{"id":101,"date":"2012-04-17T22:29:35","date_gmt":"2012-04-17T13:29:35","guid":{"rendered":"\/sawamura\/blog\/?p=101"},"modified":"2019-01-06T12:05:28","modified_gmt":"2019-01-06T03:05:28","slug":"hypothdysfunction","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/braintumors\/hypothdysfunction\/","title":{"rendered":"\u8996\u5e8a\u4e0b\u90e8\u3068\u4e0b\u5782\u4f53\u306e\u7279\u6b8a\u306a\u6a5f\u80fd\u969c\u5bb3"},"content":{"rendered":"<div class=\"setumei\">\n<ul>\n<li>\u9593\u8133\u4e0b\u5782\u4f53\u4e0d\u5168\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>\u4e0b\u5782\u4f53\u817a\u816b\u3067\u306f\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u304c\u8d77\u3053\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u304c\u8db3\u308a\u306a\u3044\u305f\u3081\u306b\u8d77\u3053\u308b\u969c\u5bb3\u306f\u3068\u3066\u3082\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u3053\u3067\u306f\u6bd4\u8f03\u7684\u3081\u305a\u3089\u3057\u3044\u3082\u306e\u3092\u66f8\u3044\u3066\u3044\u304d\u307e\u3059<\/li>\n<li>\u7279\u306b\uff0c\u8996\u5e8a\u4e0b\u90e8\u306e\u969c\u5bb3\u3067\u306f\u666e\u901a\u306e\u81e8\u5e8a\u533b\u304c\u77e5\u3089\u306a\u3044\u3053\u3068\u3082\u591a\u3044\u306e\u3067\uff0c\u5185\u5206\u6ccc\u5c02\u9580\u306e\u5148\u751f\u306b\u76f8\u8ac7\u3057\u3066\u4e0b\u3055\u3044<\/li>\n<\/ul>\n<h5><span style=\"color: #000080;\"><strong>\u30db\u30eb\u30e2\u30f3\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u533b\u7642\u8cbb\u306e\u88dc\u52a9\u306f\u300c\u7279\u5b9a\u75be\u60a3\u6cbb\u7642\u7814\u7a76\u4e8b\u696d\u300d\u306e\u5bfe\u8c61\u75be\u60a3<\/strong><\/span>\u3068\u3057\u3066\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059<\/h5>\n<h5>\u5168\u56fd\u3067\u300c\u4e0b\u5782\u4f53\u6a5f\u80fd\u969c\u5bb3\u300d\u306b\u5bfe\u3057\u3066\u88dc\u52a9\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u5730\u5143\u306e\u5f79\u6240\u3067\u8abf\u3079\u3066\u4e0b\u3055\u3044<\/h5>\n<hr \/>\n<h4><span style=\"color: #000080;\"><strong>\u80a5\u6e80\u306b\u3064\u3044\u3066\uff08\u4e0b\u5782\u4f53\u4e0d\u5168\uff09<\/strong><\/span><\/h4>\n<ul>\n<li><span style=\"color: #000000;\">\u4e0b\u5782\u4f53\u3092\u5168\u90e8\u6458\u51fa\u3057\u3066\u3057\u307e\u3063\u305f\u3068\u304d\u306b\u306f<\/span>\u9ad8\u983b\u5ea6\u306b\u80a5\u6e80\u304c\u304a\u304d\u307e\u3059<\/li>\n<li>\u305f\u304f\u3055\u3093\u98df\u3079\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u601d\u3046\u306e\u306b\u592a\u3063\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u75c7\u5019\u3067\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u3068\u306b\u304b\u304f\u4f53\u91cd\u304c\u5897\u3048\u308b<\/span><\/strong>\uff0cBMI (body mass index)\u304c\u5897\u3048\u308b\u3068\u3044\u3046\u306e\u304c\u8a3a\u65ad\u3067\u3059<\/li>\n<li>\u4e0b\u5782\u4f53\u306e\u30db\u30eb\u30e2\u30f3\u4e0d\u8db3\u3067\u306f\uff0c\u6210\u9577\u30db\u30eb\u30e2\u30f3\u6b20\u640d\uff0c\u7537\u6027\u30db\u30eb\u30e2\u30f3\u306e\u6b20\u4e4f\u3067\u3082\u80a5\u6e80\u304c\u751f\u3058\u307e\u3059<\/li>\n<li>\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30fc\u30c8\u30ea\u30eb\uff09\u3092\u904e\u91cf\u306b\u98f2\u3093\u3067\u3044\u308b\u5834\u5408\u3084\u30af\u30c3\u30b7\u30f3\u30b0\u75c5\uff08\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u304c\u7570\u5e38\u306b\u5206\u6ccc\u3055\u308c\u308b\uff09\u3067\u3082\u80a5\u6e80\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u4e0b\u5782\u4f53\u4e0d\u5168\u306e\u6cbb\u7642\u306e\u4e2d\u3067\u80a5\u6e80\u3092\u6539\u5584\u3067\u304d\u308b\u306e\u306f\uff0c\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3068\u7537\u6027\u30db\u30eb\u30e2\u30f3\u306e\u88dc\u5145\u3067\u3059<\/li>\n<\/ul>\n<h4><strong>\u8996\u5e8a\u4e0b\u90e8\u6027\u80a5\u6e80\u3000hypothalamic obesity<\/strong><\/h4>\n<ul>\n<li>\u8996\u5e8a\u4e0b\u90e8\u306e\u969c\u5bb3\u3067\u6442\u98df\u969c\u5bb3\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u8133\u816b\u760d\u306e\u5834\u5408\u306f\u4e0d\u601d\u8b70\u306a\u3053\u3068\u306b\u62d2\u98df\u306b\u306a\u308b\u3053\u3068\u306f\u5c11\u306a\u3044\u3067\u3059<\/li>\n<li>\u98df\u6b32\u306e\u4e2d\u67a2\u306f\u8996\u5e8a\u4e0b\u90e8\u306e\u524d\u306e\u65b9\u306b\u3042\u3063\u3066\uff0c\u640d\u50b7\u3055\u308c\u308b\u3068<span style=\"color: #000080;\"><strong>\u5236\u5fa1\u3067\u304d\u306a\u3044\u98df\u6b32 (<\/strong><\/span><span style=\"color: #000080;\"><strong>\u904e\u98df)\u00a0<\/strong><\/span>\u304c\u751f\u3058\u307e\u3059<\/li>\n<li>\u904e\u98df\u4ee5\u5916\u306e\u80a5\u6e80\u306f\uff0c<span style=\"color: #000080;\"><strong>\u8996\u5e8a\u4e0b\u90e8\u6027\u80a5\u6e80<\/strong><\/span> hypothalamic obesity, hypothalamic injury-associated obesity \u3068\u3044\u308f\u308c\u307e\u3059<\/li>\n<li>\u3053\u306e\u5834\u5408\u306f\u5358\u306a\u308b\u904e\u98df\u3067\u306f\u306a\u304f\u3066\uff0c\u8996\u5e8a\u4e0b\u90e8\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30d0\u30e9\u30f3\u30b9\u306e\u8abf\u7bc0\u969c\u5bb3\u3067\u3059\u304c\uff0c\u306f\u3063\u304d\u308a\u3057\u305f\u539f\u56e0\u306f\u89e3\u3063\u3066\u3044\u307e\u305b\u3093<\/li>\n<li>\u30b0\u30eb\u30b3\u30fc\u30b9\uff08\u7cd6\u5206\uff09\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30fc\u30b7\u30b9\uff08\u610f\u8b58\u3057\u306a\u304f\u3066\u3082\u4f53\u304c\u81ea\u7136\u306b\u8abf\u7bc0\u3057\u3066\u304f\u308c\u308b\u3053\u3068\uff09\u304c\u304f\u305a\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u4e0b\u5782\u4f53\u969c\u5bb3\u304c\u9ad8\u5ea6\uff0c\u8996\u5e8a\u4e0b\u90e8\u306e\u640d\u50b7\u304c\u3042\u308b\uff0c\u5e74\u9f62\u304c\u4f4e\u3044\u3068\u304d\u306b\u816b\u760d\u304c\u3067\u304d\u305f\uff0c\u8996\u5e8a\u4e0b\u90e8\u306b\u9ad8\u7dda\u91cf\u306e\u653e\u5c04\u7dda\u6cbb\u7642\uff0850\u30b0\u30ec\u30a4\u4ee5\u4e0a\uff09\u304c\u3055\u308c\u305f\u306a\u3069\u304c\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u982d\u84cb\u54bd\u982d\u816b\uff0c\u6bdb\u69d8\u7d30\u80de\u6027\u661f\u7d30\u80de\u816b\uff0c\u80da\u7d30\u80de\u816b\u760d<\/strong><\/span>\uff0c\u9ac4\u82bd\u816b\u306a\u3069\u306e\u6cbb\u7642\u5f8c\u306b\u591a\u3044\u3067\u3059<\/li>\n<li>\u5927\u304d\u306a\u816b\u760d\u307b\u3069\u6cbb\u7642\u5f8c\u306e\u80a5\u6e80\u306f\u9ad8\u5ea6\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u5b50\u4f9b\u306e\u982d\u84cb\u54bd\u982d\u816b\u3067\u306f40%\u4ee5\u4e0a\u3067\u304b\u306a\u308a\u306e\u80a5\u6e80\u306b\u306a\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059<\/li>\n<li>\u592a\u3063\u3066\u3044\u308b\u304a\u6bcd\u3055\u3093\u306e\u5b50\u4f9b\u306f\u3053\u306e\u80a5\u6e80\u306b\u306a\u308a\u6613\u3044\u3068\u3082\u3055\u308c\u307e\u3059<\/li>\n<li><strong><span style=\"color: #ff0000;\">\u3053\u306e\u80a5\u6e80\u306f\u816b\u760d\u306e\u6cbb\u7642\u5f8c\u306e\uff13\u5e74\u4ee5\u5185\u306b\u751f\u3058\u3066\u3057\u307e\u3046<\/span><\/strong>\u3053\u3068\u304c\u591a\u304f\u3066\u6cbb\u308a\u306b\u304f\u3044\u306e\u3067\uff0c\u65e9\u304f\u304b\u3089\u80a5\u6e80\u5bfe\u7b56\u3092\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059<\/li>\n<li>\u80a5\u6e80\u306b\u3088\u308b\uff12\u6b21\u5408\u4f75\u75c7\u306f\uff0c<span style=\"color: #000080;\"><strong>\u8102\u80aa\u809d\u3068\u809d\u969c\u5bb3\uff0c\u5fc3\u75be\u60a3\uff0c\u9ad8\u8102\u8cea\u8840\u6f3f<\/strong><\/span>\uff08\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\uff09\uff0c<span style=\"color: #000080;\"><strong>\u7cd6\u5c3f\u75c5\uff0c\u9ad8\u8840\u5727\uff0c\u52d5\u8108\u786c\u5316<\/strong><\/span>\u306a\u3069\u3067\u3059<\/li>\n<li>\u30e8\u30fc\u30ed\u30c3\u30d1\u304b\u3089\u306e\u9577\u671f\u7d4c\u904e\u89b3\u5bdf\u306e\u5831\u544a\u3067\u306f\u80a5\u6e80\u306b\u306a\u3063\u305f\u982d\u84cb\u54bd\u982d\u816b\u306e\u60a3\u8005\u3055\u3093\u306b\u5fc3\u81d3\u8840\u7ba1\u969c\u5bb3\u306e\u6b7b\u4ea1\u7387\u304c\u9ad8\u3044\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u80a5\u6e80\u306b\u3088\u3063\u3066\u904b\u52d5\u80fd\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u306f\u5f53\u7136\u3067\u3059\u3057\uff0c\u7b4b\u8089\u304c\u3064\u304d\u306b\u304f\u3044\u306e\u3067\u4f53\u529b\u4e0d\u8db3\u306b\u306a\u308a\u307e\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u3068\u3044\u3048\u3069\u3082\u7d50\u5c40\u306f\uff0c\u98df\u3079\u308b\u91cf\u304c\u591a\u304f\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6d88\u8cbb\u304c\u5c11\u306a\u3044\u306e\u304b\u3089\u80a5\u6e80\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u3067\uff0c\u30c0\u30a4\u30a8\u30c3\u30c8\u3092\u3057\u3066\u4f53\u3092\u52d5\u304b\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6d88\u8cbb\u3059\u308b\u3068\u3044\u3046\u80a5\u6e80\u5bfe\u7b56\u306e\u7b2c\uff11\u6b69\u304c\u3068\u3066\u3082\u5927\u5207\u3067\u3059<\/li>\n<li>\u7121\u610f\u8b58\u306e\u3046\u3061\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3066\u3044\u308b\u304b\u3089\uff0c\u610f\u8b58\u3057\u3066\u80a5\u6e80\u306b\u306a\u3089\u306a\u3044\u3088\u3046\u306b\u52aa\u529b\u306f\u3064\u3065\u3051\u3066\u304f\u3060\u3055\u3044<\/li>\n<li>\u3067\u3082\u80a5\u6e80\u306e\u6539\u5584\u306f\u3068\u3066\u3082\u96e3\u3057\u3044\u3067\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u3068\u4e0b\u5782\u4f53\u306b\u8a73\u3057\u3044\u5185\u5206\u6ccc\u5185\u79d1\u306e\u5148\u751f\u306b\u304d\u3073\u3057\u3044\u751f\u6d3b\u6307\u5c0e\u3092\u53d7\u3051\u307e\u3057\u3087\u3046<\/li>\n<li>\u3053\u306e\u80a5\u6e80\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u3088\u3044\u85ac\u306f\u306a\u3044\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u304c\uff0c\u85ac\u7269\u7642\u6cd5\u306f\u5185\u5206\u6ccc\u5185\u79d1\u306e\u5148\u751f\u306b\u805e\u3044\u3066\u4e0b\u3055\u3044<\/li>\n<li>2015\u5e749\u6708\u306bEuropean Commission\u304c\uff0c\u982d\u84cb\u54bd\u982d\u816b\u306b\u3088\u308b\u5236\u5fa1\u4e0d\u80fd\u306a\u3072\u3069\u3044\u80a5\u6e80\u306b\u5bfe\u3057\u3066\uff0c<span style=\"color: #000080;\"><strong>beloranib<\/strong><\/span>\u3068\u3044\u3046\u85ac\u5264\u3092\u627f\u8a8d\u3057\u307e\u3057\u305f\u304c\u65e5\u672c\u3067\u306f\u4f7f\u3048\u307e\u305b\u3093<\/li>\n<\/ul>\n<hr \/>\n<h4><strong><span style=\"color: #ff0000;\">\u30ca\u30c8\u30ea\u30a6\u30e0<\/span><\/strong>\u30d0\u30e9\u30f3\u30b9\u306e\u969c\u5bb3\u306b\u3064\u3044\u3066<\/h4>\n<ul>\n<li>\u8996\u5e8a\u4e0b\u90e8\u306e\u969c\u5bb3\u3067\u306f\uff0c<strong><span style=\"color: #ff0000;\">\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\uff08\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u5024\u304c130mEq\/l\u4ee5\u4e0b\uff09\u3084\u9ad8\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\uff08150mEq\/l\u4ee5\u4e0a\uff09<\/span><\/strong>\u306b\u306a\u3063\u305f\u308a\u3057\u307e\u3059<\/li>\n<li>\u8853\u5f8c\u306e\u6025\u6027\u671f\u3092\u904e\u304e\u308c\u3070\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u306e\u65b9\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u5c3f\u5d29\u75c7\u3067\u3082\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3059\u304c\uff0c\u5c3f\u5d29\u75c7\u3060\u3051\u3067\u306f\u5371\u967a\u306a\u30ca\u30c8\u30ea\u30a6\u30e0\u5024\u306b\u306f\u306a\u308a\u307e\u305b\u3093<\/li>\n<li>\u6cbb\u308a\u306b\u304f\u3044\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u3092\uff0c<strong><span style=\"color: #ff0000;\">CSW<\/span><\/strong> cerebral solt wasting syndrome <strong><span style=\"color: #ff0000;\">\u8133\u6027\u5869\u985e\u55aa\u5931\u75c7\u5019\u7fa4<\/span><\/strong><span style=\"color: #ff0000;\"><span style=\"color: #333333;\">\uff08\u8133\u6027\u5869\u55aa\u5931\u75c7\u5019\u7fa4\uff09<\/span><\/span>\u3068\u3044\u3044\u307e\u3059<\/li>\n<li>\u304b\u3064\u3066 <strong><span style=\"color: #ff0000;\">SIADH<\/span><\/strong> syndrome of inappropriate antidiuretic hormone secretion (\u6297\u5229\u5c3f\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u4e0d\u5168)\u3068\u3044\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u591a\u304f\u306e\u5834\u5408\u306f\u9055\u3044\u307e\u3059<\/li>\n<li>\u3044\u307e\u3067\u3082CSW\u3092SIADH\u3068\u8a3a\u65ad\u3059\u308b\u304a\u533b\u8005\u3055\u3093\u304c\u591a\u3044\u3067\u3059\uff0c\u7279\u306b\u8133\u5916\u79d1\u306e\u5148\u751f<\/li>\n<li>\u5869\uff08\u5869\u5316\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u306e\u4f53\u304b\u3089\u306e\u6392\u6cc4\u304c\u3046\u307e\u304f\u8abf\u6574\u3067\u304d\u306a\u3044\u306e\u3067\u3059<\/li>\n<li>\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u306e\u5834\u5408\u306f\u6bce\u65e5\u306e\u304a\u3057\u3063\u3053\u304b\u3089\u5869\u304c\u51fa\u3059\u304e\u307e\u3059<\/li>\n<li>\u5c3f\u91cf\u304c\u591a\u304f\u306a\u3063\u305f\u308a\uff0c\u7d30\u80de\u5916\u6db2\u304c\u5897\u3048\u305f\u308a\uff0cANP (ANH) \u3084BNP\u304c\u9ad8\u304f\u306a\u3063\u305f\u308a\u3057\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u7247\u5074\u3060\u3051\u306e\u8996\u5e8a\u4e0b\u90e8\u640d\u50b7\u3067\u306f\u3042\u307e\u308a\u8d77\u3053\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li><span style=\"color: #000080;\"><strong>\u4e21\u5074\u306e\u8996\u5e8a\u4e0b\u90e8\u306e\u5e95\u90e8\uff0c\u7b2c\uff13\u8133\u5ba4\u306e\u5e8a\u306e\u90e8\u5206\u306e\u640d\u50b7<\/strong><\/span>\u3067\u3088\u304f\u307f\u3089\u308c\u307e\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u3092\u304a\u304b\u3059\u816b\u760d\uff0c\u7279\u306b\u982d\u84cb\u54bd\u982d\u816b\uff0c\u661f\u7d30\u80de\u816b\uff0c\u80da\u7d30\u80de\u816b\u760d\u3067\u591a\u3044\u5f8c\u907a\u75c7\u3067\u3059<\/li>\n<li>\u8efd\u75c7\u306e\u3082\u306e\u306f\uff0c\u982d\u90e8\u5916\u50b7\u3084\u982d\u84cb\u9854\u9762\u9aa8\u5947\u5f62\uff08\u30af\u30eb\u30fc\u30be\u30f3\u75c5\u306a\u3069\uff09\u306e\u624b\u8853\u5f8c\u3067\u3082\u751f\u3058\u307e\u3059<\/li>\n<li>\u7b2c\uff13\u8133\u5ba4\u304c\u81a8\u3089\u3080\u9589\u585e\u6027\u6c34\u982d\u75c7\u3067\u3082\u7d4c\u9a13\u3057\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u4e0b\u5782\u4f53\u817a\u816b\uff08\u30d7\u30ed\u30af\u30c1\u30ce\u30fc\u30de\uff09\u3067\u3082\u898b\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u3082\u9ad8\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u3082\u3072\u3069\u304f\u306a\u308b\u3068<span style=\"color: #000080;\"><strong>\u610f\u8b58\u969c\u5bb3\u3084\u3051\u3044\u308c\u3093\u767a\u4f5c<\/strong><\/span>\u3092\u751f\u3058\u307e\u3059<\/li>\n<li>\u3072\u3069\u3044\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u5024\u306e\u3068\u304d\u610f\u8b58\u969c\u5bb3\u304c\u3042\u3063\u3066\u3082\u6025\u901f\u306b\u88dc\u6b63\u3057\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/li>\n<li>\u6025\u901f\u88dc\u6b63\u3092\u3059\u308b\u3068central pontine myelinolysis\u3068\u3044\u3063\u3066\u8133\u5e79\u90e8\u304c\u58ca\u308c\u3066\u3057\u307e\u3046\u6050\u308d\u3057\u3044\u7d50\u679c\u3092\u62db\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u6025\u6027\u671f\u3092\u3059\u304e\u308b\u3068\u6cbb\u308b\u3053\u3068\u3082\u591a\u3044\u306e\u3067\u3059\u304c\uff0c<span style=\"color: #000080;\"><strong>\u8996\u5e8a\u4e0b\u90e8\u306e\u969c\u5bb3\u304c\u5f37\u3044\u5834\u5408\u306b\u306f\u6cbb\u308a\u307e\u305b\u3093<\/strong><\/span><\/li>\n<li>\u5916\u6765\u3067\u5b9a\u671f\u7684\u306b\u8840\u6db2\u691c\u67fb\u3092\u3057\u3066\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u5024\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u3068\u3066\u3082\u5927\u5207\u3067\u3059<\/li>\n<li>\u30ca\u30c8\u30ea\u30a6\u30e0\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3066\u4f4e\u30ca\u30c8\u30ea\u30a6\u30e0\u8840\u6f3f\u306b\u306a\u308a\u3084\u3059\u3044\u5834\u5408\u306f\uff0c\u304a\u5869\u3092\u6bce\u65e5\u98f2\u307f\u307e\u3059\uff0c\u3053\u308c\u306f\u304a\u533b\u8005\u3055\u3093\u304c\u51e6\u65b9\u3057\u3066\u304f\u308c\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u9ad8\u71b1\u304c\u51fa\u305f\u308a\u3057\u3066\u5869\u5206\u304c\u6025\u901f\u306b\u5931<span class=\"setumei style1\">\u308f\u308c\u308b\u6642<\/span>\u306a\u3069\u3067\u30b7\u30e7\u30c3\u30af<\/strong><\/span>\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u5371\u967a\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u9ad8\u71b1\u3084\u75b2\u52b4\u3084\u98df\u4e8b\u3092\u629c\u304f\u3053\u3068\u3092\u907f\u3051\u306a\u3051\u308c\u3070\u884c\u3051\u307e\u305b\u3093\u3057\uff0c\u305d\u306e\u3088\u3046\u306a\u6642\u306f\u3068\u3066\u3082\u6ce8\u610f\u3057\u306a\u3044\u3068\u3044\u3051\u307e\u305b\u3093<\/li>\n<\/ul>\n<hr \/>\n<h4><span style=\"color: #000080;\"><strong><span style=\"color: #ff0000;\">\u9593\u8133\u75c7\u5019\u7fa4<\/span> (diencephalic syndrome)<\/strong>\u00a0<\/span><\/h4>\n<ul>\n<li>\u4f53\u91cd\u304c\u5897\u3048\u306a\u304f\u3066<span style=\"color: #000080;\"><strong><span class=\"setumei\">\u3072\u3069\u3044\u3084\u305b\uff08\u75e9\u305b\uff09<\/span><\/strong><\/span>\u304c\u3068\u304f\u3061\u3087\u3046\u3067\u3059\uff0cfailure of thrive\u3068\u3044\u308f\u308c\u3066\u4e08\u592b\u306b\u80b2\u3064\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u72b6\u614b\u3068\u8868\u73fe\u3055\u308c\u307e\u3059<\/li>\n<li>\u76ae\u4e0b\u8102\u80aa\u304c\u3064\u304b\u306a\u304f\u3066\u9aa8\u3068\u76ae\u3070\u304b\u308a\u306b\u306a\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong><span class=\"setumei\">\u8996\u5e8a\u4e0b\u90e8\u3092\u304a\u304b\u3059\u3044\u308d\u3044\u308d\u306a\u75c5\u6c17<\/span><\/strong><\/span>\u3067\u898b\u3089\u308c\u307e\u3059\u304c\uff0c\u7279\u306b\u661f\u7d30\u80de\u816b\u304c<span style=\"color: #000080;\"><strong>\uff11\u6b73\u524d\u5f8c\u306e<span class=\"setumei\">\u4e73\u5e7c\u5150\u306b\u767a\u751f<\/span><\/strong><\/span>\u3057\u3066\u3068\u3066\u3082\u5927\u304d\u304f\u306a\u3063\u305f\u6642\u306b\u3067\u307e\u3059<\/li>\n<li>\u98df\u3079\u308b\u3053\u3068\u304c\u5c11\u306a\u304f\u306a\u308b<span style=\"color: #000080;\"><strong>\u6442\u98df\u969c\u5bb3\u3082\u3042\u308b\u306e\u3067\u3059\u304c\uff0c\u3068\u306b\u304b\u304f\u98df\u3079\u3066\u3082\u592a\u3089\u306a\u3044<\/strong><\/span>\u306e\u3067\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u5614\u5410\u3092\u3059\u308b<\/strong><\/span>\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3067\u3059<\/li>\n<li>\u7a7a\u8179\u6642\u306e\u8840\u6db2\u306e\u4e2d\u306e<span style=\"color: #000080;\"><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3(GH)\u306e\u5024\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059<\/strong><\/span><\/li>\n<li>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u8ca0\u8377\u8a66\u9a13\u3067\u306f\u7570\u5e38\u306a\u53cd\u5fdc\u304c\u898b\u3089\u308c\u8996\u5e8a\u4e0b\u90e8\u304b\u3089\u306eGH-RH\u306e\u5206\u6ccc\u7570\u5e38\u3068\u8003\u3048\u3089\u308c\u307e\u3059<\/li>\n<li>\u78ba\u7acb\u3057\u305f\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3069\u3046\u3057\u3066\u3082\u98df\u3079\u3089\u308c\u306a\u3044\u6642\u306b\u306f\u4e2d\u5fc3\u9759\u8108\u6804\u990a\u3092\u3057\u3066\u3057\u306e\u304e\u307e\u3059<\/li>\n<li>\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u6cbb\u7642\u3067\u816b\u760d\u304c\u5c0f\u3055\u304f\u306a\u308b\u3068\u9593\u8133\u75c7\u5019\u7fa4\u3082\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u9593\u8133\u75c7\u5019\u7fa4\u304c\u6539\u5584\u3057\u305f\u5f8c\u306b\u306f\u9006\u306b\u80a5\u6e80\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u9577\u671f\u751f\u5b58\u3059\u308b\u306810\u6b73\u4ee5\u4e0b\u3067\u601d\u6625\u671f\u65e9\u767a\u75c7\uff08\uff12\u6b21\u6027\u5fb4\u304c\u65e9\u304f\u6765\u308b\uff09\u306b\u306a\u308b\u5b50\u4f9b\u304c\u591a\u3044\u3067\u3059<\/li>\n<\/ul>\n<hr \/>\n<h4><strong><span style=\"color: #ff0000;\">\u4f53\u6e29\u8abf\u7bc0\u969c\u5bb3\u00a0<\/span><\/strong><strong>(hypothermia\/hyperthermia)\u00a0<\/strong><\/h4>\n<ul>\n<li>\u4f53\u6e29\u8abf\u7bc0\u4e2d\u67a2\u306f\uff0c\u8996\u4ea4\u53c9\u306e\u76f4\u4e0a\u3042\u305f\u308a\u306e\u8996\u5e8a\u4e0b\u90e8\u306e\u524d\u90e8\u00a0<strong><span style=\"color: #000080;\">the preoptic area and anterior\u00a0hypothalamus\u00a0(PO\/AH)<\/span><\/strong><span style=\"color: #000000;\">\u306b\u3042\u308a\u307e\u3059<\/span><\/li>\n<li>\u6df1\u90e8\u8133\u6e29\u5ea6\u3068\u672b\u68a2\u6e29\u5ea6\u53d7\u5bb9\u5668\u304b\u3089\u306e\u4f53\u6e29\u60c5\u5831\u3092\u51e6\u7406\u3057\u3066\u3001\u81ea\u5f8b\u795e\u7d4c\u3092\u4ecb\u3057\u3066\u4f53\u6e29\u8abf\u7bc0\u3092\u3059\u308b\u6a5f\u80fd\u3092\u3082\u3063\u3066\u3044\u308b\u3068\u3053\u308d\u3067\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u304b\u3089\u306e\u4f53\u6e29\u306e\u8abf\u7bc0\u306f\uff0c1. \u9aa8\u683c\u7b4b\u306e\u4ee3\u8b1d\uff0c2. \u76ae\u819a\u306e\u5c0f\u52d5\u8108\u306e\u53ce\u7e2e\u80fd\uff0c3. \u6c57\u817a\u306e\u6a5f\u80fd\u3067\u5b9f\u884c\u3055\u308c\u307e\u3059<\/li>\n<li>\u982d\u84cb\u54bd\u982d\u816b\u306e\u5b50\u3069\u3082\u3067\u306e\u6cbb\u7642\u5f8c\u907a\u75c7\u3068\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u3053\u306e\u4e2d\u67a2\u306f\u7d42\u677f\u306e\u3059\u3050\u5916\u5074\u306b\u3042\u308b\u306e\u3067\uff0c\u982d\u84cb\u54bd\u982d\u816b\u304c\u7b2c\uff13\u8133\u5ba4\u306b\u3042\u3063\u305f\u308a\uff0c\u7d4c\u7d42\u677f\u6cd5\u3067\u624b\u8853\u3092\u884c\u3063\u305f\u6642\u306b\u51fa\u73fe\u3057\u3084\u3059\u3044\u3067\u3057\u3087\u3046<\/li>\n<li>\u30ac\u30f3\u30de\u30ca\u30a4\u30d5\u3084\u30b5\u30a4\u30d0\u30fc\u30ca\u30a4\u30d5\u6cbb\u7642\u306e\u5f8c\u3067\u3082\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u9ad8\u4f53\u6e29\u75c7\u3067\u3082\u306a\u304f\u3066\u4f4e\u4f53\u6e29\u75c7\u3067\u3082\u306a\u304f\u3066\uff0c\u4f53\u6e29\u304c\u5916\u6c17\u3068\u540c\u3058\u3088\u3046\u306b\u9ad8\u4f4e\u3057\u3066\u3057\u307e\u3046\u306e\u304c\u8996\u5e8a\u4e0b\u90e8\u6027\u306e\u4f53\u6e29\u8abf\u7bc0\u969c\u5bb3\u3067\u3059<\/li>\n<li>\u5909\u6e29\u52d5\u7269\u3068\u540c\u3058\u3088\u3046\u306b\u4f53\u6e29\u8abf\u7bc0\u304c\u3067\u304d\u306a\u3044\u5909\u52d5\u4f53\u6e29\u3068\u306a\u308a\u307e\u3059<\/li>\n<li>\u8996\u5e8a\u4e0b\u90e8\u306b\u3042\u308b\u4f53\u6e29\u3092\u8abf\u7bc0\u3059\u308b\u81ea\u5f8b\u795e\u7d4c\u306e\u50cd\u304d\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u3058\u307e\u3059<\/li>\n<li>\u9ad8\u5ea6\u306a\u3082\u306e\u306f\u3059\u3054\u304f\u73cd\u3057\u304f\u3066\u79c1\u81ea\u8eab\u30825\u4eba\u304f\u3089\u3044\u306e\u60a3\u8005\u3055\u3093\u3057\u304b\u898b\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u305b\u3093<\/li>\n<li>\u306a\u305c\u306a\u3089\uff0c\u4f53\u6e29\u8abf\u7bc0\u304c\u3067\u304d\u306a\u3044\u3088\u3046\u306a\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u306e\u60a3\u8005\u3055\u3093\u306f\u91cd\u7be4\u3067\u751f\u5b58\u3067\u304d\u306a\u3044\u3088\u3046\u306a\u75c5\u6c17\u304c\u591a\u3044\u306e\u3067\uff0c\u4f53\u6e29\u8abf\u7bc0\u304c\u3067\u304d\u306a\u3044\u307e\u307e\u9577\u671f\u751f\u5b58\u8005\u306b\u306a\u308b\u3053\u3068\u81ea\u4f53\u304c\u96e3\u3057\u3044\u304b\u3089\u3067\u3059<\/li>\n<li>\u4f4e\u4f53\u6e29\u306e\u65b9\u304c\u591a\u3044\u3067\u3059\uff0c\u5916\u6c17\u6e29\u304c\u4f4e\u3044\u306834\u2103\u304f\u3089\u3044\u306e\u4f53\u6e29\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u3066\u7720\u308a\u307e\u3059\u304b\u3089\u90e8\u5c4b\u3092\u6696\u3081\uff0c\u5916\u51fa\u6642\u306b\u306f\u30e0\u30af\u30e0\u30af\u306b\u7740\u8fbc\u3093\u3067\u5916\u3078\u51fa\u307e\u3059<\/li>\n<li>\u5916\u6c17\u6e29\u304c\u9ad8\u3044\u306838\u2103\u3092\u8d85\u3048\u308b\u9ad8\u71b1\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u304b\u3089\uff0c\u30a8\u30a2\u30b3\u30f3\u3068\u304b\u3067\u6e29\u5ea6\u8abf\u7bc0\u3057\u3066\u51b7\u3084\u3057\u307e\u3059<\/li>\n<li>\u65e5\u5e38\u751f\u6d3b\u304c\u3068\u3066\u3082\u4e0d\u4fbf\u3067\u5916\u51fa\u304c\u96e3\u3057\u304f\u306a\u308a\u307e\u3059<\/li>\n<li>\u6b8b\u5ff5\u306a\u304c\u3089\u85ac\u7269\u6cbb\u7642\u306f\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093<\/li>\n<\/ul>\n<h5><span style=\"color: #000080;\">\u4f53\u6e29\u8abf\u7bc0\u306e\u88cf\u6280<\/span><\/h5>\n<div style=\"padding-left: 30px;\">\uff18\u6b73\u306e\u5b50\u3069\u3082\u3067\uff0c\u4f53\u6e29\u304c\u5916\u6c17\u306b\u5408\u308f\u305b\u306638\u5ea6\u304f\u3089\u3044\u306b\u4e0a\u6607\u3057\u3066\u3057\u307e\u3046\u5b50\u304c\u3044\u307e\u3059\u3002\u7720\u3063\u3066\u3044\u3066\u3082\u767a\u71b1\u3057\u3066\u3057\u307e\u3046\u3057\uff0c\u5916\u6c17\u6e29\u304c30\u5ea6\u3092\u8d85\u3048\u308b\u3068\u767a\u71b1\uff0c\u6e7f\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u3068\u767a\u71b1\u3057\u307e\u3059\u3002\u305d\u306e\u5b50\u306f\uff0c\u5c0f\u5b66\u6821\u306b\u901a\u3046\u306e\u306b\uff0c<strong><span style=\"color: #ff0000;\">\u30a2\u30a4\u30b9\u30ea\u30e5\u30c3\u30af\uff08\u4fdd\u51b7\u6750\uff09\u3092\u80cc\u4e2d\u306b\u80cc\u8ca0\u3063\u3066\u884c\u304d\u307e\u3059\u3002<\/span><\/strong><span style=\"color: #000000;\">\u534a\u65e5\u3082\u3064\u306e\u3067\uff0c\u5b66\u6821\u3067\u304a\u663c\u306b\u4e00\u56de\u4ea4\u63db\u3057\u307e\u3059\u3002\u3053\u308c\u3067\u9ad8\u71b1\u3092\u51fa\u3055\u305a\u306b\u5143\u6c17\u306b\u5b66\u6821\u3078\u767b\u6821\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/div>\n<hr \/>\n<h4><strong><span style=\"color: #ff0000;\">\u767a\u6c57\u7570\u5e38\u00a0<\/span><\/strong><strong>(<\/strong><strong>dyshidrosis, hyperhidrosis)<\/strong><\/h4>\n<\/div>\n<ul>\n<li>\u767a\u6c57\u3068\u4f53\u6e29\u8abf\u7bc0\u306f\u540c\u3058\u4e2d\u67a2\u306b\u3042\u308a\u307e\u3059<\/li>\n<li><span style=\"color: #000080;\"><strong>\u8996\u5e8a\u4e0b\u90e8\u4f53\u6e29\u8abf\u7bc0\u4e2d\u67a2 hypothalamic thermoregulatory centre, thermostat center<\/strong><\/span> \u3068\u3044\u3046\u90e8\u4f4d\u304c\u816b\u760d\u3042\u308b\u3044\u306f\u624b\u8853\u3067\u640d\u50b7\u3055\u308c\u308b\u6642\u306b\u8d77\u3053\u308a\u307e\u3059<\/li>\n<li>\u4e21\u5074\u306e\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u3067\u306f\u76ee\u7acb\u3061\u307e\u305b\u3093\uff0c\u5de6\u53f3\u4e21\u534a\u8eab\u306e\u767a\u6c57\u7570\u5e38\u306f\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u4ee5\u5916\u306e\u30db\u30eb\u30e2\u30f3\u3084\u85ac\u306e\u526f\u4f5c\u7528\u306a\u3069\u3092\u8003\u3048\u307e\u3059<\/li>\n<li>\u6c57\u304c\u51fa\u306a\u3044\u3068\u3044\u3046\u3088\u308a\uff0c\u4ee5\u4e0a\u306b\u305f\u304f\u3055\u3093\u51fa\u308b\u73fe\u8c61\u306e\u65b9\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u7247\u5074\u306e\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u3067\uff0c\u53cd\u5bfe\u5074\u306e\u534a\u8eab\u3060\u3051\u306e\u767a\u6c57\u7570\u5e38\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<\/li>\n<li>\u6cbb\u7642\u65b9\u6cd5\u306f\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u304c\uff0c\u65e5\u5e38\u751f\u6d3b\u306e\u5927\u304d\u306a\u969c\u5bb3\u306b\u306f\u306a\u308a\u307e\u305b\u3093<\/li>\n<\/ul>\n<div class=\"setumei\">\n<hr \/>\n<h4><strong><span style=\"color: #ff0000;\"><span style=\"color: #000080;\">\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u88dc\u5145\u3068\u816b\u760d\u518d\u767a<\/span><\/span><\/strong><\/h4>\n<ul>\n<li>\u5b9f\u9a13\u7814\u7a76\u3067\u6210\u9577\u30db\u30eb\u30e2\u30f3(GH)\u306f\u7d30\u80de\u5206\u88c2\u3092\u4fc3\u3057\u305f\u308a\uff0c\u907a\u4f1d\u5b50\u306b\u969c\u5bb3\u3092\u53d7\u3051\u305f\u7d30\u80de\u304c\u3053\u308f\u308c\u308b(apoptosis)\u306e\u3092\u59a8\u3052\u307e\u3059<\/li>\n<li>\u305d\u306e\u3053\u3068\u304b\u3089\uff0c\u8133\u816b\u760d\u3092\u6cbb\u7642\u3057\u305f\u3042\u3068\u306b\uff0c\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068\u518d\u767a\u304c\u5897\u3048\u305f\u308a\uff0c\u65b0\u305f\u306a\u816b\u760d\u304c\u767a\u751f\u3059\u308b\u3068\u3044\u3046\u5371\u60e7\u304c\u3042\u308a\u307e\u3057\u305f<\/li>\n<li>\u3067\u3082\uff0c<span style=\"color: #000080;\"><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8133\u816b\u760d\u304c\u518d\u767a\u3057\u305f\u308a\u65b0\u305f\u306a\u816b\u760d\u304c\u3067\u304d\u305f\u308a\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3042\u308a\u307e\u305b\u3093\uff082019\u5e74\u6642\u70b9\u3067\u3082\uff09<\/strong><\/span><\/li>\n<li>\u3068\u304f\u306b<span style=\"color: #000080;\"><strong>\u982d\u84cb\u54bd\u982d\u816b<\/strong><\/span>\u3067\u306f\uff0c\u518d\u767a\u30ea\u30b9\u30af\u3068\u6210\u9577\u30db\u30eb\u30e2\u30f3\u6295\u4e0e\u306e\u95a2\u4fc2\u304c\u5168\u304f\u8a3c\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u306b\uff0c\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u6295\u4e0e\u3092\u9577\u671f\u306b\u308f\u305f\u3063\u3066\u6b62\u3081\u3089\u308c\u3066\u3057\u307e\u3046\u5b50\u3069\u3082\u304c\u591a\u3044\u3067\u3059<\/li>\n<li>\u982d\u84cb\u54bd\u982d\u816b\u306f\u305f\u304f\u3055\u3093\u306e\u5f8c\u907a\u75c7\u3092\u62b1\u3048\u3066\u751f\u304d\u3066\u3044\u304f\u5b50\u3069\u3082\u304c\u591a\u3044\u306e\u306b\uff0c<span style=\"color: #000080;\"><strong>\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u4f7f\u308f\u306a\u3044\u3068\u3055\u3089\u306b\u4f4e\u8eab\u9577\u3084\u80a5\u6e80\u3068\u3044\u3046\u969c\u5bb3 \u30cf\u30f3\u30c7\u30a3\u30ad\u30e3\u30c3\u30d7<\/strong><\/span>\u304c\u52a0\u308f\u3063\u3066\u3057\u307e\u3044\u307e\u3059<\/li>\n<li>\u3067\u3059\u304b\u3089\uff0c\u6210\u9577\u30db\u30eb\u30e2\u30f3\u304c\u8db3\u308a\u306a\u3044\u5b50\u4f9b\u305f\u3061\u306b\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u4f7f\u3046\u3053\u3068\u306b\u5fc3\u914d\u306f\u3044\u308a\u307e\u305b\u3093<\/li>\n<li>\u4ee3\u8868\u7684\u306a\uff14\u3064\u306e\u8ad6\u6587\u3092\u6319\u3052\u3066\u304a\u304d\u307e\u3059\uff08\u304b\u3064\u3066\u65ed\u5ddd\u533b\u5927\u5c0f\u5150\u79d1\u306e\u85e4\u679d\u5148\u751f\u306b\u6559\u3048\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\uff09<\/li>\n<\/ul>\n<p>1. Swerdlow AJ et al. Growth hormone treatment of children with brain tumors and risk of tumor recurrens. J Clin Endocrinol Metab 85: 4444-4449, 2000<br \/>\n\u30a4\u30ae\u30ea\u30b9\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002180\u4eba\u306e\u8133\u816b\u760d\u306e\u5b50\u4f9b\u305f\u3061\u306b\u6210\u9577\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u3002\u8133\u816b\u760d\u518d\u767a\u306e\u5371\u967a\u306f\u5897\u3055\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n2. Sklar CA et al. Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: A report from the childhood cancer survivors study. J Clin Endocrinol Metab 87: 3136-3141, 2002<br \/>\n\u7c73\u56fd\u304b\u3089\u306e\u5831\u544a\u3067\u3059\u3002172\u4eba\u306e\u8133\u816b\u760d\u60a3\u5150\u3092\u542b\u3080361\u4eba\u306e\u5c0f\u5150\u304c\u3093\u751f\u5b58\u8005\u306b\u6210\u9577\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u304c\u3055\u308c\u307e\u3057\u305f\u3002\u6210\u9577\u30db\u30eb\u30e2\u30f3\u306e\u6295\u4e0e\u306f\uff0c\u75c5\u6c17\u306e\u518d\u767a\u3084\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u304f\u3057\u306a\u3044\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u8133\u816b\u760d\u306e\u5b50\u4f9b\u3067\u65b0\u305f\u306a\u816b\u760d\u304c\u3088\u308a\u591a\u304f\u767a\u751f\u3059\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u3082\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n3. Ergun-Longmire B et al. Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor. J Clin Endocrinol Metab 91: 3494-3498, 2006<br \/>\n\u4e0a\u8a18\u3068\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u306e\u8ffd\u52a0\u5831\u544a\u3067\u3059\u3002\u3055\u3089\u306b\u7d4c\u904e\u89b3\u5bdf\u3092\u7d9a\u3051\u3066\u307e\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u4f7f\u7528\u3055\u308c\u305f\u5b50\u4f9b\u306b\u65b0\u305f\u306a\u56fa\u5f62\u816b\u760d\u306e\u767a\u751f\u7387\u304c\u5c11\u3057\u9ad8\u3044\u3068\u7d50\u8ad6\u3055\u308c\u307e\u3057\u305f\u3002\u3057\u304b\u3057\uff0c20\u4eba\u306e\u5b50\u4f9b\u306b\u767a\u751f\u3057\u305f\u816b\u760d\u306e\u5185\u306e\uff19\u4f8b\u306e2\u6b21\u816b\u760d\u306f\u9ac4\u819c\u816b\u3067\u3057\u305f\u3002\u3053\u306e\u4e2d\u306b\u306f\uff14\u4f8b\u306e\u9ac4\u82bd\u816b\u3092\u542b\u308011\u4f8b\u306e\u8133\u816b\u760d\u306e\u60a3\u5150\u304c\u3044\u307e\u3059\u300211\u4eba\u5168\u54e1\u304c\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u3066\uff18\u4eba\u3067\u306e2\u6b21\u816b\u760d\u306f\u9ac4\u819c\u816b\u3067\u3059\u3002\u653e\u5c04\u7dda\u8a98\u767a\u9ac4\u819c\u816b\u306f\u3068\u3066\u3082\u591a\u3044\u826f\u6027\u816b\u760d\u306a\u306e\u3067\uff0c\u3053\u306e\uff12\u6b21\u816b\u760d\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3068\u306f\u307b\u3068\u3093\u3069\u95a2\u4fc2\u306a\u3044\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002<br \/>\n4. Jenkins PJ, et al. Does growth horomene cause cancer? Clin Endocrinol 64: 115-121, 2006<br \/>\n\u3053\u308c\u306f\u7dcf\u8ad6\u3067\u3059\u3002\u6210\u9577\u30db\u30eb\u30e2\u30f3\u304c\u904e\u5270\u306b\u5206\u6ccc\u3055\u308c\u308b\u5148\u7aef\u5de8\u5927\u75c7\u306e\u60a3\u8005\u3055\u3093\u3067\u5927\u8178\u76f4\u8178\u764c\u306e\u767a\u751f\u7387\u304c\u9ad8\u3044\u305d\u3046\u3067\u3059\u3002\u3057\u304b\u3057\u6210\u9577\u30db\u30eb\u30e2\u30f3\u3092\u88dc\u5145\u3055\u308c\u305f\u5c0f\u5150\u3067\u306e\u764c\u306e\u767a\u751f\u30ea\u30b9\u30af\u306f\u9ad8\u304f\u306f\u306a\u308a\u307e\u305b\u3093\u3002<\/p>\n<hr \/>\n<h4>\u4ed6\u306b\u3082\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u3067\u306f\u4e0b\u8a18\u306e\u3088\u3046\u306a\u75c7\u72b6\u304c\u3042\u308a\u307e\u3059<\/h4>\n<ul>\n<li>\u6442\u98df\u969c\u5bb3\uff1a<span style=\"color: #ff0000;\"><strong>\u62d2\u98df\u3068\u904e\u98df<\/strong><\/span>\u3067\u3059<\/li>\n<li>\u4e73\u982d\u4f53\u3068\u95a2\u9023\u3059\u308b\u306e\u60c5\u52d5\u306e\u969c\u5bb3\uff1a<strong><span style=\"color: #ff0000;\">\u4e0d\u5b89\u3068\u6613\u6012\u6027<\/span><\/strong><\/li>\n<li>\u8133\u5f13\u67f1\uff0c\u4e73\u982d\u4f53\u3068\u95a2\u9023\u3059\u308b\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\uff1a<strong><span style=\"color: #ff0000;\">\u8a18\u9298\u529b\u969c\u5bb3<\/span><\/strong>\uff0c<strong><span style=\"color: #ff0000;\">\u77ed\u671f\u8a18\u61b6\u969c\u5bb3<\/span><\/strong><\/li>\n<li>\u904e\u8aa4\u816b\u306b\u304a\u3044\u3066\u307f\u3089\u308c\u308b\u767a\u4f5c\uff1a<strong><span style=\"color: #ff0000;\">\u7b11\u3044\u767a\u4f5c<\/span><\/strong>\u3001\u6ce3\u304d\u767a\u4f5c\uff0cgelastic seizure<\/li>\n<li>\u6027\u6b32\u306e\u6291\u5236\u3068\u4ea2\u9032<\/li>\n<li><span style=\"color: #ff0000;\"><strong>\u601d\u6625\u671f\u65e9\u767a<\/strong><span style=\"color: #333333;\"> precocious puberty<\/span><strong>\u00a0<span style=\"color: #333333;\">\u3068<\/span>\u601d\u6625\u671f\u9045\u767a\u75c7<\/strong><span style=\"color: #333333;\"> delayed onset of puberty<\/span><\/span><\/li>\n<li>\u7761\u7720\u969c\u5bb3\uff1a\u4e0d\u7720\u50be\u5411\u3067\u306f\u306a\u304f\u3066<strong><span style=\"color: #ff0000;\">\u50be\u7720\u50be\u5411<\/span><\/strong>\uff0c\u7761\u7720\u904e\u591a\uff0c\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3092\u3057\u307e\u3059<\/li>\n<li>growth without GH\uff1a<strong><span style=\"color: #ff0000;\">\u6210\u9577\u30db\u30eb\u30e2\u30f3\u304c\u306a\u304f\u3066\u3082\u8eab\u9577\u304c\u4f38\u3073\u308b<\/span><\/strong>\u3053\u3068<\/li>\n<\/ul>\n<hr \/>\n<p>\u307e\u305f\u8ffd\u52a0\u306e\u8a18\u8f09\u3092\u3057\u307e\u3059\u3002\u304a\u5f85\u3061\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a href=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/07\/photos\/sola142.png\"><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/07\/photos\/sola141.png\" alt=\"\" width=\"223\" height=\"341\" \/><img loading=\"lazy\" decoding=\"async\" src=\"\/sawamura\/blog\/wp-content\/uploads\/2012\/07\/photos\/sola142.png\" alt=\"\" width=\"233\" height=\"340\" \/><\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9593\u8133\u4e0b\u5782\u4f53\u4e0d\u5168\u3068\u3044\u3044\u307e\u3059 \u4e0b\u5782\u4f53\u817a\u816b\u3067\u306f\u8996\u5e8a\u4e0b\u90e8\u969c\u5bb3\u304c\u8d77\u3053\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u3042\u308a\u307e\u305b\u3093 \u4e0b\u5782\u4f53\u30db\u30eb\u30e2\u30f3\u304c\u8db3\u308a\u306a\u3044\u305f\u3081\u306b\u8d77\u3053\u308b\u969c\u5bb3\u306f\u3068\u3066\u3082\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u3053\u3067\u306f\u6bd4\u8f03\u7684\u3081\u305a\u3089\u3057\u3044\u3082\u306e\u3092\u66f8\u3044\u3066\u3044\u304d\u307e\u3059 \u7279\u306b\uff0c\u8996\u5e8a\u4e0b\u90e8\u306e\u969c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,4],"tags":[],"class_list":["post-101","post","type-post","status-publish","format-standard","hentry","category-pediattumor","category-braintumors"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/comments?post=101"}],"version-history":[{"count":26,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/101\/revisions"}],"predecessor-version":[{"id":12266,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/posts\/101\/revisions\/12266"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/media?parent=101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/categories?post=101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/sawamura\/blog\/wp-json\/wp\/v2\/tags?post=101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}