INTERFACE

1.Vacuolar

1)Lymphocyte predominate


     a)Ballooning and individual necrotic keratinocyte

               ・Normal cornified layer--------Erythema multiforme 
               ・Parakeratosis----------------Mucha-Habermann disease
               ・Prominent granular layer------Graft vs. host reaction
               ・Necrotic keratinocytes 
                  in papillary dermis also-------Effects of nitrogen mustard on
                                                                 mycosis fungoides, patch/plaque

      b)No abllooning and few,if any,necrotic keratinocyte

               ・ cornified layer normal----------Drug eruption (one type)

               ・Basement membrane sometimes 
                thickened,smudged interface,  
                thinned epidermis---------------Discoid lupus erythematosus
                                                                       /Dermatomyositis

                ・Screrosis in upper part of dermis----Lichen sclerosus et atrophicus (rnorphea)

                ・Melanophages in papillary dermis----Postinflarnmatory  pigrnentary alteration


2)Eosinophiles and Neutrophiles prominent


        a)Ballooning and individual necrotic keratinocyte

                 ・Cornifyed layer normal--------Fixed drug eruption, superficial

2.Lichenoid

1)Lymphocyte predominate


         a)Jagged epiderrnal hyperplasia, wedged hypergranulosis.
            compact orthokeratosis

                     Lichen planus


         b)Eosinophils sornetimes, focally thinned epiderrnis, focal parakeratosis

                     Lichen planus-like drug erupiion
                     Lichenoid photodermatitis


          c)Individual necrotic keratinocytes, ballooning, spongiosis, pallor in
             upper part of epidermis. and parakeratosis

                     Mucha-Habermann disease


           d)Lymphocytes along adnexal structures in reticular dermis,
              individual necrotic keratinocytes

                      Lichen striatus


            e)Thinned epiderrnis, prorninent granular layer, parakeratosis

                      Graft vs. host reaction


            f)Extravasated erythrocytes and/or siderophages

                       Lichenoid purpura of Gougerot and Blum


            g)Necrotic keratinocyles, focal parakeratosis,
               residuum of solar lentigo somtimes

                       Lichen planus-like keratosis


             h)Cornoid lamellae

                       Disserninated superficial actinic
                       porokeratosis


             i)Lymphocytes within epidermis, scant spongiosis

                        Mycosis fungoides, plaque


2)Histiocytes predominate

 
            a)Discrete foci in papillary dermis

                        Lichen nitidus


             b)Discrete foci and. sometimes, confluence of foci in reticular dermis

                        Sarcoidosis


3)Langerhans' cells predominate


              a)Large cells. crenulated outlines of large pale nuclei,
                 abundant amphophilic cytoplasm

                        Letterer-Siwe disease
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