Jpn. J. Pharmacol. 76 (1), 97-99 (1998)


Induction of Tumor Necrosis Factor-alpha mRNA in the Kidney of the Mouse Chronic Hepatitis Model

Toshihiro Okamoto (1), Masami Furuya (1), Tomio Yamakawa (1), Ken-ichi Yamamura (2) and Okio Hino (3,*)



(1) Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341, Japan
(2) Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto 862, Japan
(3) Department of Experimental Pathology, Cancer Institute, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170, Japan
(*) To whom correspondence should be addressed.

Abstract: Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.


Keywords: Transgenic mouse, Interferon, Tumor necrosis factor


Copyrightę The Japanese Pharmacological Society 1998

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