{"id":3884,"date":"2013-09-06T18:56:00","date_gmt":"2013-09-06T09:56:00","guid":{"rendered":"\/sawamura\/blog\/?p=3884"},"modified":"2023-05-30T14:05:53","modified_gmt":"2023-05-30T05:05:53","slug":"craniopharyngiomapathology","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/pathocase\/craniopharyngiomapathology\/","title":{"rendered":"\u982d\u84cb\u54bd\u982d\u816b\u306e\u75c5\u7406 craniopharyngioma"},"content":{"rendered":"<h5>craniopharyngioma \u00a0WHO grade 1<\/h5>\n<ul>\n<li><strong><span style=\"color: #000080;\"><a href=\"\/sawamura\/blog\/braintumors\/cranio\/\">\u982d\u84cb\u54bd\u982d\u816b<\/a><\/span><\/strong>\u306b\u306f\uff0c5-15\u6b73\uff08\u5c0f\u5150\uff09\u306e\u30d4\u30fc\u30af\u306845-60\u6b73\uff08\u6210\u4eba\uff09\u306e\u30d4\u30fc\u30af\u306e2\u3064\u306e\u597d\u767a\u5e74\u9f62\u5c64\u304c\u3042\u308a\u307e\u3059\u3002\u4e73\u5150\u3092\u542b\u3081\u3066\u5168\u3066\u306e\u5e74\u9f62\u3067\u898b\u3089\u308c\u307e\u3059\u3002\u539f\u767a\u6027\u8133\u816b\u760d\u306e0.5-2.5\uff05\u3068\u73cd\u3057\u3044\u816b\u760d\u3068\u8a00\u3048\u307e\u3059\u304c\uff0c14\u6b73\u4ee5\u4e0b\u306e\u5c0f\u5150\u3067\u306f5-10\uff05\u3092\u5360\u3081\u5c0f\u5150\u8133\u816b\u760d\u3068\u3057\u3066\u306f\u591a\u3044\u90e8\u985e\u306e\u75be\u60a3\u3067\u3059\u3002<\/li>\n<li>\u767a\u751f\u6bcd\u5730\u306f\uff0c\u9686\u8d77\u90e8 pars tuberalis\u306eRathke pouch\u3068\u547c\u3070\u308c\u308b\u985e\u4e0a\u76ae\u306e\u61a9\u5ba4\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u90e8\u4f4d\u306f\u795e\u7d4c\u4e0b\u5782\u4f53 neurohypophysis\u3067\u3042\u308a\uff0c\u7b2c\uff13\u8133\u5ba4\u5e95\uff08\u8996\u5e8a\u4e0b\u90e8\u7070\u767d\u9686\u8d77 tuber cinereum)\uff0c\u4e0b\u5782\u4f53\u67c4 (pituitary stalk)\uff0c\u4e0b\u5782\u4f53\u4e2d\u9593\u8449\u5f8c\u8449 (pars intermedialis, posterior lobe)\u306e\u8d77\u6e90\u306e\u3044\u305a\u308c\u304b\u3068\u306a\u308a\u307e\u3059\u3002\u81e8\u5e8a\u7684\u306b\u3082\uff0c\u3053\u306e\u767a\u751f\u90e8\u4f4d\u306b\u3088\u3063\u3066\u816b\u760d\u306e\u5b58\u5728\u90e8\u4f4d\u3068\u4f38\u5c55\u65b9\u5411\u304c\u7570\u306a\u308a\u307e\u3059\u3002<\/li>\n<li>\u75c5\u7406\u5b66\u7684\u306b\u306f\uff0cadamantinomatous type \u3068 papillary type\u306e2\u3064\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u304c\uff0cpapillary type\u306f\u6210\u4eba\u306b\u3057\u304b\u767a\u751f\u3057\u307e\u305b\u3093\u3002\u5f93\u3063\u3066\uff0cadamantinomatous type\u304c\u5727\u5012\u7684\u306b\u591a\u3044\u3068\u3044\u3048\u307e\u3059\u3002adamantinomatous type\u306fneoplastic transformation of primitive craniopharyngeal duct remnant\u304b\u3089\uff0cpapillary type\u306fanterior pituitary cell metaplasia\u3068\u3044\u3046\u610f\u898b\u3082\u3042\u308a\u307e\u3059\u304c\uff0c\u78ba\u5b9a\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u8aac\u3067\u306f\uff0cpapillary type\u304c\u7b2c\uff13\u8133\u5ba4\u306b\u591a\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u8aac\u660e\u3067\u304d\u306a\u3044\u3067\u3059\u3002<\/li>\n<li>papillary type\u306f<span style=\"color: #000080;\"><strong>BRAF mutation<\/strong><\/span>\uff0c<span style=\"color: #ff0000;\">adamantinomatous type\u306f<strong>CTNNB1 mutation<\/strong><\/span>\u304c\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li>\n<\/ul>\n<h4>\u81e8\u5e8a\u7684\u306b\u5927\u5207\u306a\u3053\u3068<\/h4>\n<p><span style=\"color: #333333;\">\u982d\u84cb\u54bd\u982d\u816b<\/span>\u306f\u5883\u754c\u660e\u77ad\u306a\u826f\u6027\u816b\u760d\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u75c5\u7406\u5b66\u7684\u306b\u306f\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<span style=\"color: #000080;\"><strong><a href=\"\/sawamura\/blog\/braintumors\/cranio\/\">\u982d\u84cb\u54bd\u982d\u816b<\/a>\u306f\u5468\u56f2\u306e\u6b63\u5e38\u7d44\u7e54\u306b\u98df\u3044\u8fbc\u3080\u3088\u3046\u306b\u6f5c\u308a\u8fbc\u3093\u3067\u5897\u6b96\u3057\u307e\u3059<\/strong><\/span>\u3002\u4f8b\u3048\u3070\uff0c\u8996\u5e8a\u4e0b\u90e8\u8133\u7d44\u7e54\u306b\u6d78\u6f64\u3067\u306f\u306a\u304f\u3066\u4fb5\u5165\u3057\u7652\u7740\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3092\u8996\u5e8a\u4e0b\u90e8\u304b\u3089\u5265\u96e2\u3057\u3066\u5b8c\u5168\u306b\u6458\u51fa\u3057\u3088\u3046\u3068\u3059\u308c\u3070\uff0c\u8996\u5e8a\u4e0b\u90e8\u640d\u50b7\u306f\u907f\u3051\u5f97\u307e\u305b\u3093\u3002<\/p>\n<h4>adamantinomatous type\uff08\u307b\u3068\u3093\u3069\u3053\u306e\u30bf\u30a4\u30d7\uff09<\/h4>\n<p>\u30a8\u30ca\u30e1\u30eb\u4e0a\u76ae\u816b\u578b\u3068\u3044\u3044\u307e\u3059\u3002\u7d44\u7e54\u5b66\u7684\u306b\u306fwet keratin\u3092\u542b\u3080\u3053\u3068\u304c\u7279\u5fb4\u3067\uff0c\u3053\u306e\u6240\u898b\u3067papillary type\u3068\u533a\u5225\u304c\u3067\u304d\u307e\u3059\u3002\u57fa\u5e95\u5c64\u304c\u4e00\u5217\u306b\u914d\u5217\u3057\uff0c\u305d\u308c\u306b\u7d9a\u3044\u3066\u4e0a\u76ae\u7d30\u80de\u304c\u3042\u308a\uff0c\u4e00\u90e8\u306b\u758e\u306a\u7d50\u5408\u8077\u3068\u5c0f\u8840\u7ba1\u306e\u90e8\u5206\uff0c\u77f3\u7070\u5316\uff0c\u5c0f\u306e\u3046\u80de\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u306e\u3046\u80de\u5185\u5bb9\u6db2\u306f\uff0c\u8089\u773c\u7684\u306b\u6697\u7dd1\u8910\u8272\u3067machinery oil\u3068\u8868\u73fe\u3055\u308c\u308b\u3002\u8133\u7d44\u7e54\uff08\u7279\u306b\u8996\u5e8a\u4e0b\u90e8\uff09\u306b\u6d78\u6f64\u3057\uff0c\u795e\u7d4c\u3084\u8840\u7ba1\u306b\u7652\u7740\u3057\u307e\u3059\u3002<a title=\"\u982d\u84cb\u54bd\u982d\u816b\u306e\u9aa8\u5316\" href=\"\/sawamura\/blog\/pediattumor\/craniopharyngiomaossification\/\">\u307e\u308c\u306b\u77f3\u7070\u5316\u3067\u306f\u306a\u304f\uff0c\u771f\u306e\u9aa8\u5316\u304c\u307f\u3089\u308c\u308b\u3002<\/a><\/p>\n<h6>adanmantinomatous type \u4e3b\u8981\u6240\u898b (by Dr. \u7d99\u4ec1\uff09<\/h6>\n<ul>\n<li>palisaded columnar epithelium<\/li>\n<li>stellate reticulum cells<\/li>\n<li>wet keratin \/ carcification<\/li>\n<li>whorl formation<\/li>\n<li>cystic degeneration<\/li>\n<li>xanthogranulomatous change<\/li>\n<\/ul>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe21.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-3905 alignleft\" title=\"cranionmhe2\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe21-550x419.jpg\" alt=\"\" width=\"550\" height=\"419\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe21-550x419.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe21-300x228.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe21.jpg 992w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>Scarce squamous epithelium with basal vascular network of cyst wall<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-3906 alignleft\" title=\"cranionmhe1\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe1-550x419.jpg\" alt=\"\" width=\"550\" height=\"419\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe1-550x419.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe1-300x228.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionmhe1.jpg 992w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><br \/>\n<\/a><\/p>\n<p>&#8220;Wet keratin&#8221; in an epithelial layer.<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/cranio-tag1.png\"><img loading=\"lazy\" decoding=\"async\" title=\"cranio-tag1\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/cranio-tag1.png\" alt=\"\" width=\"500\" height=\"406\" \/><\/a><br \/>\nCraniopharyngioma with wet keratin structures (upper left) and calcification (upper right).<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioirhe1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-4760\" title=\"cranioirhe\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioirhe1-550x412.jpg\" alt=\"\" width=\"550\" height=\"412\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioirhe1-550x412.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioirhe1-300x225.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioirhe1.jpg 850w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>Adamantinomatous craniopharyngioma showing well-differenciated squamous epithelium including whorl of squamous cells. MIB-1 index of the dense basal layer was approximately 10%.<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/craniocholesterol1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-4484\" title=\"craniocholesterol\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/craniocholesterol1-550x468.jpg\" alt=\"\" width=\"550\" height=\"468\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/craniocholesterol1-550x468.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/craniocholesterol1-300x255.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/craniocholesterol1.jpg 794w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>Xanthogranulomatous part in an adamantinomatous craniopharyngioma showing cholesterol clefts (upper left) surrounded by collagen tissue, dense macrophage infiltration, and lymphatic infiltrates (upper right)<\/p>\n<h4>\u8996\u5e8a\u4e0b\u90e8\u6d78\u6f64\uff08\u3088\u304f\u3042\u308b\u3053\u3068\u3067\u91cd\u8981\uff09<\/h4>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/craniotag1.jpg\"><img loading=\"lazy\" decoding=\"async\" title=\"craniotag1\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/craniotag1.jpg\" alt=\"\" width=\"454\" height=\"416\" \/><\/a><br \/>\nAdamantinomatous craniopharyngioma invading brain tissue. This type of hypothalamic invasion is frequently seen in the suprasellar\/ intraventricular craniopharyngioma.<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-10257\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka-550x531.jpg\" alt=\"\" width=\"550\" height=\"531\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka-550x531.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka-300x290.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka-768x742.jpg 768w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranionaka.jpg 787w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>The border between tumor cells forming lateral palisading (center) and hypothalamic glial tissue (upper right) is not clear. There is no cleavage plane.<\/p>\n<h4>adamantinomatous type\u306efinger-like protrusion<\/h4>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/craniopapi1.jpg\"><img loading=\"lazy\" decoding=\"async\" title=\"craniopapi\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/04\/craniopapi1-550x548.jpg\" alt=\"\" width=\"440\" height=\"438\" \/><\/a><br \/>\nAdamantinomatous craniopharyngioma showing surface finger (tongue)-like protrusion contains small cysts, wet keratin, and stellate reticulum.<\/p>\n<h4>\u9aa8\u5316 ossification \uff08\u307e\u308c\u3060\u3051\u3069\u5927\u5207\u306a\u6240\u898b\uff09<\/h4>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi51.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-6544\" title=\"cranioossi5\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi51-550x380.jpg\" alt=\"\" width=\"550\" height=\"380\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi51-550x380.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi51-300x207.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi51.jpg 945w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi62.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-6545\" title=\"cranioossi6\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi62-550x488.jpg\" alt=\"\" width=\"550\" height=\"488\" srcset=\"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi62-550x488.jpg 550w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi62-300x266.jpg 300w, https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-content\/uploads\/2013\/09\/cranioossi62.jpg 799w\" sizes=\"auto, (max-width: 550px) 100vw, 550px\" \/><\/a><\/p>\n<p>A large piece of mature bone in a suprasellar craniopharyngioma.<\/p>\n<h4>\u6587\u732e<\/h4>\n<ul>\n<li>Brastianos PK, et al.: Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 46: 161-165, 2014<\/li>\n<li>Sekine S, et al.: Craniopharyngiomas of adamantinomatous type harbar beta-catenin gene mutations. Am J Pathol 161: 197-2001,, 2002<\/li>\n<li>Buslei R, et al.: Common mutations of beta-catenin in adamantinomatous craniopharyngioma but not in other tumors originating from the seller region. Acta Neuropathol 109: 589-597, 2005<\/li>\n<li>\u7d99\u4ec1, et al.: \u8133\u795e\u7d4c\u5916\u79d1\u533b\u306e\u305f\u3081\u306e\uff0c\u982d\u84cb\u54bd\u982d\u816b\u306e\u75c5\u7406\u304b\u3089\u898b\u305f\u81e8\u5e8a, \u8133\u795e\u7d4c\u5916\u79d1\u901f\u5831, 2009<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>craniopharyngioma \u00a0WHO grade 1 \u982d\u84cb\u54bd\u982d\u816b\u306b\u306f\uff0c5-15\u6b73\uff08\u5c0f\u5150\uff09\u306e\u30d4\u30fc\u30af\u306845-60\u6b73\uff08\u6210\u4eba\uff09\u306e\u30d4\u30fc\u30af\u306e2\u3064\u306e\u597d\u767a\u5e74\u9f62\u5c64\u304c\u3042\u308a\u307e\u3059\u3002\u4e73\u5150\u3092\u542b\u3081\u3066\u5168\u3066\u306e\u5e74\u9f62\u3067\u898b\u3089\u308c\u307e\u3059\u3002\u539f\u767a\u6027\u8133\u816b\u760d\u306e0.5 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-3884","post","type-post","status-publish","format-standard","hentry","category-pathocase"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/3884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/comments?post=3884"}],"version-history":[{"count":55,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/3884\/revisions"}],"predecessor-version":[{"id":21612,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/3884\/revisions\/21612"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/media?parent=3884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/categories?post=3884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/tags?post=3884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}