{"id":156,"date":"2012-04-17T23:33:30","date_gmt":"2012-04-17T14:33:30","guid":{"rendered":"\/sawamura\/wp\/?p=156"},"modified":"2025-01-28T13:01:16","modified_gmt":"2025-01-28T04:01:16","slug":"temozolo","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/temozolo\/","title":{"rendered":"\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\uff09temozolomide"},"content":{"rendered":"<div class=\"setumei\">\n<h5>2018\u5e74\u304b\u3089\u306f\uff0c3\u5272\u8ca0\u62c5\u306e\u60a3\u8005\u3055\u3093\u304c300mg\/\u65e5\u306e\u4f7f\u7528\u3067\uff0c\u6708\u306e\u85ac\u5264\u8cbb\u304c7\u4e075,000\u5186\u304b\u30893\u4e071,500\u5186\u307e\u3067\u4e0b\u304c\u308a\u307e\u3057\u305f (^o^)\u30ce<\/h5>\n<h5>\u5546\u54c1\u540d \u30c6\u30e2\u30c0\u30fc\u30eb\u00a0Temodal\uff08\u5148\u767a\uff09\uff0c\u30c6\u30e2\u30be\u30ed\u30df\u30c9 Temozolomide\uff08\u5f8c\u767a\uff0c\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff09<\/h5>\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u53e3\u304b\u3089\u98f2\u3080\u7d4c\u53e3\u5264\u3068\u3044\u3046\u5236\u304c\u3093\u5264\u3067\u30ab\u30d7\u30bb\u30eb<\/strong><\/span>\u306b\u5165\u3063\u3066\u3044\u307e\u3059\uff0c\u98f2\u3081\u306a\u3044\u60a3\u8005\u3055\u3093\u306b\u306f\u6ce8\u5c04\u3067\u3082\u6295\u4e0e\u3067\u304d\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u9069\u5fdc\u75c7\u306f\u60aa\u6027\u795e\u7d4c\u81a0\u816b<\/span><\/strong>\uff08<span style=\"color: #000080;\"><strong>\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\uff09\u3067\u3059<\/li>\n<li>\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e\u5b9a\u7fa9\u306f\u5e83\u3044\u3067\u3059\u3057\uff0c\u81a0\u82bd\u816b\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\uff0c\u9ac4\u82bd\u816b\uff0c\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306a\u3069\u3082\u542b\u307e\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6b27\u7c73\u3067\u306f\u81a0\u82bd\u816b\u3068\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3060\u3051\u306b\u8a8d\u53ef\u3055\u308c\u3066\u3044\u3066\uff0c\u305d\u308c\u3089\u306e\u816b\u760d\u306b\u306f\u6a19\u6e96\u7684\u6cbb\u7642\u85ac<\/strong><\/span>\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u4f8b\u3048\u3070\u81a0\u82bd\u816b\u306b\u306f\uff12\u3068\u304a\u308a\u306e\u65b9\u6cd5\u3067\u4f7f\u308f\u308c\u307e\u3059<\/li>\n<li>\u4e00\u3064\u76ee\u306f\u4e3b\u306b\u5165\u9662\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u671f\u9593\u4e2d\u306b\u7167\u5c04\u306e\u524d\u306e\u65e5\u306b\u6bce\u65e5\u98f2\u3080\u65b9\u6cd5\u3067\uff0c\uff11\u65e5\u306b\u4f53\u8868\u9762\u7a4d\u3042\u305f\u308a75mg (75mg\/m2)\u4f7f\u3044\u307e\u3059<\/li>\n<li>\uff12\u3064\u76ee\u306f\u4e3b\u306b\u5916\u6765\u3067\uff0c\u7dad\u6301\u7642\u6cd5\u3068\u3044\u3063\u306628\u65e5\uff084\u9031\u9593\uff09\u306b5\u65e5\u9593\u3060\u3051\u98f2\u3080\u65b9\u6cd5\u3067\uff0c\uff11\u65e5\u306b\u4f53\u8868\u9762\u7a4d\u3042\u305f\u308a100\u304b\u3089200mg (100-200mg\/m2)\u4f7f\u3044\u307e\u3059<\/li>\n<li>\u4ee3\u8868\u7684\u306a\u4f7f\u7528\u6cd5\u3067\uff0c\u3053\u308c\u3092Stupp regimen<span style=\"color: #000080;\"><strong> \u30b9\u30c4\u30c3\u30d7\u30ec\u30b8\u30e1\u30f3<\/strong><\/span>\u3068\u547c\u3073\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u7a7a\u8179\u6642\u306b\u98f2\u3080\u306e\u304c\u539f\u5247\u306a\u306e\u3067\uff0c\u304a\u8179\u3044\u3063\u3071\u3044\u306e\u6642\u306b\u306f\u98f2\u307e\u306a\u3044\u3088\u3046\u306b\u3057\u307e\u3057\u3087\u3046<\/strong><\/span><\/li>\n<li>\u60a3\u8005\u3055\u3093\u304c\u5143\u6c17\u3067\u3042\u308c\u3070\u50cd\u304d\u306a\u304c\u3089\u98f2\u3093\u3067\u884c\u304f\u3053\u3068\u3082\u3067\u304d\u307e\u3059<\/li>\n<li>\u7dad\u6301\u7642\u6cd5\u306f\u3060\u3044\u305f\u3044\u6708\u306b\uff11\u56de\u3067\uff16\u30f6\u6708\u3068\u304b\uff12\u5e74\u9593\u3068\u304b\u7d9a\u3051\u308b\u65b9\u6cd5\u3067\u3059<\/li>\n<li>\u6709\u52b9\u6027\u306f\u5f8c\u308d\u306e\u65b9\u306b\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u306e\u3067\u8aad\u3093\u3067\u4e0b\u3055\u3044<\/li>\n<li>\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u306f\u5168\u822c\u7684\u306b\u3068\u3066\u3082\u8efd\u3044\u3068\u8a55\u4fa1\u3057\u3066\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u8efd\u3044\u9aa8\u9ac4\u6291\u5236\uff08\u767d\u8840\u7403\u3084\u8840\u5c0f\u677f\u306e\u6e1b\u5c11\uff09\uff0c\u5410\u304d\u6c17\u3068\u5614\u5410\uff0c\u4fbf\u79d8\uff0c\u982d\u75db\uff0c\u4f53\u306e\u3060\u308b\u3055\u3084\u982d\u75db<\/span><\/strong>\u306a\u3069\u3067\u3059<\/li>\n<li>\u5410\u304d\u6c17\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u98f2\u3080\u524d\u306b\u5410\u304d\u6c17\u6b62\u3081\uff08\u30ca\u30bc\u30a2\uff0c\u30ab\u30a4\u30c8\u30ea\u30eb\uff0c\u30be\u30d5\u30e9\u30f3\u306a\u3069\uff09\u3092\u98f2\u3093\u3067\u304a\u304f\u3068\u6291\u3048\u3089\u308c\u307e\u3059<\/li>\n<li>\u767d\u8840\u7403\uff08\u597d\u4e2d\u7403\uff09\u306e\u6e1b\u5c11\u306f\u8840\u6db2\u691c\u67fb\u3067\u898b\u3066\u884c\u304d\u307e\u3059\u304c\uff0c\u3042\u307e\u308a\u5f37\u304f\u3067\u308b\u3068\u611f\u67d3\u75c7\u3084\u51fa\u8840\u306e\u5371\u967a\u304c\u3042\u308b\u3082\u306e\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u30ea\u30f3\u30d1\u7403\u6e1b\u5c11<\/span><\/strong><span style=\"color: #333333;\">\u3068\u3044\u3046\u306e\u306b\u7279\u306b\u6ce8\u610f\u3057\u305f\u65b9\u304c\u3044\u3044\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #333333;\">\u9aa8\u9ac4\u6291\u5236\u306e\u5f37\u3044\u3068\u304d\u306b\u306f<\/span><strong><span style=\"color: #ff0000;\">\u9593\u8cea\u6027\u80ba\u708e<\/span><\/strong>\u3084<strong><span style=\"color: #ff0000;\">\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c6\u30a3\u30b9\u30fb\u30a4\u30ed\u30f4\u30a7\u30c1\u80ba\u708e<\/span><\/strong><span style=\"color: #333333;\">\uff08\u30ab\u30ea\u30cb\u80ba\u708e\u3068\u306f\u3044\u3044\u307e\u305b\u3093\uff09\u3068\u3044\u3046\u91cd\u7be4\u306a\u611f\u67d3\u75c7\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u4e88\u9632\u7684\u306b\u6297\u83cc\u5264\uff08\u30d0\u30af\u30bf\uff0cST\u5408\u5264\uff09\u3092\u98f2\u3080\u304b\uff0c\u30d9\u30ca\u30f3\u30d0\u30c3\u30af\u30b9\u306e\u5438\u5165\u3092\u5b9a\u671f\u7684\u306b\u3057\u307e\u3059\uff0c\u305d\u308c\u3067\u3082\u3060\u3081\u306a\u3089\u30b5\u30e0\u30c1\u30ec\u30fc\u30eb\uff08\u30a2\u30c8\u30d0\u30b3\u30f3 1500mg\uff09\u3092\u670d\u7528\u3057\u307e\u3059<\/span><\/li>\n<li>\u3053\u306e\u80ba\u708e\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u6295\u4e0e\u3092\u305f\u304f\u3055\u3093\u53d7\u3051\u3066\u3044\u308b\u6642\uff0c\u30ea\u30f3\u30d1\u7403\u306e\u6570\u3084\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u305f\u6642\u306b\u6700\u3082\u6ce8\u610f\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">B\u578b\u809d\u708e\u304c\u60aa\u5316\uff08\u518d\u6d3b\u6027\u5316\uff09<\/span><\/strong>\u3057\u3066\u91cd\u75c7\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u809d\u708e\u30a6\u30a3\u30eb\u30b9\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u67fb\u3057\u3066\u304b\u3089\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u6295\u4e0e\u3092\u53d7\u3051\u307e\u3059<\/li>\n<li>\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u4f7f\u7528\u304c\u9577\u671f\u9593\u306b\u306a\u308b\u3068\u526f\u4f5c\u7528\u306f\u5f37\u304f\u306a\u3063\u3066\u304d\u307e\u3059\u304b\u3089\uff0c\u98f2\u3080\u91cf\u306e\u8abf\u6574\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059<\/li>\n<\/ul>\n<\/div>\n<div class=\"setumei\">\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u98f2\u307f\u304b\u305f<\/h4>\n<p>\u30c6\u30e2\u30c0\u30fc\u30eb\u306fpH 7.4\u4ee5\u4e0a\u306e\u30a2\u30eb\u30ab\u30ea\u6027\u306b\u306a\u308b\u3068\u52b9\u679c\u304c\u7121\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u85ac\u3067\u3059\u3002\u7a7a\u8179\u6642\u306f\u80c3\u306e\u4e2d\u306f\u5f37\u3044\u9178\u6027\u3067\u3059\u304c\uff0c\u80c3\u306e\u4e2d\u306b\u98df\u7269\u304c\u5165\u3063\u3066\u3044\u308b\u72b6\u614b\u3067\u3053\u306e\u85ac\u3092\u98f2\u3080\u3068\u85ac\u306e\u52b9\u679c\u304c\u843d\u3061\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c<strong><span style=\"color: #ff0000;\">\u7a7a\u8179\u6642\u306b\u98f2\u307e\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u85ac\u5264<\/span><\/strong>\u3067\u3059\u3002\u591c\u5bdd\u308b\u524d\u3060\u3068\u98f2\u307f\u3084\u3059\u3044\u3068\u601d\u3044\u307e\u3059\u3002<br \/>\n\u30ab\u30d7\u30bb\u30eb\u3092\u98f2\u3081\u306a\u3044\u5c0f\u5150\u306b\u306f\uff0c\u8131\u30ab\u30d7\u30bb\u30eb\u3068\u3044\u3063\u3066\u30ab\u30d7\u30bb\u30eb\u3092\u306f\u305a\u3057\u3066\u85ac\u3092\u53d6\u308a\u51fa\u3057\u3066\u98f2\u307e\u305b\u308b\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002\u3067\u3082\u3053\u308c\u306f\u6297\u304c\u3093\u5264\u306b\u89e6\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u306e\u3067\u5f53\u7136\u304a\u533b\u8005\u3055\u3093\u3068\u76f8\u8ac7\u3057\u3066\u3069\u3046\u3059\u308b\u304b\u6c7a\u3081\u307e\u3059\u3002\u3067\u3082\u305d\u308c\u3057\u304b\u65b9\u6cd5\u306e\u7121\u3044\u5c0f\u3055\u306a\u5b50\u3069\u3082\u3067\u306f\u5de5\u592b\u3057\u3066<strong><span style=\"color: #ff0000;\">\u8131\u30ab\u30d7\u30bb\u30eb<\/span><\/strong>\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u30ab\u30d7\u30bb\u30eb\u304b\u3089\u53d6\u308a\u51fa\u3057\u305f\u85ac\u306f\u30ea\u30f3\u30b4\u30b8\u30e5\u30fc\u30b9\uff08\u9178\u6027\uff09\u304b\u4f55\u304b\u306b\u6eb6\u304b\u3057\u3066\u98f2\u307e\u305b\u307e\u3059\u3002\u30dd\u30ab\u30ea\u30b9\u30a8\u30c3\u30c8\u306a\u3069\u3067\u3082\u3044\u3044\u3067\u3059\u304c\uff0c\u30a2\u30eb\u30ab\u30ea\u6027\u306e\u98f2\u6599\u306f\u907f\u3051\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u98f2\u3081\u306a\u3044\u5834\u5408\u306b\u306f\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u70b9\u6ef4\u9759\u6ce8\u85ac 100mg\u304c\u3042\u308a\u307e\u3059<\/h4>\n<p>\u6295\u4e0e\u91cf\u306a\u3069\u306f\u7d4c\u53e3\u85ac\u3068\u540c\u3058\u3067\u3059\u304c\uff0c90\u5206\u9593\u304b\u3051\u3066\u70b9\u6ef4\u3057\u307e\u3059\u3002\u85ac\u5264\u8cbb\u306f\u7d4c\u53e3\u85ac\u306e\uff13\u500d\u304f\u3089\u3044\u306b\u306a\u308a\u307e\u3059\u304b\u3089\u9ad8\u984d\u3067\u3059\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h4><span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u52b9\u679c\u3092\u660e\u78ba\u306b\u3057\u305f\u6b74\u53f2\u7684\u306a\u8ad6\u6587<\/strong><\/span><\/h4>\n<p>\u30ed\u30fc\u30b6\u30f3\u30cc\u306e\u7814\u7a76\u8005\u304b\u3089\u306e\u767a\u8868\u3067\u3059\u3002New England Journal of Medicine\u3068\u3044\u3046\u3068\u3066\u3082\u6a29\u5a01\u306e\u9ad8\u3044\u96d1\u8a8c\u306b\u81a0\u82bd\u816b\u3078\u306e\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u52b9\u679c\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<span style=\"color: #ff0000;\"><strong>Stupp R<\/strong><\/span>, et al. : Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005<br \/>\n<strong><span style=\"color: #ff0000;\">Hegi M,<\/span><\/strong> et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005<\/p>\n<p>\u30e8\u30fc\u30ed\u30c3\u30d1\u3068\u30ab\u30ca\u30c0\u3067\u884c\u308f\u308c\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3067\u3059\u3002573\u4eba\u306e\u60a3\u8005\u3055\u3093\u306f\u653e\u5c04\u7dda\u6cbb\u7642\uff0860\u30b0\u30ec\u30a4\uff09\u306e\u307f\u3068\u653e\u5c04\u7dda\u6cbb\u7642\uff0860\u30b0\u30ec\u30a4\uff09\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3059\u308b\u7fa4\u306b\u632f\u308a\u5206\u3051\u3089\u308c\u3066\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u307e\u305a75mg\/m2\u306e\u91cf\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u306b\u6bce\u65e5\u98f2\u3080\u3068\u3044\u3046\u65b9\u6cd5\u3067\u6295\u4e0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304b\u3089150-200mg\/m2\uff085\u65e5\u9593\u670d\u7528\uff0c28\u65e5\u5468\u671f\uff09\u30921\u30b3\u30fc\u30b9\u3068\u3057\u30666\u30b3\u30fc\u30b9\u307e\u3067\u8ffd\u52a0\u3057\u307e\u3059\u3002<br \/>\n\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502428\u30f6\u6708\u306e\u6642\u70b9\u3067\u306e\u5168\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u7fa4\u304c12.1\u30f6\u6708\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3066\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u7fa4\u3067\u306f14.6\u30f6\u6708\u3067\u3057\u305f\u3002\u3061\u3087\u3063\u3068\u5bc2\u3057\u3044\u306e\u3067\u3059\u304c\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3059\u308b\u30682.5\u30f6\u6708\u306e\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u653e\u5c04\u7dda\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u7fa4\u3067\u306e\uff12\u5e74\u751f\u5b58\u5272\u5408\u306f26.5%\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u7fa4\u3067\u306f10.4%\u3067\u3057\u305f\u3002<br \/>\n\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f7%\u306e\u60a3\u8005\u3055\u3093\u306b\u30b0\u30ec\u30fc\u30c93-4\u306e\u8840\u6db2\u6bd2\u6027\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u308c\u306f\u3068\u3066\u3082\u8efd\u3044\u3082\u306e\u3068\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002<br \/>\n\u81a0\u82bd\u816b\u306e\u816b\u760d\u7d30\u80de\u306e\u4e2d\u306bMGMT\u3068\u3044\u3046\u907a\u4f1d\u5b50\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306f\u5316\u5b66\u7642\u6cd5\u306e\u52b9\u679c\u3092\u6d88\u3057\u3066\u3057\u307e\u3046\u50cd\u304d\u3092\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002MGMT\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u90e8\u5206\u306b\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u81a0\u82bd\u816b\u3092\u3082\u3064\u60a3\u8005\u3055\u3093\u306e\u65b9\u304c\u751f\u547d\u4e88\u5f8c\u304c\u3088\u3044\u3053\u3068\u304c\u5224\u308a\u307e\u3057\u305f\u3002\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u81a0\u82bd\u816b\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u3063\u305f\u6cbb\u7642\u3092\u3059\u308b\u3068\uff0c\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f21.7\u30f6\u6708\u3067\u3042\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u30e1\u30c1\u30eb\u5316\u304c\u306a\u3044\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u8ffd\u52a0\u3057\u3066\u3082\u306f\u3063\u304d\u308a\u3057\u305f\u52b9\u679c\u304c\u306a\u3044\u3088\u3046\u3067\u3042\u308b\u3068\u3082\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e8b\u5b9f\u306f\uff0c\u30e1\u30c1\u30eb\u5316\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u6295\u4e0e\u3057\u305f\u65b9\u304c\u826f\u3044\u304b\u3069\u3046\u304b\u304c\u3042\u3089\u304b\u3058\u3081\u5224\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3053\u306e\uff12\u3064\u306e\u8ad6\u6587\u306f\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\u3068\uff14\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d\uff08\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b\uff09\u306b\u5bfe\u3057\u3066\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u304c\u4e16\u754c\u7684\u306a\u6a19\u6e96\u7684\u6cbb\u7642\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u3044\u3046\u30a4\u30f3\u30d1\u30af\u30c8\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002\u3082\u3061\u308d\u3093\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u670d\u7528\u3067\u5f97\u3089\u308c\u308b\u52b9\u679c\u306f\u5927\u304d\u306a\u3082\u306e\u3067\u306f\u306a\u304f\u3066\uff0c\u3053\u306e\uff12\u3064\u306e\u816b\u760d\u578b\u306e\u6b7b\u4ea1\u7387\u304c\u3068\u3066\u3082\u9ad8\u3044\u3068\u3044\u3046\u4e8b\u5b9f\u3092\u8986\u3059\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\uff0c\u3053\u306e<span style=\"color: #ff0000;\"><strong>30\u5e74\u304f\u3089\u3044\u306e\u9593\u306b\u307b\u3068\u3093\u3069\u4f55\u306e\u9032\u6b69\u3082\u306a\u304b\u3063\u305f\u60aa\u6027\u661f\u7d30\u80de\u816b\u306e\u5316\u5b66\u7642\u6cd5\u306b\u5927\u304d\u306a\u8ee2\u6a5f\u3092\u3082\u305f\u3089\u3057\u305f\u81e8\u5e8a\u7814\u7a76<\/strong><\/span>\u306b\u306f\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002\u30e1\u30c1\u30eb\u5316\u304c\u3042\u308b\u304b\u306a\u3044\u304b\u3092\u8abf\u3079\u308b\u65b9\u6cd5\u306f\u96e3\u3057\u3044\u306e\u3067\uff0c\u4e00\u822c\u5316\u3055\u308c\u308b\u306e\u306f\u307e\u3060\u5c06\u6765\u306e\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h4><span style=\"color: #ff0000;\"><strong><a title=\"pseudoprogression\" href=\"\/sawamura\/braintumors\/pseudoprogression\/\">\u30c6\u30e2\u30c0\u30fc\u30eb\u3067\u751f\u3058\u308b<\/a><\/strong><\/span><span style=\"color: #ff0000;\"><strong><a title=\"pseudoprogression\" href=\"\/sawamura\/braintumors\/pseudoprogression\/\"><span style=\"color: #ff0000;\">\u30b9\u30fc\u30c9\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30e7\u30f3<\/span><\/a><\/strong><\/span><span style=\"color: #ff0000;\"><strong><a title=\"pseudoprogression\" href=\"\/sawamura\/braintumors\/pseudoprogression\/\">\uff08\u8a73\u7d30\u306f\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/strong><\/span><\/h4>\n<ul>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u4e00\u7dd2\u306b\u4f7f\u3046\u3068\u30b9\u30fc\u30c9\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30e7\u30f3\u3068\u3044\u3046\u73fe\u8c61\u304c\u751f\u3058\u307e\u3059<\/li>\n<li>MRI\u691c\u67fb\u3067\u4e00\u898b\uff0c\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u69d8\u306b\u307f\u3048\u308b\u306e\u3067\u3059\u304c\uff0c\u5b9f\u306f\u816b\u760d\u518d\u767a\uff08\u65e9\u671f\u518d\u71c3\uff09\u3067\u306f\u306a\u3044\u306e\u3067\u3059<\/li>\n<li>\u9006\u8aac\u7684\u3067\u3059\u304c\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u304c\u6709\u52b9\u306a\u4f8b\u306b\u8a8d\u3081\u3089\u308c\u308b\u3082\u306e\u3067\u3059<\/li>\n<\/ul>\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u3068\u611f\u67d3\u75c7<\/h4>\n<ul>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067\u751f\u3058\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u6700\u3082\u6709\u540d\u306a\u306e\u304c<strong><span style=\"color: #ff0000;\">\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c1\u30b9\u30fb\u30a4\u30ed\u30f4\u30a7\u30c1\u80ba\u708e<\/span><\/strong>\u3067\u3059<\/li>\n<li>\u3053\u306e\u80ba\u708e\u306e\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u306e\u3067\u4e88\u9632\u7684\u306b\u6297\u83cc\u5264\uff08<span style=\"color: #ff0000;\"><strong>\u30d0\u30af\u30bf<\/strong><\/span>\uff09\u3092\u670d\u7528\u3057\u307e\u3059<\/li>\n<li>\u3053\u308c\u3068\u306f\u5225\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\uff0c\u30ea\u30f3\u30d1\u7403\u306e\u6570\u3092\u6e1b\u3089\u3057\u305f\u308a\u30ea\u30f3\u30d1\u7403\u306e\u6d3b\u6027\uff08\u6a5f\u80fd\uff09\u3092\u6291\u3048\u305f\u308a\u3057\u307e\u3059<\/li>\n<li>\u30ea\u30f3\u30d1\u7403\u306f\u30a6\u30a3\u30eb\u30b9\u304b\u3089\u4f53\u3092\u5b88\u308b\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u306f\u30a6\u30a3\u30eb\u30b9\u6027\u75be\u60a3\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u4f8b\u3048\u3070B\u578b\u809d\u708e\u30a6\u30a3\u30eb\u30b9\u3092\u3082\u3063\u3066\u3044\u308b\u4eba\uff08\u4e0d\u9855\u6027\u611f\u67d3\u8005\u3068B\u578b\u809d\u708e\u306e\u5f8c\u3067\u6cbb\u3063\u305f\u4eba\uff09\u3067\u306f\uff0cB\u578b\u809d\u708e\u304c\u60aa\u5316\uff08\u518d\u71c3\uff09\u3057\u3066\u91cd\u75c7\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u98f2\u3080\u524d\u306b<strong><span style=\"color: #ff0000;\">B\u578b\u809d\u708e\u30a6\u30a3\u30eb\u30b9<\/span><\/strong>\u3092\u3082\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306e\u8840\u6db2\u691c\u67fb (HBs\u6297\u539f\u3001HBc\u6297\u4f53\u3001HBs\u6297\u4f53) \u3092\u3057\u307e\u3059<\/li>\n<li>\u611f\u67d3\u8005\u3067\u306f\u3053\u308c\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b<strong><span style=\"color: #ff0000;\">\u30d0\u30e9\u30af\u30eb\u30fc\u30c9<\/span><\/strong>\uff08\u6838\u9178\u7cfb\u9006\u8ee2\u5199\u9175\u7d20\u963b\u5bb3\u85ac\u30a8\u30f3\u30c6\u30ab\u30d3\u30eb\uff09\u3092\u98f2\u3093\u3060\u307b\u3046\u304c\u3044\u3044\u3067\u3059\u3002<\/li>\n<\/ul>\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u6669\u671f\u6709\u5bb3\u4e8b\u8c61<\/h4>\n<ul>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3068\u547c\u3070\u308c\u308b\u4ef2\u9593\u306e\u5236\u304c\u3093\u5264\u3067\u3059<\/li>\n<li>\u907a\u4f1d\u5b50\u306b\u4f5c\u7528\u3059\u308b\u85ac\u3067\u3059\u304b\u3089\u305d\u308c\u81ea\u4f53\u3067\u767a\u304c\u3093\u6027\u3092\u3082\u3063\u3066\u3044\u307e\u3059<\/li>\n<li>\u5bb9\u91cf\u4f9d\u5b58\u6027\u306b\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u306e\u3067\uff0c\u9577\u671f\u6295\u4e0e\u3067\u7279\u306b\u554f\u984c\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u9577\u671f\u6295\u4e0e\u304c\u3069\u306e\u304f\u3089\u3044\u306e\u671f\u9593\u304b\u306f\u306f\u3063\u304d\u308a\u3057\u307e\u305b\u3093\uff0c2\u5e74\u4ee5\u4e0a\u3068\u3044\u3046\u76ee\u5b89\u3082\u3042\u308b\u3088\u3046\u3067\u3059<\/li>\n<li>\u305d\u306e\u305f\u3081\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u670d\u7528\u3057\u3066\u6570\u30f6\u6708\u304b\u3089\u6570\u5e74\u5f8c\u306b,\uff0c<span style=\"color: #333333;\"><span style=\"color: #000080;\"><strong>\u6025\u6027\u767d\u8840\u75c5 treatment-related acute leukemia<\/strong><\/span>\u3084<strong><span style=\"color: #000080;\">non-Hodgikin lymphoma<\/span> \u306b<\/strong><\/span>\u306a\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u307b\u3093\u3068\u306e\u767d\u8840\u75c5\u306b\u306a\u308b\u524d\u306b\u306f<strong><span style=\"color: #ff0000;\">\u9aa8\u9ac4\u7570\u5f62\u6210 myelodysplasia<\/span><\/strong>\u3068\u3044\u3046\u72b6\u614b\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u3053\u308c\u306f\u8840\u6db2\u691c\u67fb\u3092\u3059\u308b\u3068\u7570\u5e38\u5024\u304c\u51fa\u308b\u306e\u3067\u767a\u898b\u3067\u304d\u307e\u3059<\/li>\n<li>\u3068\u3066\u3082\u7a00\u3067\u3059\u3057\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u670d\u7528\u3057\u306a\u3044\u3068\u6cbb\u3089\u306a\u3044\u795e\u7d4c\u81a0\u816b\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u3042\u308b\u306e\u3067\u3059\u304b\u3089\uff0c\u3053\u306e\u78ba\u7387\u304c\u4f4e\u3044\u5c06\u6765\u306e\u5fc3\u914d\u3092\u3057\u306a\u3044\u65b9\u304c\u3044\u3044\u3067\u3059<\/li>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\uff12\u5e74\u4ee5\u4e0a\u6295\u4e0e\u3059\u308b\u3068<span style=\"color: #000080;\"><strong>1%\u304f\u3089\u3044\u306e\u60a3\u8005\u3055\u3093\u3067\u767d\u8840\u75c5\u306a\u3069\u306e\u4e8c\u6b21\u764c<\/strong><\/span>\u304c\u767a\u751f\u3059\u308b\u3068\u3082\u8a00\u308f\u308c\u307e\u3059<\/li>\n<\/ul>\n<h5>\u6cbb\u308b\u53ef\u80fd\u6027\u306e\u9ad8\u3044\u5c0f\u5150\u306e\u8133\u816b\u760d\u3067\u306f\uff0c\u9577\u671f\u6295\u4e0e\u306f\u907f\u3051\u3066\u4e0b\u3055\u3044<\/h5>\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u5024\u6bb5<\/h4>\n<ul>\n<li>20mg\u304c\uff11\u30ab\u30d7\u30bb\u30eb\u30673,345\u5186\uff0c100mg\u304c\uff11\u30ab\u30d7\u30bb\u30eb\u306716,746\u5186\u3057\u307e\u3059<\/li>\n<li>\u4f53\u8868\u9762\u7a4d\u304c1.5m2\u306e\u6210\u4eba\u3067\u7dad\u6301\u7642\u6cd5\u306b\u4f7f\u3048\u3070\uff0c\uff11\u65e5\u3042\u305f\u308a300mg\u306b\u306a\u308a\u307e\u3059\u304b\u30895\u4e07\u5186\u304f\u3089\u3044\uff0c\u6708\u306b\uff15\u65e5\u9593\u98f2\u3080\u3068\u3057\u306625\u4e07\u5186\u3067\u3059<\/li>\n<li>\u533b\u7642\u8cbb\u304c\uff13\u5272\u8ca0\u62c5\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u85ac\u5264\u8cbb\u3060\u3051\u3067\u6708\u306b\uff17\u4e07\uff15\u5343\u5186\u306e\u81ea\u5df1\u8ca0\u62c5\u304c\u304b\u304b\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u305d\u306e\u4ed6\u306b\u53d7\u8a3a\u8cbb\u7528\u3068\u304b\u691c\u67fb\u6599\u91d1\u3068\u304b\u4ed6\u306e\u85ac\u4ee3\u304c\u52a0\u7b97\u3055\u308c\u3066\u304d\u307e\u3059<\/li>\n<li>\u9ad8\u984d\u533b\u7642\u5236\u5ea6\u3068\u3044\u3046\u306e\u304c\u3042\u3063\u3066\u6708\u306b\u3042\u308b\u7a0b\u5ea6\u984d\u4ee5\u4e0a\u306e\u533b\u7642\u8cbb\u306e\u81ea\u5df1\u8ca0\u62c5\u304c\u751f\u3058\u305f\u5834\u5408\u306b\u306f\u60a3\u8005\u3055\u3093\u306e\u81ea\u5df1\u8ca0\u62c5\u304c\u8efd\u6e1b\u3055\u308c\u307e\u3059\u304b\u3089\uff0c\u624b\u8853\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u308b\u5165\u9662\u4e2d\u306f\u9ad8\u984d\u533b\u7642\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3053\u306e\u5024\u6bb5\u306f\u3042\u307e\u308a\u6c17\u306b\u3057\u306a\u304f\u3066\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<li>\u554f\u984c\u306f\u9000\u9662\u3057\u3066\u304b\u3089\u5916\u6765\u3067\u7dad\u6301\u7642\u6cd5\u3092\u53d7\u3051\u308b\u3053\u3068\u3092\u52e7\u3081\u3089\u308c\u305f\u3068\u304d\u306e\u6bce\u6708\u306e\u81ea\u5df1\u8ca0\u62c5\u984d\u3067\u3059<\/li>\n<li>\u5e78\u30442017\u5e74\u306b\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\uff08\u3066\u30e2\u30be\u30ed\u30df\u30c9\uff09\u304c\u767a\u58f2\u3055\u308c\u3066\uff0c\u5024\u6bb5\u306f\u534a\u984d\u306b\u306a\u308a\u307e\u3057\u305f\uff0c\u305d\u308c\u3067\u3082\u9ad8\u984d\u533b\u7642\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304b\u3089\uff0c\u533b\u7642\u8cbb\u8acb\u6c42\u984d\u3092\u3057\u3063\u304b\u308a\u898b\u3066\u304f\u3060\u3055\u3044<\/li>\n<\/ul>\n<h4>\u611f\u67d3\u75c7\u3092\u751f\u3058\u306a\u3044\u305f\u3081\u306e\u5927\u5207\u306a\u3053\u3068<\/h4>\n<ul>\n<li>\u767d\u8840\u7403\u306e\u306a\u304b\u306b\u597d\u4e2d\u7403 neutrophil\u3068\u3044\u3046\u7d30\u80de\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u597d\u4e2d\u7403\u6570 <span style=\"color: #000080;\">(<strong>ANC<\/strong><\/span> absolute neutrophil count) \u306e\u6570\u304c1,500\/ml\u4ee5\u4e0a\u3067\u3042\u308c\u3070\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u3092200mg\/m2\u3067\u670d\u7528\u3067\u304d\u307e\u3059<\/li>\n<li>\u305d\u308c\u4ee5\u4e0b\u3060\u306850mg\u6e1b\u91cf\u3057\u307e\u3059<\/li>\n<li>\u5f90\u3005\u306b\u6e1b\u3089\u3057\u3066\u3044\u3063\u3066100mg\/2\u4ee5\u4e0b\u306b\u6e1b\u91cf\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3088\u3046\u306aANC\u306e\u5024\u306b\u306a\u308c\u3070\u4e2d\u6b62\u3057\u307e\u3059<\/li>\n<li>ANC\u304c\u4e0b\u304c\u308a\u3059\u304e\u308b\u3068\u91cd\u75c7\u611f\u67d3\u75c7\u3092\u307e\u306d\u304f\u3053\u3068\u304c\u3042\u308b\u304b\u3089\u3067\u3059<\/li>\n<li>\u3082\u3063\u3068\u3082\u91cd\u75c7\u3068\u306a\u308b\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c1\u30b9\u80ba\u708e\u306f\uff0c\u767a\u71b1\uff0c\u60aa\u5bd2\uff0c\u547c\u5438\u56f0\u96e3\u306a\u3069\u306e\u75c7\u72b6\u3092\u3060\u3057\u307e\u3059\uff0c\u91cd\u3044\u98a8\u90aa\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u7591\u3044\u307e\u3059<\/li>\n<li>\u30cb\u30e5\u30fc\u30e2\u30b7\u30b9\u30c1\u30b9\u80ba\u708e\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u306f\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u670d\u7528\u4e2d\u306b<span style=\"color: #000080;\"><strong>\u30d0\u30af\u30bf<\/strong><\/span>\uff08\u30b9\u30eb\u30d5\u30a1\u30e1\u30c8\u30ad\u30b5\u30be\u30fc\u30eb\u30fb\u30c8\u30ea\u30e1\u30c8\u30d7\u30ea\u30e0 400mg\uff0cST\u5408\u5264\uff09\u30921\u65e51\u9320\u6bce\u65e5\u670d\u7528\u3057\u307e\u3059<\/li>\n<li>\u30d0\u30af\u30bf\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u3067\u98f2\u3081\u306a\u3044\u6642\u306b\u306f\uff0c<span style=\"color: #000080;\"><strong>\u30d9\u30ca\u30f3\u30d0\u30c3\u30af\u30b9<\/strong><\/span>\uff08\u30da\u30f3\u30bf\u30df\u30b8\u30f3\uff09\u306e\u5438\u5165\u3092\u3057\u307e\u3059<\/li>\n<li>\u30d9\u30ca\u30f3\u30d0\u30c3\u30af\u30b9\u306b\u3082\u30a2\u30ec\u30eb\u30ae\u30fc\u304c\u3042\u308b\u5834\u5408\u306b\u306f\uff0c<span style=\"color: #000080;\"><strong>\u30b5\u30e0\u30c1\u30ec\u30fc\u30eb<\/strong><\/span>\uff08\u30a2\u30c8\u30d0\u30b3\u30f3 1500mg\uff09\u30921\u65e51\u56de\u670d\u7528\u3057\u307e\u3059<\/li>\n<\/ul>\n<h4>\u5410\u304d\u6c17\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/h4>\n<ul>\n<li>\u60a3\u8005\u3055\u3093\u304c\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u98f2\u3093\u3067\u3044\u3066\u3082\u3063\u3068\u3082\u3064\u3089\u3044\u306e\u306f\u5410\u304d\u6c17\u3067\u3059<\/li>\n<li>\u50ac\u5410\u6027\u30ea\u30b9\u30af\u5206\u985e\u3067\u306f\u4e2d\u7b49\u5ea6\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u5916\u6765\u6295\u4e0e\u3067\u306f\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u670d\u7528\u3059\u308b\u524d\u306b5-HT3\u53d7\u5bb9\u4f53\u62ee\u6297\u5264\uff0c<span style=\"color: #000080;\"><strong>\u30ca\u30bc\u30a2OD\u93200.1mg\uff08\u30e9\u30e2\u30bb\u30c8\u30ed\u30f3\uff09\uff0c\u30ab\u30a4\u30c8\u30ea\u30eb\u9320\uff12mg\uff08\u30b0\u30e9\u30cb\u30bb\u30c8\u30ed\u30f3\uff09\uff0c\u30be\u30d5\u30e9\u30f3\u93204mg\uff08\u30aa\u30f3\u30c0\u30f3\u30bb\u30c8\u30ed\u30f3\uff09<\/strong><\/span>\u306a\u3069\u3092\u98f2\u3093\u3067\u304a\u304f\u3068\u3060\u3044\u305f\u3044\u306e\u5410\u304d\u6c17\u306f\u6291\u3048\u3089\u308c\u307e\u3059<\/li>\n<li>\u305d\u308c\u3067\u3082\u3069\u3046\u3057\u3066\u3082\u5410\u304d\u6c17\u304c\u5f37\u3044\u6642\u306b\u306f\uff0c\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f38mg\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3057\u304b\u3057\uff0c\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f3\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u306a\u306e\u3067\u611f\u67d3\u306e\u30ea\u30b9\u30af\u306e\u7279\u5225\u9ad8\u3044\u60a3\u8005\u3055\u3093\u306b\u306f\u907f\u3051\u307e\u3059<\/li>\n<li>\u30a2\u30ed\u30ad\u30b70.75mg\uff08\u30d1\u30ed\u30ce\u30bb\u30c8\u30ed\u30f3\uff09\u9759\u6ce8\u3068\u30c7\u30ad\u30b5\u30e1\u30bf\u30be\u30f38mg\u30921\u65e5\u76ee\u306b\u4f7f\u7528\u3059\u308b\u3068\u3044\u3046\u65b9\u6cd5\u3082\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n<\/div>\n<h4>\u5c0f\u5150\u306e\u60aa\u6027\u30b0\u30ea\u30aa\u30fc\u30de\u3078\u306e\u52b9\u679c\u306b\u3064\u3044\u3066<\/h4>\n<p>\u5c0f\u5150\u306e\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306b\u306f\u6709\u52b9\u306a\u5236\u304c\u3093\u5264\u306f\u306a\u3044\u3068\u3044\u3063\u3066\u3082\u8a00\u3044\u904e\u304e\u3067\u306f\u306a\u3044\u6642\u4ee3\u304c\u7d9a\u304d\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u7b2c2\u4e16\u4ee3\u306e\u7d4c\u53e3\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3067\uff0c\u6210\u4eba\u306e<strong><a href=\"..\/braintumors\/astrocytictumor\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u81a0\u82bd\u816b<\/a><\/strong>\u306b\u5bfe\u3057\u3066\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304b\u3089\uff0c\u5c0f\u5150\u306e\u6cbb\u7642\u306b\u3082\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<br \/>\n\u6210\u4eba\u4f8b\u3067\u306f<strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/olig\/\">\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b<\/a><\/span><\/strong>\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u9ad8\u3044\u6709\u52b9\u6027\u304c\u5831\u544a\u3055\u308c\uff0cPCV\u5316\u5b66\u7642\u6cd5\u306b\u4ee3\u7528\u3057\u5f97\u308b\u85ac\u5264\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5c0f\u5150\u306b\u304a\u3044\u3066\u3082\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760d\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306b\u53cd\u5fdc\u3059\u308b\u795e\u7d4c\u81a0\u816b\u3067\u3042\u308b\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<br \/>\n\u5c0f\u5150\u306e\u6cbb\u7642\u62b5\u6297\u6027\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u3068<a href=\"..\/pediattumor\/brainstemglioma\/\">\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b<\/a>\u306b\u5bfe\u3059\u308b\u7b2c\uff12\u76f8\u8a66\u9a13\u304c\u6b27\u5dde\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002200mg\/m<sup>2<\/sup>\u3092\uff15\u65e5\u9593\u9023\u7d9a\u6295\u4e0e\u3057\u305f\u3082\u306e\u3067\u3059\u304c\uff0c\u767b\u9332\u3055\u308c\u305f55\u4f8b\u306b\u304a\u3044\u3066\u6709\u52b9\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u521d\u767a\u4f8b\u306e<a href=\"..\/pediattumor\/brainstemglioma\/\">\u3073\u307e\u3093\u6027\u8133\u5e79\u90e8\u81a0\u816b<\/a>29\u4f8b\uff08\u5e74\u9f62\u4e2d\u592e\u50246\u6b73\uff09\u306b\u5bfe\u3057\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306b\u540c\u69d8\u306a\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6295\u4e0e\u3092\u884c\u3063\u305f\u5831\u544a\u3067\u306f\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u502412\u30f6\u6708\u3067\u5168\u4f8b\u304c\u6b7b\u4ea1\u3057\u3066\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u8133\u5e79\u90e8\u795e\u7d4c\u81a0\u816b\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3068\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\u306e\u7b2c5\u9078\u629e\u80a2\u3068\u3057\u3066\uff0c\u518d\u767a\u80da\u7d30\u80de\u816b\u760d\uff0cPCNSL\uff08\u8133\u30ea\u30f3\u30d1\u816b\uff09\uff0c\u9ac4\u82bd\u816b\u30fb\u80ce\u5150\u6027\u816b\u760d\u306e\u7dad\u6301\u5316\u5b66\u7642\u6cd5\u306a\u3069\u3067\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u79d1\u5b66\u7684\u306a\u6839\u62e0\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u3057\uff0c\u3069\u306e\u3088\u3046\u306a\u5c0f\u5150\u8133\u816b\u760d\u306b\u6709\u52b9\u306a\u306e\u304b\u306f\u3053\u308c\u304b\u3089\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u5f85\u305f\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<div class=\"setumei\">\n<div>\n<div class=\"setumei\">\n<hr \/>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltemoz.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2721 size-medium\" title=\"owltemoz\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltemoz-240x300.jpg\" alt=\"\" width=\"240\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltemoz-240x300.jpg 240w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltemoz.jpg 550w\" sizes=\"auto, (max-width: 240px) 100vw, 240px\" \/><\/a><\/p>\n<\/div>\n<\/div>\n<h5 align=\"left\">\u6587\u732e<\/h5>\n<\/div>\n<h4>\u30b0\u30ec\u30fc\u30c9\uff12\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u65b9\u304c\u826f\u3044<\/h4>\n<p>Schiff D: LTBK-07. PROGRESSION-FREE AND OVERALL SURVIVAL RESULTS OF ECOG-ACRIN E3F05: A PHASE 3 INTERGROUP TRIAL OF RADIATION \u00b1 TEMOZOLOMIDE FOR GRADE II GLIOMAS. Neuro Oncol 2024<br \/>\n2024\u5e74\u672b\u306eSNO\u3067\u5831\u544a\u3055\u308c\u305f\u3068\u3066\u3082\u91cd\u8981\u306a\u767a\u8868\u3067\u3059\u3002\u81e8\u5e8a\u7b2c\uff13\u76f8\u7121\u4f5c\u70baE3FO5 trial\u306e\u7d99\u7d9a\u7d50\u679c\u3067\u3059\u3002172\u540d\u306e\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u3093\u3092\u6cbb\u7642\u5f8c\u306b10\u5e74\u4ee5\u4e0a\u7d4c\u904e\u89b3\u5bdf\u3057\u305f\u7d50\u679c\u3067\u3059\u3002\u521d\u671f\u6cbb\u7642\u3067\u653e\u5c04\u7dda\u6cbb\u764250.4Gy\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u3092\u884c\u306a\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\u306f10\u5e74\u751f\u5b58\u5272\u5408\u304c70\uff05\u306b\u5bfe\u3057\u3066\uff0c\u4f75\u7528\u3057\u306a\u304b\u3063\u305f\u7fa4\u3067\u306f47\uff05\u3067\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u304c\u30b0\u30ec\u30fc\u30c92\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u8cb4\u91cd\u306a\u5831\u544a\u3067\u3059\u3002\u3082\u3061\u308d\u3093\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u5bb3\u4e8b\u8c61\u3084\u7d4c\u6e08\u7684\u8eab\u4f53\u7684\u306a\u8ca0\u62c5\u306f\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u751f\u5b58\u5272\u5408\u306e\u5dee\u306f\u3068\u3066\u3082\u5927\u304d\u306a\u3082\u306e\u3067\u3059\u3002<br \/>\nDr Schiff\u306f\u91cd\u8981\u306a\u7d50\u679c\u3092\u542b\u3080\u3068\u7d9a\u3051\u307e\u3059\u3002\u306a\u3093\u3068\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u661f\u7d30\u80de\u816b\u3067\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002\u666e\u901a\u306f\u3069\u3046\u8003\u3048\u3066\u3082\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u65b9\u304c\u306f\u308b\u304b\u306b\u826f\u3044\u6210\u7e3e\u306e\u306f\u305a\u3067\u3059\u304c\uff1f<\/p>\n<h4>\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u30fb\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u65b9\u304c\u6709\u5bb3\u4e8b\u8c61\u304c\u5f37\u3044\u306e\u3067\u30c6\u30e2\u30c0\u30fc\u30eb\uff08\u5148\u767a\uff09\u3092\u4f7f\u7528\u3057\u305f\u65b9\u304c\u826f\u3044\u304b\u3082\uff1f<\/h4>\n<p>Omene E: Switch to generic formulation of temozolomide results in statistically significant increase in grade 3 and 4 bone marrow toxicity in glioma patients in the province of Alberta. Neuro-Oncology Practice 2024<br \/>\n\u30ab\u30ca\u30c0\u306e\u30a2\u30eb\u30d0\u30fc\u30bf\u5dde\u3067\u5148\u767a\u3068\u5f8c\u767a\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u52b9\u679c\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002\u816b\u760d\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306f\u30c6\u30e2\u30c0\u30fc\u30eb\uff08\u5148\u767a\u54c1\uff09\u304c\u5c11\u3057\u52dd\u308a\u307e\u3057\u305f\u304c\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u9aa8\u9ac4\u6291\u5236\u306f\u5f8c\u767a\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u88fd\u54c1\u306e\u65b9\u304c\u5f37\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<br \/>\n\u300e\u6ce8\u610f\u300f\u65e5\u672c\u306b\u3082\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u88fd\u54c1\u306f\u3042\u308a\u307e\u3059\u304c\uff0c\u3053\u306e\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u305f\u3082\u306e\u3068\u306f\u307e\u305f\u9055\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u81a0\u82bd\u816b\u3067\u306f\uff0c\uff16\u30b3\u30fc\u30b9\u4ee5\u4e0a\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u306b\u6709\u52b9\u6027\u306f\u306a\u3044<\/h4>\n<p>Balana, C: A phase II randomized, multicenter, open-label trial of continuing adjuvant temozolomide beyond six cycles in pati ents with glioblastoma (GEINO 14-01). Neuro Oncol 2020<br \/>\n\u81a0\u82bd\u816b 159\u4f8b\u3067\u7121\u4f5c\u70ba\u8a66\u9a13\u3055\u308c\u307e\u3057\u305f\u3002temozolomide\u3092\uff16\u30b3\u30fc\u30b9\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3066\u3082\uff0cPFS\u3068OS\u306b\u5ef6\u9577\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\u304c\u307e\u3059\u3060\u3051\u306a\u306e\u30676\u30b3\u30fc\u30b9\u3067\u6b62\u3081\u308b\u3079\u304d\u3068\u306e\u7d50\u8ad6\u3067\u3059\u3002<\/p>\n<\/div>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\uff0cIDH\u5909\u7570\u306e\u3042\u308b\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306bhypermutaiton \u904e\u5909\u7570\u3092\u8a98\u5c0e\u3059\u308b<\/h4>\n<p>ASCO 2020\u3067\u306eGralnis E\u3089\u306e\u767a\u8868\u3067\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067low grade IDH mutant glioma\u3092\u6cbb\u7642\u3059\u308b\u3068\uff0c57%\u3067hypermutation\u3092\u8a98\u5c0e\u3057\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002hypermutation\u306f\u816b\u760d\u306e\u60aa\u6027\u5ea6\u306b\u6bd4\u4f8b\u3057\u3066\u5897\u52a0\u3057\u307e\u3059\u3002high risk low grade glioma\u3078\u306e\u624b\u8853\u5f8c\u306e\u6a19\u6e96\u6cbb\u7642\u306f\uff0c\u653e\u5c04\u7dda\u3068PCV\u3067\u3042\u308a\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u4ee3\u7528\u3067\u304d\u306a\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3067\u3082\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b diffuse astrocytoma grade II\u306bPCV\u304c\u6709\u52b9\u3067\u3042\u3063\u305f\u3053\u3068\u306f\u8a3c\u660e\u3055\u308c\u305f\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3089\uff0clow grade glioma\u3068\u4e00\u3064\u62ec\u308a\u306b\u3059\u308b\u7d50\u8ad6\u306f\u53d7\u3051\u5165\u308c\u3089\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3059\u308b\u3068\u816b\u760d\u7d30\u80de\u306e\u904e\u5909\u7570\u304c\u751f\u3058\u308b<\/h4>\n<p><span style=\"color: #333333; font-family: minmoji; font-size: 16.00160026550293px;\">Tauat M: Mechanisms and therapeutic implications of hypermutation in gliomas. Nature 2020<br \/>\n<\/span>\u816b\u760d\u7d30\u80deDNA\u306e\u5909\u7570\u306e\u591a\u3055 mutational burden\u306f\uff0c\u816b\u760d\u306e\u60aa\u6027\u5ea6\u306b\u3082\u6bd4\u4f8b\u3057\u307e\u3059\u300210,294\u4f8b\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u907a\u4f1d\u5b50\u5909\u7570\u306e\u591a\u3055 hypermutation \u3092\u751f\u3058\u308b\u539f\u56e0\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002DNA polymelase\u3068mismatich repair (MMR) \u907a\u4f1d\u5b50\u306e\u6b20\u640d\u304c\u4e00\u3064\u306e\u539f\u56e0\u3067\u3059\u3002\u3082\u3046\u4e00\u3064\u306f\uff0c\u6cbb\u7642\u5f8c\u306eMMR\u6b20\u640d\u3067\u3059\u3002\u816b\u760d\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067\u6cbb\u7642\u3055\u308c\uff0c\u304b\u3064\u5316\u5b66\u7642\u6cd5\u306a\u6709\u52b9\u3067\u3042\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\uff0c\u3053\u306eMMR\u907a\u4f1d\u5b50\u306e\u6b20\u640d\u304c\u3042\u308a\u307e\u3057\u305f\u3002MMR\u6b20\u640d\u304c\u3042\u308b\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\uff0cT\u7d30\u80de\u6d78\u6f64\u304c\u5c11\u306a\u304f\u3066\uff0c\u816b\u760d\u7d30\u80de\u4e0d\u5747\u8cea\u304c\u9ad8\u304f\uff0c\u751f\u5b58\u671f\u9593\u304c\u77ed\u304f\uff0cPD-1\u963b\u5bb3\u5264\u3078\u306e\u53cd\u5fdc\u304c\u4f4e\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u5316\u5b66\u7642\u6cd5\u304c\u816b\u760d\u7d30\u80de\u306e\u904e\u5909\u7570\u3092\u8a98\u767a\u3059\u308b\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u306a\u306e\u3067\u816b\u760d\u7d30\u80de\u305d\u306e\u3082\u306e\u306eDNA\u5909\u7570\u304c\u5897\u3059\u3068\u3044\u3046\u3053\u3068\u306f\u4e88\u60f3\u3055\u308c\u308b\u3082\u306e\u3067\u3059\u3002\u514d\u75ab\u6cbb\u7642\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u306b\u6709\u52b9\u3068\u8a3c\u660e\u3055\u308c\u305f\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6297\u816b\u760d\u514d\u75ab\u80fd\u306e\u4f4e\u4e0b\u304c\u751f\u3058\u308b\u304b\u3089\u30b0\u30ea\u30aa\u30fc\u30de\u304c\u6cbb\u308a\u306b\u304f\u304f\u306a\u308b\u3068\u63a8\u6e2c speculation \u3059\u308b\u306e\u306f\u8a00\u3044\u904e\u304e\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4>\u30b0\u30ec\u30fc\u30c92\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3059\u308b\u3068\u60aa\u6027\u5316\u3059\u308b\uff1f<\/h4>\n<p><span class=\"highlight\">Choi S: Temozolomide<\/span>&#8211;<span class=\"highlight\">associated<\/span> <span class=\"highlight\">hypermutation<\/span> in <span class=\"highlight\">gliomas<\/span>.\u00a0<span role=\"menubar\">Neuro Oncol.<\/span> 2018<br \/>\n\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306f\uff0c\u30b0\u30ec\u30fc\u30c93\u306e\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3084\u30b0\u30ec\u30fc\u30c94\u306e\u81a0\u82bd\u816b\u3078\u3068\u5909\u308f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u58ca\u308c\u305f\u907a\u4f1d\u5b50\u3092\u4fee\u5fa9\u3059\u308b\u4f5c\u7528\u3092\u6291\u5236\u3059\u308b\u306e\u3067\uff0c\u907a\u4f1d\u5b50\u5909\u7570\u3092\u62db\u304d\u3084\u3059\u3044\u3068\u3044\u3046\u6b20\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067\u6cbb\u7642\u3055\u308c\u305fIDH mutant\u306e\u30b0\u30ec\u30fc\u30c92\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u304c\uff0c\u591a\u6570\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6709\u3059\u308b\u3088\u308a\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u30b0\u30ea\u30aa\u30fc\u30de hypermutated phenotype \u3078\u3068\u9032\u884c\u3059\u308b\u3068\u3044\u3046\u7591\u3044\u304c\u3082\u305f\u308c\u3066\u3044\u307e\u3059\u3002\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u78ba\u8a8d\u3057\u306a\u3044\u3067\u5b89\u6613\u306b\u30b0\u30ec\u30fc\u30c92 \u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u7528\u3057\u306a\u3044\u307b\u3046\u304c\u826f\u3044\u3068\u3044\u3046\u610f\u898b\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u30926\u30b3\u30fc\u30b9\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3066\u3082\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u306f\u5f97\u3089\u308c\u306a\u3044<\/h4>\n<p>Blumenthal D, Gorila T, Gilbert MR, et al. Is more better? The impact of extended adjuvant temozolomide in newly-diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology\/ RTOG. Neuro Oncol 2017<br \/>\n\u904e\u53bb\u306b\u884c\u308f\u308c\u305f\u5927\u898f\u6a21\u8a66\u9a13\u3067\u81a0\u82bd\u816b2214\u4f8b\u304c\u89e3\u6790\u3055\u308c\u307e\u3057\u305f\u30026\u30b3\u30fc\u30b9\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u306e\u6642\u70b9\u3067\u7121\u5897\u60aa\u3067\u3042\u3063\u305f624\u4f8b\u306e\u3046\u3061\uff0c291\u4f8b\u3067\u7dad\u6301\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u7d99\u7d9a\u3055\u3048\u308c\uff0c333\u4f8b\u3067\u306f\u4e2d\u65ad\u3055\u308c\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7d99\u7d9a\u4f8b\u3067\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u3042\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u7d50\u8ad6\u3068\u3057\u3066\u306f\uff0c\u81a0\u82bd\u816b\u306e\u521d\u767a\u4f8b\u3067\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f6\u30b3\u30fc\u30b9\u3067\u6253\u3061\u5207\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3057\u3053\u306e\u4e2d\u3067\uff0cMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308b\u7fa4\u3067\u306f\u3084\u3084\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c\u9577\u3044\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3057\uff0cMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u3042\u308b\u4f8b\u3067\u306f\u73fe\u5b9f\u7684\u306b12\u30b3\u30fc\u30b9\u4ee5\u4e0a\u306e\u6295\u4e0e\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3057\u3087\u3046\u3002<br \/>\nGramatzki D, et al.: Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma. Neurology 2017<br \/>\n\u30c9\u30a4\u30c4\u304b\u3089\u306e\u5831\u544a\u3067\uff0c\u540c\u3058\u547d\u984c\u3092\u8ad6\u3058\u3066\u3044\u307e\u3059\u30027\u30b3\u30fc\u30b9\u4ee5\u4e0a\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u6295\u4e0e\u3067PFS\u3082OS\u3082\u5ef6\u9577\u3067\u304d\u306a\u3044\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>MGMT\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u30fb\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u898b\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u6642<\/h4>\n<ul>\n<li>\u521d\u767a\u81a0\u82bd\u816b\u3067\u306f\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u3063\u3066\u3082\u306a\u304f\u3066\u3082\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f7f\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u9ad8\u9f62\u8005\u306e\u81a0\u82bd\u816b\u3067\u306f\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308b<\/strong><\/span>\u5834\u5408\u306b\u306e\u307f\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>IDH\u91ce\u751f\u578b\u306e\u30b0\u30ec\u30fc\u30c92\u30683\u306e\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u4f75\u7528\u3059\u308b\u6642\u3042\u308b\u3044\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u4f7f\u7528\u3059\u308b\u5834\u5408\u306b\u306f\uff0c\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u3042\u308b\u6642\u306e\u307f\u306b\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<li>EANO\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32017\u5e74\u3067\uff0c\u30a8\u30d3\u30c7\u30f3\u30b9\u30af\u30e9\u30b91\uff0c\u63a8\u5968\u5ea6B\u3067\u3059<\/li>\n<li>\u521d\u767a\u81a0\u82bd\u816b\u3067\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3042\u308c\u3070\uff0c\u518d\u71c3\u6642\u306b\u3082\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<\/ul>\n<h4>\u30b0\u30ec\u30fc\u30c9II \u30b0\u30ea\u30aa\u30fc\u30de\u3067\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u3069\u3061\u3089\u3092\u9078\u629e\u3059\u308b\u304b<\/h4>\n<p>Baumert BG: Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol, 2016<br \/>\n477\u4eba\u306e\u30b0\u30ec\u30fc\u30c9II\u30b0\u30ea\u30aa\u30fc\u30de\u00a0(astrocytoma, oligoastrocytoma, or oligodendroglioma)\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\u3067\u3059\u3002\u6cbb\u7642\u3092\u884c\u3063\u305f\u57fa\u6e96\u306f\u4e88\u5f8c\u304c\u60aa\u305d\u3046\u306b\u601d\u3048\u308b\u4f8b\u3067\uff0c40\u6b73\u4ee5\u4e0a\uff0c\u9032\u884c\u6027\u75c5\u5de3\uff0c\u816b\u760d\u30b5\u30a4\u30ba\u304c5cm\u4ee5\u4e0a\uff0c\u6b63\u4e2d\u3092\u8d85\u3048\u308b\u75c5\u5909\uff0c\u795e\u7d4c\u75c7\u72b6\u304c\u3042\u3063\u305f\u3068\u3044\u3046\u57fa\u6e96\u3067\u3059\u3002\u7121\u4f5c\u70ba\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642 (conformal radiotherapy; up to 50\u00b74 Gy; 28 doses of 1.8 Gy once daily)\u00a0\u3042\u308b\u3044\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u00a0(75 mg\/m2 for 21 days, every 28 days, maximum of 12 cycles)\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<strong><span style=\"color: #000080;\">PFS \u7121\u5897\u60aa\u751f\u5b58\u5272\u5408\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/strong>\u3067\u3057\u305f\u3002\u307e\u305f\uff0c<strong><span style=\"color: #000080;\">\u751f\u5b58\u306e\u8cea\u00a0health-related quality of life (HRQOL)\u306b\u3082\u5dee\u306f\u3042\u308a\u307e\u305b\u3093<\/span><\/strong>\u3067\u3057\u305f\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u5897\u91cf\u3067\u52b9\u679c\u306f\u3042\u304c\u308b\u304b<\/h4>\n<p align=\"left\">Gilbert MR: Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol, 2013<br \/>\nArmstrong TS.: Net clinical benefit analysis of radiation therapy oncology group 0525: a phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma. J Clin Oncol, 2013<br \/>\n<span style=\"color: #ff0000;\"><strong>\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u91cf\u7684\u306b\u591a\u304f\u4f7f\u7528\u3059\u308b\u3053\u3068\u00a0<\/strong><\/span>dose-dense (dose-intensive) temozolomide\u3067\uff0cOS\u3042\u308b\u3044\u306fPFS\u3068\u3044\u3046\u751f\u5b58\u5272\u5408\u304c\u6539\u5584\u3059\u308b\u304b\u3069\u3046\u304b\u3092\uff0c\u81a0\u82bd\u816b\u306e833\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u78ba\u304b\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u7d50\u679c\uff0c<span style=\"color: #ff0000;\"><strong>\u52b9\u679c\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f<\/strong><\/span>\u3002\u307e\u305f\uff0c\u75c7\u72b6\u306e\u6539\u5584\u306a\u3069\u3092\u898b\u305f NCB net clinical benefit\u306f\u4f4e\u4e0b\u3057\u3066\uff0c\u9006\u306b\u75c7\u72b6\uff0c\u5065\u5eb7\u72b6\u614b\uff0c\u65e5\u5e38\u751f\u6d3b\u306e\u8cea\u304c\u4f4e\u4e0b\u3057\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u3002\u30c6\u30e2\u30c0\u30fc\u30eb\u306e\u6295\u4e0e\u91cf\u3092\u5897\u3084\u3057\u3066\u3082\u5229\u76ca\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9 21\u65e5\u9593\u6295\u4e0e\u6cd5\u306e\u8a55\u4fa1<\/h4>\n<p>Brada M, et al.: Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. J Clin Oncol 28: 4601-4608, 2010<br \/>\n\u518d\u767a\u306e\u60aa\u6027\u795e\u7d4c\u81a0\u816b\u306e\u60a3\u8005\u3055\u3093447\u4eba\u306b\u884c\u306a\u308f\u308c\u305f\u5927\u898f\u6a21\u8a66\u9a13\u3067\u3059\u3002PCV (porcarbazine, lomustine, vincristine)\u304c224\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u6295\u4e0e\u3055\u308c\uff0cTMZ (temozolomide) 200 mg\/m2\u3092\uff15\u65e5\u9593\u6295\u4e0e\u304c112\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\uff0c<strong><span style=\"color: #000080;\">TMZ 100 mg\/m2\u3092\u00a021\u65e5\u9593\u9023\u7d9a\u6295\u4e0e\u304c111\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u3044\u305a\u308c\u306e\u7fa4\u3067\u3082\u751f\u5b58\u5272\u5408\u306b\u6709\u610f\u306a\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f<\/span><\/strong>\u3002\u5f93\u6765\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c95\u65e5\u9593\u6295\u4e0e\u3092\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u3067\u751f\u5b58\u671f\u9593\u4e2d\u306eQOL\u304c\u826f\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u5f53\u305f\u308a\u524d\u3067\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c95\u65e5\u9593\u304c\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u304c\u6700\u3082\u8efd\u3044\u3068\u3044\u3046\u3053\u3068\u306f\u5bb9\u6613\u306b\u4e88\u60f3\u304c\u3064\u304f\u3053\u3068\u3067\u3059\u3002<\/p>\n<\/div>\n<h4>\u30c6\u30e2\u30c0\u30fc\u30eb\u3092\u5897\u91cf\u3059\u308b\u8a66\u307f<\/h4>\n<p>Wick W, et al.: New (alternative) temozolomide regimens for the treatment of glioma. Neuro-Oncol 11: 69-78, 2008<\/p>\n<ul>\n<li>5\/28 days regimen : 200mg\/m2\/day, dose intensity\u00a0<span style=\"color: #000080;\"><strong>1,000mg<\/strong><\/span>\/m2\/28 days<\/li>\n<li>28 days\u00a0daily regimen : 75mg\/m2\/day, dose intensity\u00a0<span style=\"color: #000080;\"><strong>1,575mg<\/strong><\/span>\/m2\/28 days<\/li>\n<li>10\/28 days regimen : 150mg\/m2\/day, dose intensity\u00a0<span style=\"color: #000080;\"><strong>1,500mg<\/strong><\/span>\/m2\/28 days<\/li>\n<li>21\/28 days regimen : 75mg\/m2\/day, dose intensity\u00a0<strong>1,875mg<\/strong>\/m2\/28 days<\/li>\n<li>14\/28 days regimen : 150mg\/m2\/day, dose intensity\u00a0<span style=\"color: #000080;\"><strong>2,100mg<\/strong><\/span>\/m2\/28 days<\/li>\n<li>21\/28 days regimen : 100mg\/m2\/day, dose intensity\u00a0<span style=\"color: #000080;\"><strong>2,100mg<\/strong><\/span>\/m2\/28 days<\/li>\n<\/ul>\n<p>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f7f\u7528\u91cf\u3092\u5897\u3084\u3059\u6295\u4e0e\u6cd5\u304c\u8a66\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u5c11\u91cf\u5206\u5272\u6295\u4e0e\u3067\uff0c\u7dcf\u6295\u4e0e\u91cf\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3044\u3046\u65b9\u5411\u3067\u3059\u3002\u3053\u308c\u306f\u816b\u760d\u7d30\u80de\u306e\u4e2d\u306eMGMT\u3068\u3044\u3046\u9175\u7d20\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u7d9a\u3051\u3066\u6295\u4e0e\u3057\u305f\u65b9\u304c\u3044\u3044\u3057\uff0c\u305d\u3046\u3059\u308c\u3070\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6297\u816b\u760d\u52b9\u679c\u304c\u4e0a\u304c\u308b\u3068\u3044\u3046\u63a8\u8ad6\u306b\u57fa\u3065\u3044\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4>\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306e\u9577\u671f\u6210\u7e3e<\/h4>\n<p align=\"left\">Stupp R, et al.: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459-466, 2009<br \/>\n\u5148\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306e\u5927\u898f\u6a21\u7814\u7a76\u306e\u6700\u7d42\u5831\u544a\u3067\u3059\u3002573\u4eba\u306e\u81a0\u82bd\u816b\u306e\u60a3\u8005\u3055\u3093\u304c85\u65bd\u8a2d\u3067\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u5358\u72ec\u6cbb\u7642\u3067\u306f\uff15\u5e74\u5168\u751f\u5b58\u5272\u5408\u306f1.9%\u3067\u3057\u305f\u304c\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3059\u308b\u30689.8% \u3067\u3057\u305f\u3002\u7d71\u8a08\u5b66\u7684\u306b\u5dee\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3067\u81f4\u6b7b\u7684\u809d\u708e\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308b<\/h4>\n<p>Grewal J et al: Fatal reactivation of hepatitis B with temozolomide. N Engl J Med 2007<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u5236\u304c\u3093\u5264\u306a\u306e\u3067\u4f7f\u7528\u3059\u308b\u3068\u3064\u3089\u3044\u3053\u3068\u306b\u306a\u308b\u306e\u304b\uff1f<\/h4>\n<div>\n<p align=\"left\">Taphoorn MJ, et al.: Health-related quality of life in patients with glioblastoma: a randomised controlled trial. Lancet Oncol 6:937-944, 2005<br \/>\n572\u4eba\u306e\u60a3\u8005\u3055\u3093\u306e\u8ffd\u8de1\u8abf\u67fb\u3067\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u98f2\u3093\u3060\u60a3\u8005\u3055\u3093\u3068\uff0c\u98f2\u307e\u306a\u3044\u3067\u653e\u5c04\u7dda\u6cbb\u7642\u3060\u3051\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u306e\u8cea HR-QOL \u304c\uff0c\u9055\u3046\u304b\u3069\u3046\u304b\u306e\u8abf\u67fb\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u7d50\u8ad6\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u526f\u4f5c\u7528\u306e\u305f\u3081\u306bQOL\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u610f\u5473\u3067\u3082\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09\u306e\u8efd\u3044\u5236\u304c\u3093\u5264\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<\/div>\n<div class=\"setumei\"><\/div>\n<p style=\"text-align: left;\">\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e74\u304b\u3089\u306f\uff0c3\u5272\u8ca0\u62c5\u306e\u60a3\u8005\u3055\u3093\u304c300mg\/\u65e5\u306e\u4f7f\u7528\u3067\uff0c\u6708\u306e\u85ac\u5264\u8cbb\u304c7\u4e075,000\u5186\u304b\u30893\u4e071,500\u5186\u307e\u3067\u4e0b\u304c\u308a\u307e\u3057\u305f (^o^)\u30ce \u5546\u54c1\u540d \u30c6\u30e2\u30c0\u30fc\u30eb\u00a0Temodal\uff08\u5148\u767a\uff09\uff0c\u30c6\u30e2\u30be\u30ed\u30df\u30c9 Temozolomi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-156","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=156"}],"version-history":[{"count":66,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/156\/revisions"}],"predecessor-version":[{"id":23160,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/156\/revisions\/23160"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}