Jpn. J. Pharmacol. 81 (2), 237-239 (1999)

Oral Administration of Soybean Lecithin Transphosphatidylated
Phosphatidylserine (SB-tPS) Reduces Ischemic Damage
in the Gerbil Hippocampus

Satoru Suzuki, Masayoshi Furushiro, Masatoshi Takahashi, Masashi Sakai* and Satoshi Kudo

Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186 - 8650, Japan
* To whom correspondence should be addressed.

Abstract: Mongolian gerbils orally administered with soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS, 240 mg/kg) for 5 days were subjected to cerebral ischemia by bilateral common carotid artery occlusion. The pyramidal cell damage of the hippocampal CA1 subfield was classified into 4 grades according to the proportion of damaged neurons on the tenth day after the ischemic treatment. The damage score of the SB-tPS group was statistically less than that of the control group. This suggests that the pre-administration of SB-tPS may relieve the delayed neuronal cell death caused by cerebral ischemia.

Keywords: Phosphatidylserine, Oral administration, Cerebral ischemia

Copyrightę The Japanese Pharmacological Society 1999

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