Akihiro Haruno, Atsushi Sugiyama (*) and Keitaro Hashimoto
Department of Pharmacology, Yamanashi Medical University, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan
(*) To whom correspondence should be addressed.
Abstract: The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined
using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.
Keywords: Bisaramil, Cardiovascular effect, Blood-perfused preparation