■つん読-paper │peripheral - glutamate│

　

Dr Carlton関連


　		　 Neuroscience Letters 　Volume 197, Issue 1, Pages 25-28 (1 July 1995) [Science Direct]
Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin
　Susan M. Carltona,, Gregory L. Hargetta and Richard E. Coggeshall
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, TX USA)

　		　 Brain Research 　Volume 785, Issue 1, Pages 136-142 (23 February 1998) [Science Direct]
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors
　S Elyad M. Davidsonb and Susan M. Carlton
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, TX USA)
　

　		　 Brain Research 　Volume 790, Issues 1-2, Pages 160-169 (20 April 1998) [Science Direct]
Evidence for the interaction of glutamate and NK1 receptors in the periphery
　Susan M. Carlton, Shengtai Zhou and Richard E. Coggeshall
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch)

　		　 The Journal of Comparative Neurology 　Volume 391, Issue 1 , Pages 78 - 86 (1998) [Wiley]
Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery
　Richard E. Coggeshall, Susan M. Carlton
　(Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, Texas 77555-1069)

　		　 Brain Research 　Volume 820, Issues 1- , Pages 63-70 (27 February 1999) [Science Direct]
Inflammation-induced changes in peripheral glutamate receptor populations
　S. M. Carlton and R. E. Coggeshall
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, TX USA)
  • ハロセン麻酔下に、足蹠に28-ゲージの注射針で、CFA (Sigma-Aldrich)を100マイクロリッター　48時間後
  • 行動：thermal hyperalgesia--- paw withdrawal latency (PWL) to radiant heat短縮
    　　　mechanical allodynia---paw withdrawal threshold to mechanical stimulation
  • 電顕：CFAラットで、有髄軸索および無髄軸索の、NMDAR1, (NMDA receptors), (B) GluR1 (AMPA receptors), and (C) GluR5,6,7 (KA receptors)のすべてが増加。

　		　 Neuroscience Letters 　Volume 283, Issue 2, Pages 149-152 (7 April 2000) [Science Direct]
Localization of ionotropic glutamate receptors in peripheral axons of human skin
　Ilka Kinkelina, Eva-Bettina Bro"ckera, Martin Koltzenburgb and Susan M. Carlton
　(Department of Dermatology, Bayerische Julius-Maximilians-Universita"t, Wu"rzburg, Germany)
  • 正常ヒトの免疫電顕：axons at the dermal-epidermal junctionにはNMDA, AMPA (GluR2/3) or KA r eceptors (GluR5/6/7)
    Schwann cell にはNMDA or KA receptors.

　		　 NeuroReport 　VOLUME: 11, ISSUE: 03, PAGES: 0497-0502 (February 28 2000) [?]
Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation
　John deGroot, Shengtai Zhou, Susan M. Carlton
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX, USA)
  • 坐骨神経電気刺激 or カプサイシン刺激して後肢足蹠のグルタミン酸
    　A線維刺激---5min; 0.1ms pulse; 4 Hz strength: 2x, 10x, 20x, 50xTH (20-500μA)
    　A+C線維刺激---0.5ms pulse duration; 4Hz at 200xTH (>2mAmp)
  • CMA/20 microsialysis probe (CMA/Microdialysis, Acton, MA; 20kDa mol, wt cutoff, 4mm probe legth)
    　Using infusion pump lactated ringers solution (pH7.4) was infused (3μl/min) for a 120 min washout period, followed by a 60 min collection period to establish EAA sampling every 10 min.
    　 Samples were analyzed for EAA concentrations using reverse phase high performance liquid chromatography (HPLC) equipped with a fluorescence detector.

　		　 Pain 　Volume 89, Issues 2-3, Pages 187-198 (January 2001) [Science Direct]
Glutamate-induced excitation and sensitization of nociceptors in rat glabrous skin
　Junhui Du, Martin Koltzenburg and Susan M. Carlton
　(Department of Dermatology, Bayerische Julius-Maximilians-Universita"t, Wu"rzburg, Germany)
　
　 Current Opinion in Pharmacology Volume 1, Issue 1, 1 February 2001, Pages 52-56[Science Direct]
Peripheral excitatory amino acids (Review)
　Susan M. Carlton
　 Nature Neuroscience 　Volume 4 Number 4 pp 417 - 4239 (April 2001) [Nature]
Peripheral group I metabotropic glutamate receptors modulate nociception in mice
　G. Bhave, F. Karim, S. M. Carlton & R. W. Gereau IV
　(Division of Neuroscience, Baylor College of Medicine, USA)

　		　 Neuroscience 　Volume 105, Issue 4 , 22, Pages 957-969 (August 2001) [Science Direct]
Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat
　S. M. Carlton, G. L. Hargett and R. E. Coggeshall
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch)

　		　 Brain Research 　Volume 913, Issue, Pages 18-26 (14 September 2001) [Science Direct]
Metabotropic glutamate 1 α receptors on peripheral primary afferent fibers: their role in nociception
　Shengtai Zhou, Spogmai Komak, Junhui Du and Susan M. Carlton
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch)
  • 　　　

　		　 Neuroscience 　Volume 118, Issue 2, Pages 547-562 (8 May 2003) [Science Direct]
N-methyl- D-aspartate-induced excitation and sensitization of normal and inflamed nociceptors
　J. Du, S. Zhou, R. E. Coggeshall and S. M. Carlton
　(Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, USA)
  • 浮腫（thickness）、発赤（score）、皮膚温（contact thermode）：CFAの注入前、２，７，１４日後の左右差を比較。どれも２日目が一番変化あり。
  • 電顕：digital nervesの無髄軸索の NMDAR1は normal ratにもあるが、後肢足蹠CFA注入2,7日後に増加しているが、14日ではnormalと有意差なし。
  • 行動：(1)正常ラットでは、足蹠への1 mM NMDA注入で、von Freyでの機械刺激による感受性が有意に閾値低下。
    　(2)CFA炎症ラットの機械刺激による感受性の閾値は正常ラットよりも低く、CFA炎症ラットへでは、0.5 mM NMDA注入でも有意に閾値低下。
    　(3)CFA注入２日後に同側足蹠にMK-801を注入すると、閾値の低下から回復（PBS注入,対側足蹠に注入したMK-801と比較）。
  • 電気生理：In vitro skin-nerve: medial and lateral plantar nerves, single-unit studies, C-mechanoheat (CMH) receptors or C-mechanoreceptors (CM)
    (1)2-day CFA-inflamed glabrous skinでは、熱刺激の閾値の低下
    (2)足蹠に投与されるNMDAによって興奮する受容器の割合および発火数の増加はinflamed skinのほうが多く、dose dependencyがある。
    (3)NMDA２回注入により感受性が亢進。２回目にMK-801も一緒に注入すると、健常皮膚では初回注入時と同じ反応性、炎症皮膚では初回注入時よりもスパイク数減少。
    (3) NMDA注入前後で、熱反応を比較。健常皮膚では、NMDA注入後に閾値の低下と発火数増加。炎症皮膚では、閾値の低下のみ。
  • 末梢NMDA受容体の活性化は急性の侵害受容と持続性の炎症における痛みに関与する。炎症動物時での、末梢軸索にNMDAR1のアップレギュレーション（？）と活性化が、持続する炎症に伴われる機械痛覚過敏と熱痛覚過敏に関与する。鎮痛薬の末梢でのターゲットとなる可能性がある。

　		　 Neuroscience 　Volume 93, Issue 2, Pages 713-722 ( July 1999) [Science Direct]
Peripheral GABAA receptors: evidence for peripheral primary afferent depolarization
　S. M. Carlton, S. Zhou and R. E. Coggeshall
　(Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX)

　		　 Pain 　Volume 110, Issue 1-2, Pages 10-21 ( July 2004) [Science Direct]
Pro-nociceptive role of peripheral galanin in inflammatory pain
　Juan Miguel Jimenez-Andrade, Shengtai Zhou, Junhui Du, Ammar Yamani, James J. Grady, Gilberto Casta貌da-Hernandez and Susan M. Carlton
　(Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX)

　		　 Pain 　Volume 110, Issue 3, Pages 616-627 ( August 2004) [Science Direct]
Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel
　Susan M. Carlton, Shengtai Zhou, Junhui Du, Gregory L. Hargett, Guangchen Ji and Richard E. Coggeshal
　(Department of Anatomy and Neuroscience, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX)

Dr Sessle & Dr Arendt-Nielsen関連


　		　 J Neurophysiol 　86: 782-791, 2001 (August 2001) [JNP]
Sex-Related Differences in Human Pain and Rat Afferent Discharge Evoked by Injection of Glutamate Into the Masseter Muscle
　LBrian E. Cairns,1 James W. Hu, Lars Arendt-Nielsen, Barry J. Sessle,1 and Peter Svensson
　(Faculty of Dentistry, The University of Toronto, Toronto, Ontario M5G 1G6, Canada)

　		　 Neuroscience 　Volume 109, Issue 2, Pages 389-399 (28 January 2002) [Science Direct]
Glutamate-induced sensitization of rat masseter muscle fibers
　B. E. Cairnsa, G. Gambarotaa, P. Svenssonb, c, d, L. Arendt-Nielsenb and C. B. Berde
　(Department of Anesthesia, Harvard Medical School USA)

　		　 Pain 　Volume 101, Issue 3 , Pages 221-227 (February 2003) [Science Direct]
Glutamate-evoked pain and mechanical allodynia in the human masseter muscle
　Peter Svensson, Brian E. Cairnsd, Kelun Wangb, James W. Hue, Thomas Graven-Nielsenb, Lars Arendt-Nielsenb and Barry J. Sessle
　(Department of Clinical Oral Physiology, Dental School, Aarhus University, DK-8000, Aarhus C, Denmark)

　		　 J Neurophysiol 90: 2098-2105, 2003 [Science Direct]
Activation of Peripheral NMDA Receptors Contributes to Human Pain and Rat Afferent Discharges Evoked by Injection of Glutamate into the Masseter Muscle
　Brian E. Cairns1, Peter Svensson, Kelun Wang, Steen Hupfeld, Thomas Graven-Nielsen, Barry J. Sessle, Charles B. Berde and Lars Arendt-Nielsen
　(Department of Anesthesia, Harvard Medical School/Children's Hospital, Boston Massachusetts, 02115)

　		　 Pain 124(3) 2006, 338-348 [Science Direct]
Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women
　Parisa Gazerani, Kelun Wang, Brian E. Cairns, Peter Svensson, and Lars Arendt-Nielsen
---thermography

　		　 Brain Research Bulletin Volume 72, Issue 1, 2 April 2007, Pages 10-17 [Science Direct]
Involvement of peripheral ionotropic glutamate receptors in activation of cutaneous branches of spinal dorsal rami following antidromic electrical stimulation of adjacent afferent nerves in rats
　Dong-Yuan Caoa, Hao-Jun Youa, b, c, 1, Yan Zhao, Yuan Guoa, b, Hui-Sheng Wang, Lars Arendt-Nielsen, Hui-Ling Wang and Qi Zhang

Dr Calixto関連


　		　 Brain Research 　Volume 924, Issue 2, Pages 219-228 (11 January 2002) [Science Direct]
Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw
　Alessandra Beirith, Adair R. S. Santos and Joa~o B. Calixto
　(Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina, Brazil)

　		　 Brain Research 　Volume 969, Issues 1-2, Pages 110-116 (18 April 2003) [Science Direct]
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice
　Alessandra Beirith, Adair R. S. Santos and Joa~o B. Calixto
　(Department of Pharmacology, Centre of Biological Sciences, Federal University of Santa Catarina, Brazil)

　		　 Neuropharmacology 　Volume 43, Issue 3, Pages 340-347 (September 2002) [Science Direct]
Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial
　C. Scheidta, A. R. S. Santosa, J. Ferreiraa, A. Malheirosc, V. Cechinel-Filhob, R. A. Yunesc and J. B. Calixto
　(Department of Pharmacology, Center of Biological Sciences, UFSC, Floriano'polis, SC, Brazil)

Dr Sawynok関連


　		　 Journal of Neurochemistry, 80 (4) 562-570, February 2002 [Blackwell]
Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents
　Xue Jun Liu, Thomas D. White and Jana Sawynok

　		　 Neuroscience 　Volume 787, Issue 1, Pages 161-164 (2004) [PubMed][Science Direct]
Glutamate-evoked release of adenosine and regulation of peripheral nociception
　N. Aumeerallya, G. Allenb and J. Sawynok
　(Department of Pharmacology and Anatomy, Dalhousie University, Halifax, Nova Scotia, Canada)

その他


　		　 Neurosci Lett. 　Volume 260, Issue 2, Pages 89-92 (1999 Jan 29) [PubMed][Science Direct]
Peripheral administration of an N-methyl-D-aspartate receptor antagonist (MK-801) changes dorsal horn neuronal responses in rats.
　Ushida T, Tani T, Kawasaki M, Iwatsu O, Yamamoto H.

　		　 Brain Research 　Volume 787, Issue 1, Pages 161-164 (16 March 1998) [Science Direct]
Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw
　Keiichi Omote, Tomoyuki Kawamata, Mikito Kawamata and Akiyoshi Namiki

　		　 ANESTHESIOLOGY 2000;93:173-178 　;3:173-178 (2000)
Activation of Peripheral NMDA-Nitric Oxide Cascade in Formalin Test
　Keiichi Omote, M.D.; Tomoyuki Kawamata, Mikito Kawamata, Yoshito Nakayama, Koji Hazama, Akiyoshi Namiki
　(Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060, Japan)

　		　 Pain 　Volume 86, Issues 1-2, Pages 69-74 (1 May 2000) [Science Direct]
Amino acid release into the knee joint: key role in nociception and inflammation
　Nada B. Lawanda, Terry McNearneyb and Karin N. Westlund
　(Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch at Galveston, TX, USA)
　

　		　 The Journal of Neuroscience 　(15):6388-6393 (August 1, 2002, 22) [JNS]
Peripheral Group II Metabotropic Glutamate Receptors (mGluR2/3) Regulate Prostaglandin E2-Mediated Sensitization of Capsaicin Responses and Thermal Nociception
　Dongni Yang1 and Robert W. Gereau IV1, 2
　(Department of Molecular Physiology and Biophysics , Baylor College of Medicine, Houston, Texas USA)

　		　 Journal of Neurochemistry 　Volume 80 Issue 4 Page 562 (February 2002) [BW]
Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents
　Xue Jun Liu, Thomas D. White and Jana Sawynok
　(Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada)

　		　 Neuroscience 　Volume 128, Issue 1 , 2004, Pages 169-176 [Science Direct]
Peripheral glutamate receptors contribute to mechanical hyperalgesia in a neuropathic pain model of the rat
　J.H. Janga, D.-W. Kima, T. Sang Nama, K. Se Paika and J.W. Leem
　(Department of Physiology, Yonsei University College of Medicine, C.P.O. Box 8044, Seoul)

トランスポーターなど


　		　 The Journal of Neuroscience 23(7):2899 (April 1, 2003) [JNS]
Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the Pathogenesis of Neuropathic Pain in Rats
　Backil Sung, Grewo Lim, and Jianren Mao
　(Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts)

　		　 Brain Research Volume 945, Issue 2 (2 August 2002) [Science Direct]
Glutamine-, glutamine synthetase-, glutamate dehydrogenase- and pyruvate carboxylase-immunoreactivities in the rat dorsal root ganglion and peripheral nerve
　Kenneth E. Miller, Brent A. Richardsa and Richard M. Kriebelb
　(Department of Cell Biology, BMSB 562, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA)
　グルタミン酸は、脊髄内終末だけではなく、DRGや軸索でも作られることを、免疫学学的手法によって、合成酵素をsatellite cellsや Schwann cellsで染めて示した。
　　→TCAサイクルなどのわかりやすいシャーマ

末梢以外を含む


　		　 Anesth Analg 　97:1108-1116 (2003) [A & A]
The Role of N-Methyl-D-Aspartate (NMDA) Receptors in Pain: A Review
　Andrei B. Petrenko, Tomohiro Yamakura, Hiroshi Baba, and Koki Shimoji
　(Department of Anesthesiology, Niigata University School of Medicine)