Constriction of Mitochondrial inner-compartments (CoMICs), hidden mitochondrial dynamics for the control of mitochondrial morphology and function
Woong Sun, Ph.D
Professor, Department of Anatomy, Korea University College of Medicine
場所：慶應義塾大学信濃町キャンパス 総合医科学研究棟４階 会議室４
Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development. Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Kanehiro Hayashi, Arata Nagasaka, Seika Inoue, Takaki Miyata, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima. Proc. Natl. Acad. Sci. U.S.A., in press. (Y. Matsunaga and M. Noda are co-first authors)
INSTITUT DE LA VISION, INSERM UMRS 968
“3D analysis of axon guidance in transparent vertebrate embryos: of mice and men.”
会場：慶應義塾大学信濃町キャンパス 総合医科学研究棟３階 会議室３
Robo receptors play a major role in the control of axon guidance at the midline of the central nervous system. In vertebrates, a divergent Robo family member Robo3 is expressed by commissural axons of the mouse spinal cord and hindbrain before and during crossing of the ventral midline (the floor plate), and many commissures fail to develop in mice and humans lacking Robo3. We found that the Robo3 receptor fundamentally changed its mechanism of action during mammalian evolution. Interestingly, we found that the Netrin-1 receptor DCC does not exist in all vertebrates. Our results suggest that commissural axon guidance mechanisms may be more diverse across species than previously appreciated. This work might help understanding the emergence of specific sensory, motor and cognitive functions and why they differ between species. To facilitate the analysis of commissural systems in vertebrates, we have developed a new imaging method which combines whole-mount immunostaining, tissue clearing and light-sheet microscopy. I will present new applications of this method to provide the first comprehensive description of development in human embryos during the first trimester of gestation.
Proper level of cytosolic Disabled-1, which is regulated by dual nuclear translocation pathways, is important for cortical neuronal migration. Takao Honda and Kazunori Nakajima. Cereb. Cortex, 26 (7), 3219-3236 (2016).
Mutually repressive interaction between Brn1/2 and Rorb contributes to establishment of neocortical layer 2/3 and layer 4.
Koji Oishi, Michihiko Aramaki, and Kazunori Nakajima
Proc. Natl. Acad. Sci. U.S.A., in press.
Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex.
Koji Oishi, Nao Nakagawa, Kashiko Tachikawa, Shinji Sasaki, Michihiko Aramaki, Shinji Hirano, Nobuhiko Yamamoto, Yumiko Yoshimura, and Kazunori Nakajima
eLife, in press.
(Highlighted in a Journal Club feature in the January 27 (2016) issue of The Journal of Neuroscience. Author response was also posted online.) http://www.jneurosci.org/content/36/4/1051?etoc
Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits.
Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima. J. Neurosci., in press. (K. Ishii and K. Kubo are co-first authors)
石井先生は今月から、Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciencesに移られます。おめでとうございます！