Jpn. J. Pharmacol. 78 (3), 391-394 (1998)

In Vitro Effects of Calcium Dobesilate on the Responsiveness of Spontaneously Diabetic Rat Aorta

Mercedes Sanz, Emilio Ruiz, Patricia Ganado and Teresa Tejerina (*)

Department of Pharmacology, School of Medicine, Complutense University, 28040 Madrid, Spain
(*) To whom correspondence should be addressed.

Abstract: We tested the effect of calcium dobesilate (DOBE) in aorta from spontaneously diabetic (BB/wor) rats. The contraction induced by 10-6 M noradrenaline (NA) in BB/wor rats was smaller than that induced in control rats (1.21+/-0.11 vs 0.82+/-0.02 g, P<0.01, n=8, respectively) in arteries with intact endothelium. Incubation with DOBE (10-4 M) impaired the contractions induced by NA in BB/wor rats (1.21+/-0.11 vs 0.67+/-0.01 g, P<0.01, n=8). The effect of DOBE was reversed by 10-6 M propranolol (0.67+0.01 vs 1.20+/-0.60 g, P<0.001, n=8, with 10-4 M DOBE and 10-4 M DOBE plus 10-6 M propranolol, respectively). DOBE increased the endothelium-dependent relaxation in arteries from diabetic rats. These findings suggest that DOBE might improve vascular reactivity in BB/wor rats.

Keywords: Spontaneously diabetic rat, Aorta, Calcium dobesilate

Copyrightę The Japanese Pharmacological Society 1998

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