研究業績

2019年

Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H. Mitofusin 2 is involved in chemotaxis of neutrophil-like diffrentiated HL-60 cells. Biochem Biophys Res Commun 513: 708-713 (2019).

Mazaki Y, Higashi T, Onodera Y, Nam JM, Hashimoto A, Hashimoto S, Horinouchi T, Miwa S. Endothelin type B receptor interacts with 78-kDa glucose-regulated protein. FEBS Lett 593: 644-651 (2019).

Mazaki Y, Higashi T, Horinouchi T, Miwa S. Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation. Biochem Biophys Res Commun 511: 69-72 (2019).

Mai Y, Ujiie H, Higashi T, Yamagami J, Iwata H, Shimizu H. Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection. Br J Dermatol 180: 215-216 (2019).

2018年

Higashi T, Mai Y, Mazaki Y. Protein kinase C-dependent cell damage by unsaturated carbonyl compounds in vascular cells. J Biosci Bioeng 126: 527-532 (2018).

2017年

Higashi T, Mai Y, Mazaki Y, Miwa S. Intracellular Ca2+ is an essential factor for cell damage induced by unsaturated carbonyl compounds. J Biosci Bioeng 124: 680-684 (2017).

Mazaki Y, Onodera Y, Higashi T, Horinouchi T, Oikawa T, Sabe H. ARF1 recruits to leading edge in neutrophil chemotaxisis. Cell Commun Signal 15: 36 (2017).

Kashiwagi H, Yuhki K, Imamichi Y, Kojima F, Kumei S, Higashi T, Horinouchi T, Miwa S, Narumiya S, Ushikubi F. Cigarette smoke extract inhibits platelet aggregation by suppressing cyclooxygenase activity. TH Open 1: e122 (2017).

2016年

Sugimoto C, Hirotani M, Yoshikiyo K, Koshimizu U, Wakao R, Horinouchi T, Mazaki Y, Higashi T, Fukazawa T, Fujita H, Sasaki H, Wakao H. The dynamics of mucosal-associated invariant T cells in multiple sclerosis. SpringerPlus 5: 1-16 (2016).

Horinouchi T, Higashi T, Mazaki Y, Miwa S. Carbonyl compounds in the gas phase of cigarette mainstream smoke and their pharmacological properties. Biol Pharm Bull 39: 909-914 (2016).

Higashi T, Mai Y, Mazaki Y, Horinouchi T, Miwa S. A standardized method for the preparation of a gas phase extract of cigarette smoke. Biol Pharm Bull 39: 898-902 (2016).

Horinouchi T, Hoshi A, Harada T, Higa T, Karki S, Terada K, Higashi T, Mai Y, Nepal P, Mazaki Y, Miwa S. Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells. Br J Pharmacol 173: 1018-1032 (2016).

2015年

Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuo Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M. Decreased proteosomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. Lab Invest 95: 625-634 (2015).

2014年

Terada K, Horinouchi T, Fujioka Y, Higashi T, Nepal P, Horiguchi M, Karki S, Hatate C, Hoshi A, Harada T, Mai Y, Phba Y, Miwa S. Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. J Biol Chem 289: 35283-35295 (2014).

Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada T, Horiguchi M, Hatate C, Kuge Y, Miwa S. A simple and rapid method for standard preparation of gas phase extract of cigarette smoke. PLOS ONE 9: e107856 (2014).

Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, Mai Y, Nepal P, Horiguchi M, Hatate C, Miwa S. Endothelin-1 activates extracellular signal-regulated kinases 1/2 via transactivation of platelet-derived growth factor receptor in rat L6 muoblasts. Life Sci 104: 24-31 (2014).

2013年

Noya Y, Seki K, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S. Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity. Toxicology 314: 1-10 (2013).

2012年

Mai Y*, Higashi T*, Terada K, Hatate C, Nepal P, Horiguchi M, Harada T, Horinouchi T, Miwa S. Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+-dependent subtype-specific protein kinase C activation. J Pharmacol Sci 120: 310-314 (2012). *These authors have equally contributed to this work.