Jpn. J. Pharmacol. 75 (4), 447-450 (1997)


Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Masayoshi Furushiro, Satoru Suzuki, Yoshiyuki Shishido, Masashi Sakai, Hideyuki Yamatoya,Satoshi Kudo, Shusuke Hashimoto and Teruo Yokokura


Yakult Central Institute for Microbiological Research, 1796, Yaho, Kunitachi, Tokyo 186, Japan

Abstract: Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

Keywords: Phosphatidylserine, Passive avoidance, Scopolamine


Copyrightę The Japanese Pharmacological Society 1997

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