\u3000<\/p>\n\n\n\n
\u30fbAssociation of neighborhood built environments with physical activity and diabetes mellitus incidence.<\/em><\/strong><\/p>\n\n\n\n Kondo Y, Hamazaki K, Yamazaki C, Tsukui S, Yahagi N, Koyama H.<\/p>\n\n\n\n Tohoku J Exp Med. 2026 Apr 2 (in press)<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbAnalysis of amino acid residues affecting the transcriptional activity of nuclear factor Ya.<\/em><\/strong><\/p>\n\n\n\n Tao D, Takeuchi Y, Karkoutly S, Mehrazad Saber Z, Chen Y, Mendsaikhan T, Saikawa R, Aita Y, Murayama Y, Shikama A, Masuda Y, Yahagi N.<\/p>\n\n\n\n Mol Biol Res Commun 15:21-29, 2026.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbEvaluation of the effectiveness of feedback in a remote monitoring home-based training system for workers: a medium-scale randomized parallel-group controlled trial.<\/em><\/strong><\/p>\n\n\n\n Suzuki Y, Kawamoto H, Matsuda T, Suzuki H, Shimano H, Yahagi N.<\/p>\n\n\n\n Healthcare 13:2069, 2025.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbFoxO transcription factors regulate urea cycle through Ass1.<\/em><\/strong><\/p>\n\n\n\n Karkoutly S, Takeuchi Y, Mehrazad Saber Z, Ye C, Tao D, Aita Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N.<\/p>\n\n\n\n Biochem Biophys Res Commun 739:150594, 2024.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbGR-KLF15 pathway controls hepatic lipogenesis during fasting.<\/em><\/strong><\/p>\n\n\n\n Takeuchi Y, Murayama Y, Aita Y, Mehrazad Saber Z, Karkoutly S, Tao D, Katabami K, Ye C, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H, Yahagi N.<\/p>\n\n\n\n FEBS J 291:259-271, 2024.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbNew balance capability index as a screening tool for mild cognitive impairment.<\/em><\/strong><\/p>\n\n\n\n Suzuki Y, Tsubaki T, Nakaya K, Kondo G, Takeuchi Y, Aita Y, Murayama Y, Shikama A, Masuda Y, Suzuki H, Kawakami Y, Shimano H, Arai T, Hada Y, Yahagi N.<\/p>\n\n\n\n BMC Geriatr 23:74, 2023.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbExploratory analysis using machine learning of predictive factors for falls in persons with type 2 diabetes.<\/em><\/strong><\/p>\n\n\n\n Suzuki Y, Suzuki H, Ishikawa T, Yamada Y, Yatoh S, Sugano Y, Iwasaki H, Sekiya M, Yahagi N, Hada Y, Shimano H.<\/p>\n\n\n\n Sci Rep 12:11965, 2022.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbFoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin<\/em><\/strong><\/em><\/strong>.<\/p>\n\n\n\n Takeuchi Y, Yahagi N, Aita Y, Mehrazad Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H.<\/p>\n\n\n\n iScience 24:103446, 2021.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbHigh protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways<\/em><\/strong>.<\/em><\/strong><\/p>\n\n\n\n Mehrazad Saber Z, Takeuchi Y, Sawada Y, Aita Y, Ho MH, Karkoutly S, Tao D, Katabami K, Ye C, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Sugasawa T, Takekoshi K, Kawakami Y, Shimano H, Yahagi N.<\/p>\n\n\n\n Biochem Biophys Res Commun 582:35-42, 2021.<\/a><\/strong><\/p>\n\n\n\n \u3000 <\/p>\n\n\n\n \u30fbGenome-wide screening of upstream transcription factors using an expression library.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Takeuchi Y. <\/p>\n\n\n\n F1000Research 10:51, 2021.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbBudget impact analysis reveals walk-in fingertip HbA1c testing in community pharmacies could provide a significant long-term reduction in public expenditure.<\/em><\/strong><\/p>\n\n\n\n Shono A, Kondo M, Hoshi S, Okubo R, Yahagi N. <\/p>\n\n\n\n Res Social Adm Pharm S1551-7411(19)30787-9, 2020.<\/a><\/strong><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbGlucocorticoid receptor suppresses gene expression of Rev-erb\u03b1 (Nr1d1) through interaction with the CLOCK complex.<\/em><\/strong><\/p>\n\n\n\n Murayama Y, Yahagi N, Takeuchi Y, Aita Y, Mehrazad Saber Z, Wada N, Li E, Piao X,1 Sawada Y,1 Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Miyamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H. <\/p>\n\n\n\n FEBS Lett 593:423-432, 2019.<\/a><\/strong> <\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbCost-effectiveness of a new opportunistic screening strategy for walk-in fingertip HbA1c testing at community pharmacies in Japan.<\/em><\/strong><\/p>\n\n\n\n Shono A, Kondo M, Hoshi S, Okubo R, Yahagi N. <\/p>\n\n\n\n Diabetes Care 41:1218-1226, 2018.<\/strong><\/a> <\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbMalondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes.<\/em><\/strong><\/p>\n\n\n\n Furukawa S, Suzuki H, Fujihara K, Kobayashi K, Iwasaki H, Sugano Y, Yatoh S, Sekiya M, Yahagi N, Shimano H.<\/p>\n\n\n\n Diabetes Res Clin Pract 141:237-243, 2018.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbA candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.<\/em><\/strong><\/p>\n\n\n\n Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.<\/p>\n\n\n\n FEBS Lett 592:422-433, 2018.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbEffect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.<\/em><\/strong><\/p>\n\n\n\n Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N.<\/p>\n\n\n\n Biochem Biophys Res Commun 493:40-45, 2017.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbA key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.<\/em><\/strong><\/p>\n\n\n\n Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H.<\/p>\n\n\n\n FEBS Lett 591:965-978, 2017.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbKLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting.<\/em><\/strong><\/p>\n\n\n\n Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H.<\/p>\n\n\n\n Cell Reports 16:2373-86, 2016.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbIdentification of human ELOVL5 enhancer regions controlled by SREBP.<\/em><\/strong><\/p>\n\n\n\n Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N.<\/p>\n\n\n\n Biochem Biophys Res Commun 465:857-63, 2015.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbGlycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.<\/em><\/strong><\/p>\n\n\n\n Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H.<\/p>\n\n\n\n Nat Commun 4:2316, 2013.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbPolyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.<\/em><\/strong><\/p>\n\n\n\n Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga JI, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H.<\/p>\n\n\n\n J Biol Chem 285:11681-91, 2010.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbHormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep(ob)(\/)(ob) mice.<\/em><\/strong><\/p>\n\n\n\n Sekiya M, Yahagi N, Tamura Y, Okazaki H, Igarashi M, Ohta K, Takanashi M, Kumagai M, Takase S, Nishi M, Takeuchi Y, Izumida Y, Kubota M, Ohashi K, Iizuka Y, Yagyu H, Gotoda T, Nagai R, Shimano H, Yamada N, Kadowaki T, Ishibashi S, Osuga JI.<\/p>\n\n\n\n Biochem Biophys Res Commun 387:511-5, 2009.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbCyclin-dependent kinase inhibitor, p21WAF1\/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity and insulin resistance.<\/em><\/strong><\/p>\n\n\n\n Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H.<\/p>\n\n\n\n J Biol Chem 283:21220-9, 2008.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbIn vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.<\/em><\/strong><\/p>\n\n\n\n Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI, Shimano H.<\/p>\n\n\n\n Biochem Biophys Res Commun 363:329-35, 2007.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbSterol regulatory element-binding protein (SREBP) -1-independent regulation of lipogenic gene expression in adipocytes.<\/em><\/strong><\/p>\n\n\n\n Sekiya M, Yahagi N, Matsuzaka T, Takeuchi Y, Nakagawa Y, Takahashi H, Okazaki H, Iizuka Y, Ohashi K, Gotoda T, Ishibashi S, Nagai R, Yamazaki T, Kadowaki T, Yamada N, Osuga JI, Shimano H.<\/p>\n\n\n\n J Lipid Res 48:1581-91, 2007.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbCrucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.<\/em><\/strong><\/p>\n\n\n\n Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga JI, Yamada N.<\/p>\n\n\n\n Nat Med 13:1193-1202, 2007.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbTFE3, a novel transcription factor for hepatic IRS-2 and insulin signals, ameliorates diabetes.<\/em><\/strong><\/p>\n\n\n\n Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.<\/p>\n\n\n\n Nat Med 12:107-13, 2006.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbHigh mobility group protein-B1 (HMGB1) interacts with sterol regulatory element-binding proteins (SREBPs) to enhance their DNA binding.<\/em><\/strong><\/p>\n\n\n\n Najima Y, Yahagi N, Takeuchi Y, Matsuzaka T, Sekiya M, Nakagawa Y, Amemiya-Kudo M, Okazaki H, Okazaki S, Tamura Y, Iizuka Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Yamada N, Osuga JI, Shimano H.<\/p>\n\n\n\n J Biol Chem 280:27523-32, 2005.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbCoordinate activation of lipogenic enzymes in hepatocellular carcinoma.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Shimano H, Hasegawa K, Ohashi K, Matsuzaka T, Najima Y, Sekiya M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Nagai R, Ishibashi S, Kadowaki T, Makuuchi M, Ohnishi S, Osuga JI, Yamada N.<\/p>\n\n\n\n Eur J Cancer 41:1316-22, 2005.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbSREBPs suppress IRS-2-mediated insulin signalling in the liver.<\/em><\/strong><\/p>\n\n\n\n Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N.<\/p>\n\n\n\n Nat Cell Biol 6:351-7, 2004.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbInsulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.<\/em><\/strong><\/p>\n\n\n\n Matsuzaka T, Shimano H, Yahagi N, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Tomita S, Sekiya M, Hasty A, Nakagawa Y, Sone H, Toyoshima H, Ishibashi S, Osuga J, Yamada N.<\/p>\n\n\n\n Diabetes 53:560-9, 2004.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbp53 involvement in the pathogenesis of fatty liver disease.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Shimano H, Matsuzaka T, Sekiya M, Najima Y, Okazaki S, Okazaki H, Tamura Y, Iizuka Y, Inoue N, Nakagawa Y, Takeuchi Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Osuga JI, Yamada N.<\/p>\n\n\n\n J Biol Chem 279:20571-5, 2004.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbp53 activation in adipocytes of obese mice.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Shimano H, Matsuzaka T, Najima Y, Sekiya M, Nakagawa Y, Ide T, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Gotoda T, Nagai R, Kimura S, Ishibashi S, Osuga JI, Yamada N.<\/p>\n\n\n\n J Biol Chem 278:25395-400, 2003.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbPolyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.<\/em><\/strong><\/p>\n\n\n\n Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.<\/p>\n\n\n\n Hepatology 38:1529-39, 2003.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbAbsence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)\/Lep(ob) mice.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.<\/p>\n\n\n\n J Biol Chem 277:19353-7, 2002.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbCloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.<\/em><\/strong><\/p>\n\n\n\n Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S, Yamada N.<\/p>\n\n\n\n J Lipid Res 43:911-20, 2002.<\/strong><\/a><\/p>\n\n\n\n \u3000<\/p>\n\n\n\n \u30fbA crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.<\/em><\/strong><\/p>\n\n\n\n Yahagi N, Shimano H, Hasty A H, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.<\/p>\n\n\n\n