March 8-10, 2004
Osaka
Chairman: Naomasa Miki
Abstracts
Secretariat
Department of Pharmacology
Osaka University Medical School
Plenary Lectures
PL-1
Interleukin 6; From Laboratory to Clinic
Tadamitsu Kishimoto .......... 2P
PL-2
β-Arrestins: Master Regulators of Seven Membrane Spanning Receptors
Robert J. Lefkowitz .......... 2P
PL-3
Pathophysiology of Chloride Transport: Lessons from Mouse Models and Human
disease
Thomas J. Jentsch .......... 3P
PL-4
Neuroinformatics: A new path to drug development
Floyd E. Bloom.......... 3P
PL-5
Gene Hunting in Cardiovascular Diseases
Pierre Corvol.......... 4P
Invited Lectures
IL-1
Studies on molecular mechanisms for pain and its control
Masamichi Satoh.......... 6P
IL-2
TRANSPORTERS AND NEW DRUG DEVELOPMENT
Hitoshi Endou .......... 6P
Educational Lectures
EL-1
Structure Analysis and Molecular Interaction of Proteins for Rational
Drug Design
Yuji Kobayashi.......... 8P
EL-2
On the advances of gastric studies over the past 40 years
Susumu Okabe.......... 8P
EL-3
Molecular mechanisms and therapeutic strategies for prion diseases
Shigeru Katamine.......... 8P
Award Lectures
AL-1
Molecular and pharmacological basis for the gating regulation of voltage-dependent
L-type Ca2+ channels
Satomi Adachi-Akahane......... 10P
AL-2
Analysis of PKC and DGK functions using live imaging technique
Yasuhito Shirai.......... 10P
AL-3
An independent, non-neuronal cholinergic system in lymphocytes and its
roles in
regulation of immune function
Takeshi Fujii.......... 10P
Symposia
S01
Recent progress in signal transduction towards the discovery of therapeutic
agents
Hiroyuki Nakanishi and Takayoshi Kuno.......... 12P
S02
Drug-induced fatal arrhythmias
Keitarou Hashimoto and Yoshihisa Kurachi .......... 13P
S03
Protein tyrosine phosphatases : Biology and pathology
Masaharu Noda and Fumio Nakamura.......... 14P
S04
Genomic approach to the development of new drugs for the treatment of
psychiatric disorders
Nobuyuki Yanagihara and Shigeo Kitayama.......... 15P
S05
Development of novel tools and methods for pharmacological study
Takeshi Nakamura and Takeshi Suzuki......... 17P
S06
New perspectives for studies of emotional experience and expression: From
animals to humans
Hisao Nishijo and Kazuhiko Yanai .......... 18P
S07
Neuronal morphologies and functions
Kozo Kaibuchi and Naoaki Saito .......... 19P
S08
Neuronal insulin signalings and their functional roles
Hideyuki Yamamoto and Hiroki Yokoo .......... 20P
S09
The latest frontiers in the treatment of allergic inflammation - Basic
analysis and clinical research
Masaaki Akagi and Hiroyuki Fukui ....... 21P
S10
Nuclear receptors on diseases: Nuclear receptors as targets for drug development
Atsushi Nakajima and Koichiro Wada.......... 23P
S11
Malfunction of vascular control in life-style related diseases
Tomio Okamura and Hiromu Kawasaki .......... 24P
S12
Up to date - Studies on serotonin transporter
Norio Sakai and Akira Sano.......... 25P
S13
Neuronal genesis and death - Aspects from cell cycle regulation
Nobuyoshi Nishiyama and Takao Takahashi.......... 26P
S14
Recent advances in research on physiological roles of nicotinic acetylcholine
receptors
Hiroshi Ueda and Koichiro Kawashima.......... 27P
S15
Pharmacotherapy of osteoporosis
Kenji Onodera and Masao Koida .......... 29P
S16
Topics on the mechanism of ER stress involvement in the regulation of
brain cell death
Yasuyuki Nomura and Masaya Tohyama.......... 30P
S17
Pathology in cardiovascular-related organs and new approaches to develop
their
therapeutic medicines
Yasushi Ohizumi and Katsuo Koike.......... 31P
S18
Molecular mechanism of drug dependence: New horizon of drug development
Masamichi Satoh and Toshitaka Nabeshima .......... 33P
S19
Update on agents for rheumatoid arthritis
Akira Saitou and Tohru Koide.......... 34P
S20
New expansion of sensation pharmacology
Kazuhide Inoue and Makoto Tominaga .......... 36P
S21
Molecular mechanism of cardiac remodeling and heart failure: New target
molecule for therapy
Katsutoshi Goto and Hiroshi Iwao.......... 37P
S22
Novel functions of calmodulin-dependent signal transduction and drug development
Yasuharu Sasaki and Koji Fukunaga .......... 38P
S23
Channel/transporter and disease
Tsutomu Tanabe and Hitoshi Endou ..........39P
S24
Molecular pharmacology of emotion - Basis for improvement of QOL -
Mitsunobu Yoshii and Masafumi Minami..........40P
S25
Induction of neural differentiation and its application for the regeneration.
Eiichi Taira and Tohru Yamakuni .........42P
S26
New perspectives in the studies on endocannabinoids and cannabis
Tsuneyuki Yamamoto and Michihiro Fujiwara ..........43P
S27
Frontiers in drug transporter research
Yuichi Sugiyama and Zen-ichi Terashita ..........44P
S28
Further pharmacological objectives in renin-angiotensin system
Mizuo Miyazaki and Takayoshi Tsutamoto ..........45P
S29
Update of the therapeutic drugs for Alzheimer's disease
Takeshi Kato and Yasuo Nagai ..........46P
S30
Regulation of protein nitration and its function
Akinori Akaike and Yoshinori Kamisaki ..........48P
S31
Transcriptional regulation of neuronal genes and its effect on neural
functions
Hiroshi Higuchi and Yoshiyuki Horio ..........49P
S32
Creation and development of informatics for pharmacological science -
application of genome network to pharmacology
Gozoh Tsujimoto and Toshio Tanaka ..........50P
S33
Role and regulation of non-phagocyte NADPH oxidase - A potential target
for drug discovery
Chihiro Yabe and Hideki Sumimoto ..........51P
S34
Histamine-related discoveries
Hiroshi Ohtsu and Noriyasu Hirasawa ..........52P
S35
Signal transduction pathways controlling neural circuit formation and
neuronal
morphogenesis
Shuh Narumiya and Haruhiko Bito ..........53P
S36
Prostaglandins and brain diseases
Kanato Yamagata and Kiyoshi Matsumura ..........54P
S37
Molecular mechanisms and drug development in aquaporin water channel diseases
Kenichi Ishibashi and Yasuko Ishikawa ..........56P
S38
Functional proteins involved in regulation of intracellular Ca2+ for drug
development
Yukio Yoneda and Toshio Matsuda ..........58P
S39
Recent progress of molecular pathophysiology and regeneration of neurodegenerative
disorders
Satoru Kato and Yoshihisa Ito ..........59P
S40
Pathophysiological roles of lipoxygenases and leukotrienes
Tanihiro Yoshimoto and Masayoshi Abe .........60P
S41
Wound healing mechanisms: From basal understandings to regenerative medicine
and drug developments
Koji Nobe and Mitsuru Uchida ..........61P
S42
Physiology and pathophysiology of protease-activated receptors (PARs)
Masahiro Nishibori and Atsufumi Kawabata ..........63P
S43
Glutamate receptors and brain functions
Masayoshi Mishina and Kenji Sakimura ..........64P
S44
Heterogeneity of G protein-coupled receptor generated by posttranslational
mechanisms and its clinical meanings
Hitoshi Kurose and Hiroyasu Nakata ..........65P
S45
Drug-induced QT prolongation: Strategy and evaluation of nonclinical and
clinical
studies
Toshiyasu Honbo and Keiji Yamamoto ..........66P
S46
Resolution and application of mechanotransduction mechanisms as a target
for new drugs
Hisayuki Ohata and Koichi Nakayama ..........68P
S47
Protein folding and ER function for drug development
Hirofumi Kai and Kazutoshi Mori .........69P
S48
Development of alternative animal experiments in pharmacology
Yuji Yoshiyama and Takashi Sugiyama ..........71P
Free Communications
Oral Sessions ..........73P
Poster Sessions ..........121P
Author Index
Subject Index
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