Manabe Lab.
Department of Systems Medicine, Chiba University
We are interested in the molecular mechanisms of cardiovascular, metabolic, and kidney diseases and the translation of basic science into novel therapeutic strategies. Our current projects focus on immunometabolic mechanisms in chronic inflammatory diseases and the maintenance of homeostasis via multi-system interactions. We analyze the crosstalk between metabolism and immunity at the cellular, tissue, and systemic levels. We are particularly interested in the divergent functions and phenotypes of macrophages in physiology and pathobiology. We employ a variety of technologies, including NGS, single-cell analysis, FACS, and in vivo imaging.
Streamlit NGS Analysis App Suite
→ METIS
Our paper showing that hematopoietic stem cells carry a memory of heart failure, leading to heart failure recurrence as well as multimorbidity, is now published.
Postdoc and Graduate Student Positions Available
Contact: imanabe@chiba-u.jp
Interests • Innate immune memory • Heart failure and multimorbidity • Organ crosstalk/Organ system networks • Epigenetics/Single-cell analysis • Macrophage biology • Immunometabolism • Inflammaging