{"id":136,"date":"2012-04-17T23:09:06","date_gmt":"2012-04-17T14:09:06","guid":{"rendered":"\/sawamura\/wp\/?p=136"},"modified":"2025-11-18T12:41:00","modified_gmt":"2025-11-18T03:41:00","slug":"olig","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/olig\/","title":{"rendered":"\u4e4f\u7a81\u8d77\u81a0\u816b oligodendroglioma\u3001\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d oligodendroglial tumors"},"content":{"rendered":"<div class=\"setumei\">\n<ul>\n<li><span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u816b\uff08\u307c\u3046\u3068\u3063\u304d\u3053\u3046\u3057\u3085\uff09\u306f\uff0c<a style=\"color: #000080;\" title=\"\u30b0\u30ea\u30aa\u30fc\u30de glioma \u795e\u7d4c\u81a0\u816b\" href=\"\/sawamura\/braintumors\/glioma\/sum\/\">\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b\uff09<\/a><\/strong><\/span>\u3068\u547c\u3070\u308c\u308b\u8133\u816b\u760d\u306e\u4e00\u7a2e\u3067\u3059<\/li>\n<li>\u696d\u754c\u7528\u8a9e\u3067\u307e\u3068\u3081\u3066<strong><span style=\"color: #ff0000;\">\u30aa\u30ea\u30b4<\/span><\/strong>\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>\u30aa\u30ea\u30b4\u306b\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u30b0\u30ec\u30fc\u30c9\uff12<\/strong><span style=\"color: #333333;\">\uff08\u60aa\u6027\u5ea6\u304c\u4f4e\u3044\uff09<\/span><\/span>\u3068<span style=\"color: #ff0000;\"><strong>\u30b0\u30ec\u30fc\u30c9\uff13<\/strong><\/span>\uff08\u60aa\u6027\u5ea6\u304c\u9ad8\u3044\uff09\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u300c\u5b8c\u5168\u306b\u6cbb\u308b\u78ba\u7387\u304c\u9ad8\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u300d<\/span><\/strong>\u3067\u3059\uff0c\u671f\u5f85\u3092\u3082\u3063\u3066\u304d\u3061\u3093\u3068\u3057\u305f\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u3087\u3046<\/li>\n<li>\u8133\u3092\u4f5c\u308b\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u304b\u3089\u767a\u751f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u7570\u8ad6\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u4e3b\u3068\u3057\u3066<span style=\"color: #000080;\"><strong>\u6210\u4eba\u306e\u5927\u8133<\/strong><\/span>\u304b\u3089\u767a\u751f\u3059\u308b\u816b\u760d\u3067\u3059\u304c<span style=\"color: #000080;\"><strong>\u5c0f\u5150\u306b\u3082\u7a00\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li><span style=\"color: #000080;\"><strong>CT\u3067\u77f3\u7070\u5316\uff08\u77f3\u7070\u306e\u56fa\u307e\u308a\u304c\u767d\u304f\u6620\u308b\uff09\u304c\u3042\u308b\u3068\u816b\u760d\u306f\u3086\u3063\u304f\u308a\u5927\u304d\u304f\u306a\u308b<\/strong><\/span>\u3068\u5224\u65ad\u3055\u308c\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c92\u3067\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u3066\u3093\u304b\u3093\u767a\u4f5c\uff08\u3051\u3044\u308c\u3093\uff09\u3067\u767a\u75c7<\/strong><\/span>\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c92\u3067\u306f\uff0c10\u5e74\u4ee5\u4e0a\u304b\u3051\u3066\u3086\u3063\u304f\u308a\u5927\u304d\u304f\u306a\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\uff0c\u816b\u760d\u304c\u898b\u3064\u304b\u3063\u3066\u3082\u614c\u3066\u3066\u958b\u982d\u624b\u8853\u3092\u3057\u306a\u3044<\/li>\n<li><span style=\"color: #000080;\"><strong>\u30b0\u30ec\u30fc\u30c9\uff13\u3060\u3068\uff0c\u6570\u9031\u9593\u306e\u3046\u3061\u306b\u6fc0\u3057\u304f\u5897\u5927\u3059\u308b<\/strong><\/span>\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6d78\u6f64\u6027\u306b\u8133\u306b\u3057\u307f\u8fbc\u3080\u3088\u3046\u306b\u767a\u80b2\u3059\u308b<\/strong><\/span>\u306e\u3067\u5927\u304d\u304f\u306a\u308b\u3068\u6458\u51fa\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u75c5\u7406\u8a3a\u65ad\u304c\u3080\u305a\u304b\u3057<\/strong>\u3044<strong>\u816b\u760d<\/strong><\/span>\u3067\u3059\u304b\u3089\u8133\u816b\u760d\u306b\u8a73\u3057\u3044\u75c5\u7406\u533b\u306e\u5354\u529b\u304c\u5fc5\u8981\u3067\u3059<\/li>\n<li>\u4e00\u822c\u306b\uff0c\u661f\u7d30\u80de \u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u90e8\u5206\u50cf\u304c\u5c11\u306a\u3044\u65b9\u304c\u4e88\u5f8c\u304c\u826f\u3044\u3067\u3059<\/li>\n<li>\u60aa\u6027\u5ea6\u306b\u306f\u3044\u308d\u3044\u308d\u3042\u308a\u307e\u3059\u304c\uff0c\u3069\u306e\u3088\u3046\u306a\u30aa\u30ea\u30b4\u3067\u3082\u5927\u304d\u304f\u306a\u3063\u3066\u8133\u3092\u5e83\u7bc4\u306b\u4fb5\u305b\u3070\u547d\u304c\u5371\u306a\u3044\u75be\u60a3\u306a\u306e\u3067\uff0c\u826f\u6027\u816b\u760d\u3068\u306f\u8003\u3048\u306a\u3044\u65b9\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<li>\u6cbb\u7642\u306f\uff0c<span style=\"color: #000080;\"><strong>\u624b\u8853\u6458\u51fa\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u5316\u5b66\u7642\u6cd5\uff08<a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/temozolo\/\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/a>\uff09\u304c\u6709\u52b9\u3067\u3059\u304b\u3089\u7d44\u307f\u5408\u308f\u305b\u307e\u3059<\/strong><\/span><\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u3067\u3082\uff0c<\/span><strong>\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u306f\u3068\u3066\u3082\u8907\u96d1\u3067\u3059<\/strong><\/span><\/li>\n<li>\u5316\u5b66\u7642\u6cd5\u3060\u3051\u3067\u6cbb\u3059\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3068\u8003\u3048\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<li>\u3064\u3044\u306b2023\u5e74\uff0c\u3044\u307e\u307e\u3067\u6709\u52b9\u306a\u6cbb\u7642\u85ac\u304c\u306a\u304b\u3063\u305f<span style=\"color: #ff0000;\"><strong>\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c9\uff12<\/strong><\/span>\u306b\uff0c<a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliioma-voranigo\/\"><span style=\"color: #ff0000;\"><strong>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u00a0vorasidenib\uff08\u30dc\u30e9\u30cb\u30b4\u3000Voranigo\uff09<\/strong><\/span>\u3068\u3044\u3046\u7d4c\u53e3\u85ac\u304c\u767b\u5834\u3057\u307e\u3057\u305f<\/a>\u3000\u30fe(^\u25bd^)\u30ce<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u65e5\u672c\u3067\u306f\uff0c2024\u5e7412\u6708\u672b\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u627f\u8a8d\u7533\u8acb\u304c\u3055\u308c\u307e\u3057\u305f<\/span><\/strong><\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u306f\uff0c\u7bc4\u56f2\u3092\u7d5e\u3063\u3066\u4f4e\u7dda\u91cf\u306b\u3059\u308b\u3053\u3068\u3092\u3081\u3056\u3057\u307e\u3059<\/li>\n<li>2022\u5e74\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\u30b0\u30ec\u30fc\u30c92\u3067\u3082\u30b0\u30ec\u30fc\u30c93\u3067\u308214\u5e74\u3092\u8d85\u3048\u307e\u3059\u3002<\/li>\n<li><span style=\"color: #000080;\"><strong><span style=\"color: #000080;\"><a style=\"color: #000080;\" title=\"\u661f\u7d30\u80de\u7cfb\u816b\u760d\" href=\"\/sawamura\/braintumors\/glioma\/astrocytictumor\/\">\u661f\u7d30\u80de\u7cfb\u816b\u760d<\/a>\uff08<a style=\"color: #000080;\" title=\"\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\" href=\"\/sawamura\/braintumors\/glioma\/diffuseastrocytoma\/\">\u661f\u7d30\u80de\u816b<\/a>\u3068<a style=\"color: #000080;\" title=\"\u81a0\u82bd\u816b\uff08\u3053\u3046\u304c\u3057\u3085\uff09\" href=\"\/sawamura\/braintumors\/glioma\/glioblastom\/\">\u81a0\u82bd\u816b<\/a>\uff09<\/span>\u3088\u308a\u6cbb\u308b\u671f\u5f85\u306f\u5927\u304d\u3044\u3067\u3059<\/strong><\/span><\/li>\n<\/ul>\n<h5>\u75c7\u72b6<\/h5>\n<ul>\n<li>\u3086\u3063\u304f\u308a\u5897\u6b96\u3059\u308b\u816b\u760d\u3067\uff0c\u6025\u6fc0\u306a\u795e\u7d4c\u75c7\u72b6\u306e\u60aa\u5316\u3092\u898b\u308b\u3053\u3068\u306f\u5c11\u306a\u3044\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u75c7\u5019\u6027\u3066\u3093\u304b\u3093<\/strong><\/span>\uff08\u75c7\u5019\u6027\u5c40\u5728\u95a2\u9023\u3066\u3093\u304b\u3093 SLRE\uff0c\u3051\u3044\u308c\u3093\u767a\u4f5c\uff09<strong><span style=\"color: #000080;\">\u3067\u767a\u75c7\u3059\u308b\u306e\u304c60\u221280%<\/span><\/strong>\u304f\u3089\u3044\u3067\u3059<\/li>\n<li>\u7de9\u5f90\u9032\u884c\u6027\u306e\u8996\u91ce\u969c\u5bb3\uff0c\u534a\u8eab\u306e\u611f\u899a\u969c\u5bb3\u3084\u9ebb\u75fa\uff0c\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3082\u3042\u308a\u307e\u3059<\/li>\n<li>\u982d\u75db\u3084\u5614\u5410\u306a\u3069\u306f\u307e\u308c\u3067\u3059\u304c\uff0c\u307e\u308c\u306b\uff0c<span style=\"color: #000080;\"><strong>\u816b\u760d\u5185\u51fa\u8840<\/strong><strong>\u3092\u751f\u3058\u3066\u6025\u6027\u767a\u75c7<\/strong><\/span>\u3057\u307e\u3059<\/li>\n<li>MRI\u304c\u6c4e\u7528\u3055\u308c\u306a\u304b\u3063\u305f\u6642\u4ee3\u3067\u306f\uff0c\u8a3a\u65ad\u307e\u3067\u306e\u75c7\u72b6\u306e\u7d99\u7d9a\u671f\u9593\u306f\uff0c\u4e2d\u592e\u5024\u30673\u5e74\uff0c\u5e73\u5747\u5024\u30674\u5e74\u3068\u975e\u5e38\u306b\u9577\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3057\u305f<\/li>\n<\/ul>\n<\/div>\n<h5>\u8a3a\u65ad CT<\/h5>\n<ul>\n<li>\u8a3a\u65ad\u306e\u305f\u3081\u306b\u306fCT\u3068MRI\u304c\u5fc5\u9808\u3067\u3059<\/li>\n<li>CT\u3067\u306f\uff0c\u77f3\u7070\u5316\u3084\u306e\u3046\u80de\u3092\u4f34\u3046\u5883\u754c\u4e0d\u9bae\u660e\u306a\u4f4e\u5438\u53ce\u57df\uff08\u9ed2\u3063\u307d\u304f\u898b\u3048\u308b\uff09\u3068\u3057\u3066\u6349\u3048\u3089\u308c\u307e\u3059<\/li>\n<li>\u7279\u306b<strong><span style=\"color: #000080;\">\u77f3\u7070\u5316\u306f\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3068\u306e\u9451\u5225\u8a3a\u65ad\u306b\u975e\u5e38\u306b\u91cd\u8981\u306a<\/span>\u6240\u898b<\/strong>\u3067\u3059<\/li>\n<li>\u8133\u77f3 brain stone\u3068\u3044\u308f\u308c\u308b\u5ca9\u306e\u3088\u3046\u306a\u5927\u304d\u306a\u584a\u306e\u77f3\u7070\u5316\u3082\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10286\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification-550x549.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligocarcification.jpg 709w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\nCT\u3067\u767d\u304f\u898b\u3048\u308b\u306e\u304c\u77f3\u7070\u5316\u3067\u3059\u3002\u5468\u308a\u306e\u5c11\u3057\u9ed2\u3063\u307d\u3044\u3068\u3053\u308d\u306f\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\u3059\u3002CT\u3067\u306f\u816b\u760d\u306e\u5168\u4f53\u50cf\u306f\u898b\u308c\u307e\u305b\u3093\u304b\u3089MRI\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h5>\u8a3a\u65ad\u00a0MRI<\/h5>\n<ul>\n<li>MRI-T1\u5f37\u8abf\u753b\u50cf\u3067\u306f\u4f4e\u4fe1\u53f7\u3068\u306a\u308a\uff0cT2\u5f37\u8abf\u753b\u50cf\u3068\u30d5\u30ec\u30a2\u753b\u50cf\u3067\u306f\u9ad8\u4fe1\u53f7\u57df\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u4e2d\u3067\u306f\uff0cT2\u5f37\u8abf\u753b\u50cf\u3067\u306e\u816b\u760d\u5185\u90e8\u306e\u30b3\u30f3\u30c8\u30e9\u30b9\u30c8\u304c\u5f37\u304f\uff0c\u77f3\u7070\u5316\u306e\u90e8\u5206\u306f\u5f37\u3044\u4f4e\u4fe1\u53f7\u57df\u3068\u3057\u3066\uff0c\u306e\u3046\u80de\u306f\u5747\u4e00\u306a\u5f37\u3044\u9ad8\u4fe1\u53f7\u57df\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u5468\u56f2\u8133\u7d44\u7e54\u6d6e\u816b\u3042\u308b\u3044\u306f\u816b\u760d\u6d78\u6f64\u90e8\u306f\u6de1\u3044\u9ad8\u4fe1\u53f7\u57df\u3068\u3057\u3066\u63cf\u51fa\u3055\u308c\u307e\u3059<\/li>\n<li>\u8133\u6d6e\u816b\u3092\u4f34\u3046\u3082\u306e\u306f\u30b0\u30ec\u30fc\u30c93\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3059<\/li>\n<li>\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u306b\u3088\u308b\u9020\u5f71\u3067\u306f\uff0c\u60aa\u6027\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u306b\u3064\u308c\u3066\u90e8\u5206\u7684\u306a\u5897\u5f37\u50cf\u304c\u5897\u3048\u307e\u3059<\/li>\n<li>\u8133\u8840\u7ba1\u64ae\u5f71 DSA\u306f\u4e0d\u8981\u3067\u3059<\/li>\n<\/ul>\n<h5>MRI\u753b\u50cf\u3067\u306f\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u533a\u5225\u304c\u3064\u304b\u306a\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16450\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2008-2-285x300.jpg\" alt=\"\" width=\"285\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2008-2-285x300.jpg 285w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2008-2.jpg 499w\" sizes=\"auto, (max-width: 285px) 100vw, 285px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2014-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16451\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2014-2-288x300.jpg\" alt=\"\" width=\"288\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2014-2-288x300.jpg 288w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoty2014-2.jpg 513w\" sizes=\"auto, (max-width: 288px) 100vw, 288px\" \/><\/a><\/p>\n<p>\u5de6\u306f\u8133\u30c9\u30c3\u30af\u3067\u767a\u898b\u3055\u308c\u305f\u6642\u306eMRI\u3067\u3059\u3002\u58ee\u5e74\u7537\u6027\u3067\u7121\u75c7\u72b6\u3067\u3057\u305f\u306e\u3067\u7d4c\u904e\u89b3\u5bdf\u3092\u3057\u307e\u3057\u305f\u3002<span style=\"color: #000080;\"><strong>fronto-insulo-temporal glioma<\/strong><\/span>\u3068\u547c\u3070\u308c\u308b\u816b\u760d\u3067\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u533a\u5225\u304c\u3064\u304d\u307e\u305b\u3093\u3002\u53f3\u306f\u7121\u6cbb\u7642\u30676\u5e74\u5f8c\u306e\u753b\u50cf\u3067\u3059\u3002\u3054\u304f\u308f\u305a\u304b\u306b\u5897\u5927\u3057\u3066\u3044\u307e\u3059\u304c\uff0c\u60a3\u8005\u3055\u3093\u306f\u76f8\u5909\u308f\u3089\u305a\u7121\u75c7\u72b6\u3067\u666e\u901a\u306b\u50cd\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u6570\u5e74\u9593\u7d4c\u904e\u3092\u898b\u3066\u3082\u554f\u984c\u306a\u3044\u4f8b\u3082\u3042\u308a\u307e\u3059\u3057\uff0c\u9006\u306b\u6570\u30f6\u6708\u3067\u9855\u8457\u306a\u5897\u5927\u50be\u5411\u3092\u793a\u3059\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u767a\u898b\u3055\u308c\u305f\u3089\u307e\u305a\u306f\uff0cMRI\u3092\uff12\u30f6\u6708\u304f\u3089\u3044\u3067\u7e70\u308a\u8fd4\u3057\u3066\u3069\u306e\u304f\u3089\u3044\u306e\u901f\u3055\u3067\u9032\u884c\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u307f\u308b\u306e\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<hr \/>\n<h3><span style=\"color: #000080;\">2\u3064\u306e\u75c5\u7406\u8a3a\u65ad\u304c\u3042\u3063\u3066\u6cbb\u7642\u6cd5\u304c\u7570\u306a\u308a\u307e\u3059 WHO 2021<\/span><\/h3>\n<h5><strong>1. <span style=\"color: #ff0000;\">\u4e4f\u7a81\u8d77\u81a0\u816b<\/span> <span style=\"color: #ff0000;\">\u30b0\u30ec\u30fc\u30c9 2<\/span>\u00a0<\/strong><\/h5>\n<h5><strong>2. <span style=\"color: #ff0000;\">\u4e4f\u7a81\u8d77\u81a0\u816b<\/span> <span style=\"color: #ff0000;\">\u30b0\u30ec\u30fc\u30c9 3<\/span><\/strong><\/h5>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\u75c5\u7406\u8a3a\u65ad\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>IDH\u907a\u4f1d\u5b50\u5909\u7570\u3068\u7b2c1\u67d3\u8272\u4f53\uff0f\u7b2c19\u67d3\u8272\u4f53\u306e\u6b20\u5931<\/strong><\/span>\u3092\u5fc5\u305a\u8abf\u3079\u307e\u3059<\/li>\n<li>2022\u5e74\u6642\u70b9\u3067\u306f\uff0c<span style=\"color: #000080;\"><strong>FISH<\/strong><\/span>\u3068\u3044\u3046\u8a3a\u65ad\u6cd5\u304c\u6700\u3082\u6c4e\u7528\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>2016\u5e74 WHO\u5206\u985e\u304b\u3089\uff0c<span style=\"color: #ff0000;\"><strong>IDH mutation<\/strong><span style=\"color: #333333;\">\u3068<\/span><strong>1p\/19q codeletion \u304c\u306a\u3044\u3068\u30aa\u30ea\u30b4\u3068\u8a00\u308f\u306a\u3044<\/strong><\/span>\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f<\/li>\n<li>2016\u5e74\u5206\u985e\u3067\u306f\uff0c<strong><span style=\"color: #000080;\">\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u00a0\u30b0\u30ec\u30fc\u30c9 2<\/span>\u00a0<\/strong>OA oligoastrocytoma\u3068<span style=\"color: #000080;\"><strong>\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b \u30b0\u30ec\u30fc\u30c9 3<\/strong><\/span> AOA anaplastic oligoastrocytoma\u304c\u524a\u9664\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u3055\u3089\u306b2021\u5e74\uff0c<span style=\"color: #000080;\"><strong>\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b \u30b0\u30ec\u30fc\u30c9\uff13<\/strong><\/span>\u00a0anaplastic oligodendroglioma \u306e\u75c5\u540d\u304c\u524a\u9664\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u514d\u75ab\u7d44\u7e54\u67d3\u8272\u3067\u660e\u3089\u304b\u306aloss of nuclear ATRX expression\u304c\u3042\u308c\u3070\uff0c\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3067\u3059<\/li>\n<li>\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u30b0\u30ec\u30fc\u30c92\u3068\u30b0\u30ec\u30fc\u30c93\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u50cf\u3067\u6c7a\u5b9a\u3055\u308c\u307e\u3059<\/li>\n<li>\u3053\u306e\u30da\u30fc\u30b8\u3067\u306f\uff0c\u3042\u3048\u3066\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u3084\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u8a18\u8ff0\u3092\u6b8b\u3057\u307e\u3059<\/li>\n<li>\u6d77\u5916\u6587\u732e\u306b\u3082\u65b0\u305f\u306a2021\u5e74WHO\u5206\u985e\u306b\u5373\u3057\u305f\u81e8\u5e8a\u30c7\u30fc\u30bf\u304c\u7121\u3044\u304b\u3089\uff0c\u305d\u306e\u60c5\u5831\u3082\u308f\u304b\u3089\u306a\u3044\u3068\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u306b\u56f0\u308b\u304b\u3089\u3067\u3059<\/li>\n<li>\u3057\u3070\u3089\u304f\u3053\u306e\u6df7\u4e71\u304c\u7d9a\u304d\u307e\u3059<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h4>\u624b\u8853<\/h4>\n<ul>\n<li>\u751f\u6d3b\u306b\u56f0\u308b\u3088\u3046\u306a\u75c7\u72b6\u3092\u51fa\u3059\u5371\u967a\u306e\u3042\u308b\u7121\u7406\u306a\u624b\u8853\u306f\u3057\u307e\u305b\u3093<\/li>\n<li>\u8133\u6df1\u90e8\u306b\u3042\u308b\u304b\u6458\u51fa\u3059\u308b\u3068\u5f8c\u907a\u75c7\u304c\u51fa\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u3082\u306e\u3067\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306e\u305f\u3081\u3060\u3051\u306e\u751f\u691c\u8853\u304c\u9078\u629e\u3055\u308c\u307e\u3059<\/li>\n<li>\u5b8c\u5168\u6458\u51fa\u3059\u308c\u3070\u6cbb\u308b\u306e\u3067\uff0c\u75c7\u72b6\u3092\u51fa\u3055\u306a\u3044\u3067\u5168\u90e8\u53d6\u308c\u308b\u3068\u5224\u65ad\u3059\u308c\u3070\u7a4d\u6975\u7684\u306b\u6458\u51fa\u3057\u307e\u3059<\/li>\n<li>\u816b\u760d\u306e\u304b\u306a\u308a\u306e\u90e8\u5206\u304c\u6458\u51fa\u3067\u304d\u308b\u3068\u5224\u65ad\u3057\u305f\u5834\u5408\u306b\u306f\uff0c\u75c7\u72b6\u3092\u51fa\u3055\u306a\u3044\u7a0b\u5ea6\u306e\u7121\u7406\u306e\u306a\u3044\u958b\u982d\u6458\u51fa\u8853\u3092\u3057\u307e\u3059<\/li>\n<li>\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u306e\u5927\u304d\u306a\u9055\u3044\u306f\uff0c<span style=\"color: #000080;\"><strong>\u9650\u5c40\u6027\u306e\u30aa\u30ea\u30b4\u306f\u624b\u8853\u3067\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308b\u30c1\u30e3\u30f3\u30b9\u304c\u3042\u308a\uff0c\u624b\u8853\u3060\u3051\u3067\u6cbb\u308b\u4f8b\u304c\u3042\u308b<\/strong><\/span><span style=\"color: #333333;\">\u3068\u3044\u3046\u3053\u3068\u3067\u3059<\/span><\/li>\n<li>\u30b0\u30ec\u30fc\u30c93\u3067\u3042\u3063\u3066\u3082\u300c\u5b8c\u5168\u6458\u51fa complete \/ supratotal resection\u300d\u3067\u304d\u308c\u3070\uff0c\u624b\u8853\u3060\u3051\u3067\u6cbb\u7652\u3057\u307e\u3059<\/li>\n<\/ul>\n<h4>\u5316\u5b66\u7642\u6cd5<\/h4>\n<ul>\n<li>\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u6709\u52b9\u3067\u3059<\/li>\n<li>\u85ac\u306f\uff0c<strong><a href=\"\/sawamura\/glioma\/temozolo\/\"><span style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/span><\/a><\/strong>\u304c\u6700\u3082\u6c4e\u7528\u3055\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><span style=\"color: #333333;\">\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u6a19\u6e96\u6cbb\u7642\u3068\u306a\u3063\u3066\u3044\u308b\u00a0<\/span><strong><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/pcvchemotherapy\/\">PCV\u5316\u5b66\u7642\u6cd5<\/a><a style=\"color: #000080;\" href=\"\/sawamura\/glioma\/pcvchemotherapy\/\">\uff08\u30d7\u30ed\u30ab\u30eb\u30d0\u30b8\u30f3\uff0c\u30ed\u30e0\u30b9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff09<\/a><\/strong><span style=\"color: #333333;\">\u306f\uff0c<\/span><\/span>\u65e5\u672c\u3067\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093<\/li>\n<li>\u4e2d\u5fc3\u3068\u306a\u308b\u85ac\u5264\u30ed\u30e0\u30b9\u30c1\u30f3(CCNU)\u304c\u4fdd\u967a\u8a3a\u7642\u8a8d\u53ef\u3055\u308c\u3066\u3044\u306a\u3044\u304b\u3089\u3067\u3059<\/li>\n<li>\u9ad8\u4fa1\u306a\u85ac\u3068\u306a\u308a\uff0c\u7c73\u56fd\u3067\u30822021\u5e74\u306b\u4fdd\u967a\u8a3a\u7642\u3067\u306e\u8a8d\u53ef\u304c\u53d6\u308a\u6d88\u3055\u308c\u307e\u3057\u305f<\/li>\n<li><span style=\"color: #000080;\"><strong>2023\u5e74\u306b\uff0c<span style=\"color: #ff0000;\"><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliioma-voranigo\/\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib<\/a><span style=\"color: #000080;\">\uff08\u98f2\u307f\u85ac\uff09<\/span><\/span>\u306e\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\uff0c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577<\/strong><\/span>\u304c\u8a3c\u660e\u3055\u308c\u307e\u3057\u305f\uff0c\u7c73\u56fd\u3067\u8a8d\u53ef\u3055\u308c\u3002\u3082\u3046\u3059\u3050\u65e5\u672c\u3067\u3082\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u306e\u3067\u3057\u3087\u3046<\/li>\n<li><span style=\"color: #000080;\"><strong>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u767b\u5834\u3067\uff0c\u304a\u305d\u3089\u304f\u5316\u5b66\u7642\u6cd5\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u5909\u308f\u308a\u307e\u3059<\/strong><\/span><\/li>\n<li>\u30cb\u30c9\u30e9\u30f3\u3092\u30ed\u30e0\u30b9\u30c1\u30f3\u306e\u4ee3\u308f\u308a\u306b\u4f7f\u3046PAV\u5316\u5b66\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306f\u5168\u304f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<\/ul>\n<h5><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/gliioma-voranigo\/\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u4f7f\u3044\u65b9<\/a><\/h5>\n<p>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u3092\u6295\u4e0e\u3059\u308b\u3068\u5909\u7570\u578b\u306eIDH1\/2\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u3092\u6291\u3048\u3066\uff0c\u816b\u760d\u7d30\u80de\u5185\u306e2-HG\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002\u305d\u3046\u3059\u308b\u3068\u816b\u760d\u7d30\u80de\u304a\u5897\u6b96\u80fd\u304c\u4f4e\u304f\u306a\u3063\u3066\u816b\u760d\u5897\u5927\u3092\u6291\u5236\u3057\u307e\u3059\u3002<br \/>\n\u81e8\u5e8a\u306e\u5834\u3067\u306f\uff0c\u7d4c\u53e3\u6295\u4e0e\u3067\u30dc\u30e9\u30b7\u30c7\u30cb\u30d640mg\u3092\u6bce\u65e5\u4e00\u56de\uff0c\u6c7a\u307e\u3063\u305f\u540c\u3058\u6642\u9593\u306b\u670d\u7528\u3057\u307e\u3059\u3002\u6bce\u671d\u306e\u671d\u98df\u5f8c\u3068\u304b\uff0c\u5915\u98df\u5f8c\u3068\u304b\u3067\u3059\u3002\u565b\u307e\u305a\u306b\u98f2\u307f\u8fbc\u307f\u307e\u3059\u3002<br \/>\n\u5bfe\u8c61\u306f\uff0c12\u6b73\u4ee5\u4e0a\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u304b\u4e4f\u7a81\u8d77\u81a0\u816b\uff0cIDH1\/2\u5909\u7570\u304c\u3042\u308b\u3053\u3068\uff0c\u624b\u8853\u5f8c\u3067\u751f\u691c\u8853\u3067\u3082\u90e8\u5206\u6458\u51fa\u3067\u3082\u5168\u6458\u51fa\u3067\u3082\u6295\u4e0e\u3067\u304d\u307e\u3059\u3002\u65e5\u672c\u3067\u306f\uff0c\u65e5\u672c\u30bb\u30eb\u30f4\u30a3\u30a8\u304c2024\u5e7412\u670824\u65e5\u3001\u6297\u304c\u3093\u5264\u30fb\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u30af\u30a8\u30f3\u9178\u6c34\u548c\u7269\u306b\u3064\u3044\u3066\u3001IDH1\u53c8\u306fIDH2\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u306e\u795e\u7d4c\u81a0\u816b\u3092\u5bfe\u8c61\u75be\u60a3\u306b\u627f\u8a8d\u7533\u8acb\u3057\u307e\u3057\u305f\u3002<\/p>\n<h5>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306e\u526f\u4f5c\u7528\uff08\u6709\u5bb3\u4e8b\u8c61\uff09<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-23079\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib-235x300.png\" alt=\"\" width=\"235\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib-235x300.png 235w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/vorasidenib.png 434w\" sizes=\"auto, (max-width: 235px) 100vw, 235px\" \/><br \/>\n<span style=\"color: #000080;\"><strong>\u5026\u6020\u611f\uff0c\u75b2\u52b4\u611f\uff0c<\/strong><strong>\u982d\u75db\uff0c\u5614\u6c17\uff0c\u4e0b\u75e2<\/strong><\/span>\uff0c\u7b4b\u8089\u75db\uff08\u9aa8\u683c\u7b4b\u75db\uff09\uff0c\u95a2\u7bc0\u75db\uff0c\u4fbf\u79d8\uff0c\u98a8\u90aa\u306a\u3069\u306e\u611f\u67d3\u75c7\uff0c\u7a00\u306b\u3066\u3093\u304b\u3093\u767a\u4f5c<br \/>\n\u8840\u6db2\u691c\u67fb\u3067\u306f\uff0cALT, AST, \u03b3-GTP, ALP, \u30d3\u30ea\u30eb\u30d3\u30f3\u4e0a\u6607\uff0c\u597d\u4e2d\u7403\u6e1b\u5c11\u3067\u3059\u3002\u81d3\u5668\u969c\u5bb3\u3067\u306f\u809d\u969c\u5bb3\u304c\u3082\u3063\u3068\u3082\u983b\u5ea6\u304c\u9ad8\u3044\u3067\u3059\u3002<br \/>\n\u3072\u3069\u3044<span style=\"color: #000080;\"><strong>\u5026\u6020\u611f\u304c\u65e5\u5e38\u751f\u6d3b\u306e\u969c\u5bb3<\/strong><\/span>\u3068\u306a\u308a\u307e\u3059\u304c\uff0c\u4f53\u529b\u3092\u306a\u304f\u3055\u306a\u3044\u7a0b\u5ea6\u306b\u904b\u52d5\u3057\u3066\uff0c\u307e\u305f\u5927\u4e8b\u306a\u4ed5\u4e8b\u306e\u305f\u3081\u306b\u4f11\u61a9\u3092\u3068\u3063\u3066\u3068\u3044\u3046\u30d0\u30e9\u30f3\u30b9\u304c\u5927\u5207\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h5>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u5316\u5b66\u7642\u6cd5\u306e\u4f8b<\/h5>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15002\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15003\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15004\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera10-3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<\/div>\n<p>2010\u5e74\u7121\u75c7\u72b6\u306e\u6642\u306e\u753b\u50cf\u3067\u3059\u3002\u3053\u3093\u306a\u306e\u3092\u624b\u8853\u3067\u6458\u51fa\u3057\u305f\u3089\u8a8d\u77e5\u6a5f\u80fd\u304c\u843d\u3061\u3066\u4eba\u683c\u304c\u5909\u308f\u308a\u307e\u3059\u3002\u3060\u304b\u3089\u7d4c\u904e\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15005\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15006\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15007\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera15-3-298x300.jpg 298w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p>2015\u5e74\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u958b\u59cb\u3059\u308b\u524d\u306e\u753b\u50cf\u3067\u3059\u30022014\u5e74\u306b\u3061\u3087\u3073\u3063\u3068\u751f\u691c\u8853\u3092\u3057\u30661p\/19q\u6b20\u5931\uff0cIDH\u5909\u7570\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u30022015\u5e74\u306b\u5168\u822c\u767a\u4f5c\u3092\u8d77\u3053\u3057\u305f\u306e\u3067\u6cbb\u7642\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092 2\u5e74 24\u30b3\u30fc\u30b9\u7d9a\u3051\u307e\u3057\u305f\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u306f\u5927\u304d\u304f\u306a\u308b\u6642\uff0c\u3066\u3093\u304b\u3093\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15008\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1-298x300.jpg 298w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1-550x554.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1-768x773.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-1.jpg 850w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15009\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-15010\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotera20-3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/><\/a><\/p>\n<p>2020\u5e74\u306e\u753b\u50cf\u3067\u3059\u3002\u816b\u760d\u306f\u304b\u306a\u308a\u5c0f\u3055\u304f\u306a\u3063\u3066\u518d\u71c3\uff08\u518d\u767a\uff09\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u3066\u3093\u304b\u3093\u3082\u6291\u5236\u3055\u308c\u3066\u767a\u4f5c\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7121\u75c7\u72b6\u3067\u3059\u3002<\/p>\n<h5>\u3053\u306e\u4f8b\u306f\uff0c\u624b\u8853\u3082\u653e\u5c04\u7dda\u6cbb\u7642\u3082\u3057\u306a\u3044\u3067\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u304c10\u5e74\u4ee5\u4e0a\uff0c\u5236\u5fa1\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u6cbb\u7642\u3067\u3066\u3093\u304b\u3093\u767a\u4f5c\u304c\u5c11\u306a\u304f\u306a\u308b\u3053\u3068\u3082\u6709\u540d\u306a\u4e8b\u5b9f\u3067\u3059\u3002<\/h5>\n<h5>\u3067\u3082\uff0c\u73fe\u5b9f\u306f\u3053\u3093\u306a\u306b\u7518\u304f\u306a\u3044? \u00a02025\u5e74\u6642\u70b9\u3067\uff0c\u6cbb\u7652\u3092\u76ee\u6307\u3059\u306a\u3089\u4f4e\u7dda\u91cf\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u52a0\u3048\u308b\u3079\u304d\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/h5>\n<h4>\u653e\u5c04\u7dda\u6cbb\u7642<\/h4>\n<p>\u30b0\u30ec\u30fc\u30c9\uff12\u3068\uff13\u3067\u306f\u5927\u304d\u306a\u9055\u3044\u304c\u3042\u308b\u306e\u3067\uff0c\u4e0b\u306e\u65b9\u3092\u8aad\u3093\u3067\u304f\u3060\u3055\u3044<\/p>\n<h4><a href=\"\/sawamura\/braintumors\/epilepsy\/\">\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u6cbb\u7642\u306f\u5225\u30da\u30fc\u30b8\u306b\u3042\u308b\u306e\u3067\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af<\/a><\/h4>\n<p>\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c9\uff12\u3067\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\uff0c\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\u767a\u4f5c\u304c\u8efd\u6e1b\u3059\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u624b\u8853\u3067\u3082\u653e\u5c04\u7dda\u6cbb\u7642\u3067\u3082\u5316\u5b66\u7642\u6cd5\u3067\u3082\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u6709\u52b9\u306a\u6cbb\u7642\u304c\u306a\u3055\u308c\u308c\u3070\uff0c\u3066\u3093\u304b\u3093\u767a\u4f5c\u306f\u6d88\u5931\u3059\u308b\u304b\u6291\u5236\u3055\u308c\u307e\u3059\u3002\u9006\u306b\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u518d\u767a\uff0f\u518d\u71c3\u3059\u308b\u6642\u306b\u306f\uff0c\u3066\u3093\u304b\u3093\u767a\u4f5c\u304c\u751f\u3058\u307e\u3059\u3002<\/p>\n<h4>\u4e88\u5f8c<\/h4>\n<ul>\n<li>\u904e\u53bb\u306e\u8a66\u9a13\u306b\u3088\u308c\u30701p\/19q\u6b20\u5931\u304c\u3042\u308b\u3082\u306e\u3067\uff0c<\/li>\n<li><span style=\"color: #000080;\"><strong>\u30b0\u30ec\u30fc\u30c92\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c14\u5e74\u4ee5\u4e0a<\/strong><\/span>\u3068\u3055\u308c\u307e\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u30b0\u30ec\u30fc\u30c93\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c14\u5e74\u4ee5\u4e0a<\/span><\/strong>\u3068\u3055\u308c\u307e\u3059<\/li>\n<li>\u307e\u308c\u3067\u3059\u304c\uff0chomozygous deletion of <span style=\"color: #000080;\"><strong><i>CDKN2A<\/i><\/strong><\/span> at 9p21\u306e\u3042\u308b\u3082\u306e\u306e\u4e88\u5f8c\u306f\u4e0d\u826f\u3067\u3059<\/li>\n<\/ul>\n<div class=\"setumei\">\n<hr \/>\n<h3><span style=\"color: #000080;\">\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u30aa\u30ea\u30b4 \u4e4f\u7a81\u8d77\u81a0\u816b<\/span><\/h3>\n<\/div>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-10864\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi3-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi3-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi34.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-10865 size-thumbnail\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi34-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi34-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi34-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\n\u5e73\u5747\u7684\u306a\u5897\u5927\u901f\u5ea6\u3092\u793a\u3057\u305f\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c9\uff12\u3067\u3059\u3002\u5de6\u304c\u7121\u75c7\u72b6\u3067\u767a\u898b\u3055\u308c\u305f\u6642\uff0c\u53f3\u304c3\u5e74\u5f8c\u3067\uff0c\u3054\u304f\u308f\u305a\u304b\u306b\u5897\u5927\u3057\u3066\u3044\u307e\u3059\u3002\u958b\u982d\u624b\u8853\u3067\u6458\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-10860 size-thumbnail\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi2-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi2-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-10861 size-thumbnail\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1-298x300.jpg 298w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1-550x554.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1-144x144.jpg 144w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligohi1.jpg 945w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/a><br \/>\nHE\u67d3\u8272\u3067\u306f\u7d30\u80de\u6838\u306e\u5468\u308a\u304c\u629c\u3051\u308b\u3088\u3046\u306a\u5178\u578b\u7684\u306ahalo\uff08\u5de6\u5074\u306e\u5199\u771f\uff09\u304c\u3042\u308a\u307e\u3059\u30021p\/19q\u6b20\u5931\u304c\u3042\u308a\uff0cMIB\u67d3\u8272\u7387\uff08\u53f3\u5074\uff09\u306f4%\u3067\u3057\u305f\u3002<\/p>\n<hr \/>\n<ul>\n<li><span style=\"color: #000000;\"><strong><span style=\"color: #ff0000;\">\u6570\u5e74\u5358\u4f4d\u3067\u3086\u3063\u304f\u308a\u5927\u304d\u304f\u306a\u308b<\/span><\/strong>\u3082\u306e\u304c\u591a\u3044\u3067\u3059<\/span><\/li>\n<li><span style=\"color: #000000;\">\u5206\u5316\u5ea6\u306e\u9ad8\u3044\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u30aa\u30ea\u30b4\u306f20-30\u5e74\u3082\u304b\u304b\u3063\u3066\u3086\u3063\u304f\u308a\u5927\u304d\u304f\u306a\u3063\u3066\u75c7\u72b6\u3092\u51fa\u3059\u3082\u306e\u3082\u3042\u308a\u307e\u3059<\/span><\/li>\n<li>\u306a\u304b\u306b\u306f\uff0c20\u5e74\u89b3\u5bdf\u3057\u3066\u3082\u307b\u3068\u3093\u3069\u5897\u5927\u3057\u306a\u3044\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff0c\u30b0\u30ec\u30fc\u30c9\uff11\u3068\u8a00\u3063\u3066\u3082\u3088\u3044\u3088\u3046\u306a\u30aa\u30ea\u30b4\u3067\u3059<\/li>\n<li>\u5341\u5e74\u4ee5\u4e0a\u306b\u304a\u3088\u3076\u300c\u3066\u3093\u304b\u3093\u300d\u3092\u6709\u3059\u308b\u9ad8\u9f62\u8005\u3067\uff0c\u77f3\u7070\u5316\u3092\u4f34\u3046\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u7591\u308f\u308c\u305f\u3089\uff0c\u6297\u3051\u3044\u308c\u3093\u5264\u306e\u6295\u4e0e\u306e\u307f\u3067\u7d4c\u904e\u3092\u307f\u3066\u3082\u3088\u3044\u3067\u3059<\/li>\n<li>\u305f\u3060\u3057\uff0c\u30b0\u30ec\u30fc\u30c9\uff12\u3068\u8003\u3048\u3089\u308c\u308b\uff0c\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3044\uff0c\u5468\u56f2\u306e\u8133\u3092\u5727\u8feb\u3057\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u6761\u4ef6\u4e0b\u3067\u3059<\/li>\n<li>\u3086\u3063\u304f\u308a\u3068\u306f\u3044\u3048\uff0c\u5927\u304d\u304f\u306a\u3063\u3066\u304f\u308b\u816b\u760d\u306a\u306e\u3067\uff0c\u82e5\u3044\u4eba\u3067\u306f\u7a4d\u6975\u7684\u306b\u6cbb\u7642\u3092\u8003\u3048\u307e\u3059<\/li>\n<li>\u6cbb\u7642\u306f\u624b\u8853\u3067\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\u6cbb\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u300c\u304b\u306a\u308a\u78ba\u5b9f\u306b\u300d\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3084\u5316\u5b66\u7642\u6cd5\u3092\u3057\u306a\u3044\u3067\u7d4c\u904e\u89b3\u5bdf<\/strong><\/span>\u3057\u307e\u3059<\/li>\n<li>\u3057\u304b\u3057\uff0c\u6b8b\u5ff5\u306a\u304c\u3089\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308b\u983b\u5ea6\u306f\u9ad8\u304f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u30b0\u30ec\u30fc\u30c92\u306f\u4e88\u5f8c\u304c\u826f\u3044\u306e\u3067\u75c7\u72b6\u3092\u60aa\u5316\u3055\u305b\u3066\u307e\u3067\u306f\u7121\u7406\u306b\u6458\u51fa\u3057\u307e\u305b\u3093<\/li>\n<li>40\u6b73\u4ee5\u4e0b\u306e\u60a3\u8005\u3055\u3093\u3067\uff0c\u3066\u3093\u304b\u3093\u767a\u4f5c\u3057\u304b\u75c7\u72b6\u304c\u306a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u624b\u8853\u5f8c\u306b\u5c11\u3057\u816b\u760d\u304c\u6b8b\u3063\u3066\u3082\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3057\u306a\u3044\u3067\u307e\u305a\u7d4c\u904e\u3092\u898b\u308b\u3068\u3044\u3046\u610f\u898b\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3067\u3082\u6b8b\u5ff5\u306a\u304c\u3089\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3067\u6b8b\u3063\u305f\u816b\u760d\u306f\u5897\u5927\u3057\u3066\u5e83\u304c\u3063\u3066\u3044\u304d\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u306f<span style=\"color: #333399;\"><a style=\"color: #333399;\" href=\"\/sawamura\/glioma\/pcvchemotherapy\/\">PCV\u5316\u5b66\u7642\u6cd5<\/a><\/span>\u304c\u7b2c\u4e00\u9078\u629e<\/strong><\/span>\u3067\u3059\u304c\uff0c\u65e5\u672c\u3067\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093<\/li>\n<li>\u624b\u8853\u5f8c\u306b\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3067\u6570\u5e74\u4ee5\u4e0a\u816b\u760d\u5236\u5fa1\u304c\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f<\/li>\n<li>\u3067\u3082\u3053\u308c\u306f\u3042\u308b\u7a0b\u5ea6\uff0c\u816b\u760d\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3068\u3044\u3046\u52b9\u679c\u306e\u8a55\u4fa1\u306b\u304a\u3044\u3066\u3067\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u52a0\u3048\u306a\u3044\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u306f\uff0c\u816b\u760d\u3092\u6cbb\u3059\u529b\u306f\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u3067\u3059\u3068\uff0c\u6cbb\u7642\u5f8c\u6570\u5e74\u306e\u9577\u671f\u3092\u898b\u308c\u3070\u518d\u71c3\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304b\u3089\u3067\u3059<\/li>\n<li>\u3067\u3082\u82e5\u3044\u60a3\u8005\u3055\u3093\u3067\uff0c\u300c\u6cbb\u7652 true cure\u300d\u3092\u76ee\u6307\u3059\u306e\u3067\u3042\u308c\u3070\uff0c<strong><span style=\"color: #000080;\">\u624b\u8853\u5f8c\u306b\u6b8b\u3063\u305f\u816b\u760d\u306b\u306f50 (45-54) \u30b0\u30ec\u30a4\u7a0b\u5ea6\u306e\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30c0\u30fc\u30eb\u5316\u5b66\u7642\u6cd5<\/span><\/strong>\u3092\u3057\u307e\u3059<\/li>\n<li>2024\u5e74\uff0c\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c\u3067\uff0c\u521d\u671f\u6cbb\u7642\u3067\u653e\u5c04\u7dda\u6cbb\u764250.4Gy18\u5206\u5272\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u52a0\u3048\u305f\u65b9\u304c10\u5e74\u751f\u5b58\u5272\u5408\u304c40\uff05\u304b\u308970\uff05\u307e\u3067\u4e0a\u6607\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6700\u9069\u6295\u4e0e\u671f\u9593\u306b\u95a2\u3057\u3066\u3082\u306f\u3063\u304d\u308a\u3057\u305f\u30c7\u30fc\u30bf\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n<li><a title=\"\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff0c\u30c6\u30e2\u30c0\u30fc\u30eb\uff09temozolomide\" href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/temozolo\/\"><span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/strong><\/span><\/a>\u306f\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u306a\u306e\u3067\u767a\u764c\u6027\u3092\u6709\u3057\u3066\u3044\u307e\u3059\uff0c\u9577\u671f\u6295\u4e0e\u3059\u308b\u3068\u767d\u8840\u75c5\u306a\u3069\u3092\u751f\u3058\u308b\u3053\u3068\u3082\u3042\u308b\u5316\u5b66\u7642\u6cd5\u5264\u3067\u3059<\/li>\n<li>\u9577\u671f\u751f\u5b58\u3084\u6cbb\u7652\u3068\u3044\u3046\u3053\u3068\u3092\u76ee\u6307\u3059\u5834\u5408\u306b\u306f\uff0c\u4f4e\u7dda\u91cf\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u307b\u3046\u304c\u826f\u3044\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u6cbb\u308b\u671f\u5f85\u304c\u3082\u3066\u308b\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u3067\u3059<\/li>\n<\/ul>\n<h4>\u624b\u8853\u3067\u304d\u306a\u3044\u5927\u304d\u306a\u30b0\u30ec\u30fc\u30c93\u3067\u3082\u6cbb\u308b\u671f\u5f85\u304c\u3042\u308b<br \/>\n\u899a\u9192\u4e0b\u624b\u8853\u306a\u3069\u306e\u7a4d\u6975\u7684\u306a\u624b\u8853\u3092\u3057\u3066\u306f\u3044\u3051\u306a\u3044<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16458\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3-550x550.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3-768x768.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott3.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16459\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2-550x550.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2-768x768.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott2.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotthe.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16462\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotthe-300x300.jpg\" alt=\"oligotthe\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotthe-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotthe-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligotthe.jpg 475w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n\u82e5\u3044\u5973\u6027\u306e\u5de6\u524d\u982d\u8449\u304b\u3089\u5cf6\u56de\uff0c\u5074\u982d\u8449\u3092\u4fb5\u3059\u816b\u760d\u3067\uff0c\u3066\u3093\u304b\u3093\u767a\u4f5c\u3067\u767a\u75c7\u3057\uff0c\u958b\u982d\u751f\u691c biopsy \u3057\u307e\u3057\u305f\u3002<br \/>\n\u4e00\u90e8\u3067\uff0c\u7d30\u80de\u5bc6\u5ea6\u304c\u9ad8\u304f\uff0c\u6838\u306e\u816b\u5927\u3068\u30af\u30ed\u30de\u30c1\u30f3\u306e\u5897\u91cf\uff0c\u6838\u9593\u8ddd\u96e2\u306e\u77ed\u7e2e\u304c\u3042\u308a\uff0c\u6838\u5206\u88c2\u50cf\u304c\u8a8d\u3081\u3089\u308c\uff0cMIB-1\u67d3\u8272\u7387\u304c10%\u3067\u3059\u3002\u7d44\u7e54\u5b66\u7684\u306b\u306f\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c93\u3068\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nIDH\u5909\u7570\u3042\u308a\uff0c1P\/19q\u6b20\u5931\u3042\u308a\uff0cATRX\u5909\u7570\u306a\u3057\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16460\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4-550x550.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4-768x768.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott4.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u30b0\u30ea\u30aa\u30fc\u30de\u306a\u306e\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u9ad8\u7dda\u91cf\u9818\u57df\u306f\u3042\u307e\u308a\u5e83\u304f\u3068\u308a\u307e\u305b\u3093\u3002<br \/>\nIMRT Simultaneous Integrated Boost (SIB)\u3067\uff0cFLAIR\u9ad8\u4fe1\u53f7\u306e\u9818\u57df\u306b54\u30b0\u30ec\u30a427\u5206\u5272\uff0c\u5468\u56f2\u4eee\u5b9a\u6d78\u6f64\u9818\u57df generous local area\u306b46\u30b0\u30ec\u30a4\u3092\u7167\u5c04\u3057\u307e\u3057\u305f\u3002<br \/>\n\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c975mg\/m2\u3092\u4f75\u7528\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u5de6\u306e\u753b\u50cf\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u76f4\u5f8c\u306eMRI\u3067\u3059\u304c\uff0c\u3059\u3067\u306b\u816b\u760d\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-16461\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6-550x550.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6-768x768.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligott6.jpg 886w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u7dad\u6301\u7642\u6cd5\u306f\uff0c24\u30b3\u30fc\u30b9 \uff12\u5e74\u9593\u884c\u3044\uff0c\u305d\u308c\u4ee5\u964d\u306f\u7121\u6cbb\u7642\u3068\u3057\u307e\u3057\u305f\u3002<br \/>\n\u7167\u5c04\u5f8c7\u5e74\u306e\u753b\u50cf\u3067\u3059\u3002\u816b\u760d\u306f\u7e2e\u5c0f\u3057\u305f\u307e\u307e\uff0c\u60a3\u8005\u3055\u3093\u306f\u7121\u75c7\u72b6\u3067\u7d4c\u904e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><span style=\"color: #000080;\">\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4 \u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b<\/span><\/h3>\n<div>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">\u60aa\u6027\u5ea6\u306e\u3084\u3084\u9ad8\u3044\u3082\u306e<\/span><\/strong>\u3067\u3059<\/li>\n<li><span style=\"color: #333333;\">2015\u5e74\u307e\u3067\u306f\uff0c<\/span><strong><span style=\"color: #000080;\">\u7b2c1\u67d3\u8272\u4f53\u3068\u7b2c19\u67d3\u8272\u4f53\u306e\u6b20\u5931<\/span><\/strong>( 1p\/19q codeletion) \u304c\u5927\u90e8\u5206\u306e\u816b\u760d\u7d30\u80de\u306b\u8a8d\u3081\u3089\u308c\u308b\u5834\u5408\u306b\u306f\uff0c\u751f\u5b58\u671f\u9593\u306f\u5927\u5e45\u306b\u5ef6\u3073\u308b\u3068\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>2016\u5e74\u306bWHO\u7d44\u7e54\u8a3a\u65ad\u304c\u5909\u308f\u3063\u305f\u306e\u306720\u5e74\u5358\u4f4d\u306e\u9577\u671f\u4e88\u5f8c\u306f\u4e16\u754c\u306e\u8ab0\u306b\u3082\u308f\u304b\u3089\u306a\u304f\u306a\u308a\u307e\u3057\u305f<\/li>\n<li>\u30b0\u30ec\u30fc\u30c9\uff13\u306e<span style=\"color: #000080;\"><strong>\uff15\u5e74\u751f\u5b58\u5272\u5408\u306f75\uff05<\/strong><\/span>\u304f\u3089\u3044\u3067\u3059<\/li>\n<\/ul>\n<\/div>\n<ul>\n<li>\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4\u5168\u4f53\u306e<span style=\"color: #000080;\"><strong>\u5e73\u5747\u4f59\u547d\u306f10\u5e74\u4ee5\u4e0a\u3067\u3057\u3087\u3046<\/strong><\/span><\/li>\n<li>\u6cbb\u3063\u3066\u3057\u307e\u3063\u306630\u5e74\u751f\u5b58\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3082\u3044\u307e\u3059<\/li>\n<li>\uff11\u30f6\u6708\u304f\u3089\u3044\u3067\u3073\u3063\u304f\u308a\u3059\u308b\u304f\u3089\u3044\u5e83\u304c\u3063\u3066\u3057\u307e\u3046\u3082\u306e\u3082\u3042\u308a\u3001<span style=\"color: #000080;\"><strong>\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c9\uff13\u3068\u3044\u3063\u3066\u3082\u5343\u5dee\u4e07\u5225<\/strong><\/span>\u3067\u3059\u304b\u3089\uff0c\u6cbb\u7642\u9078\u629e\u306e\u5224\u65ad\u306f\u6025\u3044\u3067\u304f\u3060\u3055\u3044<\/li>\n<li><span style=\"color: #000080;\"><strong>\u624b\u8853\u3067\u3067\u304d\u308b\u3060\u3051\u591a\u304f\u53d6\u3063\u305f\u65b9\u304c\u6cbb\u308b\u78ba\u7387\u304c\u5897\u3057\u307e\u3059\u304c\uff0c\u7121\u7406\u306f\u3057\u306a\u3044<\/strong><\/span><\/li>\n<li>40\u6b73\u4ee5\u4e0b\u306e\u82e5\u3044\u60a3\u8005\u3055\u3093\u3067\uff0c\u624b\u8853\u3067\u300c<strong><span style=\"color: #ff0000;\">\u3082\u3057<\/span><\/strong>\u78ba\u5b9f\u306b\u300d\u5b8c\u5168\u6458\u51fa\u3067\u304d\u308c\u3070\uff0c\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u3057\u306a\u3044\u3067\u7d4c\u904e\u89b3\u5bdf\u3082\u3067\u304d\u307e\u3059<\/li>\n<li>\u3057\u304b\u3057\uff0c\u907a\u4f1d\u5b50\u691c\u67fb\u3067<span style=\"color: #000080;\"><strong>homozygous <i>CDKN2A\/B\u00a0<\/i>deletion\u304c\u3042\u308b\u3082\u306e\u306f\u7d4c\u904e\u89b3\u5bdf\u3067\u304d\u305a\uff0c\u3059\u3050\u306b60\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u307e\u3059<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\">\u8853\u5f8c\u306b\u306f<\/span><span style=\"color: #ff0000;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5<\/strong><\/span>\u3092\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #333333;\">\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4\u306b\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306b\uff0c<a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/pcvchemotherapy\/\"><span style=\"color: #000080;\"><strong>PCV\u5316\u5b66\u7642\u6cd5<\/strong><\/span><\/a>\uff08\u30d7\u30ed\u30ab\u30eb\u30d0\u30b8\u30f3\u3001\u30ed\u30e0\u30b9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff09\u3092\u52a0\u3048\u308b\u3068\u751f\u5b58\u671f\u9593\u304c\u5ef6\u9577\u3067\u304d\u307e\u3059<\/span><\/li>\n<li>1p\/19q\u6b20\u5931\u304c\u3042\u308aPCV\u5316\u5b66\u7642\u6cd5\u3092\u7528\u3044\u308b\u3068\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f14\u5e74\u3092\u8d8a\u3048\u308b\u3068\u3055\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #333333;\"><span style=\"color: #000080;\"><strong>\u65e5\u672c\u3067\u306f\u30ed\u30e0\u30b9\u30c1\u30f3 CCNU \u304c\u4f7f\u3048\u306a\u3044<\/strong><\/span>\u306e\u3067\u30cb\u30c9\u30e9\u30f3 ACNU \u3092\u66ff\u308f\u308a\u306b\u4f7f\u7528<\/span>\uff08PAV\u7642\u6cd5\uff09\u3057\u307e\u3059\u304c\u3001\u79d1\u5b66\u7684\u306b\u6709\u52b9\u6027\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\uff0c\u4f7f\u7528\u3059\u308b\u6839\u62e0\u304c\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u30ed\u30e0\u30b9\u30c1\u30f3\u306f\u500b\u4eba\u8f38\u5165\u3067\u5165\u624b\u3067\u304d\u307e\u3059\u304c\u9ad8\u4fa1\u3067\u624b\u304c\u51fa\u307e\u305b\u3093<\/li>\n<li>2021\u5e74\u73fe\u5728\uff0cPCV\u7642\u6cd5\u3088\u308a\u3082\uff0c<span style=\"color: #000080;\"><strong><span style=\"color: #ff0000;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9<\/span><\/strong><span style=\"color: #000000;\">\u3092\u4f7f\u7528\u3059\u308b\u50be\u5411\u304c\u4e16\u754c\u7684\u306b\u4e00\u822c\u7684\u3067\u3059<\/span><\/span><\/li>\n<li>PCV\u3088\u308a\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u65b9\u304c\u526f\u4f5c\u7528\u304c\u5c11\u306a\u304f\u3066\u4f7f\u3044\u3084\u3059\u3044\u306e\u304c\u4e00\u756a\u5927\u304d\u306a\u73fe\u5b9f\u7684\u7406\u7531\u3067\u3059<\/li>\n<li>\u3067\u3082\u5b9f\u306f\uff0c<span style=\"color: #000080;\"><strong>PCV\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u771f\u306e\u512a\u52a3\u306f2022\u5e74\u3067\u3082\u6c7a\u7740\u304c\u3064\u3044\u3066\u3044\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li><span style=\"color: #333333;\">\u65e5\u672c\u3067\u306e<\/span><strong><span style=\"color: #ff0000;\">\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4\u306e\u6a19\u6e96\u6cbb\u7642\u306f\uff0c\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5<\/span><\/strong>\u3068\u8a00\u3048\u307e\u3059<\/li>\n<li>\u5316\u5b66\u7642\u6cd5\u306f\u898b\u305f\u76ee\u3082\u6709\u52b9\u3067\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u5b8c\u5168\u306b\u6d88\u3048\u305f\u308a\u306f\u3057\u307e\u305b\u3093\u3057\uff0c\u304b\u306a\u308a\u983b\u5ea6\u3067\u518d\u767a\uff08\u518d\u71c3\uff09\u3057\u307e\u3059<\/li>\n<li>\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3092\u907f\u3051\u308b\u305f\u3081\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u306a\u3044\u3067\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3092\u3059\u308b\u3068\u3044\u3046\u9078\u629e\u80a2\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u751f\u5b58\u671f\u9593\u304c\u77ed\u304f\u306a\u308b\u6050\u308c\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3068\u3066\u3082\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u306f\uff0c<span style=\"color: #000080;\"><strong>\u5316\u5b66\u7642\u6cd5\u3060\u3051\u3067\u6cbb\u7652\u3059\u308b\u3053\u3068\u306f\u304b\u306a\u308a\u5c11\u306a\u3044<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u3092\u77e5\u3063\u3066\u304a\u304f\u3053\u3068\u3067\u3059<\/li>\n<li>\u624b\u8853\u3060\u3051\u3067\u304d\u308b\u75c5\u9662\u3067\u6cbb\u7642\u3067\u304d\u308b\u75be\u60a3\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3089\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306a\u3069\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u4e88\u60f3\u3055\u308c\u305f\u6642\u306b\u306f\u5c11\u306a\u304f\u3068\u3082\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u3067\u304d\u308b\u75c5\u9662\u3067\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u3087\u3046<\/li>\n<li><span style=\"color: #333333;\">\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u30b5\u30a4\u30d0\u30fc\u30ca\u30a4\u30d5\u306a\u3069\u306e\u5b9a\u4f4d\u5c11\u5206\u5272\u653e\u5c04\u7dda\u6cbb\u7642\u3088\u308a\u306f<\/span><strong><span style=\"color: #ff0000;\">\u5f93\u6765\u306e\u591a\u5206\u5272\u7167\u5c04<\/span><\/strong>\u3092\u4f7f\u3046\u3079\u304d\u3067\u3059<\/li>\n<li>\u5927\u304d\u306a\u816b\u760d\u306e\u5834\u5408\uff0c\u653e\u5c04\u7dda\u969c\u5bb3\u3092\u5c11\u306a\u304f\u3059\u308b\u305f\u3081\u306b\u306fIMRT\u3068\u3044\u3046\u7167\u5c04\u65b9\u6cd5\u304c\u512a\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c9\uff13\u3078\u306e\u653e\u5c04\u7dda\u306e\u91cf\u306f59.4\u30b0\u30ec\u30a4\u3068\u3044\u3046\u306e\u304c\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u653e\u5c04\u7dda\u306b\u3088\u308b\u8133\u969c\u5bb3\u3082\u304b\u306a\u308a\u5f37\u304f\u51fa\u307e\u3059<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u8a8d\u77e5\u6a5f\u80fd\u3092\u4fdd\u3064\u305f\u3081\u306b\u30b0\u30ec\u30fc\u30c9\uff13\u306b\u306f54\u30b0\u30ec\u30a4\u7a0b\u5ea6<\/strong><\/span>\u3092\u4f7f\u7528\u3057\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3057\u3087\u3046<\/li>\n<\/ul>\n<h5>\u518d\u767a\u3057\u305f\u6642<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20785\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1-300x298.jpg\" alt=\"\" width=\"300\" height=\"298\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1-300x298.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1-550x545.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1-768x762.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt1.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><a href=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20786\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2-300x295.jpg\" alt=\"\" width=\"300\" height=\"295\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2-300x295.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2-550x541.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2-768x755.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt2.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u53f3\u524d\u982d\u8449\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c9\uff12\u3067\u3059\u300246\u30b0\u30ec\u30a4\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6cbb\u7642\u3067\u843d\u3061\u7740\u3044\u3066\u3044\u307e\u3057\u305f\u3002\u53f3\u5074\u306f\u521d\u56de\u6cbb\u7642\u5f8c12\u5e74\u76ee\u306e\u518d\u767a\u3067\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-20787\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3-300x300.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3-550x552.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3-768x771.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligodtt3.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/>\n\u3068\u3066\u3082\u9650\u5c40\u6027\u306e\u518d\u767a\u3067\u3057\u305f\u306e\u3067\uff0c\u958b\u982d\u624b\u8853\u3067\u5168\u6458\u51fa supratotal resection \u3057\u307e\u3057\u305f\u3002<br \/>\n\u30aa\u30ea\u30b4\u306b\u306f\uff0c\u6d78\u6f64\u6027\u3067\u306f\u306a\u304f\u3066\uff0c\u8868\u9762\u7684\u3067\u9650\u5c40\u6027\u306e\u518d\u767a\u3082\u591a\u3044\u3067\u3059\u3002\u3067\u3082\u591a\u5c11\u306f\u6d78\u6f64\u3057\u3066\u3044\u308b\u306e\u3067\uff0c\u518d\u5ea6\u306e\u518d\u767a\u306e\u53ef\u80fd\u6027\u306f\u6b8b\u308a\u307e\u3059\u3002<\/p>\n<hr \/>\n<h1><a href=\"\/sawamura\/glioma\/oligodendrogliomacasepatho\/\">\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u75c7\u4f8b\u3068\u75c5\u7406\u306f\u5225\u30da\u30fc\u30b8\u306b\u3042\u308a\u307e\u3059\uff08\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\uff09<\/a><\/h1>\n<div class=\"setumei\">\n<hr \/>\n<\/div>\n<div class=\"setumei\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-10142 size-thumbnail\" src=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlalone-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlalone-1-200x200.jpg 200w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owlalone-1-144x144.jpg 144w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<\/div>\n<hr \/>\n<h3>\u3053\u3053\u304b\u3089\u4e0b\u306f\u5c02\u9580\u533b\u5411\u3051<\/h3>\n<div class=\"setumei\">\n<h4>\u7d44\u7e54\u8a3a\u65ad\u3068\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u77db\u76fe\u3057\u305f\u3089\u3069\u3046\u3059\u308b\u304b\uff1f<\/h4>\n<ul>\n<li>\u7d44\u7e54\u8a3a\u65ad\u3067\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3055\u308c\u3066\u3082\uff0c\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067 IDH, ATRX, TP53\u5909\u7570\u304c\u3042\u308a\uff0c\u304b\u30641p\/19q\u6b20\u5931\u304c\u306a\u304b\u3063\u305f\u3089<\/li>\n<li>\u3053\u306e\u8a3a\u65ad\u306f\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b diffuse astrocytoma, IDH-mutant\u3068\u306a\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">the genotype trumps the histological diagnosis<\/span><\/strong>\u3060\u305d\u3046\u3067\u3059<\/li>\n<li>trump\u3068\u3044\u3046\u306e\u306f\u5965\u306e\u624b\u3092\u51fa\u3057\u3066\u52dd\u3064\u3068\u3044\u3046\u610f\u5473\u3067\u3059<\/li>\n<li>\u5149\u93e1\u75c5\u7406\u3067\u30aa\u30ea\u30b4\u3067\u3082\uff0c\u6700\u7d42\u8a3a\u65ad\u306f\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3068\u306a\u308b\u306e\u3067\u3059<\/li>\n<li>\u5c0f\u5150\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\uff0cIDH mutation\u304c\u306a\u304f1p\/19q codeletion\u304c\u3042\u308b\u306e\u306f\uff0coliogodendroglioma, NOS\u3067\u3059<\/li>\n<\/ul>\n<\/div>\n<div class=\"setumei\">\n<h4 class=\"style1\"><strong>2016\u5e74WHO\u5206\u985e\uff08\u53e4\u3044\u3051\u3069\u91cd\u8981\u306a\u5909\u66f4\u70b9\uff09<\/strong><\/h4>\n<\/div>\n<div class=\"setumei\">\n<ul>\n<li>2007\u5e74\u306b\u520a\u884c\u3055\u308c\u305fWHO\u306e\u65b0\u5206\u985e\u3067\u306f\uff0cmixed gliomas\uff08\u6df7\u5408\u6027\u795e\u7d4c\u81a0\u816b\uff09\u306f\u5ec3\u6b62\u3055\u308c\uff0coligoastrocytic tumors\uff08\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u7cfb\u816b\u760d\uff09\u3068\u8a18\u8f09\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>anaplastic oligoastrocytoma\u306b\u58ca\u6b7b\u50cf\u3092\u542b\u3080\u816b\u760d\u306b\u95a2\u3057\u3066\u306f\uff0cglioblastoma\u306e\u7bc4\u7587\u306b\u5165\u308b\u3053\u3068\u3068\u306a\u308a\uff0c glioblastoma with oligodendroglioma component WHO grade 4\u3068\u8a18\u8ff0\u3057\u307e\u3057\u305f<\/li>\n<li>Miller\u3089\u306e\u5831\u544a\u306b\u3088\u308c\u3070\uff0c215\u4f8b\u306eanaplastic oligoastrocytoma\u306e\u4e2d\u306b\u306f33%\u306b\u58ca\u6b7b\u50cf\u304c\u898b\u3089\u308c\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\u58ca\u6b7b\u304c\u3042\u308b\u3082\u306e\u306723\u30f6\u6708\uff0c\u58ca\u6b7b\u304c\u306a\u3044\u3082\u306e\u3067\u306f87\u30f6\u6708\u3067\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306b\u57fa\u3065\u3044\u3066WHO\u5206\u985e\u306f\uff0c\u3053\u306e\u816b\u760d\u3092oligoastrocytoma grade IV\u3068\u306f\u305b\u305a\u306b\uff0cglioblastoma with oligodendroglial component\u3068\u3057\u3066astrocytic tumor\u306b\u542b\u3081\u307e\u3057\u305f<\/li>\n<li>\u6975\u3081\u3066\u7169\u96d1\u3067\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u306f\uff0canaplastic oligodendroglioma\u306f\u58ca\u6b7b\u50cf\u3092\u542b\u3093\u3067\u3082\u751f\u547d\u4e88\u5f8c\u306f\u60aa\u304f\u306f\u306a\u3089\u306a\u3044\u306e\u3067\u305d\u306e\u307e\u307egrade 3\u3068\u3055\u308c\u305f\u3053\u3068\u3067\u3059<\/li>\n<li>\u3053\u308c\u3089\u306e\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306f\uff0c\u60a3\u8005\u3055\u3093\u306e\u751f\u547d\u4e88\u5f8c\u4e88\u60f3\u3068\u6cbb\u7642\u306eintensity\u306e\u9078\u629e\u306b\u76f4\u7d50\u3059\u308b\u305f\u3081\u6975\u3081\u3066\u91cd\u8981\u3067\u3057\u305f<\/li>\n<li>\u3057\u304b\u3057\uff0c\u5f93\u6765\u3088\u308a\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760d\u3068\u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e\u9451\u5225\u8a3a\u65ad\u306b\u306f\u5927\u304d\u306a\u6df7\u4e71\u304c\u751f\u3058\u3066\uff0c\u5b9f\u969b\u306e\u81e8\u5e8a\u306e\u5834\u306b\u304a\u3044\u3066\u3053\u308c\u3089\u306e\u75c5\u7406\u8a3a\u65ad\u304c\u6b63\u78ba\u306b\u5224\u5b9a\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u7591\u554f\u304c\u6b8b\u308a\u307e\u3057\u305f<\/li>\n<li>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u50cf\u3092\u542b\u3080\u6d78\u6f64\u6027\u795e\u7d4c\u81a0\u816b\u306f\uff0c\u75c5\u7406\u50cf\u306b\u3088\u3063\u3066\u4e88\u5f8c\u306b\u3042\u307e\u308a\u306b\u5927\u304d\u306a\u5dee\u7570\u304c\u3042\u308b\u816b\u760d\u7fa4\u3067\u3042\u308b\u3053\u3068\u3092\u8a8d\u8b58\u3057\u3066\uff0c\u75c5\u7406\u8a3a\u65ad\u306b\u306f\u614e\u91cd\u306b\u5bfe\u51e6\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093<\/li>\n<li>2016\u5e74\u304b\u3089\u306f\uff0c1p\/19q\u6b20\u5931\u3092\u3082\u3063\u3066\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760d\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u3067\u3082\uff0c\u30b0\u30ec\u30fc\u30c9\uff08\u60aa\u5236\u5ea6\uff09\u306f\uff0c\u65e7\u6765\u306e\u7d44\u7e54\u8a3a\u65ad\u3067\u6c7a\u5b9a\u3055\u308c\u308b\u306e\u3067\uff0c\u75c5\u7406\u7d44\u7e54\u8a3a\u65ad\u306e\u5909\u9077\u3092\u3057\u308b\u3053\u3068\u306f\u4eca\u3060\u306b\u91cd\u8981\u3067\u3059\u3002<\/li>\n<\/ul>\n<\/div>\n<h4>\u751f\u691c\u8853\u306e\u7d50\u679c\u5224\u65ad\u304c\u96e3\u3057\u3044<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-7413 size-medium\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty2-300x281.jpg\" alt=\"oligoastroty1\" width=\"300\" height=\"281\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty2-300x281.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty2-550x516.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty2.jpg 1181w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-7414\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty1-300x285.jpg\" alt=\"oligoastroty2\" width=\"300\" height=\"285\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty1-300x285.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty1-550x522.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/oligoastroty1.jpg 1181w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u540c\u3058\u60a3\u8005\u3055\u3093\u304b\u3089\u306e2\u30ab\u6240\u306e\u75c5\u7406\u6a19\u672c\u3067\u3059\u3002\u5de6\u306f\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c92\u3068\u8a3a\u65ad\u3067\u304d\u307e\u3059\u3057\uff0c\u53f3\u306f\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\u3068\u8a3a\u65ad\u3067\u304d\u307e\u3059\u3002\u5149\u9855\u8a3a\u65ad\u3067\u306f\uff0c\u4e21\u65b9\u5408\u308f\u305b\u3066\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u30b0\u30ec\u30fc\u30c93\u3068\u306a\u308a\u307e\u3059\u3002\u3061\u306a\u307f\u306b\uff0colig2 \u5f37\u967d\u6027\uff0cMIB-1 9%\uff0c1p\/19q codeletion\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u8a3a\u65ad\u3092\u52a0\u3048\u308b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u306a\u308a\u307e\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u3067\u306f\uff0c\u8853\u4e2d\u8fc5\u901f\u75c5\u7406\u8a3a\u65ad\u3084\u5b9a\u4f4d\u8133\u751f\u691c\u8853\u3067\u306e\u8a3a\u65ad\u306f\u8aa4\u8a3a\u3092\u62db\u304f\u3053\u3068\u304c\u591a\u304f\u3066\u5371\u967a\u3067\u3059\u3002<\/p>\n<h5><strong>dual genotype oligoastrocytoma<\/strong><br \/>\n\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u661f\u7d30\u80de\u816b\u304c\u672c\u5f53\u306b\u6df7\u3058\u308b\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u304c\u3042\u308b\u304b<\/h5>\n<p>IDH mutant glioma\u306b, <em>TP53<\/em>\/<em>ATRX<\/em>-mutant, 1p\/19q-intact\u306eastrocytoma\u3068<em>ATRX<\/em>-wildtype, 1p\/19q-codeleted \u306eoligodendroglioma\u304c\u6df7\u3058\u308b\u3082\u306e\u304c\u7a00\u306b\u3042\u308a\u307e\u3059<\/p>\n<h4>\u75c5\u7406\u8a3a\u65ad\u306e\u5909\u9077<\/h4>\n<ul>\n<li>\u53e4\u304f\u306fKernohan\u306e\u5206\u985e (Kernohan 1949)<\/li>\n<li>Daumas-Duport\u306e\u5206\u985e (Daumas-Duport 1989)<\/li>\n<li>1979\u5e74WHO\u5206\u985e (Zulch 1979) \u306f\uff0c\u7d44\u7e54\u5b66\u7684\u306a\u60aa\u6027\u5ea6\u3092grade 1\uff5e4\u306b\u5206\u3051\u3066\u8b70\u8ad6\u3055\u308c\u305f\u307e\u3057\u305f<\/li>\n<li>\u304b\u3064\u3066\u5074\u8133\u5ba4\u5185\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3055\u308c\u305f\u3082\u306e\u306f\uff0c\u795e\u7d4c\u7d30\u80de\u8d77\u6e90\u306e\u4e2d\u67a2\u6027\u795e\u7d4c\u7d30\u80de\u816b (central neurocytoma)\u3067\u3059<\/li>\n<li>2007\u5e74WHO\u5206\u985e\u306f\uff0cgrade 2\u3068grade 3\u306b\u5206\u985e\u3057grade 4\u306f\u524a\u9664\u3055\u308c\u307e\u3057\u305f<\/li>\n<li>\u3055\u3089\u306b2016\u5e74WHO\u5206\u985e\u3067\u306f\uff0c\u7b2c\uff11\u67d3\u8272\u4f53\u77ed\u8155\u3068\u7b2c19\u67d3\u8272\u4f53\u9577\u8155\u306e\u6c7a\u5931 (1p\/19q codeletion) \u306e\u6709\u7121\u3067\u8a3a\u65ad\u3055\u308c\u307e\u3059<\/li>\n<li>\u3053\u306e\u6642\uff0c\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u304c\u524a\u9664\u3055\u308c\u307e\u3057\u305f<\/li>\n<\/ul>\n<h4>\u30b0\u30ec\u30fc\u30c9\uff12\u3068\uff13\u306e\u9055\u3044<\/h4>\n<ul>\n<li><strong>2<span style=\"color: #000080;\">022\u5e74\u6642\u70b9\u3067\uff0c\u30b0\u30ec\u30fc\u30c92\u30683\u306e\u9055\u3044\u306f\uff0c\u5149\u9855\u7d44\u7e54\u8a3a\u65ad<\/span><\/strong>\u306b\u3088\u308a\u307e\u3059<\/li>\n<li>\u6240\u898b\u3068\u3057\u3066\u306f\uff0cincreased cellularity, marked atypia, greater mitotic activity \u22652.5\u00a0mitoses\/mm<sup>2<\/sup>, microvascular proliferation, and necrosis with or without palisading<\/li>\n<li>\u305d\u308c\u3067\u3082\u30b0\u30ec\u30fc\u30c9\u5224\u65ad\u306b\u8ff7\u3063\u305f\u3089\uff0cMIB-1 index (Ki-67 immunostaining) \u3068\u81e8\u5e8a\u50cf\uff08\u7d4c\u904e\u304c\u65e9\u3044\u3068\u304bMRI\u3067\u306e\u60aa\u6027\u50cf\u3068\u304b\uff09\u3092\u53c2\u8003\u3068\u3057\u307e\u3059\u304c\uff0c\u5883\u754c\u306f\u832b\u6f20\u3068\u3057\u305f\u3082\u306e\u3067\u30dc\u30fc\u30c0\u30fc\u30e9\u30a4\u30f3\u30b1\u30fc\u30b9\u3082\u591a\u3044\u3067\u3059<\/li>\n<li>\u30d6\u30ec\u30fc\u30c9 3\u306e\u816b\u760d\u306e\u5927\u90e8\u5206\u306e\u7d44\u7e54\u50cf\u304c\u30b0\u30ec\u30fc\u30c9 2\u3067\u3042\u308b\u3068\u3044\u3046\u4f8b\u306f\u591a\u304f\uff0c\u30b0\u30ec\u30fc\u30c9 2\u3068\u3057\u3066\u9577\u304f\u5b58\u5728\u3057\u305f\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u304c\u60aa\u6027\u5316\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059<\/li>\n<\/ul>\n<h4>\u90e8\u5206\u50cf\u3060\u3051\u3067\u306f\u661f\u7d30\u80de\u7cfb\u816b\u760d\u3068\u898b\u5206\u3051\u306f\u3064\u304b\u306a\u3044<\/h4>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOAhe1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-3014\" title=\"AOAhe\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOAhe1-550x429.jpg\" alt=\"\" width=\"550\" height=\"429\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOAhe1-550x429.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOAhe1-300x234.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOAhe1.jpg 567w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>\u3053\u306e\u90e8\u5206\u306e\u307f\u3092\u4e00\u898b\u3059\u308b\u3068anaplastic astrocytoma\u3067\u3059\u3002\u3057\u304b\u3057\uff0c\u4ed6\u306e\u5927\u90e8\u5206\u304coligoastrocytoma\u3067\u3042\u308a\uff0c\u304b\u3064\u3066\u306e\u7d44\u7e54\u8a3a\u65ad\u3067\u306fanaplastic oligoastrocytoma AOA WHO grade III\u3067\u3059\u3002<\/p>\n<div class=\"setumei\">\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOhe.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-3011\" title=\"AOhe\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOhe-300x234.jpg\" alt=\"\" width=\"300\" height=\"234\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOhe-300x234.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOhe-550x429.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOhe.jpg 567w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOnecrosis.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-3012\" title=\"AOnecrosis\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOnecrosis-300x233.jpg\" alt=\"\" width=\"300\" height=\"233\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOnecrosis-300x233.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOnecrosis-550x428.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/AOnecrosis.jpg 1179w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u5de6\u5074\u306e\u75c5\u7406\u50cf\u306fanaplastic oligodendroglioma AO \u3042\u308b\u3044\u306foligodendroglioma OD\u3067\u3059\u3002\u3057\u304b\u3057\uff0c\u53f3\u306e\u753b\u50cf\u306e\u69d8\u306bpseudopallisading (necrosis)\u3092\u793a\u3059\u90e8\u5206\u304c\u3042\u308a\uff0cWHO grade 4\u3068\u8a3a\u65ad\u3057\u305f\u304f\u306a\u308b\u306e\u3067\u3059\u304c\uff0coligodendrglioma grade 3 \u3067\u306fnecrosis\u304c\u6df7\u5728\u3057\u3066\u3082grade 3\u3068\u3057\u3066\u3088\u3044\u306e\u3067\u3059\u3002<\/p>\n<h4>\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306e\u75ab\u5b66<\/h4>\n<p>\u6b27\u7c73\u304b\u3089\u306e\u5831\u544a\u3067\u306f\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u3092\u3042\u308f\u305b\u3066\u3082\uff0c\u539f\u767a\u6027\u8133\u816b\u760d\u306e\u5185\u3067\uff14\uff5e\uff15%\u7a0b\u5ea6\u306e\u6bd4\u8f03\u7684\u307e\u308c\u306a\u816b\u760d\u3068\u3055\u308c\u307e\u3059\u3002Norway\u3067\u306e25\u5e74\u9593\u306b\u308f\u305f\u308b\u8abf\u67fb(1953\u5e74\uff5e1977\u5e74)\u3067\u306f\uff0c208\u4f8b\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u767b\u9332\u3055\u308c\uff0c\u539f\u767a\u6027\u8133\u816b\u760d\u306e\u3046\u30614.2%\u3092\u5360\u3081\u305f\u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u30022009\u5e74\u306eDenmark\u304b\u3089\u306e\u5831\u544a\u3067\u306f\u3001\u4eba\u53e310\u4e07\u306b\u5bfe\u3057\u30660.4\u4f8b\u307b\u3069\u306e\u767a\u751f\u7387\u3067\u3042\u308a\u3001\u7537\u5973\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\n\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u5e74\u9f62\u5206\u5e03\u306f20\uff5e50\u6b73\u4ee3\u306b\u591a\u304f\uff0c40\u6b73\u4ee3\u306b\u30d4\u30fc\u30af\u304c\u3042\u308b\u6210\u4eba\u306e\u816b\u760d\u3067\u3059\u3002\u60aa\u6027\u578b\u306f\u4e2d\u9ad8\u5e74\u5c64\u306b\u591a\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u7537\u5973\u6bd4\u306f\u307b\u307c\u540c\u6570\u3067\u3059\u3002\u767a\u751f\u90e8\u4f4d\u306f\u524d\u982d\u8449\uff0c\u5074\u982d\u8449\uff0c\u982d\u9802\u8449\uff0c\u5f8c\u982d\u8449\u3068\u5927\u8133\u534a\u7403\u306e\u8868\u5c64\u90e8\u306b\u591a\u304f\uff0c\u7279\u306b\u524d\u982d\u8449\u306b\u597d\u767a\u3057\u307e\u3059\u3002\u304d\u308f\u3081\u3066\u7a00\u306b\u306f\u9593\u8133\u3084\u8133\u5e79\u90e8\uff0c\u5c0f\u8133\u3042\u308b\u3044\u306f\u810a\u9ac4\u306b\u307f\u3089\u308c\u307e\u3059\u3002\u661f\u7d30\u80de\u816b\u7cfb\u816b\u760d\u3068\u7570\u306a\u308a\uff0c\u4e00\u5074\u5927\u8133\u534a\u7403\u306b\u3068\u3069\u307e\u308b\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306e\u9ac4\u6db2\u64ad\u7a2e\u306f\u4ed6\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u7570\u306a\u308a\u304d\u308f\u3081\u3066\u7a00\u3067\u3059\u3002Norway\u304b\u3089\u306e\u5831\u544a\u3067\u306f\uff0c208\u4f8b\u4e2d\u306e\uff12\u4f8b\u306b\u9ac4\u6db2\u64ad\u7a2e\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u5916\u3078\u306e\u8ee2\u79fb\u306f\u4f8b\u5916\u7684\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n<h4>\u624b\u8853<\/h4>\n<p>\u75c5\u7406\u7d44\u7e54\u50cf\u3067\u8a8d\u3081\u3089\u308c\u308b\u7279\u6027\u3068\u3057\u3066\uff0c\u5468\u8fba\u8133\u7d44\u7e54\u3068\u304f\u306b\u5468\u8fba\u76ae\u8cea\u5185\u306e\u795e\u7d4c\u7d30\u80de\u5468\u56f2\uff0c\u8840\u7ba1\u5468\u56f2\uff0c\u8edf\u819c\u4e0b\u3078\u3068\u6d78\u6f64\u6027\u683c\u3092\u793a\u3057\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u6d78\u6f64\u80fd\u306f\u661f\u7d30\u80de\u816b\u3088\u308a\u306f\u4f4e\u304f\uff0c\u9ad8\u5206\u5316\u578b\u306e\u3082\u306e\u3067\u306f\u9650\u5c40\u6027\u3067\u6642\u306b\u5168\u6458\u51fa\u3082\u53ef\u80fd\u3067\u3059\u3002\u9ad8\u5206\u5316\u578b\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u306f\u672c\u6765\u4e88\u5f8c\u304c\u826f\u597d\u306a\u816b\u760d\u3067\u3042\u308a\uff0c\u307e\u305f\u4e00\u65b9\uff0c\u9000\u5f62\u6210\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\u306f\u8853\u5f8c\u306e\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3082\u6709\u52b9\u3067\u3059\u304b\u3089\uff0c\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u795e\u7d4c\u8131\u843d\u75c7\u72b6\u3092\u304d\u305f\u3059\u3088\u3046\u306a\u7121\u7406\u306a\u624b\u8853\u306f\u3057\u307e\u305b\u3093\u3002<\/p>\n<p>\u816b\u760d\u306f\uff0c\u6b63\u5e38\u8133\u7d44\u7e54\u3088\u308a\u3084\u3084\u5f3e\u6027\u304c\u3042\u308b\u304c\u67d4\u3089\u304b\u304f\u51fa\u8840\u306b\u4e4f\u3057\u3044\u3067\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u5927\u304d\u3055\u306e\u77f3\u7070\u5316\u3092\u542b\u3080\u305f\u3081\u306b\uff0c\u786c\u304f\u3056\u3089\u3056\u3089\u3068\u3057\u305f\u90e8\u5206\u3084\uff0c\u30b4\u30e0\u306e\u3088\u3046\u306b\u7c98\u308a\u6c17\u304c\u5f37\u3044\u90e8\u5206\u3082\u3042\u308a\u307e\u3059\u3002\u8089\u773c\u7684\u306b\u306f\u816b\u760d\u4e2d\u6df1\u90e8\u3067\u306f\u7070\u767d\u8272\u304b\u3089\u8584\u3044\u8910\u8272\u8abf\u3092\u5448\u3057\uff0c\u58ca\u6b7b\u3084\u816b\u760d\u5185\u51fa\u8840\u3092\u307f\u308b\u3053\u3068\u306f\u307e\u308c\u3067\u3059\u3002\u816b\u760d\u306e\u5883\u754c\u90e8\u3067\u306f\u767d\u8cea\u306b\u8fd1\u3044\u767d\u8272\u3068\u306a\u308a\u6b63\u5e38\u8133\u7d44\u7e54\u3068\u306e\u5224\u5225\u304c\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u53ef\u80fd\u3067\u3042\u308c\u3070\u8089\u773c\u7684\u306b\u5168\u6458\u51fa\u3057\u305f\u307b\u3046\u304c\u751f\u547d\u4e88\u5f8c\u306f\u660e\u3089\u304b\u306b\u826f\u3044\u3067\u3059\u3002Mayo Clinic\u3067\u306e81\u75c7\u4f8b\u306e\u5206\u6790\u3067\u306f\uff0c\u5168\u6458\u51fa\u3055\u308c\u305f\u75c7\u4f8b\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c12.6\u5e74\u3067\u3042\u308a\uff0c\u8853\u5f8c\u6b8b\u5b58\u816b\u760d\u306e\u3042\u3063\u305f\u75c7\u4f8b\u3067\u306f4.9\u5e74\u3067\u3057\u305f\u3002Norway\u306e170\u75c7\u4f8b\u306e\u89e3\u6790\u3067\u306f\uff0c\u5168\u6458\u51fa\u304c\u884c\u308f\u308c\u305f\u75c7\u4f8b\u306e\u751f\u5b58\u5272\u5408\u306f\u6709\u610f\u306b\u826f\u597d\u3067\u3042\u3063\u305f\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u3066\u3093\u304b\u3093\u767a\u4f5c\u3067\u767a\u75c7\u3057\u305f\u4f8b\u3067\u306f\uff0c\u8853\u524d\u306e\u795e\u7d4c\u8131\u843d\u75c7\u72b6\u304c\u306a\u3044\u306e\u3067\u7279\u306b\u6ce8\u610f\u3092\u8981\u3057\u307e\u3059\u3002\u3044\u308f\u3086\u308b\u3066\u3093\u304b\u3093\u306e\u5916\u79d1\u306e\u3054\u3068\u304f\uff0c\u816b\u760d\u7d44\u7e54\u306e\u6458\u51fa\u3068\u3068\u3082\u306b\uff0c\u8853\u4e2d\u306e\u8133\u6ce2\u30e2\u30cb\u30bf\u30fc\u3092\u4f75\u7528\u3057\u3066\uff0c\u3066\u3093\u304b\u3093\u7126\u70b9\u306e\u9664\u53bb\u3092\u4e3b\u76ee\u7684\u3068\u3059\u308b\u624b\u8853\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u4e00\u65b9\u3067\uff0c\u9ad8\u5206\u5316\u578b\u816b\u760d\u3067\u306f\u816b\u760d\u306e\u307f\u3092\u6458\u51fa\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u6d88\u5931\u3092\u671f\u5f85\u3057\u5f97\u308b\u3068\u3044\u3046\u5831\u544a\u3084\uff0c\u816b\u760d\u306e\u6458\u51fa\u306e\u307f\u306b\u3068\u3069\u3081\u3066\u5468\u56f2\u306e\u6b63\u5e38\u8133\u8ffd\u52a0\u5207\u9664\u3092\u52a0\u3048\u306a\u3044\u307b\u3046\u304c\u6210\u7e3e\u304c\u3088\u3044\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305a\u306f\uff0c\u75c5\u5909\u5207\u9664 lesionectomy\u3092\u512a\u5148\u3057\u3066\uff0c\u521d\u56de\u624b\u8853\u3067\u306f\u3066\u3093\u304b\u3093\u6291\u5236\u3092\u4e3b\u76ee\u7684\u3068\u3057\u305f\u5e83\u6c4e\u5207\u9664\u306f\u907f\u3051\u307e\u3059\u3002\u73fe\u5b9f\u7684\u306b\uff0clesionectomy\u306e\u307f\u3067\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u5341\u5206\u53ef\u80fd\u3068\u306a\u308b\u30b1\u30fc\u30b9\u304c\u307b\u3068\u3093\u3069\u3067\u3059\u3002<\/p>\n<h4>\u5316\u5b66\u7642\u6cd5<\/h4>\n<p>\u4e4f\u7a81\u8d77\u81a0\u816b\u306f\u5316\u5b66\u7642\u6cd5\u611f\u53d7\u6027\u304c\u9ad8\u3044\u795e\u7d4c\u81a0\u816b\u3067\uff0cCCNU, BCNU, ACNU, procarbazine, carboplatin, vincristine, cisplatin, etoposide, melphalan, 5-fluorouracil, temozolomide\u306a\u3069\u304c\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u73fe\u5728\u7528\u3044\u3089\u308c\u308b\u5316\u5b66\u7642\u6cd5\u306f\u4ee5\u4e0b\u306e\u3082\u306e\u3067\uff0c\u5225\u30da\u30fc\u30b8\u306b\u8a73\u3057\u304f\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002<\/p>\n<h5 class=\"setumei\"><a href=\"\/sawamura\/glioma\/pcvchemotherapy\/\"><strong>PCV\u5316\u5b66\u7642\u6cd5\uff08\u30af\u30ea\u30c3\u30af\uff09<\/strong><\/a><\/h5>\n<\/div>\n<p class=\"setumei\">CCNU \u30ed\u30e0\u30b9\u30c1\u30f3 (100-130 mg\/m<sup>2<\/sup>\u00a0day 1\uff0c\u7d4c\u53e3\u6295\u4e0e)<br \/>\nVCR \u786b\u9178\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3 (1.4 mg\/m<sup>2<\/sup>\u00a0day 8 and day29\uff0c\u9759\u6ce8)<br \/>\nPCZ \u5869\u9178\u30d7\u30ed\u30ab\u30eb\u30d0\u30b8\u30f3\u30ab\u30d7\u30bb\u30eb (60-75 mg\/m<sup>2<\/sup>\u00a0days 8-21\u9023\u65e5\uff0c\u7d4c\u53e3\u6295\u4e0e)<\/p>\n<div class=\"setumei\">\n<h5><strong><a title=\"\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff09\" href=\"\/sawamura\/braintumors\/glioma\/temozolo\/\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff08\u30c6\u30e2\u30be\u30ed\u30df\u30c9\uff09\u5316\u5b66\u7642\u6cd5\uff08\u30af\u30ea\u30c3\u30af\uff09<\/a><\/strong><\/h5>\n<\/div>\n<div class=\"setumei\">\n<h5>\u6587\u732e\u60c5\u5831<\/h5>\n<h4>\u30b0\u30ec\u30fc\u30c9\uff12\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u65b9\u304c\u826f\u3044<\/h4>\n<p>Schiff D: LTBK-07. PROGRESSION-FREE AND OVERALL SURVIVAL RESULTS OF ECOG-ACRIN E3F05: A PHASE 3 INTERGROUP TRIAL OF RADIATION \u00b1 TEMOZOLOMIDE FOR GRADE II GLIOMAS. Neuro Oncol 2024<br \/>\n2024\u5e74\u672b\u306eSNO\u3067\u5831\u544a\u3055\u308c\u305f\u3068\u3066\u3082\u91cd\u8981\u306a\u767a\u8868\u3067\u3059\u3002\u81e8\u5e8a\u7b2c\uff13\u76f8\u7121\u4f5c\u70baE3FO5 trial\u306e\u7d99\u7d9a\u7d50\u679c\u3067\u3059\u3002172\u540d\u306e\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u3093\u3092\u6cbb\u7642\u5f8c\u306b10\u5e74\u4ee5\u4e0a\u7d4c\u904e\u89b3\u5bdf\u3057\u305f\u7d50\u679c\u3067\u3059\u3002\u521d\u671f\u6cbb\u7642\u3067\u653e\u5c04\u7dda\u6cbb\u764250.4Gy\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u3092\u884c\u306a\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\u306f10\u5e74\u751f\u5b58\u5272\u5408\u304c70\uff05\u306b\u5bfe\u3057\u3066\uff0c\u4f75\u7528\u3057\u306a\u304b\u3063\u305f\u7fa4\u3067\u306f47\uff05\u3067\u3057\u305f\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u304c\u30b0\u30ec\u30fc\u30c92\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u8cb4\u91cd\u306a\u5831\u544a\u3067\u3059\u3002\u3082\u3061\u308d\u3093\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u5bb3\u4e8b\u8c61\u3084\u7d4c\u6e08\u7684\u8eab\u4f53\u7684\u306a\u8ca0\u62c5\u306f\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u306e\u751f\u5b58\u5272\u5408\u306e\u5dee\u306f\u3068\u3066\u3082\u5927\u304d\u306a\u3082\u306e\u3067\u3059\u3002<br \/>\nDr Schiff\u306f\u91cd\u8981\u306a\u7d50\u679c\u3092\u542b\u3080\u3068\u7d9a\u3051\u307e\u3059\u3002\u306a\u3093\u3068\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u661f\u7d30\u80de\u816b\u3067\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u304c\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002\u666e\u901a\u306f\u3069\u3046\u8003\u3048\u3066\u3082\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u65b9\u304c\u306f\u308b\u304b\u306b\u826f\u3044\u6210\u7e3e\u306e\u306f\u305a\u3067\u3059\u304c\uff1f<\/p>\n<h4>\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u306f\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u983b\u5ea6\u3082\u4e0b\u3052\u308b<\/h4>\n<p class=\"text-[26px] font-medium leading-8\">Rosa K: Vorasidenib Shows Consistent Efficacy With Manageable Safety in IDH1\/2-Mutant Diffuse Glioma. 2024 Nov, SNO, Houston<br \/>\n\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib (Voranigo)\u306eINDIGO\u8a66\u9a13\u306e\u8ffd\u52a0\u5831\u544a\u3067\u3059\u3002\u5bfe\u8c61\u306fIDH1\/2-mutated diffuse glioma\uff08\u661f\u7d30\u80de\u816b\u3068\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u5165\u308a\u307e\u3059\uff09\u3002\u670d\u7528\u3057\u305f\u7fa4\u3067\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u767a\u75c7\u7387\u304c\u4f4e\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u307e\u305f\u670d\u7528\u7fa4\u3067\u816b\u760d\u306e\u4f53\u7a4d\u304c\u6e1b\u5c11\u3057\u305f\u306e\u306b\u5bfe\u3057\uff0c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u816b\u760d\u4f53\u7a4d\u304c\u5897\u5927\u3057\u307e\u3057\u305f\u30022023\u5e743\u6708\u306e\uff13\u56de\u76ee\u306e\u4e2d\u9593\u89e3\u6790\u3067\u306f\uff0c\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6\u7fa4\u306ePFS\u4e2d\u592e\u5024\u306f\u3055\u3089\u306b\u5ef6\u3073\u3066\u307e\u3060\u8a55\u4fa1\u3067\u304d\u305a\uff0c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f11.4\u30f6\u6708\u3067\u3057\u305f\u3002\u660e\u3089\u304b\u306a\u6709\u610f\u5dee\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<h4><span class=\"title_default\">\u30dc\u30e9\u30b7\u30c7\u30cb\u30d6 vorasidenib\u306f\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u661f\u7d30\u80de\u816b\u3068\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\uff1a\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u306e\u7d50\u679c<\/span><\/h4>\n<p>Mellinghoff IK:\u00a0<span class=\"title_default\">Vorasidenib in IDH1- or IDH2-mutant low-Grade glioma. New Engl J Med 2023<br \/>\nvorasidenib\u306f\u3001\u5909\u7570\u578bIDH1\/2\u9175\u7d20\u306e\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3001\u816b\u760d\u306e2-\u30d2\u30c9\u30ed\u30ad\u30b7\u30b0\u30eb\u30bf\u30eb\u9178\uff082-HG\uff09\u309290\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u7d4c\u53e3\u85ac\u3067\u3059\u304c\u8133\u5185\u79fb\u884c\u304c\u3088\u3044\u85ac\u5264\u3067\u3059\u3002\u8853\u5f8c\u306e\u6b8b\u5b58\u816b\u760d\u3042\u308b\u3044\u306f\u518d\u71c3 168\u4f8b\u306bvorasidenib (40 mg once daily) \u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u502414.2\u30f6\u6708\u306e\u6642\u70b9\u3067\uff0c7\u5272\u306e\u60a3\u8005\u3055\u3093\u304cvorasidenib\u3042\u308b\u3044\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u7d99\u7d9a\u670d\u7528\u3057\u3066\u3044\u307e\u3057\u305f\u3002<span style=\"color: #ff0000;\"><strong>PFS\u4e2d\u592e\u5024\u306f\uff0cvorasidenib\u306727.7\u30f6\u6708\uff0c\u30d7\u30e9\u30bb\u30dc\u306711.1\u30f6\u6708<\/strong><\/span>\u3067\u3057\u305f\u3002\u30b0\u30ec\u30fc\u30c93\u4ee5\u4e0a\u306e\u6709\u5bb3\u4e8b\u8c61\u306f22.8%\u3067\u307f\u3089\u308c\uff0cALT\u306e\u4e0a\u6607\u304c\u76ee\u7acb\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u4e2d\u6b62\u306f3.6%\u3067\u3057\u305f\u3002<\/span><\/p>\n<\/div>\n<div class=\"article-citation\">\n<h4>\u521d\u671f\u6cbb\u7642\u3068\u3057\u3066\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068PCV\u5316\u5b66\u7642\u6cd5\u306f\u6709\u52b9\u6027\u304c\u9ad8\u3044<\/h4>\n<\/div>\n<p class=\"heading-title\"><span class=\"authors-list-item \">Lassman AB:\u00a0<\/span>Joint Final Report of EORTC 26951 and RTOG 9402: Phase III Trials With Procarbazine, Lomustine, and Vincristine Chemotherapy for Anaplastic Oligodendroglial Tumors. \u00a0J Clin Oncol 2022<br \/>\n\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u5171\u540c\u7814\u7a76\u3067\u4f55\u5ea6\u3082\u767a\u8868\u3055\u308c\u3066\u304d\u305f\u3082\u306e\u306e\u6700\u7d42\u5831\u544a\u3068\u3044\u3046\u306e\u307f\u3067\u3059\u3002\u7d50\u8ad6\u306f\u5909\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u7d44\u7e54\u8a3a\u65ad\u304c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c93\u3067\u6cbb\u7642\u3092\u53d7\u3051\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f18-19\u30f6\u6708\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\u30672.6\u5e74\uff0cPCV\u3092\u52a0\u3048\u30663.5\u5e74\u3067\u3057\u305f\u300214\u5e74\u751f\u5b58\u5272\u5408\u306f13\uff05\u306825\uff05\uff0c20\u5e74\u751f\u5b58\u5272\u5408\u306f10%\u306817\uff05\u3067\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u304c\u958b\u59cb\u3055\u308c\u305f30\u5e74\u307b\u3069\u524d\u306b\u306f1p19q codeletion \u5171\u6b20\u5931\u304c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u8a3a\u65ad\u57fa\u6e96\u306b\u5165\u3063\u3066\u3044\u307e\u305b\u3093\u3002codel\u304c\u3042\u308b\u73fe\u5728\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c93\u306b\u9650\u3063\u3066\u8a55\u4fa1\u3092\u884c\u3046\u3068\uff0c\u305d\u308c\u305e\u308c9.3\u5e74\uff0c26%\uff0c14\uff05\uff0cPCV\u306714\u5e74\uff0c51\uff05\uff0c37\uff05\u3068\u306a\u308a\u307e\u3059\u3002<br \/>\n\u5316\u5b66\u7642\u6cd5\u3068\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c93\u306b\u304d\u3061\u3093\u3068\u884c\u3046\u3068\uff0c\u73fe\u5728\u3067\u306f14\u5e74\u4ee5\u4e0a\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c\u671f\u5f85\u3067\u304d\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u306e\u512a\u52a3\u306f\u3064\u3044\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<div class=\"inline-authors\">\n<div class=\"authors\"><\/div>\n<\/div>\n<div class=\"setumei\">\n<h4>\u653e\u5c04\u7dda\u91cf\u306f\u9ad8\u7dda\u91cf\u304b\u4f4e\u7dda\u91cf\u304b<\/h4>\n<p><span class=\"authors-list-item \">Breen WG:\u00a0<\/span>Final report from Intergroup NCCTG 86-72-51 (Alliance): a phase III randomized clinical trial of high-dose versus low-dose radiation for adult low-grade glioma. Neuro Oncol 2020<br \/>\nNCCTG-86-72-51\u306e\u6700\u7d42\u5831\u544a\u3067\u3059\u30021986\u5e74\u304b\u30891994\u5e74\u307e\u3067203\u4eba\u306elow-grade glioma (diffuse astroytoma, oilgodendroglioma, oligoastrocytoma) \u306e\u60a3\u8005\u3055\u3093\u304c\u7121\u4f5c\u70ba\u306b\uff0c50.4Gy (28\u5206\u5272) \u3042\u308b\u3044\u306f 64.8Gy (36\u5206\u5272) \u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u300225\u5e74\u306b\u53ca\u3076\u8ffd\u8de1\u8abf\u67fb\u306e\u7d50\u679c\u3067\u3059\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f5.2\u5e74\uff0c\u5168\u751f\u5b58\u671f\u9593\u306f8.4\u5e74\u3067\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f17.2\u5e74\u3067\uff0c33\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6700\u7d42\u89b3\u5bdf\u6642\u70b9\u3067\u751f\u5b58\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u9ad8\u7dda\u91cf\u7167\u5c04\u306f15\u5e74\u5168\u751f\u5b58\u5272\u5408\u3082\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408\u3082\u6539\u5584\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5168\u751f\u5b58\u671f\u9593\u306f\uff0c\u816b\u760d\u304c5cm\u672a\u6e80\u304b\u3064baseline MMSE27\u70b9\u4ee5\u4e0a\uff0c\u3082\u3057\u304f\u306f\u5168\u6458\u51fa GTR\u3067\u304d\u305f\u5834\u5408\u306b\u826f\u597d\u3067\u3057\u305f\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f\uff0c\u661f\u7d30\u80de\u816b\u3088\u308a\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u65b9\u304c\u826f\u304f\uff0c5cm\u672a\u6e80\uff0cMMSE 27\u4ee5\u4e0a\uff0c\u5168\u6458\u51fa\u3067\u304d\u305f\u4f8b\u3067\u826f\u597d\u3067\u3057\u305f\u3002baseline MMSE\u304c\u6b63\u5e38\u3067\u3042\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c7\u5e74\u5f8c\u306b1\u4f8b (5%) \u3067\u6709\u610f\u306aMMSE\u306e\u4f4e\u4e0b\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\n\u300c\u7d50\u8ad6\u300d\u9ad8\u7dda\u91cf\u7167\u5c04\u306b\u5229\u70b9\u306f\u3042\u308a\u307e\u305b\u3093\u3002MMSE\u3067\u898b\u308b\u9650\u308a\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e\u8a8d\u77e5\u6a5f\u80fd\u306fstable \uff08\u3042\u307e\u308a\u843d\u3061\u306a\u3044\u3068\u3067\u3082\u8a33\u3057\u307e\u3057\u3087\u3046\u304b\uff09\u3067\u3057\u305f\u3002<\/p>\n<div class=\"article-citation\">\n<h4>CDKN2A\u5171\u6b20\u5931\u306f\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u306e\u4e88\u5f8c\u4e0d\u826f\u56e0\u5b50<\/h4>\n<\/div>\n<p><span class=\"docsum-authors full-authors\">Appay R:\u00a0<\/span>CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse\u00a0malignant IDH-mutant gliomas. Neuro Oncol 2019<br \/>\nIDH\u5909\u7570\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c93\u304b4\u306e\u9ad8\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de911\u4f8b\u3067CDKN2A cyclin-dependent kinase inhibitor 2A\u306e\u6b20\u5931\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002\u7d44\u7e54\u8a3a\u65ad\u3067\u8a00\u3048\u3070\uff0c\u81a0\u82bd\u816bIDHmutant 216\u4f8b\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b 212\u4f8b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b 483\u4f8b\u3067\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u7d44\u7e54\u578b\u306b\u304a\u3044\u3066\uff0cCDKN2A\u304c\u3042\u308b\u3068\u4e88\u5f8c PFS, OS \u304c\u6709\u610f\u306b\u60aa\u3044\u3068\u306e\u7d50\u8ad6\u3067\u3059\u3002\u52a0\u3048\u3066\u75c5\u7406\u6240\u898b\u3067\u5fae\u5c0f\u8840\u7ba1\u5897\u6b96\u50cf microvascular proliferation\u304c\u3042\u308b\u3068\u4e88\u5f8c\u304c\u60aa\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u81a0\u82bd\u816b\u306f\u3068\u3082\u304b\u304f\uff0c\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u306f\u4e88\u5f8c\u306e\u5927\u304d\u304f\u9055\u3046\u7fa4\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u4e88\u5f8c\u5224\u5225\u306e\u76ee\u5b89\u3068\u306a\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u6349\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<h4>\u653e\u5c04\u7dda\u58ca\u6b7b\u306f\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\u751f\u3058\u3084\u3059\u3044\uff0c\u7279\u306b54\u30b0\u30ec\u30a4\u4ee5\u4e0a\u3092\u7528\u3044\u305f\u6642<\/h4>\n<p><span role=\"menubar\">Ahmad H: <span class=\"highlight\">Oligodendroglioma<\/span> confers higher risk of radiation necrosis. J Neurooncol.<\/span> 2019<br \/>\n319\u4f8b\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3067\uff0c\u653e\u5c04\u7dda\u58ca\u6b7b radiation necrosis \u306e\u983b\u5ea6\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\u306f21.3%\u306b\u653e\u5c04\u7dda\u58ca\u6b7b\u304c\u751f\u3058\u305f\u306e\u306b\u5bfe\u3057\uff0c\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3067\u306f6.9%\u3067\u3057\u305f\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u5bfe\u3057\u3066\uff0c54\u30b0\u30ec\u30a4\u3092\u8d85\u3048\u308b\u7dda\u91cf\u3092\u7528\u3044\u308b\u306831%\uff0c54\u30b0\u30ec\u30a4\u4ee5\u4e0b\u3067\u306f14\uff05\u3067\u653e\u5c04\u7dda\u58ca\u6b7b\u304c\u767a\u751f\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u30028\u5272\u3067\u7167\u5c04\u5f8c24\u30f6\u6708\u4ee5\u5185\u306b\u653e\u5c04\u7dda\u58ca\u6b7b\u304c\u751f\u3058\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u306e\u6709\u7121\u304c\u6b63\u78ba\u306b\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3067\u3082\u9577\u671f\u4e88\u5f8c\u3092\u8003\u3048\u305f\u6642\uff0c\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u306b54\u30b0\u30ec\u30a4\u3092\u8d85\u3048\u308b\u7dda\u91cf\u306f\u7528\u3044\u306a\u3044\u65b9\u304c\u3044\u3044\u306e\u3067\u3057\u3087\u3046\u3002<\/p>\n<h4 class=\"cit\">\u624b\u8853\u5f8c\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3092\u884c\u3046\u3079\u304d\u3067\u3042\u308b<\/h4>\n<p>Rud\u00e0 R: Efficacy of initial <span class=\"highlight\">temozolomide<\/span> for high-risk low grade gliomas in a phase II AINO (Italian Association for Neuro-Oncology) study: a post-hoc analysis within molecular subgroups of WHO 2016. <span role=\"menubar\">J Neurooncol.<\/span> 2019<br \/>\n\u30a4\u30bf\u30ea\u30a2\u3067\u306e\u5f8c\u65b9\u8996\u7684\u89e3\u6790\u7d50\u679c\u3067\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u30b0\u30ec\u30fc\u30c9\uff12\u3078\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u5f8c\u7642\u6cd5\u306e\u594f\u529f\u5272\u5408\u306f76%\uff0c\u75c7\u5019\u6027\u3066\u3093\u304b\u3093\u767a\u4f5c\u306e\u6d88\u5931\u306f72%\uff0c\u60a3\u8005\u3055\u3093\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3092\u53d7\u3051\u305f67%\u306e\u60a3\u8005\u3055\u3093\u306f\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50249.3\u5e74\u3067\u518d\u767a recurrence\u3057\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u3053\u306e\u8a71\u304c\u672c\u5f53\u306a\u3089PCV\u306e\u51fa\u308b\u5e55\u306f\u306a\u3055\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4 class=\"cit\">\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u304c\u30b0\u30ec\u30fc\u30c92\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u6cbb\u7642\u9078\u629e\u80a2\u3068\u306a\u308b\u304b\uff1f<\/h4>\n<p>Franceschi E: Postsurgical Approaches in Low-Grade <span class=\"highlight\">Oligodendroglioma<\/span>: Is Chemotherapy Alone Still an Option?\u00a0<span role=\"menubar\">Oncologist.<\/span> 2019<br \/>\n\u30a4\u30bf\u30ea\u30a2\u304b\u3089\u306e\u5831\u544a\u3067\u3042\u307e\u308a\u30ec\u30d9\u30eb\u306e\u9ad8\u3044\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u30822019\u5e74\u6642\u70b9\u3067\u591a\u304f\u306e\u795e\u7d4c\u816b\u760d\u533b\u306e\u8003\u3048\u3068\u3082\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u4e4f\u7a81\u8d77\u81a0\u816b (IDH mutant, 1p\/19q codel)93\u4eba\u306e\u60a3\u8005\u3055\u3093\u306e\u89e3\u6790\u3067\u3059\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024 PFS \u306f\uff0c\u624b\u8853\u5f8c\u3059\u3050\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u305f26\u4eba\u3067114\u30f6\u6708\uff0c\u53d7\u3051\u306a\u304b\u3063\u305f67\u4eba\u306747\u30f6\u6708\u3067\u3057\u305f\u3002<strong><span style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u3067\u306f\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577<\/span><\/strong>\u306f\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002PFS\u5ef6\u9577\u306e\u307f\u306a\u3089\u305a\uff0c\u6cbb\u7652\u5e0c\u671b\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u52a0\u3048\u308b\u3053\u3068\u304c\u8981\u6c42\u3055\u308c\u307e\u3059\u3002<\/p>\n<h4>\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f8c\u3067PCV\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3046: RTOG 9802\uff0810\u5e74\u4ee5\u4e0a\u306e\u7d4c\u904e\u3092\u898b\u305f\u5834\u5408\uff09<\/h4>\n<p>Buckner JC, et al: Radiation\u00a0plus\u00a0Procarbazine,\u00a0CCNU, and Vincristine in Low-Grade Glioma. N Engl J Med.\u00a02016<br \/>\n1998\u5e74\u304b\u30892002\u5e74\u306e\u9593\u306b<span style=\"color: #000080;\"><strong>\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u3042\u308b\u3044\u306f\u4e4f\u7a81\u8d77\u81a0\u816b<\/strong><\/span>\u306e251\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024 12\u5e74\u3068\u3044\u3046\u6c17\u306e\u9060\u304f\u306a\u308b\u307b\u3069\u306e\u9577\u3044\u89b3\u5bdf\u7d50\u679c\u3067\u3059\u300218\u6b73\u304b\u308939\u6b73\u3067\u751f\u691c\u8853\u3042\u308b\u3044\u306f\u90e8\u5206\u6458\u51fa subtotal resection\u3092\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\uff0c\u3042\u308b\u3044\u306f\u3069\u306e\u3088\u3046\u306a\u624b\u8853\u7d50\u679c\u3067\u308240\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f8c\u3067PCV\u7dad\u6301\u5316\u5b66\u7642\u6cd5\u304c\u52a0\u3048\u3089\u308c\u307e\u3057\u305f\u3002<span style=\"color: #000080;\"><strong>\u653e\u5c04\u7dda\u5358\u72ec\u3067\u306f\u5168\u751f\u5b58\u671f\u9593\u306f7.8\u5e74\uff0cPCV\u3092\u52a0\u3048\u308b\u306813.3\u5e74<\/strong><\/span>\u3068\u3044\u3046\u5927\u304d\u306a\u5dee\u304c\u51fa\u307e\u3057\u305f\u300210\u5e74\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408\u306f\u305d\u308c\u305e\u308c21%\u306851%\u3067\uff0c\u5168\u751f\u5b58\u5272\u5408\u3060\u306840%\u306860%\u3067\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u7d44\u7e54\u578b\u3067\u7121\u5897\u60aa\u751f\u5b58\u3082\u5168\u751f\u5b58\u5272\u5408\u3082\u9ad8\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502412\u5e74\u306755%\u306e\u60a3\u8005\u3055\u3093\u304c\u4ea1\u304f\u306a\u308a\u307e\u3057\u305f\u3002<br \/>\n\u300c\u89e3\u8aac\u300d\u3068\u3066\u3082\u6a29\u5a01\u306e\u9ad8\u3044\u96d1\u8a8c\u306b\u767a\u8868\u3055\u308c\u305f\u6cbb\u7642\u6210\u7e3e\u3067\u3059\u3002\u3053\u306e\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u306f1998\u5e74\u306b\u958b\u59cb\u3055\u308c\u3066\u304a\u308a\uff0c\u304b\u306a\u308a\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u6df7\u5728\u304c\u3042\u308a\u307e\u3059\u3002\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b 1p\/19q non-deleted\u3067\u771f\u3067\u3042\u308b\u304b\u3069\u3046\u304b\uff0c\u8b0e\u306e\u307e\u307e\u3067\u3057\u3087\u3046\u3002\u3067\u3082\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u304a\u3044\u3066\u306f\u771f\u306e\u7d50\u679c\u3068\u8a00\u3048\u307e\u3059\u3002\u6cbb\u7642\u5f8c\u306bPCV\u3092\u7d99\u7d9a\u3059\u308b\u306e\u306f\uff0c\u60a3\u8005\u3055\u3093\u306b\u306f\u3068\u3066\u3082\u8ca0\u62c5\u304c\u5927\u304d\u3044\u3068\u3082\u8a00\u3048\u307e\u3059\u3002<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u3069\u3061\u3089\u3092\u9078\u629e\u3059\u308b\u304b<\/h4>\n<p>Wick W, et al.: Long-term analysis of the NOA-04 randomized phase III trial of sequential\u00a0radiochemotherapy\u00a0of\u00a0anaplastic\u00a0glioma with PCV or temozolomide. Neuro Oncol 2016<br \/>\n\u30b0\u30ec\u30fc\u30c93\u306e\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u4e3b\u3068\u3057\u3066\u9000\u5f62\u6210\u6027\u661f\u7d30\u80de\u816b\uff0c\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\uff09318\u4f8b\u304c\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\uff0cPCV\u5316\u5b66\u7642\u6cd5\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u306e3\u7fa4\u306b\u5206\u985e\u3055\u308c\u3066\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u3092\u5358\u72ec\u52b9\u679c\u3092\u307f\u3066\u3044\u307e\u3059\u306e\u3067\uff0cfirst line\u3067\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u50249.5\u5e74\u306e\u6bb5\u968e\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u3068\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u7fa4\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f \u00a0TTF (4.6 y vs 4.4 y), PFS (2.5 y vs 2.7 y), and OS (8 y vs 6.5 y)\u3002\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068PCV\u306e\u9593\u306b\u306f\u82e5\u5e72\u306e\u5dee\u304c\u3042\u3063\u3066\uff0cCIMP-codel\u3064\u307e\u308a\uff0cIDH mutation\u30681p\/19 co-deletion\u306e\u3042\u308b\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u3067\u306f\uff0cPCV \u306e\u6709\u52b9\u6027\u304c\u9ad8\u304b\u3063\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u5c11\u6570\u6bd4\u8f03\u3067\u3059\u3002<\/p>\n<h4>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u3069\u3061\u3089\u304c QOL \u751f\u5b58\u306e\u8cea\u304c\u826f\u3044\u304b<\/h4>\n<p>Baumert BG: Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol, 2016<br \/>\nReijneveld JC: Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol, 2016<br \/>\n477\u4eba\u306e\u30b0\u30ec\u30fc\u30c9II\u30b0\u30ea\u30aa\u30fc\u30de\u00a0(astrocytoma, oligoastrocytoma, or oligodendroglioma)\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\u3067\u3059\u3002\u6cbb\u7642\u3092\u884c\u3063\u305f\u57fa\u6e96\u306f\u4e88\u5f8c\u304c\u60aa\u305d\u3046\u306b\u601d\u3048\u308b\u4f8b\u3067\uff0c40\u6b73\u4ee5\u4e0a\uff0c\u9032\u884c\u6027\u75c5\u5de3\uff0c\u816b\u760d\u30b5\u30a4\u30ba\u304c5cm\u4ee5\u4e0a\uff0c\u6b63\u4e2d\u3092\u8d85\u3048\u308b\u75c5\u5909\uff0c\u795e\u7d4c\u75c7\u72b6\u304c\u3042\u3063\u305f\u3068\u3044\u3046\u57fa\u6e96\u3067\u3059\u3002\u7121\u4f5c\u70ba\u306b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642 (conformal radiotherapy; up to 50.4 Gy; 28 doses of 1.8 Gy once daily)\u00a0\u3042\u308b\u3044\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u00a0(75 mg\/m2 for 21 days, every 28 days, maximum of 12 cycles)\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nPFS \u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7fa4\u306739\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u306746\u30f6\u6708\u3068\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\uff0c\u751f\u5b58\u306e\u8cea\u00a0health-related quality of life (HRQOL)\u306b\u3082\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u306f\u5168\u822c\u7684\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u6cbb\u7642\u7fa4\u3067\u591a\u3044\u3067\u3059\u3002<br \/>\n\u305f\u3060\u3057\uff0c<span style=\"color: #000080;\"><strong>IDH\u5909\u7570\u304c\u3042\u308a1p\/19q\u6b20\u5931\u304c\u306a\u3044\u3082\u306e\uff08\u3044\u308f\u3086\u308b\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\uff09\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306ePFS\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3088\u308a\u3082\u9577\u304b\u3063\u305f<\/strong><\/span>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002IDH\u5909\u7570\u304c\u3042\u308a1p\/19q\u6b20\u5931\u304c\u3042\u308b\u3082\u306e\uff08\u4e4f\u7a81\u8d77\u81a0\u816b\uff09\u3068IDH\u5909\u7570\u304c\u306a\u3044\u3082\u306e\u3067\u306f\u4e21\u7fa4\u306e\u9593\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b \u30b0\u30ec\u30fc\u30c9\uff13\u3092\u907a\u4f1d\u5b50\u8a3a\u65ad\u3067\u898b\u76f4\u3057\u3066\u307f\u305f\u3089<\/h4>\n<p>Dubbink HJ, et al.: Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial. Neuro Oncol 18:388-400, 2015<br \/>\nEORTC\u81e8\u5e8a\u7b2c\uff13\u76f8\u8a66\u9a13\u3092\u518d\u5206\u6790\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4 AO, AOA\u3068\u8a3a\u65ad\u3055\u308c\u3066\u81e8\u5e8a\u8a66\u9a13\u3055\u308c\u305f126\u4f8b\u3092\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u898b\u76f4\u3057\u305f\u3089\uff0c20\u4f8b\u304c I<span class=\"highlight\">DH<\/span>\u00a0mutation, &#8220;<span class=\"highlight\">astrocytoma<\/span>&#8220;\uff0c49\u4f8b\u304c1p\/19q codeletion, &#8220;oligodendroglioma&#8221;\uff0c55\u4f8b\u304c7+\/10q- or TERTmut and 1p\/19q intact, &#8220;glioblastoma&#8221;\u3060\u3063\u305f\u3068\u3044\u3046\u306e\u3067\u3059\u3002\u306a\u3093\u306e\u3053\u3063\u3061\u3083!! \u3053\u308c\u3067\u306f\u904e\u53bb\u306e\u30aa\u30ea\u30b4\u306e\u6cbb\u7642\u6210\u7e3e\u304c\u610f\u5473\u4e0d\u660e\u306b\u306a\u308a\u307e\u3059\u3002<br \/>\nPCV\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u304b\u5426\u304b\u306f\u3084\u306f\u308aMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u6c7a\u307e\u308b\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u3066\u3093\u304b\u3093<\/h4>\n<\/div>\n<p>Kerkhof M: Seizures in oligodendroglial tumors. CNS Oncol 2015<br \/>\n\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306e70-90%\u306b\u3066\u3093\u304b\u3093\u304c\u751f\u3058\u307e\u3059\u3002\u307e\u305f\uff0c\u3066\u3093\u304b\u3093\u767a\u75c7\u3057\u305f\u4f8b\u306f\u9577\u671f\u4e88\u5f8c\u304c\u826f\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u816b\u760d\u6458\u51fa\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u30673\u5206\u306e\uff12\u306e\u60a3\u8005\u3055\u3093\u3067\u3066\u3093\u304b\u3093\u767a\u4f5c\u304c\u6b62\u307e\u308a\uff0c\u5316\u5b66\u7642\u6cd5\u3067\u306f50%\u307b\u3069\u3067\u3066\u3093\u304b\u3093\u767a\u4f5c\u304c\u6539\u5584\u3057\u307e\u3059\u3002\u30ec\u30d9\u30c1\u30e9\u30bb\u30bf\u30e0\u3082\u3057\u304f\u306f\u30d0\u30eb\u30d7\u30ed\u9178\u306e\u5358\u72ec\u6295\u4e0e\u304c\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u90e8\u5206\u3066\u3093\u304b\u3093\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff0c40%\u307b\u3069\u3067\u6297\u3066\u3093\u304b\u3093\u85ac\u6cbb\u7642\u4e2d\u306b\u85ac\u5264\u62b5\u6297\u6027\u306e\u3066\u3093\u304b\u3093\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u00a0IDH1\u5909\u7570\u304c\u3042\u308b\u3068\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u304c\u6709\u52b9<\/h4>\n<p>Cairncross JG, et al.: Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol 32: 783-790, 2014<br \/>\nRTOG 9402\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u30021p\/19q\u6b20\u5931\u304c\u7121\u304f\u3066\u3082\u9577\u671f\u751f\u5b58\u3059\u308b\u4f8b\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u9577\u671f\u751f\u5b58\u4f8b\u3067IDH1\u5909\u7570\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u3068\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u3092\u7528\u3044\u305f\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3048\u3070\uff0c1p\/19q\u6b20\u5931\u3068IDH1\u5909\u7570\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4\u306e\u5168\u751f\u5b58\u671f\u9593\u306f14.7\u5e74\u306b\u53ca\u3093\u3060\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<h4><span style=\"background-color: #f4f9ff;\">\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u3068\u4e88\u5f8c<\/span><\/h4>\n<p>Minniti G, et al.: Chemoradiation for anaplastic oligodendrogliomas: clinical outcomes and prognostic value of molecular markers. J Neurooncol 116: 275-282, 2014<br \/>\n\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4 (AO, AOA)\u306e\u5831\u544a\u3067\u3059\u300284\u4eba\u306e\u60a3\u8005\u304c\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u3067\u6cbb\u7642\u3055\u308c\uff0c\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f56\u30f6\u6708\uff0c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f45\u304b\u6708\u3067\u3057\u305f\u3002<span style=\"color: #ff0000;\"><strong>Chromosome 1p\/19q codeletion 57 %, IDH1 mutation 63 %, MGMT promoter methylation 74 %<\/strong><\/span>\u3067\u3042\u3063\u305f\u305d\u3046\u3067\u3059\u3002\u7b2c1\/\u7b2c19\u67d3\u8272\u4f53\u6b20\u5931\u304c\u7121\u304b\u3063\u305f\u4f8b\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f34\u30f6\u6708\uff0c\u6b20\u5931\u304c\u3042\u3063\u305f\u4f8b\u3067\u306f\u8ffd\u8de1\u6a5f\u9593\u3088\u308a\u9577\u304f\u9577\u671f\u306b\u306a\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002IDH1\u5909\u7570\u4f8b\u3067\u3082\u751f\u5b58\u671f\u9593\u306f\u9577\u304b\u3063\u305f\u306e\u3067\u3059\u304c\uff0cMGMT\u306e\u30c7\u30fc\u30bf\u306f\u4e88\u5f8c\u3068\u660e\u3089\u304b\u306a\u95a2\u4fc2\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a1p\/19q codeletion \u67d3\u8272\u4f53\u7570\u5e38\u304c\u3042\u308b\u3068\u6cbb\u7652\u3082\u671f\u5f85\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u30c7\u30fc\u30bf\u3067\u3059\u3002<\/p>\n<h4>\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u3068\u4e88\u5f8c<\/h4>\n<\/div>\n<p>Gorlia T, Delattre JY, Brandes AA, et al. New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951. Eur J Cancer 2013<br \/>\nEORTC\u306b\u767b\u9332\u3055\u308c\u3066\u305f368\u4f8b\u306e\u30b0\u30ec\u30fc\u30c9\uff13\u30aa\u30ea\u30b4 OA, AOA\u306e\u89e3\u6790\u3067\u3059\u3002\u4e88\u5f8c\u304c\u826f\u3044\u60a3\u8005\u3055\u3093\u3068\u306f\uff0c\u82e5\u3044\uff0c\u624b\u8853\u3067\u5168\u6458\u51fa\u3055\u308c\u3066\u3044\u308b\uff0c\u524d\u982d\u8449\u767a\u751f\uff0cPS \u4e00\u822c\u72b6\u614b\u304c\u826f\u3044\uff0c\u58ca\u6b7b\u3084\u8840\u7ba1\u5185\u76ae\u80a5\u539a\u304c\u306a\u3044\uff0c1p\/19q\u6b20\u5931\uff0cIDH\u5909\u7570\u3067\u3057\u305f\u3002\u5f8c\u306b\uff0c<span style=\"color: #000080;\"><strong>\u624b\u8853\u6458\u51fa\u5272\u5408\u304c\u9ad8\u3044\u3068\u751f\u547d\u4e88\u5f8c\u304c\u826f\u3044<\/strong><\/span>\u3068\u3044\u3046\u6839\u62e0\u306b\u3088\u304f\u5f15\u7528\u3055\u308c\u308b\u8ad6\u6587\u3067\u3059\u3002<\/p>\n<div class=\"setumei\">\n<h4>\u00a0\u653e\u5c04\u7dda\u6cbb\u7642\u306bPCV\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u305f\u65b9\u304c\u6cbb\u308b\u78ba\u7387\u304c\u9ad8\u3044<\/h4>\n<p>van den Bent MJ, et al.: Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. J Clin Oncol 31:344-350, 2013<br \/>\n\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4 (AO, AOA) \u306b\u5bfe\u3057\u3066\uff0c59.4\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306bPCV\u5316\u5b66\u7642\u6cd56\u30b3\u30fc\u30b9\u306e\u4e0a\u4e57\u305b\u52b9\u679c\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u307f\u305f\u81e8\u5e8a\u7b2c3\u76f8\u8a66\u9a13\u3067\u3059\u3002368\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3055\u308c\uff0c\u8ffd\u8de1\u6a5f\u9593\u4e2d\u592e\u5024\u306f140\u30f6\u6708\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c\u653e\u5c04\u7dda\u5358\u72ec\u3067\u306f30.6\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u3068PCV\u3067\u306f42.3\u30f6\u6708\u3067\u6709\u610f\u306a\u5dee\u304c\u3042\u308a\u307e\u3057\u305f\u3002<span style=\"color: #000000;\">1p\/19q coleletion\u304c\u3042\u3063\u305f\u60a3\u8005\u3055\u309380\u4eba\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f\uff0c<span style=\"color: #ff0000;\"><strong>\u653e\u5c04\u7dda\u5358\u72ec\u3067\u306f112\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u3068PCV\u3067\u306f7\u5e74\u4ee5\u4e0a<\/strong><\/span><\/span><span style=\"color: #ff0000;\"><strong>\u3067\u6709\u610f\u306a\u5dee<\/strong><\/span>\u304c\u3042\u308a\u307e\u3057\u305f\u3002IDH1\u5909\u7570\u304c\u3042\u3063\u305f\u4f8b\u3067\u3082\u751f\u5b58\u671f\u9593\u304c\u9577\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4\u306b\u306f\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u305f\u65b9\u304c\u826f\u3044\u3053\u3068\u304c\u660e\u767d\u3068\u306a\u308a\u307e\u3057\u305f\u3002<span style=\"color: #ff0000;\"><strong>1p\/19q\u6b20\u5931\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c93\u306e\u30aa\u30ea\u30b4\u306e\u751f\u547d\u4e88\u5f8c\u306f\u77ed\u304f\u3068\u30827\u5e74\u4ee5\u4e0a\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\uff0c\u6cbb\u7652\u304c\u671f\u5f85\u3055\u308c\u308b\u816b\u760d\u3067\u3042\u308b\u3068\u8a00\u3048\u307e\u3059<\/strong><\/span>\u3002\u4e00\u65b9\u3067\uff0c\u305d\u306e\u6b20\u5931\u304c\u7121\u3044\u4f8b\u3067\u306e\u751f\u547d\u4e88\u5f8c\u306f\u6570\u5e74\u4ee5\u5185\u3068\u63a8\u5b9a\u3055\u308c\u307e\u3059\u3002\u3068\u3066\u3082\u5927\u304d\u306a\u9055\u3044\u3067\u3059\u3002<\/p>\n<h4>1p\/19q\u6b20\u5931\u304c\u3042\u308b\u4f8b\u306b\u306fPCV\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9<\/h4>\n<p>Cairncross G, et al.: Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol 31: 337-343, 2013<br \/>\n\u30b0\u30ec\u30fc\u30c93\u30aa\u30ea\u30b4 (AO, AOA)291\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u3042\u308b\u3044\u306fPCV\u5316\u5b66\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u3067\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f4.6\u5e74\u30684.7\u5e74\u3067\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\uff0c1p\/19q loss\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u653e\u5c04\u7dda\u5358\u72ec\u30677.3\u5e74\uff0cPCV\u653e\u5c04\u7dda\u306714.7\u5e74\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u4e0a\u8a18\u306eRTOG\u306e\u5831\u544a\u3068\u306f\u304b\u306a\u308a\u306e\u77db\u76fe\u304c\u3042\u308a\u307e\u3059\u3002<strong><span style=\"color: #ff0000;\">1p\/19q\u6b20\u5931\u304c\u306a\u3044\u3068\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3063\u3066\u3082\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f2\u5e74\u534a\u307b\u3069\u3067\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u3055\u3093\u304c\u4ea1\u304f\u306a\u308a\u307e\u3059\u3002\u9006\u306b\u6b20\u5931 codeletion\u304c\u3042\u308c\u3070\uff0c\u6cbb\u7652\u304c\u671f\u5f85\u3067\u304d\u308b\u307b\u3069\u306e\u9577\u671f\u751f\u5b58\u4f8b\u304c\u591a\u3044\u3068\u8a00\u3048\u307e\u3059<\/span><\/strong>\u3002\u3082\u306e\u3059\u3054\u304f\u5927\u304d\u306a\u5dee\u3067\u3059\u3002<\/p>\n<div>\n<h4><strong><span style=\"color: #000080;\">\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u6cbb\u7642\u306e\u6700\u8fd1\u306e\u30c8\u30ec\u30f3\u30c9<\/span><\/strong><\/h4>\n<p align=\"left\">Panageas KS, et al.: Initial treatment patterns over time for anaplastic oligodendroglial tumors. Neuro Oncol 14:761-767, 2012<br \/>\n\u7c73\u56fd\u306e\u8133\u816b\u760d\u306e\u5c02\u9580\u5bb6\u306e\u9593\u3067\u306e2012\u5e74\u306b\u304a\u3051\u308b\u30c8\u30ec\u30f3\u30c9\u8abf\u67fb\u3067\u3059\u3002<span style=\"color: #ff0000;\"><strong>\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u6cbb\u7642\u3067\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c987%\u306b\u5bfe\u3057\u3066\uff0cPCV\u304c2%\u3068\u5b8c\u5168\u306b\u3072\u3063\u304f\u308a\u8fd4\u308a\u307e\u3057\u305f\u3002<\/strong><span style=\"color: #000000;\">1p\/19q\u6b20\u5931\u304c\u3042\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3057\u306a\u3044\u3067\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u6cbb\u7642\u3092\u3059\u308b\u3053\u3068\u304c\u591a\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u30021p\/19q\u6b20\u5931\u304c\u306a\u3044\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u6cbb\u7642\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<\/span><\/span>\u89e3\u8aac\uff1a\u3042\u308b\u6cbb\u7642\u65b9\u6cd5\u304c\u8a08\u753b\u3055\u308c\u3066\uff0c\u81e8\u5e8a\u7814\u7a76\u3092\u7d42\u3048\u3066\u7d50\u679c\u304c\u8ad6\u6587\u306b\u306a\u308b\u306b\u306f\uff0c\u30b0\u30ec\u30fc\u30c93\u306e\u30aa\u30ea\u30b4\u306710\u5e74\uff0c\u30b0\u30ec\u30fc\u30c92\u306e\u30aa\u30ea\u30b4\u306720\u5e74\u304b\u304b\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u304c\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3057\u3066\u73cd\u91cd\u3057\u3066\u3044\u308b\u4e8b\u5b9f\u306f\uff0c\u5341\u6570\u5e74\u524d\u306b\u8a08\u753b\u3055\u308c\u305f\u201d\u6700\u65b0\u6cbb\u7642\u201d\u306a\u306e\u3067\u3059\u3002\u30c8\u30ec\u30f3\u30c9\u306e\u6cbb\u7642\u306f\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u591a\u304f\u306e\u8133\u816b\u760d\u306e\u5c02\u9580\u5bb6\u304c\u4eca\u73fe\u5728\u884c\u3063\u3066\u3044\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002<\/p>\n<h4>PCV\u5316\u5b66\u7642\u6cd5\u306f\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ec\u30fc\u30c92\u306b\u3082\u6709\u52b9\u304b<\/h4>\n<p align=\"left\">Shaw EG, et al.: Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. J Clin Oncol 30: 3065-3070, 2012<br \/>\n251\u4eba\u306e\u30b0\u30ec\u30fc\u30c9\uff12\u30b0\u30ea\u30aa\u30fc\u30de\u306e\u60a3\u8005\u3055\u3093\u3067PCV\u304c\u6709\u52b9\u304b\u3069\u3046\u304b\u3092\u307f\u305f\u7814\u7a76\u3067\u3059\u3002PCV\u304c\u6709\u52b9\u3068\u306e\u7d50\u8ad6\u3067\u3059\u304c\uff0c\u3053\u306e\u7814\u7a76\u306f\u3073\u307e\u3093\u6027\u661f\u7d30\u80de\u816b\u304c\u6df7\u3058\u3063\u3066\u3044\u308b\u306e\u3067\u7d50\u8ad6\u306e\u6570\u5b57\u306f\u5f79\u306b\u7acb\u3061\u307e\u305b\u3093\u3002\u30b0\u30ec\u30fc\u30c9\uff12\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306bPCV\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\">IGS-9 subtype\u306e\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760d\u306b\u306fPCV\u5316\u5b66\u7642\u6cd5\u306e\u6709\u52b9\u6027\u304c\u9ad8\u3044<\/span><\/h4>\n<p align=\"left\">Erdem-Erasian L, et al.: Intrinsic Molecular Subtypes of Glioma Are Prognostic and Predict Benefit From Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Combination With Other Prognostic Factors in Anaplastic Oligodendroglial Brain Tumors. J Clin Oncol 44: 1444, 2012<br \/>\n\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4\u3092\u7814\u7a76\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u00a0IGS-9 (1p\/19q\u306e\u6b20\u5931\u7387\u304c\u975e\u5e38\u306b\u9ad8\u304fIDH1\u5909\u7570\u304c\u3042\u308b)\u3068\u3044\u3046\u30bf\u30a4\u30d7\u3067\u306f\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u3067\u306e\u5168\u751f\u5b58\u671f\u9593\u304c5.5\u5e74\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3068PCV\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u305f\u7fa4\u3067\u306e\u751f\u5b58\u671f\u9593\u304c12.8\u5e74\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a1p\/19q\u306e\u6b20\u5931\u7387\u304c\u975e\u5e38\u306b\u9ad8\u304fIDH1\u5909\u7570\u304c\u3042\u308bAO\/AOA\u3067\u306f\uff0cPCV\u5316\u5b66\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u3079\u304d\u3060\u3068\u3044\u3046\u9ad8\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u9006\u306b\uff0c\u3053\u306e\u30bf\u30a4\u30d7\u3067\u306f\u306a\u3044\u3068PCV\u5316\u5b66\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306f\u8457\u3057\u304f\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u307e\u305f\uff0c59.4\u30b0\u30ec\u30a4\u3068\u3044\u3046\u304d\u3064\u3044\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u4f75\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304b\u3089\uff0cPCV\u5358\u72ec\u3067\u306f\u3053\u306e\u6210\u7e3e\u306f\u51fa\u307e\u305b\u3093\u3002<\/p>\n<h4><span style=\"color: #000080;\">\u30b0\u30ec\u30fc\u30c9\uff13\u30aa\u30ea\u30b4\u306e\u751f\u5b58\u671f\u9593\u306fPCV\u5316\u5b66\u7642\u6cd5\u3067\u5ef6\u9577\u3067\u304d\u308b<\/span><\/h4>\n<p align=\"left\">van den Bent MJ, et al: Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951. J Clin Oncol. 2012 Oct<br \/>\n368\u4eba\u306e\u30b0\u30ec\u30fc\u30c9\uff13\u30aa\u30ea\u30b4(AO\u3068AOA)\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3055\u308c\uff0c\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u5024\u306f140\u30f6\u6708\u3067\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3068PCV\u5316\u5b66\u7642\u6cd5\u3067\u6cbb\u7642\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024 OS\u306f42.3\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u5358\u72ec\u3067\u306f30.6\u30f6\u6708\u3067\u3057\u305f\u30021p\/19q\u6b20\u5931\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u3060\u3051\u3092\u62bd\u51fa\u3059\u308b\u3068PCV\u5316\u5b66\u7642\u6cd5\u7fa4\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f10\u5e74\u3092\u8d85\u3048\u308b\u3067\u3057\u3087\u3046\u3002IDH\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\u3082\u3053\u306e\u6cbb\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306f\u9ad8\u3044\u305d\u3046\u3067\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u4e0b\u306e\u65b9\u306b\u66f8\u3044\u3066\u3042\u308b2006\u5e74\u306e\u8ad6\u6587\u306e\u7d50\u8ad6\u3092\u8986\u3059\u30e8\u30fc\u30ed\u30c3\u30d1(EORTC)\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002PCV\u5316\u5b66\u7642\u6cd5\u3092\u884c\u3046\u6839\u62e0\u304c\u62c5\u4fdd\u3055\u308c\u307e\u3057\u305f\u3002PCV 6\u30b3\u30fc\u30b9\u3068\u5c40\u6240\u5206\u5272\u7167\u5c04 59.4\u30b0\u30ec\u30a4\uff081.8\u30b0\u30ec\u30a4\/\u65e5\uff09\u3092\u4f7f\u7528\u3059\u308b\u306e\u3067\u3059\u304c\uff0c\u3053\u308c\u306f\u304b\u306a\u308a\u304d\u3064\u3044\u6cbb\u7642\u3067\uff0c\u653e\u5c04\u7dda\u969c\u5bb3\u306b\u3088\u308b\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u304c\u3067\u308b\u4f8b\u304c\u304b\u306a\u308a\u3042\u308a\u307e\u3059\u3002\u751f\u304d\u6b8b\u3063\u305f\u3068\u304d\u306e\u751f\u5b58\u306e\u8ceaADL\u3092\u8003\u3048\u308c\u3070\uff0c\u306a\u304b\u306a\u304b\u9078\u629e\u3057\u3065\u3089\u3044\u6cbb\u7642\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n<\/div>\n<h4><span style=\"color: #000080;\"><span class=\"style1\">1p\/19q\u6b20\u5931\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c9\uff13\u30aa\u30ea\u30b4\u306e\u521d\u671f\u6cbb\u7642\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3060\u3051\u4f7f\u3046<\/span><\/span><\/h4>\n<p>Mikkelsen T, et. al.: Temozolomide single-agent chemotherapy for newly diagnosed anaplastic oligodendroglioma. J Neurooncol 92: 57-63, 2009<br \/>\n\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816bAO\u306e\u521d\u671f\u6cbb\u7642\u3067\uff0c1p\/19q\u6b20\u5931\u304c\u3042\u308b\u816b\u760d\u306e36\u4eba\u306e\u60a3\u8005\u3055\u3093\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u6bb5\u72ec\u6cbb\u7642\uff0c1p\/19q\u6b20\u5931\u306e\u306a\u304412\u4eba\u306e\u60a3\u8005\u3055\u3093\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u30021p\/19q\u6b20\u5931\u306e\u3042\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\u306ePFS\u7121\u5897\u60aa\u671f\u9593\u4e2d\u592e\u5024\u306f29\u30f6\u6708\uff0c1p\/19q\u6b20\u5931\u304c\u306a\u304f\u653e\u5c04\u7dda\u6cbb\u7642\u3082\u53d7\u3051\u305f\u60a3\u8005\u3055\u3093\u306ePFS\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f14\u30f6\u6708\u3067\u3057\u305f\u30021p\/19q\u6b20\u5931\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u521d\u671f\u6cbb\u7642\u304c\u53ef\u80fd\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a<strong><span style=\"color: #ff0000;\">\u3053\u306e\u8ad6\u6587\u306e\u7d50\u679c\u89e3\u91c8\u306f\u4e71\u66b4\u3067\u3059<\/span><\/strong>\u30021p\/19q codeletion\u304c\u3042\u308bAO\u306e\u60a3\u8005\u3055\u3093\u306e\u9577\u671f\u751f\u547d\u4e88\u5f8c\u306f\u3082\u3068\u3082\u3068\u826f\u3044\u3067\u3059\u3002\u3067\u3059\u304c\uff0c10\u5e74\u5358\u4f4d\u3067\u307f\u308c\u3070\u7d50\u679c\u7684\u306b\u306f\uff0c\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u304c\u518d\u71c3\u6b7b\u4ea1\u3057\u307e\u3059\u3002\u6cbb\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u521d\u671f\u6cbb\u7642\u3067\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u7701\u304f\u3068\u3044\u3046\u306e\u306f\u73fe\u6642\u70b9\u3067\u306f\u884c\u304d\u904e\u304e\u3067\u3059\u3002\u6cbb\u7652\uff08\u771f\u306e\u9577\u671f\u751f\u5b58\uff09\u3092\u6c42\u3081\u308b\u306a\u3089\u521d\u671f\u6cbb\u7642\u306f\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u3060\u3051\u306e\u6cbb\u7642\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4>\u30b0\u30ec\u30fc\u30c93\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306fIDH\u5909\u7570\u306e\u6709\u7121\u304c\u4e88\u5f8c\u306b\u6700\u3082\u95a2\u9023\u3059\u308b<\/h4>\n<p>Wick W, et al. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 2009<br \/>\n2009\u5e74\u306e\u4e2d\u9593\u89e3\u6790\u3067\uff0c2016\u5e74\u306b\u6700\u7d42\u5831\u544a\u304c\u51fa\u3066\u3044\u307e\u3059\u30021p\/19q\u6b20\u640d\uff0cMGMT\u30e1\u30c1\u30ec\u30fc\u30b7\u30e7\u30f3\u3088\u308a\u3082\uff0cIDH\u306e\u5909\u7570\u306e\u6709\u7121\u306e\u65b9\u304c\u6cbb\u7642\u52b9\u679c\u306b\u5927\u304d\u306a\u5f71\u97ff\u304c\u3042\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u30022018\u5e74\u6642\u70b9\u3067\u306f\uff0c\u305d\u3082\u305d\u3082IDH\u306e\u5909\u7570\u304c\u306a\u3044\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b AO \u3068\u3044\u308f\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002AO\u3067\u306f\u624b\u8853\u5f8c\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\u304c\u540c\u7b49\u306e\u52b9\u679c\u3092\u793a\u3059\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u304c\uff0c2018\u5e74\u6642\u70b9\u3067\u306f\u5426\u5b9a\u7684\u3067\u3059\u3002<\/p>\n<h4><span class=\"style1\" style=\"color: #000080;\">\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u5927\u91cf\u5316\u5b66\u7642\u6cd5\u3092\u884c\u306a\u3046<\/span><\/h4>\n<p>Mohile NA , et. al.: A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis. J Neurooncol 89: 187-193, 2008<br \/>\n\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816bAO\u306e\u521d\u671f\u6cbb\u7642\u3067\uff0c\u7528\u91cf\u306e\u591a\u3044\u30d7\u30ed\u30ab\u30eb\u30d0\u30b8\u30f3\uff0c\u30ed\u30e0\u30b9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3(I-PCV)\u5316\u5b66\u7642\u6cd5\u304c\u884c\u306a\u308f\u308c\u3066\uff0c\u53cd\u5fdc\u306e\u3042\u3063\u305f\u60a3\u8005\u3055\u3093\u306b\u306f\u3055\u3089\u306bAPBPCR\u306b\u3088\u308b\u5927\u91cf\u5316\u5b66\u7642\u6cd5\uff08\u30d6\u30b5\u30eb\u30d5\u30a1\u30f3\uff0c\u30c1\u30aa\u30c6\u30fc\u30d1\uff09\u304c\u52a0\u3048\u3089\u308c\u307e\u3057\u305f\u300215\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u5316\u5b66\u7642\u6cd5\u53cd\u5fdc\u6027\u304c\u3042\u308a\uff0c14\u4eba\u304cAPBPCR\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u3067\u306f\uff0c\u809d\u81d3\u306eVOD\u3067\uff11\u4eba\u304c\u4ea1\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306f36\u30f6\u6708\u4ee5\u4e0a\u3067\u3057\u305f\u3002<br \/>\n\u89e3\u8aac\uff1a\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u4e2d\u65ad\u3055\u308c\u307e\u3057\u305f\u3002\u5148\u884c\u6cbb\u7642\u3068\u524d\u6cbb\u7642\u306e\u526f\u4f5c\u7528\u304c\u5f37\u3059\u304e\u308b\u305f\u3081\u3067\u3057\u305f\u3002\u73fe\u5728\u306fI-PCV\u3092\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306b\u5909\u66f4\u3057\u3066\u540c\u3058\u8a66\u9a13\u304c\u7d99\u7d9a\u3055\u308c\u3066\u3044\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u3044\u304d\u306a\u308a\u5168\u304f\u306a\u304f\u3059\u3068\u3044\u3046\u306e\u306f\u3061\u3087\u3063\u3068\u5192\u967a\u904e\u304e\u307e\u3059\u3002<\/p>\n<h4><span class=\"style1\" style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u524d\u306b\u4f7f\u7528\u3059\u308b<\/span><\/h4>\n<p>Vogelbaum, et. al.: Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. Neuro Oncol 2008<br \/>\n150mg\/m2\/day\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\uff17\u65e5\u9593\u9023\u7d9a\u3067\u670d\u7528\u3057\u3066\uff17\u65e5\u9593\u4f11\u3080\u3068\u3044\u3046\u5316\u5b66\u7642\u6cd5 (dose dense therapy) \u3092\uff16\u30b3\u30fc\u30b9\u307e\u3067\u7d9a\u3051\u307e\u3059\u3002\u305d\u308c\u304b\u3089\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6cbb\u7642\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u30b0\u30ec\u30fc\u30c9\uff13\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760dAO\/AOA\u306e39\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u6700\u521d\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u594f\u529f\u7387\u306f32%\u3067\uff0c\u816b\u760d\u304c\u6d88\u5931\u3057\u305f(CR?)\u306e\u306f6%\u3067\uff0c\u304b\u306a\u308a\u5c0f\u3055\u304f\u306a\u3063\u305f(PR)\u306e\u304c26%\u3067\uff0c\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3057\u307e\u3063\u305f(PD)\u306e\u304c10%\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u306f\u3063\u304d\u308a\u3057\u305f\u7d50\u679c\u306f\u3042\u308a\u307e\u305b\u3093\u30021p\/19q loss\u306e\u3042\u3063\u305f\u60a3\u8005\u3055\u3093\u3067\u306f\u653e\u5c04\u7dda\u524d\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u671f\u9593\u306b\uff11\u4f8b\u3082\u5897\u60aa\u4f8b\u304c\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a\u3044\u3064\u3082\u306e\u3053\u3068\u3067\u3059\u304c\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306eCR\u306e\u5b9a\u7fa9\u304c\u554f\u984c\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u306e\u8457\u8005\u306fT2\/FLAIR\u3067\u306e\u5b8c\u5168\u306a\u816b\u760d\u6d88\u5931\u3092CR\u3068\u53b3\u3057\u304f\u5b9a\u7fa9\u3057\u305f\u306e\u3067CR\u304c2\u4f8b(6%)\u3057\u304b\u306a\u304b\u3063\u305f\u3068\u66f8\u3044\u3066\u3044\u307e\u3059\u304c\uff0c\u307b\u3093\u3068\u3046\u306b\u305d\u3093\u306a\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u90e8\u5206\u6458\u51fa\u3057\u305f\u30b0\u30ea\u30aa\u30fc\u30de\u304cT2\/FLAIR\u753b\u50cf\u3067\u5b8c\u5168\u6d88\u5931\u3059\u308b\u3053\u3068\u306f\u307e\u305a\u3042\u308a\u5f97\u307e\u305b\u3093\u3057\uff0c\u4f55\u3089\u304b\u306e\u75d5\u8de1\u306f\u6b8b\u308b\u306f\u305a\u306a\u306e\u3067\u3059\u3002<span style=\"color: #000080;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u524d\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5f37\u5316\u7642\u6cd5\u306e\u610f\u7fa9\u306f\uff0c\u653e\u5c04\u7dda\u7167\u5c04\u91ce\u3092\u8d8a\u3048\u3066\u6d78\u6f64\u3059\u308b\u816b\u760d\u7d30\u80de\u306b\u5bfe\u3057\u3066\u306e\u5f37\u304f\u3066\u65e9\u3044\u6642\u671f\u306e\u5316\u5b66\u7642\u6cd5\u3092\u53ef\u80fd\u306b\u3059\u308b\u3053\u3068\u3067\u3042\u308b<\/strong><\/span>\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff0c\u672c\u5f53\u306b\u305d\u3046\u3067\u3057\u3087\u3046\u304b\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u4e2d\u3068\u6cbb\u7642\u5f8c\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u3067\u306f\u3044\u3051\u306a\u3044\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306f\uff11\u65e51.8Gy\u306759.4Gy\u307e\u3067\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u306e\u53b3\u3057\u3044\u7167\u5c04\u7dda\u91cf\u3092\u6e1b\u3058\u308b\u3053\u3068\u306f\u53ef\u80fd\u304b\u3069\u3046\u304b\u77e5\u308a\u305f\u3044\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\"><span class=\"style1\">\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306b\u5bfe\u3057\u3066\u7c73\u56fd\u306e\u5c02\u9580\u5bb6\u306e\u63a8\u5968\u3059\u308b\u6cbb\u7642\u6cd5<\/span><\/span><\/h4>\n<p>Abrey LE , et. al.: Survey of treatment recommendations for anaplastic oligodendroglioma. Neuro Oncol 9: 314-318, 2007<br \/>\n2006\u5e74\u306b\u7c73\u56fd\u306e\u795e\u7d4c\u816b\u760d\u533b\u306b\u30a2\u30f3\u30b1\u30fc\u30c8\u8abf\u67fb\u3092\u884c\u3063\u305f\u7d50\u679c\u3067\u3059\u3002\u67d3\u8272\u4f53\u691c\u67fb\u306e\u7d50\u679c\u304c\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u306b\u6975\u3081\u3066\u5f37\u3044\u7d50\u679c\u3092\u4e0e\u3048\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3057\u305f\u30021p\/19q\u6b20\u5931\u306e\u6709\u308b\u7121\u3057\u3067\u63a8\u5968\u3059\u308b\u6cbb\u7642\u304c\u5909\u308f\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u8208\u5473\u3042\u308b\u3053\u3068\u306b\uff0c\u7c73\u56fd\u3067\u306f\u3053\u306e\u691c\u67fb\u6599\u91d1\u306f\u60a3\u8005\u3055\u3093\u306b\u8acb\u6c42\u3055\u308c\u308b\u306e\u3067\u3059\u304c\u533b\u5e2b\u304c\u305d\u306e\u6599\u91d1\u3092\u77e5\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6700\u3082\u591a\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u305f\u6cbb\u7642\u6cd5\u306f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u4f75\u7528 concurrent\u3068\uff0c\u305d\u306e\u5f8c\u306e\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u7dad\u6301\u7642\u6cd5\u3067\u3057\u305f\u30021p\/19q\u6b20\u5931\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u3078\u306f42%\u306e\u533b\u5e2b\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u305b\u305a\u306b\u5316\u5b66\u7642\u6cd5\uff08\u5927\u90e8\u5206\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\uff09\u3092\u52e7\u3081\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<h4><span style=\"color: #000080;\">1p\/19q\u6b20\u5931\u304c\u3042\u308b\u30b0\u30ec\u30fc\u30c9\uff13\u30aa\u30ea\u30b4\u306b\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u52b9\u6027\u304c\u9ad8\u3044<\/span><\/h4>\n<p>Brandes AA, et. al.: Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study. J Clin Oncol 24: 4746-3138, 2006<br \/>\n\u6a19\u6e96\u7684\u306a\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f8c\u3067\u518d\u767a\u3057\u305f\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816bAO\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816bAOA\u306e67\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u306b\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002\u594f\u529f\u5272\u5408\u306f46% (17 CR, 14 PR)\u3068\u975e\u5e38\u306b\u9ad8\u3044\u3082\u306e\u3067\u3057\u305f\u3002AO\u3067\u306f62%\uff0cAOA\u3067\u306f25%\u3067\u3057\u305f\u304b\u3089\uff0c\u661f\u7d30\u80de\u816b\u306e\u6210\u5206\u3092\u542b\u307e\u306a\u3044\u7d44\u7e54\u306e\u65b9\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u52b9\u6027\u306f\u660e\u3089\u304b\u306b\u9ad8\u3044 (p=0.003) \u7d50\u679c\u3067\u3057\u305f\u3002\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f31\u30f6\u6708\uff0c\u6cbb\u7642\u5f8c\uff13\u5e74\u3067\u306e\u751f\u5b58\u5272\u5408\u306f43%\u3067\u3059\u3002\u7d44\u7e54\u691c\u67fb\u3067\u7b2c\uff11\u67d3\u8272\u4f53\u5358\u8155 1p\u3068\u7b2c19\u67d3\u8272\u4f53\u9577\u8155 19q\u306e\u6b20\u5931\u304c\u3042\u3063\u305f\u816b\u760d\u306e\u594f\u52b9\u5272\u5408\uff0c\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff0c\u5168\u751f\u5b58\u671f\u9593\u306f\uff0c\u305d\u3046\u3067\u306a\u3044\u816b\u760d\u3088\u308a\u3082\u660e\u3089\u304b\u306b\u826f\u597d\u306a\u7d50\u679c\u3060\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\uff0cMGMT\u30e1\u30c1\u30eb\u5316\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u6709\u52b9\u6027\u306e\u95a2\u9023\u306f\u306f\u3063\u304d\u308a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u30021p\/19q allelic loss\u306fpredictive and prognostic factor\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a<span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u5264\u3067\u4f7f\u7528\u3057\u3066\u3082\uff0c\u518d\u767a\u3057\u305f\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u7cfb\u816b\u760d\u306b\u304b\u306a\u308a\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u3067\u3059<\/strong><\/span>\u3002\u7279\u306b\uff0c1p\/19q allelic loss\u304c\u3042\u308bAO\u306b\u306f\u5927\u304d\u306a\u671f\u5f85\u3092\u3082\u3066\u307e\u3059\u3002\u3057\u304b\u3057\u9006\u306b\uff0c1p\/19q loss\u304c\u306a\u3044AOA\u306e\u60a3\u8005\u3055\u3093\u306f\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u5358\u72ec\u6295\u4e0e\u3067\u306f\u53b3\u3057\u3044\u7d50\u679c\u306b\u7d42\u308f\u3063\u3066\u3044\u307e\u3059\u3002 \u751f\u5b58\u671f\u9593\u304c\u4f38\u3073\u308b\u3068\u3044\u3063\u3066\u3082\u5927\u90e8\u5206\u306e\u60a3\u8005\u3055\u3093\u306f\u6b7b\u4ea1\u3057\u307e\u3059\u304b\u3089\uff0c\u518d\u767a\u3092\u3055\u305b\u306a\u3044\u3088\u3046\u306a\u521d\u671f\u6cbb\u7642\u304c\u91cd\u8981\u3060\u3068\u3044\u3046\u3053\u3068\u306b\u306f\u5909\u308f\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<h4><span style=\"color: #000080;\">\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u304c\u30b0\u30ec\u30fc\u30c9\uff12\u306e\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306e\u521d\u671f\u6cbb\u7642\u306b\u52b9\u679c\u304c\u3042\u308b<\/span><\/h4>\n<p>Hoang-Xuan K, et al.: Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22: 3133-3138, 2006<br \/>\n\u30d5\u30e9\u30f3\u30b9\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002\u624b\u8853\u3067\u75c5\u7406\u304c\u78ba\u304b\u3081\u3089\u308c\u305f66\u4f8b\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\uff0c\u521d\u671f\u6cbb\u7642\u3068\u3057\u3066\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u305b\u305a\u306b\u30c6\u30e2\u30c0\u30fc\u30eb\u304c\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002200mg\/m2\u3092\uff15\u65e5\u9593\u4f7f\u3046\u65b9\u6cd5\u3067\u3059\u3002\u304a\u3088\u305d11\u30b3\u30fc\u30b9\u306e\u5316\u5b66\u7642\u6cd5\u304c\u3055\u308c\u3066\u3044\u308b\u306e\u3067\uff11\u5e74\u304f\u3089\u3044\u306e\u6295\u4e0e\u671f\u9593\u3067\u3059\u300251\uff05\u306e\u60a3\u8005\u3055\u3093\u3067\u3051\u3044\u308c\u3093\u767a\u4f5c\u306a\u3069\u306e\u75c7\u72b6\u304c\u6539\u5584\u3057\u305f\u305d\u3046\u3067\u3059\u3002\u90e8\u5206\u7684\u306b\u816b\u760d\u304c\u7e2e\u5c0f\u3057\u305f\u306e\u306f31\uff05\u306e\u60a3\u8005\u3055\u3093 (PR 17%, MR 14%) \u3067\uff0c61\uff05\u3067\u306f\u5927\u304d\u3055\u304c\u5909\u308f\u3089\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\uff0c\u816b\u760d\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3057\u307e\u3063\u305f\u306e\u306f8% \u306e\u307f\u3067\u3057\u305f\u3002 \u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u308b\u306e\u306b12\u30f6\u6708\u304f\u3089\u3044\u304b\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u7b2c\uff11\u67d3\u8272\u4f53\u5358\u8155\u306b\u6b20\u5931\u306e\u3042\u308b\u816b\u760d\u306e\u65b9\u304c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306b\u3088\u304f\u53cd\u5fdc\u3057\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1a<span style=\"color: #000080;\"><strong>\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u78ba\u304b\u306b\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u5f62\u306e\u816b\u760d\u306b\u6709\u52b9\u3067\u816b\u760d\u306f\u5c0f\u3055\u304f\u306a\u308b\u306e\u3067\u3059\u304c\uff0c\u305d\u308c\u3067\u751f\u5b58\u671f\u9593\u304c\u5ef6\u9577\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u307e\u3060\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u305b\u3093<\/strong><\/span>\u3002\u73fe\u5728\u9032\u884c\u4e2d\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306b\u5bfe\u3057\u3066\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u307f\uff0c\u653e\u5c04\u7dda\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u3092\u8ef8\u3068\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u306e\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u308b\u306b\u306f\u307e\u3060\u6642\u9593\u304c\u304b\u304b\u308a\u307e\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\">PCV\u5316\u5b66\u7642\u6cd5\u306f\u518d\u71c3\u307e\u3067\u306e\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\u304c\u9577\u671f\u751f\u5b58\u7387\u3092\u6539\u5584\u3057\u306a\u3044<\/span><\/h4>\n<p>Cairncross G, et al.: Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. J Clin Oncol 24: 2689-2690, 2006<br \/>\nRTOG\u3068\u3044\u3046\u30b0\u30eb\u30fc\u30d7\u304c\u884c\u3063\u305f\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u306e\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u306e289\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u534a\u5206\u306e\u60a3\u8005\u3055\u3093\u306f\u624b\u8853\u5f8c\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\uff0c\u6b8b\u308a\u306e\u534a\u5206\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f8c\u30676\u30b3\u30fc\u30b9\u306e<span style=\"color: #000080;\"><strong>PCV\uff08\u30d7\u30ed\u30ab\u30eb\u30d0\u30b8\u30f3\u3001\u30ed\u30e0\u30b9\u30c1\u30f3\uff0c\u30d3\u30f3\u30af\u30ea\u30b9\u30c1\u30f3\uff09<\/strong><\/span>\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\u306e\u60a3\u8005\u3055\u3093\u306b\u3082\u3057\u75c5\u6c17\u306e\u60aa\u5316\u304c\u3042\u3063\u305f\u5834\u5408\u306b\u306f\u5316\u5b66\u7642\u6cd5\u304c\u52a0\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u521d\u671f\u6cbb\u7642\u5f8c\u306b\u816b\u760d\u304c\u307e\u305f\u5927\u304d\u304f\u306a\u308b\u307e\u3067\u306e\u671f\u9593\u306f\uff0cPCV\u5316\u5b66\u7642\u6cd5\u3092\u3057\u305f\u7fa4\u30672.6\u5e74\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\u306e\u7fa4\u30671.7\u5e74\u3068\u306a\u308a\uff0cPCV \u5316\u5b66\u7642\u6cd5\u306e\u65b9\u304c\u826f\u304b\u3063\u305f\u306e\u3067\u3059\u3002\u3057\u304b\u3057\uff0c<span style=\"color: #000080;\"><strong>\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306fPCV\u306e\u7fa4\u304c4.9\u5e74\uff0c\u653e\u5c04\u7dda\u306e\u307f\u306e\u7fa4\u304c4.7\u5e74\u3068\u5dee\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f<\/strong><\/span>\u3002PCV\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f65%\u306e\u60a3\u8005\u3055\u3093\u3067CTC\u30b0\u30ec\u30fc\u30c9\uff13\u304b\u3089\uff14\u306e\u5316\u5b66\u7642\u6cd5\u306e\u526f\u4f5c\u7528\u304c\u751f\u3058\u307e\u3057\u305f\u3002<strong><span style=\"color: #000080;\">1p\u306819q\u306e\u6b20\u5931\u306f46%\u306e\u60a3\u8005\u3055\u3093\u3067\u307f\u3089\u308c\u3066\uff0c\u305d\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f7\u5e74\u3067\u3057\u305f\u3002\u4e00\u65b9\uff0c\u67d3\u8272\u4f53\u7570\u5e38\u304c\u306a\u304b\u3063\u305f\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u671f\u9593\u306f2.8\u5e74\u3067\u3057\u305f<\/span>\u3002<\/strong>\u3067\u30821p loss\u304c\u3042\u308b\u60a3\u8005\u3055\u3093\u304c PCV\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3082\u305d\u306e\u751f\u5b58\u671f\u9593\u304c\u4f38\u3073\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u9006\u306b\u5316\u5b66\u7642\u6cd5\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u76ee\u7acb\u3063\u305f\u3068\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u89e3\u8aac\uff1aPCV\u5316\u5b66\u7642\u6cd5\u306f\u6709\u52b9\u306a\u306e\u3067\u3057\u3087\u3046\u304c\uff0c\u521d\u671f\u6cbb\u7642\u3067\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u52a0\u3048\u3066\u884c\u3063\u3066\u3082\u751f\u5b58\u671f\u9593\u3092\u5ef6\u3070\u3059\u52b9\u679c\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002\u3067\u3059\u304b\u3089\u521d\u671f\u6cbb\u7642\u3067PCV\u5316\u5b66\u7642\u6cd5\u3092\u4f7f\u7528\u3059\u308b\u6839\u62e0\u306f\u306a\u3044\u3068\u8a00\u3048\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4><span style=\"color: #000080;\">PCV\u5316\u5b66\u7642\u6cd5\u306f\u6709\u52b9\u3067\u306f\u3042\u308b\u304c\u9577\u671f\u751f\u5b58\u7387\u3092\u6539\u5584\u3057\u306a\u3044<\/span><\/h4>\n<p>van den Bent et al.: Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogilomas and oligoastrocytomas: a randomized European Organization for Research and Treatment of Cancer phalse III trial. J Clin Oncol 24: 2715-2722, 2006<br \/>\n\u6b27\u5dde\u3067\u884c\u308f\u308c\u305f\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u3067\u3059\u3002\u30b0\u30ec\u30fc\u30c93\u306e\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u306e368\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u534a\u5206\u306e\u60a3\u8005\u3055\u3093\u306f59.4\u30b0\u30ec\u30a4\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\uff0c\u6b8b\u308a\u306e\u534a\u5206\u306f\u540c\u3058\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u5f8c\u3067<span style=\"color: #000080;\"><strong>6\u30b3\u30fc\u30b9\u306ePCV\u5316\u5b66\u7642\u6cd5<\/strong><\/span>\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u89b3\u5bdf\u671f\u9593\u4e2d\u592e\u5024\uff15\u5e74\u306e\u6642\u70b9\u3067\uff0c59%\u306e\u60a3\u8005\u3055\u3093\u304c\u6b7b\u4ea1\u3057\u3066\u3044\u307e\u3057\u305f\u3002PCV\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u305f38%\u306e\u60a3\u8005\u3055\u3093\u3067\u526f\u4f5c\u7528\u306e\u305f\u3081\u306b\u5316\u5b66\u7642\u6cd5\u304c\u4e2d\u65ad\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\u306e\u60a3\u8005\u3055\u3093\u306f\u518d\u767a\u3057\u305f\u6642\u306b\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<br \/>\n\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u3067\u306f\uff0cPCV\u3092\u3057\u305f\u7fa4\u304c40.3\u30f6\u6708\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u307f\u304c30.5\u30f6\u6708\u3067\u3059\u3002\u6cbb\u7642\u5f8c\u304b\u3089\u518d\u767a\u307e\u3067\u306e\u671f\u9593\u306fPCV\u3092\u52a0\u3048\u305f\u65b9\u304c\u9577\u304b\u3063\u305f\u306e\u3067\u3059\u304c\uff0c\uff15\u5e74\u751f\u5b58\u5272\u5408\u306b\u306f\u3063\u304d\u308a\u3057\u305f\u5dee\u304c\u306a\u304b\u3063\u305f\u3068\u7d50\u8ad6\u3055\u308c\u3066\u3044\u307e\u3059\u3002<span style=\"color: #000080;\"><strong>1p\u306819q\u306e\u6b20\u5931\u306f25%\u306e\u60a3\u8005\u3055\u3093\u306b\u307f\u3089\u308c\u3053\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3059\u308b\u816b\u760d\u306e\u60a3\u8005\u3055\u3093\u306e\u751f\u5b58\u5272\u5408\u306f\u9ad8\u3044\u306e\u3067\u3059\u304c\uff0cPCV\u5316\u5b66\u7642\u6cd5\u3092\u3057\u305f\u304b\u3057\u306a\u304b\u3063\u305f\u304b\u306e\u5dee\u306f\u306a\u304b\u3063\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002<br \/>\n<\/strong><\/span>\u89e3\u8aac\uff1aPCV\u5316\u5b66\u7642\u6cd5\u3092\u653e\u5c04\u7dda\u6cbb\u7642\u306b\u52a0\u3048\u3066\u3082\u3053\u306e\u816b\u760d\u304c\u6cbb\u308b\u78ba\u7387\u306b\u306f\u5dee\u304c\u306a\u3044\u3067\u3057\u3087\u3046\u3068\u3044\u3046\u306e\u304c\u7d50\u8ad6\u3067\u3067\u3057\u305f\u3002\u3060\u3068\u3059\u308b\u3068PCV\u5316\u5b66\u7642\u6cd5\u3092\u521d\u671f\u6cbb\u7642\u3067\uff16\u30b3\u30fc\u30b9\u3059\u308b\u3053\u3068\u306b\u306f\u3042\u307e\u308a\u610f\u5473\u304c\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u6349\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\u30b0\u30ec\u30fc\u30c92\u30aa\u30ea\u30b4\u306b\uff0c\u306a\u305c60\u30b0\u30ec\u30a4\u3092\u7528\u3044\u306a\u3044\u306e\u304b<\/h4>\n<p>Karim AB, et al.: A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844. Int J Radiat Oncol Biol Phys 36, 1996<br \/>\n\u53e4\u3044\u6587\u732e\u306a\u306e\u3067\u3059\u304c\uff0c\u30e8\u30fc\u30ed\u30c3\u30d1\u3067\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de LGG 343\u4f8b\u3067\u524d\u5411\u304d\u8a66\u9a13\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u00a045 Gy (5 weeks) \u3082\u3057\u304f\u306f59.4 Gy (6.6 weeks)\u306e\u7167\u5c04\u304c\u3055\u308c\u307e\u3057\u305f\u304c\uff0c74\u30f6\u6708\u306e\u8ffd\u8de1\u671f\u9593\u3067\uff0c\u5168\u751f\u5b58\u5272\u5408 OS \u306b\u3082\u7121\u5897\u60aa\u751f\u5b58\u5272\u5408 (PFS 47% vs. 50%) \u306b\u3082\u6709\u610f\u306a\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h4>\u30e1\u30e2\uff08\u67d3\u8272\u4f53\u7570\u5e38\u306e\u6709\u7121\u3067\u6cbb\u7642\u52b9\u679c\u304c\u5909\u308f\u308b\uff09<\/h4>\n<p>\u4e4f\u7a81\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306f\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u3067\u767a\u751f\u3057\u307e\u3059\u3002\u7b2c\uff11\u67d3\u8272\u4f53\u306e\u77ed\u8155\u3068\u7b2c19\u67d3\u8272\u4f53\u306e\u9577\u8155\u306b\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u7279\u306b\u7b2c\uff11\u67d3\u8272\u4f53\u77ed\u8155\u306e\u6b20\u5931(1p loss)\u304c\u3042\u308b\u816b\u760d\u3067\u306f\uff0c\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u6709\u52b9\u306a\u3053\u3068\u304c\u591a\u3044\u3068\u306e\u5b9a\u8aac\u304c\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u6cbb\u7642\u306e\u524d\u306b1p loss\u306819q loss\u3092\u8abf\u3079\u3088\u3046\u3068\u306e\u8a66\u307f\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3088\u3046\u3084\u304f\u4e00\u822c\u81e8\u5e8a\u7684\u306b\u8abf\u3079\u3089\u308c\u308b\u3068\u3053\u308d\u307e\u3067\u306f\u6765\u307e\u3057\u305f\u304c\uff0c\u691c\u67fb\u306b\u306f\u3061\u3087\u3063\u3068\u6642\u9593\u304c\u304b\u304b\u308a\u307e\u3059\u3002\u3053\u308c\u3067\u308f\u304b\u308b\u3053\u3068\u306f\uff0c1p\/19q loss\u304c\u3042\u308b\u816b\u760d\u306e\u60a3\u8005\u3055\u3093\u306f\u5316\u5b66\u7642\u6cd5\u3067\u53d7\u3051\u308b\u5229\u76ca\u304c\u5927\u304d\u304f\u3066\u3001\u305d\u3046\u3067\u306a\u3044\u60a3\u8005\u3055\u3093\u306e\u816b\u760d\u306b\u306f\u5316\u5b66\u7642\u6cd5\u304c\u52b9\u304d\u3065\u3089\u3044\u3068\u306a\u308a\u307e\u3059\u3002\u3067\u3082\u4f55\u308c\u306b\u3057\u3066\u3082\uff0c2015\u5e74\u6642\u70b9\u3067\uff0c\u624b\u8853\u5f8c\u306e\u6b8b\u5b58\u816b\u760d\u306b\u5bfe\u3057\u3066\u306f<span style=\"color: #000080;\"><strong>\u5927\u591a\u6570\u306e\u65bd\u8a2d\u3067\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5<\/strong><\/span>\u3092\u7528\u3044\u307e\u3059\u3002\u3067\u3059\u304b\u3089\uff0c\u3053\u308c\u304c\u308f\u304b\u3063\u305f\u304b\u3089\u3068\u3044\u3063\u3066\u3069\u306e\u3088\u3046\u306b\u4eca\u3042\u308b\u6cbb\u7642\u6cd5\u304c\u5909\u308f\u308b\u304b\u3068\u8a00\u3046\u3068\uff1f\uff1f\u73fe\u6642\u70b9\u3067\u306f\u79c1\u306b\u306f\u60f3\u50cf\u306f\u3064\u304d\u307e\u305b\u3093\u3002\u6b27\u7c73\u304b\u3089\u306e\u5831\u544a\u3067\u306f\uff0c\u4e4f\u7a81\u8d77\u81a0\u816b\u3068\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816b\u3092\u3042\u308f\u305b\u3066\u3082\uff0c\u539f\u767a\u6027\u8133\u816b\u760d\u306e\u5185\u3067\uff14\uff5e\uff15%\u7a0b\u5ea6\u306e\u6bd4\u8f03\u7684\u307e\u308c\u306a\u816b\u760d\u3068\u3055\u308c\u307e\u3059\u3002Norway\u3067\u306e25\u5e74\u9593\u306b\u308f\u305f\u308b\u8abf\u67fb(1953\u5e74\uff5e1977\u5e74)\u3067\u306f\uff0c208\u4f8b\u306e\u4e4f\u7a81\u8d77\u81a0\u816b\u304c\u767b\u9332\u3055\u308c\uff0c\u539f\u767a\u6027\u8133\u816b\u760d\u306e\u3046\u30614.2%\u3092\u5360\u3081\u305f\u3068\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u30022009\u5e74\u306eDenmark\u304b\u3089\u306e\u5831\u544a\u3067\u306f\u3001\u4eba\u53e310\u4e07\u306b\u5bfe\u3057\u30660.4\u4f8b\u307b\u3069\u306e\u767a\u751f\u7387\u3067\u3042\u308a\u3001\u7537\u5973\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\n\u4e4f\u7a81\u8d77\u81a0\u816b\u306e\u5e74\u9f62\u5206\u5e03\u306f20\uff5e50\u6b73\u4ee3\u306b\u591a\u304f\uff0c40\u6b73\u4ee3\u306b\u30d4\u30fc\u30af\u304c\u3042\u308b\u6210\u4eba\u306e\u816b\u760d\u3067\u3059\u3002\u60aa\u6027\u578b\u306f\u4e2d\u9ad8\u5e74\u5c64\u306b\u591a\u3044\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u7537\u5973\u6bd4\u306f\u307b\u307c\u540c\u6570\u3067\u3059\u3002\u767a\u751f\u90e8\u4f4d\u306f\u524d\u982d\u8449\uff0c\u5074\u982d\u8449\uff0c\u982d\u9802\u8449\uff0c\u5f8c\u982d\u8449\u3068\u5927\u8133\u534a\u7403\u306e\u8868\u5c64\u90e8\u306b\u591a\u304f\uff0c\u7279\u306b\u524d\u982d\u8449\u306b\u597d\u767a\u3057\u307e\u3059\u3002\u304d\u308f\u3081\u3066\u7a00\u306b\u306f\u9593\u8133\u3084\u8133\u5e79\u90e8\uff0c\u5c0f\u8133\u3042\u308b\u3044\u306f\u810a\u9ac4\u306b\u307f\u3089\u308c\u307e\u3059\u3002\u661f\u7d30\u80de\u816b\u7cfb\u816b\u760d\u3068\u7570\u306a\u308a\uff0c\u4e00\u5074\u5927\u8133\u534a\u7403\u306b\u3068\u3069\u307e\u308b\u3082\u306e\u304c\u591a\u3044\u3067\u3059\u3002\u4e4f\u7a81\u8d77\u81a0\u7d30\u80de\u7cfb\u816b\u760d\u306e\u9ac4\u6db2\u64ad\u7a2e\u306f\u4ed6\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u7570\u306a\u308a\u304d\u308f\u3081\u3066\u7a00\u3067\u3059\u3002Norway\u304b\u3089\u306e\u5831\u544a\u3067\u306f\uff0c208\u4f8b\u4e2d\u306e\uff12\u4f8b\u306b\u9ac4\u6db2\u64ad\u7a2e\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u306e\u3053\u3068\u3067\u3059\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u5916\u3078\u306e\u8ee2\u79fb\u306f\u4f8b\u5916\u7684\u306a\u3082\u306e\u3067\u3059\u3002<\/p>\n<\/div>\n<div class=\"setumei\">\n<h5>\u6587\u732e<\/h5>\n<ul>\n<li>Abrey LE , et. al.: Survey of treatment recommendations for anaplastic oligodendroglioma. Neuro Oncol 9: 314-318, 2007<\/li>\n<li>Brandes AA, et. al.: Correlations between O6-methylguanine DNA methyltransferase promoter methylation status, 1p and 19q deletions, and response to temozolomide in anaplastic and recurrent oligodendroglioma: a prospective GICNO study. J Clin Oncol 24: 4746-3138, 2006<\/li>\n<li>Buckner JC, et al.:\u00a0Radiation plus Procarbazine,\u00a0CCNU, and Vincristine in Low-Grade Glioma. N Engl J Med\u00a02016<\/li>\n<li>Cairncross G, et al.: Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. J Clin Oncol 24: 2689-2690, 2006<\/li>\n<li>Cairncross G, et al.: Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J Clin Oncol 31: 337-343, 2013<\/li>\n<li>Cairncross JG, et al.: Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH. J Clin Oncol 32: 783-790, 2014<\/li>\n<li>Dubbink HJ, et al.: Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial. Neuro Oncol 18:388-400, 2015<\/li>\n<li>Erdem-Erasian L, et al.: Intrinsic Molecular Subtypes of Glioma Are Prognostic and Predict Benefit From Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Combination With Other Prognostic Factors in Anaplastic Oligodendroglial Brain Tumors. J Clin Oncol 44: 1444, 2012<\/li>\n<li>Gorlia T, et al. New clinical, pathological and molecular prognostic models and calculators in patients with locally diagnosed anaplastic oligodendroglioma or oligoastrocytoma. A prognostic factor analysis of European Organisation for Research and Treatment of Cancer Brain Tumour Group Study 26951. Eur J Cancer 2013<\/li>\n<li>Hoang-Xuan K, et al.: Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22: 3133-3138, 2006<\/li>\n<li>Mikkelsen T, et. al.: Temozolomide single-agent chemotherapy for newly diagnosed anaplastic oligodendroglioma. J Neurooncol 92: 57-63, 2009<\/li>\n<li>Miller CR, et al.: A significance of necrosis in grading\u00a0of\u00a0oligodendroglial neoplasms: a clinicopathlogic and genetic study of newly diagnosed high-grade gliomas. J Clin Oncol 24: 5419-5426, 2006<\/li>\n<li>Minniti G, et al.: Chemoradiation for anaplastic oligodendrogliomas: clinical outcomes and prognostic value of molecular markers.\u3000 J Neurooncol 116: 275-282, 2014<\/li>\n<li>Mohile NA , et. al.: A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis. J Neurooncol 89: 187-193, 2008<\/li>\n<li>Nielsen MS, et al.: Incidence of and survival from oligodendroglioma in Denmark, 1943-2002. Neuro-Oncol 11: 311-317, 2009<\/li>\n<li>Shaw EG, et al.: Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. J Clin Oncol 30: 3065-3070, 2012<\/li>\n<li>van den Bent et al.: Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogilomas and oligoastrocytomas: a randomized European Organization for Research and Treatment of Cancer phalse III trial. J Clin Oncol 24: 2715-2722, 2006<\/li>\n<li>van den Bent MJ, et al: Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951. J Clin Oncol. 2012 Oct<\/li>\n<li>van den Bent MJ, et al.: Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. J Clin Oncol 31:344-350, 2014<\/li>\n<li>Vogelbaum, et. al.: Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. Neuro Oncol 2008 (Epub)<\/li>\n<li>Wick W, et al. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 2009<\/li>\n<\/ul>\n<h5>\u3067\u306f\u79c1\u306a\u3089\uff0c\u30b0\u30ec\u30fc\u30c9\uff13\u306e\u30aa\u30ea\u30b4\u306b\u3069\u3046\u3044\u3046\u6cbb\u7642\u3092\u3059\u308b\u304b<\/h5>\n<ul>\n<li>\u305d\u3082\u305d\u30821p\/19q\u6b20\u5931\u304c\u306a\u3044\u3068\u30aa\u30ea\u30b4\u3068\u8a00\u308f\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u305d\u308c\u306f\u5225\u306b\u3057\u3066\uff0c\u7d44\u7e54\u8a3a\u65ad\u3067NOS\u3092\u542b\u3081\u305f\u6cbb\u7642\u9078\u629e\u3092\u8003\u3048\u307e\u3059<\/li>\n<li>2016\u5e74\u307e\u3067\u306e\u60c5\u5831\u3092\u3075\u307e\u3048\u3066\u3082\uff0c1p\/19q\u6b20\u5931\u3084IDH\u5909\u7570\u304c\u3042\u3063\u3066\u3082\u306a\u304f\u3066\u3082\uff0c\u7d50\u5c40\u306f\u624b\u8853\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\u3092\u3057\u307e\u3059<\/li>\n<li>\u30aa\u30ea\u30b4\u306f\u9577\u671f\u751f\u5b58\u304c\u671f\u5f85\u3067\u304d\u308b\u306e\u3067\uff0c\u3064\u3089\u3044\u5f8c\u907a\u75c7\u3092\u6b8b\u3059\u3088\u3046\u306a\u7121\u7406\u306a\u624b\u8853\u306f\u3057\u307e\u305b\u3093<\/li>\n<li>\u65e5\u672c\u3067\u306e\u30b0\u30ec\u30fc\u30c9\uff13\u3078\u306e\u653e\u5c04\u7dda\u6cbb\u7642\u306f\uff0c60\u30b0\u30ec\u30a4\uff081\u65e5\u7dda\u91cf2\u30b0\u30ec\u30a4\uff09\u3067\u3059\u304c\uff0c\u3053\u308c\u306f\u6cbb\u308b\u671f\u5f85\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u306b\u306f\u660e\u3089\u304b\u306b\u5f37\u3059\u304e\u3067\u3057\u3087\u3046<\/li>\n<li>\u6cbb\u7642\u5f8c\u306b\u9577\u671f\u751f\u5b58\u3057\u305f\u60a3\u8005\u3055\u3093\u3092\u898b\u3066\u3044\u308b\u3068\uff0c\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3067\u793e\u4f1a\u5fa9\u5e30\u3067\u304d\u306a\u304f\u306a\u308b\u3053\u3068\u3082\u591a\u3044\u3067\u3059<\/li>\n<li>\u30e8\u30fc\u30ed\u30c3\u30d1\u306e1\u65e5\u7dda\u91cf\u306f1.8\u30b0\u30ec\u30a4\u3067\u3059\u304b\u3089\u305d\u308c\u306b\u6e96\u3058\u308b\u3079\u304d\u3067\u3059<\/li>\n<li>\u307e\u305f\uff0c60\u30b0\u30ec\u30a4\u3068\u3044\u3046\u306e\u306f\u81a0\u82bd\u816b\u306b\u4f7f\u7528\u3055\u308c\u308b\u7dda\u91cf\u3067\u3059\u304b\u3089\uff0c\u9577\u671f\u751f\u5b58\u3092\u671f\u5f85\u3059\u308b\u30b0\u30ec\u30fc\u30c93\u306e\u5834\u5408\u306b\u306f\uff0c<strong><span style=\"color: #000080;\">50-54\u30b0\u30ec\u30a4\u7a0b<\/span><\/strong>\uff081\u65e5\u7dda\u91cf1.8\u30b0\u30ec\u30a4\uff0c27-30\u5206\u5272\uff09\u304c\u9069\u5207\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u3053\u306e20\u5e74\u9593\u304f\u3089\u3044\u306f\u305d\u3046\u3057\u3066\u6cbb\u7642\u3057\u3066\u304d\u307e\u3057\u305f\u3057\uff0c\u3044\u307e\u3067\u3082\u3053\u306e\u8003\u3048\u306f\u5909\u308f\u308a\u307e\u305b\u3093<\/li>\n<li>\u4e0d\u8981\u306a\u90e8\u5206\u306b\u653e\u5c04\u7dda\u969c\u5bb3\u3092\u907f\u3051\u308b\u305f\u3081\u306b\uff0c\u5927\u304d\u306a\u816b\u760d\u306e\u5834\u5408\u306e\u7167\u5c04\u65b9\u6cd5\u306fIMRT\u3092\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<li>\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u3048\u3066\u526f\u4f5c\u7528\u3082\u8efd\u3044\uff0c<span style=\"color: #000080;\"><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306e\u4f75\u7528\u304c\u65e5\u672c\u306e\u73fe\u72b6\u3067\u306f\u6700\u3082\u9069\u5207<\/strong><\/span>\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059<\/li>\n<li>1p\/19q\u6b20\u5931\u304c\u3042\u308b\u4f8b\u3067\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u3060\u304b\u3089\u3068\u3044\u3063\u3066\uff0c\u6b20\u5931\u304c\u306a\u3044\u4f8b\u3067\u5316\u5b66\u7642\u6cd5\u3092\u4f7f\u7528\u3057\u306a\u3044\u304b\u3068\u3044\u3046\u3068\uff0c\u4f7f\u7528\u3057\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u30892016\u5e74\u6642\u70b9\u3067\u306f\uff0c1p\/19q\u6b20\u5931\u304c\u3042\u308b\u304b\u306a\u3057\u304b\u3067\u5316\u5b66\u7642\u6cd5\u306e\u9078\u629e\u80a2\u306f\u5909\u308f\u308a\u307e\u305b\u3093<\/li>\n<li>1p\/19q\u6b20\u5931\u304c\u3042\u308b\u4f8b\u3067\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u6cbb\u7642\u306e\u30c8\u30ec\u30f3\u30c9\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3053\u306e\u6cbb\u7642\u306e\u5371\u967a\u6027\u306f\u3042\u308b\u7a0b\u5ea6\u306e\u671f\u9593\u306f\u816b\u760d\u9032\u884c\u304c\u6291\u3048\u3089\u308c\u308b\u306e\u3067\u3059\u304c\uff0c\u307b\u3068\u3093\u3069\u306e\u4f8b\u3067\u30d6\u30ec\u30a4\u30af\u304c\u751f\u3058\u3066\u7d50\u679c\u7684\u306b\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u30b0\u30ec\u30fc\u30c93\u3067\u6cbb\u7652\u3068\u3044\u3046\u3082\u306e\u3092\u76ee\u6307\u3059\u306e\u3067\u3042\u308c\u3070\uff0c\u521d\u671f\u6cbb\u7642\u3067\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u3092\u4f75\u7528\u3057\u305f\u65b9\u304c\u6cbb\u308b\u78ba\u7387\u304c\u9ad8\u3044\u306e\u3067\u3059<\/li>\n<li>\u653e\u5c04\u7dda\u969c\u5bb3\u304c\u304b\u306a\u308a\u5927\u304d\u304f\u306a\u308b\u3068\u5224\u65ad\u3055\u308c\u308b\u5e83\u7bc4\u56f2\u9032\u5c55\u816b\u760d\u4f8b\u3067\u304b\u30641p\/19q\u6b20\u5931\u3042\u308c\u3070\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5358\u72ec\u521d\u671f\u6cbb\u7642\u3092\u9078\u629e\u3059\u308b\u306e\u3082\u3088\u3044\u3067\u3057\u3087\u3046\u3057\uff0c\u7dda\u91cf\u3092\u843d\u3068\u3057\u3066boost\u306e\u7bc4\u56f2 margin \u3092\u7d5e\u308a\u307e\u3059<\/li>\n<li>\u30ac\u30c9\u30ea\u30cb\u30a6\u30e0\u5897\u5f37\u3055\u308c\u308b\u90e8\u5206\u3068\u58ca\u6b7b\u304c\u591a\u304f\uff0c1p\/19q\u6b20\u5931\u304c\u306a\u304f\uff0c\u5897\u6b96\u901f\u5ea6\u304c\u901f\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u661f\u7d30\u80de\u816bAOA NOS \u3067\u306f\u30a2\u30d0\u30b9\u30c1\u30f3\u3092\u4f75\u7528\u3057\u305f\u65b9\u304c\u3044\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093<\/li>\n<li>\u3053\u3046\u3044\u3046\u306e\u306f\u30aa\u30ea\u30b4\u3068\u3044\u3063\u3066\u3082\u81a0\u82bd\u816b\u306b\u8fd1\u3044\u6027\u683c\u3092\u6709\u3057\u307e\u3059<\/li>\n<\/ul>\n<p><a href=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltwin5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-7722\" src=\"\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltwin5-300x212.jpg\" alt=\"owltwin5\" width=\"300\" height=\"212\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltwin5-300x212.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltwin5-550x389.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/wp\/wp-content\/uploads\/2012\/04\/owltwin5.jpg 1134w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e4f\u7a81\u8d77\u81a0\u816b\uff08\u307c\u3046\u3068\u3063\u304d\u3053\u3046\u3057\u3085\uff09\u306f\uff0c\u30b0\u30ea\u30aa\u30fc\u30de\uff08\u795e\u7d4c\u81a0\u816b\uff09\u3068\u547c\u3070\u308c\u308b\u8133\u816b\u760d\u306e\u4e00\u7a2e\u3067\u3059 \u696d\u754c\u7528\u8a9e\u3067\u307e\u3068\u3081\u3066\u30aa\u30ea\u30b4\u3068\u3044\u3044\u307e\u3059 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-136","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=136"}],"version-history":[{"count":229,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/136\/revisions"}],"predecessor-version":[{"id":23757,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/136\/revisions\/23757"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}