{"id":1272,"date":"2026-11-09T14:55:40","date_gmt":"2026-11-09T14:55:40","guid":{"rendered":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/?p=1272"},"modified":"2026-11-09T14:56:11","modified_gmt":"2026-11-09T14:56:11","slug":"%e6%b5%b7%e9%a6%ac%e5%8f%b0%e3%81%8b%e3%82%89%e5%86%85%e5%81%b4%e5%97%85%e5%86%85%e9%87%8e%e3%81%b8%e3%81%aegaba%e4%bd%9c%e5%8b%95%e6%80%a7%e6%8a%95%e5%b0%84%e3%82%92%e7%a2%ba%e8%aa%8d%ef%bc%88","status":"publish","type":"post","link":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/en\/%e6%b5%b7%e9%a6%ac%e5%8f%b0%e3%81%8b%e3%82%89%e5%86%85%e5%81%b4%e5%97%85%e5%86%85%e9%87%8e%e3%81%b8%e3%81%aegaba%e4%bd%9c%e5%8b%95%e6%80%a7%e6%8a%95%e5%b0%84%e3%82%92%e7%a2%ba%e8%aa%8d%ef%bc%88\/","title":{"rendered":"GABAergic subiculum\u2013medial entorhinal projection in mice and rats \uff08Kitanishi Group\uff09"},"content":{"rendered":"\n<p>A new study from the Kitanishi Group has been published in <em>Cerebral Cortex<\/em>.<br>The subiculum (SUB) serves as a major output relay of the hippocampus, transmitting information to both cortical and subcortical regions. Long-range projections from the SUB have generally been considered exclusively excitatory. In this study, however, we used selective labeling techniques for GABA-releasing neurons and demonstrated that the dorsal SUB sends inhibitory projections to the dorsal medial entorhinal cortex (MEC) in both mice and rats.<br>In mice, GABAergic neurons in the dorsal SUB projected sparsely throughout all layers of the MEC, with a higher density in the superficial layers. In contrast, glutamatergic SUB axons primarily targeted layer V of the MEC. Electrophysiological analyses further confirmed that these GABAergic axons formed functional inhibitory synapses within the MEC. A subset of the projection neurons expressed parvalbumin (PV), whereas only a small proportion were positive for somatostatin. Experiments specifically tracing PV neurons also revealed similar SUB-to-MEC projections.<br>In rats, GABAergic axons originating from the SUB were distributed predominantly in layer II of the MEC. Moreover, the labeled presynaptic terminals were positive for a GABA transporter, supporting the formation of inhibitory synapses. Tracing of PV neurons likewise reproduced a similar layer-specific distribution pattern in the MEC.<br>Together, these findings demonstrate that PV-associated inhibitory projections from the SUB to the MEC are conserved in both mice and rats and exhibit distinct laminar organization. This discovery expands the current understanding of SUB outputs, which have traditionally been regarded as purely excitatory.<br><br>Congratulations!<br>Cerebral Cortex : <a href=\"https:\/\/doi.org\/10.1093\/cercor\/bhag177\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1093\/cercor\/bhag177<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study from the Kitanishi Group has been published in Cerebral Cortex.The subiculum (SUB) serves as a maj [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/?p=1267","footnotes":"","_links_to":"","_links_to_target":""},"categories":[8],"tags":[],"class_list":["post-1272","post","type-post","status-publish","format-standard","hentry","category-publications","en-US"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/posts\/1272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/comments?post=1272"}],"version-history":[{"count":3,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/posts\/1272\/revisions"}],"predecessor-version":[{"id":1276,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/posts\/1272\/revisions\/1276"}],"wp:attachment":[{"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/media?parent=1272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/categories?post=1272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/plaza.umin.ac.jp\/dynamic-brain\/wp-json\/wp\/v2\/tags?post=1272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}