Jpn. J. Pharmacol. 76 (4), 425-429 (1998)

Role of Nitric Oxide in the Convulsions Following the Coadministration of Enoxacin With Fenbufen in Mice

Tohru Masukawa (1), Kunio Nakanishi (1) and Reiko Natsuki (2)

(1) Department of Clinical Biochemistry, (2) Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University, Nagaotogecho 45-1, Hirakata, Osaka 573-0101, Japan

Abstract: Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-Nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine. Brain NO synthase activity was significantly raised at 30 min after enoxacin when combined with fenbufen. The increased NO synthase activity was found to be suppressed by the pretreatment of 7-nitroindazole. These findings suggest that endogenous NO may be involved as a proconvulsant substance in the development of enoxacin-induced convulsions in mice pretreated with fenbufen.

Keywords: Convulsion, Enoxacin, Nitric oxide synthase

Copyrightę The Japanese Pharmacological Society 1998

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