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東京大学医学部附属病院
口腔顎顔面外科・矯正歯科
〒113-8655
東京都文京区本郷7-3-1
TEL 03(3815)5411
内線33714
FAX 03(5800)6832
なお、医療関係のご質問は一切お受けできませんので、あらかじめご了承下さい。
受診希望の方は、予約センター
TEL 03(5800)8630
までお願い致します。

研究内容

基礎研究

研究項目

  1. 再生医療による顎顔面領域の骨・軟骨再生
  2. インプラント型再生軟骨作製のためのヒト細胞を用いた基礎研究
  3. iPS細胞を用いた軟骨再生の研究
  4. 骨軟骨細胞分化制御機構における細胞周期関連分子の役割
  5. 間葉系細胞の多分化能維持機構における転写因子の役割
  6. 骨髄間葉系幹細胞を用いた骨・軟骨再生研究
  7. 口腔がん・口腔前がん病変におけるエピジェネティクス異常
  8. 口腔扁平上皮癌における腫瘍会合性マクロファージの宿主免疫抑制機構と癌増殖転移機構の解明

代表的な研究成果

  1. Fujihara Y, Hikita A, Takato T, Hoshi K. Roles of macrophage migration inhibitory factor in cartilage tissue engineering. J Cell Physiol. (in press)
  2. Kanazawa S, Nishizawa S, Takato T, Hoshi K. Biological roles of glial fibrillary acidic protein as a biomarker in cartilage regenerative medicine. J Cell Physiol. (in press)
  3. Ishibashi M, Hikita A, Fujihara Y, Takato T, Hoshi K. Human auricular chondrocytes with high proliferation rate show high production of cartilage matrix. Regenerative Therapy. 2017 Jun; 6: 21-28.
  4. Hikita A, Chung UI, Hoshi K, Takato T. Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer(). Tissue Eng Part A. 2017 Jun;23(11-12):515-521.
  5. Yonenaga K, Nishizawa S, Nakagawa T, Fujihara Y, Asawa Y, Hikita A, Takato T, Hoshi K. Optimal conditions of collagenase treatment for isolation of articular chondrocytes from aged human tissues, Regenerative Therapy. 2017 Jun; 6: 9-14.
  6. Kubota K, Moriyama M, Furukawa S, Rafiul HASM, Maruse Y, Jinno T, Tanaka A, Ohta M, Ishiguro N, Yamauchi M, Sakamoto M, Maehara T, Hayashida JN, Kawano S, Kiyoshima T, Nakamura S. CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma. Sci Rep. 2017 May 11;7(1):1755.
  7. Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S. Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun. 2016 Oct 28;479(4):772-778.
  8. Abe T, Sato T, Kokabu S, Hori N, Shimamura Y, Sato T, Yoda T. Zoledronic acid increases the circulating soluble RANKL level in mice, with a further increase in lymphocyte-derived soluble RANKL in zoledronic acid- and glucocorticoid-treated mice stimulated with bacterial lipopolysaccharide. Cytokine. 2016 Jul; 83: 1-7.
  9. Abe M, Yamashita S, Mori Y, Abe T, Saijo H, Hoshi K, Ushijima T, Takato T. High-risk oral leukoplakia is associated with aberrant promoter methylation of multiple genes. BMC Cancer. 2016 Jun 3;16:350.
  10. Hoshi K, Fujihara Y, Mori Y, Asawa Y, Kanazawa S, Nishizawa S, Misawa M, Numano T, Inoue H, Sakamoto T, Watanabe M, Komura M, Takato T. Production of three-dimensional tissue-engineered cartilage through mutual fusion of chondrocyte pellets. Int J Oral Maxillofac Surg. 2016 Sep;45(9):1177-85.
  11. Takato T. Tissue Engineering in Bone: The Contention of a Hundred Schools of Thought. Artif Organs. 2016 Apr;40(4):331-3.
  12. Fujihara Y, Nitta N, Misawa M, Hyodo K, Shirasaki Y, Hayashi K, Kosaka R, Homma K, Numano T, Kuribayashi S, Watanabe Y, Sato J, Ohtomo K, Takato T, Hoshi K. T2 and Apparent Diffusion Coefficient of MRI Reflect Maturation of Tissue-Engineered Auricular Cartilage Subcutaneously Transplanted in Rats. Tissue Eng Part C Methods. 2016 May;22(5):429-38.
  13. Suenaga H, Furukawa KS, Suzuki Y, Takato T, Ushida T. Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids. J Mater Sci Mater Med. 2015 Nov;26(11):254.
  14. Takato T, Mori Y, Fujihara Y, Asawa Y, Nishizawa S, Kanazawa S, Ogasawara T, Saijo T, Abe T, Abe M, Suenaga H, Kanno Y, Sugiyama S, Hoshi K: Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region. Oral Sci Int. 2014;11(2):45-51.
  15. Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T. Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2. Cell Reprogram. 2015 Jun;17(3):227-34.
  16. Fujihara Y, Takato T, Hoshi K. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells. 2014 May;32(5):1208-19.
  17. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports. 2014 May 22;2(6):751-60.
  18. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7.
  19. Uto S, Nishizawa S, Takasawa Y, Asawa Y, Fujihara Y, Takato T, Hoshi K. Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model. Biomed Res. 2013;34(6):281-8.
  20. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol. 2013 Jan;228(1):163-71.
  21. Yonenaga K, Nishizawa S, Fujihara Y, Asawa Y, Kanazawa S, Nagata S, Takato T, Hoshi K. Application of floating cells for improved harvest in human chondrocyte culture. Biomed Res. 2012;33(5):281-9.
  22. Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53.
  23. Tanaka Y, Saijo Y, Fujihara Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T, Asawa Y, Takato T, Hoshi K. Evaluation of the implant type tissue-engineered cartilage by scanning acoustic microscopy. J Biosci Bioeng. 2012 Feb;113(2):252-7.
  24. Ko EC, Fujihara Y, Ogasawara T, Asawa Y, Nishizawa S, Nagata S, Takato T, Hoshi K. BMP-2 embedded atelocollagen scaffold for tissue-engineered cartilage cultured in the medium containing insulin and triiodothyronine--a new protocol for three-dimensional in vitro culture of human chondrocytes. Tissue Eng Part C Methods. 2012 May;18(5):374-86.
  25. Iwata K, Asawa Y, Nishizawa S, Mori Y, Nagata S, Takato T, Hoshi K. The development of a serum-free medium utilizing the interaction between growth factors and biomaterials. Biomaterials. 2012 Jan;33(2):444-54.
  26. Kanazawa S, Fujihara Y, Sakamoto T, Asawa Y, Komura M, Nagata S, Takato T, Hoshi K. Tissue responses against tissue-engineered cartilage consisting of chondrocytes encapsulated within non-absorbable hydrogel. J Tissue Eng Regen Med. 2013 Jan;7(1):1-9.
  27. Asawa Y, Sakamoto T, Komura M, Watanabe M, Nishizawa S, Takazawa Y, Takato T, Hoshi K. Early stage foreign body reaction against biodegradable polymer scaffolds affects tissue regeneration during the autologous transplantation of tissue-engineered cartilage in the canine model. Cell Transplant. 2012;21(7):1431-42.

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