■つん読-paper | │peripheral - ketamine│ |
European Journal of Pharmacology
Volume 450, Issue 2, Pages 153-162 (23 August 2002) Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine Jana Sawynok and Allison Reid (Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada) | ||
Pain
Volume 102, Issues 1-2, Pages 179-186 (March 2003) Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats Jana Sawynok and Allison Reid (Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada) | ||
Anesth Analg
;97:168-173 (July 2003) Peripheral Antihyperalgesic and Analgesic Actions of Ketamine and Amitriptyline in a Model of Mild Thermal Injury in the Rat Mark Oatway, Allison Reid, and Jana Sawynok (Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada) | ||
British Journal of Anaesthesia. London
Vol. 77, Iss. 4; p. 441 (4 pages) Ketamine: Its mechanism(s) of action and unusual clinical uses K Hirota, D G Lambert. | ||
Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1347-55. Ketamine blocks Ca2+-activated K+ channels in rabbit cerebral arterial smooth muscle cells.[PubMed] Han J, Kim N, Joo H, Kim E. | ||
Clinical Physiology and Functional Imaging
Volume 24ハIssue 2ハPage 103ハ - March 2004 Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans[blackwell] Hanne Gottrup, Flemming Winther Bach and Troels Staehelin Jensen | ||
*鎮痛作用、幻覚作用、交感神経刺激作用を特徴とする全身麻酔薬Link
*麻酔量より低用量で鎮痛作用
*NMDA受容体の非競合的阻害薬
*モノアミンの再取り込み阻害することにより下行性疼痛抑制系を活性化 ←参考