046\u3068\u3044\u3046\u610f\u898b\u3082\u3042\u308a\u307e\u3059\uff09<\/li>\n<li>\u753b\u50cf\u6240\u898b\u304c\u5178\u578b\u7684\u3067\u306f\u306a\u3044\u6642\uff08\u3067\u3082\u3053\u308c\u306f\u533b\u5e2b\u306e\u753b\u50cf\u8a3a\u65ad\u80fd\u529b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\uff09<\/li>\n<li>MRI\u3067\u5883\u754c\u304c\u6975\u3081\u3066\u660e\u77ad\u3067\uff0c\u3073\u307e\u3093\u6027\u306b\u898b\u3048\u306a\u3044\u6642\u3067\uff0cT2\/FLAIR\u3067\u5747\u4e00\u306b\u9ad8\u4fe1\u53f7\u306b\u306a\u308b\u6642<\/li>\n<li>\u816b\u760d\u5168\u4f53\uff08\u4e00\u90e8\u3067\u306f\u306a\u304f\uff09\u304c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3067\u5747\u4e00\u306b\u5897\u5f37\u3055\u308c\u308b\u6642<\/li>\n<li>\u816b\u760d\u306e\u4e3b\u4f53\u304c\u5ef6\u9ac4\u304b\u4e2d\u8133\u306b\u3042\u308b\u3082\u306e<\/li>\n<li>\u816b\u760d\u304c\u6a4b\u5185\u90e8\u304b\u3089\u767a\u751f\u3057\u3066\u3044\u3066\u3082\uff0c\u307b\u3068\u3093\u3069\u5927\u90e8\u5206\uff08\u4e00\u90e8\u5206\u3067\u306f\u306a\u3044\uff09\u304c\u6a4b\u306e\u5916\u5074\u306b\u7a81\u51fa\u3057\u3066\u3044\u308b\u6642<\/li>\n<li>\u3067\u306f\u4f55\u304c\u8003\u3048\u3089\u308c\u308b\u304b\u3068\u3044\u3046\u3068\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff0c\u795e\u7d4c\u7bc0\u81a0\u816b\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c91\u304b3\uff0c\u80ce\u5150\u6027\u816b\u760d\uff0cPNET\uff0cAT\/RT\uff0c\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c91-4 \u306a\u3069\u306a\u3069\u3067\u3059<\/li>\n<li>\u3053\u308c\u3089\u306e\u816b\u760d\u3067\u306f\u9577\u671f\u751f\u5b58\u4f8b\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3082\uff0c\u3057\u304b\u3057\uff0c<span style=\"color: #000080;\"><strong>\u5b89\u6613\u306b\u751f\u691c\u8853\u3092\u53d7\u3051\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/strong><\/span>\uff0c\u753b\u50cf\u3067\u9451\u5225\u3067\u304d\u308b\u3053\u3068\u304c\u591a\u3044\u304b\u3089\u3067\u3059<\/li>\n<\/ul>\n<\/div>\n<div class=\"setumei\">\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic1.jpg\" rel=\"attachment wp-att-8753\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8753 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic1-294x300.jpg\" alt=\"brainstemgliomaic1\" width=\"294\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic1-294x300.jpg 294w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic1-550x562.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic1.jpg 567w\" sizes=\"auto, (max-width: 294px) 100vw, 294px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2.jpg\" rel=\"attachment wp-att-8754\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8754 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2-300x297.jpg\" alt=\"brainstemgliomaic2\" width=\"300\" height=\"297\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2-300x297.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2-550x544.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/brainstemgliomaic2.jpg 567w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u3053\u306e\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u6a4b\u304b\u3089\u5c0f\u8133\u811a\u306b\u6d78\u6f64\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u306e\u9032\u884c\u4f8b\u306b\u3082\u307f\u3048\u307e\u3059\u304c\uff0c\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u306e\u3055\u308c\u65b9\u304c\u4e2d\u5fc3\u90e8\u3067\u5f37\u3059\u304e\u3066\u975e\u5b9a\u578b\u7684\u3067\u3059\u3002\u3053\u308c\u3092\u751f\u691c\u8853\u3057\u3066\u75c5\u7406\u78ba\u5b9a\u8a3a\u65ad\u3092\u3059\u308c\u3070\uff0c\u80ce\u5150\u6027\u816b\u760d\u3084AP\/RT\u3068\u3044\u3046\u8a3a\u65ad\u304c\u3064\u304f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\uff0c\u3067\u304d\u308b\u3053\u3068\u306f\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u4e3b\u4f53\u306e\u6cbb\u7642\u3067\u306a\u3093\u3089\u304b\u306e\u5316\u5b66\u7642\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u304f\u3089\u3044\u3067\u3059\u3002\u30ea\u30b9\u30af\u306e\u5927\u304d\u3044\u75c5\u7406\u8a3a\u65ad\u3067\u6642\u3092\u5931\u3046\u3088\u308a\u65e9\u304f\u6cbb\u7642\u3092\u958b\u59cb\u3057\u305f\u307b\u3046\u304c\u3088\u3044\u3068\u601d\u308f\u308c\u308b\u7d4c\u904e\u3068\u753b\u50cf\u3067\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-8633 size-medium\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/pontinegliomalat-295x300.jpg\" alt=\"pontinegliomalat\" width=\"295\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/pontinegliomalat-295x300.jpg 295w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/pontinegliomalat-550x560.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/pontinegliomalat.jpg 567w\" sizes=\"auto, (max-width: 295px) 100vw, 295px\" \/><br \/>\n\u3053\u306e\u8133\u5e79\u90e8\u306e\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306f\u5c0f\u5150\u306b\u767a\u751f\u3057\u305f\u3082\u306e\u3067\u3059\u3002lateratity\u304c\u5f37\u3044\u3068\u8868\u73fe\u3059\u308b\u306e\u3067\u3059\u304c\uff0c\u5de6\u5074\u306b\u504f\u3063\u3066\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u901a\u5e38\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u3067\u306f\u7406\u89e3\u304c\u3067\u304d\u306a\u3044\u753b\u50cf\u3067\u3059\u304b\u3089\uff0c\u751f\u691c\u8853\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3067\u3082\u75c5\u7406\u78ba\u5b9a\u8a3a\u65ad\u304c\u3064\u3044\u305f\u304b\u3089\u3068\u3044\u3063\u3066\uff0c\u6cbb\u7642\u3068\u3057\u3066\u3067\u304d\u308b\u3053\u3068\u306f50\u30b0\u30ec\u30a4\u304f\u3089\u3044\u307e\u3067\u306e\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u3060\u3051\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<h5><span style=\"color: #000080;\">\u5c0f\u5150\u3073\u307e\u3093\u6027\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u75c5\u6c17\u306e\u9032\u884c<\/span><\/h5>\n<ul>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3068\u5927\u90e8\u5206\u306e\u60a3\u5150\u3067\u75c5\u6c17\u306e\u9032\u884c\u304c\u3068\u307e\u3063\u3066\u75c7\u72b6\u304c\u826f\u304f\u306a\u308a\u307e\u3059<\/li>\n<li>\u3053\u306e\u75c7\u72b6\u306e\u6539\u5584\u306f30\u30b0\u30ec\u30a4\u304f\u3089\u3044\u306e\u653e\u5c04\u7dda\u304c\u5165\u3063\u305f\u3068\u3053\u308d\u304f\u3089\u3044\u3067\u751f\u3058\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u7d42\u4e86\u3057\u3066\u304b\u3089\uff0c\u307e\u305f\u75c5\u6c17\u304c\u60aa\u5316\uff08\u518d\u71c3\uff09\u3057\u3066\u3057\u307e\u3046\u307e\u3067\u306e\u671f\u9593 (PFS, TTP, EFS) \u306f\uff0c\uff15\u30f6\u6708\u304b\u3089\uff19\u30f6\u6708\u304f\u3089\u3044\u304c\u76ee\u5b89\u3067\u3059<\/li>\n<li>\u751f\u547d\u3092\u5931\u3063\u3066\u3057\u307e\u3046\u307e\u3067\u306e\u671f\u9593(OS)\u306f\uff0c\u4e2d\u592e\u5024\u3067\uff17\u30f6\u6708\u3068\u308216\u30f6\u6708\u3068\u3082\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u7d42\u4e86\u3057\u3066\u304b\u3089\u6570\u30f6\u6708\u306e\u671f\u9593\u3057\u304b\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u6642\u9593\u3092\u5927\u5207\u306b\u3057\u3088\u3046\u3068\u3044\u3046\u306e\u304c\u5927\u90e8\u5206\u306e\u533b\u5e2b\u306e\u8003\u3048\u65b9\u3067\u3059<\/li>\n<li>\u5165\u9662\u6a5f\u95a2\u304c\u9577\u3044\u5316\u5b66\u7642\u6cd5\u3092\u3059\u308b\u306e\u306f\u5927\u5207\u306a\u6642\u9593\u3092\u5931\u3046\u3060\u3051\u306e\u7d50\u679c\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u751f\u5b58\u671f\u9593\u304c\u6bd4\u8f03\u7684\u9577\u3044\u306e\u306f\uff0c\uff13\u6b73\u672a\u6e80\u306e\u5c0f\u5150\uff0c\u75c5\u6c17\u304c\u767a\u898b\u3055\u308c\u308b\u307e\u3067\u306e\u75c7\u72b6\u306e\u7d99\u7d9a\u671f\u9593\u304c\u9577\u304b\u3063\u305f\u4f8b\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n<h5>\u7a76\u6975\u306b\u96e3\u3057\u3044\u554f\u984c<\/h5>\n<p>\u3068\u3066\u3082\u96e3\u3057\u3044\u3053\u3068\u306a\u306e\u3067\u3059\u304c\uff0c\u300c\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u300d\u3068\u300c\u8133\u5e79\u5185\u90e8\u304b\u3089\u767a\u751f\u3057\u305f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u300d\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306f\u540c\u3058\u3067\u3082\uff0c\u6cbb\u7642\u65b9\u6cd5\u3068\u4e88\u5f8c\u304c\u9055\u3044\u307e\u3059\uff0c\u307e\u305f\u753b\u50cf\u6240\u898b\u304c\u3061\u3087\u3063\u3068\u9055\u3044\u307e\u3059\uff0c\u3053\u308c\u3092\u5c0f\u5150\u79d1\u306e\u5148\u751f\u304c\u7406\u89e3\u3057\u3066\u4e0b\u3055\u308b\u3053\u3068\u3092\u671b\u307f\u307e\u3059<\/p>\n<h1><a href=\"http:\/\/glioma-net.com\">\u5c0f\u5150\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u4f1a\u3068\u3044\u3046\u60a3\u8005\u3055\u3093\u306e\u96c6\u307e\u308a\u304c\u3042\u308a\u307e\u3059<br \/>\n\uff08\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/h1>\n<\/div>\n<h5>\u751f\u691c\u8853\u306f\u3057\u306a\u3044\uff1a\u53e4\u3044\u3051\u308c\u3069\u3068\u3066\u3082\u5927\u5207\u306a\u6587\u732e<\/h5>\n<h5>Children&#8217;s Cancer Group Protocol CCG-9882\u306e\u7d50\u679c\u304b\u3089Albright\u304c\u6b21\u306e\u3088\u3046\u306b\u6307\u6458\u3057\u307e\u3057\u305f<br \/>\n<strong>\u201d\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u751f\u691c\u8853\u306f\u8133\u5916\u79d1\u306e\u6b74\u53f2\u306e\u4e2d\u306b\u846c\u3089\u308c\u308b\u3079\u304d\u3067\u3042\u308b&#8221;<\/strong><br \/>\n<strong style=\"background-color: #f4f9ff;\">Routine biospy should be relegated to neurosurgical history.<\/strong><\/h5>\n<div class=\"setumei\">\n<p>2018\u5e74\u6642\u70b9\u3067\u3082\uff0cDIPG\u304c\u7591\u308f\u308c\u3066\u751f\u691c\u8853\u3092\u53d7\u3051\u3066\u3082\u3044\u3044\u5834\u5408\u3068\u3044\u3046\u306e\u306f\uff0c\u65b0\u305f\u306a\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u306e\u6cbb\u9a13\u306b\u304a\u5b50\u3055\u3093\u304c\u767b\u9332\u3057\u3066\u53c2\u52a0\u3067\u304d\u308b\u7279\u6b8a\u306a\u5834\u5408\u306e\u307f\u3067\u3059\u3002\u65e5\u672c\u3067\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h5>\u5927\u5f8c\u982d\u5b54\u6e1b\u5727\u8853\u30fb\u5f8c\u982d\u4e0b\u6e1b\u5727\u8853\u306f\u3057\u306a\u3044<\/h5>\n<ul>\n<li>\u5c0f\u8133\u3068\u8133\u5e79\u90e8\u306e\u5727\u8feb\u3092\u3068\u308b\u305f\u3081\u306b\uff0c\u5f8c\u982d\u90e8\u306e\u9aa8\u3092\u306f\u305a\u3059\u624b\u8853\u3092\u52e7\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3053\u308c\u306f\u4e16\u754c\u7684\u306b\u898b\u308c\u3070<span style=\"color: #000080;\"><strong>\u304b\u306a\u308a\u975e\u5e38\u8b58\u306a\u5916\u79d1\u6cbb\u7642<\/strong><\/span>\u3067\u3059\u304b\u3089\uff0c\u53d7\u3051\u306a\u3044\u307b\u3046\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n<p>\u77ed\u3044\u4e88\u5f8c\u306b\u5bfe\u3057\u3066\u624b\u8853\u4fb5\u8972\u304c\u5927\u304d\u304f\uff0c\u671f\u5f85\u3055\u308c\u308b\u52b9\u679c\u304c\u5c11\u306a\u3059\u304e\u308b\u306e\u3067\u884c\u308f\u308c\u307e\u305b\u3093<\/p>\n<h5>\u7c73\u56fd\u306e\u30c8\u30e9\u30a4\u30a2\u30eb\u306e\u771f\u4f3c\u306f\u3067\u304d\u307e\u305b\u3093<\/h5>\n<p class=\"solo_record\"><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01182350\">NIH\u306e\u81e8\u5e8a\u7814\u7a76\u306e\u5e83\u5831<\/a>\u306b\uff0cMolecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG)\u3068\u3044\u3046\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u304c\u3042\u308a\u307e\u3057\u305f\u3002Dr.\u00a0Kieran\u304c\u63d0\u5531\u3057\u305f\u3082\u306e\u3067\uff0c\u751f\u691c\u8853\u3067\u5224\u660e\u3057\u305f\u907a\u4f1d\u5b50\u60c5\u5831\uff08MGMT\u3068EGFR\u306e\u5909\u7570\uff09\u306b\u3088\u3063\u3066\uff0c\u30a2\u30d0\u30b9\u30c1\u30f3\uff0c\u30bf\u30eb\u30bb\u30d0\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u4f7f\u3044\u5206\u3051\u308b\u3068\u3044\u3046\u8a08\u753b\u3067\u3059\u30022011\u5e749\u6708\u306b\u958b\u59cb\u3055\u308c\uff0c\u767b\u9332\u306f\u7de0\u3081\u5207\u3089\u308c\u307e\u3057\u305f\u304c\u7d50\u679c\u306f\u516c\u8868\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u3063\u304b\u308a\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u6574\u3063\u3066\u3044\u306a\u3044\u65e5\u672c\u3067\u306f\uff0c\u502b\u7406\u7684\u306a\u89b3\u70b9\u304b\u3089\uff0c<strong><span style=\"color: #000080;\">\u3053\u306e\u3088\u3046\u306a\u5b9f\u9a13\u7684\u6cbb\u7642\u3092\u65e5\u672c\u3067\u307e\u306d\u3066\u884c\u3046\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/span><\/strong><\/p>\n<h5><span style=\"color: #ff0000;\">ONC201<\/span>(OP-10) \u7c73\u56fd\u3067\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u304c\u59cb\u307e\u308a\u307e\u3057\u305f<\/h5>\n<p>2022\u5e7412\u6708\uff0cONC201\u30921\u9031\u9593\u3054\u3068\u306b1\u56de\u7d4c\u53e3\u6442\u53d6\u30011\u30b3\u30fc\u30b9\u306f3\u9031\u9593\uff0c8\u30b3\u30fc\u30b9\u884c\u3046\u3068\u3044\u3046\u8a66\u9a13\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002\u3053\u306e3\u9031\u9593\u30921\u30b3\u30fc\u30b9\u3068\u3057\u3001\u7b2c8\u30b3\u30fc\u30b9\u76ee\uff0824\u9031\uff09\u307e\u3067\u5b9f\u65bd\u3055\u308c\u307e\u3059\u3002ONC201\u306f\uff0c\u30c9\u30d1\u30df\u30f3D2 \u53d7\u5bb9\u4f53dopamine receptor D2\/3\u62ee\u6297\u85ac\uff08\u4f4e\u5206\u5b50\u5316\u5408\u7269\uff09\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\uff08\u526f\u4f5c\u7528\uff09\u306f\u6bd4\u8f03\u7684\u5c11\u306a\u3044\u85ac\u5264\u3067\u3059\u3002450\u4f8b\u306e\u7121\u4f5c\u70ba\u8a66\u9a13\u304c\u4e88\u5b9a\u3055\u308c\u3066\u3044\u3066\uff0c\u3053\u306e\u8a66\u9a13\u7d50\u679c\u304c\u3067\u308b\u306e\u306f2026\u5e74\u7d42\u4e86\u4e88\u5b9a\u3067\u3059\u304b\u3089\uff0c\u8a66\u9a13\u306b\u6210\u529f\u3057\u3066\u3082\u767a\u58f2\u3055\u308c\u308b\u306e\u306f\u3055\u3089\u306b\u5f8c\u306b\u306a\u308a\u307e\u3059\u3002\u6b8b\u5ff5\u306a\u304c\u3089<span style=\"color: #000080;\"><strong>DIPG\u306f\u8a66\u9a13\u5bfe\u8c61\u3068\u306a\u308a\u307e\u305b\u3093\u3002<br \/>\n<\/strong><span style=\"color: #333333;\">ONC201\u306f\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u306eL-2HG\u3092\u5897\u52a0\u3057\u3066\u816b\u760d\u7d30\u80de\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/span><\/span><\/p>\n<div class=\"setumei\">\n<h5><a href=\"https:\/\/www.ncc.go.jp\/jp\/ncch\/division\/clinical_trial\/patient\/to_patients\/03\/T5272.html\">\u56fd\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u306eONC201\u81e8\u5e8a\u8a66\u9a13<\/a><br \/>\nhttps:\/\/www.ncc.go.jp\/jp\/ncch\/division\/clinical_trial\/patient\/to_patients\/03\/T5272.html<\/h5>\n<\/div>\n<ul>\n<li>2025\u5e744\u6708\u306b\u65e5\u672c\u3067\u3082\u958b\u59cb\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u6295\u4e0e\u85ac\u5264\u306f\uff0c\u90311\u56de\u3042\u308b\u3044\u306f2\u56de\u306eONC201\u3067\u3059<\/li>\n<li>\u5bfe\u8c61\u306f\uff0cH3K27M\u5909\u7570\u304c\u3042\u308b\u3068\u8a3c\u660e\u3055\u308c\u305f\u3073\u307e\u3093\u6027\u795e\u7d4c\u81a0\u816b\u3067\u3059<\/li>\n<li>DIPG\u306f\u9664\u5916\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<li>\u4f53\u91cd\u304c10kg\u4ee5\u4e0a\uff0c\u653e\u5c04\u7dda\u5024\u9577\u3092\u3059\u3067\u306b\u53d7\u3051\u3066\u3044\u308b\u3068\u3044\u3046\u3088\u3046\u306a\u6761\u4ef6\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3053\u306e\u8a66\u9a13\u306f\uff0c\u306f\u3063\u304d\u308a\u3057\u305f\u7d50\u679c\u3092\u51fa\u3059\u306e\u306b\u304b\u306a\u308a\u591a\u304f\u306e\u767b\u9332\u60a3\u8005\u3055\u3093\u304c\u5fc5\u8981\u3067\u3059\uff0c\u304a\u305d\u3089\u304f\u5341\u5206\u306a\u7d50\u679c\u306f\u51fa\u306a\u3044\u3067\u7d42\u4e86\u3059\u308b\u3068\u3044\u3046\uff0c\u4eca\u307e\u3067\u306e\u65e5\u672c\u306e\u81e8\u5e8a\u8a66\u9a13\u3068\u540c\u3058\u8f4d\u3092\u8e0f\u3080\u306e\u3067\u3057\u3087\u3046<\/li>\n<li>\u3067\u3082\uff0cONC201\u304c\u65e5\u672c\u3067\u4f7f\u7528\u3067\u304d\u308b\u552f\u4e00\u306e\u7a93\u53e3\u3067\u3059<\/li>\n<\/ul>\n<h5 class=\"solo_record\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"http:\/\/dipgregistry.org\/clinical-trials\/\">DIPG registry<\/a><\/span>\uff08\u65b0\u305f\u306a\u85ac\u5264\u306e\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\u30ea\u30b9\u30c8\uff09<\/h5>\n<p class=\"solo_record\">\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u3078\u306e\u81e8\u5e8a\u8a66\u9a13\u306fDIPG registry\u3068\u3044\u3046\u30da\u30fc\u30b8\u306b\u3042\u308a\u307e\u3059\u3002\u82f1\u8a9e\u3067\u3059\u304c\u3055\u307e\u3056\u307e\u306a\u8a66\u9a13\u304c\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u591a\u304f\u306f\u81e8\u5e8a\u7b2c\uff11\u76f8\u3068\u3044\u3046\u5b9f\u9a13\u7684\u306a\u30ec\u30d9\u30eb\u306e\u3082\u306e\u3067\u3059\u3002<\/p>\n<\/div>\n<h4><strong>\u00a0\u6cbb\u7642\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b<\/strong><\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf1braistem.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2062\" title=\"33.jpg\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/nf1braistem.jpg\" alt=\"\" width=\"600\" height=\"313\" \/><\/a>\u3053\u308c\u306f\u795e\u7d4c\u7dda\u7dad\u816b\u75c71\u578b NF-1 \u306e\u5b50\u3069\u3082\u306b\u3067\u304d\u305f\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b (? \u3067\u3059\u3002\u4f55\u306e\u6cbb\u7642\u3082\u3057\u306a\u304f\u3066\u3082\u81ea\u7136\u306b\u3088\u304f\u306a\u308b\uff08\u81ea\u7136\u9000\u7e2e\uff09\u306e\u3067\u6cbb\u7642\u306e\u5fc5\u8981\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u9ad8\u7dda\u91cf\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3059\u308b\u3079\u304d\u3067\u306a\u304b\u3063\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u8133\u5e79\u90e8\u75c5\u5909\uff1aDIPG ???<\/h4>\n<p>\u6642\u3068\u3057\u3066\uff0cDIPG\u306e\u753b\u50cf\u8a3a\u65ad\u306f\u96e3\u3057\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>7\u6b73\u5973\u5150\u3067\u3059\uff0c\u767a\u71b1\u306e\u5f8c\u3067\u53f3\u5916\u8ee2\u795e\u7d4c\u9ebb\u75fa\u304c\u751f\u3058\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\uff0c\u5de6\u5916\u8ee2\u795e\u7d4c\u4e0d\u5168\u9ebb\u75fa\u3002\u7fcc\u5e74\u306b\uff0c\u8efd\u5ea6\u306e\u56a5\u4e0b\u969c\u5bb3\uff0c\u55c4\u58f0\uff0c\u8efd\u5ea6\u306e\u56db\u80a2\u5931\u8abf\u304c\u51fa\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u7fcc\u5e748\u6b73\u6642\u306bMRI\u306b\u3066\u8133\u5e79\u90e8\u75c5\u5909\u3092\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e21\u5074\u77b3\u5b54\u6563\u5927\uff0c\u53f3\u9854\u9762\u795e\u7d4c\u9ebb\u75fa\uff0c\u4f53\u611f\u5931\u8abf\u306a\u3069\u52a0\u308f\u308a\uff0cDIPG\u306e\u8a3a\u65ad\u306754\u30b0\u30ec\u30a427\u5206\u5272\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u7167\u5c04\u4e2d\uff12\u9031\u9593\u304f\u3089\u3044\u3067\u75c7\u72b6\u306e\u9032\u884c\u304c\u6b62\u307e\u308a\uff0c\u6539\u5584\u50be\u5411\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u7167\u5c04\u7d42\u4e86\u6642\u306b\u306f\u8133\u5e79\u75c5\u5909\u306f\u8457\u3057\u304f\u7e2e\u5c0f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20954\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm1-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20955\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm2-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20957\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm4-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20958\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm5-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20959\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm6-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20963\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm7-1-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><\/p>\n<p>\u3053\u308c\u306fDIPG\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u4e2d\u8133\u88ab\u84cb\uff0c\u6a4b\u88ab\u84cb\uff0c\u5ef6\u9ac4\u304c\u816b\u5927\u3057\u3066\u3044\u307e\u3059\u3002\u53f3\u4e0b\u4e2d\u8133\u811a\u306e\u816b\u5927\u3068\u5ef6\u9ac4\u306e\u80a5\u5927\u304c\u76ee\u7acb\u3061\u307e\u3059\u3002\u9006\u306b\u8133\u6a4b\u8179\u5074\u306e\u816b\u5927\u306f\u8efd\u5ea6\u3067\u3059\u3002\u62e1\u6563\u5f37\u8abf\u306f\u7b49\u4fe1\u53f7\u3067\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u307e\u305b\u3093\u3002\u58ca\u6b7b\u3084\u306e\u3046\u80de\u5f62\u6210\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3002DIPG\u3068\u3057\u3066\u306f\uff0c\u6a4b\u5e95\u90e8\u306e\u7570\u5e38\u4fe1\u53f7\u304c\u8efd\u5ea6\u306a\u3053\u3068\u304c\u975e\u5178\u578b\u7684\u3067\u3059\u3002\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u3068\u547c\u3070\u308c\u307e\u3059\u304c\uff0c\u6a4b\u306e\u4fe1\u53f7\u304c\u3073\u307e\u3093\u6027\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff0cDIPG\u306e\u7279\u5fb4\u3067\u3042\u308bhomogenous high-signal\u304c\u306a\u3044\u306e\u3067\u3059\u3002DIPG\u306f\u5ef6\u9ac4\u304b\u3089\u4e2d\u8133\u307e\u3067\u9032\u5c55\u3059\u308b\u3053\u3068\u306f\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u3073\u307e\u3093\u6027\u306b\u9023\u7d9a\u6027\u306bmass effect\u3092\u6709\u3057\u3066\u9023\u7d9a\u6027\u816b\u760d\u6027\u75c5\u5909\u3068\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u9006\u306b\u307e\u3060\u3089\u306a\u9ad8\u4fe1\u53f7\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20961\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm8-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20962\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-276x300.jpg\" alt=\"\" width=\"276\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-276x300.jpg 276w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-550x597.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-768x834.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-1414x1536.jpg 1414w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/dipgkm9-1886x2048.jpg 1886w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><\/p>\n<p>\u6cbb\u7642\u5f8c\u534a\u5e74\u306eMRI\u3067\u3059\u3002\u75c5\u5909\u306f\u307b\u307c\u5b8c\u5168\u306b\u6d88\u5931\u3057\u3066\u3044\u307e\u3059\u3002\u53f3\u5916\u8ee2\u795e\u7d4c\u9ebb\u75fa\uff08\u5f8c\u306b\u77ef\u6b63\u624b\u8853\u3057\u307e\u3057\u305f\uff09\u306e\u307f\u3092\u6b8b\u3057\uff0c\u30de\u30e9\u30bd\u30f3\u3082\u3067\u304d\u308b\u304f\u3089\u3044\u306b\u75c7\u72b6\u306f\u56de\u5fa9\u3057\uff0c\u767a\u75c7\u5f8c10\u5e74\u4ee5\u4e0a\u306b\u306a\u308a\u307e\u3059\u304c\uff0c\u666e\u901a\u306b\u901a\u5b66\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4f8b\u3067\u306f\uff0c\u611f\u67d3\u306b\u3088\u308b\u4e9c\u6025\u6027\u306e\u8133\u5e79\u8133\u708e localized brain enchephalitis\u3084\u611f\u67d3\u5f8c\u8133\u75c7 (ADEM)\u306a\u3069\u304c\u7591\u308f\u308c\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3082\u3057\u304b\u3057\u3066\uff0c\u30b9\u30c6\u30ed\u30a4\u30c9\u6cbb\u7642\u3092\u307e\u305a\u4f7f\u7528\u3057\u3066\u307f\u308b\u3079\u304d\u3060\u3063\u305f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<hr \/>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-10037\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4-185x300.jpg\" alt=\"\" width=\"185\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4-185x300.jpg 185w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4-768x1248.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4-369x600.jpg 369w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/soloillust4.jpg 1303w\" sizes=\"auto, (max-width: 185px) 100vw, 185px\" \/><\/a><\/p>\n<h5>\u3053\u3053\u304b\u3089\u4e0b\u306f\u6587\u732e\u306a\u306e\u3067\u96e3\u3057\u3044\u3067\u3059<\/h5>\n<h4>ONC201\u306f\uff0c\u518d\u767a\u3057\u305f\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u308f\u305a\u304b\u306a\u304c\u3089\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u308b<\/h4>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Arrillaga-Romany I:\u00a0<\/span>ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma. J Clin Oncol 2024<br \/>\n50\u4f8b\u306e\u518d\u767a\u60a3\u8005\u3055\u3093\u3067ONC201\u306e\u52b9\u679c\u304c\u8a66\u3055\u308c\u307e\u3057\u305f\u3002\u6210\u4eba\u304c46\u540d\uff0c18\u6b73\u4ee5\u4e0b\u306f4\u540d\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u304b\u3089\u306f90\u65e5\u4ee5\u4e0a\u304c\u7d4c\u904e\u3057\u3066\u304a\u308a\uff0cPS\u306f60\u4ee5\u4e0a\u3067\uff0c\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b DIPG \u306f\u9664\u5916\u3055\u308c\u3066\u3044\u307e\u3059\u3002ORR\uff08\u5168\u594f\u529f\u5272\u5408 RANO-HGG\uff09\u306f20\uff05\u3067\u3057\u305f\u3002TTR\u4e2d\u592e\u5024\u306f8.3\u30f6\u6708\uff0cDOR\uff08\u6709\u52b9\u671f\u9593\uff09\u4e2d\u592e\u5024\u306f11.2 \u30f6\u6708\u3067\u3057\u305f\u3002PS\u306e\u6539\u5584\uff08\u75c7\u72b6\u306e\u6539\u5584\uff09\u306f\u8a55\u4fa1\u3057\u3046\u308b34\u4eba\u306e\u51856\u4eba\u306b\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>H3K27\u5909\u7570\u306e\u3042\u308b\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u5bfe\u3059\u308b\uff0cONC201\u3068Paxalisib\u306e\u4f75\u7528<\/h4>\n<p class=\"heading-title\">ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma. Cancer Res 2023<br \/>\nPIK3CA\u5909\u7570\u3092\u6709\u3059\u308bDIPG\uff08\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\uff09\u306fONC201\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u3044\u3068\u4eee\u5b9a\u3055\u308c\u307e\u3059\u3002PI3K\/mTOR\u963b\u5bb3\u85ac\u3067\u3042\u308bPaxalisib\u3092ONC201\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u81e8\u5e8a\u7b2c2\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u3067\u3059\u3002<\/p>\n<h4>3\u6b73\u4ee5\u4e0b\u306eDIPG\u306e\u751f\u5b58\u671f\u9593\u306f\u5c11\u3057\u9577\u3044<\/h4>\n<p>Bartlett A: Characteristics of Children \u226436 Months of Age with Diffuse Intrinsic Pontine Glioma (DIPG): A Report from the International DIPG Registry. Neuro Oncol 2022<br \/>\n\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f15\u30f6\u6708\u3067\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u306a\u304b\u3063\u305f\u5b50\u306e\u751f\u5b58\u671f\u9593\u306f2\u30f6\u6708\u3067\uff0c\u53d7\u3051\u305f\u5b50\u306f17\u30f6\u6708\u3067\u3057\u305f\u30025\u5e74\u4ee5\u4e0a\u751f\u5b58\u3057\u305f\u5b50\u304c3\u4f8b\uff087.5%) \u3044\u307e\u3057\u305f\u3002<\/p>\n<h4 class=\"heading-title\">T2-FLAIR\u30df\u30b9\u30de\u30c3\u30c1\u304c\u307f\u3089\u308c\u308bDIPG\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u3088\u304f\u53cd\u5fdc\u3059\u308b<\/h4>\n<p class=\"heading-title\">Yamasaki F: T2-FLAIR Mismatch Sign and Response to Radiotherapy in Diffuse Intrinsic Pontine Glioma. Pediatr Neurosurg 2021<br \/>\n21\u4f8b\u306eDIPG\u3092\u8abf\u3079\u3066\uff0cFLAIR\u753b\u50cf\u3067\u5468\u56f2\u304c\u9ad8\u4fe1\u53f7\u306b\u7e01\u53d6\u308a\u3055\u308c\u5185\u90e8\u304c\u4f4e\u4fe1\u53f7\u306b\u306a\u308bT2-FLAIR mismatch sign\u304c5\u4f8b\u306b\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002DIPG\u306e25%\u304f\u3089\u3044\u3067\u3059\u3002\u3053\u306e5\u4f8b\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642(54Gy\/30fr)\u3067\u660e\u3089\u304b\u306a\u816b\u760d\u7e2e\u5c0f\u304c\u5f97\u3089\u308c\uff0c\u4e88\u5f8c\u304c\u6bd4\u8f03\u7684\u306b\u826f\u304b\u3063\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\uff0c\u30df\u30b9\u30de\u30c3\u30c1\u304c\u306a\u3044\u4f8b\u3067\u306f\u653e\u5c04\u7dda\u306e\u594f\u529f\u304c\u8a8d\u3081\u3089\u308c\u305f\u306e\u306f4\u4eba\u306b\u4e00\u4eba\u304f\u3089\u3044\u3067\u3057\u305f\u3002<\/p>\n<h4>\u967d\u5b50\u7dda\u6cbb\u7642\u306f\u5f93\u6765\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u6bd4\u8f03\u3057\u3066\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3057\u306a\u3044<\/h4>\n<p>Muroi A: Proton therapy for newly diagnosed pediatric diffuse intrinsic pontine glioma. <span class=\"docsum-journal-citation full-journal-citation\">Childs Nerv Syst. 2020<br \/>\n\u7b51\u6ce2\u5927\u5b66\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u300212\u4f8b\u306eDIPG\u306e\u5b50\u4f9b\u306b54Gy30\u5206\u5272\u306e\u967d\u5b50\u7dda\u6cbb\u7642\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u7d50\u679c\uff0cOS \u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u306f\u5f97\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n<h4>\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5206\u5272\u56de\u6570\u306f\u591a\u3059\u304e\u3066\u3082\u5c11\u306a\u3059\u304e\u3066\u3082\u751f\u5b58\u671f\u9593\u304c\u77ed\u304f\u306a\u308b<\/h4>\n<p><span class=\"authors-list-item \">Gallitto M:\u00a0<\/span>Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review. Adv Radiat Oncol 2019<br \/>\n\u591a\u304f\u306e\u6587\u732e\u30c7\u30fc\u30bf\u3092\u96c6\u7a4d\u3057\u305f\u7d50\u679c\u3067\u3059\u3002\u901a\u5e38\u306e\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u5206\u5272\u56de\u6570\u3092\u5897\u3084\u3057\u305f\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u6cbb\u7642\u671f\u9593\u3092\u77ed\u304f\u3057\u305f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u6210\u7e3e\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002\u901a\u5e38\u306e\u5206\u5272\u56de\u6570\u306e\u653e\u5c04\u7dda\u6cbb\u7642 (conventional RT, 1\u65e5\u7dda\u91cf1.8\u30b0\u30ec\u30a4\u306a\u3069\uff09\u3092\u53d7\u3051\u305f1,286\u4eba\u3067\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f12\u30f6\u6708\uff0c\u591a\u6570\u56de\u306b\u5206\u3051\u305f\u7167\u5c04 hyperfractionated RT (348\u4eba) \u3067\u306f10.2\u30f6\u6708\uff0c1\u65e5\u7dda\u91cf\u3092\u591a\u304f\u3059\u308b\u7167\u5c04 hypofractionated RT\u00a0(92\u4eba) \u3067\u306f7.9\u30f6\u6708\u3067\u3057\u305f\u30021\u65e5\u7dda\u91cf\u3092\u591a\u304f\u3057\u3066\u77ed\u671f\u9593\u3067\u6cbb\u7642\u3059\u308b\u3053\u3068\u3082\uff0c\u4e00\u56de\u7dda\u91cf\u3092\u5c0f\u3055\u304f\u3057\u3066\u591a\u6570\u56de\u7167\u5c04\u3059\u308b\u3053\u3068\u306b\u3082\u5229\u70b9\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>OCN201\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76<\/h4>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Chi AS:\u00a0<\/span>Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201. J Neurooncol 2019<br \/>\n\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u3042\u308b\u3044\u306f\u518d\u71c3\u3057\u305f18\u4f8b\u306eH3 K27M mutant glioma\u306b\u9031\u4e00\u56de\u306eOCN201\u306e\u6295\u4e0e\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u518d\u71c3\u3057\u305f\u6210\u4eba3\u4f8b\u30671\u5e74\u8fd1\u3044\u7121\u5897\u60aa\u751f\u5b58\u304c\u5f97\u3089\u308c\uff0c\uff14\u4f8b\u306e\u5c0f\u5150DIPG\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3059\u3050\u5f8c\u3067OCN201\u3092\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\uff0c2\u4f8b\u304c53\u9031\u306881\u9031\u7121\u5897\u60aa\u751f\u5b58\u3057\u3066\u3044\u308b\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>DRD2\/3\u62ee\u6297\u5264 ONC210\u306e\u65b0\u305f\u306a\u75c7\u4f8b\u5831\u544a<\/h4>\n<p>Chi AS: Pediatric and adult <span class=\"highlight\">H3<\/span> <span class=\"highlight\">K27M-mutant<\/span> diffuse midline <span class=\"highlight\">glioma<\/span> treated with the selective DRD2 antagonist <span class=\"highlight\">ONC201<\/span>. <span role=\"menubar\">J Neurooncol.<\/span> 2019<br \/>\n\u4e0b\u306e\u8ad6\u6587\u3068\u540c\u3058\u8a66\u9a13\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306b\u518d\u71c3\u3057\u305f\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u309318\u4eba\u304c\u5bfe\u8c61\u3068\u3055\u308c\u307e\u3057\u305f\u3002\u6210\u4eba\u4f8b7\u4eba\u4e2d\u306e3\u4eba\u3067\u816b\u760d\u518d\u767a\u304c\u6291\u3048\u3089\u308c\uff0c49\u9031\u9593\uff081\u5e74\uff09\u4ee5\u4e0a\u306b\u308f\u305f\u308a\u306a\u304a\u85ac\u5264\u6295\u4e0e\u304c\u7d99\u7d9a\u4e2d\u3067\u3059\u30024\u4eba\u306e\u5c0f\u5150\u306e\u3046\u3061DIPG\u306e2\u4eba\u304c53\u9031\u306881\u9031\u3067\u5897\u60aa\u304c\u306a\u3044\u72b6\u614b\u3067\u7dad\u6301\u3067\u304d\u3066\u3044\u307e\u3059\u3002\u8996\u5e8a\u3068\u6a4b\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u4f8b\u3067\u753b\u50cf\u4e0a\u3067\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306f\u81e8\u5e8a\u7b2c\uff12\u76f8\u8a66\u9a13\u304c\u884c\u308f\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n<h4>\u5c0f\u5150DIPG: DRD2\/3\u62ee\u6297\u5264 ONC210\u306e\u521d\u3081\u3066\u306e\u81e8\u5e8a\u4f7f\u7528\u4f8b<\/h4>\n<p>Hall MD: First clinical experience with DRD2\/3 antagonist <span class=\"highlight\">ONC201<\/span> in <span class=\"highlight\">H3<\/span> <span class=\"highlight\">K27M<\/span>-mutant pediatric diffuse intrinsic pontine glioma: a case report. <span role=\"menubar\">J Neurosurg Pediatr.<\/span> 2019<br \/>\nH3 K27M\u5909\u7570\u3092\u6709\u3059\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u306f\uff0c\u30c9\u30d1\u30df\u30f3\u53d7\u5bb9\u4f53DRD2\u3092\u904e\u5270\u767a\u73fe\u3057\uff0cDRD5\u3092\u6291\u5236\u3057\u3066\u3044\u307e\u3059\u3002ONC201\u306fDRD2\u62ee\u6297\u5264\u3067\u3059\u300210\u6b73\u306e\u5973\u306e\u5b50\u304c\u5b9a\u4f4d\u8133\u751f\u691c\u8853\u3067H3 K27M\u5909\u7570\u304c\u3042\u308bDIPG\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306e1\u30f6\u6708\u5f8c\u306b\uff0cONC201\u306e\u6295\u4e0e\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u816b\u760d\u306f\u5f90\u3005\u306b\u7e2e\u5c0f\u3057\u3066\u75c7\u72b6\u306f\u6539\u5584\u3057\u307e\u3057\u305f\u3002ONC201\u6cbb\u76421\u5e74\u5f8c\u306b\u7167\u5c04\u91ce\u5916\u306b\uff12\u3064\u306e\u75c5\u5909\u304c\u51fa\u73fe\u3057\u305f\u306e\u3067\uff0c\u30b9\u30c6\u30ed\u30a4\u30c9\uff0c\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\uff0c\u8ffd\u52a0\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u6cbb\u7642\u304c\u52a0\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u8a3a\u65ad\u4ee5\u676522\u30f6\u6708\uff0c\u75c7\u72b6\u306f\u6539\u5584\u3057\u3066\u305d\u306e\u5f8c\u306e\u816b\u760d\u5897\u5927\u306f\u306a\u3044\u305d\u3046\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u6b8b\u5ff5\u306a\u304c\u3089\u7d4c\u904e\u89b3\u5bdf\u304c22\u30f6\u6708\u307e\u3067\u3057\u304b\u306a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002ONC201\u5f8c\u306b\u518d\u71c3\u3057\u3066\u518d\u7167\u5c04\u304c\u52a0\u3048\u3089\u308c\u3066\u3044\u3066\uff0cPFS 22\u30f6\u6708\u3068\u3044\u3046\u306e\u306fDIPG\u3067\u306f\u3055\u307b\u3069\u73cd\u3057\u304f\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u306a\u3093\u3068\u3082\u8a55\u4fa1\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<h4>\u751f\u691c\u8853\u306e\u5b89\u5168\u6027\u306f\u9ad8\u3044?\uff1f<\/h4>\n<p>Prospective\u00a0feasibility\u00a0and\u00a0safety\u00a0assessment\u00a0of\u00a0surgical\u00a0biopsy\u00a0for patients with newly diagnosed diffuse intrinsic pontine glioma.\u00a0Gupta N, Neuro Oncol.\u00a02018<br \/>\n50\u4eba\u306eDIPG\u306e\u5b50\u4f9b\uff08\u4e2d\u592e\u50246\u6b73\uff09\u304c\u751f\u691c\u8853\u306e\u5f8c\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30d9\u30d0\u30b7\u30ba\u30de\u30d6\u306e\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002MGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3068EGFR\u306e\u767a\u73fe\u306b\u3088\u3063\u3066\uff0c\u30a8\u30ed\u30c1\u30cb\u30d6\u304b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6295\u4e0e\u306e\u662f\u975e\u3092\u5224\u65ad\u3057\u3066\u7dad\u6301\u7642\u6cd5\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u4e00\u4eba\u306e\u60a3\u5150\u304c\u624b\u8853\u306b\u3088\u3063\u3066\u56de\u5fa9\u3057\u306a\u3044\u5de6\u534a\u8eab\u9ebb\u75fa\uff08\u624b\u8853\u5408\u4f75\u75c7\uff09\u3092\u751f\u3058\u307e\u3057\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\uff0c\u751f\u691c\u8853\u306f\u5b89\u5168\u306b\u884c\u3048\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8ad6\u6587\u306e\u4e2d\u3067\uff0c\u6cbb\u7642\u6210\u7e3e\u306f\u516c\u8868\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<br \/>\n\u3053\u306e\u8ad6\u6587\u3092\u8a73\u3057\u304f\u8aad\u3080\u3068\uff0c50\u4eba\u306e\u5b50\u4f9b\u305f\u3061\u304c\u751f\u691c\u8853\uff08neuronavigation biopsy) \u3092\u53d7\u3051\uff0c\u65bd\u8853\u5f8c14\u65e5\u4ee5\u5185\u306b\uff0c\u7121\u547c\u54382\u4eba\uff0c\u610f\u8b58\u969c\u5bb33\u4eba\uff0c\u547c\u5438\u969c\u5bb32\u4eba\uff0c\u8840\u816b1\u4eba\uff0c\u6c34\u982d\u75c73\u4eba\uff0c\u4f4e\u8840\u57271\u4eba\uff0c\u982d\u84cb\u5185\u51fa\u88402\u4eba\uff0c\u50be\u7720\u50be\u54111\u4eba\uff0c\u547c\u5438\u4e0d\u51681\u4eba\u304c\u751f\u3058\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u65b0\u898f\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u5150\u306f\u4e00\u4eba\u3082\u3044\u307e\u305b\u3093\u3002\u751f\u5b58\u671f\u9593\u304c\u5ef6\u9577\u3055\u308c\u305f\u53ef\u80fd\u6027\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002<br \/>\n\u982d\u304c\u304a\u304b\u3057\u3044\u4eba\u3067\u306a\u3051\u308c\u3070\uff0c2018\u5e74\u6642\u70b9\u3067\uff0c\u751f\u691c\u8853\u3068\u3044\u3046\u304a\u305d\u308d\u3057\u3044\u8a3a\u65ad\u6cd5\u3092\u53d7\u3051\u3066\u3082\u306a\u3093\u306e\u5229\u76ca\u3082\u898b\u8fd4\u308a\u3082\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u3082\u4f53\u5236\u306e\u6574\u308f\u306a\u3044\u65e5\u672c\u3067\u884c\u308f\u308c\u308b\u3079\u304d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u9ac4\u6db2\u3068\u8840\u6db2\u3067\u907a\u4f1d\u5b50\u8a3a\u65ad\u3059\u308b\uff1a<strong><span style=\"color: #000080;\">liquid biopsy<\/span><\/strong><\/h4>\n<p>Panditharatna E et al.: Invasive\u00a0Tumor\u00a0Surveillance\u00a0of\u00a0Pediatric\u00a0Diffuse\u00a0Midline\u00a0Gliomas\u00a0Using Patient-Derived Liquid Biopsy.\u00a0Clin Cancer Res. (2018)<br \/>\n\u753b\u50cf\u3067\u816b\u760d\u518d\u71c3\u304b\u3069\u3046\u304b\u8ff7\u3063\u305f\u6642\u306b\uff0c\u8840\u6db2\u3068\u9ac4\u6db2\u3067H3K27M\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u8ad6\u6587\u3067\u3059\u3002circulating <span class=\"highlight\">tumor<\/span> DNA (ctDNA) \u3092\u8abf\u3079\u308b\u306e\u3067\uff0cliquid biopsy\u3068\u3044\u308f\u308c\u307e\u3059\u3002\u60a3\u5150\u304b\u3089\u63a1\u53d6\u3057\u305f\u9ac4\u6db2\u3068\u8840\u6db2\u3092droplet digital PCR\u8abf\u3079\u305f\u3089\uff0c48\u4eba\u4e2d\uff0c42\u4eba(88%)\u3067H3K27M \u5909\u7570\u304c\u691c\u51fa\u3067\u304d\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>2\u5e74\u4ee5\u4e0a\u751f\u306e\u751f\u5b58\u4f8b\u306e\u7279\u5fb4<\/h4>\n<p><span class=\"highlight\">Hoffman LM, et al.: Clinical<\/span>, <span class=\"highlight\">Radiologic<\/span>, <span class=\"highlight\">Pathologic<\/span>, and <span class=\"highlight\">Molecular<\/span> <span class=\"highlight\">Characteristics<\/span> of <span class=\"highlight\">Long-Term<\/span> <span class=\"highlight\">Survivors<\/span> of <span class=\"highlight\">Diffuse<\/span>Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.\u00a0<span role=\"menubar\">J Clin Oncol.<\/span> 2018<br \/>\n1,008\u4f8b\u306e\u30c7\u30fc\u30bf\u5206\u6790\u3067\u3059\u3002101\u4f8b(10%)\u304c2\u5e74\u4ee5\u4e0a\u751f\u5b58\u3057\uff0c5\u5e74\u751f\u5b58\u5272\u5408\u306f2%\u3067\u3059\u30022\u5e74\u4ee5\u4e0a\u306e\u751f\u5b58\u8005\u306f\uff0c3\u6b73\u672a\u6e80\u306811\u6b73\u4ee5\u4e0a\u3067\u767a\u75c7\u3057\u305f\u5b50\u4f9b\u304c\u591a\u304f\uff0c\u8a3a\u65ad\u307e\u3067\u306e\u75c7\u72b6\u306e\u7d99\u7d9a\u671f\u9593\u304c\u9577\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u751f\u5b58\u671f\u9593\u304c\u77ed\u3044\u4f8b\u3067\u306e\u7279\u5fb4\u306f\uff0c\u30ea\u30f3\u30b0\u72b6\u306e\u5897\u5f37\u6240\u898b\uff0c\u816b\u760d\u58ca\u6b7b\u6240\u898b\uff0c\u8133\u69fd\u5185\u816b\u760d\u767a\u80b2\uff0c\u8133\u795e\u7d4c\u9ebb\u75fa\u767a\u75c7\uff0c<em>HIST1H3B<\/em>\u5909\u7570\u3067\u3059\u3002<\/p>\n<h4>\u751f\u5b58\u671f\u9593\u306f11\u30f6\u6708<\/h4>\n<p>Veldhuijzen van Zanten SE, et al.:\u00a0Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol.\u00a02017<br \/>\n\u30e8\u30fc\u30ed\u30c3\u30d1\u306e694\u4f8b\u306e\u7d71\u8a08\u5024\u3067\u3059\u3002\u75c7\u72b6\u304c\u60aa\u5316\u3059\u308b\u307e\u3067\u306e\u671f\u9593\u306f6\u30f6\u6708\uff0c\u751f\u5b58\u671f\u9593\u306f11\u30f6\u6708\uff0c2\u5e74\u751f\u5b58\u7387\u306f10%\uff0c5\u5e74\u751f\u5b58\u7387\u306f2%\u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4>\u518d\u71c3\u3057\u305f\u6642\u306e\u518d\u7167\u5c04<\/h4>\n<p>Janssens GO, et al.:\u00a0Survival benefit for patients with\u00a0diffuse\u00a0intrinsic\u00a0pontine\u00a0glioma\u00a0(DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG\/DIPG working group. Eur J Cancer,\u00a02017<br \/>\n31\u4eba\u306e\u5b50\u3069\u3082\u304c\u518d\u767a\uff08\u518d\u71c3\u75c7\u72b6\u60aa\u5316\uff09\u3057\u305f\u6642\u306b\u518d\u7167\u5c04 (dose 19.8-30.0\u00a0Gy)\u3092\u53d7\u3051\u307e\u3057\u305f\u300277%\u3067\u307e\u305f\u75c7\u72b6\u306e\u6539\u5584\u304c\u5f97\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3067\u3082\u751f\u5b58\u671f\u9593\u306f\u308f\u305a\u304b\u306b\u4f38\u3073\u308b\u306e\u307f\u3067\u3059\u3002\u307e\u305f\u521d\u56de\u6cbb\u7642\u304b\u3089\u518d\u71c3\u9032\u884c\u307e\u3067\u306e\u671f\u9593\u304c\u9577\u304b\u3063\u305f\u5b50\u306b\u6709\u52b9\u6027\u304c\u9ad8\u304b\u3063\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306f2\u5ea6\u76ee\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u306f\u3042\u307e\u308a\u7528\u3044\u3089\u308c\u307e\u305b\u3093\u3002\u3067\u3082\u521d\u56de\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u304b\u306a\u308a\u52b9\u3044\u305f\u5b50\u306f\u5bdb\u89e3\u5c0e\u5165\u624b\u6bb5\u3068\u3057\u3066\u4e00\u3064\u306e\u9078\u629e\u80a2\u3067\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4><span style=\"color: #ff0000;\">\u751f\u691c\u624b\u8853\u306f\u5fc5\u8981\u306a\u306e\u304b<\/span><\/h4>\n<p>MacDonald TJ: Diffuse intrinsic pontine glioma (DIPG): Time to biopsy again?<br \/>\nDr. MacDoald\u306f\u5f37\u8abf\u3057\u307e\u3059\uff0c\u624b\u8853\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u304f\u306a\u3063\u305f\u3068\u306f\u3044\u3048\u6b74\u7136\u3068\u3057\u3066\u3042\u308b\u3002\u3082\u3057\u751f\u691c\u8853\u304c\u5fc5\u8981\u306a\u3089\uff0c\u5c0f\u5150\u8133\u816b\u760d\u30bb\u30f3\u30bf\u30fc\u306e\u6b63\u5f0f\u306a\u81e8\u5e8a\u7814\u7a76\u306e\u3082\u3068\u3067\u719f\u7df4\u3057\u305f\u8133\u5916\u79d1\u533b\u304c\u884c\u3046\u3079\u304d\u3067\u3042\u308b\u3002The mere presence of an oncogenic mutation does not necessarily constitute a \u2018\u2018therapeutic target,\u2019\u2019 and thus treatment-making decisions based on these data would be premature and should be avoided. \u73fe\u5728\uff0c\u751f\u691c\u8853\u3092\u3057\u3066\u3082\u6cbb\u7642\u65b9\u91dd\u304c\u5909\u308f\u308b\u8a33\u3067\u306f\u306a\u3044\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u6b27\u7c73\u3067\u3082\u7a4d\u6975\u7684\u306b\u751f\u691c\u8853\u3092\u3059\u308b\u65bd\u8a2d\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u305d\u308c\u306f\u5c06\u6765\u306e\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306e\u305f\u3081\u306b\u7814\u7a76\u6750\u6599\u3068\u3057\u3066\u816b\u760d\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3059\u308b\u306e\u304c\u4e3b\u76ee\u7684\u3068\u306a\u308a\u307e\u3059\u3002<strong><span style=\"color: #000080;\">\u7c73\u56fd\u306b\u304a\u3044\u3066\u3082\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u751f\u691c\u8853\u304c\u3080\u3084\u307f\u306b\u8a31\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/strong>\u3002\u304b\u306a\u308a\u53b3\u3057\u3044\u81e8\u5e8a\u7814\u7a76\u76ee\u7684\u306e\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u4e0b\u306b\u884c\u3063\u3066\u3082\u3044\u3044\u3060\u3051\u3067\u3059\u3002\u65e5\u672c\u306b\u304a\u3044\u3066\u306f\u7814\u7a76\u4f53\u5236\u306f\u6574\u5099\u3055\u308c\u3066\u304a\u3089\u305a\uff0cMRI\u3067\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u8a3a\u65ad\u3055\u308c\u308b\u3082\u306e\u3092\u751f\u691c\u3057\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u8aa4\u3063\u305f\u8003\u3048\u65b9\u306f\uff0c\u300c\u60aa\u6027\u304b\u826f\u6027\u304b\u306f\u63a1\u3063\u3066\u307f\u306a\u3051\u308c\u3070\u89e3\u3089\u306a\u3044\u300d\u300c\u75c5\u7406\u6240\u898b\u304c\u6c7a\u5b9a\u3067\u304d\u306a\u3044\u3068\u6cbb\u7642\u65b9\u91dd\u304c\u6c7a\u307e\u3089\u306a\u3044\u300d\u3068\u3044\u3063\u3066\u610f\u5473\u306e\u306a\u3044\u624b\u8853\u3092\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #ff0000;\">\u30cb\u30e2\u30c4\u30ba\u30de\u30d6\u306e\u52b9\u679c<\/span><\/h4>\n<p>Bartels U, et al.: Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma. Neuro Oncol 16:1554-1559, 2014<br \/>\n\u518d\u71c3\uff08\u518d\u767a\uff09\u3057\u305f44\u4eba\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\uff08\u5e74\u9f62\u4e2d\u592e\u50246\u6b73\uff09\u306b\u305f\u3044\u3057\u3066\uff0c\u6297EGFR\u6297\u4f53\u3067\u3042\u308bNimotuzumab (150mg\/m2)\u304c\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u30021\u9031\u9593\u306b1\u56de\u3092\uff17\u9031\u9593\u6295\u4e0e\u3057\u3066\uff0c\u5f8c\u306f2\u9031\u9593\u306b1\u56de\u306e\u6295\u4e0e\u3067\u3059\u3002\uff18\u9031\u9593\u6295\u4e0e\uff082\u30f6\u6708\uff09\u304c\u3067\u304d\u305f19\u4eba\u306e\u5b50\u3069\u3082\u3067\uff0cPR 2\u4f8b\uff0cSD \uff16\u4f8b\u3067\u3057\u305f\u30025\u4eba\u306718\u9031\u9593\u306e\u6295\u4e0e\u304c\u3067\u304d\u307e\u3057\u305f\u300244\u4eba\u3067\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c3.2\u30f6\u6708\u3067\u3057\u305f\u30022\u4eba\u306e\u60a3\u5150\u304c\u30cb\u30e2\u30c4\u30ba\u30de\u30d6\u6295\u4e0e\u958b\u59cb\u304b\u3089\uff0c663\u65e5\u3068481\u65e5\u751f\u5b58\u3057\u307e\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u308f\u305a\u304b\u306a\u304c\u3089\u306e\u52b9\u679c (modest activity)\u304c\u3042\u308b\u3088\u3046\u3067\u3059\u300244\u4eba\u306e\u3046\u30618\u4eba (18%) \u3067\uff0c2\u30f6\u6708\u304f\u3089\u3044\u306f\u75c5\u52e2\u306e\u9032\u884c\u306f\u3068\u3069\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #ff0000;\">\u5206\u5272\u56de\u6570\u3092\u5c11\u306a\u304f\u3057\u3066\u77ed\u671f\u9593\u306e\u653e\u5c04\u7dda\u6cbb\u7642<span style=\"color: #000080;\">\u306b\u5229\u70b9\u304c\u3042\u308b\uff0c<\/span><\/span>\u3067\u3082\u8981\u6ce8\u610f<\/h4>\n<p>Janssens GO, et al.: The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study. Int J Radiat Oncol Biol Phys (Epub) 2008<br \/>\nZaghloul MS, et al.: Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial. Radiother Oncol. 2014 Feb 20<br \/>\n2008\u5e74\u306e\u8ad6\u6587\u3067\u306f\uff0c\uff13\u6b73\u304b\u308913\u6b73\u307e\u3067\uff0c\u3073\u307e\u3093\u6027\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306e9\u4eba\u304c\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u30023\u30b0\u30ec\u30a4\u309213\u56de\u3042\u308b\u3044\u306f5.5\u30b0\u30ec\u30a4\u3092\uff16\u56de\u3067\uff13\u9031\u9593\u3067\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u6e08\u307e\u305b \u3088\u3046\u3068\u3059\u308b\u8a66\u307f\u3067\u3059\u3002\u5168\u3066\u306e\u60a3\u5150\u3067\uff12\u9031\u9593\u4ee5\u5185\u306b\u75c7\u72b6\u306e\u6539\u5584\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u816b\u760d\u306e\u518d\u5897\u60aa (progression) \u307e\u3067\u306e\u671f\u9593\u4e2d\u592e\u5024\u306f4.9\u30f6\u6708\uff0c\u5168\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024(OS)\u306f8.6\u30f6\u6708\u3067\u3057\u305f\u30022014\u5e74\u306b\u66f8\u304b\u308c\u305f\u8ad6\u6587\u3067\u306f\uff0c79\u4eba\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u306e\u60a3\u5150\u304c\uff0c<span style=\"color: #000080;\"><strong>3\u30b0\u30ec\u30a4\u309213\u56de<\/strong><\/span>\u3042\u308b\u3044\u306f<span style=\"color: #000080;\"><strong>1.8\u30b0\u30ec\u30a4\u309230\u56de<\/strong><\/span>\u306e\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u4e21\u8005\u306b\u5dee\u306f\u306a\u304b\u3063\u305f\u306e\u3067\u77ed\u671f\u9593\u3067\u7d42\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b13\u5206\u5272\u306e\u65b9\u306b\u5229\u70b9\u304c\u3042\u308b\u3068\u306e\u7d50\u8ad6\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u8457\u8005\u304c\u7d50\u8ad6\u3067\u66f8\u3044\u3066\u3044\u308b\u3088\u3046\u306b\uff0c\u6cbb\u7642\u671f\u9593\u304c\u77ed\u3044\u3068\u3044\u3046\u306e\u304c\u3053\u306e\u6cbb\u7642\u6cd5\u306e\u5229\u70b9\u3067\u3059\u3002\u751f\u547d\u4e88\u5f8c\u304c\u77ed\u304f\u3069\u3046\u3057\u3066\u3082\u547d\u3092\u6551\u3048\u306a\u3044\u304b\u3089\u3053\u305d\uff0c\u77ed\u671f\u9593\u3067\u6cbb\u7642\u3092\u7d42\u3048\u3066\uff0c\u75c7\u72b6\u306e\u6539\u5584\u306e\u65e9\u3044\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u826f\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u304c\uff0c\u4e00\u65e5\u7dda\u91cf3\u30b0\u30ec\u30a4\u3067\u7dcf\u7dda\u91cf\u304c39\u30b0\u30ec\u30a4\u3068\u3044\u3046\uff0c\u304b\u306a\u308a\u5927\u91cf\u306e\u653e\u5c04\u7dda\u3092\u3057\u3088\u3046\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3059\u3002\u7279\u306b<span style=\"color: #000080;\"><strong>\u5e7c\u5150\u3067\u306f\u65e9\u671f\u306e\u653e\u5c04\u7dda\u58ca\u6b7b\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/strong><\/span>\u5f37\u5ea6\u306e\u9ad8\u3044\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u3044\u308f\u3056\u308b\u3092\u5f97\u307e\u305b\u3093\u3002\u307e\u305f\u3082\u3057\u3053\u306e\u6cbb\u7642\u306b\u52a0\u3048\u3066\uff0c<strong><span style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u6642\u306e\u30b9\u30fc\u30c9\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30e7\u30f3<\/span><\/strong>\u304c\u751f\u305a\u308c\u3070\uff0c\u7167\u5c04\u5f8c\u65e9\u671f\u306b\u8133\u5e79\u75c7\u72b6\u304c\u6025\u901f\u306b\u60aa\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n<h4>\u4e00\u56de\u7dda\u91cf\u3092\u9ad8\u304f\u3059\u308b\u653e\u5c04\u7dda\u6cbb\u7642<\/h4>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Janssens GO:\u00a0<\/span>Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis. Int J Radiat Oncol Biol Phys 2013<br \/>\n1\u56de3\u30b0\u30ec\u30a4\u3082\u3057\u304f\u306f2.8\u30b0\u30ec\u30a4\u3068\u3044\u3046\u5927\u304d\u306a\u7dda\u91cf\u3067\uff0c39-44.8\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u307e\u3059\u3002\u76ee\u7684\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u671f\u9593\u3092\u77ed\u304f\u3059\u308b\u3053\u3068\u3067\u3059\u3002\uff16\uff0c\uff19\uff0c12\u30f6\u6708\u3067\u306e\u5168\u751f\u5b58\u671f\u9593\u306f74%, 44%, 22%\u3067\u3057\u305f\u30028\u5272\u304c1\u5e74\u4ee5\u5185\u306b\u4ea1\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u306f\u5f93\u6765\u306e\u6210\u7e3e\u3068\u5909\u308f\u3089\u306a\u3044\u3068\u4e3b\u5f35\u3057\u307e\u3059\u304c\uff0c\u660e\u3089\u304b\u306b\u751f\u5b58\u671f\u9593\u3092\u77ed\u304f\u3057\u3066\u3044\u307e\u3059\u3002\u304a\u305d\u3089\u304f\u65e9\u671f\u306e\u8133\u5e79\u90e8\u306e\u653e\u5c04\u7dda\u58ca\u6b7b\u304c\u751f\u3058\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4><span style=\"color: #ff0000;\">\uff13\u6b73\u672a\u6e80\u306e\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306f\u4e88\u5f8c\u304c\u826f\u3044\u3053\u3068\u304c\u3042\u308b<\/span>\uff0c\u4f55\u304b\u9055\u3046<\/h4>\n<p>Broniscer A, et al.: Young age may predict a better outcome for children with diffuse pontine glioma. Cancer 113: 566-572, 2008<br \/>\n\uff13\u6b73\u306b\u6e80\u305f\u306a\u304410\u4eba\u306e\u3053\u3069\u3082\u306e\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de (diffuse pontine glioma)\u3092\u8abf\u3079\u305f\u5831\u544a\u3067\u3059\u30024\u4eba\u306e\u3053\u3069\u3082\u304c\u4ea1\u304f\u306a\u3063\u3066\uff0c\uff16\u4eba\u306e\u3053\u3069\u3082\u304c\u751f\u5b58\u3057\u3066\u3044\u305f\u3068\u306e\u4e8b\u3067\u3059\u3002 \uff13\u5e74\u306e\u6642\u70b9\u3067\u816b\u760d\u304c\u9032\u884c\u3057\u306a\u3044\u3067\u751f\u5b58\u3057\u3066\u3044\u305f\uff08\u7121\u5897\u60aa\u751f\u5b58\u7387\uff09\u306e\u306f45%\uff0c\u5168\u751f\u5b58\u7387\u306f69%\u3060\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u6cbb\u7642\u306f\uff0c\u653e\u5c04\u7dda\u306e\u307f\uff12\u4f8b\uff0c\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\uff16 \u4f8b\uff0c\u5316\u5b66\u7642\u6cd5\u306e\u307f\uff12\u4f8b\u3067\u3059\u3002\u3053\u306e\u751f\u5b58\u7387\u306f\uff0c\u3082\u3046\u5c11\u3057\u5e74\u9f62\u304c\u4e0a\u306e\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u3088\u308a\u9065\u304b\u306b\u3044\u3044\u3082\u306e\u3067\u3059\u3002\u66f8\u3044\u305f\u5148\u751f\u306f\uff0c\uff13\u6b73\u672a\u6e80\u306e\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306f\uff0c\u901a\u5e38\u306e \u3082\u306e\u3068\u306f\u751f\u7269\u5b66\u7684\u306b\u306a\u306b\u304b\u7570\u306a\u3063\u305f\u816b\u760d\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u4e00\u3064\u3060\u3051\u6ce8\u610f\u3057\u3066\u304a\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u30023\u6b73\u672a\u6e80\u306e\u5b50\u4f9b\u305f\u3061\u306f\u9aa8\u306e\u5897\u6b96\u901f\u5ea6\u304c\u901f\u3044\u3067\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u816b\u760d\u304c\u9855\u8457\u306b\u5897\u5927\u3057\u3066\u3082\u5f8c\u982d\u7aa9\u306e\u9aa8\u306e\u62e1\u5927\u3082\u65e9\u304f\u3066\u8133\u5e79\u90e8\u306e\u5727\u8feb\u75c7\u72b6\u3067\u3042\u308b\u610f\u8b58\u3084\u547c\u5438\u969c\u5bb3\u304c\u51fa\u308b\u306e\u304c\u9045\u3044\u3068\u3044\u3046\u4f8b\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4><strong><span style=\"color: #ff0000;\">\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u52b9\u679c\u304c\u306a\u3044<\/span><\/strong><\/h4>\n<p>Broniscer A, et al: Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98). Cancer 103:133-139, 2005<br \/>\n\u521d\u767a\u4f8b\u306e\u3073\u307e\u3093\u6027\u8133\u5e79\u90e8\u81a0\u816b29\u4f8b\uff08\u5e74\u9f62\u4e2d\u592e\u50246\u6b73\uff09\u306b\u5bfe\u3057\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306b\u540c\u69d8\u306a\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6295\u4e0e\uff08200mg\/m<sup>2<\/sup>\u3092\uff15\u65e5\u9593\u9023\u7d9a\u6295\u4e0e\uff09\u3092\u884c\u3063\u305f\u5831\u544a\u3067\u306f\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u502412\u30f6\u6708\u3067\u5168\u4f8b\u304c\u6b7b\u4ea1\u3057<span style=\"color: #000080;\"><strong>\u3073\u307e\u3093\u6027<\/strong><\/span><span style=\"color: #000080;\"><strong>\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044<\/strong><\/span>\u3068\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nJalali R , et al.: Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma. Int J Rad Oncol Biol Phys, 2009 (Epub)<br \/>\n\u3059\u3067\u306b\u540c\u69d8\u306e\u7d50\u679c\u306e\u8ad6\u6587\u306f\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u540c\u3058\u3053\u3068\u304c\u307e\u305f\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u300220\u4eba\u306e\u5b50\u4f9b\u304c\u6cbb\u7642\u3055\u308c\u305f\u306e\u3067\u3059\u304c<span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4e0a\u4e57\u305b\u52b9\u679c\u306f\u306a\u304f<\/strong><\/span>\uff0c\u653e\u5c04\u7dda\u5358\u72ec\u6cbb\u7642\u3068\u6bd4\u3079\u3066\u751f\u547d\u4e88\u5f8c\u306e\u6539\u5584\u306f\u306a\u304b\u3063\u305f\u3068\u3055\u308c\u307e\u3057\u305f\u3002\u3067\u3082\u8a73\u3057\u304f\u8aad\u3080\u3068\uff0c1\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u75c5\u6c17\u306e\u9032\u884c\u304c\u306a\u304f4\u5e74\u4ee5\u4e0a\u751f\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u60a3\u8005\u3055\u3093\u304c \u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u3067\u306f\u306a\u304f\u306a\u306b\u304b\u4ed6\u306e\u816b\u760d\u3060\u3063\u305f\u306e\u304b\u3069\u3046\u304b\u306f\u89e3\u308a\u307e\u305b\u3093\u304c\uff0c\u4f8b\u5916\u7684\u306b\u9577\u671f\u751f\u5b58\u4f8b\u304c\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<br \/>\nCohen KJ, et al.: Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children&#8217;s Oncology Group. Neuro Oncol 13:410-416, 2011<br \/>\nCOG\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u300262\u4eba\u306e\u5b50\u3069\u3082\u304c59.4Gy\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u671f\u9593\u4e2d\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9 90mg\/m2\u309242\u65e5\u9593\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306f\uff14\u9031\u306b\u30b5\u30a4\u30af\u30eb\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u3067\u3059\u30021\u5e74\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408 EFS\u306f14%\u3067\u3042\u308a\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3057\u306a\u304b\u3063\u305f\u904e\u53bb\u306e\u6210\u7e3e\u306e21.9%\u3092\u4e0b\u56de\u308a\u307e\u3057\u305f\u30021\u5e74\u5168\u751f\u5b58\u5272\u5408\u306f40%\u306832%\u3067\u3057\u305f\u3002<span style=\"color: #ff0000;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3057\u305f\u307b\u3046\u304c\u518d\u71c3\u304c\u65e9\u307e\u308b\u3068\u3082\u89e3\u91c8\u3055\u308c\u307e\u3059<\/strong><\/span>\u3002\u3053\u306e\u5927\u304d\u306a\u7dda\u91cf\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067\u306fpseudoprogression\u304c\u751f\u3058\u3066\u3044\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<br \/>\nRizzo D, et al.: Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise? J Chemother 2014 Dec [Epub]<br \/>\n\u307e\u305f\u7e70\u308a\u8fd4\u3057\u306a\u306e\u3067\u3059\u304c\uff0c15\u4eba\u306e\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u306e\u5b50\u3069\u3082\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u6cbb\u7642\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u52b9\u679c\u306f\u7121\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4 align=\"left\">\u3073\u307e\u3093\u6027\u6a4b\u81a0\u816b\u306e\u5b50\u4f9b\u305f\u3061\u306e\u751f\u5b58\u306e\u4e88\u6e2c<\/h4>\n<p>Jansen MH, et al.: Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol 17:160-166, 2015<br \/>\n\u30e8\u30fc\u30ed\u30c3\u30d1\u3067316\u4eba\u306e\u60a3\u5150\u3092\u89e3\u6790\u3057\u305f\u5831\u544a\u3067\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f10\u30f6\u6708\u3067\u3057\u305f\u3002\u816b\u760d\u304c\u767a\u898b\u3055\u308c\u308b\u307e\u3067\u306e\u75c7\u72b6\u306e\u671f\u9593\u304c\u9577\u3044\uff0c\uff13\u6b73\u4ee5\u4e0b\uff0c\u5316\u5b66\u7642\u6cd5\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u6761\u4ef6\u3067\u751f\u5b58\u671f\u9593\u304c\u5c11\u3057\u9577\u3044\u305d\u3046\u3067\u3059\u3002\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u5264\u3067\u30ea\u30f3\u30b0\u72b6\u306b\u5897\u5f37\u3055\u308c\u308b\u816b\u760d\u306f\u4e88\u5f8c\u304c\u60aa\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d \u5316\u5b66\u7642\u6cd5\u304c\u4f7f\u7528\u3067\u304d\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3042\u308b\u7a0b\u5ea6\u72b6\u614b (PS) \u304c\u826f\u304b\u3063\u305f\u3053\u3068\u3067\u3082\u3042\u308a\u4f55\u3068\u3082\u8a00\u3048\u307e\u305b\u3093\u30022015\u5e74\u306e\u5927\u304d\u306a\u5831\u544a\u3067\u3059\u304c\uff0c\u3044\u307e\u307e\u3067\u8a00\u308f\u308c\u3066\u6765\u305f\u3053\u3068\u3068\u5909\u308f\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h4 align=\"left\">\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3068\u653e\u5c04\u7dda\u6cbb\u7642<\/h4>\n<p align=\"left\">Pollack IF, et al.: A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol 13:290-297, 2011<br \/>\n\u3073\u307e\u3093\u6027\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306e43\u4eba\u306e\u5b50\u3069\u3082\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b250 mg\/m(2)\/day\u306e\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u304c\u7d4c\u53e3\u6295\u4e0e\u3055\u308c\uff0c\u75c5\u52e2\u306e\u9032\u884c\u304c\u306a\u3044\u9650\u308a13\u30f6\u6708\u7d99\u7d9a\u3055\u308c\u307e\u3057\u305f\u300212\u30f6\u6708\u306824\u30f6\u6708\u306e\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408 PFS\u306f\uff0c20.9%\u30689.3%\u3067\u3057\u305f\u3002\u5168\u751f\u5b58\u5272\u5408 OS\u306f\uff0c56.4%\u306819.6%\u3067\u3059\u30023\u4eba\u306e\u5b50\u3069\u3082\u304c3\u5e74\u3092\u8d8a\u3048\u3066\u751f\u5b58\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u751f\u5b58\u5272\u5408\u306f\u3068\u3066\u3082\u826f\u3044\u6210\u7e3e\u3067\u3059\u3002\u3057\u304b\u3057\uff0c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u816b\u760d\u304cdiffuse brainstem glioma\u3067\u3042\u3063\u305f\u3053\u3068\u306b\u6ce8\u610f\u304c\u5fc5\u7528\u3067\u3059\u3002diffuse pontine glioma\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u30023\u5e74\u4ee5\u4e0a\u9577\u671f\u751f\u5b58\u3057\u305f\u5b50\u3069\u3082\u3082\u75c5\u7406\u7d44\u7e54\u306f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3067\uff0c\u6a4b\u3068\u5ef6\u9ac4\u306e\u5883\u754c\u306b\u3067\u304d\u305f\u6bd4\u8f03\u7684\u9650\u5c40\u6027\u306e\u816b\u760d\u3067\u3057\u305f\u3002\u3073\u307e\u3093\u6027\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6210\u7e3e\u3068\u3073\u307e\u3093\u6027\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u6cbb\u7642\u6210\u7e3e\u306f\u7570\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u6ce8\u610f\u3057\u3066\u8ad6\u6587\u3092\u89e3\u91c8\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4>\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u00a0nimotuzumab<\/h4>\n<p>\u3053\u306e10\u5e74\u3067\uff0c\u60aa\u6027\u795e\u7d4c\u81a0\u816b\uff08\u30b0\u30ea\u30aa\u30fc\u30de\uff09\u304c\u6210\u9577\u3059\u308b\u305f\u3081\u306b\u5fc5\u7528\u3068\u3059\u308b\u5206\u5b50\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u53d7\u5bb9\u4f53\uff09\u304c\u305f\u304f\u3055\u3093\u77e5\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002 \u4eca\u307e\u3067\u306f\u5b9f\u9a13\u5ba4\u306e\u4e2d\u3067\u306e\u304a\u8a71\u3067\u3057\u305f\u304c\uff0c\u73fe\u5728\u3067\u306f\u305f\u304f\u3055\u3093\u306e\u85ac\uff08\u5316\u5b66\u7642\u6cd5\u5264\u3084\u6297\u4f53\uff09\u304c\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u81e8\u5e8a\u8a66\u9a13\u306e\u6bb5\u968e\u304b\u3089\u85ac\u5264\u3068\u3057\u3066 \u671f\u5f85\u3055\u308c\u3066\u304d\u3066\u3044\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u6b27\u7c73\u3067\u306e\u304a\u8a71\u3067\u3042\u308a\uff0c\u65e5\u672c\u3067\u306f\u6cbb\u9a13\u3082\u59cb\u307e\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305f\u3068\u3048\u3070\uff0cEGFR\u3068\u3044\u3046\u53d7\u5bb9\u4f53 (ErbB1) \u306e\u50cd\u304d\u3092\u6291\u3048\u308b<strong><span style=\"color: #000080;\">\u30cb\u30e2\u30c4\u30ba\u30de\u30d6\u00a0nimotuzumab<\/span><\/strong>\u3068\u3044\u3046\u6297\u4f53\u304c\uff0c\u6b27\u5dde\u3067\u306f\u5c0f\u5150\u60aa\u6027\u795e\u7d4c\u81a0\u816b\uff08\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\uff09\u306b\u671f\u5f85\u3092\u6301\u305f\u308c\u307e\u3057\u305f\u304c\u3042\u307e\u308a\u826f\u3044\u7d50\u679c\u306f\u51fa\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6b8b\u5ff5\u306a\u304c\u3089\u3044\u307e\u306e\u3068\u3053\u308d\uff0c\u56fd\u5916\u304b\u3089\u500b\u4eba\u8f38\u5165\u3057\u3066\u3067\u3082\u4f7f\u3063\u3066\u4e0b\u3055\u3044\u3068\u5f37\u304f\u304a\u52e7\u3081\u3067\u304d\u308b\u85ac\u5264\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u3068\u30a8\u30c8\u30dd\u30b7\u30c9\u5316\u5b66\u7642\u6cd5<\/h4>\n<p>Korones DN, et al.: Treatment of children with diffuse intrinsic brainstem glioma with radiotherapy, vincristine and oral VP-16: a Children&#8217;s Oncology Group phase II study. Pediatr Blood Cancer, 20: 227-230, 2008<br \/>\n\uff13\u6b73\u304b\u308914\u6b73\u307e\u3067\uff0c\u3073\u307e\u3093\u6027\u6a4b\u5185\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u306e30\u4eba\u304c\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u300254\u30b0\u30ec\u30a4\u3092\u4e0a\u9650\u3068\u3059\u308b\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u540c\u6642\u306b\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\u30921\u65e5\u76ee\uff0c\uff18 \u65e5\u76ee\uff0c15\u65e5\u76ee\u306b\u9759\u8108\u6ce8\u5c04\uff0c\u30a8\u30c8\u30dd\u30b7\u30c9\u3092\uff11\u65e5\u76ee\u304b\u308921\u65e5\u76ee\u307e\u3067\u7d9a\u3051\u3066\u670d\u7528\u3059\u308b\u5316\u5b66\u7642\u6cd5\u304c\uff12\u30b3\u30fc\u30b9\u884c\u306a\u308f\u308c\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u7d42\u308f\u3063\u3066\u304b\u3089\u306f10\u30b3\u30fc\u30b9 \u307e\u3067\u7d9a\u3051\u3089\u308c\u307e\u3057\u305f\u3002\uff17\u4eba\u306e\u60a3\u5150\u3067\u594f\u52b9(PR)\u3057\u3066\uff0c18\u4eba\u306e\u60a3\u5150\u3067\u306f\u4e0d\u5909(SD)\u3067\uff0c\uff12\u4eba\u3067\u306f\u9032\u884c(PD)\u3057\u307e\u3057\u305f\u3002\u7d50\u679c\u7684\u306b30\u4eba\u5168\u54e1\u304c\u547d\u3092\u5931\u3063 \u3066\uff0c\uff11\u5e74\u751f\u5b58\u5272\u5408\u306f27%\uff0c\uff12\u5e74\u751f\u5b58\u5272\u5408\u306f3%\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff19\u30f6\u6708\u3067\u3057\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\uff0c\u3053\u306e\u5316\u5b66\u7642\u6cd5\u306f\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3067\u304d\u306a\u3044\u3057\uff0c\u307e\u305f\u8840\u6db2\u6bd2 \u751f\u3084\u5614\u6c17\u3084\u611f\u67d3\u306a\u3069\u306e\u6709\u5bb3\u4e8b\u8c61\uff08\u526f\u4f5c\u7528\uff09\u304c\u751f\u3058\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u5316\u5b66\u7642\u6cd5\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u52a0\u3048\u3066\u3082\u526f\u4f5c\u7528\u304c\u3067\u308b\u306e\u307f\u3067\u4f55\u3082\u306a\u3089\u306a\u3044\u3068\u8a00\u3046\u3053\u3068\u304c\u307e\u305f\u78ba\u8a8d\u3055\u308c\u305f\u3068\u3044\u3046\u5370\u8c61\u3067\u3059\u3002<\/p>\n<h4><strong><span style=\"color: #ff0000;\">\u591a\u5264\u4f75\u7528\u5316\u5b66\u7642\u6cd5<\/span><\/strong>\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u524d\u306b\u3059\u308b<\/h4>\n<p>2005\u5e74\u306e\u56fd\u969b\u8133\u816b\u760d\u5b66\u4f1a\u3067\uff0c\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\uff0c\u30ed\u30e0\u30b9\u30c1\u30f3\uff0c\u30e1\u30c8\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\uff0c\u30cf\u30a4\u30c9\u30ed\u30ad\u30b7\u30a6\u30ec\u30a2\u306e\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u5316\u5b66\u7642\u6cd5 \u3092\u5148\u306b\u884c\u3063\u3066\u304a\u3044\u3066\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u75c7\u72b6\u306e\u60aa\u5316\u306a\u3069\u306e\u6642\u306b\u4f7f\u308f\u308c\u307e\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u306f\u308f\u305a\u304b\u306b\u5ef6\u9577\u3059\u308b\u306e\u3067\u3059\u304c\uff0c\u816b\u760d\u304c\u6cbb\u308b\u7387\u306f\u5909\u308f\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u5316\u5b66\u7642 \u6cd5\u3092\u884c\u3046\u305f\u3081\u306b\u5165\u9662\u671f\u9593\u306e\u5ef6\u9577\u304c\u3042\u308a\uff0c\u3082\u3068\u3082\u3068\u975e\u5e38\u306b\u4e88\u5f8c\u304c\u77ed\u3044\u60a3\u5150\u304c\u81ea\u5b85\u306b\u5e30\u308b\u671f\u9593\u304c\u77ed\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4>\u305f\u3076\u3093\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u306f\u307e\u3060\u5f79\u306b\u7acb\u305f\u306a\u3044\u5206\u5b50\u751f\u7269\u5b66\u306e\u77e5\u898b<\/h4>\n<h5>H3F3A.3 K27M mutation in 71%<\/h5>\n<h5>p53 mutation in 40-77%<\/h5>\n<h5>PDGFR amp in 13-36%<\/h5>\n<h5>EGFR amp in 28%<\/h5>\n<\/div>\n<p>\u4e0b\u306e\u4e21\u8ad6\u6587\u306f2014\u5e74\u306b\uff0cNature\u306b\u767a\u8868\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u81e8\u5e8a\u7684\u306b\u5f79\u306b\u7acb\u3064\u30ec\u30d9\u30eb\u306e\u77e5\u898b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u65e5\u672c\u3067\u306f\uff0c\u7d44\u7e54\u8a3a\u65ad\u306f\u3067\u304d\u3066\u3082\u3053\u306e\u3088\u3046\u306a\u7814\u7a76\u306f\u3067\u304d\u307e\u305b\u3093\u306e\u3067\uff0c\u6b27\u7c73\u306b\u671f\u5f85\u3067\u3059\u3002\u57fa\u790e\u7814\u7a76\u306e\u30ec\u30d9\u30eb\u306f\u3053\u306e\u6bb5\u968e\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u8aad\u3093\u3067\u4e0b\u3055\u3044\u3002<br \/>\n<em>Buczkowicz P, et al.: Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.\u00a0Nat Genet 46: 451-456, 2014<\/em><br \/>\nDIPGs comprise three molecularly distinct subgroups (H3-K27M, silent and MYCN) and uncovering a new recurrent activating mutation affecting the activin receptor gene ACVR1 in 20% of DIPGs. Mutations in ACVR1 were constitutively activating, leading to SMAD phosphorylation and increased expression of the downstream activin signaling targets ID1 and ID2.<br \/>\n<em>Wu G, et al.: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 46:444-450, 2014<br \/>\n<\/em>We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to previously reported frequent somatic mutations in histone H3 genes, TP53 and ATRX, in both DIPGs and NBS-HGGs. Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40% of NBS-HGGs in infants. Mutations targeting receptor tyrosine kinase-RAS-PI3K signaling, histone modification or chromatin remodeling, and cell cycle regulation were found in 68%, 73% and 59% of pediatric HGGs, respectively, including in DIPGs and NBS-HGGs.<\/p>\n<h4>\u816b\u760d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u7814\u7a76<\/h4>\n<p>Grill J, et al.: Clitical oncogenic mutation in newlyu diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer 58: 487-488, 2012<br \/>\n<span style=\"color: #000080;\"><strong>TP53 (40%), PI3KCA (15%), and ATM\/MPL (5%)<\/strong> <\/span>\u306b\u5909\u7570\u304c\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u30c6\u30f3\u30c8\u4e0a\u306e\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u3068\u306f\u7570\u306a\u3063\u305f\u907a\u4f1d\u5b50\u5909\u7570\u3067\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u767a\u751f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5f37\u304f\u793a\u5506\u3059\u308b\u7d50\u679c\u3067\u3059\u3002\u3064\u307e\u308a\u4e00\u822c\u7684\u306a\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306b\u6709\u52b9\u306a\u85ac\u5264\u304c\u52b9\u304b\u306a\u3044\u6050\u308c\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3082\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306e\u305f\u3081\u306b20\u4eba\u306e\u5b50\u4f9b\u305f\u3061\u304c\u5b9a\u4f4d\u751f\u691c\u8853\u3092\u53d7\u3051\u3066\u816b\u760d\u7d44\u7e54\u3092\u63a1\u53d6\u3055\u308c\u307e\u3057\u305f\u3002\u3067\u3082\uff0c\u3053\u306e\u5b50\u4f9b\u305f\u3061\u306b\u3068\u3063\u3066\u306f\u4f55\u306e\u5229\u76ca\u3082\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5c06\u6765\u306e\u7814\u7a76\u306e\u305f\u3081\u306b\u305d\u3093\u306a\u3053\u3068\u3092\u3057\u3066\u3044\u3044\u306e\u304b\u3069\u3046\u304b\u3000&gt; (;_;). &lt;<\/p>\n<h4>\u30e2\u30c6\u30ad\u30b5\u30d5\u30a3\u30f3\u30fb\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u3068\u653e\u5c04\u7dda\u6cbb\u7642<\/h4>\n<p>Bradley KA, et al.: Motexafin gadlinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children&#8217;s Oncology Group phase I study. Neuro Oncol 10: 752-758, 2008<br \/>\n44\u4eba\u306e\u6a4b\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u5150\u304c\uff0c54\u30b0\u30ec\u30a4\/30\u5206\u5272\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30e2\u30bf\u30ad\u30b5\u30d5\u30a3\u3093\u30fb\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0 (1.7-9.2mg\/kg daily)\u3067\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u526f\u4f5c\u7528\u306f\u30b0\u30ec\u30fc\u30c9\uff13\u304b\u3089\uff14\u306e\u9ad8\u8840\u5727\u3068\u809d\u969c\u5bb3\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f313\u65e5\uff0810\u30f6\u6708\uff09\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u3053\u306e\u5831\u544a\u306f\u81e8\u5e8a\u7b2c\uff11\u76f8\u8a66\u9a13\u3068\u3044\u3063\u3066\u65b0\u3057\u3044\u85ac\u5264\u306e\u6709\u5bb3\u4e8b\u8c61\uff08\u526f\u4f5c\u7528\uff09\u3068\u4f7f\u7528\u91cf\u3092\u307f\u308b\u305f\u3081\u306e\u3082\u306e\u3067\u3059\u3002HIF1-alpha (hypoxia-inducible factor-1 alpha)\u3068\u3044\u3046\u7269\u8cea\u3092\u6291\u5236\u3059\u308bMotexafin\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u52b9\u679c\u3092\u4e0a\u3052\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u8003\u3048\u304b\u3089\u306e\u8a66\u9a13\u3067\u3059\u3002\u3067\u3082\u3042\u307e\u308a\u671f\u5f85\u3067\u304d\u306a\u3044\u3068\u601d\u308f\u308c \u307e\u3059\u3002<\/p>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree.jpg\" rel=\"attachment wp-att-8635\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-8635\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree-550x393.jpg\" alt=\"owlintree\" width=\"550\" height=\"393\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree-550x393.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree-300x215.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree-768x549.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlintree.jpg 931w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<h4>\u00a0\u6587\u732e<\/h4>\n<ol>\n<li><span class=\"highlight\">Aboian MS: Diffusion<\/span> <span class=\"highlight\">Characteristics<\/span> of <span class=\"highlight\">Pediatric<\/span> <span class=\"highlight\">Diffuse<\/span> <span class=\"highlight\">Midline<\/span> <span class=\"highlight\">Gliomas<\/span> with <span class=\"highlight\">Histone<\/span> H3-K27M Mutation Using Apparent <span class=\"highlight\">Diffusion<\/span> Coefficient Histogram Analysis. <span role=\"menubar\">AJNR Am J Neuroradiol.<\/span> 2019<\/li>\n<li>Albright AL, Packer RJ, Zimmerman R, et al. Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: A report from the Children\u2019s Cancer Group. Neurosurgery 33: 1026\u20131029, 1993<\/li>\n<li>Broniscer A, et al: Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98). Cancer 103:133-139, 2005<\/li>\n<li>Broniscer A, et al.: Young age may predict a better outcome for children with diffuse pontine glioma. Cancer 113: 566-572, 2008<\/li>\n<li>Cohen KJ, et al.: Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children&#8217;s Oncology Group. Neuro Oncol 13:410-416, 2011<\/li>\n<li>Grill J, et al.: Clitical oncogenic mutation in newlyu diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer 58: 487-488, 2012<\/li>\n<li><span class=\"highlight\">Hoffman LM, et al.: Clinical<\/span>, <span class=\"highlight\">Radiologic<\/span>, <span class=\"highlight\">Pathologic<\/span>, and <span class=\"highlight\">Molecular<\/span> <span class=\"highlight\">Characteristics<\/span> of <span class=\"highlight\">Long-Term<\/span> <span class=\"highlight\">Survivors<\/span> of <span class=\"highlight\">Diffuse<\/span>Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.\u00a0<span role=\"menubar\">J Clin Oncol.<\/span> 2018<\/li>\n<li>Jalali R , et al.: Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma. Int J Rad Oncol Biol Phys, 2009<\/li>\n<li>Jackson S , et al. Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. J Neurooncol 114: 339\u2013344. 2013<\/li>\n<li>Jansen MH, et al.: Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol 17:160-166, 2015<\/li>\n<li>Janssens GO, et al.: The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study. Int J Radiat Oncol Biol Phys (Epub) 2008<\/li>\n<li>Janssens GO, et al.:\u00a0Survival benefit for patients with\u00a0diffuse\u00a0intrinsic\u00a0pontine\u00a0glioma\u00a0(DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG\/DIPG working group. Eur J Cancer,\u00a02017<\/li>\n<li>Kieran MW: Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Pediatr Blood Cancer 62: 3-4, 2015<\/li>\n<li>Korones DN, et al.: Treatment of children with diffuse intrinsic brainstem glioma with radiotherapy, vincristine and oral VP-16: a Children&#8217;s Oncology Group phase II study. Pediatr Blood Cancer, 20: 227-230, 2008<\/li>\n<li>MacDonald TJ: Diffuse intrinsic pontine glioma (DIPG): Time to biopsy again?<\/li>\n<li>Warren KE: Diffuse intrinsic pontine glioma: poised for progress. Front Oncol 2: 205, 2012<\/li>\n<li>Pollack IF, et al.: A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol 13:290-297, 2011<\/li>\n<li>Rizzo D, et al.: Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise? J Chemother 2014<\/li>\n<li>Veldhuijzen van Zanten SE, et al.:\u00a0Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol.\u00a02017<\/li>\n<li>Zaghloul MS, et al.: Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial. Radiother Oncol. 2014 Feb 20<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8133\u5e79\u90e8\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u3044\u3046\u306e\u306f\u6b63\u78ba\u306a\u8a3a\u65ad\u540d\u3067\u306f\u3042\u308a\u307e\u305b\u3093 \u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u306f\uff0c\u3055\u307e\u3056\u307e\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059 \u8133\u5e79\u90e8\u306b\u306f\u3069\u3093\u306a\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3082\u3067\u304d\u307e\u3059\u3057\uff0c\u305d\u308c\u305e\u308c\u3067\u6cbb\u7642\u65b9\u6cd5\u304c\u7570\u306a\u308a\u307e\u3059 \u8133\u5e79\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u4e2d\u306e\u3044\u3063\u305f\u3044\u4f55\u3092\u4e88\u60f3\u3057\u3066\u3044\u308b\u306e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-160","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=160"}],"version-history":[{"count":131,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/160\/revisions"}],"predecessor-version":[{"id":23662,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/160\/revisions\/23662"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=160"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}