Manabe Lab.
Department of Systems Medicine, Chiba University
We are interested in molecular mechanisms of cardiovascular, metabolic and kidney diseases and translation of the basic science into novel therapeutic strategies. Our current projects focus on immunometabolic mechanisms in chronic inflammatory diseases and maintenance of homeostasis via the multi-system interaction. We are analyzing the crosstalk between metabolism and immunity at the cell, tissue and system levels. We are particularly interested in divergent functions and phenotypes of macrophages in physiology and pathobiology. We use a variety of technologies, including NGS, single-cell analysis, FACS, and in vivo imaging.
Our paper showing that hematopoietic stem cells carry a memory of heart failure leading to heart failure recurrence as well as multimorbidity is out.
Graduate Student positions are available.
Contact: imanabe@chiba-u.jp
Interests
Non-communicable disease
Organ crosstalk/Organ system network
Epigenetics/Single cell analysis
Macrophage
Immunometabolism
Inflammaging