Jpn. J. Pharmacol. 78 (2), 233-235 (1998)

Induction of Fas Ligand and Fas Antigen mRNA Expressions in Interferon-gamma Transgenic Mouse Liver

Toshihiro Okamoto (1), Tomio Yamakawa (1), Ken-Ichi Yamamura (2) and Okio Hino (3)

(1) Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan
(2) Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 862-0976, Japan
(3) Department of Experimental Pathology, Cancer Institute, Tokyo 170-8455, Japan

Abstract: The interferon-gamma (IFN-gamma) transgenic mouse develops chronic hepatitis. In the present study, lymphoid cell infiltration and expression of the Fas system were studied in the transgenic mouse liver. Morphological analysis showed the infiltration of Iymphoid cells at the portal area and necro-inflammation in the lobules. Furthermore, the infiltrating Iymphoid cells were found to be present in the areas of piecemeal necrosis and the intralobular region. The polymerase chain reaction revealed induction of Fas antigen and Fas ligand mRNA expressions. The chronic hepatitis in this mouse reflects the profiles of human chronic hepatitis.

Keywords: Transgenic mouse, Fas, Liver

Copyrightę The Japanese Pharmacological Society 1998

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