Jpn. J. Pharmacol. 78 (2), 241-243 (1998)

Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats

Masako Uchii, Miyuki Takashima, Tomomi Sugiyama and Nobuo Kosaka

General Pharmacology, Drug Discovery Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan

Abstract: The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.

Keywords: KW-8232, Bone loss, Sciatic neurectomy

Copyrightę The Japanese Pharmacological Society 1998

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