Jpn. J. Pharmacol. 79 (4), 505-508 (1999)

Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats

Kazuki Nakamura (1), Yu Yamaguchi (1), Satomi Kagota (1), Kazumasa Shinozuka (1) and Masaru Kunitomo (1,2)

(1) Department of Pharmacology, Faculty of Pharmaceutical Sciences, and (2) Interdisciplinary Research Institute for Biosciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya 663-8179, Japan

Abstract: We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.

Keywords: Water extract of Cordyceps sinensis (WECS), Kupffer cell function, Colloidal carbon

Copyrightę The Japanese Pharmacological Society 1999

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