Masayoshi Furushiro, Satoru Suzuki, Yoshiyuki Shishido, Masashi Sakai,
Hideyuki Yamatoya,Satoshi Kudo, Shusuke Hashimoto and Teruo Yokokura
Yakult Central Institute for Microbiological Research, 1796, Yaho, Kunitachi, Tokyo 186, Japan
Abstract: Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.
Keywords: Phosphatidylserine, Passive avoidance, Scopolamine