■つん読-paper │peripheral - melittin│   ←Bee venom


 
  Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):507-17.PubMed]
Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo.
 Hassid A, Levine L.
 
重要
 
  Exp Brain Res  100(1):18-28. (1994)[PubMed]
Activation of mechanonociceptors by pro-inflammatory peptides melittin and PLAP peptide.
 Cooper B, Bomalaski JS.
 (Department of Oral and Maxillofacial Surgery, JHM Health Center, University of Florida)
  • 麻酔ヤギのガッセル神経節から記録
  • PLAPよりもmelittinが強力にA/C mechanical and mechanoheat nociceptorを興奮させる。
  • phospholopase A2を活性化させる作用もあるが、侵害受容器を直接興奮させる可能性
     

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      Neuroscience  Volume 78, Issue 2, Pages 481-497 (10 March 1997)[Science Direct][PubMed]
    Localization of bradykinin-like immunoreactivity in the rat spinal cord: Effects of capsaicin, melittin, dorsal rhizotomy and peripheral axotomy
     P. Lopes and R. Couture
     (Department of Physiology, Faculty of Medicine, Universite' de Montre'al, C.P. 6128, Succursale Centre-Ville, Montreal,Que'bec Canada)

     

     
      Pain  Volume 84, Issues 2-3, Pages 133-139 (1 February 2000) [PubMed][Science Direct]
    Computer-assisted infrared thermographic study of axon reflex induced by intradermal melittin
     Natsu Koyama, Kazuhiko Hirata, Koichiro Hori, Kenjiro Dan and Toshikatsu Yokota
     (Department of Physiology, Shiga University of Medical Science, Japan)


     
      European Journal of Pain  Volume 6, Issue 6, Pages 447-453 (December 2002)[PubMed][Science Direct]
    Biphasic vasomotor reflex responses of the hand skin following intradermal injection of melittin into the forearm skin
     Natsu Koyama, Kazuhiko Hirata, Koichiro Hori, Kenjiro Dan and Toshikatsu Yokota
     (a Department of Physiology, Shiga University of Medical Science, Japan)

     

     
      Neuroscience Letters  Volume 337, Issue 3, Pages 147-15 (13 February 2003)  [PubMed][Science Direct]
    A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans
     H. Sumikura, O. K. Andersen, A. M. Drewesa and L. Arendt-Nielsen
     (Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark)

      Neuroscience  Volume 126, Issue 3 , 2004, Pages 753-762 ( 2004)  [PubMed][Science Direct]
    Altered pain-related behaviors and spinal neuronal responses produced by s.c. injection of melittin in rats
     K. -C. Lia and J. Chen
     (Research Center, Institute of Neuroscience, Fourth Military Medical University)

      Neuroreport. 2004 Aug 6;15(11):1745-9.  [*]
    Melittin selectively activates capsaicin-sensitive primary afferent fibers.
     Shin HK, Kim JH.


    その他
      Biophys J. 1981 Oct;36(1):109-16.  [PunMed]
    The sting. Melittin forms channels in lipid bilayers.
     Tosteson MT, Tosteson DC.
      Biochem. J. (1996) 315 (345-361)  [BJ]
    Review Peptide models for membrane channels
     Derek MARSH
     (Max-Planck-Institut für biophysikalische Chemie, Abt. Spektroskopie, D-37077 Göttingen, Federal Republic of Germany)

      Biochemistry, 36 (13), 3882 -3893, 1997. [*]
    Synergism between Mellitin and Phospholipase A2 from Bee Venom: Apparent Activation by Intervesicle Exchange of Phospholipids
     Yolanda Cajal and Mahendra Kumar Jain
      Biochemical and Biophysical Research Communications Volume 238, Issue 2 , 18 September 1997, Pages 436-442
    Melittin Binds to Secretory Phospholipase A2and Inhibits Its Enzymatic Activity
     Shamsher S. Saini, Johnny W. Peterson1 and Ashok K. Chopra[Science Direct]
      Acta Pharmacol Sin. 2000 Sep;21(9):841-4.  [PubMed]
    Effect of melittin on potassium currents and action potential in ventricular myocytes of guinea pig.
     Zhang XM, Yang S, He XJ, Zheng P, Jiang MH.
    (Department of Pharmacology, School of Pharmacy, State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, China.)

      Acta Pharmacol Sin. 2000 Sep;21(9):841-4.  [JP]
    Early metabolic inhibition-induced intracellular sodium and calcium increase in rat cerebellar granule cells
     Wei-Hao Chen, Kuan-Chou Chu, Shyh-Jong Wu, Jiahn-Chun Wu, Hao-Ai Shui and Mei-Lin Wu
    (Institutes of Physiology and Anatomy, College of Medicine, National Taiwan University )

      Toxicon Volume 40, Issue 5 , May 2002, Pages 519-526
    Role of melittin-like region within phospholipase A2-activating protein in biological function
     Deborah A. Ribardo, Kristine R. Kuhl, Johnny W. Peterson and Ashok K. Chopra
    (Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1070, USA)

    [Science Direct]
      Neuroscience Volume 135, Issue 2 , 2005, Pages 485-495
    Phospholipase A2 activation by melittin enhances spontaneous glutamatergic excitatory transmission in rat substantia gelatinosa neurons
     H.-Y. Yue, T. Fujita and E. Kumamoto[Science Direct]
      Neuropeptides Volume 40, Issue 3, June 2006, Pages 207-212
    The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats
     Murat Yalcina, Fusun Ak and Melih Erturk[Science Direct]
      Neuropeptides Volume 41, Issue 2, April 2007, Pages 103-110
    The involvement of the central cholinergic system in the pressor and bradycardic effects of centrally administrated melittin in normotensive conscious rats
     Murat Yalcina and Melih Erturk[Science Direct]


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