Jpn. J. Pharmacol. 80 (3), 271-274 (1999)

Effects of Phenylephrine and Prazosin on Axial Movement of the Rat Incisor and Arterial Blood Pressure

Nami Ohyama (1) and Shizuyo Yamaguchi (2,*)

Departments of (1) Dental Anesthesiology and (2) Pharmacology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan
(*) To whom correspondence should be addressed.

Abstract: We investigated the dose-response effects of phenylephrine and antagonistic effects of prazosin on axial movement of the rat incisor and arterial blood pressure. Phenylephrine caused a temporal extrusive tooth movement and an increase in blood pressure at all doses. With increasing phenylephrine doses, the maximum extrusive tooth movement and maximum increase in blood pressure were enhanced. The maximum extrusive tooth movement and increase in blood pressure induced by phenylephrine were markedly suppressed after pretreatment with prazosin. These results suggested that extrusive tooth movement is closely related to the rise in blood pressure due to stimulation of vascular alpha1-receptors.

Keywords: Phenylephrine, Prazosin, Tooth movement

Copyrightę The Japanese Pharmacological Society 1999

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