注意： これらの研究は一般的な日本人の体内濃度を調査する目的で実施されたものです。母乳中の化学物質を測定していますが、乳児への危険性を示すような事例ではありません。母乳育児が優れていることは多くの研究で示されており、化学物質が含まれていることで過度に避ける必要はないと考えております。

Lyu Z, Harada KH, Kim S, Fujitani T, Cao Y, Hitomi T, Fujii Y, Kho Y, Choi K. Exposure to phthalate esters in Japanese females in Kyoto, Japan from 1993 to 2016: Temporal trends and associated health risks. Environ Int 2022;165:107288.

Fujii Y, Harada KH, Ito Y, Yoshitake M, Matsunobu C, Kato Y, Ohta C, Koga N, Kimura O, Endo T, Koizumi A, Haraguchi K. Profiles and determinants of dicofol, endosulfans, mirex, and toxaphenes in breast milk samples from 10 prefectures in Japan. Chemosphere 2022:137002.

Fujitani T, Fujii Y, Lyu Z, Harada Sassa M, Harada KH. Urinary equol levels are positively associated with urinary estradiol excretion in women. Sci Rep 2021;11:19532.

Lyu Z, Soleman SR, Fujitani T, Fujii Y, Mahmoud MAM, Harada KH. Absence of Detectable Radionuclides in Breast Milk in Sendai, Japan in 2012 Even by High-Sensitivity Determination: Estimated Dose among Infants after the Fukushima Nuclear Disaster. Int J Environ Res Public Health 2021;18:5825.

Harada KH, Fujii Y, Zhu J, Zheng B, Cao Y, Hitomi T. Analysis of Perfluorooctanesulfonate Isomers and Other Perfluorinated Alkyl Acids in Serum by In-Port Arylation Gas Chromatography Negative Chemical Ionization窶溺ass Spectrometry. Environ. Sci. Technol. Lett. 2020;7:259-65.

Lyu Z, Harada Sassa M, Fujitani T, Harada KH. Serological Tests for SARS-CoV-2 Coronavirus by Commercially Available Point-of-Care and Laboratory Diagnostics in Pre-COVID-19 Samples in Japan. Diseases 2020;8:36.

Soleman SR, Fujitani T, Fujii Y, Harada KH. Levels of Octachlorostyrene in Mothers' Milk and Potential Exposure Among Infants in Sendai City, Japan 2012. Int J Environ Res Public Health 2020;17:3064.

Fujii Y, Tuda H, Kato Y, Kimura O, Endo T, Harada KH, Koizumi A, Haraguchi K. Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean. Environ Pollut 2019;247:312-8.

Fujii Y, Kato Y, Kozai M, Matsuishi T, Harada KH, Koizumi A, Kimura O, Endo T, Haraguchi K. Different profiles of naturally produced and anthropogenic organohalogens in the livers of cetaceans from the Sea of Japan and the North Pacific Ocean. Mar Pollut Bull 2018;136:230-42.

Fujii Y, Kato Y, Masuda N, Harada KH, Koizumi A, Haraguchi K. Contamination trends and factors affecting the transfer of hexabromocyclododecane diastereomers, tetrabromobisphenol A, and 2,4,6-tribromophenol to breast milk in Japan. Environ Pollut 2018;237:936-43.

Fujii Y, Kato Y, Sakamoto K, Matsuishi T, Harada KH, Koizumi A, Kimura O, Endo T, Haraguchi K. Tissue-specific bioaccumulation of long-chain perfluorinated carboxylic acids and halogenated methylbipyrroles in Dall's porpoises (Phocoenoides dalli) and harbor porpoises (Phocoena phocoena) stranded in northern Japan. Sci Total Environ 2018;616-617:554-63.

Cao Y, Harada KH, Hitomi T, Niisoe T, Wang P, Shi Y, Yang HR, Takasuga T, Koizumi A. Lactational exposure to short-chain chlorinated paraffins in China, Korea, and Japan. Chemosphere 2017;173:43-8.

Fujii Y, Harada KH, Haraguchi K, Koizumi A. Long-term trends in dietary intake of perfluoroalkyl carboxylic acids in relation to their serum concentration in two regions in Japan from 1979 to 2011. Chemosphere 2017;176:165-74.

Cao Y, Kobayashi H, Morimoto T, Kabata R, Harada KH, Koizumi A. Frequency of RNF213 p.R4810K, a susceptibility variant for moyamoya disease, and health characteristics of carriers in the Japanese population. Environ Health Prev Med 2016;21:387-90.

Harada KH, Tanaka K, Sakamoto H, Imanaka M, Niisoe T, Hitomi T, Kobayashi H, Okuda H, Inoue S, Kusakawa K, Oshima M, Watanabe K, Yasojima M, Takasuga T, Koizumi A. Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. PLoS One 2016;11:e0146335.

Haraguchi K, Ito Y, Takagi M, Fujii Y, Harada KH, Koizumi A. Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples. Environ Int 2016;97:155-62.

Kabata R, Nanayakkara S, Senevirathna S, Harada KH, Chandrajith R, Hitomi T, Abeysekera T, Takasuga T, Koizumi A. Neonicotinoid concentrations in urine from chronic kidney disease patients in the North Central Region of Sri Lanka. J Occup Health 2016;58:128-33.

Fujii Y, Niisoe T, Harada KH, Uemoto S, Ogura Y, Takenaka K, Koizumi A. Toxicokinetics of perfluoroalkyl carboxylates with different carbon chain lengths in mice and humans. J Occup Health 2015;57:1-12.

Ueyama J, Harada KH, Koizumi A, Sugiura Y, Kondo T, Saito I, Kamijima M. Temporal Levels of Urinary Neonicotinoid and Dialkylphosphate Concentrations in Japanese Women Between 1994 and 2011. Environ Sci Technol 2015;49:14522-8.

Fujii Y, Harada KH, Hitomi T, Kobayashi H, Koizumi A, Haraguchi K. Temporal trend and age-dependent serum concentration of phenolic organohalogen contaminants in Japanese men during 1989-2010. Environ Pollut 2014;185:228-33.

Fujii Y, Nishimura E, Kato Y, Harada KH, Koizumi A, Haraguchi K. Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan. Environ Int 2014;63:19-25.

Harada KH, Niisoe T, Imanaka M, Takahashi T, Amako K, Fujii Y, Kanameishi M, Ohse K, Nakai Y, Nishikawa T, Saito Y, Sakamoto H, Ueyama K, Hisaki K, Ohara E, Inoue T, Yamamoto K, Matsuoka Y, Ohata H, Toshima K, Okada A, Sato H, Kuwamori T, Tani H, Suzuki R, Kashikura M, Nezu M, Miyachi Y, Arai F, Kuwamori M, Harada S, Ohmori A, Ishikawa H, Koizumi A. Radiation dose rates now and in the future for residents neighboring restricted areas of the Fukushima Daiichi Nuclear Power Plant. Proc Natl Acad Sci U S A 2014;111:E914-23.

Yan J, Inoue K, Asakawa A, Harada KH, Watanabe T, Hachiya N, Koizumi A. Methylmercury monitoring study in Karakuwacho peninsula area in Japan. Bull Environ Contam Toxicol 2014;93:36-41.

Harada KH, Fujii Y, Adachi A, Tsukidate A, Asai F, Koizumi A. Dietary Intake of Radiocesium in Adult Residents in Fukushima Prefecture and Neighboring Regions after the Fukushima Nuclear Power Plant Accident: 24-h Food-Duplicate Survey in December 2011. Environ Sci Technol 2013;47:2520-6.

Liu W, Tanabe M, Harada KH, Koizumi A. Levels of urinary isoflavones and lignan polyphenols in Japanese women. Environ Health Prev Med 2013;18:394-400.

Liu W, Hitomi T, Kobayashi H, Harada KH, Koizumi A. Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian Populations. Neurol Med Chir (Tokyo) 2012;52:299-303.

Matsubara F, Haraguchi K, Harada K, Koizumi A. Screening for antibodies to human T-cell leukemia virus type I in Japanese breast milk. Biol Pharm Bull 2012;35:773-6.

Fujii Y, Harada KH, Koizumi A. Analysis of perfluoroalkyl carboxylic acids in composite dietary samples by gas chromatography/mass spectrometry with electron capture negative ionization. Environ Sci Technol 2012;46:11235-42.

Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K. Comparative survey of levels of chlorinated cyclodiene pesticides in breast milk from some cities of China, Korea and Japan. Chemosphere 2012;89:452-7.

Fujii Y, Ito Y, Harada KH, Hitomi T, Koizumi A, Haraguchi K. Regional variation and possible sources of brominated contaminants in breast milk from Japan. Environ Pollut 2012;162:269-74.

Koizumi A, Harada KH, Niisoe T, Adachi A, Fujii Y, Hitomi T, Kobayashi H, Wada Y, Watanabe T, Ishikawa H. Preliminary assessment of ecological exposure of adult residents in Fukushima Prefecture to radioactive cesium through ingestion and inhalation. Environ Health Prev Med 2012;17:292-8.

Harada KH, Takasuga T, Hitomi T, Wang P, Matsukami H, Koizumi A. Dietary exposure to short-chain chlorinated paraffins has increased in Beijing, China. Environ Sci Technol 2011;45:7019-27.

Harada KH, Hitomi T, Niisoe T, Takenaka K, Kamiyama S, Watanabe T, Moon CS, Yang HR, Hung NN, Koizumi A. Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam. Environ Int 2011;37:1183-9.

Fujii Y, Haraguchi K, Harada KH, Hitomi T, Inoue K, Itoh Y, Watanabe T, Takenaka K, Uehara S, Yang HR, Kim MY, Moon CS, Kim HS, Wang P, Liu A, Hung NN, Koizumi A. Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan. Chemosphere 2011;82:25-31.

Desalegn B, Takasuga T, Harada KH, Hitomi T, Fujii Y, Yang HR, Wang P, Senevirathna S, Koizumi A. Historical trends in human dietary intakes of endosulfan and toxaphene in China, Korea and Japan. Chemosphere 2011;83:1398-405.

Niisoe T et al. A global transport model of lead in the atmosphere
Atmos Environ. Accepted 7 Jan; 44(14): 1806-1814, 2010 doi: 10.1016/j.atmosenv.2010.01.001
大気中の鉛が東アジアでは中国から越境してくるものが多いこと、そして空気を介して我々の血液中に蓄積していることをシミュレーションしました。

Harada KH et al. Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008
Chemosphere. Accepted 18 Jan, 79(3):314-319, 2010 doi: 10.1016/j.chemosphere.2010.01.027
近年、残留性有機汚染物質として注目されているペルフルオロオクタン酸、ペルフルオロオクタンスルホン酸の血清中濃度を、日本、韓国、ベトナムの成人女性について調査しました。米国3M社による製造廃止2002年以降、ペルフルオロオクタンスルホン酸は大きく減少してきていますが、ペルフルオロオクタン酸は変化は見られませんでした。また韓国ではペルフルオロオクタン酸がまだ増加していました。

Haraguchi K et al. Levels and regional trend of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrated POPs signatures unique to individual countries
Environ Int. Accepted 8 June, 35(7):1072-1079, 2009 doi: 10.1016/j.envint.2009.06.003
日本、韓国、中国、ベトナムの授乳婦の母乳中の残留性有機汚染物質を調査しました。日本ではかつてに比べて、POPsは減少してきましたが、中国、ベトナムではDDTやヘキサクロロベンゼンなどの汚染が大きく、近年までDDTなどを使用してきたことが原因ではないかと考えられています。

Koizumi A et al. Paradoxical Increases in Serum Levels of Highly Chlorinated PCBs in Aged Women in Clear Contrast to Robust Decreases in Dietary Intakes from 1980 to 2003 in Japan
Environ. Health Prev Med. Accepted 26 Apr, available online 28 May, 14(4):235-246, 2009 doi: 10.1007/s12199-009-0089-6
日本で1970年代に使用禁止になったPCB類を食事、血液で調査しました。1980年代、90年代、2000年代で比較したところ、食事中濃度は半分以下になってきましたが、まだ血液中濃度は変化は少ない結果となりました。また蓄積性の高い高塩素化PCBの割合はむしろ増加し、影響が長く続いていることが示唆されました。

Karrman, A., Harada, K.H., Inoue, K., Takasuga, T., Ohi, E., Koizumi, A., 2009. Analysis of Perfluorochemicals (PFCs) in diet duplicates and serum from Japan.
Environ Int. 35(4): 712-717, 2009 doi:10.1016/j.envint.2009.01.010
有機フッ素化合物ペルフルオロオクタン酸、ペルフルオロオクタンスルホン酸の食事中濃度を調査しました。いずれも成人で100ng程度を摂取していることが分かりました。しかし、汚染が強いと考えられる大阪と比較的汚染が少ない東北地方の間で差は少なく、大阪では他の摂取源が考えられました。

Harada, K., Koizumi, A., Saito, N., Inoue, K., Yoshinaga, T., Date, C., Fujii, S., Hachiya, N., Hirosawa, I., Koda, S., Kusaka, Y., Murata, K., Omae, K., Shimbo, S., Takenaka, K., Takeshita, T., Todoriki, H., Wada, Y., Watanabe, T., Ikeda, M., 2007. Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. Chemosphere 66, 293-301.
試料バンクに保存されている1980年代、90年代の血清を用いて、有機フッ素化合物の変遷を調査しました。1990年代にはペルフルオロオクタンスルホン酸は一定になりましたが、ペルフルオロオクタン酸はこの20年間で4倍以上の増加を見せており、フッ素樹脂の製造量の増加に近いトレンドを見せました。

Inoue, K., Harada, K., Takenaka, K., Uehara, S., Kono, M., Shimizu, T., Takasuga, T., Senthilkumar, K., Yamashita, F., Koizumi, A., 2006. Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers. Environ Health Perspect 114, 1179-1185.
難燃剤に使われるポリ臭素化ジフェニルエーテルについて母乳と血清を調査しました。血液と母乳で見られる化学物質は大きく異なり、10臭素化体DeBDEは血液ではもっとも多いのですが、母乳には少ないことが分かりました。このような血液から母乳に分泌されるパターンを明らかにし、乳児に入りやすい物質を予測することが期待されます。

Eslami, B., Koizumi, A., Ohta, S., Inoue, K., Aozasa, O., Harada, K., Yoshinaga, T., Date, C., Fujii, S., Fujimine, Y., Hachiya, N., Hirosawa, I., Koda, S., Kusaka, Y., Murata, K., Nakatsuka, H., Omae, K., Saito, N., Shimbo, S., Takenaka, K., Takeshita, T., Todoriki, H., Wada, Y., Watanabe, T., Ikeda, M., 2006. Large-scale evaluation of the current level of polybrominated diphenyl ethers (PBDEs) in breast milk from 13 regions of Japan. Chemosphere 63, 554-561.

Koizumi, A., Yoshinaga, T., Harada, K., Inoue, K., Morikawa, A., Muroi, J., Inoue, S., Eslami, B., Fujii, S., Fujimine, Y., Hachiya, N., Koda, S., Kusaka, Y., Murata, K., Nakatsuka, H., Omae, K., Saito, N., Shimbo, S., Takenaka, K., Takeshita, T., Todoriki, H., Wada, Y., Watanabe, T., Ikeda, M., 2005. Assessment of human exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in Japan using archived samples from the early 1980s and mid-1990s. Environ Res 99, 31-39.

Wada, Y., Koizumi, A., Yoshinaga, T., Harada, K., Inoue, K., Morikawa, A., Muroi, J., Inoue, S., Eslami, B., Hirosawa, I., Hirosawa, A., Fujii, S., Fujimine, Y., Hachiya, N., Koda, S., Kusaka, Y., Murata, K., Nakatsuka, H., Omae, K., Saito, N., Shimbo, S., Takenaka, K., Takeshita, T., Todoriki, H., Watanabe, T., Ikeda, M., 2005. Secular trends and geographical variations in the dietary intake of polybrominated diphenyl ethers (PBDEs) using archived samples from the early 1980s and mid 1990s in Japan. J Occup Health 47, 236-241.

Harada, K., Saito, N., Inoue, K., Yoshinaga, T., Watanabe, T., Sasaki, S., Kamiyama, S., Koizumi, A., 2004. The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years. J Occup Health 46, 141-147.

ヒトの血清における炭素・窒素安定同位体比およびメチル水銀濃度と魚介類摂取量との関係
中下留美子、鈴木彌生子、一宮孝博、原田浩二、蜂谷紀之、小泉昭夫、伊永隆史

Natural persistent organohalogens in breast milk from Japan.
Haraguchi K, Hisamichi Y, Nishimura E, Endo T

血液少量化分析法による健常人PCB主要異性体の分析
　平井哲也、藤峰慶徳、渡部俊吉、小泉昭夫

保存血液・食事試料を用いた1979年から1997年のメチル水銀曝露量の推定
蜂谷紀之、中野篤浩、安武章、小泉昭夫

難分解性化学物質を対象とした生体試料バンクの創設に関する研究
吉永侃夫、原田浩二、井上佳代子、森川亜紀子、Eslami Bita、井上純子、湯木知史、ヒト生体試料バンク研究班グループ、小泉昭夫

難分解性化学物質を対象とした生体試料バンクの創設に関する研究
吉永侃夫、原田浩二、井上佳代子、森川亜紀子、Eslami Bita、井上純子、新保慎一郎、池田正之、小泉昭夫

Establishment of the public sample bank to monitor a long-term trend of human exposure to persistent organic pollutants (Pops).
Kayoko Inoue, Koizumi Akio, Yoshinaga Takeo, Harada Kouji, Saito Norimitu.

A long-term trend of serum levels of perfluorooctane sulfonate (PFOS) and　perfluorooctanoate (PFOA) in Japanese.
Kouji Harada, Koizumi Akio, Yoshinaga Takeo, Inoue Kayoko, Saito Norimitu.