The Journal of Neuroscience 論文受理のお知らせ!

北澤彩子先生、久保健一郎先生、林周宏先生による海馬論文が、このたび「The Journal of Neuroscience」に掲載されることになりました。
"Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel "climbing" migration mode during development"


“発生期大脳皮質におけるリーリンシグナルの神経細胞移動と層構造形成への役割の解析” この賞は、公益財団法人の井上科学振興財団により、自然科学の分野で優れた博士論文を提出した若手研究者に対し贈呈されます。 贈呈式は2014年2月4日に行われます。 http://www.inoue-zaidan.or.jp/


学校法人桐朋学園 桐朋中学・高等学校、国立(東京都)、2013年11月19日


Víctor Borrell
Instituto de Neurociencias, CSIC & Universidad Miguel Hernández

“Mechanisms of expansion and folding of the mammalian cerebral cortex”

会場:慶應義塾大学信濃町キャンパス 総合医科学研究棟1階ラウンジ

問い合わせ:松本 matsumotoyuko@a5.keio.jp


Prof. Zoltan Molnar
Department of Physiology, Anatomy and Genetics, University of Oxford
"Evolution of cerebral cortical development"
会場:慶應義塾大学信濃町キャンパス 総合医科学研究棟


形態形成セミナー 鳥居和枝先生 

場所:慶應義塾大学信濃町キャンパス総合医科学研究棟 2階 会議室2

Principal Investigator, Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center
Assistant Professor, Department of Pediatrics, Pharmacology and Physiology
, The George Washington University School of Medicine and Health Sciences
Visiting Assistant Professor, Department of Neurobiology, School of Medicine, Yale University

Interaction of Heat Shock Signaling and Prenatal Environment in Neuropsychiatric Disorders.

The developing human brain, when exposed prenatally to various types of environmental challenges, displays increased susceptibility to late-onset neuropsychiatric dysfunction, though the mechanism remains obscure. We recently found that exposure of the human and mouse embryonic cerebral cortex to the challenges such as alcohol and methylmercury activates HSF1 mediated Heat Shock Signaling. In addition, Hsf1 deficiency causes the emergence of structural abnormalities in the mouse cortex upon in utero exposure to subthreshold levels of these challenges, and increases seizure susceptibility after birth. Furthermore, neural progenitor cells differentiated from human induced pluripotent stem cells of Schizophrenia patients show higher variability in the level of challenge-induced HSF1 activation. Altogether, our findings uncover the role of HSF1 in conferring tolerance to prenatal environmental perturbations in the normal cerebral cortex, thereby securing a lowered manifestation of neuropsychiatric disorders, and suggest that HSF1 malresponse may be a key component of the pathogenesis of these disorders.


井上科学振興財団のホームページ http://www.inoue-zaidan.or.jp/ に詳細が掲載されております。