{"id":238,"date":"2021-11-17T01:17:08","date_gmt":"2021-11-16T16:17:08","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/nutrigenomics\/%e7%ad%91%e6%b3%a2%e5%a4%a7%e5%ad%a6%e5%8c%bb%e5%ad%a6%e5%8c%bb%e7%99%82%e7%b3%bb-%e3%83%8b%e3%83%a5%e3%83%bc%e3%83%88%e3%83%aa%e3%82%b2%e3%83%8e%e3%83%9f%e3%82%af%e3%82%b9%e3%83%aa%e3%82%b5%e3%83%bc\/"},"modified":"2025-09-21T11:01:29","modified_gmt":"2025-09-21T02:01:29","slug":"ngrg_en","status":"publish","type":"page","link":"https:\/\/plaza.umin.ac.jp\/nutrigenomics\/en\/","title":{"rendered":"Nutrigenomics Research Group"},"content":{"rendered":"\n

Introduction of the laboratory<\/strong><\/h2>\n\n\n\n

Our laboratory (Nutrigenomics Research Group) is based on the Laboratory of Molecular Physiology on Energy Metabolism<\/a>, which was established in the Graduate School of Medicine at the University of Tokyo from 2008 to 2011. Since then, we have been working as a research group spanning the University of Tsukuba, the University of Tokyo and Jichi Medical University.

Our scope is to elucidate how nutritional signals regulate gene expression and adapt individuals to their nutritional environment, using original methods to directly analyze the interaction between nutritional signals and the genome<\/em><\/strong> in animal bodies. (Group head: Naoya Yahagi)<\/p>\n\n\n\n

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What’s New<\/strong><\/h2>\n\n\n\n

November 17, 2021<\/strong><\/em>
Published in iScience<\/em><\/strong><\/a><\/p>\n\n\n\n

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We elucidated the mechanism how insulin transcriptionally controls the flow between fat, glucose and protein.
“FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin.” iScience, 2021.<\/a>
Click here for more information<\/a><\/p>\n<\/div><\/div>\n\n\n\n

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March 15, 2021 <\/em><\/strong>
Experimental Medicine Extra Issue “<\/b><\/em>Obesity research in the era of precision medicine<\/a><\/em>“<\/strong><\/p>\n\n\n\n

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Experimental Medicine Extra Issue “Obesity research in the era of precision medicine” was published on March 15.
Click here for more information<\/a> <\/p>

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August 01, 2019<\/em><\/strong>
Monthly “The CELL” Issue<\/a><\/em><\/strong><\/p>\n\n\n\n

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In the August 2019 issue of the monthly “The CELL”, a special feature entitled “Starvation Response and Energy Metabolism Control as Seen from Organelles” was published.
Click here for more information<\/a> <\/p>

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September 05, 2016<\/em><\/strong>
Experimental Medicine Extra Issue “Nutritional signaling, a new leading player in gene control<\/a>“<\/em><\/strong><\/p>\n\n\n\n

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Experimental Medicine Extra Issue “Nutritional signaling – A new leading player in gene control – Transcriptional regulation by sugars, lipids, and amino acids – Nutrigenomics connecting homeostasis mechanisms and diseases” was published on September 5.
Click here for more information<\/a> <\/p>\n\n\n\n

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August 18, 2016<\/em><\/strong>
Published in Cell Reports<\/a><\/em><\/strong><\/p>\n\n\n\n

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We elucidated the mechanism of fasting and feeding responses of the SREBP-1 gene.
“KLF15 enables rapid switching between between lipogenesis and gluconeogenesiss during fasting.” Cell Reports, 2016.<\/a>
Click here for more information<\/a> <\/p>\n\n\n\n

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Introduction of the laboratory Our labor … <\/p>\n","protected":false},"author":1,"featured_media":368,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-238","page","type-page","status-publish","has-post-thumbnail","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t