Jpn. J. Pharmacol. 79 (4), 501-504 (1999)

IPD-1151T (Suplatast Tosilate) Inhibits Interleukin (IL)-13 Release but Not IL-4 Release From Basophils

Michitaka Shichijo (1), Yasuo Shimizu (2), Kenju Hiramatsu (2), Michinori Togawa (1), Naoki Inagaki (1), Kenzo Takagi (2) and Hiroichi Nagai (1,*)

(1) Department of Pharmacology, Gifu Pharmaceutical University, Gifu 502-8585, Japan
(2) Department of Second Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8560, Japan
(*) To whom correspondence should be addressed.

Abstract: The effect of suplatast tosilate (IPD-1151T), which is known to suppress interleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited the antigen-induced release of IL-13 but not IL-4. These results suggest that IPD-1151T possesses different activity for the regulation of cytokine release in basophils and T cells.

Keywords: IPD-1151T (suplatast tosilate), Basophil, Interleukin-13

Copyrightę The Japanese Pharmacological Society 1999

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