Jpn. J. Pharmacol. 79 (4), 489-492 (1999)

Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187-Induced Histamine Release From Rat Peritoneal Exudate Cells

Masako Okazaki, Mayumi Tsuji, Yukako Yamazaki, Yuko Kanda, Shinichi Iwai and Katsuji Oguchi

Department of Pharmacology, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract: The effects of Sasa senanensis Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca2+]i) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca2+]i

level elevation.

Keywords: Degranulation, Bamboo grass leaf extract, Cytoplasmic free calcium

Copyrightę The Japanese Pharmacological Society 1999

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