Jpn. J. Pharmacol. 77 (3), 257-259 (1998)

Induction of CPP32-Like Activity and Inhibition of Interleukin 1beta Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model

Toshihiro Okamoto (1), Tadashi Kobayashi (1), Naoki Tsuzuike (2) and Kaoru Hara (1)

(1) Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan
(2) Zeria Pharmaceutical Co., Ltd., Konan-Machi, Ohsato-gun, Saitama 360-0111, Japan

Abstract: The objective of the present study was to determine the effects of concanavalin A (Con A) administration on the interleukin 1beta converting enzyme (ICE) activity and CPP32-like activity in mouse liver. Treatment with Con A (0.2 mg/mouse, i.v.) caused an elevated plasma alanine aminotransferase (ALT) level at 8 hr after Con A injection. ICE activity was decreased at 8 and 24 hr after Con A treatment. In contrast, CPP32-like activity was increased at 24 hr after Con A injection. Since CPP32-like activity was induced after ALT had increased, the induction of CPP32-like activity may not be involved in Con A-induced hepatitis.

Keywords: Concanavalin A, Interleukin 1beta converting enzyme, CPP32

Copyrightę The Japanese Pharmacological Society 1998

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