Akira Ogawa (1), Mizue Maeguchi (2), Yoko Uchida (1), Toshimasa Yoshioka
(1), Makoto Kawashima (2) and Takamura Muraki (1)
(1) Department of Pharmacology and (2) Department of Dermatology, Tokyo Women's Medical University, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162-8666, Japan
Abstract: The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 microM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 microM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.
Keywords: Tazarotene, Dermal fibroblast, Collagen