The 83rd Annual Meeting of
The Japanese Pharmacological Society
March 16-18, 2010
Osaka, Japan
Chairman: Hiroshi Iwao
Abstracts
Secretariat: Yasuo Izumi
Osaka City University Graduate School of Medicine
Contents
Plenary Lecture
PL-1
What are the mechanisms which mediate the reputed clinical and tolerability
advantages of the atypical antipsychotic drugs
Herbert Y. Meltzer.......... 2P
PL-2
Angiotensin AT2 receptor agonism - a new pharmacological concept
for anti-inflammation and tissue-protection?
Thomas Unger.......... 2P
PL-3
Therapeutic drug assays. Can we do it better?
Raymond G. Morris.......... 2P
Special Lectures
SL1
A new era of pharmacological treatment of patients with type 2 diabetes mellitus
Atsunori Kashiwagi .......... 4P
SL2
Approach to drug discovery based on large-scale chemical library
Tetsuo Nagano .......... 4P
SL3
Interplay among the vascular, metabolic and immune systems in cardiovascular
remodeling and metabolic syndrome
Ryozo Nagai .......... 4P
SL4
Clinical Research -Translational Research and Evidence-Based Medicine
Kazuwa Nakao .......... 4P
SL5
Pharmacogenomics and Personalized Medicine
Junichi Azuma .......... 5P
SL6
Induction of pluripotency by defined factors
Shinya Yamanaka .......... 5P
SL7
Renin-Angiotensin system Inhibitors: Update in hypertension treatment
Kazuaki Shimamoto .......... 5P
SL8
Physiology and pathophysiology of neuropeptide PACAP: novel roles revealed by
gene targeting mouse studies
Akemichi Baba .......... 5P
Ebashi Setsuro Award Lecture
EAL
A neuropharmacological research on the functions of ATP receptors
Kazuhide Inoue............ 8P
Award Lectures
AL1
Pharmacological study of tissue-type plasminogen activator in ischemic stroke
Yasuhiro Suzuki............ 10P
AL2
Involvement of dysfunction of glia-neuron network in chronic pain and drug addiction
fetal calf serum
Takayuki Nakagawa............ 10P
AL3
The entrainment of the mammalian circadian clock via the induction of Period
genes
Takahiro Moriya............ 10P
The Japanese Pharmacological Society Joint Symposium
The Japanese Society of Clinical Pharmacology and Therapeutics
JS(JSCPT-JPS)-1-1
Peramivir: A novel neuraminidase (NA) inhibitor against influenza virus with
a promising inhibitory activity of in vitro NA activity and in
vivo viral replication
Ryu Yoshida............ 12P
JS(JSCPT-JPS)-1-2
Pathogenesis of severe influenza and its prevention and treatments
Hiroshi Kido............ 12P
JS(JSCPT-JPS)-1-3
Structure-guided approach for the development of molecular-targeting agents
for AIDS therapy
Hiroaki Mitsuya............ 12P
The Japanese Society of Toxicology
JS(JST-JPS)-1-1
Integrated safety pharmacological evaluation using monkeys
Kentaro Ando............ 13P
JS(JST-JPS)-1-2
Pathologically modified in vivo animal models for safety pharmacology
Atsushi Sugiyama............ 13P
JS(JST-JPS)-1-3
On-chip pre-clinical cardiac toxicity: Testing compounds beyond hERG and QT
using hES/hiPS cardiomyocyte cell network re-entry model on a chip
Kenji Yasuda............. 13P
Symposia
S1A-1
Dysfunction of the central and/or autonomic nervous system induced by fatigue
and stress: a future prospect for therapeutic drugs
Nobuyuki Yanagihara and Yasuyoshi Watanabe............ 16P
S1G-2
Cognitive safety - a new framework for the safety of drugs
Kohji Takada and Shigeru Watanabe............ 17P
S1H-3
Therapeutic application based on new molecular mechanisms for cardiovascular
disease
Takahiro Iwamoto and Hiromu Kawasaki............ 17P
S1I-4
New therapeutic approach by combination of chronopharmacology and chrononeutrition
Shigenobu Shibata and Shigehiro Ohdo............ 18P
S1G-5
Research and development strategy of agents for Alzheimer's disease
Nobuya Matsuoka and Shin Araki........... 19P
S1H-6
Nutrigenomics and pharmacogenomics of obesity
Toshio Tanaka and Gozoh Tsujimoto............ 20P
S1I-7
New perspectives in NO/ROS signaling system
Akio Matsumoto and Takashi Uehara............ 21P
S1G-8
New developments in signaling-molecule transporters
Yoshikatsu Kanai and Yoshinori Moriyama............ 22P
S1H-9
Recent achievements available for the treatment of hyperuricemia and gout
Naohiko Anzai and Makoto Hosoyamada............ 23P
S1I-10
MicroRNAs in various disorders: their significances as pharmacological targets
Yoshihiko Chiba and Takao Hijikata............ 24P
S1G-11
Contributions of the central nervous systems in the modulation and pathogenesis
of peripheral disorders: a new strategy for targeting the central nervous systems
Masahiro Ohsawa and Yukio Ago............ 25P
S1H-12
Pathophysiological response to hypoxia -from the molecular mechanisms of malady
to drug discovery-
Toshiaki Tamaki and Masaomi Nangaku............ 26P
S1I-13
Various liver diseases: novel findings for the development of drug therapy
Nakajima Atsushi and Koichiro Wada............ 27P
S2A-14
Molecular mechanisms of stem cell differentiation and proposal of a prospective
pharmacological research for regenerative medication
Yukio Yoneda and Minoru Narita............ 28P
S2G-15
Research and development strategy of agents for cardiovascular disease
Akira Saito and Toshiro Shibano............ 29P
S2H-16
Neuroprotective and ameliorative actions of poly-unsaturated fatty acids against
neuronal diseases: evidence from basic to clinical studies
Tomohito Hamazaki and Michio Hashimoto............ 30P
S2I-17
A front line of the research for finding seeds against intractable pains
Kazuhide Inoue and Hiroshi Ueda............ 31P
S2G-18
Research and development strategy of agents for cancer
Takahito Hara and Yasuhiro Funahashi............ 32P
S2H-19
Potential utility of the micro-mini pig as a novel animal model
Atsushi Sugiyama and Yasukatsu Izumi............ 33P
S2I-20
Molecular mechanisms of central feeding regulation
Hiroshi Higuchi and Toshihiko Yada............ 34P
S2G-21
Pharmacology in Health Foods
Yasuo Matsumura and Masanori Yosizumi............ 35P
S2H-22
Novel Basic and Therapeutic Insights in Angiogenesis and Lymphangiogenesis
Masataka Majima and Peter Carmeliet............ 36P
S2I-23
Kampo pharmacology: basics of evidences-based herbal medicine
Hiroyasu Satoh and Kyoko Takahashi............ 37P
S2G-24
New wind of sensory pharmacology: oral sensory reflex as a target of new medicines
and functional foods
Minoru Wakamori and Hisayuki Uneyama............ 38P
S2I-25
Kampo (Japanese herbal medicine) therapy and its application for elucidation
of the CNS diseases
Shuichi Koizumi and Chihiro Tohda............ 39P
S3A-26
Signaling and development to cardiovascular diseases
Hitoshi Kurose and Kohji Fukunaga............ 40P
S3G-27
Research and development strategy of agents for metabolic disorders
Takanori Matsuo and Hideo Yukioka............ 41P
S3H-28
Ion dynamics in intracellular organelle as a new target of drug development
and its involvement in diseases
Hiroshi Hibino and Shigeki Kiyonaka............ 42P
S3I-29
Pharmacology for pharmaceutical care
Yuji Yoshiyama and Kumiko Kasashi............ 43P
S3G-30
Research and development strategy of agents for psychiatric disorders
Shigeyuki Chaki and Takahiko Yano............ 44P
S3H-31
New optical technology toward next-generation drug screening
Yuji Ikegaya and Masamichi Ohkura............ 45P
S3I-32
Understanding of the pathology of disease associated with genomic or epigenetic
abnormalities and proposal of a new stratagem for pharmacotherapy
Tsutomu Suzuki and Hiroshi Takeda............ 46P
S3G-33
Novel situations of endothelial injury on stroke: novel mechanisms on stroke
and strategy of drug developments
Kazuo Umemura and Koichiro Wada............ 47P
S3G-34
Novel perspective on bone metabolism and promising therapeutics against bone
resorptive disorders
Hitoshi Amano and Masaru Ishii............ 48P
S3I-35
Current progress of ocularpharmacology
Hideaki Hara and Makoto Aihara............ 49P
Award Candidate Sessins ......... 51P
Free Communications
Oral Sessions ......... 81P
Poster Sessions .......... 129P
Author Index ............. 1
Subject Index ............. 33
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