{"id":10512,"date":"2018-04-08T09:06:13","date_gmt":"2018-04-08T00:06:13","guid":{"rendered":"http:\/\/plaza.umin.ac.jp\/sawamura\/blog\/?p=10512"},"modified":"2018-04-14T08:16:09","modified_gmt":"2018-04-13T23:16:09","slug":"childglioblastoma","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/glioma\/childglioblastoma\/","title":{"rendered":"\u5c0f\u5150\u306e\u81a0\u82bd\u816b glioblastoma of children, pediatric GBM"},"content":{"rendered":"
2016\u5e74\u304b\u3089\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u50cf\u304c\u81a0\u82bd\u816b\u3067\u3042\u3063\u3066\u3082\uff0chiston H3 K27M\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u81a0\u82bd\u816b\u3068\u547c\u3070\u305a\u306b\u300c\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<\/a><\/span>\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f<\/h5>\n
    \n
  • \u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e20%\u7a0b\u5ea6\u3067\u3042\u308a\u3001\u6210\u4eba\u306e\u5272\u5408\u3088\u308a\u4f4e\u3044\u3067\u3059<\/li>\n
  • \u5206\u5b50\u907a\u4f1d\u5b66\u7684\u306a\u767a\u751f\u6a5f\u5e8f\u3001\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3078\u306e\u611f\u53d7\u6027\u3001\u4e88\u5f8c\u306b\u304a\u3044\u3066\u6210\u4eba\u306e\u81a0\u82bd\u816b\u3068\u9055\u3044\u304c\u3042\u308a\u307e\u3059<\/li>\n
  • \u5c0f\u5150\u306e\u81a0\u82bd\u816b\u306e5\u5e74\u751f\u5b58\u5272\u5408\u306f20%\u7a0b\u5ea6<\/strong><\/span>\u3067\u6210\u4eba\u3068\u3055\u307b\u3069\u306e\u9055\u3044\u306f\u3042\u308a\u307e\u305b\u3093<\/li>\n
  • \u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f1\u5e74\u534a\u307b\u3069\u3067\u3059<\/li>\n
  • 5\u6b73\u4ee5\u4e0b\u306e\u5b50\u4f9b\u305f\u3061\u306f\u751f\u5b58\u671f\u9593\u304c\u9577\u3044<\/span><\/strong>\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n
  • \u305f\u3060\u3057\u3001PNET\u3068\u306e\u6df7\u5728\u306a\u3069\u75c5\u7406\u8a3a\u65ad\u306e\u554f\u984c\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u7a00\u306b10\u5e74\u8fd1\u3044\u8d85\u9577\u671f\u751f\u5b58\u4f8b\u306e\u5831\u544a\u304c\u3042\u308b<\/strong><\/span>\u70b9\u304c\u3001\u6210\u4eba\u3068\u306f\u7570\u306a\u308a\u307e\u3059<\/li>\n
  • \u6cbb\u7642\u65b9\u6cd5\u306f\u6210\u4eba\u3068\u540c\u3058\u3067\uff0c\u624b\u8853\uff0c\u653e\u5c04\u7dda\u6cbb\u7642\uff0c\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u5316\u5b66\u7642\u6cd5\u3067\u3059<\/li>\n
  • \u5c0f\u5150\u306b\u304a\u3044\u3066\u3082\u30c6\u30e2\u30be\u30ed\u30de\u30a4\u30c9\u306f\u6709\u52b9\u3068\u3055\u308c\u307e\u3059<\/li>\n
  • \u3067\u3082\u3068\u3066\u3082\u5e7c\u3044\u5b50\u4f9b\u306b\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u7528\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093<\/li>\n
  • 11\u6b73\u304b\u308919\u6b73\u306e\u5b50\u4f9b\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306f\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3057\u307e\u3059<\/li>\n
  • \u9006\u306b\uff0c10\u6b73\u4ee5\u4e0b\u3067<\/strong><\/span>\u8996\u5e8a\u8133\u5e79\u90e8\u8fd1\u508d\u306b\u767a\u751f\u3057\u305f\u4f8b\u3067\u306f\u653e\u5c04\u7dda\u6cbb\u7642\u306e\u52b9\u679c\u304c\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u307e\u305b\u3093<\/span><\/strong><\/li>\n
  • BRAF V600E<\/strong><\/span>\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u5c0f\u5150\u81a0\u82bd\u816b\u306b\u306f\uff0c\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6<\/strong><\/span> BRAF\u00a0inhibitor<\/span> vemurafenib<\/span><\/strong>\u304c\u6709\u52b9\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059<\/li>\n<\/ul>\n
    \u6210\u4ebaGBM\u3068\u9055\u3046\u3068\u3053\u308d<\/h5>\n
      \n
    • 40%\u304f\u3089\u3044\u3067\u6210\u4eba\u3068\u7570\u306a\u308b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308a\uff0c\u4e88\u5f8c\u304c\u826f\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n
    • histon H3\u5909\u7570\u306e\u3042\u308b\u3082\u306e\u306f\u4e88\u5f8c\u304c\u60aa\u3044\u306e\u3067\u3059\u304c\uff0c\u3053\u308c\u306f\u81a0\u82bd\u816b\u3067\u306f\u306a\u304f\u3066\uff0c\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u3068\u547c\u3073\u307e\u3059<\/li>\n
    • secondary GBM (IDH\u5909\u7570\u578b) \u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u304c\uff0c\u601d\u6625\u671f\u5927\u8133\u534a\u7403\u3067\u307e\u308c\u306b\u307f\u3089\u308c\u307e\u3059<\/li>\n
    • \u591a\u304f\u306e\u764c\u907a\u4f1d\u5b50\u306e\u5897\u5e45\u304c\u3042\u308b\u4f8b\u3067\u306f\u4e88\u5f8c\u4e0d\u826f\u3067\u3059<\/li>\n
    • \u5de8\u7d30\u80de\u6027\u81a0\u82bd\u816b giant cell glioblastoma\u304c\u7d049%\u3042\u308a\u307e\u3059<\/li>\n
    • \u5927\u8133\u534a\u7403\u306b\u898b\u3089\u308c\u3066\u4e88\u5f8c\u4e0d\u826f\u3067\u3059<\/li>\n<\/ul>\n
      \u6ce8\u610f\u3059\u308b\u3053\u3068<\/h5>\n
        \n
      • diffuse midline glioma \u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u3092\u751f\u691c\u3059\u308b\u3068\uff0c\u81a0\u82bd\u816b\u3068\u8a3a\u65ad\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n
      • \u3067\u3082\uff0c\u75c5\u7406\u7d44\u7e54\u3067\u81a0\u82bd\u816b\u3067\u3042\u3063\u3066\u3082\u305d\u308c\u306f\u81a0\u82bd\u816b\u3067\u306f\u306a\u304f\u3066\uff0c\u5206\u5b50\u8a3a\u65ad\u3067histone H3-K27M\u306e\u5909\u7570\u304c\u3042\u308c\u3070\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de<\/strong><\/span>\u3067\u3059<\/li>\n
      • \u7279\u306b\u8133\u5e79\u90e8\u3068\u8996\u5e8a\u306e\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u3053\u306e\u8aa4\u89e3\u304c\u591a\u3044\u3067\u3057\u3087\u3046<\/li>\n
      • \u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u3067\u306f\u9577\u671f\u751f\u5b58\u304c\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093<\/li>\n<\/ul>\n
        \u6587\u732e\uff1a\u6210\u4eba\u3068\u540c\u3058\u6cbb\u7642\u304c\u3067\u304d\u308b\u4f8b\u304c\u5c11\u306a\u3044<\/h5>\n

        Liu M, et al.: National cancer database analysis of outcomes in pediatric glioblastoma. 2018
        \n19\u6b73\u307e\u3067\u306b\u81a0\u82bd\u816b\u3068\u8a3a\u65ad\u3055\u308c\u305f1,173\u4f8b\u306e\u7d71\u8a08\u3067\u3059\u300258%\u306e\u5c0f\u5150\u304c\uff0c\u624b\u8853\u30fb\u653e\u5c04\u7dda\u30fb\u5316\u5b66\u7642\u6cd5\u3092\u53d7\u3051\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u305f\u6570\u306f\u5c11\u306a\u304f\u3066\uff0c\u6210\u4eba\u3088\u308a\u304b\u306a\u308a\u4f4e\u3044\u5024\u3067\u3059\u30024%\u3067\u306f\u306a\u3093\u306e\u6cbb\u7642\u3082\u306a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

        \u6587\u732e\uff1a\u5c0f\u5150\u81a0\u82bd\u816b\u306e\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u306f\u6210\u4eba\u3068\u7570\u306a\u308b\uff0c\u4e88\u5f8c\u304c\u826f\u3044\u3082\u306e\u304c\u3042\u308b<\/h5>\n

        Korshunov A, et al.: Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathol (2015)
        \n20\u6b73\u672a\u6e80\u306e\u81a0\u82bd\u816b\u306e\u5206\u5b50\u89e3\u6790\u3067\u3059\u300220%\u3067methylation profiles\u304c\u4f4e\u60aa\u6027\u5ea6\u30b0\u30ea\u30aa\u30fc\u30de\u3084PXA \u306b\u985e\u4f3c\u3057\u3066\u3044\u3066\uff0c\u3053\u308c\u3089\u306e\u3082\u306e\u3067\u306f\uff0c\u751f\u547d\u4e88\u5f8c\u304c\u304b\u306a\u308a\u826f\u304b\u3063\u305f\u305d\u3046\u3067\u3059\u3002PXA\u69d8\u306e\u816b\u760d\u3067\u306fBRAF V600E\u5909\u7570\u3068CDKN2A\u306ehomozygous deletion\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u6b8b\u308a\u306e80%\u3067\u306f\uff0cH3.3\u3084IDH\u306e\u5909\u7570\u304c\u898b\u3089\u308c\u3066\u3044\u307e\u3059\u3002IDH\u91ce\u751f\u578b\u306f36%\u3067\u3057\u305f\u3002\u6210\u4ebaGBM\u3067\u306f\uff0cIDH\u91ce\u751f\u578b\u304c\u307b\u3068\u3093\u3069\u3067\u3042\u308b\u306e\u3068\u5bfe\u7167\u7684\u306a\u30c7\u30fc\u30bf\u3067\u3059\u3002\u8907\u6570\u306e\u764c\u907a\u4f1d\u5b50\u306e\u5897\u5e45\u304c\u3042\u308b\u3082\u306e\u306f\u4e88\u5f8c\u4e0d\u826f\u3060\u305d\u3046\u3067\u3059\u3002<\/p>\n

        \u6587\u732e\uff1a\u5316\u5b66\u7642\u6cd5\u304c\u6709\u52b9\u304b\u306f\u306f\u3063\u304d\u308a\u3057\u3066\u3044\u306a\u3044<\/h5>\n

        Sposto R, et al.: The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group. J Neurooncol. 7:165-177, 1989
        \n1989\u5e74\u306bSposto\u304cChildrens Cancer Study Group\u306e\u6210\u7e3e\u3092\u767a\u8868\u3057\u3066\uff0c\u5316\u5b66\u7642\u6cd5\u3092\u52a0\u3048\u305f\u7fa4\u306e5\u5e74\u751f\u5b58\u7387\u304c46%\uff0c\u52a0\u3048\u306a\u3044\u7fa4\u304c18%\u3067\u3042\u3063\u3066\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5dee\u3067\u3042\u3063\u305f\u3068\u3044\u3046\u7d50\u679c\u3067\u3057\u305f\u3002\u3053\u308c\u3092\u3082\u3063\u3066\u5c0f\u5150\u81a0\u82bd\u816b\u306b\u3082\u5316\u5b66\u7642\u6cd5\u3092\u4f7f\u7528\u3059\u308b\u3079\u304d\u3060\u3068\u306e\u610f\u898b\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u8aa4\u308a\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u306b\u306f\u9000\u5f62\u6210\u6027\u4e4f\u7a81\u8d77\u81a0\u816b\u306a\u3069\u3082\u6df7\u5728\u3057\u3066\u542b\u307e\u308c\u3066\u3044\u305f\u304b\u3089\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

        2016\u5e74\u304b\u3089\u306f\uff0c\u75c5\u7406\u7d44\u7e54\u50cf\u304c\u81a0\u82bd\u816b\u3067\u3042\u3063\u3066\u3082\uff0chiston H3 K27M\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u3042\u308b\u3068\u81a0\u82bd\u816b\u3068\u547c\u3070\u305a\u306b\u300c\u3073\u307e\u3093\u6027\u6b63\u4e2d\u30b0\u30ea\u30aa\u30fc\u30de\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f \u661f\u7d30\u80de\u7cfb\u816b\u760d\u306e20%\u7a0b\u5ea6\u3067\u3042\u308a\u3001\u6210\u4eba\u306e\u5272\u5408\u3088\u308a\u4f4e\u3044\u3067\u3059 \u5206 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-10512","post","type-post","status-publish","format-standard","hentry","category-glioma"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/10512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/comments?post=10512"}],"version-history":[{"count":10,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/10512\/revisions"}],"predecessor-version":[{"id":10540,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/10512\/revisions\/10540"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/media?parent=10512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/categories?post=10512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/tags?post=10512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}