Toshio Nakaki and Tomoko Fujii
Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173-8605, Japan
Abstract: Several lines of evidence have been accumulated for occurrence of nitration in vivo. In this brief review, we summarized nitration studies on functional changes of proteins, hormones and neurotransmitters, before as well as after the discovery of peroxynitrite. Most of nitrated molecules exhibit less active properties than the parental compounds. It is still unknown whether nitration is merely a footprint of oxidative stress, an important pathway of nitric oxide metabolisms or a part of integral processes for maintaining cellular homeostasis.
Keywords: Nitration, Nitric oxide, Peroxynitrite, Tetranitromethane, Hormone, Neurotransmitter, Tyrosine