{"id":10499,"date":"2018-04-06T08:42:13","date_gmt":"2018-04-05T23:42:13","guid":{"rendered":"http:\/\/plaza.umin.ac.jp\/sawamura\/?p=10499"},"modified":"2023-12-11T17:04:53","modified_gmt":"2023-12-11T08:04:53","slug":"epitheloid-glioblastoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/glioma\/epitheloid-glioblastoma\/","title":{"rendered":"\u985e\u4e0a\u76ae\u81a0\u82bd\u816b epitheloid glioblastoma"},"content":{"rendered":"<ul>\n<li><strong><span style=\"color: #000080;\">\u5c0f\u5150\u3068\u82e5\u3044\u6210\u4eba<\/span><\/strong>\u306b\u767a\u751f\u3057\u307e\u3059<\/li>\n<li>WHO\u30b0\u30ec\u30fc\u30c9\uff14\u3067\uff0c\u81a0\u82bd\u816b\u3088\u308a\u3082\u3055\u3089\u306b\u60aa\u6027\u5ea6\u304c\u60aa\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u9593\u8133\uff08\u8996\u5e8a\uff0c\u8996\u5e8a\u4e0b\u90e8\uff09<\/strong><\/span>\u306b\u597d\u767a\u3057\u307e\u3059\uff0c\u5927\u8133\u8868\u9762\u306b\u3082\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>MRI\u753b\u50cf\u306f\uff0c\u81a0\u82bd\u816b\u3068\u3068\u3066\u3082\u4f3c\u3066\u3044\u307e\u3059<\/li>\n<li>\u7279\u5fb4\u3068\u3057\u3066\uff0c\u816b\u760d\u5185\u51fa\u8840\u304c\u307f\u3089\u308c\uff0c\u767a\u75c7\u6642\u306b\u3059\u3067\u306b\u9ac4\u819c\u6d78\u6f64\u304c\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u9ad8\u7387\u306b\u9ac4\u6db2\u64ad\u7a2e<\/span><\/strong>\u3057\u307e\u3059<\/li>\n<li>\u5168\u8eab\u8ee2\u79fb\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><strong><span style=\"color: #000080;\">\u751f\u547d\u4e88\u5f8c\u306f\u4e0d\u826f\u3067\u534a\u5e74\u304f\u3089\u3044<\/span><\/strong>\u3068\u8a00\u308f\u308c\u307e\u3059<\/li>\n<\/ul>\n<h4>\u75c5\u7406<\/h4>\n<ul>\n<li>\u81a0\u82bd\u816b\u306b\u4f3c\u305f\u75c5\u7406\u50cf\u3067\u3059<\/li>\n<li>\u7a81\u8d77\u306e\u306a\u3044\u597d\u9178\u6027\u80de\u4f53\u3092\u6709\u3059\u308b\u5927\u304d\u306aepitheloid cells\uff0c\u7a7a\u80de\u5316\u3057\u305f\u30af\u30ed\u30de\u30c1\u30f3\u3068\u660e\u77ad\u306a\u6838\u5c0f\u4f53\u304c\u7279\u5fb4\u3067\u3059<\/li>\n<li>\u30e9\u30d6\u30c9\u30a4\u30c9\u81a0\u82bd\u816b rhabdoid glioblastoma\u306b\u3082\u985e\u4f3c\u3059\u308b\u7d44\u7e54\u50cf\u3067\uff0c\u540c\u4e00\u8996\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059 (epithelioid\/rhabdoid \u00a0GBM)<\/li>\n<li>pleomorphic xanthoastrocyotoma\u306b\u6df7\u5728\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>epithelial gliblastoma\u3068\u3044\u3046\u306e\u306f\u307e\u305f\u7570\u306a\u3063\u305f\u75c5\u7406\u8a3a\u65ad\u3067\u3042\u308a\uff0c\u6210\u4eba\u306b\u767a\u751f\u3057\u3066\u4e0a\u76ae\u69d8\u5206\u5316 squamous epithelial differentiation\u3092\u793a\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u534a\u6570\u304f\u3089\u3044\u306bBRAF V600E\u907a\u4f1d\u5b50\u5909\u7570<\/strong><\/span>\u3092\u307f\u307e\u3059<\/li>\n<\/ul>\n<h4>\u6cbb\u7642<\/h4>\n<ul>\n<li>\u81a0\u82bd\u816b\u306b\u6e96\u305a\u308b\u6cbb\u7642\u304c\u306a\u3055\u308c\u307e\u3059<\/li>\n<li>\u958b\u982d\u624b\u8853\u306b\u3088\u308b\u6458\u51fa<\/li>\n<li>\u5c40\u6240\u653e\u5c04\u7dda\u6cbb\u7642 60\u30b0\u30ec\u30a4<\/li>\n<li><strong><span style=\"color: #000080;\">\u5f93\u6765\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u306e\u3082\u306e\u306b\u306f\uff0cBRAF\u963b\u5bb3\u5264\u306e\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\uff08\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6)\u3068\u30e1\u30ad\u30cb\u30b9\u30c8\uff08\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff09\u306e\u4f75\u7528\u6295\u4e0e\u304c\u4fdd\u967a\u8a3a\u7642\u3067\u3067\u304d\u307e\u3059<\/span><\/strong><\/li>\n<li><span style=\"color: #333333;\">BRAF v600\u907a\u4f1d\u5b50\u306b\u5909\u7570\u306e\u3042\u308b\u4f8b\u3067\uff0c<\/span><strong><span style=\"color: #000080;\">\u30bf\u30d5\u30a3\u30f3\u30e9\u30fc\u30ab\u30d7\u30bb\u30eb\uff08<\/span><\/strong><strong style=\"color: #000080;\">\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\uff0cBRAF\u963b\u5bb3\u5264\uff09\uff0c\u30e1\u30ad\u30cb\u30b9\u30c8\u9320\uff08<\/strong><strong style=\"color: #000080;\">\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\uff0cMEK\u963b\u5bb3\u5264\uff09<\/strong><span style=\"color: #333333;\">\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3082\u306e\u3067\u3059<\/span><\/li>\n<\/ul>\n<h5 class=\"heading-title\">\u6587\u732e<\/h5>\n<h4 class=\"heading-title\">vemurafenib\u304c\u6709\u52b9\u3067\u3042\u3063\u305f<\/h4>\n<p class=\"heading-title\">Lin Z : Effective treatment of a BRAF V600E-mutant epithelioid glioblastoma patient by vemurafenib: a case report. Anticancer Drugs 2022<br \/>\n37\u6b73\u7537\u6027\u3067\uff0cBRAFv600E\u3068TERT\u306e\u5909\u7570\u304c\u3042\u308a\u307e\u3057\u305f\u3002IDH wild-type\u3067\u3059\u3002vemurafenib\u304c\u6295\u4e0e\u3055\u308c\u624b\u8853\u5f8c\u6b8b\u5b58\u816b\u760d\u304c15\u30f6\u6708\u5897\u5927\u3057\u306a\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002<\/p>\n<h4>BRAF\u3068MEK-1\/2\u963b\u5bb3\u5264\u306e\u52b9\u679c<\/h4>\n<p class=\"heading-title\">Venkatesh A: Response to BRAF and MEK1\/2 inhibition in a young adult with BRAF V600E mutant epithelioid glioblastoma multiforme: A Case Report and Litera<span style=\"text-decoration: underline;\">t<\/span>ure Review. Current Probl Cancer 2021<br \/>\ndabrafenib and trametinib\u306e\u6cbb\u7642\u3067\u9577\u671f\u306e\u594f\u529f\u304c\u3042\u3063\u305f\u3068\u306e\u75c7\u4f8b\u5831\u544a\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5c0f\u5150\u3068\u82e5\u3044\u6210\u4eba\u306b\u767a\u751f\u3057\u307e\u3059 WHO\u30b0\u30ec\u30fc\u30c9\uff14\u3067\uff0c\u81a0\u82bd\u816b\u3088\u308a\u3082\u3055\u3089\u306b\u60aa\u6027\u5ea6\u304c\u60aa\u3044\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3059 \u9593\u8133\uff08\u8996\u5e8a\uff0c\u8996\u5e8a\u4e0b\u90e8\uff09\u306b\u597d\u767a\u3057\u307e\u3059\uff0c\u5927\u8133\u8868\u9762\u306b\u3082\u307f\u3089\u308c\u307e\u3059 MRI\u753b\u50cf\u306f\uff0c\u81a0\u82bd\u816b\u3068\u3068\u3066\u3082\u4f3c\u3066\u3044\u307e\u3059 \u7279\u5fb4\u3068\u3057\u3066\uff0c\u816b\u760d\u5185\u51fa\u8840\u304c\u307f [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-10499","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/10499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/comments?post=10499"}],"version-history":[{"count":10,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/10499\/revisions"}],"predecessor-version":[{"id":22092,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/posts\/10499\/revisions\/22092"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/media?parent=10499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/categories?post=10499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/wp-json\/wp\/v2\/tags?post=10499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}