The 84th Annual Meeting of
The Japanese Pharmacological Society
March 22-24, 2011
Yokohama, Japan
Chairman: Masamitsu Iino
Abstracts
Secretariat: Yohei Okubo
Department of Pharmacology, Graduate School of Medicine, The University of Tokyo
Contents
Plenary Lecture
PL
Aquaporin water channels: from atomic structure to clinical medicine
Peter Agre.......... 2P
SEAWP Special Lecture
SWSL
Control of atrial arrhythmias by microRNAs
Baofeng Yang .......... 4P
Special Lectures
SL1
Targeting ALK fusions in human cancer
Hiroyuki Mano .......... 8P
SL2
Novel mechanisms and treatments of heart failure
Issei Komuro .......... 8P
SL3
Molecular mechanism and treatment strategy of type 2 diabetes
Takashi Kadowaki .......... 8P
SL4
Prostaglandins and inflammation: a new concept from receptor-KO mouse studies
Shuh Narumiya .......... 8P
SL5
How to improve pharmaceutical research and development productivity: drug target discovery through product development
Masaomi Miyamoto .......... 9P
SL6
Alzheimer's disease: from molecular pathology to disease-modification
Takeshi Iwatsubo .......... 9P
Ebashi Setsuro Award Lecture
EAL
Glutamate receptors and brain function
Masayoshi Mishina............ 12P
Encouragement of Young Investigator Award Lectures
AL1
Elucidation of molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant γPKC
Takahiro Seki............ 14P
AL2
Study on the role of heterotrimetic G protein signaling pathways for the treatment of heart failure
Motohiro Nishida............ 14P
AL3
Pharmacological study on Alzheimer's drugs targeting for calcium/calmodulindependent protein kinase II
Shigeki Moriguchi............ 14P
SEAWP Symposia
SW1
Traditional medicine in modern pharmacology
Zhi-Bin Lin............ 16P
SW2
Pharmacometabolomics
Young-Ran Yoon............ 17P
SE3
Oxidative stress as a pharmacological target
Samuel H.H. Chan............ 18P
SW4
In vitro - in vivo extrapolation: realising the promise
John Miners............ 19P
ASCEPT-JPS Joint Symposium
ASJP
Ion channels in disease and as pharmacological targets
Gregory Monteith and Yasuo Mori .......... 22P
The Japanese Society of Clinical Pharmacology and Therapeutics-The Japanese Pharmacological Society Joint Symposium
JS
New pharmacological approach to alleviation of adverse drug reactions
Shinichiro Ueda and Ryozo Oishi............ 24P
JPS Symposia
S1A1
Research and development strategy of agents for cancer therapy
Yasuhiro Funahashi and Shiro Soga .......... 26P
S1B2
Inflammation in cardiovascular diseases
Haruaki Nakaya and Tetsushi Furukawa .......... 27P
S1C3
New findings about multiple roles of adenosine A1 receptors in the regulation of CNS functions
Yuko Sekino and Tomoaki Shirao .......... 28P
S1I4
Recent advances in the research on Rho family GTPase signaling and its application to pharmacology
Kozo Kaibuchi and Takehiko Ueyama .......... 29P
S1B5
A new turn of basic research for stem cells and medical science of epigenetics
Minoru Narita and Hirotaka J. Okano .......... 30P
S1C6
Molecular dynamics of G protein-coupled receptors revealed by imaging techniques
Hitoshi Kurose and Akira Hirasawa .......... 31P
S1I7
Protein kinase C-subtypes as molecular targets for the therapy of incurable diseases
Hiroyuki Fukui and Naoaki Saito .......... 31P
S1B8
Translational research for the development of Quality of Life of cancer patients - contribution by the pharmacological research approach
Yoshihiro Nakata and Yasuhito Uezono .......... 33P
S1C9
Molecular basis of exocytosis
Masato Hirata and Mitsunori Fukuda .......... 34P
S1H10
New transgenic mouse models for drug development
Hirofumi Kai and Tetsuya Taga .......... 35P
S1I11
The new approach for research of improvement of higher brain function
Kumiko Ishige and Naoko Kuzumaki .......... 36P
S1A12
Research and development strategy of agents for cardiovascular diseases
Toshiro Shibano and Akira Saito .......... 37P
S1C13
Current status and future scope of translational research on acute lung injury
Yuichi Hattori and Naoyuki Matsuda .......... 38P
S1H14
New therapeutic strategy for amino acid medicine
Koji Takeuchi and Hisayuki Uneyama .......... 39P
S1I15
Mechanisms underlying initiation and modulation of purinergic system
Schuichi Koizumi and Yoshinori Moriyama .......... 40P
S2A16
Research and development strategy of agents for schizophrenia
Takahiko Yano and Shigeyuki Chaki .......... 41P
S2C17
The research frontline of drug transport as the basis for drug discovery and therapeutic development
Naohiko Anzai and Hiroyuki Kusuhara .......... 42P
S2I18
Functional control of the brain and autonomic nervous system by new regulatory factors and their drug development
Nobuyuki Yanagihara and Kiyofumi Yamada .......... 43P
S2C19
Dysfunction of transportsome in diseases and its possibility as therapeutic targets: the next generation of transporter research
Satomi Kita and Takayuki Nakagawa .......... 44P
S2H20
Pathophysiological function and drug discovery of 5-hydroxytryptamine in gastrointestinal diseases
Masatoshi Hori and Shinichi Kato .......... 45P
S2I21
Application of imaging techniques for drug discovery of next generation
Toshio Tanaka and Masatoshi Hagiwara .......... 46P
S2C22
Environmental insults for psychiatric disorders on multiple life stages and the implications for pharmaceutical development
Tomoyuki Furuyashiki and Taku Yamaguchi .......... 47P
S2H23
Hydrogen sulfide as a signal molecule as well as a cytoprotectant
Hideo Kimura and Ichiro Niki .......... 48P
S2I24
An extremely small size mini-pig made in Japan (MicrominipigTM): evolution as a medical research tool
Atsushi Sugiyama and Yasukatsu Izumi .......... 49P
S2A25
Research and development of agents for pain
Toshiaki Aoki and Syuzo Watanabe .......... 50P
S2C26
The present and future of molecular imaging, and its potential for drug discovery and development
Kazuhiko Yanai and Hideaki Hara .......... 51P
S2H27
Approach of alternative to animal experiments in Asia
Yuji Yoshiyama .......... 52P
S2I28
Opening the era for drug design research driven by new microscopic technology
Mutsuo Nuriya and Yuji Ikegaya .......... 53P
S3A29
Translational research
Hisaharu Yamada and Segyoku Ryu .......... 54P
S3B30
New approaches to ion channels as a target for drug discovery and novel screening methods
Yuji Imaizumi and Syuji Kaneko .......... 55P
S3C31
Drugs for the treatment of metabolic bone disease: the development of drug therapy based on the new molecular mechanisms
Keiichi Otani and Akifumi Togari .......... 56P
S3I32
Frontier researches on biological imaging toward the development of novel drugs and therapeutics
Masaru Ishii and Satoshi Nishimura .......... 57P
S3C33
Development of drugs for brain ischemia: toward translational research
Masahiro Nishibori and Michihiro Fujiwara .......... 58P
S3I34
Structural biology and pharmacology: lessons from researches of GPCRs
Takuya Kobayashi and Takumi Misaka .......... 59P
S3C35
The next generation of deafness therapies targeting the inner ear
Hiroshi Hibino and Katsuhisa Ikeda .......... 60P
S3I36
Visualization of reactive oxygen species and its application to elucidation of signal transduction pathways
Motohiro Nishida and Akio Matsumoto .......... 61P
Free Communications
Oral Sessions ......... 63P
Poster Sessions .......... 129P
Author Index ............. 1
Subject Index ............. 37
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