Jpn. J. Pharmacol. 80 (3), 263-266 (1999)

Pharmacological Evaluation of a New Laser Blood Flowmeter for Measuring Coronary Blood Flow, Assessed in the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation in Comparison
With an Electromagnetic Flowmeter

Atsushi Sugiyama, Shunji Takehana and Keitaro Hashimoto

Department of Pharmacology, Yamanashi Medical University, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan

Abstract: A new portable-type laser blood flowmeter was recently developed for measuring the blood
flow in vessels. The sensitivity and specificity of the laser flowmeter was assessed in comparison with the well-established electromagnetic flowmeter using a canine isolated, blood-perfused ventricular tissue preparation. The laser flowmeter can record the phasic pattern of the coronary blood flow like the electromagnetic flowmeter. The extent of the changes after intracoronary administration of ACh and angiotensin II as well as coronary occlusion was almost identical between these two methods. These results suggest that the new laser flowmeter may possess potential utilities in both basic experimental and clinical practices.

Keywords: Portable-type laser blood flowmeter, Electromagnetic flowmeter, Phasic coronary blood flow

Copyrightę The Japanese Pharmacological Society 1999

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