The 78th Annual Meeting of
The Japanese Pharmacological Society
March 22-24, 2005
Yokohama
Chairman: Masao Endoh
Abstracts
Secretariat
Department of Cardiovascular Pharmacology,
Yamagata University School of Medicine
Plenary Lectures
PL-1
Regulatory mechanisms of synaptic transmission in the neural circuit
Shigetada Nakanishi .......... 2P
PL-2
Arterial aging in apparent health promotes arterial diseases
Edward G. Lakatta .......... 2P
PL-3
Ghrelin: Discovery and physiological significance
Kenji Kangawa .......... 3P
PL-4
Cardiac adrenoceptors: physiological and pathophysiological relevance
Otto-Erich Brodde.......... 3P
Invited Lectures
IL-1
Glia-neuron networks: A new target for neuropharmacology
Yoshihisa Kudo.......... 6P
IL-2
Cellular and molecular responses to cerebral hypoxia: Involvement of ER in neuronal
death
Yasuyuki Nomura .......... 6P
IL-3
Pharmacology by a gleaner: Pharmacotherapeutics for the diseases due to tissue-generated
angiotensin II
Mizuo Miyazaki .......... 7P
IL-4
Targets to correct contractility defects in heart failure
Steven R. Houser .......... 7P
IL-5
Cellular mechanisms of immuno-modulation by Ganoderma lucidum polysaccharides
Zhi-Bin Lin .......... 8P
IL-6
Multiple roles of mitochondrion during experimental endotoxemia
Samuel H. H. Chan .......... 8P
IL-7
Prediction of drug metabolism parameters in humans: in vitro and in silico insights
John Oliver Miners ......... .9P
IL-8
Cardiac myocyte Ca2+ and Na+ regulation in normal and
failing hearts
Donald M. Bers.......... 9P
Educational Lectures
EL-1
Neuropharmacology of light, gas and gene
Naomasa Miki.......... 12P
EL-2
Progress in chloride pharmacology in brain
Chiyoko Inagaki......... 12P
EL-3
Regulations of the peripheral vascular tone by newly emerging Ca2+
entry channels and endothelial cells
Yushi Ito.......... 13P
Keynote Lecture
KL-1
New approach to cardiac tissue engineering
Thomas Eschenhagen.......... 16P
KL-2
Role of NCX, SR Ca2+ ATPase and SR Ca2+ leak in reducing
SR Ca2+ load in heart failire
Donald M. Bers.......... 16P
Award Lecture
AL
Molecular mechanism of vascular dysfunction in the insulin-resistant state
Kazuya Shinozaki......... 18P
Symposia
S01
The role of pharmacology in translational research
Yojiro Ukai and Kazuhiko Yanai.......... 20P
S02
Significance and risk assessment of QT interval prolongation in drug development
Yoshihisa Kurachi and Hiroshi Suzuki .......... 21P
S03
Transporters: Molecular targets and factors governing pharmacokinetics and pharmacodynamics
Yoshikatsu Kanai and Yuichi Sugiyama.......... 22P
S04
Current topics in the pharmacological research on bone metabolism
Hisashi Shinoda and Ken-Ichi Furukawa.......... 24P
S05
Molecular basis for lethal arrhythmias and pharmacological strategies for prevention
Haruaki Nakaya and Keitaro Hashimoto......... 25P
S06
Recent advances in and perspectives on tissue engineering
Hiroshi Iwao and Thomas Eschenhagen.......... 26P
S07
Smooth muscle research update: Differentiation, cell function, programmed cell
death and diseases
Hideo Kanaide and Yuji Imaizumi .......... 27P
S08
New development of chemogenomics and genomic drug discovery science
Gozoh Tsujimoto and Toshio Tanaka .......... 28P
S09
New approach for development of anti-Alzheimer's drugs
Yasushi Ohizumi and Hachiro Sugimoto....... 29P
S10
Pathophysiological significance of T-type calcium channels
Kyoichi Ono and Hikaru Tanaka.......... 31P
S11
Establishment of human tissue/organ resources utilized research system for pharmacological
therapeutics
Shinichi Kobayashi and Kyoichi Ohashi .......... 32P
S12
Unravelling cell signaling mechanism using new imaging techniques
Masamitsu Iino and Naoaki Saito.......... 33P
S13
Japanese pharmaceutical products of worldwide reputation and future of drug
development
Ryuichi Kato and Taku Nagao.......... 34P
S14
Recent advances in understanding of allergy
Yasushi Kuraishi and Naoki Inagaki.......... 36P
S15
Toward ion channel drug discovery: Potential approach and new technology
Shuji Kaneko and Yasuo Mori .......... 37P
S16
New topics on PACAP and its related peptides
Seiji Shioda and Akemichi Baba.......... 38P
S17
Angiogenesis and lymph angiogenesis as therapeutic targets for pathological
conditions
Masataka Majima and Hajime Kubo.......... 40P
S18
Recent progress in eicosanoid research
Fumitaka Ushikubi and Takehiko Yokomizo .......... 41P
S19
Pharmacological perspective for harmonization of Oriental and Western medicines
Takeshi Miyata and Toshihiko Iijima.......... 42P
S20
Up-to-date topics on heart failure - from molecular to clinical pharmacology
-
Shokei Mitsuyama and Hidenori Ichijo.......... 44P
S21
Application of pharmacogenomics to individualized therapy and drug development
Takashi Ishizaki and Taku Nagao.......... 45P
S22
Serotonergic mechanisms in stress and anxiety
Mitsuhiro Yoshioka and Norio Sakai.......... 46P
S23
Regulation of signaling and its-related disease in the CNS
Yasuyuki Nomura and Toshitaka Nabeshima..........47P
S24
Recent advances of molecular pharmacology on histamine system
Kazutaka Maeyama and Kazuhiko Yanai..........49P
S25
Progress in study of central feeding regulation by NPY
Hiroshi Higuchi and Masamitsu Nakazato.........50P
S26
New development of receptor pharmacology
Ikunobu Muramatsu and Shizuo Yamada..........51P
S27
From NMDA receptors to higher brain functions and dysfunction treatments
Masayoshi Mishina and Norio Matsuki..........52P
S28
Molecular mechanisms and therapeutic strategies of renal injury
Yoichi Abe and Katsuyuki Miura..........54P
S29
Topics in Na+/Ca2+ exchanger
Junko Kimura and Takahiro Iwamoto..........55P
Mini Symposia
MS-1
Characteristics of whole animal behavioral study
Norio Matsuki and Mitsuhiko Yoshioka..........60P
MS-2
Molecular and cellular responses of cardiovascular system induced by mechanical
and oxidative stresses
Koichi Nakayama and Satoshi Takeo..........62P
Free Communications
Oral Sessions ..........66P
Poster Sessions ..........140P
Author Index
Subject Index
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