Jpn. J. Pharmacol. 79 (1), 41-49 (1999)

Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach

Keiko Takemura (1), Kohei Takada (1,2), Shunichi Mameya (1), Muneshige Kaibara (1) and Kohtaro Taniyama (1,*)

(1) Department of Pharmacology, Nagasaki University School of Medicine, Nagasaki 852-8523 Japan
(2) Department of Surgery II, Kansai Medical University, Moriguchi 570-8506, Japan
(*) To whom correspondence should be addressed.

Abstract: Functions and the presence of 5-hydroxytryptamine (5-HT) receptors in the fundus, corpus and antrum of the guinea pig stomach were examined by measuring contractile force and acetylcholine (ACh) release. Stimulation of the 5-HT1 receptor caused tetrodotoxin (TTX)-insensitive relaxations in the preparations from 3 regions. Stimulation of the 5-HT2 receptor caused TTX-insensitive contractions in the preparations of fundus and antrum. Stimulation of 5-HT3 receptors caused contractions that were sensitive to TTX and atropine and enhanced the outflow of [3H]ACh from preparations of only antrum. Stimulation of 5-HT4 receptors caused contractions of antral strips and decreased relaxations of corporal strips and enhanced the outflow of [3H]ACh from the preparations of both corpus and antrum. In the guinea pig stomach, the fundus possesses relaxant 5-HT1 receptor < contractile 5-HT2 receptors and caused the contractile response to 5-HT. The corpus possesses relaxant 5-HT1 receptors and relaxant receptors other than 5-HT1, 5-HT2, 5-HT3 and 5-HT4 receptors > contractile 5-HT4 receptor, and therefore 5-HT caused relaxations. The antrum possesses relaxant 5-HT1 receptor < contractile 5-HT2, 5-HT3 and 5-HT4 receptors, and thus 5-HT caused contractions.

Keywords: Stomach fundus, Stomach corpus, Stomach antrum, Acetylcholine release, Contractile response

Copyrightę The Japanese Pharmacological Society 1999

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